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Dermatol Surg 2019 Feb 7. Epub 2019 Feb 7.

Dermatology and Laser Surgery Center, Houston, Texas West Lake Dermatology, Austin, Texas Dermatology and Laser Surgery Center, Houston, Texas.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, CHU Nantes, Nantes, France.

Early development of extensive acanthosis nigricans (AN) is a key feature in some patients who have hypochondroplasia (HCH) in association with FGFR3 mutations. We here report regarding five new patients with HCH who exhibited AN, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the AN lesions began in childhood, and they were extensive. Read More

Lasers Med Sci 2019 Feb 14. Epub 2019 Feb 14.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.

Becker's nevus is a common pigmented dermatosis, usually featured by ipsilateral pigmented patch with hypertrichosis. Becker's nevus is often treated with various types of lasers although other regimens are available. However, clinical outcomes appear inconsistent among studies. Read More

G Ital Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

First Department of Dermatology, Aristotle University, Thessaloniki, Greece -

Since their first description by Sophie Spitz, Spitz nevi have been a subject of controversy among clinicians for many decades, and remain a clinical conundrum until today as their etiology, morphology, biological behavior and natural evolution is still not totally clear. This is becauase their clinical, dermoscopic and histopathologic features sometimes overlap with those of melanoma, rendering the management of spitzoid lesions particularly difficult. In addition, cases of histopathologically equivocal lesions do exist and their classification might sometimes be very challenging. Read More

Virchows Arch 2019 Feb 12. Epub 2019 Feb 12.

Departement de Biopathologie, Centre Léon Bérard, 28, rue Laennec, 69008, Lyon, France.

Recent advances in genomics have improved the molecular classification of cutaneous melanocytic tumors. Among them, deep penetrating nevi (DPN) and plexiform nevi have been linked to joint activation of the MAP kinase and dysregulation of the β-catenin pathways. Immunohistochemical studies have confirmed cytoplasmic and nuclear expression of β-catenin and its downstream effector cyclin D1 in these tumors. Read More

Endoscopy 2019 Feb 12. Epub 2019 Feb 12.

Department of Endoscopy and Gastroenterology, Pavillon L, Edouard Herriot Hospital, Lyon, France.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China.

Objective: Capsule endoscopy (CE) is a noninvasive diagnostic tool for the digestive tract. We aim to investigate the feasibility and safety of newly-developed magnetically controlled capsule endoscopy (MCE) in children.

Methods: A total of 129 children who underwent MCE in Shanghai Children's Hospital were retrospectively recruited between March 2016 and August 2018. Read More

Open Access Maced J Med Sci 2019 Jan 26;7(2):231-233. Epub 2019 Jan 26.

University of Rome G. Marconi, Rome, Italy.

Aim: To investigate the efficacy of plastic surgery in the treatment of giant congenital melanocytic nevus (GCMN).

Methods: We enrolled 20 patients with 44 lesions and performed one of the following procedures: serial excision, skin grafting, tissue expansion, primary skin closure, distant flap, and adjacent flap. We assessed the outcome at 10 days and 6 months after surgery. Read More

Open Access Maced J Med Sci 2019 Jan 24;7(2):211-213. Epub 2019 Jan 24.

University of Rome G. Marconi, Rome, Italy.

Background: Nevus Sebaceous (NS) is hamartoma predominantly composed of sebaceous glands and is classified as a type of epidermal nevus. In most case, clinical manifestation of NS is typical, so histopathology examination is important only in atypical lesions for its risk of malignancy. Clinical symptoms are plaques or papules (100%), appearing in the head area (100%) with smooth surface (65. Read More

Open Access Maced J Med Sci 2019 Jan 23;7(2):208-210. Epub 2019 Jan 23.

University of Rome G. Marconi, Rome, Italy.

Aim: To assess the efficacy in the treatment of port wine stain in the head and neck by using (Vbeam perfecta®).

Methods: Forty-two port wine stain patients were recruited at the National Hospital of Dermatology and Venereology, Hanoi, Vietnam.

Results: We reported an excellent response (43. Read More

Br J Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Institute for Advanced Biosciences, Univ. of Grenoble Alpes, INSERM U1209 and CNRS UMR5309, 38000, Grenoble, France.

Blue rubber bleb nevus syndrome (BRBN, Bean syndrome) is a rare vascular malformation (VM) characterized by multiple cutaneous and mucous venous defects disseminated throughout the body. An infringement of mucous membranes is possible with potential complications as anemia or hemorrhage. Photoacoustic imaging (PAI) is an emerging technology combining the most compelling features of optical imaging and ultrasound, providing both high optical contrast and high ultrasound resolution at depth in living organisms . Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):207-211

Department of Plastic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P.R.China.

Objective: To explore the effectiveness of modified rhomboid flap for repairing facial skin and soft tissue defect.

Methods: Between January 2016 and May 2018, 23 patients with facial skin and soft defect were repaired by the modified rhomboid flap. There were 10 males and 13 females with the median age of 27 years (range, 11-72 years). Read More

Acta Derm Venereol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Andreas Sygros Hospital 5, Dragoumi street, GR-16121, Athens, Greece.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, University Hospital of Saint-Etienne, 42055 Saint-Etienne Cedex 2, France.

There are only case reports concerning dermoscopy of eyelid margin tumours. We evaluated the clinical and dermoscopic features of 165 eyelid margin tumours of 145 consecutive patients (77 females, 68 males, mean age 64·3 years, standard deviation - SD 17·94, range 10 - 95 years) recruited at the Dermatology Department of the University Hospital of Saint-Etienne, France, between September 1st, 2013 and January 30th, 2017 to exclude malignant tumours. This article is protected by copyright. Read More

PLoS One 2019 6;14(2):e0211318. Epub 2019 Feb 6.

Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland.

This article refers to the Computer Aided Diagnosis of the melanoma skin cancer. We derive wavelet-based features of melanoma from the dermoscopic images of pigmental skin lesions and apply binary C-SVM classifiers to discriminate malignant melanoma from dysplastic nevus. The aim of this research is to select the most efficient model of the SVM classifier for various image resolutions and to search for the best resolution-invariant wavelet bases. Read More

J Cosmet Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, DR RMLH, PGIMER, New Delhi, India.

Nevus of ota is a dermal melanocytosis common among Asian patients, mottled, blue-gray macule that is usually located unilaterally within the distribution of the first and second branches of the trigeminal nerve and almost always responds well to treatment with Q-switched lasers (eg, ruby, alexandrite, and Nd: YAG). In spite of the plethora of science behind laser-tissue interactions, the objective evaluation of nevus of ota response to laser is not on firm footing and most studies report subjective percentile scoring improvement. A knowledge of the variations in morphology of nevus of ota can help predict an optimal dose response and help to counsel patients appropriately. Read More

PLoS One 2019 5;14(2):e0211504. Epub 2019 Feb 5.

Geneseq Biosciences, Melbourne, Australia.

Background: Histopathologic examination of melanocytic neoplasms can be challenging and subjective, with no specific circulating or tissue-based biomarkers currently available. Recently, a circulating 38-microRNA profile of melanoma (Mel38) was described. In this study, Mel38 expression and its impact on downstream mRNA regulation in solid tissue is examined. Read More

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.

Adnexal tumors represent one of the most troublesome differential diagnosis when dealing with skin lesions with clinical and dermoscopic criteria suggestive for basal cell carcinoma (BCC). Among these, benign follicular tumors, and in particular trichoblastoma and trichoepithelioma, deserve a special mention as BCC mimickers. These are benign tumors showing differentiation toward the outer follicular sheath. Read More

J Cutan Pathol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A 36-year-old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Read More

Front Oncol 2018 21;8:675. Epub 2019 Jan 21.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Chuo-ku, Japan.

DNA methylation is considered the primary epigenetic mechanism underlying the development of malignant melanoma. Since DNA methylation can be influenced by environmental factors, it is preferable to compare cancer and normal cells from the same patient. In order to compare the methylation status in melanoma tissues and melanocytes from the same individuals, we employed a novel epidermal sheet cultivation technique to isolate normal melanocytes from unaffected sites of melanoma patients. Read More

Cancers (Basel) 2019 Feb 1;11(2). Epub 2019 Feb 1.

Department of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Hungary.

The incidence of malignant melanoma, one of the deadliest cancers, continues to increase. Here we tested connexin (Cx) expression in primary melanocytes, melanoma cell lines and in a common nevus, dysplastic nevus, and thin, thick, and metastatic melanoma tumor progression series involving the tumor microenvironment by utilizing in silico analysis, qRT-PCR, immunocyto-/histochemistry and dye transfer tests. Primary melanocytes expressed /Cx43, /Cx46 and low levels of /Cx26 and /Cx30. Read More

J Am Acad Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana; Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana. Electronic address:

Background: The presence of nevi portends an increased risk for melanoma.

Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers.

Methods: We evaluated prospective cohorts of 176,317 women (the Nurses' Health Study, 1986-2012 and the Nurses' Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Read More

J Invest Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Beijing Advanced Innovation Center for Genomics (ICG), Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, College of Engineering, Peking-Tsinghua Center for Life Sciences, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and Department of Dermatology, First Hospital, Peking University, Beijing, China. Electronic address:

Acral melanoma (AM) is an extremely aggressive subtype of melanoma that is prevalent in east Asia. AM exhibits high intertumoral and intratumoral heterogeneities with poor prognosis. To associate the genomic heterogeneities with phenotypic traits and efficacy of treatments, a method is needed to recover genomic information from limited samples with high specificity and sensitivity from early stage AM specimens. Read More

Oncotarget 2018 Dec 28;9(102):37733-37752. Epub 2018 Dec 28.

Department of Pathology, University of Helsinki, Helsinki, Finland.

We have previously shown that proto-oncoprotein c-Jun is activated in ornithine decarboxylase (ODC)- and RAS-transformed mouse fibroblasts, and that the transformed morphology of these cells can be reversed by expressing the transactivation domain deletion mutant of c-Jun (TAM67). Here, we found that lysyl oxidase (), encoding an extracellular matrix-modifying enzyme, is downregulated in a c-Jun-dependent manner in ODC-transformed fibroblasts (Odc cells). In addition to , the Lox family members Lox-like 1 and 3 () were found to be downregulated in Odc as well as in RAS-transformed fibroblasts (E4), whereas Lox-like 4 () was upregulated in Odc and downregulated in E4 cells compared to normal N1 fibroblasts. Read More

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

Eur J Dermatol 2018 Dec;28(6):857-859

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Josef-Schneider-Str 2, 97080 Würzburg, Germany.

Int J Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Med Hypotheses 2019 Feb 7;123:98-100. Epub 2019 Jan 7.

Institute of Pathology, Klinikum Augsburg, Augsburg, Germany.

Diagnostic uncertainty is a problem faced daily in clinical medicine. This uncertainty has many guises, such as vague wording in reports or pseudo-exact statements. High rates of intra- and interobserver variability and a corresponding low level of reproducibility are, unfortunately, issues that have to be taken into consideration in many medical fields. Read More

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Department of Dermatology, University of California Davis, School of Medicine, Sacramento, California.

Tattoos present a diagnostic challenge for dermatologists. Various reactions to tattoo have been identified in the literature ranging from allergic, to infectious, to neoplastic. Of the neoplastic cases identified, it is unclear whether the tattoo ink was directly causative, or if the cases were merely coincidence, as the number of cutaneous malignancies has also been on the rise. Read More

Lab Chip 2019 Jan 29. Epub 2019 Jan 29.

Institute of Microelectronics, Peking University, Beijing 100871, China. and National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Beijing 100871, China.

In melanoma surgery, it is difficult to identify residual scattered tumor cells at the surgical margin because of invasive growth. Mohs surgery, widely applied to increase the cure rate and decrease the recurrence rate of melanoma, involves examination of the tissue for tumor cells after tissue removal. Here, we established a liquid biopsy platform for rapid (<5 h), sensitive examination of residual tumor cells at the margin after Mohs surgery using clinical samples from patients with pigment nevus for a demonstration. Read More

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

Section of Oral and Maxillofacial Pathology, University of Connecticut Health Center, 263 Farmington Ave, MC-0925, Farmington, CT, 06030, USA.

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. Read More

Ann Dermatol Venereol 2019 Jan 25. Epub 2019 Jan 25.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.

Introduction: Basaloid follicular hamartoma (BFH) is a rare tumor first described in 1985. It bears clinical and histologic similarities with basal cell carcinoma (BCC), in particular the so-called infundibulocystic form. We performed a single-center clinicopathological study of a series of typical cases of this entity that is occasionally difficult to diagnose. Read More

Am J Dermatopathol 2019 Feb;41(2):85-117

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

After a review of the physiology in the formation and degradation of cutaneous elastic tissue, we describe the clinicopathologic disorders characterized by increased and decreased cutaneous elastic tissue. Cutaneous disorders characterized by increased and/or abnormal elastic tissue in the dermis include elastoma, also named nevus elasticus, dermatosis lenticularis disseminata, pseudoxanthoma elasticum, late-onset focal dermal elastosis, linear focal elastosis, elastoderma, elastofibroma dorsi, and elastosis perforans serpiginosa. In some of these conditions, the specific histopathologic diagnosis may be rendered with hematoxylin-eosin stain, whereas in other ones special elastic tissue stains are necessary to demonstrate the anomalies. Read More

Photodermatol Photoimmunol Photomed 2019 Jan 28. Epub 2019 Jan 28.

The Department of Dermatology, Zealand University Hospital Roskilde, Denmark.

Background: The risk of photoaging and actinic keratosis caused by work related solar ultraviolet radiation exposure has not previously been investigated in Nordic countries. The objectives of this study was to describe the occurrence of photoaging, actinic keratosis and keratinocyte cancer in a population of Danish outdoor and indoor workers, and investigate the association between these clinical findings and semi-objective measures of work related solar ultraviolet radiation exposure in the same population.

Methods: A clinical cross-sectional study of the occurrence of facial wrinkles, actinic keratosis, keratinocyte cancer and melanocytic nevi in a population of Danish outdoor and indoor workers and associations with semi-objective measures of work related solar ultraviolet radiation exposure based on a combination of dosimetry and self-report. Read More

Vet Pathol 2019 Jan 27:300985818823667. Epub 2019 Jan 27.

1 Optivet Referrals, Havant, Hampshire, UK.

This report describes the clinical presentation, diagnosis, and histopathologic features of oculodermal melanocytosis in a young dog. A 3-year-old male neutered Labrador Retriever presented with conjunctival and scleral hyperpigmentation of the right eye, with concurrent ipsilateral cutaneous hyperpigmentation involving the right side of the face. Initial skin and conjunctival biopsies revealed an accumulation of histologically benign melanocytes within the dermis and conjunctival stroma, respectively. Read More

Burns 2019 Jan 23. Epub 2019 Jan 23.

Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Tissue expanders (TE) are frequently used worldwide. In this study we surveyed outcome of our patients retrospectively during 15 years.

Materials And Methods: We had 1105 patients for whom 3059 TEs have been used. Read More

Oncogene 2019 Jan 24. Epub 2019 Jan 24.

Université de Lyon, F-69003, Lyon, France.

Due to its high proclivity to metastasize, and despite the recent development of targeted and immune therapy strategies, melanoma is still the deadliest form of skin cancer. Therefore, understanding the molecular mechanisms underlying melanoma invasion remains crucial. We previously characterized Tspan8 for its ability to prompt melanoma cell detachment from their microenvironment and trigger melanoma cell invasiveness, but the signaling events by which Tspan8 regulates the invasion process still remain unknown. Read More

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

University of Mississippi Medical Center School of Medicine, Department of Dermatology, and Department of Pathology, Jackson, Mississippi.

A young man presented with blue nodules on the trunk, face, and extremities that gradually increased in number and size. His mother had similar lesions. Initially, blue rubber bleb nevus syndrome was suspected, but histological findings confirmed the diagnosis of hereditary glomuvenous malformations. Read More

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

Cutaneous mucinosis of infancy (CMI) is a rare dermatologic condition, first reported in 1980 and currently classified within the complex group of papular mucinoses. We report a case of CMI and review the prior 13 cases in the literature. The patient was a 5-year-old girl who presented with asymptomatic dermal papules and plaques on her leg and back with no overlying color change. Read More

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Department of Plastic & Reconstructive Surgery, Galway University Hospital, Galway.

We describe a useful strategy to accurately identify the correct 'atypical' nevus for excision in patients with multiple nevi. We believe this is an effective strategy and eliminates risk of any incorrect procedures being performed, and have used this technique on over 50 patients to date. As the patient stores the images on their own phone, there is no breach of data protection. Read More

PLoS One 2019 24;14(1):e0210077. Epub 2019 Jan 24.

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis. FXR, a member of the metabolic nuclear receptor family, is markedly down-regulated in human CCA. Read More

Ocul Oncol Pathol 2019 Jan 27;5(1):8-12. Epub 2018 Apr 27.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

We report two patients who developed a second distinct choroidal melanoma in the same eye following successful regression of their first choroidal melanoma after iodine-125 plaque brachytherapy. Neither patient demonstrated ocular melanocytosis, local tumor recurrence, or vitreous seeding. One patient had the second tumor arising from a previously documented choroidal nevus, and after undergoing enucleation, there was no detectable connection between the tumors on histopathologic examination. Read More

Biomark Res 2019 14;7. Epub 2019 Jan 14.

Department of Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA.

Factors regulating transcription of pluripotency genes in congenital nevo-melanocytes are not known. Nevo-melanocytes belong somewhere in-between the ends of a spectrum where the normal epidermal melanocyte represents one end and a melanoma cell with multiple genetic abnormalities represents the other. Cells from large/giant congenital nevi (L/GCMN), unlike normal melanocytes, grow colonies on soft agar and express pluripotency markers, similar to melanoma cells. Read More

Melanoma Res 2019 Jan 21. Epub 2019 Jan 21.

Cutaneous amelanotic melanoma (AM) is a rare amelanotic or a hypomelanotic subtype of melanoma, comprising only 0.4-27.5% of all melanoma cases. Read More

Pigment Cell Melanoma Res 2019 Jan 23. Epub 2019 Jan 23.

Department of Pathology, Stanford University Medical Center, Stanford, California.

Head Neck Pathol 2019 Jan 22. Epub 2019 Jan 22.

Atlanta Oral Pathology, Emory Decatur Hospital, Emory University School of Medicine, 2701 N. Decatur Road, Decatur, GA, 30033, USA.

White lesions of the oral cavity are quite common and can have a variety of etiologies, both benign and malignant. Although the vast majority of publications focus on leukoplakia and other potentially malignant lesions, most oral lesions that appear white are benign. This review will focus exclusively on reactive white oral lesions. Read More

Eur J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo.

Background: Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed.

Objectives: To present two cases of congenital nevi with hypomelanosis and superficial fine scales. Read More

J Cutan Pathol 2019 Jan 21. Epub 2019 Jan 21.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Accurate classification of spitzoid melanocytic lesions is difficult due to overlapping clinical and histopathologic features between Spitz nevi, atypical Spitz tumors (ASTs), and spitzoid melanomas. Expression of p16 (CDKN2A) has been used as a marker of spitzoid lesions. However, its expression may be variable. Read More

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

We present here two-term neonates presenting with right lower limb hypertrophy, a port-wine stain, acral abnormalities and clubfeet. These neonates had overlapping features of Klippel Trenaunay syndrome and congenital lipomatous overgrowth, vascular malformation, epidermal nevi and scoliosis/skeletal abnormalities. Such overgrowth syndrome has not been previously described in the literature. Read More

J Clin Med 2019 Jan 17;8(1). Epub 2019 Jan 17.

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon 164, Korea.

Congenital melanocytic nevi need surgical excisions. However, the effect of the size and location of the nevi on pain and emergence agitation have yet to be studied. The objective of this study was to evaluate (1) the ideal parameter of the nevus size and (2) the effects of the size and location of the nevus on pain and emergence agitation. Read More