21,939 results match your criteria Nevi of Ota and Ito


Correlation of serum tryptase levels with total number of nevi, Breslow thickness, ulceration, and mitotic index in melanoma patients: evaluation of a promising prognostic marker.

Melanoma Res 2018 Dec 15. Epub 2018 Dec 15.

Dermatologic Clinic, Departement of Internal Medicine and Medical Specialties, La Sapienza University of Rome.

Current evidences suggest that mast cells contribute to the proliferation and differentiation of skin melanocytes. According to these findings, we carried out an observational cross-sectional study to investigate the correlation between the total number of nevi (TN), Breslow thickness (BT), and serum tryptase (ST) levels in a cohort of 35 melanoma (MM) patients. A Mann-Whitney test was performed to compare ST values within each variable. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000561DOI Listing
December 2018
1 Read

Eruptive melanocytic nevi in a patient with Parkinson disease treated by carbidopa-levodopa.

JAAD Case Rep 2019 Jan 4;5(1):21-23. Epub 2018 Dec 4.

Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280631PMC
January 2019

Using a car phone holder for performing oculoscopy with a universal serial bus dermatoscope.

J Am Acad Dermatol 2019 Jan;80(1):e1-e2

Department of Dermatology and STD, University College of Medical Sciences and GTB Hospital, Delhi, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183228
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http://dx.doi.org/10.1016/j.jaad.2018.07.011DOI Listing
January 2019
1 Read

Current controversies in early-stage melanoma: Questions on incidence, screening, and histologic regression.

J Am Acad Dermatol 2019 Jan;80(1):1-12

Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah. Electronic address:

In the first article in this continuing medical education series we review controversies and uncertainties relating to the epidemiology and initial diagnosis of localized cutaneous melanoma (ie, stage 0, I, or II). Many of these issues are unsettled because of conflicting evidence. Melanoma incidence appears to be increasing, yet its basis has not been fully explained. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.03.053DOI Listing
January 2019
2 Reads

NRAS Q61R and BRAF G466A Mutations in Atypical Melanocytic Lesions Newly Arising in Advanced Melanoma Patients Treated with Vemurafenib.

J Cutan Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations.

Methods: We identified three severely dysplastic nevi, one atypical intraepidermal melanocytic proliferation, and four melanoma in situ lesions, newly arising in four patients undergoing treatment with vemurafenib. To characterize mutations in these atypical melanocytic lesions, we used a custom iPlex panel detecting 74 mutations in 13 genes known to play a role in melanoma pathogenesis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13401
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http://dx.doi.org/10.1111/cup.13401DOI Listing
December 2018
18 Reads

Site-specific acral nevus histologically reminiscent of melanoma: Recognition of the utility of the Fontana-Masson stain.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

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http://dx.doi.org/10.1111/1346-8138.14735DOI Listing
December 2018

Histopathologic correlation of high-risk MelaFind lesions: a 3-year experience from a high-risk pigmented lesion clinic.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: A significant number of pigmented lesions are biopsied to rule out melanoma, but most will be benign. MelaFind is a highly sensitive, noninvasive computer-assisted system to aid in clinical diagnosis of melanoma.

Methods: A total of 140 high-risk patients were followed by one expert dermatologist. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14336
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http://dx.doi.org/10.1111/ijd.14336DOI Listing
December 2018
1 Read

Is blister grafting an acceptable answer to treating nevus depigmentosus?

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Dermatology, College of Medicine, King Faisal University, Al Ahsa, Saudi Arabia.

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http://dx.doi.org/10.1111/ijd.14354DOI Listing
December 2018

Detection of a multi-lineage mosaic NRAS mutation c.181C>A (p.Gln61Lys) in an individual with a complex congenital nevus syndrome.

Pigment Cell Melanoma Res 2018 Dec 7. Epub 2018 Dec 7.

Institute of Human Genetics, University Hospital Otto-von-Guericke-University, Magdeburg, German.

Mosaic RASopathies constitute a clinically and genetically heterogeneous group of non-inherited congenital (neuro)cutaneous disorders caused by postzygotic mutations in genes encoding components of the RAS-MAPK signaling pathway (Luo & Tsao, 2014). There are striking genotype-phenotype correlations within this group but also clinical features overlapping between distinct disorders. Congenital melanocytic nevi (CMN) are the most common lesions falling into the category of mosaic RASopathies. Read More

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http://dx.doi.org/10.1111/pcmr.12761DOI Listing
December 2018

[Melanonychia].

Ugeskr Laeger 2018 Dec;180(50)

Melanonychia is seen, when melanin is incorporated in the nail, which gives a band of dark discolouration of the nail. Nail discolouration is a common cause for patients to seek medical attention, and it is often benign. Melanonychia can be seen due to melanocytic proliferation (ungual naevi), benign hyperplasia (lentigo) and hypermelanosis (infections, traumas). Read More

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December 2018

Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2018 Dec 13. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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http://link.springer.com/10.1007/s00403-018-1885-x
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http://dx.doi.org/10.1007/s00403-018-1885-xDOI Listing
December 2018
1 Read

Factors associated with suspected nonmelanoma skin cancers, dysplastic nevus, and cutaneous melanoma among first-time SPOTme screening program participants (2009-2010).

J Am Acad Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address:

Background: There have been no studies of the American Academy of Dermatology's SPOTme skin cancer screening program that have collectively analyzed the factors associated with suspected diagnoses of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), dysplastic nevus (DN), and cutaneous melanoma (CM).

Objective: Describe the demographics, risk factors, and access to care profile associated with suspected diagnoses of BCC, SCC, DN, and CM among first-time SPOTme screenees from 2009 to 2010.

Methods: We conducted a cross-sectional analysis of data from SPOTme skin cancer screenings conducted in 2009 and 2010. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.010DOI Listing
December 2018

MicroRNA-373 promotes cell migration via targeting salt-inducible kinase 1 expression in melanoma.

Exp Ther Med 2018 Dec 21;16(6):4759-4764. Epub 2018 Sep 21.

Department of Plastic Surgery, The Third People's Hospital of Hubei Province, Wuhan, Hubei 430033, P.R. China.

It is well established that altered expression of microRNAs (miRs) is critical in numerous human cancer types. Nevertheless, the molecular mechanisms of many miRs are yet to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reaction and western blot analyses, and cell migration assays were performed to verify dysregulation of miR-373 in melanoma and its biological function. Read More

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http://dx.doi.org/10.3892/etm.2018.6784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257786PMC
December 2018

Combination of multimodal imaging features predictive of choroidal nevus transformation into melanoma.

Br J Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Aim: To characterise combinations of multimodal imaging risk factors and predictive value for choroidal nevus transformation into melanoma.

Methods: This is a retrospective review of multimodal imaging features for 3806 choroidal nevi from 1 January 2007 through 1 January 2017. Kaplan-Meier estimates and Cox regression analyses were used to calculate 5-year percentages of growth to melanoma and HR. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312967DOI Listing
December 2018

Optical coherence tomography imaging of melanoma skin cancer.

Lasers Med Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

No consensus guidelines exist on the use of optical coherence tomography (OCT) for diagnosis of cutaneous melanoma. The objectives of this review are to provide a descriptive review of the literature on characteristics of cutaneous melanomas seen on high-definition OCT (HD-OCT), speckle variance OCT (SV-OCT), and conventional OCT and to compare their diagnostic ability with that of histopathology. A review of PubMed and Google Scholar identified all available literature on OCT in melanoma skin cancer that included all in vivo and ex vivo studies on human or human tissues and excluded all studies on non-human subjects or animal studies. Read More

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http://dx.doi.org/10.1007/s10103-018-2696-1DOI Listing
December 2018
2 Reads

Blue Rubber Bleb Nevus Syndrome: A Possible Cause for Growth Retardation and Pubertal Delay.

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Objective: To describe a rare case of Blue Rubber Bleb Nevus (BRBNS) with growth retardation and pubertal delay.

Clinical Presentation And Intervention: A 16-year-old boy with severe iron deficiency anemia was diagnosed with BRBNS, showing growth retardation and pubertal delay simultaneously. The patient was treated conservatively with intravenous iron therapy and his puberty advanced gradually. Read More

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http://dx.doi.org/10.1159/000496105DOI Listing
December 2018

GNAQ Mutations in Diffuse and Solitary Choroidal Hemangiomas.

Ophthalmology 2018 Dec 8. Epub 2018 Dec 8.

Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical Center, New York, NY.

Purpose: GNAQ mutations have been identified in port wine stains (both syndromic and non-syndromic) and melanocytic ocular neoplasms. This study investigates the presence of GNAQ mutations in diffuse- (those associated with Sturge-Weber syndrome (SWS)) and solitary choroidal hemangiomas.

Participants: Tissue from 11 patients with the following diagnoses: port wine stain (n = 3), diffuse choroidal hemangioma (n = 1), solitary choroidal hemangioma (n = 6), choroidal nevus (n =1) METHODS: Ten specimens were interrogated with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT), a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 468 key cancer genes in formalin-fixed, paraffin-embedded tumors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183258
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http://dx.doi.org/10.1016/j.ophtha.2018.12.011DOI Listing
December 2018
2 Reads

Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.

Br J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.

Background: Reprogramming of energy metabolism to enhanced aerobic glycolysis has been defined as a hallmark of cancer.

Objective: To investigate the role of the mitochondrial proteins, β-subunit of the H -ATP synthase (β-F1-ATPase), and heat-shock protein 60 (HSP60), and the glycolytic markers, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase M2 (PKM2), as well as the bioenergetic cellular (BEC) index, in melanoma progression.

Material And Methods: The expression of energy metabolism proteins were assessed on a set of different melanoma cells representing the natural biological history of the disease: primary cultures of melanocytes, radial (WM35) and vertical (WM278) growth phases, and poorly (C81-61-PA) and highly (C8161-HA) aggressive melanoma cells. Read More

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http://dx.doi.org/10.1111/bjd.17513DOI Listing
December 2018
3 Reads

Regression of multiple melanocytic nevi associated with nivolumab treatment for metastatic melanoma.

Int J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Clinical University Hospital of Valencia, Valencia, Spain.

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http://dx.doi.org/10.1111/ijd.14340DOI Listing
December 2018
1 Read

Electrodissection for Nevus Lipomatosus Cutaneous Superficialis Removal.

J Am Acad Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Chief and profesor for dermatology department; Place where work was done: Universidad Autonoma de Nuevo León, Facultad de Medicina, Hospital Universitario ''Dr. José E. González'' Servicio de Dermatología, Monterrey, NL, México. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.11.051DOI Listing
December 2018

Identification of a robust methylation classifier for cutaneous melanoma diagnosis.

J Invest Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.

Early diagnosis improves melanoma survival, yet the histopathological diagnosis of cutaneous primary melanoma can be challenging even for expert dermatopathologists. Analysis of epigenetic alterations, such as DNA methylation, that occur in melanoma can aid in its early diagnosis. Using a genome-wide methylation screen, we assessed CpG methylation in a diverse set of 89 primary invasive melanomas, 73 nevi, and 41 melanocytic proliferations of uncertain malignant potential, classified based on interobserver review by dermatopathologists. Read More

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http://dx.doi.org/10.1016/j.jid.2018.11.024DOI Listing
December 2018

Dermoscopic evaluation of melanocytic nevi changes after photoepilation techniques: a prospective study.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Clinic - Department of Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.

Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known.

Objective: Prospective study on clinical and dermatoscopic effects of photoepilation on melanocytic nevi.

Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up program from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Read More

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http://dx.doi.org/10.1111/jdv.15388DOI Listing
December 2018
1 Read

Pigmented skin lesions displaying regression features: dermoscopy and reflectance confocal microscopy criteria for diagnosis.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.

Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Methods: Observational retrospective study. Read More

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http://doi.wiley.com/10.1111/exd.13853
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http://dx.doi.org/10.1111/exd.13853DOI Listing
December 2018
4 Reads

A diagnostically-challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23-gene expression signature (myPath Melanoma).

J Cutan Pathol 2018 Dec 2. Epub 2018 Dec 2.

Geisel School of Medicine at Dartmouth, Hanover, NH.

Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hybridization were used to arrive at the correct diagnosis. Read More

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http://doi.wiley.com/10.1111/cup.13400
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http://dx.doi.org/10.1111/cup.13400DOI Listing
December 2018
2 Reads

Giant congenital facial melanocytic nevus.

Oman J Ophthalmol 2018 Sep-Dec;11(3):265-266

Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Giant Congenital Melanocytic Nevus (GCMNs) is mostly reported in area of trunk followed by limbs and head. Their incidence is <1:20,000 newborns It derives attention due to its association with malignant melanoma.The risk of developing malignant melanoma is between 5 to 10%. Read More

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http://dx.doi.org/10.4103/ojo.OJO_216_2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219340PMC
December 2018
1 Read

Spontaneous Regression of Large Congenital Melanocytic Nevi, With a Halo Rim in 17 Children With Large Scalp and Trunk Nevi During 45 Years: A Review of the Literature.

Clin Pediatr (Phila) 2018 Dec 3:9922818816421. Epub 2018 Dec 3.

1 University of Miami, Miami, FL, USA.

Background: Prior reports on large congenital melanocytic nevi (LCMN) do not provide a clear management approach to physicians to advise parents or patients. Whether the presence of a halo around the nevus can guide management has not been fully explored.

Design: Children born with an LCMN were observed without active intervention. Read More

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http://dx.doi.org/10.1177/0009922818816421DOI Listing
December 2018
1 Read

[miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1360-1365

Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China.

Objective: To investigate the expression profile of miR-122-5p in melanoma tissues and the effect of miR-122-5p on the proliferation, cell cycle and apoptosis of human melanoma cell lines SK-MEL-110 and A375.

Methods: The expression profiles of miR-122-5p in melanoma and pigmented nevus tissues were detected using real-time fluorescence quantitative PCR (qRT-PCR). SK-MEL-110 and A375 cells transfected with miR-122-5p inhibitor or negative control inhibitor (NC) I were examined for miR-122- 5p expression using qRT-PCR and changes in cell proliferation, cell cycle and apoptosis using MTT assay or flow cytometry. Read More

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http://www.j-smu.com/oa/darticle.aspx?type=view&id=20181
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http://dx.doi.org/10.12122/j.issn.1673-4254.2018.11.14DOI Listing
November 2018
5 Reads

Segmental epidermal nevus and mucosal neuromas associated with -related overgrowth spectrum disorder.

JAAD Case Rep 2018 Nov 14;4(10):1080-1082. Epub 2018 Nov 14.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

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http://dx.doi.org/10.1016/j.jdcr.2018.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250901PMC
November 2018

Bilateral Iris Mammillations in Amblyopic Eyes without Oculodermal Melanocytosis or Neurofibromatosis.

Case Rep Ophthalmol Med 2018 29;2018:2534042. Epub 2018 Oct 29.

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

Purpose: Iris mammillations are related to oculodermal melanosis and iris nevi. We report a rare case of bilateral simple iris mammillations without ocular melanosis or systemic neuronal disorders.

Case Report: A healthy 10-year-old Japanese girl was found incidentally to have bilateral iris mammillations while being treated for amblyopia. Read More

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http://dx.doi.org/10.1155/2018/2534042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231380PMC
October 2018
1 Read

Identification of the potential prognostic genes of human melanoma.

J Cell Physiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Musculoskeletal Cancer Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China.

The melanoma is one of the most dangerous forms of skin diseases. It may spread to other parts of the body and cause serious illness and death. Early detection and diagnosis are crucial. Read More

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http://dx.doi.org/10.1002/jcp.27668DOI Listing
November 2018

Primary cutaneous apocrine carcinoma arising within a nevus sebaceus.

Cutis 2018 Oct;102(4):291-294

Nova Southeastern University College of Osteopathic Medicine/Largo Medical Center, Florida, USA.

Nevus sebaceus (NS)(organoid nevus) is a benign follicular neoplasm that commonly occurs on the scalp, face, or neck. With time, it may give rise to benign or malignant tumors such as trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma (BCC). Rarely, other types of neoplasms may develop. Read More

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October 2018
2 Reads

Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Laboratory Medicine, Tongji hospital of Tongji University, Shanghai, China.

Objective: To investigate the effect of microRNA-137 (miR-137) on the migration and invasion of melanoma cells and its mechanism.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-137 in melanoma tissues and cells. miR-137 mimics, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) small interfering RNA and corresponding controls were transfected into A375 and WM451 cells by lipofection. Read More

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http://dx.doi.org/10.1002/jcb.28124DOI Listing
November 2018
1 Read

Case for diagnosis. Ulcerated intradermal nevus simulating Sister Mary Joseph's nodule.

An Bras Dermatol 2018 Nov/Dec;93(6):905-906

Dermatology Service, Hospital do Servidor Público do Estado de São Paulo, São Paulo (SP), Brazil.

We report a case of a 76-year-old patient with a history of recent weight loss and ulcerated umbilical nodular lesion. Initially, we considered the diagnostic hypothesis of Sister Mary Joseph's nodule. However, histopathological evaluation revealed that it was an ulcerated intradermal nevus. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256221PMC

NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Braz J Med Biol Res 2018 Nov 23;52(1):e7952. Epub 2018 Nov 23.

Department of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. Read More

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http://dx.doi.org/10.1590/1414-431X20187952DOI Listing
November 2018

Spontaneous Regression of Medium-Sized Congenital Melanocytic Nevi: Report of 3 New Cases.

Actas Dermosifiliogr 2018 Oct 25. Epub 2018 Oct 25.

Centro Integral de Dermatología, Tucumán, Argentina.

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http://dx.doi.org/10.1016/j.ad.2018.03.023DOI Listing
October 2018

Use of Telehealth Screening to Detect Diabetic Retinopathy and Other Ocular Findings in Primary Care Settings.

Telemed J E Health 2018 Nov 27. Epub 2018 Nov 27.

1 Wills Eye Hospital, Thomas Jefferson University , Philadelphia, Pennsylvania.

Purpose: To determine the incidence of diabetic retinopathy (DR) and other ocular findings in previously diagnosed diabetes using telehealth retinal screening with nonmydriatic fundus photography (nFP) in primary care physicians' offices.

Methods: A retrospective study based on electronic chart review was performed. All diabetic patients who participated in the Wills Eye Hospital (WEH) telehealth retinal screening program from July 1, 2012 to February 20, 2017 were included. Read More

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http://dx.doi.org/10.1089/tmj.2018.0016DOI Listing
November 2018
2 Reads

Impact of clinical and personal data in the dermoscopic differentiation between early melanoma and atypical nevi.

Dermatol Pract Concept 2018 Oct 31;8(4):324-327. Epub 2018 Oct 31.

Dermatology Division, Department of Medical, Surgical and NeuroSciences, University of Siena, Siena, Italy.

Background: Differential diagnosis of clinically atypical nevi (aN) and early melanomas (eMM) still represents a challenge even for experienced dermoscopists, as dermoscopy alone is not sufficient to adequately differentiate these equivocal melanocytic skin lesions (MSLs).

Objectives: The objectives of this study were to investigate what were the most relevant parameters for noninvasive differential diagnosis between eMM and aN among clinical, personal, and dermoscopic data and to evaluate their impact as risk factors for malignancy.

Methods: This was a retrospective study performed on 450 MSLs excised from 2014 to 2016 with a suspicion of malignancy. Read More

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http://dx.doi.org/10.5826/dpc.0804a16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246054PMC
October 2018
3 Reads

Challenging clinical diagnosis of 2 lesions on the back: dermoscopy gives the clue.

Dermatol Pract Concept 2018 Oct 31;8(4):320-321. Epub 2018 Oct 31.

Department of Dermatology, Hospital Clínico San Carlos, Madrid, Spain.

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http://dx.doi.org/10.5826/dpc.0804a14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246065PMC
October 2018
1 Read

Clinicopathologically problematic melanocytic tumors: a case-based review.

Dermatol Pract Concept 2018 Oct 31;8(4):306-313. Epub 2018 Oct 31.

Anatomic Pathology Unit, Hospital of Macerata, Italy.

Background: In spite of recent advances in the histopathological and molecular diagnosis of melanocytic neoplasms, a certain proportion of these lesions remain a daunting challenge for both the clinician and the pathologist.

Objectives: To emphasize the importance of close collaboration between clinicians and pathologists in case of problematic melanocytic lesions.

Patients: We report and discuss 5 problematic scenarios of melanocytic lesions, including tumoral melanosis, nevoid melanoma, lentiginous melanoma, spitzoid melanoma and BAPoma that may pose diagnostic difficulties in our practice. Read More

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http://dx.doi.org/10.5826/dpc.0804a12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246059PMC
October 2018
1 Read

Regressing Conjunctival Nevus in a Child.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):501-503

Liverpool Ocular Oncology Centre, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, England, UK.

Purpose: To report a case exhibiting drastic regression of a conjunctival nevus in a child.

Case Report: Spontaneous regression of conjunctival nevus is uncommon. We report the case of a nine-year-old Caucasian boy presenting a conjunctival-pigmented lesion situated at the plica semilunaris that underwent a significant reduction in size and color over a period of 15 months. Read More

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http://dx.doi.org/10.4103/jovr.jovr_215_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210859PMC
November 2018
3 Reads

Association of Phenotypic Characteristics and UV Radiation Exposure With Risk of Melanoma on Different Body Sites.

JAMA Dermatol 2018 Nov 21. Epub 2018 Nov 21.

Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Importance: Two pathways have been hypothesized for the development of cutaneous melanoma: one typically affects the head and neck, a site with chronic sun damage, and the other affects the trunk, which is less exposed to the sun. However, the possible cause of limb melanomas is less studied under this hypothesis.

Objective: To investigate the association between phenotypic characteristics, pattern of UV radiation exposure, and risk of melanoma on different body sites. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.3964DOI Listing
November 2018
3 Reads

Distinct Genomic Patterns in Pigmented Epithelioid Melanocytoma: A Molecular and Histologic Analysis of 16 Cases.

Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.

Dermatology, Feinberg School of Medicine, Northwestern University.

Pigmented epithelioid melanocytoma (PEM) is considered an intermediate grade melanocytic lesion that is histologically indistinguishable from epithelioid blue nevi associated with Carney complex. PEM are characterized by an intradermal population of heavily pigmented epithelioid-shaped melanocytes along with some spindled and dendritic melanocytes with frequent melanophages. These melanocytic tumors occasionally involve regional lymph nodes but only rarely result in distant metastases. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001195DOI Listing
November 2018
4 Reads

Genetic variant in the NSDHL gene in a cat with multiple congenital lesions resembling inflammatory linear verrucous epidermal nevi.

Vet Dermatol 2018 Nov 25. Epub 2018 Nov 25.

Institute of Genetics, Vetsuisse Faculty, University of Bern, Länggassstrasse 120, 3001, Bern, Switzerland.

Background: The feline counterpart of human inflammatory linear verrucous epidermal nevus (ILVEN) has been described; however, the possible underlying developmental defect has not been investigated.

Objective: To report a case of multiple ILVEN-like lesions in a cat with a genetic variant in the NSDHL gene.

Animals: A 2-year-old, female, domestic short hair cat with a history of multiple alopecic, verrucous, hyperpigmented and erythematous skin lesions, following Blaschko's lines on the head, the limbs, the trunk and paw pads. Read More

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http://dx.doi.org/10.1111/vde.12699DOI Listing
November 2018
3 Reads

Bilateral Phacomatosis Pigmentovascularis in a Young Male with Developmental Glaucoma and Varicose Veins.

J Curr Glaucoma Pract 2018 May-Aug;12(2):94-98. Epub 2018 Aug 1.

Senior Resident, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.

Aim: To report a case of bilateral phacomatosis pigmentovascularis (PPV), in a young male,presenting with developmental glaucoma and high myopia along with systemic features of klippel trenanauy weber (KTW) syndrome.

Background: The co-existence of oculodermal melanocytosis (ODM)and port-wine stain was termed PPV by Ota. Port-wine stain presents as part of Sturge-Weber syndrome (SWS). Read More

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http://www.jaypeejournals.com/eJournals/ShowText.aspx?ID=147
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http://dx.doi.org/10.5005/jp-journals-10008-1251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236123PMC
August 2018
3 Reads

Clinical features and outcomes of spitzoid proliferations in children and adolescents.

Br J Dermatol 2018 Nov 22. Epub 2018 Nov 22.

Harvard Medical School.

Background: Spitzoid proliferations range from Spitz nevi to melanomas, and there are few studies describing clinical features and outcomes in the pediatric population.

Objectives: Determine clinical features and outcomes of a large pediatric cohort with histopathologically-confirmed Spitz tumors.

Methods: Retrospective cohort study of Boston Children's Hospital patients younger than 20 years with a histopathologic diagnosis of spitzoid proliferation from 1/1/1994 - 10/23/2012. Read More

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http://dx.doi.org/10.1111/bjd.17450DOI Listing
November 2018
2 Reads

Late-Onset Nevus Comedonicus With Follicular Epidermolytic Hyperkeratosis-Case Report and Review of the Literature.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Nevus comedonicus is a rare cutaneous follicular hamartoma, characterized by the clustering of papules with firm, blackened horny buffers. It is usually present at birth or during childhood, although few cases of late-onset disease have been described. We present a case of postmenopausal-onset nevus comedonicus in a 55-year-old white woman without relevant medical history. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001317DOI Listing
November 2018
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Proliferating Neurocristic Hamartoma Arising in a Giant Congenital Nevus: Comparative Genomic Hybridization Findings.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Deramatology, Hospital Universitario 12 de Octubre, Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain.

Neurocristic cutaneous hamartomas (NCHs) are rarely reported tumors with divergent differentiation derived from persistently active pluripotent cells from the neural crest. They result from aberrant development of the neuromesenchyme, and they can express fibrogenic, melanocytic, and/or neurosustentacular differentiation. Thus, congenital melanocytic nevus also represents a neurocristic dysplasia of the skin in which cells are melanogenic cells arrested in development located in the reticular dermis, and nodular proliferative neurocristic hamartoma may arise within a congenital melanocytic nevus. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001319DOI Listing
November 2018

NFAT1 enhances the effects of tumor-associated macrophages on promoting malignant melanoma growth and metastasis.

Biosci Rep 2018 Nov 20. Epub 2018 Nov 20.

Xiangya Hospital, Central South University, Changsha, China

Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. NFAT1 has been shown to promote melanoma growth and metastasis in vivo. We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties. Read More

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http://dx.doi.org/10.1042/BSR20181604DOI Listing
November 2018
4 Reads

Fusing fine-tuned deep features for skin lesion classification.

Comput Med Imaging Graph 2018 Nov 3;71:19-29. Epub 2018 Nov 3.

School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.

Malignant melanoma is one of the most aggressive forms of skin cancer. Early detection is important as it significantly improves survival rates. Consequently, accurate discrimination of malignant skin lesions from benign lesions such as seborrheic keratoses or benign nevi is crucial, while accurate computerised classification of skin lesion images is of great interest to support diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08956111183060
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http://dx.doi.org/10.1016/j.compmedimag.2018.10.007DOI Listing
November 2018
9 Reads