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    A Case of Adenocarcinoma of the Retinal Pigment Epithelium: An Immunohistochemical and Electron Microscopic Study.
    Ocul Oncol Pathol 2017 Dec 19;4(1):38-43. Epub 2017 Jul 19.
    Department of Ophthalmology, Kansai Medical University, Osaka, Japan.
    Purpose: Retinal pigment epithelium (RPE) adenocarcinoma is a very rare malignant intraocular tumor. Herein we describe the histopathological features of RPE adenocarcinoma.

    Case: A 36-year-old male was referred to our clinic because of floaters in his left eye. Read More

    Histological features and outcome of inverted type-A melanocytic nevi.
    J Cutan Pathol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Dermatology, Brigham and Women's Hospital, MA.
    The presence of enlarged epithelioid/spindled nests located deep in the reticular dermis of a biphasic melanocytic neoplasm can mimic melanoma arising in a preexisting nevus, causing over-interpretation of malignancy. We aimed to define the clinicopathologic significance of epithelioid/spindled nests in melanocytic nevi. Retrospectively using clinical and histologic information, we characterized 121 patients with a single lesion showing epithelioid/spindled melanocytes in the reticular dermis or subcutaneous fat, surrounded by melanophages, sometimes blending in with the adnexa. Read More

    [Phakomatosis pigmentovascularis cesioflammea: a case report].
    Arch Argent Pediatr 2018 Feb;116(1):e121-e124
    Servicio de Dermatología, Hospital Nacional de Pediatría "Prof. Dr. J. P. Garrahan", Ciudad Autónoma de Buenos Aires.
    Phakomatosis pigmentovascularis (PPV) is a syndrome characterized by the association of a vascular nevus with a congenital pigmented lesion (epidermal nevus, nevus spilus, and dermal melanocytosis). There are different types of PPV according to the pigmentary nevus associated with the vascular malformation. Patients may present only the cutaneous condition or have systemic manifestations, among them, trauma, neurological and ophthalmological disorders. Read More

    BRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi.
    Invest Ophthalmol Vis Sci 2018 Jan;59(1):117-121
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, United States.
    Purpose: To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi.

    Methods: Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. Read More

    Epigenetic Reprogramming of Pericentromeric Satellite DNA in Premalignant and Malignant Lesions.
    Mol Cancer Res 2018 Jan 12. Epub 2018 Jan 12.
    Department of Cancer and Inflammation Research, University of Southern Denmark
    Repression of repetitive DNA is important for maintaining genomic stability, but is often perturbed in cancer. For instance, the megabase satellite domain at chromosome 1q12 is a common site of genetic rearrangements, such as translocations and deletions. Polycomb-group (PcG) proteins can be observed as large subnuclear domains called polycomb bodies, the composition and cellular function of which has remained elusive. Read More

    Giant congenital melanocytic nevus with vascular malformation and epidermal cysts associated with a somatic activating mutation in BRAF.
    Pigment Cell Melanoma Res 2018 Jan 5. Epub 2018 Jan 5.
    Dermatological group practice, Lübeck, Germany.
    Giant congenital melanocytic nevi may be symptomatically isolated, or syndromic. Associations with capillary malformations are exceptional, and development of epidermal cysts has not been described. A 71-year old patient with a giant congenital melanocytic nevus of the lower back, buttocks and thighs was asymptomatic except for unexpected hemorrhage during partial surgical excision years before. Read More

    Speckled lentiginous nevus: understanding the process of development and regression.
    Br J Dermatol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Dermatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
    Speckled lentiginous nevus (SLN) is characterized by a brownish macule studded with blackish, multiple melanocytic nevi, although the cutaneous manifestations may vary by cases, and change by age. Therefore, there has been disagreement as to whether SLN is a congenital or acquired disease 1, 2). In rare cases of SLN, halo phenomenon may occur around the pre-existing lesion, associated with the coexistence of distant vitiligo 3). Read More

    Acral pigmented Spitz nevus in a child with transepidermal migration of melanocytes: Dermoscopic and reflectance confocal microscopic features.
    Pediatr Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, School of Medicine & Health Sciences, George Washington University, Washington, DC, USA.
    Acral pigmented Spitz nevi are seldom reported in the literature. We report a new case on the palm of a 4-year-old girl that demonstrated correlation between features observed on dermoscopy and reflectance confocal microscopy (RCM). Histopathology revealed a benign intraepidermal Spitz nevus with transepidermal elimination of melanocytes that showed on RCM as focal atypical bright cells concerning for malignancy. Read More

    Kissing nevus of the penis: a case report and dermatoscopic findings.
    An Bras Dermatol 2017 ;92(5 Suppl 1):95-97
    Department of Dermatology, Faculdade de Medicina da Universidade do Oeste Paulista (Unoeste) - Presidente Prudente - SP, Brazil.
    Divided nevus, also known as kissing nevus, is a rare variant of congenital melanocytic nevi in which there are two adjacent nevi in areas of the body that undergo embryonic cleavage. The original description of this type of lesion was on the eyelid. The location on the penis is even rarer, with only 17 case reports in the literature so far, and only one of them described the dermoscopic findings. Read More

    Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review.
    Rom J Morphol Embryol 2017 ;58(3):739-747
    Department of Neurosurgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;
    Aim: The conjunctival nevus affecting children and adolescents is a rare condition and the literature showed only few reports on this issue. The aim of this article is to determine the histopathological features for the correct diagnosis of an inflammatory juvenile compound nevus of the conjunctiva (IJCNC) in order to make the difference between this tumor and other lesions, like conjunctival melanoma or lymphoma, very similar from a gross point of view. This article is a clinical pathological study of two cases of IJCNC with particular histopathological characteristics, who were admitted at the 2nd Ophthalmology Clinic, "Prof. Read More

    The variegated histopathological features of atypical lentiginous melanocytic nevi (ALMNs): a single institution experience.
    G Ital Dermatol Venereol 2017 Dec 15. Epub 2017 Dec 15.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Background: Atypical lentiginous melanocytic nevi (ALMNs) are atypical pigmented lesions with histopathological features similar to those of dysplastic nevi, with a lentiginous pattern. Variable histopathological features of ALMNs were observed in our practice.

    Methods: We described the histopathological features of ALMNs diagnosed in the period 2009- 2015. Read More

    SLURP-1 is mutated in Mal de Meleda, a potential molecular signature for melanoma and a putative squamous lineage tumor suppressor gene.
    Int J Dermatol 2018 Feb 12;57(2):162-170. Epub 2017 Dec 12.
    Department of Dermatology, American University of Beirut, Beirut, Lebanon.
    Background: Mal de Meleda (MDM) is a rare inherited autosomal recessive genodermatosis characterized by palmoplantar keratoderma (PPK) with transgrediens and caused by mutations in the SLURP1 gene. Uncommonly, cutaneous tumors have been found at PPK sites in MDM patients.

    Objective: To study a Middle Eastern family with MDM with both PPK and skin tumors. Read More

    Quantitative assessment of neuropilin-2 as a simple and sensitive diagnostic assay for spitzoid melanocytic lesions.
    Melanoma Res 2018 Feb;28(1):71-75
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
    There is a significant need for the development of diagnostic tools that can precisely distinguish Spitz nevi and spitzoid melanomas. Here, we report the development of a PCR-based quantitative diagnostic assay for spitzoid melanocytic lesions utilizing the expression ratio of neuropilin-2 and melan-A genes in primary tumor specimens. We find that the expression ratio of neuropilin-2/melan-A is significantly increased in spitzoid melanomas compared with Spitz nevi. Read More

    Genomic analysis of a case of agminated Spitz nevi and congenital-pattern nevi arising in extensive nevus spilus.
    J Cutan Pathol 2018 Feb 17;45(2):180-183. Epub 2017 Dec 17.
    Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida.
    Nevus spilus is a melanocytic neoplasm characterized by a tan macular background punctuated by multiple hyperpigmented macules or papules that represent various types of nevi. These include junctional and compound nevi, Spitz nevi, and rarely blue nevi. We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital-pattern compound nevi. Read More

    Use of OCT Angiography in Choroidal Melanocytic Tumors.
    J Ophthalmol 2017 19;2017:1573154. Epub 2017 Oct 19.
    Ophthalmology Department, Hospital La Paz, Madrid, Spain.
    Objective: To describe OCTA findings in choroidal melanocytic tumors, especially the microcirculation patterns, and to try to correlate with the histopathological studies.

    Methods: Cross-sectional, comparative, observational study. 70 cases, including 55 choroidal nevi and 15 choroidal melanomas. Read More

    Genetic Alterations in Primary Acral Melanoma and Acral Melanocytic Nevus in Korea: Common Mutated Genes Show Distinct Cytomorphological Features.
    J Invest Dermatol 2017 Nov 27. Epub 2017 Nov 27.
    Departments of Dermatology, Chonnam National University Medical School. Electronic address:
    Acral melanoma occurring on the palms, soles, and nails is the most common subtype of cutaneous melanoma in Asians. Genetic alterations in acral melanoma and acral melanocytic nevus are not well known. We performed next-generation sequencing and evaluated the correlations between genetic information and the clinicopathologic characteristicsfrom 85 Korean patients with acral melanocytic neoplasms. Read More

    Pigmented Kamino bodies: a little-known histological finding. Prevalence in 19 cases of Reed nevus.
    An Bras Dermatol 2017 May-Jun;92(3):379-382
    Laboratory of Medical Investigation in Mycologia, Faculdade de Medicina, Universidade de São Paulo (LIM 53, FMUSP), São Paulo, SP, Brazil.
    The present study aimed to determine the prevalence of Kamino bodies in Reed nevus, since most studies to date show conflicting data on this issue. This was a retrospective observational study, in which the histopathology of 19 Reed nevus lesions were reviewed. The slides were stained by hematoxylin and eosin and periodic acid-Schiff, with a special focus placed on the identification of Kamino bodies. Read More

    Histopathological diagnosis of small melanocytic lesions suspicious for malignant melanoma.
    An Bras Dermatol 2017 May-Jun;92(3):375-378
    Department of Pathology - School of Medicine at Universidade Federal do Rio de Janeiro (UFRJ) - Rio de Janeiro (RJ), Brazil.
    The concern about malignant skin neoplasms leads to the excision of smaller lesions. This study on small melanocytic lesions aims to evaluate the range of possible histopathological diagnoses, describe histopathological aspects, and assess the usefulness of serial histological sections. We performed a cross-sectional descriptive histopathological study examining 76 pigmented skin lesions up to 6 mm in diameter. Read More

    Dermoscopic patterns of melanocytic nevi in children and adolescents: a cross-sectional study.
    An Bras Dermatol 2017 May-Jun;92(3):340-344
    Dermatology Outpatient Clinic of the Universidade Federal de São Paulo (EPM-UNIFESP) - São Paulo (SP), Brazil.
    Background: Childhood is a dynamic period regarding nevogenesis. Dermoscopy is a noninvasive technique, recommended for the evaluation of pigmented cutaneous lesions.

    Objectives: The purpose of this study was to describe the structures and dermoscopic patterns of melanocytic nevi observed in children and adolescents. Read More

    Non-melanoma Hutchinson's sign: A reappraisal of this important, remarkable melanoma simulant.
    J Eur Acad Dermatol Venereol 2017 Nov 24. Epub 2017 Nov 24.
    Dermatology, Centre Hospitalier Lyon Sud, 69495, Pierre Benite, Cedex, France.
    Background: More than 20 years ago our reappraisal of the Hutchinson Sign (HS) gave birth to the concept of the Pseudo-Hutchinson sign.

    Objectives: We have found it interesting to emphasize some important histologic points and to expand the list of the numerous HS simulants.

    Methods: We have examined the cutaneous samples taken from the pigmented skin of patients in association with nail matrix biopsy. Read More

    Evaluating melanocytic lesions with single nucleotide polymorphism (SNP) chromosomal microarray.
    Exp Mol Pathol 2017 12 21;103(3):279-287. Epub 2017 Nov 21.
    Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States. Electronic address:
    Histopathology is the gold standard for diagnosing melanocytic lesions; however, distinguishing benign versus malignant is not always clear histologically. Single nucleotide polymorphism (SNP) microarray analysis may help in making a definitive diagnosis. Here, we share our experience with the Oncoscan FFPE Assay and demonstrate its diagnostic utility in the context of ambiguous melanocytic lesions. Read More

    Nevi and lasers: Practical considerations.
    Lasers Surg Med 2018 Jan 21;50(1):7-9. Epub 2017 Nov 21.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Lasers are increasingly used for elective ablation of melanocytic nevi (MN). However, the associated risks of treating MN with lasers are debated and not well studied. Theoretical risks include inadvertently treating a melanoma mistaken for a nevus, the inability to remove all nevus cells and the possibility for residual cells to undergo malignant transformation, and the difficulty in clinically monitoring the remnant nevus for melanoma progression. Read More

    [Diagnosis and Therapy of Iris Lesions].
    Klin Monbl Augenheilkd 2017 Dec 20;234(12):1541-1554. Epub 2017 Nov 20.
    The most common iris lesions are iris nevi, iris melanomas and iris pigment epithelium cysts. However, there is an abundance of rare differential diagnoses that have to be considered, including other melanocytic and non-melanocytic lesions. Diagnostic tools include the slit lamp examination, gonioscopy, tonometry, transillumination, ultrasound biomicroscopy (UBM), optical coherence tomography, fluorescein angiography and standardized photography-assisted documentation. Read More

    Regressed melanocytic nevi secondary to pembrolizumab therapy: an emerging melanocytic dermatologic effect from immune checkpoint antibody blockade.
    Int J Dermatol 2017 Nov 20. Epub 2017 Nov 20.
    Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Background: Immune checkpoint antibody blockade is an emerging therapeutic option for treating certain cancers including melanoma. This therapy is associated with dermatologic and systemic toxicities, some of which are more severe than others and may require withholding therapy.

    Case Reports: We report two patients with melanocytic nevi that regressed with pembrolizumab therapy. Read More

    The diagnostic value and histologic correlate of distinct patterns of shiny white streaks for the diagnosis of melanoma: a retrospective, case-control study.
    J Am Acad Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
    Background: Shiny white streaks (SWS) are best visualized with polarized dermoscopy, and correlate with dermal fibroplasia histopathologically. SWS have been described at higher frequencies in melanomas than benign nevi.

    Objective: We assessed the diagnostic value of different patterns of SWS and their histologic correlate in melanocytic lesions. Read More

    Keratinocyte Sonic Hedgehog Up-regulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion.
    J Invest Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Electronic address:
    Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Read More

    Pigmented Spindle Cell Nevus of Reed of the Eyelid.
    Ocul Oncol Pathol 2017 Sep 27;3(3):176-180. Epub 2017 Jan 27.
    Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.
    Purpose: To report the clinical, pathological, and immunohistochemical features of the first pigmented spindle cell nevus (PSCN) of Reed documented to have appeared in the eyelid.

    Methods: The findings of clinical and histopathological examination are presented, along with differential diagnoses and a review of the pertinent literature.

    Case: A 3-year-old boy presented with a rapidly growing, heavily pigmented left lower lid papule raising the concern of malignancy, warranting excisional biopsy. Read More

    Role of amniotic membrane and full-thickness skin graft in reconstruction of kissing nevus of eyelids.
    Indian J Ophthalmol 2017 Nov;65(11):1219-1221
    Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 20-year-old girl presented with a large pigmented lesion over the temporal aspect of left lateral canthus involving the lateral one-third of both eyelids, since birth. A slow increase in its size had been noticed for the past 2 years. On examination, a hairy nevus measuring 34 mm × 22 mm was noticed involving left eyelid skin, the mucocutaneous junction (MCJ), palpebral conjunctiva, and lateral canthus. Read More

    Resection of melanocytic nevi as a potential treatment of anti-NMDAR encephalitis patients without tumor: report of three cases.
    Neurol Sci 2018 Jan 11;39(1):165-167. Epub 2017 Nov 11.
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    The most common underlying tumor associated with anti-N-methyl D-aspartate-receptor (NMDAR) encephalitis is ovarian teratoma. Resection of the underlying tumor may decrease exposure of autoantigen and make for faster response of immunotherapy and less relapse frequency. Similar to teratoma, expression of NMDAR in human epidermal melanocytes was suspected recently. Read More

    Expression of Glut-1 in Malignant Melanoma and Melanocytic Nevi: an Immunohistochemical Study of 400 Cases.
    Pathol Oncol Res 2017 Nov 11. Epub 2017 Nov 11.
    Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studnickova 2, 12800, Prague 2, Czech Republic.
    The glucose transporter-1 (Glut-1) is a cell membrane glycoprotein involved in glucose uptake. An increased expression of Glut-1 is an important cell adaptation mechanism against hypoxia. An upregulation of Glut-1 can be found in several types of malignant tumors, which are able to reprogram their metabolism from oxidative phosphorylation to aerobic glycolysis (Warburg effect). Read More

    Integration of dermoscopy and reflectance confocal microscopy for distinguishing melanomas from nevi of the breast area.
    J Eur Acad Dermatol Venereol 2017 Nov 10. Epub 2017 Nov 10.
    Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
    Background: Nevi of special sites encompass a class of benign lesions characterized by the presence of atypical clinical and histopathological features that can be difficult to distinguish from melanoma. Dermoscopy and reflectance confocal microscopy may improve the clinical assessment of melanocytic lesions to avoid unnecessary excisions.

    Objectives: The aim of this study was to assess the value of specific dermoscopic and confocal criteria in distinguishing melanomas from nevi of the breast area. Read More

    Collision Tumor between Trichofolliculoma and Melanocytic Nevus.
    Int J Trichology 2017 Oct-Dec;9(4):181-183
    Department of Pathology, Clínica Las Condes, Santiago, Chile.
    Trichofolliculoma (TF) is a hamartomatous hair follicle-related tumor, clinically described as a dome-shaped papule with a central pore crossed by one or more silky white hairs. Histologically, it described as a cystic cavity containing keratinous debris, hair shaft fragments, and numerous hair follicles arising from its linings. Collision or compound tumors are a coexistence of two or more identifiable tumors in the same lesion. Read More

    Reinterpreting dermoscopic pigment network with reflectance confocal microscopy for identification of melanoma-specific features.
    J Eur Acad Dermatol Venereol 2017 Nov 8. Epub 2017 Nov 8.
    Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
    Background: Pigment network is an important dermoscopic feature for melanocytic lesions, but alterations in grid line thickness are also observed in melanomas.

    Objective: To investigate features of thick, thin and mixed pigment networks at dermoscopy and their respective features at reflectance confocal microscopy (RCM) for differential diagnosis, correlated with histology.

    Methods: All melanocytic lesions with histological diagnosis, evaluated between January 2010 and May 2014, were enrolled and classified according to dermoscopy evaluation of the pigment networks: thin, thick and mixed. Read More

    Immunohistochemical expression of vitamin D receptor in melanocytic nevi and cutaneous melanoma. A case-control study.
    Br J Dermatol 2017 Nov 6. Epub 2017 Nov 6.
    Melanoma and Skin Cancer Unit, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Background: Vitamin D (VD) deficiency is associated with higher risk of cancer, possibly due to anti-proliferative, anti-angiogenic, pro-apoptotic, cell-differentiating and anti-invasive effects. The anti-carcinogenic role of VD in melanoma is still a matter of debate. Loss of nuclear and cytoplasmic vitamin D Receptor (VDR) expression in melanoma cells has been reported. Read More

    Eccrine-Centric Melanocytic Nevus.
    Am J Dermatopathol 2017 Oct 27. Epub 2017 Oct 27.
    *Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL; †Metropolitan Dermatologic Surgery, Atlanta, GA; ‡Pathology and Laboratory Medicine Service, James A. Haley VA Hospital, Tampa, FL; §Georgia Dermatopathology, Savannah, GA; and ¶Department of Dermatology, University of Florida, Gainesville, FL.
    Benign melanocytic neoplasms present with a diverse array of well-known histopathologic patterns. It is imperative to recognize the benign patterns to render accurate diagnoses. We describe here an interesting and hitherto not described low-power architectural pattern of a benign melanocytic lesion: eccrine-centric melanocytic nevus. Read More

    Population-Based Analysis of Histologically Confirmed Melanocytic Proliferations Using Natural Language Processing.
    JAMA Dermatol 2018 Jan;154(1):24-29
    Department of Medicine, University of Washington School of Medicine, Seattle.
    Importance: Population-based information on the distribution of histologic diagnoses associated with skin biopsies is unknown. Electronic medical records (EMRs) enable automated extraction of pathology report data to improve our epidemiologic understanding of skin biopsy outcomes, specifically those of melanocytic origin.

    Objective: To determine population-based frequencies and distribution of histologically confirmed melanocytic lesions. Read More

    Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure.
    PLoS One 2017 1;12(11):e0186958. Epub 2017 Nov 1.
    Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
    We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later. Read More

    Dermoscopy of congenital melanocytic nevi: a ten-year follow-up study and comparative analysis with acquired melanocytic nevi arising in prepubertal age.
    Eur J Dermatol 2017 Oct;27(5):505-510
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Italy.
    Dermoscopic characteristics of congenital melanocytic nevi (CMN) have been reported, however, dermoscopic variation during long-term follow-up and direct comparative analyses with acquired melanocytic nevi (AMN) are poorly documented. To assess dermoscopic changes of CMN (including lesions present at birth or appearing within the first two years of age) after a long-term period and evaluate possible dermoscopic differences with AMN arising during prepubertal age. We re-analysed clinical and dermoscopic features of CMN, investigated ten years earlier. Read More

    Gene expression signature as an ancillary method in the diagnosis of desmoplastic melanoma.
    Hum Pathol 2017 Dec 24;70:113-120. Epub 2017 Oct 24.
    Memorial Sloan Kettering Cancer Center, New York, NY, 10065. Electronic address:
    Desmoplastic melanoma (DM) is a rare fibrosing variant of melanoma that can be difficult to diagnose. One of the diagnostic challenges is its distinction from a melanocytic nevus with desmoplasia. Here we investigate the use of a 23-gene signature, which has previously been shown to distinguish benign from malignant melanocytic neoplasms. Read More

    Laser treatment of congenital melanocytic nevi: a systematic review.
    Br J Dermatol 2017 Oct 27. Epub 2017 Oct 27.
    Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Centre, University of Amsterdam, The Netherlands.
    Recent studies on congenital melanocytic nevi (CMN) indicate a lower risk for melanoma than assumed for many years. As a result, the treatment paradigm in CMN shifted from complete removal to cosmetically acceptable, less invasive treatment options such as laser treatment. Our objective was to systematically review the efficacy and safety of laser therapy for CMN. Read More

    Acquisition of Somatic NRAS Mutations in Central Nervous System Melanocytes: A Predisposing Risk Factor to Primary Melanoma of the Central Nervous System, a Frequently Forgotten Pitfall in Congenital Nevi.
    Am J Dermatopathol 2017 Oct 17. Epub 2017 Oct 17.
    Departments of *Pathology, and †Dermatology, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain.
    Congenital melanocytic nevi (CMN) are benign melanocytic proliferations that are usually present at birth. A somatic mosaicism for an NRAS point mutation is responsible for the several phenotypic abnormalities that may be associated with congenital nevi. We report the case of a 7-year-old boy with a proliferative nodule (PN) arising in a Giant CMN completely excised and with several visceral and intraspinal melanoma metastases with no evidence of primary cutaneous melanoma. Read More

    Serial Tissue Expansion at the Same Site in Pediatric Patients: Is the Subsequent Expansion Faster?
    Arch Plast Surg 2017 Nov 26;44(6):523-529. Epub 2017 Oct 26.
    Department of Plastic and Reconstructive Surgery, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, Seoul, Korea.
    Background: Serial tissue expansion is performed to remove giant congenital melanocytic nevi. However, there have been no studies comparing the expansion rate between the subsequent and preceding expansions. In this study, we analyzed the rate of expansion in accordance with the number of surgeries, expander location, expander size, and sex. Read More

    Classifying dermoscopic patterns of naevi in a case-control study of melanoma.
    PLoS One 2017 17;12(10):e0186647. Epub 2017 Oct 17.
    Dermatology Research Centre, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.
    Changes in dermoscopic patterns of naevi may be associated with melanoma; however, there is no consensus on which dermoscopic classification system is optimal. To determine whether different classification systems give comparable results and can be combined for analysis, we applied two systems to a case-control study of melanoma with 1037 participants: 573 classified using a "1/3 major feature" system, 464 classified based on rules of appearance, and 263 classified with both criteria. There was strong correlation for non-specific (Spearman R = 0. Read More

    Clinical and dermoscopic characterization of pediatric and adolescent melanomas: Multicenter study of 52 cases.
    J Am Acad Dermatol 2018 Feb 9;78(2):278-288. Epub 2017 Oct 9.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
    Background: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse, and this may in part contribute to delay in detection and thicker tumors.

    Objective: To analyze the clinicodermoscopic characteristics of PM.

    Methods: Retrospective study of 52 melanomas diagnosed in patients before the age of 20 years. Read More

    Agminated segmental plaque-type blue nevus associated with hypertrichosis and soft tissue hypertrophy: Report of a case and review of the literature.
    Pediatr Dermatol 2017 Oct 11. Epub 2017 Oct 11.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Blue nevi are common skin neoplasms that typically present as asymptomatic solitary papules, although they may rarely occur in an agminated configuration. We describe a case of agminated blue nevus in a segmental facial distribution associated with soft tissue hypertrophy and hypertrichosis in a 16-year-old boy and present a review of the literature. Although they are generally considered to be benign, concurrent soft tissue changes occurring within an agminated blue nevus should be investigated thoroughly to exclude alternate diagnoses. Read More

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