20,151 results match your criteria Nevus Araneus Spider Nevus
Curr Health Sci J 2015 Jul-Sep;41(3):274-280. Epub 2015 Mar 15.
Pathology dept., Clinical Emergency County Hospital of Craiova.
The purpose of this study was the clinical and histo-immunohistochemical analysis of two cases: a cutaneous pigmented facial malignant melanoma and a lumbar congenital nevus with malignant transformation. A series of clinical elements raised the suspicion of some malignant melanocytic lesions and the histopathological analysis through the paraffin embedding technique confirmed the clinical suspicion. The immunohistochemical analysis using the streptavidin-biotin-peroxydase method of the facial malignant melanoma showed: S100 protein intense and diffuse positive, Tyrosinase diffuse positive, HMB45 strong and focal positive, Cyclin D1 positive in approximately 40% and Ki-67 positive in almost 70% of the tumor cells. Read More
Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.
Objective: To describe a rare case of Blue Rubber Bleb Nevus (BRBNS) with growth retardation and pubertal delay.
Clinical Presentation And Intervention: A 16-year-old boy with severe iron deficiency anemia was diagnosed with BRBNS, showing growth retardation and pubertal delay simultaneously. The patient was treated conservatively with intravenous iron therapy and his puberty advanced gradually. Read More
Ophthalmology 2018 Dec 8. Epub 2018 Dec 8.
Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical Center, New York, NY.
Purpose: GNAQ mutations have been identified in port wine stains (both syndromic and non-syndromic) and melanocytic ocular neoplasms. This study investigates the presence of GNAQ mutations in diffuse- (those associated with Sturge-Weber syndrome (SWS)) and solitary choroidal hemangiomas.
Participants: Tissue from 11 patients with the following diagnoses: port wine stain (n = 3), diffuse choroidal hemangioma (n = 1), solitary choroidal hemangioma (n = 6), choroidal nevus (n =1) METHODS: Ten specimens were interrogated with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT), a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 468 key cancer genes in formalin-fixed, paraffin-embedded tumors. Read More
Clin Ophthalmol 2018 15;12:2337-2345. Epub 2018 Nov 15.
Newcastle Eye Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK,
Background: An increasingly elderly population with a corresponding increase in ophthalmic conditions has led to increased pressure on hospital eye services (HES). In this study, we evaluated the use of a medical retina virtual clinic (MRVC), which has expanded into assessing all new medical retina referrals, where the need for urgent treatment was not clear.
Methods: Retrospective analysis of all new patients who were seen in the MRVC between April 2016 and May 2018. Read More
J Am Acad Dermatol 2018 Dec 6. Epub 2018 Dec 6.
Chief and profesor for dermatology department; Place where work was done: Universidad Autonoma de Nuevo León, Facultad de Medicina, Hospital Universitario ''Dr. José E. González'' Servicio de Dermatología, Monterrey, NL, México. Electronic address:
J Invest Dermatol 2018 Dec 6. Epub 2018 Dec 6.
Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.
Early diagnosis improves melanoma survival, yet the histopathological diagnosis of cutaneous primary melanoma can be challenging even for expert dermatopathologists. Analysis of epigenetic alterations, such as DNA methylation, that occur in melanoma can aid in its early diagnosis. Using a genome-wide methylation screen, we assessed CpG methylation in a diverse set of 89 primary invasive melanomas, 73 nevi, and 41 melanocytic proliferations of uncertain malignant potential, classified based on interobserver review by dermatopathologists. Read More
J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.
Dermatology Clinic - Department of Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.
Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known.
Objective: Prospective study on clinical and dermatoscopic effects of photoepilation on melanocytic nevi.
Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up program from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Read More
Br J Dermatol 2018 Dec 5. Epub 2018 Dec 5.
Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands.
Basal cell naevus syndrome (BCNS) is associated with germline mutations in the PTCH1 gene. Postzygotic mosaicism can also cause BCNS. Here we describe two patients, one with multiple basal cell carcinomas (BCCs) and one with clinical BCNS, who had no PTCH1 mutation in DNA extracted from blood. Read More
Br J Dermatol 2018 Dec;179(6):1432-1433
Department of Dermatovenereology, West China Hospital, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
J Cutan Pathol 2018 Dec 2. Epub 2018 Dec 2.
Geisel School of Medicine at Dartmouth, Hanover, NH.
Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hybridization were used to arrive at the correct diagnosis. Read More
Clin Exp Dermatol 2018 Dec 1. Epub 2018 Dec 1.
Dermatology Department, Brighton and Sussex University Hospitals NHS Trust, Brighton General Hospital, Elm Grove, Brighton, East Sussex, BN2 3EW, UK.
Oman J Ophthalmol 2018 Sep-Dec;11(3):265-266
Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Giant Congenital Melanocytic Nevus (GCMNs) is mostly reported in area of trunk followed by limbs and head. Their incidence is <1:20,000 newborns It derives attention due to its association with malignant melanoma.The risk of developing malignant melanoma is between 5 to 10%. Read More
Clin Pediatr (Phila) 2018 Dec 3:9922818816421. Epub 2018 Dec 3.
1 University of Miami, Miami, FL, USA.
Background: Prior reports on large congenital melanocytic nevi (LCMN) do not provide a clear management approach to physicians to advise parents or patients. Whether the presence of a halo around the nevus can guide management has not been fully explored.
Design: Children born with an LCMN were observed without active intervention. Read More
Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1360-1365
Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China.
Objective: To investigate the expression profile of miR-122-5p in melanoma tissues and the effect of miR-122-5p on the proliferation, cell cycle and apoptosis of human melanoma cell lines SK-MEL-110 and A375.
Methods: The expression profiles of miR-122-5p in melanoma and pigmented nevus tissues were detected using real-time fluorescence quantitative PCR (qRT-PCR). SK-MEL-110 and A375 cells transfected with miR-122-5p inhibitor or negative control inhibitor (NC) I were examined for miR-122- 5p expression using qRT-PCR and changes in cell proliferation, cell cycle and apoptosis using MTT assay or flow cytometry. Read More
JAAD Case Rep 2018 Nov 14;4(10):1080-1082. Epub 2018 Nov 14.
Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
J Cell Physiol 2018 Nov 30. Epub 2018 Nov 30.
Department of Musculoskeletal Cancer Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China.
The melanoma is one of the most dangerous forms of skin diseases. It may spread to other parts of the body and cause serious illness and death. Early detection and diagnosis are crucial. Read More
Cutis 2018 Oct;102(4):291-294
Nova Southeastern University College of Osteopathic Medicine/Largo Medical Center, Florida, USA.
Nevus sebaceus (NS)(organoid nevus) is a benign follicular neoplasm that commonly occurs on the scalp, face, or neck. With time, it may give rise to benign or malignant tumors such as trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma (BCC). Rarely, other types of neoplasms may develop. Read More
J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.
Department of Laboratory Medicine, Tongji hospital of Tongji University, Shanghai, China.
Objective: To investigate the effect of microRNA-137 (miR-137) on the migration and invasion of melanoma cells and its mechanism.
Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-137 in melanoma tissues and cells. miR-137 mimics, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) small interfering RNA and corresponding controls were transfected into A375 and WM451 cells by lipofection. Read More
An Bras Dermatol 2018 Nov/Dec;93(6):905-906
Dermatology Service, Hospital do Servidor Público do Estado de São Paulo, São Paulo (SP), Brazil.
We report a case of a 76-year-old patient with a history of recent weight loss and ulcerated umbilical nodular lesion. Initially, we considered the diagnostic hypothesis of Sister Mary Joseph's nodule. However, histopathological evaluation revealed that it was an ulcerated intradermal nevus. Read More
Telemed J E Health 2018 Nov 27. Epub 2018 Nov 27.
1 Wills Eye Hospital, Thomas Jefferson University , Philadelphia, Pennsylvania.
Purpose: To determine the incidence of diabetic retinopathy (DR) and other ocular findings in previously diagnosed diabetes using telehealth retinal screening with nonmydriatic fundus photography (nFP) in primary care physicians' offices.
Methods: A retrospective study based on electronic chart review was performed. All diabetic patients who participated in the Wills Eye Hospital (WEH) telehealth retinal screening program from July 1, 2012 to February 20, 2017 were included. Read More
Dermatol Pract Concept 2018 Oct 31;8(4):320-321. Epub 2018 Oct 31.
Department of Dermatology, Hospital Clínico San Carlos, Madrid, Spain.
Dermatol Pract Concept 2018 Oct 31;8(4):306-313. Epub 2018 Oct 31.
Anatomic Pathology Unit, Hospital of Macerata, Italy.
Background: In spite of recent advances in the histopathological and molecular diagnosis of melanocytic neoplasms, a certain proportion of these lesions remain a daunting challenge for both the clinician and the pathologist.
Objectives: To emphasize the importance of close collaboration between clinicians and pathologists in case of problematic melanocytic lesions.
Patients: We report and discuss 5 problematic scenarios of melanocytic lesions, including tumoral melanosis, nevoid melanoma, lentiginous melanoma, spitzoid melanoma and BAPoma that may pose diagnostic difficulties in our practice. Read More
J Ophthalmic Vis Res 2018 Oct-Dec;13(4):501-503
Liverpool Ocular Oncology Centre, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, England, UK.
Purpose: To report a case exhibiting drastic regression of a conjunctival nevus in a child.
Case Report: Spontaneous regression of conjunctival nevus is uncommon. We report the case of a nine-year-old Caucasian boy presenting a conjunctival-pigmented lesion situated at the plica semilunaris that underwent a significant reduction in size and color over a period of 15 months. Read More
Vet Dermatol 2018 Nov 25. Epub 2018 Nov 25.
Institute of Genetics, Vetsuisse Faculty, University of Bern, Länggassstrasse 120, 3001, Bern, Switzerland.
Background: The feline counterpart of human inflammatory linear verrucous epidermal nevus (ILVEN) has been described; however, the possible underlying developmental defect has not been investigated.
Objective: To report a case of multiple ILVEN-like lesions in a cat with a genetic variant in the NSDHL gene.
Animals: A 2-year-old, female, domestic short hair cat with a history of multiple alopecic, verrucous, hyperpigmented and erythematous skin lesions, following Blaschko's lines on the head, the limbs, the trunk and paw pads. Read More
J Curr Glaucoma Pract 2018 May-Aug;12(2):94-98. Epub 2018 Aug 1.
Senior Resident, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
Aim: To report a case of bilateral phacomatosis pigmentovascularis (PPV), in a young male,presenting with developmental glaucoma and high myopia along with systemic features of klippel trenanauy weber (KTW) syndrome.
Background: The co-existence of oculodermal melanocytosis (ODM)and port-wine stain was termed PPV by Ota. Port-wine stain presents as part of Sturge-Weber syndrome (SWS). Read More
Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.
Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Nevus comedonicus is a rare cutaneous follicular hamartoma, characterized by the clustering of papules with firm, blackened horny buffers. It is usually present at birth or during childhood, although few cases of late-onset disease have been described. We present a case of postmenopausal-onset nevus comedonicus in a 55-year-old white woman without relevant medical history. Read More
Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.
Deramatology, Hospital Universitario 12 de Octubre, Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain.
Neurocristic cutaneous hamartomas (NCHs) are rarely reported tumors with divergent differentiation derived from persistently active pluripotent cells from the neural crest. They result from aberrant development of the neuromesenchyme, and they can express fibrogenic, melanocytic, and/or neurosustentacular differentiation. Thus, congenital melanocytic nevus also represents a neurocristic dysplasia of the skin in which cells are melanogenic cells arrested in development located in the reticular dermis, and nodular proliferative neurocristic hamartoma may arise within a congenital melanocytic nevus. Read More
Clin Exp Dermatol 2018 Nov 20. Epub 2018 Nov 20.
Department of Dermatology, Dr RML Hospital, PGIMER, Baba Kharak Singh Marg, New Delhi, 110001, India.
Biosci Rep 2018 Nov 20. Epub 2018 Nov 20.
Xiangya Hospital, Central South University, Changsha, China
Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. NFAT1 has been shown to promote melanoma growth and metastasis in vivo. We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties. Read More
JAAD Case Rep 2018 Nov 9;4(10):1010-1013. Epub 2018 Nov 9.
Department of Dermatology, the University of California, Irvine, California.
Eplasty 2018 5;18:e30. Epub 2018 Oct 5.
Plastic and Reconstructive Surgery Section, Department of Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Facial giant congenital melanocytic nevus represents a major cosmetic deformity for the child and parents and is a challenge for the plastic surgeons to achieve best cosmetic results. Herein, we present a case of single-stage surgical reconstruction using partial-thickness scalp skin graft aided with Matriderm dermal substitute for a facial giant congenital melanocytic nevus. An 8-year-old boy presented with a facial giant congenital melanocytic nevus without leptomeningeal involvement. Read More
Australas J Dermatol 2018 Nov 18. Epub 2018 Nov 18.
Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Tottori University, Yonago, Japan.
Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.
Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.
Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More
J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):219-221
Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Congenital nevi and fibrolipomatous hamartoma are benign tumors of childhood, the latter being very uncommon. Fibrous hamartoma of infancy typically occurs in <2 years of life. The concurrence of these two lesions is extremely rare. Read More
Nat Commun 2018 11 14;9(1):4774. Epub 2018 Nov 14.
QIMR Berghofer Medical Research Institute, Brisbane, Australia.
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. Read More
PLoS One 2018 8;13(11):e0207019. Epub 2018 Nov 8.
Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Introduction: Finding new markers to assess prognosis of melanoma without the necessity to perform a surgical interventions is an important goal in melanoma research. The current study aimed to assess the correlation of clinical course and prognosis of primary and metastatic melanoma with expression of VEGF family and their receptors.
Methods: A ngTMA block was made from the randomly selected paraffin tissue blocks of the patients with melanocytic nevi, primary and metastatic melanoma. Read More
Eur J Dermatol 2018 Oct;28(5):704-705
Department of Dermatology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-8543, Japan.
JAAD Case Rep 2018 Nov 29;4(10):972-975. Epub 2018 Oct 29.
Department of Dermatology, University of Massachusetts Medical School, UMass Memorial Healthcare, Worcester, Massachusetts.
Case Rep Pediatr 2018 8;2018:7654278. Epub 2018 Oct 8.
Division of Pediatric Hematology/Oncology, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free. Read More
Am J Dermatopathol 2018 Oct 29. Epub 2018 Oct 29.
Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. Read More
Pediatr Dermatol 2018 Nov;35(6):854-855
Department of Dermatology, Oregon Health and Science University, Portland, Oregon.
Pediatr Dermatol 2018 Nov;35(6):821-822
J Craniofac Surg 2018 Nov 2. Epub 2018 Nov 2.
Division of Plastic Surgery, Children's National Health System, Washington, DC.
Schimmelpenning syndrome is a neurocutaneous disorder characterized by craniofacial nevus sebaceus that fall along embryonic cutaneous lines and tend to be associated with neurological, ocular, skeletal, and vascular abnormalities. We report a child with extensive nevus sebaceus of the scalp, face, and thorax and other unusual physical findings who was found to have a mosaic mutation of KRAS c.35G>A p. Read More
J Eur Acad Dermatol Venereol 2018 Nov 5. Epub 2018 Nov 5.
Division of Dermatology, Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Background: Cutaneous malignant melanoma metastases differential diagnosis is challenging, as clinical and dermoscopic features can simulate primary melanoma or other benign or malignant skin neoplasms, and in-vivo reflectance confocal microscopy could assist. Our aim was to identify specific reflectance confocal microscopy features for cutaneous malignant melanoma metastases, and epidermal and dermal involvement.
Methods: A retrospective, multicentre observational study of lesions with proven cutaneous malignant melanoma metastases diagnosis between January 2005 and December 2016. Read More
Int J Trichology 2018 Jul-Aug;10(4):186-188
Department of Dermatology, Venereology and Leprology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
Int J Trichology 2018 Jul-Aug;10(4):180-182
Department of Dermatology, Venereology and Leprosy, Seth G S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Woolly hair nevus is a rarely acquired disorder of the scalp hair with well-circumscribed patch of curly and unruly hairs which are smaller in diameter than normal surrounding hair. We report a case of progressively evolving multiple woolly hair nevi in a 10-year-old child. Trichoscopy of unruly hairs showed abnormal kinking of hair shafts. Read More
BMC Ophthalmol 2018 Oct 30;18(1):283. Epub 2018 Oct 30.
Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, 1 Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Background: Universal ocular screening of infants is not a standard procedure in children's health care system in China. This pilot study investigated prevalence of ocular abnormalities of 6 weeks-age infants using wide-field digital imaging system.
Methods: Infants aged 6 weeks around were consecutively enrolled in a public hospital between April 2015 and August 2016. Read More
Int J Dermatol 2019 Jan 29;58(1):e10-e12. Epub 2018 Oct 29.
Department of Surgical Sciences, Section of Pathology, University of Cagliari, Cagliari, Italy.
Pan Afr Med J 2018 14;30:132. Epub 2018 Jun 14.
Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.
Sebaceous naevus (sebaceous hamartoma) is a congenital lesion mainly localized to the scalp, whose clinical and histologic diagnosis is generally easy. In the vast majority of cases, it is diagnosed at birth, but it can sometimes go unnoticed and give the impression to occur later. This lesion may be complicated by benign tumors or more rare malignancies. Read More