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J Digit Imaging 2020 Jun 30. Epub 2020 Jun 30.

Department of Electronics and Communication, Faculty of Engineering, Zagazig University, Zagazig 44519, Egypt.

Melanoma is deadly skin cancer. There is a high similarity between different kinds of skin lesions, which lead to incorrect classification. Accurate classification of a skin lesion in its early stages saves human life. Read More

J Craniofac Surg 2020 Jun 24. Epub 2020 Jun 24.

Department of Otolaryngology, Head and Neck Surgery, Gulhane Medical School, Ankara, Turkey.

Objective: The postauricular region (PR) is an anatomic area that has been neglected until now, due to the fact that the significant cosmetic changes and features of this region are often overlooked. There are limited and inconsistent data about postauricular masses in the literature and the definition of the PR and its borders remain unclear. The aim of the present study was to define the PR and evaluate benign and malignant masses that may arise in the PR. Read More

Dermatol Surg 2020 Jun 25. Epub 2020 Jun 25.

All authors are affiliated with the Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Whether picosecond lasers outperform Q-switched lasers in treating pigmented lesions has not been clearly evaluated.

Objective: To compare the efficacy and safety of picosecond and Q-switched lasers in treating epidermal and dermal pigmented lesions in Asians.

Methods: Eight subjects with lentigines and 6 subjects with acquired bilateral nevus of Ota-like macules were enrolled. Read More

J Surg Oncol 2020 Jun 29. Epub 2020 Jun 29.

Departments of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

Background: With the approval of adjuvant therapy for stage III melanoma, accurate staging is more important than ever. Sentinel node biopsy (SNB) is an accurate staging tool, yet the presence of capsular nevi (CN) can lead to a false-positive diagnosis.

Patients And Methods: Retrospective analysis of the American Joint Committee on Cancer 7th edition stage IIIA melanoma patients who were treated at our institute between 2000 and 2015. Read More

J Dtsch Dermatol Ges 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, Medical University of Graz, Graz, Austria.

Background And Objectives: The incidence of melanoma is rising and prevention plays an important role. Multiple nevi as well as a medical history of melanoma are important risk factors. In affected patients, a two-step algorithm consisting of total-body photography (TBP) and sequential digital dermatoscopy (SDD) is a helpful diagnostic tool. Read More

Arch Dermatol Res 2020 Jun 28. Epub 2020 Jun 28.

Department of Plastic Surgery, Herlev and Gentofte University Hospital, Herlev Ringvej 75, Herlev, 2730, Copenhagen, Denmark.

Differentiating between benign and malignant skin lesions can be very difficult and should only be done by sufficiently trained and skilled clinicians. To our knowledge there are no validated tests for reliable assessments of clinicians' ability to perform skin cancer diagnostics. To develop and gather validity evidence for a test in skin cancer diagnostics, a multiple-choice questionnaire (MCQ) was developed based on informal interviews with seven content experts from five skin cancer centers in Denmark. Read More

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):446-450

Institute of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan Remains (Organs) Donation Registration and Skin Receiving Station, Wuhan 430060, China.

To investigate the causes of death and etiological characteristics of skin tissue donors, and to provide reference for allogeneic skin transplantation. From October 2008 to October 2018, 49 skin tissue donors accepted by the Burn Department of Wuhan Third Hospital met the inclusion criteria of this study, and a cross-sectional study was conducted. According to the cause of death, the donors were divided into accidental death group (19 cases) and non-accidental death group (30 cases). Read More

J Cosmet Dermatol 2020 Jun 27. Epub 2020 Jun 27.

Professor of Dermatology, Beştepe mah. Yaşam Str. Adalet Sok. 13/A, Neorama Plaza, No: 17 Yenimahalle, Ankara, Turkey.

Congenital nevi or acquired nevi are classifications of junctional melanocytic nevi. Junctional melanocytic nevi have round or ovoid shaped macular lesions with brownish colors due to the proliferation of benign nevus cells. Most of the acquired junctional melanocytic nevi (ajmn) are harmless and can be left without treatment. Read More

J Am Acad Dermatol 2020 Jun 24. Epub 2020 Jun 24.

Dermatology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

J Eur Acad Dermatol Venereol 2020 Jun 24. Epub 2020 Jun 24.

Clinic of Neurology with Institute for Translational Neurology, University of Münster, Münster, Germany.

We describe a 33-year-old male patient who developed hypopigmentation around his melanocytic nevi with disappearance of the nevi in August 2018. In June 2016 he had been diagnosed with highly active RRMS and treated with alemtuzumab in September 2016 for the first time. In September 2017 another cycle of alemtuzumab was administered. Read More

J Dtsch Dermatol Ges 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Clin Case Rep 2020 Jun 24;8(6):1007-1009. Epub 2020 Mar 24.

Division of Dermatological Science Department of Dermatology Nihon University School of Medicine Tokyo Japan.

Spitz nevus is an important differential diagnosis of malignant melanoma, especially in young adults. This case provides a significant information about unusual dermoscopic features of adult Spitz nevus, which may reflect changes over the years. Read More

Molecules 2020 Jun 20;25(12). Epub 2020 Jun 20.

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.

A key challenge in melanoma diagnosis is the large number of unnecessary biopsies on benign nevi, which requires significant amounts of time and money. To reduce unnecessary biopsies while still accurately detecting melanoma lesions, we propose using Raman spectroscopy as a non-invasive, fast, and inexpensive method for generating a "second opinion" for lesions being considered for biopsy. We collected in vivo Raman spectral data in the clinical skin screening setting from 52 patients, including 53 pigmented lesions and 7 melanomas. Read More

J Cosmet Dermatol 2020 Jun 23. Epub 2020 Jun 23.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.

Background: Becker's nevus is a common skin disorder. Lasers and light instruments are the major modalities for the treatment of Becker's nevus, but the outcomes were mixed.

Objective: To evaluate the efficacy of the intense pulsed light for Becker's nevus in a large Chinese cohort. Read More

Pathol Oncol Res 2020 Jun 22. Epub 2020 Jun 22.

Department of Medical Oncology, Koc University, Istanbul, Turkey.

The clinical significances of de novo and nevus-associated melanomas are controversial. In this study, we investigated the correlations of these forms of melanomas in respect to their pathological and clinical features and patient outcomes. The data of 660 pathologically confirmed Turkish-Caucasian melanoma patients, whose tumors were either associated with a pre-existing melanocytic nevus or not, were analyzed retrospectively. Read More

J Invest Dermatol 2020 Jul;140(7):1320-1323

Department of Dermatology, Boston University Medical School, Boston, Massachusetts, USA.

The diagnosis of Spitzoid melanocytic lesions remains a formidable challenge in dermatopathology. Numerous ancillary tests have evolved to improve accurate classification of histopathologically ambiguous lesions. A study by Lang et al. Read More

Am J Dermatopathol 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology, Fundación Jimenez-Diaz, Madrid, Spain.

Deep penetrating nevus (DPN) is an intradermal, sometimes compound benign melanocytic lesion, which involves the reticular dermis, occasionally reaching the subcutis, which can raise concern for melanoma both clinically and histologically. Recently, it has been genetically defined by the combination of MAPK activating and β-catenin activating mutations. We sought to investigate genetic alterations in 2 cases of combined nevi of congenital melanocytic and DPN. Read More

J Am Acad Dermatol 2020 Jun 18. Epub 2020 Jun 18.

The Kittner Skin Cancer Screening and Research Institute, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Dermatology Service, Memorial Sloan-Kettering Center, New York, NY.

Reflectance confocal microscopy (RCM) is a high-resolution, non-invasive tool currently FDA-approved for obtaining and interpreting images of the skin and cutaneous neoplasms with the goal of decreasing biopsy of benign lesions. Part II of this continuing medical education series focuses on identifying key criteria for the diagnosis of common skin cancers-melanoma, basal cell carcinoma, and squamous cell carcinoma. We contrast these findings with RCM features of common benign lesions-melanocytic nevi, solar lentigo, seborrheic keratosis, lichen planus-like keratosis, and sebaceous hyperplasia. Read More

Ann Dermatol Venereol 2020 Jun 17. Epub 2020 Jun 17.

Groupe hospitalier Necker-Enfants malades, service d'anatomopathologie, AP-HP, Paris, France.

Introduction: Neonatal and infantile malignant melanoma is rare. It may be difficult to diagnose and often carries a poor prognosis.

Material And Methods: We decided to review the data on congenital, neonatal and infantile malignant melanomas in order to understand their presentation (clinical, histological, molecular), diagnosis, management and outcomes. Read More

Dermatol Ther 2020 Jun 18:e13865. Epub 2020 Jun 18.

Department of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, China.

J Dermatol 2020 Jun 18. Epub 2020 Jun 18.

QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

Melanoma incidence is increasing globally with Australia having the highest incidence in the world. Pregnancy-associated melanoma is recognized in the published work; however, significant knowledge deficiencies exist. We present the case of a 34-year-old woman with dysplastic nevus syndrome who over a 15-year period developed a total of nine melanomas, with eight clustered around an 18-month peri- to post-partum period. Read More

Acta Derm Venereol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark. E-mail:

Halo naevi are considered benign. They occur in children and adolescents. Eruptive multiple halo naevi are infrequently seen in adults. Read More

Actas Dermosifiliogr 2020 Jun 15. Epub 2020 Jun 15.

Jefe de Servicio, Servicio de Dermatología, Hospital Alemán, Buenos Aires, Argentina.

Arch Soc Esp Oftalmol 2020 Jun 15. Epub 2020 Jun 15.

Sección de Cornea, Servicio de Oftalmología, Hospital Universitario Fundación Jiménez Díaz, Madrid, España.

PeerJ 2020 3;8:e9273. Epub 2020 Jun 3.

Department of Dermatology, The First Hospital of China Medical University and Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, Liaoning, China.

Background: Melanoma is a highly invasive malignant skin tumor. While melanoma may share some similarities with that of melanocytic nevi, there also exist a number of distinct differences between these conditions. An analysis of these differences may provide a means to more effectively evaluate the etiology and pathogenesis of melanoma. Read More

Int J Surg Case Rep 2020 Jun 1;72:202-206. Epub 2020 Jun 1.

Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Sabah, Malaysia. Electronic address:

Introduction: Blue Rubber Bleb Nevus Syndrome (BRBNS) also known as Bean's Syndrome is an atypical type of vascular malformation. To date, around 200 cases have been reported world-wide. In view of its low incidence rate, clinicians might misdiagnose and under treat. Read More

Dermatology 2020 Jun 15:1-9. Epub 2020 Jun 15.

Center of Dermatooncology, Department of Dermatology, University Hospital Tübingen, Eberhard-Karls-University, Tübingen, Germany,

Background: Caucasians with red hair and fair skin have a remarkably increased risk of malignant melanoma compared to non-redhead Caucasians.

Objectives: With the aim of a reliable melanoma diagnosis in redheads, the application of dermatofluoroscopy was analyzed in 16 patients with red hair. Most of them had been included in a clinical dermatofluoroscopy study for patients with the suspicion of melanoma. Read More

J Am Acad Dermatol 2020 Jun 10. Epub 2020 Jun 10.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

Background: Nevus phenotype is a marker of melanoma risk. In-vivo prediction of microscopic pattern is needed to more precisely classify nevi.

Objective: To identify dermoscopic and clinical predictors of microscopic patterns of typical nevi. Read More

Lasers Med Sci 2020 Jun 13. Epub 2020 Jun 13.

Department of Facial Plastic and Reconstructive Surgery, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

The aim of this study was to evaluate the efficacy and safety of 1064 nm neodymium-doped yttrium-aluminum-garnet laser treatment of melanocytic nevus of the external auditory canal. Retrospective chart review of 15 patients operated by 1064 nm Nd:YAG laser in single center. Data from charts and video documentation were collected and analyzed. Read More

Dermatol Ther 2020 Jun 12:e13821. Epub 2020 Jun 12.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.

An atypical cellular blue nevus, a benign mass, may sometimes transform into a malignant melanoma. Here, we report a rare case of melanoma arising in a large congenital vulvar blue nevus. A 28-year-old Chinese woman presented to our hospital with a chief complaint of a vulvar mass that had persisted for eight years. Read More

Dermatol Ther 2020 Jun 12:e13804. Epub 2020 Jun 12.

Department of Dermatology and Venereology, the Republic of Turkey, Health Sciences University Erzurum Regional Training and Research Hospital, Turkey.

We aim to evaluate the change in the diagnostic spectrum in dermatology outpatient applications compared to before COVID-19. All patients were enrolled from the Department of Dermatology between February 12 and May 8, 2020, the duration of 4 weeks before COVID-19 and eight weeks after were analyzed in 3 parts consisting of 4 weeks. Data obtained from the database such as age, gender, diagnoses were anonymized. Read More

J Cutan Pathol 2020 Jun 11. Epub 2020 Jun 11.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Deep penetrating nevi (DPN) are dermal-based, heavily pigmented melanocytic proliferations primarily resulting from mutations in B-catenin and BRAF or, less commonly, NRAS. DPNs are considered to be intermediate grade tumors which are stable with low risk of malignant transformation. The precise risk for transformation is unknown. Read More

Indian J Surg Oncol 2020 Jun 29;11(2):306-307. Epub 2020 Jan 29.

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kerala India.

Congenital giant nevi are melanotic proliferations present at birth which often grow to 20 cm or more when adulthood is attained. These patients stand the risk of developing melanomas including dermal melanomas in more than 2/3rd of patients. The risk of melanoma development is highest in childhood although it can occasionally occur in adults. Read More

BMC Gastroenterol 2020 Jun 10;20(1):182. Epub 2020 Jun 10.

Department of Gastroenterology, Yinzhou Hospital affiliated to Medical School of Ningbo University, 251 Baizhang Rd. Ningbo, Zhejiang, 315040, China.

Background: Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital disease characterized by multifocal venous malformations. It remains a considerable challenge in treating the gastrointestinal (GI) venous malformations due to multiple lesions throughout the GI tract, and the likelihood of recurrence. We report a case study of BRBNS in the GI tract, in which GI venous malformations and related GI bleeding were successfully treated with a combination of multiple endoscopic procedures. Read More

Am J Surg Pathol 2020 Jun 9. Epub 2020 Jun 9.

Departments of Pathology.

Deep penetrating nevi (DPNs) are intermediate grade lesions which have the capacity to recur, metastasize, or progress to melanoma. Differentiating DPN from other melanocytic lesions including blue and cellular blue nevi can be diagnostically challenging, and markers to distinguish these entities can be useful. Mutations of the β-catenin and mitogen-activated protein kinase pathways have recently been elucidated as distinctive of DPN. Read More

J Cutan Pathol 2020 Jun 9. Epub 2020 Jun 9.

Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Buschke-Ollendorff syndrome (BOS; OMIM 166700) is a rare autosomal dominant disorder characterized by the existence of connective tissue nevus and/or osteopoikilosis. The skin lesions usually present as firm, yellow or flesh-colored papules and nodules, which may coalesce into plaques and increase in size and number over time. We present a case of a 26-year-old male with multiple subcutaneous nodules on the waist and thigh for more than 20 years. Read More

Case Rep Dermatol 2020 May-Aug;12(2):98-106. Epub 2020 May 15.

Department of Medicine and Medical Specialties, University of Alcalá, Madrid, Spain.

Pigmented Bowen's disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. Read More

Eur J Ophthalmol 2020 Jun 9:1120672120934390. Epub 2020 Jun 9.

Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.

Purpose: To report a case of quiescent choroidal neovascularization (CNV) associated with choroidal nevus using optical coherence tomography angiography (OCTA) during 5 years follow-up.

Methods: Observational case report.

Results: A 53-year old woman was referred our department with diagnosis of choroidal nevus. Read More

Int J Retina Vitreous 2020 2;6:19. Epub 2020 Jun 2.

Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, 14049-900 Brazil.

Background: To report an association between choroidal nevus and polypoidal choroidal vasculopathy (PCV) in three patients.

Case Presentation: We have encountered 3 isolated patients in our center presenting with subretinal exudation and a choroidal nevus that were thoroughly evaluated by slit lamp biomicroscopy, fundus photos, Fluorescein angiography (FA), indocyanine green angiography (ICG), B-scan ultrasound, and optical coherence tomography (SD-OCT-Heidelberg). The classic features of choroidal neovascularization seen on PVC were present in all 3 patients, all of whom had a substantial response to intravitreous antiangiogenic agent. Read More

Clin Dermatol 2020 Mar - Apr;38(2):257-261. Epub 2019 Jun 21.

Spiders have long been admired for the beauty of their webs. They are celebrated in popular culture as well as in medical eponyms. This contribution provides the historical background for three spider-related eponyms: nevus araneus (spider angioma), arachnodactyly, and the arachnoid mater. Read More

Folia Biol (Praha) 2020 ;66(1):1-6

Biocev, First Faculty of Medicine, Charles University, Vestec, Czech Republic.

Hereditary haemorrhagic telangiectasia (HHT) exhibits considerable phenotypic heterogeneity. Therefore, precise mutation screening and evaluation of patient risk must be determined in every HHT family. We present an HHT-2 case with an initial life-threatening bleeding episode that led to identification of a relatively large HHT family. Read More

Eur J Pediatr Surg 2020 Jun 8. Epub 2020 Jun 8.

Division of Plastic, Reconstructive and Aesthetic Surgery, Università degli Studi di Napoli Federico II Scuola di Medicina e Chirurgia, Federico II University, Naples, Campania, Italy.

Introduction:  Skin tags are benign lesions, that often represent only an aesthetic problem; if subjected to trauma, they can occasionally bleed with possible infection and pain. When they occur in the preauricular region, attention should be paid to the diagnosis and approach; in fact, controversy exists in the differential diagnosis between hair follicle nevi, accessory tragus, and skin tag. Misdiagnosis and failure of treatment can lead to serious consequences, such as chondritis. Read More

Acta Derm Venereol 2020 Jun 8. Epub 2020 Jun 8.

Department of Dermatology, Venerology and Allergology, University Medical Center, Ruprecht-Karls-University, Im Neuenheimer Feld 440, DE-69120 Heidelberg, Germany. E-mail:

JAAD Case Rep 2020 Jun 25;6(6):563-566. Epub 2020 Apr 25.

Department of Dermatology, Michigan Medicine, Ann Arbor, Michigan.

Front Oncol 2020 20;10:837. Epub 2020 May 20.

Division of Health Care Sciences, Center for Clinical Research and Management Education, Dresden International University, Dresden, Germany.

Deep penetrating nevi (DPN) are rare melanocytic nevi, which can exhibit atypical histological features hampering the differentiation from malignant melanoma. DPN are considered benign melanocytic lesions, but rare spread to lymph nodes and unfavorable clinical outcomes associated with borderline/atypical DPN (B-DPN) has been reported. Since no guidelines are available for DPN and B-DPN, we aimed to review the literature on DPN and B-DPN to assess the management and prognosis. Read More

Exp Ther Med 2020 Jul 20;20(1):78-86. Epub 2020 Mar 20.

Department of Dermatology, 'Grigore T. Popa' University of Medicine and Pharmacy, Faculty of Medicine, 700115 Iasi, Romania.

Early detection of skin cancer is essential in order to obtain an improved prognosis. Clinicians need more objective and non-invasive examination methods to support their decision whether to biopsy or not tumoral lesions. These may include several imaging techniques such as dermoscopy, videodermoscopy, also known as sequential digital dermoscopy (SDD), computer-aided diagnosis (CAD), total body photography, imaging and high-frequency ultrasonography (HFUS), reflectance confocal microscopy, multiphoton tomography, electrical impedance spectroscopy, Raman spectroscopy, stepwise two-photon-laser spectroscopy and quantitative dynamic infrared. Read More

Calcif Tissue Int 2020 Jun 5. Epub 2020 Jun 5.

Department of Medicine Section of Endocrinology, Yale School of Medicine, PO Box 802080, New Haven, CT, 06520, USA.

FGF23 is a hormone produced by osteocytes in response to an elevation in the concentration of extracellular phosphate. Excess production of FGF23 by bone cells, or rarely by tumors, is the hormonal basis for several musculoskeletal syndromes characterized by hypophosphatemia due to renal phosphate wasting. FGF23-dependent chronic hypophosphatemia causes rickets and osteomalacia, as well as other skeletal complications. Read More

Cancers (Basel) 2020 Jun 3;12(6). Epub 2020 Jun 3.

Department of Cell Biology and Histology, Faculty of Medicine and Nursing, UPV/EHU, 48940 Leioa, Spain.

Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of key signaling pathways involved in the aggressive tumor phenotype and shows decreased expression in several types of cancers. However, little is known about RKIP in melanoma or regarding its function in normal cells. We examined the role of RKIP in both primary melanocytes and malignant melanoma cells and evaluated its diagnostic and prognostic value. Read More

Dermatol Ther 2020 Jun 4:e13763. Epub 2020 Jun 4.

Department of Dermatology, University of Parma, via Gramsci 14, Parma, Italy.

Blue nevus, in all its clinical variants, rarely affects the nail bed. This leads to difficulty in the diagnosis of blue nevi within the nail bed as well as to challenges with regards to its treatment and follow up management, not solely attributed to the intrinsic difficulty of the anatomical site. We present the first case in literature of an Acquired Cellular Blue Nevus entirely confined within the nail bed, in a female caucasian patient. Read More

Int J Dermatol 2020 Jun 4. Epub 2020 Jun 4.

EsteDerm Private Dermatology Unit, Tychy, Poland.

Background: Dermatofibroma (DF) is a common benign skin lesion in a majority of cases located on the legs or upper limbs. The etiology of DF is still unclear.

Objectives: Reflectance confocal microscopy features of DF were described. Read More