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MedEdPORTAL 2016 Aug 5;12:10431. Epub 2016 Aug 5.

Assistant Professor of Dermatology and Internal Medicine, Harvard Medical School.

Introduction: This introductory skin cancer video module engages novice health care professionals to make histological-clinical correlations for the three most common skin cancers: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. The goal of this video module is to engage novice health care professionals (e.g. Read More

Dermatol Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmic Plastic Surgery, LV Prasad Eye Institute, Hyderabad, India.

Int J Trichology 2019 Mar-Apr;11(2):92-93

Department of Dermatology, Hospital Clínic, University of Barcelona, Spain.

Int J Dermatol 2019 Apr 21. Epub 2019 Apr 21.

Departments of Pediatrics, Laboratory Medicine, and Pathology, The University of Alberta, Edmonton, Alberta, Canada.

Melanonychia striata is characterized by a tan, brown, or black longitudinal streak within the nail plate that runs from the proximal nail fold to the distal part of the nail plate. Melanonychia striata is due to increased activity of melanocytes or melanocytic hyperplasia in the nail matrix with subsequently increased melanin deposition in the nail plate. The most common cause of melanonychia striata associated with melanocytic activation is ethnic melanonychia which occurs in dark-skinned individuals. Read More

Pigment Cell Melanoma Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah.

Germline mutations in CDKN2A (p16) are commonly found in patients with family history of melanoma or personal history of multiple primary melanomas. The p16 tumor suppressor gene regulates cell cycle progression and senescence through binding of cyclin-dependent kinases (CDK) and also regulates cellular oxidative stress independently of cell cycle control. We identified a germline missense (c. Read More

Cancers (Basel) 2019 Apr 16;11(4). Epub 2019 Apr 16.

Department of Dermatology, Venerology and Allergology, University Hospital Essen, 45147 Essen, Germany.

Acral naevi are benign melanocytic tumors occurring at acral sites. Occasionally they can progress to become malignant tumors (melanomas). The genetics of acral naevi have not been assessed in larger studies. Read More

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, P.R. China.

Melanoma is considered as an aggressive neoplastic transformation and featured with high metastatic potential. Although some studies have provided targets for novel therapeutic interventions, clinical development of targeted drugs for melanoma still remains obscure. Therefore, this study aims to identify the role of microRNA-27a (miR-27a) in autophagy and apoptosis of melanoma cells in regulating spleen tyrosine kinase (SYK)-mediated the mammalian target of rapamycin (mTOR) signaling pathway. Read More

J Glaucoma 2019 Apr 15. Epub 2019 Apr 15.

Division of Ophthalmology, Faculty of Medicine and Health Sciences, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa.

Background: Phacomatosis pigmentovascularis has previously almost exclusively been reported in Asians and in dermatological journals. In this report, we present a case of a young black South African male referred to our eye clinic.

Case Presentation: A 15-year-old male patient presented with gradual, painless loss of vision in his right eye. Read More

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, University Children's Hospital Niño Jesús, Madrid, Spain.

The"Bork-Baykal phenomenon" refers to the sparing of the nipple-areola complex in large congenital melanocytic nevi involving the breast. So far, this finding has not been reported in vascular anomalies. We present four patients with an extensive capillary malformation (CM) involving the breast that was found to exhibit a similar sparing of the nipple and areola. Read More

J Clin Aesthet Dermatol 2019 Mar 1;12(3):40-43. Epub 2019 Mar 1.

Drs. Paninson, Trope, and Ramos-e-Silva are with the Sector of Dermatology, Postgraduation Course in Dermatology at the University Hospital and School of Medicine, Federal University of Rio de Janeiro in Rio de Janeiro, Brazil.

The nevus sebaceous of Jadassohn, usually present at birth, is a hamartoma composed predominantly of sebaceous glands, which can progress to benign and malignant tumors. Malignant neoplasms on the nevus sebaceous occur in about 2.5 percent of cases, with basal cell carcinoma accounting for 1. Read More

Am J Surg Pathol 2019 May;43(5):581-590

Division of Anatomic Pathology, Mayo Clinic, Rochester, MN.

Angiosarcoma is a rare malignant neoplasm of the liver. The various morphologic patterns seen with angiosarcomas of the liver have not been systematically studied and their recognition remains a major diagnostic challenge. In order to provide more comprehensive data on the morphologic patterns, angiosarcomas that had been diagnosed between 1996 and 2016 at a large medical referral center were reviewed. Read More

Indian Dermatol Online J 2019 Mar-Apr;10(2):186-187

Department of Pediatrics, PGIMER, Chandigarh, India.

Indian J Plast Surg 2018 Sep-Dec;51(3):309-315

Plastic Surgery Division, Department of Surgery, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.

Background: With the rise in working-age population, there has been notable economic growth in Indonesia. Along with it, there is an increase in expenditure for non-food items such as health-care service, without exception to plastic surgery practice. Aesthetic plastic surgery practice has gained its popularity in several other developing countries such as Brazil, Russia, India and China. Read More

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Division of Pediatric Dermatology, University of Minnesota, Minneapolis, Minnesota.

We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Read More

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Department of Dermatology, Venereology and Leprosy, Dr. Ram Manohar Lohia Post Graduate Institute of Medical Education and Research, New Delhi.

Nevus comedonicus is an uncommon hamartoma of the pilosebaceous unit characterized by keratin filled pits simulating open comedones. It may present at birth but is more commonly seen during childhood or adolescence. The most commonly affected sites are the face, neck, trunk, and arms with a few reported cases on palms, genitalia, and scalp. Read More

JAAD Case Rep 2019 Apr 30;5(4):317-318. Epub 2019 Mar 30.

Metrohealth Medical Center and Case Western Reserve University, Cleveland, Ohio.

Ocul Oncol Pathol 2019 Feb 12;5(2):102-109. Epub 2018 Jul 12.

Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.

Purpose: To describe our early experience with gene expression profiling (GEP) assessment for juxtafoveal, subfoveal, and peripapillary indeterminate high-risk melanocytic lesions to assist in making early treatment decisions in patients who did not feel comfortable with either close observation or definitive treatment.

Methods: A prospective cohort of patients with indeterminate lesions who underwent GEP were enrolled. Nonparametric statistical analysis was utilized given the small sample size. Read More

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Italy.

Background: In-vivo reflectance confocal microscopy significantly improves melanoma diagnosis as compared to clinical/dermoscopic examination alone. Several confocal criteria have been described allowing to differentiate melanoma from nevi; by combining different criteria three pure confocal scores (Pellacani 2005, Segura 2009 and Pellacani 2012) and one mixed dermoscopic/confocal score (Borsari 2018) were constructed.

Objective: Our aim was to externally validate and compare the performance of these confocal scores. Read More

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

LABIOMEP, INEGI-LAETA, Faculdade de Engenharia, Universidade do Porto.

Background: The incidence rates of melanoma have risen to worrying levels over the last decade. Delayed diagnosis, due to faults on the detection stage, indicate the necessity of new aiding diagnosis techniques. Since metabolic activity is highly connected to neoplasia formation, a detection technique that focus its results on vascular responses, as IRT, seems to be a viable option. Read More

Ann Plast Surg 2019 May;82(5S Suppl 4):S306-S309

Division of Plastic and Reconstructive Surgery, Cedar-Sinai, Los Angeles, CA.

Background: Congenital melanocytic nevi (CMN) have a 1% to 5% lifetime risk for malignant transformation, with 50% of transformations occurring before the age of 5 years.The aim of this study is to assess the risk of melanoma development in pediatric patients with facial CMN involving the eyebrows, eyelid margins, and nasal alae where a margin of CMN was not excised to preserve these structures.

Methods: A retrospective chart review of all pediatric patients with CMN from 1986 to 2014 was performed to review demographic information, diagnosis, and number of surgeries. Read More

J Pathol Inform 2019 21;10. Epub 2019 Feb 21.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Accurate diagnosis of melanocytic lesions is challenging, even for expert pathologists. Nowadays, whole-slide imaging (WSI) is used for routine clinical pathology diagnosis in several laboratories. One of the limitations of WSI, as it is most often used, is the lack of a multiplanar focusing option. Read More

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):115-121

Department of Oral and Maxillofacial Surgery, Haldia Institute of Dental Sciences and Research, West Bengal University of Health Sciences, Haldia, West Bengal, India.

Gorlin-Goltz syndrome (GGS) also known as the nevoid basal cell carcinoma syndrome or the nevus-Bifid rib syndrome is an inherited autosomal dominant syndrome. It is caused by genetic alteration produced by a mutation in the "patched" tumor suppressor gene. This rare syndrome is characterized by basal cell carcinoma of skin, multiple odontogenic keratocyst and bifid ribs along with other features such as hypertelorism, sex organ abnormalities, palmar and/or plantar pits and calcification of falx cerebri. Read More

Hum Genome Var 2019 2;6:16. Epub 2019 Apr 2.

1Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry, Suita, Japan.

Basal cell nevus syndrome (BCNS) is a rare, multisystem, autosomal dominant disorder that is characterized by various phenotypes, including multiple basal cell carcinomas of the skin, odontogenic keratocysts of the jaws, and occasionally cleft lip and/or palate. In this report, we describe a 6-year-old Japanese girl with a novel heterozygous nonsense mutation in who exhibited rare craniofacial phenotypes, such as oligodontia and a short-tooth root. Read More

J Am Acad Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica-Dermatologia, Reggio Emilia, Italy.

Background: Reflectance confocal microscopy (RCM)-based skin cancer diagnosis requires proficiency.

Aims: To identify a shortlist of key RCM features of skin cancers and test their diagnostic utility.

Methods: We identified key RCM features through consensus among six experts using a modified-Delphi method. Read More

Am J Dermatopathol 2019 Mar 26. Epub 2019 Mar 26.

Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL.

Lichen sclerosus (LS) is a chronic inflammatory dermatosis that classically presents as sclerotic, atrophic plaques in the genital region. We present a case of acrochordon with histological features of LS, clinically mimicking intradermal nevus, in a 53-year-old man with no prior history of LS. Our case highlights an unusual morphologic variant of acrochordon and illustrates the role of chronic pressure and occlusion in the development of secondary features of LS. Read More

Pigment Cell Melanoma Res 2019 Apr 4. Epub 2019 Apr 4.

Department of Biopathology, Centre Léon Bérard, Lyon, France.

A girl, born with a posterior  lumbosacral giant congenital nevus, developed a central nodule that expanded over a period of 14 months into a 10-cm pedunculated mass. Histological analysis of the mass revealed melanoma of myxoid, small round-cell type with areas of  rhabdomyosarcomatous  transformation confirmed by immunohistochemistry. RNA sequencing identified an in-frame SASS6(e14)-RAF1(e8) fusion in both components and the nevus. Read More

Oncol Lett 2019 May 19;17(5):4176-4182. Epub 2018 Nov 19.

Department of Dermatology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.

Melanoma is one of the most immunogenic tumors among human neoplasms, with numerous clinical observations of partial or completely regressed tumors. It is an aggressive tumor, with the greatest reported number of somatic mutations, BRAF mutation being the most common one. BRAF mutation is also present in a higher percentage in benign nevi. Read More

Sci Rep 2019 Apr 3;9(1):5559. Epub 2019 Apr 3.

Department of Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Many pivotal biological cell processes are affected by gravity. The aim of our study was to evaluate biological and functional effects, differentiation potential and exo-metabolome profile of simulated microgravity (SMG) on human hepatic cell line (HepG2) and human biliary tree stem/progenitor cells (hBTSCs). Both hBTSCs and HepG2 were cultured in a weightless and protected environment SGM produced by the Rotary Cell Culture System (Synthecon) and control condition in normal gravity (NG). Read More

South Med J 2019 Apr;112(4):210-214

From the Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock.

With the increase in participation in endurance events in the general population, patient concern may arise as to whether endurance exercise is safe. Acute but not chronic increases in blood urea nitrogen, creatinine, and urine albumin occur in endurance exercise. Iron-deficiency anemia may be observed in female athletes. Read More

Australas J Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Background/objectives: High a naevus counts and atypical naevi are risk factors for cutaneous melanoma. However, many individuals with a high-risk naevus phenotype do not develop melanoma. In this study, we describe the clinical and dermoscopic attributes of naevi associated with melanoma in a high-risk naevus phenotype population. Read More

No Shinkei Geka 2019 Mar;47(3):349-356

Department of Neurosurgery, Brain Research Institute, Niigata University.

We present the case of an 11-month-old girl with linear nevus sebaceous syndrome who underwent posterior quadrantectomy(PQ)for intractable epilepsy due to cortical dysplasia extending from the temporal, parietal, and occipital lobes in the right hemisphere. Epileptic spasms started at 4 months after birth, and the frequency of her seizures gradually increased to 10 episodes per day. Electroencephalograms in the interictal periods showed hypsarrhythmia. Read More

Dermatol Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan.

Background: Treatment of nevus sebaceus (NS) on the scalp is usually surgical excision, but the optimal timing is debatable. The scalp presents significant challenges to the reconstructive surgeon because the lack of elasticity of the scalp makes the repair of defects difficult.

Objective: The aim of this study was to investigate the optimal timing for surgical excision of NS on the scalp through postoperative outcomes. Read More

Acta Derm Venereol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Hospital Clínic de Barcelona, IDIBAPS, ES-08036 Barcelona, Spain.

Patients treated with haematopoietic stem cell transplantation are at increased risk of cutaneous malignant neoplasms. There are no reports on the characteristics of melanocytic lesions in patients with chronic graft versus host disease and the value of recognizing these difficult lesions in high-risk patients. The objective of this study is to describe the clinical and dermoscopic characteristics of melanocytic lesions in patients with chronic graft versus host disease in order to understand their morphology. Read More

Aesthetic Plast Surg 2019 Apr 1. Epub 2019 Apr 1.

Department of Plastic and Reconstructive Surgery, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, South Korea.

Background: A congenital divided nevus, also known as kissing nevus, is a type of congenital compound nevus that affects equal areas of the upper and lower eyelids. The edges of the nevus touch or "kiss" during closure of the lids, owing to its extension to the lid margins. Multiple treatment modalities, such as dermabrasion, cryotherapy, primary closure after excision, and skin grafts, have been proposed; however, complications such as recurrence, ectropion, skin color mismatch, and scar contractures are known to occur. Read More

Cancers (Basel) 2019 Mar 29;11(4). Epub 2019 Mar 29.

Istituto Dermopatico dell'Immacolata (IDI-IRCCS), 00167 Rome, Italy.

Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e. Read More

J Am Acad Dermatol 2019 Mar 27. Epub 2019 Mar 27.

University of Connecticut Health Center Dermatology Department. Electronic address:

Pan Afr Med J 2018 24;31:50. Epub 2018 Sep 24.

CNAM (ex Institut Marchoux), Bamako, Mali.

Verrucous nevus is a benign tumor showing a linear pattern on Blaschko lines. It is caused by mosaic mutations of the receptor FGFR3 gene. It manifests as an aesthetic disfigurement, but individuals even experience functional complications due to itchiness. Read More

J Pediatr Psychol 2019 Mar 26. Epub 2019 Mar 26.

Department of Psychosomatics and Psychiatry, and Children's Research Center, University Children's Hospital.

Objectives: This cross-sectional study assessed health-related quality of life (HRQOL) and psychological adjustment in children and adolescents affected by congenital melanocytic nevi (CMN) and identified potential predictors of adjustment.

Methods: Participants were recruited worldwide with the help of patient organizations. Data were obtained from parents of 235 children affected by CMN, aged between 1 month and 18 years (M = 6. Read More

JAMA Dermatol 2019 Mar 27. Epub 2019 Mar 27.

Cutaneous Biology Research Institute, Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Eur J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Recurrent nevi occur following removal of melanocytic nevi mainly after shaving excision. Due to its differential diagnosis with melanoma, its recognition can be challenging. To evaluate clinical and dermoscopic predictors of recurrent nevi. Read More

World Neurosurg 2019 Mar 20. Epub 2019 Mar 20.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Division of Neurosurgery, Department of surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address:

Background: Primary melanocytic neoplasms (PMNs) are rare neoplasms, especially within the central nervous system. Meningeal melanocytomas, which belong to PMNs, are even rarer. Nevus of Ota results from the incomplete migration of melanocytes from the neural crest. Read More

J Invest Dermatol 2019 Apr;139(4):756-759

Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia. Electronic address:

Large-giant congenital melanocytic nevi have been well characterized clinically, yet questions remain about the heterogenous phenotypes observed. Martins da Silva et al. (2018) highlight the genotypic diversity between "classic" and "spilus-like" congenital melanocytic nevi by analyzing multiple biopsy sites and matching satellite nevi. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2019 03;28(1):41-43

National Institute of Dermatology (VMMC), Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Collagenomas are connective tissue nevi with hamartomatous proliferations of dominant dermal collagen. They can present as solitary or multiple inherited or acquired lesions over various body sites. The face is a rare site of collagenomas and, of the few cases reported in the literature, they have been seen more often on the scalp or on the plantar area. Read More

Cureus 2019 Jan 9;11(1):e3859. Epub 2019 Jan 9.

Oncology, Instituto Nacional De Cancerologia, Bogotá, COL.

Metastatic melanomas in the pediatric population are rare, but they have been appearing more frequently. Unfortunately, little is known about the differences in the biology and therapeutic implications of pediatric metastatic melanomas when compared to those found in adults. Herein, we have presented the case of a 13-year-old girl with a stage IIID malignant melanoma arising from a congenital nevus. Read More

Arch Med Sci 2019 Mar 28;15(2):434-448. Epub 2018 Mar 28.

Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, China.

Introduction: Spider nevus and subcutaneous collateral vessel of the chest/abdominal wall are common in liver cirrhosis. This prospective study aimed to evaluate the impact of spider nevus and subcutaneous collateral vessel of the chest/abdominal wall on the outcomes of cirrhotic patients.

Material And Methods: We prospectively enrolled patients with a diagnosis of liver cirrhosis consecutively admitted to our department. Read More

J Craniofac Surg 2019 Mar 16. Epub 2019 Mar 16.

Division of Plastic and Reconstructive Surgery, Keck School of Medicine, University of Southern California.

Congenital and pediatric nasal lesion resection and their reconstructive outcomes are not well studied. A surgeon must consider the site, size, depth, etiology, age, and effect on future function (including growth). As such, it is important to contrast the differences between the adult's and child's nose. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 Mar;50(3):183-186

A black teenager presented with long-standing vision loss in his right eye. Clinical exam revealed increased conjunctival vascularity and total exudative retinal detachment of the right eye. Ultrasound imaging demonstrated a choroidal mass with moderate-to-high reflectivity consistent with a choroidal hemangioma. Read More

Ophthalmic Plast Reconstr Surg 2019 Mar 18. Epub 2019 Mar 18.

Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.

Cureus 2019 Jan 8;11(1):e3849. Epub 2019 Jan 8.

Oral and Maxillofacial Surgery, King Saud University, Riyadh, SAU.

Gorlin-Goltz syndrome (GGS) is an infrequent multisystemic disease with an autosomal dominant inherited disorder characterized by the presence of multiple keratocystic odontogenic tumors (KCOT) in the jaws, multiple basal cell nevi carcinomas, and skeletal abnormalities. Early diagnosis of Gorlin-Goltz syndrome is essential as it may progress to aggressive basal cell carcinomas and neoplasias. Gorlin-Goltz syndrome has rarely been reported in Saudi Arabia. Read More