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Pathol Res Pract 2022 May 14;235:153942. Epub 2022 May 14.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna 40100, Italy; Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna 40100, Italy.

Background: dysplastic nevi (DN) share some clinical and histological features with melanoma and have been considered intermediate lesions toward malignant transformation. However, scientific evidence of DN representing melanoma precursors is still incomplete, and many observations pointed toward their being a distinct biological entity. The current definition of DN is also confusing and the practical consequence of this uncertainty is the excessive excision of DN with severe atypia. Read More

J Cosmet Dermatol 2022 May 20. Epub 2022 May 20.

Department of Brun and Plastic Surgery of Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China.

Background: Congenital melanocytic nevi (CMN), benign pigmented birthmarks caused by the mutation of melanocytic cells during embryofetal development, can cause aesthetic problem when it located on the face. Surgical managements of facial CMN are required by both pediatric patients and their parents. Surgical management, including excision or staged excision, skin grafting, dermabrasion, tissue expansion or multiple re-expansion combined with flaps transplantation, have been reported previously. Read More

Pigment Cell Melanoma Res 2022 May 19. Epub 2022 May 19.

Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

We recently reported a RAF rearrangement without NRAS or BRAF mutations in lesions from Giant Congenital Melanocytic Nevi (CMN). The new gene fusion involves the 5' end of the promoter-containing N terminus of the SOX5 gene fused to exons 7-16 of the 3' end of RAF1 gene leading to a SOX5-RAF1 fusion transcript which loss the auto-inhibitory CR1 domain but retains the complete in-frame coding sequence for the C-Terminal kinase domain of the RAF1. Stable expression of SOX5-RAF1 fusion induced growth factor-independent cell growth in murine hematopoietic Ba/F3 cells and melan-a immortalized melanocytes. Read More

Rev Assoc Med Bras (1992) 2022 May;68(5):680-684

General Hospital Novi Pazar, Department of Surgery - Novi Pazar, Serbia.

Objective: The aim of this study was to evaluate the expression of endoglin and its correlation with histopathological and clinical findings in conjunctival nevi.

Methods: The study included archival formalin-fixed, paraffin-embedded tissue sections of 44 patients with conjunctival nevi. Immunohistochemical staining for CD105 had been performed with monoclonal mouse antihuman CD105 antibodies. Read More

J Oral Maxillofac Res 2022 Jan-Mar;13(1):e5. Epub 2022 Mar 31.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of AthensGreece.

Background: Oral melanocytic nevi are relatively rare in comparison to their cutaneous counterparts. The aim of this manuscript is to present a case of acquired compound oral melanocytic nevi on the hard palatal mucosa of a child.

Methods: A 5-year-old female girl was referred for evaluation of a pigmented lesion on the hard palate. Read More

Front Med (Lausanne) 2022 29;9:863468. Epub 2022 Apr 29.

Unit of Dermatology and Cosmetology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Hospital, Milan, Italy.

Breast cancer-associated genes 1 and 2 (BRCA1 and BRCA2) are tumor suppressor genes encoding a large protein that is involved in many essential biological processes. BRCA mutated patients show an increased risk to develop several malignancies, including cutaneous malignancies, although inconsistently across multiple studies. We carried out an observational study on the main dermatological and dermoscopic aspects in a population of patients with BRCA 1/2 mutations, to identify the main clinical and dermoscopical features in this class of patients. Read More

J Dermatol 2022 May 13. Epub 2022 May 13.

Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Phacomatosis pigmentokeratotica (PPK) is a rare epidermal nevus (EN) syndrome, featured by co-occurrence of speckled lentiginous nevus (SLN) and nevus sebaceous (NS). The underlying mechanism has not been clarified. Pathogenic mutations in HRAS, KRAS and BRAF gene are recently recognized as the genetic cause of PPK. Read More

J Clin Med 2022 Apr 29;11(9). Epub 2022 Apr 29.

Department of Maxillofacial Surgery, Medical University of Lodz, 113 S. Zeromski Street, 90-549 Lodz, Poland.

The differential diagnosis of benign nevi (BN), dysplastic nevi (DN), and melanomas (MM) represents a considerable clinical problem. These lesions are similar in clinical examination but have different prognoses and therapeutic management techniques. A texture analysis (TA) is a mathematical and statistical analysis of pixel patterns of a digital image. Read More

Cells 2022 Apr 28;11(9). Epub 2022 Apr 28.

Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.

Detection and quantification of senescent cells remain difficult due to variable phenotypes and the absence of highly specific and reliable biomarkers. It is therefore widely accepted to use a combination of multiple markers and cellular characteristics to define senescent cells in vitro. The exact choice of these markers is a subject of ongoing discussion and usually depends on objective reasons such as cell type and treatment conditions, as well as subjective considerations including feasibility and personal experience. Read More

Int J Mol Sci 2022 Apr 26;23(9). Epub 2022 Apr 26.

Clinica Dermatologica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, 60126 Ancona, Italy.

The tetraspanin CD9 is considered a metastasis suppressor in many cancers, however its role is highly debated. Currently, little is known about CD9 prognostic value in cutaneous melanoma. Our aim was to analyse CD9 expression in melanocytic nevi and primary cutaneous melanomas through immunohistochemistry and immunofluorescence approaches to determine its correlation with invasiveness and metastatic potential. Read More

Cell 2022 May 9. Epub 2022 May 9.

Department of Translational Molecular Medicine, Saint John's Cancer Institute Providence Health and System, Santa Monica, CA 90404.

Giant congenital melanocytic nevi are NRAS-driven proliferations that may cover up to 80% of the body surface. Their most dangerous consequence is progression to melanoma. This risk often triggers preemptive extensive surgical excisions in childhood, producing severe lifelong challenges. Read More

Acta Biomed 2022 May 11;93(2):e2021464. Epub 2022 May 11.

Department of Microbiology, National Pirogov Memorial Medical University, Pirogov, 56, Vinnytsia, Ukraine,.

To date, there are many methods and ways to remove pigmented skin tumors, which have their own indications and contraindications for use, early or late complications.The aim of the study was to determine the level of CCL2 / MCP-1 in the serum of patients with melanocyte skin nevi in the postoperative period with different methods of their removal.Materials and methods of research. Read More

BMJ Case Rep 2022 05 11;15(5). Epub 2022 May 11.

Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.

Int J Clin Exp Pathol 2022 15;15(4):201-205. Epub 2022 Apr 15.

Department of Dermatology, Wayne State University MI, USA.

Nevoid and myxoid melanoma are rare variants of melanoma; association of the two is a unique finding. Nevoid melanoma is characterized by morphologic resemblance to a nevus, whereas myxoid melanoma demonstrates a basophilic mucinous matrix. We present an atypical case of a melanoma progressing from a nevoid melanocytoma with myxoid changes. Read More

Pigment Cell Melanoma Res 2022 May 8. Epub 2022 May 8.

Department of Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

Background: Epidermal melanocytes sense solar light via the opsin-coupled signaling pathway which is involved in a range of biological functions, including regulating pigmentation, proliferation, apoptosis, and tumorigenesis. However, it remains unclear whether there are genetic variants within these opsins that affect opsin protein structure and function, and further melanocyte biological behaviors.

Methods: Here, we examined single nucleotide variants (SNVs) of five opsin (RGR, OPN1SW, OPN2, OPN4, and OPN5) genes in MM (malignant melanoma) (n=76) and MN (melanocytic nevi) (n=157), using next-generation sequencing. Read More

Actas Dermosifiliogr 2022 03 9;113(3):T301-T302. Epub 2022 Feb 9.

Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Actas Dermosifiliogr 2022 03 9;113(3):319-321. Epub 2022 Feb 9.

Departamento de Dermatología, Hospital Humberto Notti, Guaymallén, Mendoza, Argentina.

Actas Dermosifiliogr 2022 03 14;113(3):301-302. Epub 2021 Sep 14.

Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Actas Dermosifiliogr 2022 May 5. Epub 2022 May 5.

Servicio de Dermatología Hospital General Universitario Gregorio Marañón, Madrid, España.

Dedicated dermoscopy units assess individuals at high risk for melanoma. Understanding the reasons for referral to these units and the epidemiological profile of referred patients can help optimize health care resources and determine who benefits most from dermoscopic evaluation. We analyzed reasons for referral and epidemiological characteristics of 413 patients with at least 1 high-risk factor for melanoma seen at a dedicated dermoscopy unit over a period of 10 years. Read More

Dermatology 2022 May 4:1-9. Epub 2022 May 4.

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Introduction: Examination of subungual pigmented lesions is sometimes a diagnostic challenge for clinicians.

Objectives: The study was aimed to investigate characteristic patterns in optical coherence tomography (OCT) of subungual hematomas and determine distinctive features that can differentiate them from subungual melanocytic lesions.

Methods: VivoSight® (Michelson Diagnostics, Maidstone, UK) was used to examine 71 subungual hematomas and 11 subungual melanocytic lesions in 69 patients (18 female and 51 male patients). Read More

Am J Dermatopathol 2022 Apr 27. Epub 2022 Apr 27.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Abstract: Spitzoid melanocytic neoplasms are a diagnostically challenging class of lesions in dermatopathology. Recently, molecular assays and immunohistochemical markers have been explored as ancillary methods to assist in the diagnostic workup. Specifically, preferentially expressed antigen in melanoma (PRAME) immunohistochemistry is a nuclear stain commonly positive in melanomas, but not in nevi. Read More

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Stomatology, Dental School, University of Sao Paulo, Sao Paulo, Brazil; and.

Abstract: Oral pigmentations are a heterogeneous group and can be the result of physiological activity of oral mucosal melanocytes, secondary to exogenous causes, associated with systemic or local diseases, or due to proliferative activity of melanocytes. Their diagnosis is critical because these lesions can be markers of internal diseases or, in the case of melanocytic proliferative processes, they may represent a malignant neoplasm. In the past decade, the use of reflectance confocal microscopy, a noninvasive imaging tool, has aided the analysis of such lesions, but the establishment of firm criteria in their evaluation is still lacking. Read More

Am J Dermatopathol 2022 Apr 27. Epub 2022 Apr 27.

Department of Pathology, Advent Health, Orlando, FL.

Abstract: In dermal melanocytoses such as blue nevus or nevus of Ota, an ultrastructural study has demonstrated an intimate relationship between the dendritic melanocytes and the dermal elastic fibers with elongated cytoplasmic processes of the melanocytes aligning lengthwise along the axis of the elastic fibers in longitudinal sections and encircling the elastic fibers in cross-sections. Such a close arrangement has not been reported in common melanocytic nevi. The current case described a similar arrangement between the melanocytes and the dermal elastic fibers in a usual intradermal melanocytic nevus. Read More

Photodiagnosis Photodyn Ther 2022 Apr 28:102890. Epub 2022 Apr 28.

Department of Dermatology, Shanghai Pudong New Area People's Hospital, Shanghai, China, 201299. Electronic address:

A case of phakomatosis pigmentovascularis (PPV) type III a with a zosteriform distribution of nevus spilus as the main manifestation was reported. A 41-year-old man was born with a zosteriform distribution of pigmented rash on the left half-body, namely upper limb, shoulder and back. Physical examination revealed light brown pigments in a giant zosteriform distribution on the extensor side of the left upper limb and the left shoulder and back, with scattered brown spots and patches of variant sizes on the surface, which are consistent with the appearance of nevus spilus (NS). Read More

J Cutan Pathol 2022 Apr 30. Epub 2022 Apr 30.

Kaiser Permanente Los Angeles Medical Center, 4867 W. Sunset Boulevard, Los Angeles, CA, USA.

Background: Spitzoid melanocytic neoplasms are well known to be diagnostically challenging. Immunohistochemistry and molecular approaches have been used as ancillary diagnostic tests. Herein we investigate the use of PRAME immunohistochemistry (IHC) for the assessment of spitzoid melanocytic neoplasms. Read More

J Am Acad Dermatol 2022 Apr 26. Epub 2022 Apr 26.

Department of Cutaneous Oncology, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.

Background: Morphology and biology of nevi with peripheral globules are well known, while that of melanomas with peripheral globules remain unclear.

Objective: Comparing the dermoscopic characteristics of nevi and melanomas with peripheral globules.

Methods: A total of 401 melanocytic lesions with peripheral globules were included in this retrospective study. Read More

Orbit 2022 Apr 28:1-8. Epub 2022 Apr 28.

Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Purpose: To describe two patients with blue nevi of the palpebral conjunctiva and to review the existing literature on common and cellular blue nevi of the conjunctiva.

Methods: Report of two cases and literature review.

Results: We present two cases of blue nevi in the palpebral conjunctiva: an atypical cellular blue nevus of the left upper eyelid and a common blue nevus around the lacrimal punctum of the left lower eyelid. Read More

Am J Dermatopathol 2022 Apr 11. Epub 2022 Apr 11.

Departments of Pathology, and.

Abstract: Conjunctival melanocytic proliferations are diagnostically challenging, often complicated by small specimen size, and are separated into 3 broad categories. The first group includes benign nevi and primary acquired melanosis (PAM) without atypia. The second group includes junctional melanocytic proliferations with a risk of progression to invasive melanoma (PAM with atypia). Read More

Iran J Pathol 2022 8;17(2):234-237. Epub 2022 Mar 8.

Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Nevus comedonicus (NC) is a rare developmental anomaly of the folliculosebaceous apparatus, which appears as numerous dilated papules containing firm, darkly pigmented, horny plugs. It appears shortly after birth and mostly before the age of 10; however, late-onset cases have been reported. There is no gender or racial predilection. Read More

Int J Mol Sci 2022 Apr 11;23(8). Epub 2022 Apr 11.

Pathological Anatomy Unit, University Hospital of Padua, 35121 Padua, Italy.

Spitz neoplasms are a heterogeneous group of melanocytic proliferations with a great variability in the histological characteristics and in the biological behavior. Thanks to recent discoveries, the morpho-molecular landscape of Spitz lineage is becoming clearer, with the identification of subtypes with recurrent features thus providing the basis for a more solid and precise tumor classification. Indeed, specific mutually exclusive driver molecular events, namely or mutations, copy number gains of 11p, and fusions involving and genes, correlate with distinctive histological features. Read More