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    Topography of Protein Kinase C βII in Benign and Malignant Melanocytic Lesions.
    Int J Surg Pathol 2017 Apr 1:1066896917706026. Epub 2017 Apr 1.
    2 Laboratory of Pathology, Division of Morphology, University of Crete, Heraklion, Greece.
    Background: Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro.

    Objective: To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations.

    Methods: Expression of PKC-βII was semiquantitatively assessed in the various existing compartments (intraepidermal [not nested], junctional [nested], and dermal) of benign (n = 43) and malignant (n = 28) melanocytic lesions by immunohistochemistry. Read More

    Noninvasive RCM for Differentiation of Melanotic Macules From Melanocytic Lesions-Blinded Evaluation of a Series of 42 Pigmented Macules.
    Dermatol Surg 2017 Apr 19. Epub 2017 Apr 19.
    *Department of Dermatology, Paracelsus Medical University of Salzburg, Salzburg, Austria; †Department of Dermatology, Medical University of Graz, Graz, Austria, Europe.
    Background: Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination.

    Objective: To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions.

    Patients And Methods: Reflectance confocal microscopy images of 42 pigmented macules on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together. Read More

    Melanocytes Containing Large Nuclei and Abundant Pale Cytoplasm in Melanocytic Nevi.
    Am J Dermatopathol 2017 May;39(5):414-416
    *Pathology Unit, Medical and Surgical Sciences Department, University of Cantabria and IDIVAL, Santander, Spain †Anatomical Pathology Service, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria and IDIVAL, Santander, Spain ‡Dermatology Service, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria and IDIVAL, Santander, Spain.

    Oral pigmentations in physiologic conditions, post inflammatory affections and systemic diseases.
    G Ital Dermatol Venereol 2017 Apr 19. Epub 2017 Apr 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy -
    Melanocytes are found throughout the oral mucosa but usually go unnoticed because of their relatively low level of pigment production. When focally or generally active in pigment production or proliferation they may be responsible for several affections in the oral mucosae ranging from physiologic pigmentation, systemic diseases to malignant neoplasms. The diagnosis of oral pigmentations (OP) is usually challenging for the physician, but a careful examination of the oral cavity may reveal the first manifestation of underlying systemic diseases. Read More

    Pigmented epithelioid melanocytoma (animal type melanoma): An institutional experience.
    J Am Acad Dermatol 2017 Apr 14. Epub 2017 Apr 14.
    Department of Dermatology, University of Rochester School of Medicine, Rochester, New York; Department of Pathology, University of Rochester School of Medicine, Rochester, New York.
    Background: Pigmented epithelioid melanocytoma (PEM) is an uncommon, recently described entity with unknown biologic behavior. There is a high rate of regional metastases, but limited evidence of distant metastases or disease-related death.

    Objective: We sought to report our series of patients given a diagnosis of PEM at our institution and provide mutational analysis of genes commonly implicated in melanoma in 2 cases. Read More

    SF3B1 and BAP1 mutations in blue nevus-like melanoma.
    Mod Pathol 2017 Apr 14. Epub 2017 Apr 14.
    Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
    Blue nevi are melanocytic tumors originating in the cutaneous dermis. Malignant tumors may arise in association with or resembling blue nevi, so called 'blue nevus-like melanoma', which can metastasize and result in patient death. Identifying which tumors will behave in a clinically aggressive manner can be challenging. Read More

    A retrospective epidemiological study of skin diseases among pediatric population attending a tertiary dermatology referral center in Northern Greece.
    Clin Cosmet Investig Dermatol 2017 3;10:99-104. Epub 2017 Apr 3.
    First Department of Dermatology, Aristotle University Medical School, Thessaloniki, Greece.
    Background: The incidence of skin diseases in children is influenced by hereditary, social, and environmental factors. The objective of this study was to determine the incidence of pediatric dermatoses at a University Hospital in Northern Greece.

    Patients And Methods: We reviewed epidemiologic data of 940 patients, aged 0-18 years, who were referred to the outpatient clinic of a University Hospital between January 2013 and December 2015. Read More

    The diagnosis and management of the Spitz nevus in the pediatric population: a systematic review and meta-analysis protocol.
    Syst Rev 2017 Apr 13;6(1):81. Epub 2017 Apr 13.
    Division of Plastic Surgery, University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
    Background: Spitz nevi are uncommon melanocytic neoplasms found in children. Historically, the diagnosis and management of these tumors has lacked consensus among oncologists, pathologists, plastic surgeons, and dermatologists. Once interpreted and treated as a "juvenile melanoma", many have argued for the benignancy of such tumors in certain patient age groups, encouraging a conservative approach. Read More

    Surgical suturing-induced melanocytic nevi. A new type of eruptive melanocytic nevi?
    J Dermatol Case Rep 2016 Nov 30;10(3):49-52. Epub 2016 Nov 30.
    2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, "Attikon" University General Hospital, 1 Rimini str, 12462, Chaidari, Athens, Greece.
    Background: Nevogenesis is a complex process involving several pathogenetic mechanisms, including genetic factors, hormonal influences and UV-radiation. Trauma has been described as a triggering factor for an alternative pathway of nevogenesis. Eruptive melanocytic nevi (EMN), related either to immunosuppression or to blistering disorders, represent a special type of nevi probably induced by the disruption of the dermo-epidermal junction and consequent proliferation of quiescent pigment cells during re-epithelization. Read More

    Myxoid Spitz Nevi: Report of 6 Cases.
    Am J Dermatopathol 2017 Mar 27. Epub 2017 Mar 27.
    *Department of Cellular Pathology, Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain; †Biomedical Investigation Institute of A Coruña, CellCOM-SB Group, A Coruña, Spain; ‡Department of Cellular Pathology, Hospital de la Reina, Cellular Pathology, Ponferrada, Spain; §Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain; ¶Universidad Complutense, Medical School, Instituto i+12, Madrid, Spain; and ‖Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA.
    Mucin deposition in Spitz nevus seems to be a very rare phenomenon, as there have only been 3 cases previously published. We report 6 additional cases, half of them in women, and half in men. The ages of the patients varied from 5 to 47 years (mean = 30. Read More

    Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes.
    Cancer Epidemiol Biomarkers Prev 2017 Apr 4. Epub 2017 Apr 4.
    Myriad Genetic Laboratories, Inc.
    Background: Histopathologic examination alone can be inadequate for diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature was clinically validated as an ancillary diagnostic test to differentiate benign nevi from melanoma. The current study assessed the performance of this test in an independent cohort of melanocytic lesions against clinically proven outcomes. Read More

    Risk of melanocytic nevi and nonmelanoma skin cancer in children after allogeneic hematopoietic stem cell transplantation.
    Bone Marrow Transplant 2017 Apr 3. Epub 2017 Apr 3.
    Department of Medicine, Dermatology Program, Boston Children's Hospital, Boston, MA, USA.
    There is a known increased risk of skin cancer in the adult population after hematopoietic stem cell transplantation (HSCT). However, late dermatologic effects that children may experience after HSCT have not been well described. The primary objective of this study was to characterize nevi and skin cancers affecting children after allogeneic HSCT. Read More

    Clinicopathological and immunohistochemical analysis of oral melanocytic nevi and review of the literature.
    J Stomatol Oral Maxillofac Surg 2017 Mar 29. Epub 2017 Mar 29.
    Dental School of University of Seville, Spain.
    Introduction: Oral melanocytic nevi (OMNs) are uncommon benign melanocytic tumors, histologically similar to their cutaneous counterparts. The aim of this study was twofold: to contribute to the epidemiology with a literature review with the first Spanish series of OMNs, and to report on clinicopathological, immunohistochemical and demographic findings.

    Materials And Methods: A retrospective analysis of cases attended over the period 1999-2010 was carried out using data drawn from the pathology unit files at two public hospitals in the Spanish region of Andalusia, serving between them a population of 823. Read More

    A Diagnostic Algorithm Combining Immunohistochemistry and Molecular Cytogenetics to Diagnose Challenging Melanocytic Tumors.
    Appl Immunohistochem Mol Morphol 2017 Mar 30. Epub 2017 Mar 30.
    *Inserm U1078 Departments of †Molecular Genetics and Histocompatibility ‡Pathology, CHRU Brest §European University of Brittany, Brest, France.
    Some melanocytic tumors are diagnostic challenges and require ancillary tools in helping the pathologists to determine their potential of malignancy. We intend to propose a diagnostic algorithm in helping to classify challenging melanocytic tumors combining histology, immunohistochemistry, and cytogenetics. We report on 24 spitzoid and/or misdiagnosed melanocytic tumors studied with a triple p16, Ki-67, and HMB45 immunohistochemistry score, fluorescent in situ hybridization (FISH) with melanoma-dedicated and non-melanoma-dedicated probes and comparative genomic hybridization on DNA microarray (CGH array). Read More

    Tissue expansion in the treatment of giant congenital melanocytic nevi of the upper extremity.
    Medicine (Baltimore) 2017 Mar;96(13):e6358
    aDepartment of Plastic Surgery bDepartment of Operating Theater, Henan Provincial People's Hospital, Zhengzhou City, Henan Province, China.
    The aim of our study was to use tissue expansion for the treatment of giant congenital melanocytic nevi of the upper extremity and examine potential advantages over traditional techniques.There were 3 stages in the treatment of giant congenital melanocytic nevi of the upper extremities using tissue expansion: first, the expander was inserted into the subcutaneous pocket; second, the expander was removed, lesions were excised, and the wound of the upper extremity was placed into the pocket to delay healing; third, the residual lesion was excised and the pedicle was removed. The pedicle flap was then unfolded to resurface the wound. Read More

    Diagnostic performance of the MelaFind device in a real-life clinical setting.
    J Dtsch Dermatol Ges 2017 Apr 23;15(4):414-419. Epub 2017 Mar 23.
    Department of Dermatology, Venereology, and Allergology, University Medical Center, Ruprecht-Karl University, Heidelberg, Germany.
    Background: MelaFind is a multispectral computer vision system intended to -provide additional information on melanocytic lesions suspected of being melanoma by -objectively assessing their three-dimensional morphology.

    Objectives: Analysis of the diagnostic performance of MelaFind in a real-life clinical setting.

    Patients And Methods: In this observational study, 360 pigmented skin lesions (PSL) in 111 patients were assessed by office-based dermatologists using MelaFind. Read More

    Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.
    Biomed Res Int 2017 26;2017:6803756. Epub 2017 Feb 26.
    Chair of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical College, Grzegórzecka 16, 31-351 Kraków, Poland.
    Background. Dendritic cells could be involved in immune surveillance of highly immunogenic tumors such as melanoma. Their role in the progression melanocytic nevi to melanoma is however a matter of controversy. Read More

    Giant benign intradermal melanocytic nevus of rapid onset.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Weill Cornell Medical College, New York, New York.
    Benign melanocytic nevi are slowly growing acquiredor congenital tumors with varied morphology,commonly encountered in dermatology clinics. Anytumor with rapid clinical growth must be assessedcarefully in order to exclude malignancy. We report awoman with a histopathologically benign intradermalnevus that presented as a rapidly evolving largecutaneous mass on the ear. Read More

    Patterns of distribution of giant congenital melanocytic nevi (GCMN): The 6B rule.
    J Am Acad Dermatol 2017 Apr;76(4):689-694
    Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain; "Centro de Investigación Biomédica en Red en Enfermedades Raras, Instituto de Salud Carlos III", Barcelona, Spain. Electronic address:
    Background: Garment-related terms have been used to describe the pattern of distribution of giant congenital melanocytic nevi (GCMN).

    Objective: We sought to describe patterns of distribution of GCMN and propose a classification scheme.

    Methods: Photographic records of patients with GCMN from the Hospital Clinic of Barcelona were analyzed and a classification based on observed GCMN distribution patterns was created. Read More

    Dermoscopic Findings of an Unusual Acral Nevus on the Hand of a Child.
    Pediatr Dermatol 2017 Mar 20. Epub 2017 Mar 20.
    Department of Dermatology, Downstate Medical Center, State University of New York, Brooklyn, New York.
    Distinguishing benign acral nevi from small early acral melanomas may be challenging in certain cases. Dermoscopy is a noninvasive imaging technique that can help clinicians better visualize deeper lesion structures and thus more easily differentiate benign nevi from melanoma. We report the case of a 13-year-old girl with a changing dark brown to black macule with a central papular component on the volar surface of the right third finger. Read More

    Immunohistochemical Study of Vasculogenic Mimicry and Angiogenesis in Melanocytic Tumors of the Eye and the Periocular Area.
    Anticancer Res 2017 03;37(3):1113-1120
    Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece.
    Background/aim: The ability of a tumor to grow requires a sufficient blood supply. Microvascular density is considered the standard for assessing the neovasculature. Tumor cell vasculogenic mimicry refers to the formation of tumor cell-lined vessels that contribute to tumor neovascularization. Read More

    Impression Cytology in a Series of Clinically Diagnosed Ocular Surface Melanocytic Lesions.
    J Ophthalmic Vis Res 2017 Jan-Mar;12(1):17-22
    Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
    Purpose: To report impression cytology (IC) results of clinically diagnosed ocular surface melanocytic lesions.

    Methods: Ten patients with a clinical diagnosis of an ocular surface melanocytic lesion underwent IC using cellulose acetate strips and Periodic acid Schiff-Papanicolaou staining. Excisional biopsy of lesions was performed in case of observing atypical cells on IC or at the patient's request, and excised specimens were subjected to histopathological analysis. Read More

    Congenital melanocytic nevus on the lower eyelid treated with continuous wave and superpulsed CO2 laser followed by erbium laser.
    J Cosmet Laser Ther 2017 Feb 17:1-3. Epub 2017 Feb 17.
    a Private Practice , Abrusci Studio , Milan , Italy.
    There are several therapeutic options to treat congenital melanocytic nevi. The motivations for the treatment of small- to medium-sized congenital nevi located on the face or other sensitive areas are frequently cosmetic. The choice of therapy depends on the operator's expertise and on the likelihood of improved cosmesis. Read More

    Melanoma and melanocytic nevi in paediatric patients: a single institution experience.
    G Ital Dermatol Venereol 2017 Mar 14. Epub 2017 Mar 14.
    Unità Operativa di Dermatologia, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Policlinico Sant'Orsola-Malpighi, Università di Bologna, Bologna, Italy.
    Background: Melanoma is an infrequent neoplasm in children and adolescents. The number of consultancies for melanocytic nevi control in the paediatric population is increased by the major anxiety of parents and paediatricians.

    Methods: A retrospective chart review was performed in order to evaluate the incidence rate of melanoma, Spitz nevi, congenital and acquired melanocytic nevi in patients aged 14 years or less and referred to our institution from April 2010 to September 2015. Read More

    Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: a review.
    Int J Dermatol 2017 Mar 7. Epub 2017 Mar 7.
    University of Leiden, Department of Dermatology, Leiden, the Netherlands.
    Recently, the unregulated use of untested synthetic alpha-melanocyte-stimulating hormone (α-MSH) analogues, commonly known as melanotan I and II, appears to have increased. These analogues are primarily used for their tan-stimulating effects. Dermatologists see many patients in their clinic who tan. Read More

    Long Noncoding RNA PVT1 as a Novel Diagnostic Biomarker and Therapeutic Target for Melanoma.
    Biomed Res Int 2017 7;2017:7038579. Epub 2017 Feb 7.
    Department of General Surgery, The 253rd Hospital of PLA, Hohhot, Inner Mongolia 010051, China.
    Accumulating evidences indicated that plasmacytoma variant translocation 1 (PVT1) plays vital roles in several cancers. However, the expression, functions, and clinical values of PVT1 in melanoma are still unknown. In this study we measured the expression of PVT1 in clinical tissues and serum samples and explored the diagnostic value of PVT1 for melanoma and the effects of PVT1 on melanoma cell proliferation, cell cycle, and migration. Read More

    Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi.
    J Med Life 2017 Jan-Mar;10(1):85-89
    Department of Dermatology, "Dr. Victor Babeş" Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania ; Department of Pharmacology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
    Reelin is an extracellular signaling protein synthesized by Cajal-Retius cells in utero and early after birth, its presence being signaled in adult life too. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons. We investigated the reelin presence and its receptors, VLDLR and ApoER2, in melanocytic nevi considering the neural crest origin of the nevus cells and their migration into skin during embrionary period. Read More

    Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma.
    Am J Dermatopathol 2017 Feb 20. Epub 2017 Feb 20.
    *Department of Dermatology, Yale University School of Medicine, New Haven, CT; †Smilow Cancer Center, New Haven, CT; ‡Department of Plastic Surgery, Plastic Surgery Hospital, Peking Union Medical College and the Chinese Academy of Medical Science, Beijing, China; §Department of Dermatology, School of Medicine, University of Balamand, Beirut, Lebanon; ¶Department of Genetics, Yale School of Medicine, New Haven, CT; ‖Protea Biosciences, Inc, Morgantown, WV; and **Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN.
    Histopathological interpretation of proliferative nodules occurring in association with congenital melanocytic nevi can be very challenging due to their similarities with congenital malignant melanoma and malignant melanoma arising in association with congenital nevi. We hereby report a diagnostically challenging case of congenital melanocytic nevus with proliferative nodules and ulcerations, which was originally misdiagnosed as congenital malignant melanoma. Subsequent histopathological examination in consultation by one of the authors (R. Read More

    Dermoscopic and confocal features of an axillary "special site" nevus.
    Dermatol Pract Concept 2017 Jan 31;7(1):55-58. Epub 2017 Jan 31.
    Department of Dermatology, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    "Nevi of special sites" is a term that denotes melanocytic nevi presenting in specific anatomic locations including the scalp, genital area, flexural sites, and acral sites [1]. Nevi from these anatomic sites display at times histopathologic features that may lead the reading pathologist to recommend re-excision of these benign nevi. Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that allows for visualization of epidermal, dermal-epidermal junctional (DEJ), and superficial dermal tissue structures at cellular level resolution. Read More

    Reflectance confocal microscopy features of facial angiofibromas.
    Dermatol Pract Concept 2017 Jan 31;7(1):51-54. Epub 2017 Jan 31.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.
    Facial angiofibromas are benign tumors presenting as firm, dome-shaped, flesh-colored to pink papules, typically on the nose and adjoining central face. Clinically and dermoscopically they can mimic melanocytic nevi or basal cell carcinomas (BCC). Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that is useful in diagnosing melanocytic and non-melanocytic facial lesions. Read More

    Congenital melanocytic nevi in young children: Histopathologic features and clinical outcomes.
    J Am Acad Dermatol 2017 May 24;76(5):941-947. Epub 2017 Feb 24.
    Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
    Background: Although only large congenital melanocytic nevi (CMN) are associated with a significantly high risk for malignant transformation, CMN of all sizes are prone to changes in clinical appearance in early childhood and thus are often biopsied or excised. While CMNs typically exhibit benign behavior, atypical histopathologic findings might be common and may prompt additional unnecessary procedures.

    Objective: To assess the prevalence and associated clinical outcomes of atypical histopathologic features in CMN in children. Read More

    Atypical cellular blue nevus or malignant blue nevus?
    An Bras Dermatol 2017 Jan-Feb;92(1):110-112
    Division of Dermatology, Internal Medicine Department - Medical School of Ribeirão Preto - Universidade de São Paulo- Ribeirão Preto (SP) -Brazil.
    Blue nevus is a benign melanocytic lesion whose most frequent variants are dendritic (common) blue nevus and cellular blue nevus. Atypical cellular blue nevus presents an intermediate histopathology between the typical and a rare variant of malignant blue nevus/melanoma arising in a cellular blue nevus. An 8-year-old child presented a pigmented lesion in the buttock since birth, but with progressive growth in the last two years. Read More

    Intense Pulsed Light Alone and in Combination with Erbium Yttrium-Aluminum-Garnet Laser on Small-to-Medium Sized Congenital Melanocytic Nevi: Single Center Experience Based on Retrospective Chart Review.
    Ann Dermatol 2017 Feb 3;29(1):39-47. Epub 2017 Feb 3.
    Department of Dermatology, Incheon St. Mary's Hospital, Incheon, Korea.
    Background: Treatment of congenital melanocytic nevi (CMN) with intense pulsed light (IPL) has recently produced promising results.

    Objective: To evaluate the clinical and histological outcomes of small-to-medium sized CMN treated with IPL alone and in combination with erbium: yttrium-aluminum-garnet (Er: YAG) laser.

    Methods: We performed a retrospective chart review of 26 small-to-medium sized CMN treated as described above. Read More

    Dermoscopic Features of Small, Medium, and Large-Sized Congenital Melanocytic Nevi.
    Ann Dermatol 2017 Feb 3;29(1):26-32. Epub 2017 Feb 3.
    Department of Dermatology, Bezmialem Vakif University, Istanbul, Turkey.
    Background: Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma.

    Objective: To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. Read More

    Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
    Lab Invest 2017 Feb 20. Epub 2017 Feb 20.
    Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA.
    A comprehensive repertoire of human microRNAs (miRNAs) that could be involved in early melanoma invasion into the dermis remains unknown. To this end, we sequenced small RNAs (18-30 nucleotides) isolated from an annotated series of invasive melanomas (average invasive depth, 2.0 mm), common melanocytic nevi, and matched normal skin (n=28). Read More

    Clinical course, treatment modalities, and quality of life in patients with congenital melanocytic nevi - data from the German CMN registry.
    J Dtsch Dermatol Ges 2017 Feb;15(2):159-167
    Department of Dermatology, University of Lübeck, Germany.
    Background: Congenital melanocytic nevi (CMN) are associated with mental stress as well as medical risks for those affected. The German CMN registry was initiated in 2005. Herein, we present results from an interim analysis focusing on disease course, treatment modalities, and quality of life. Read More

    Reasons for rarity of anal melanocytic naevi.
    Australas J Dermatol 2017 Feb 17. Epub 2017 Feb 17.
    Central Medical Laboratory, Manama, Kingdom of Bahrain.
    In the last 16 years only seven definite cases of anal melanocytic naevi have been reported in the literature. We describe three new cases, none of which were suspected clinically and were incidentally diagnosed on histological examination of haemorrhoidectomy specimens. The infrequency of these special site flexural melanocytic lesions may be related to changes in the involutionary mechanisms of the anal melanocyte proliferation. Read More

    Common Skin Conditions in Children: Congenital Melanocytic Nevi and Infantile Hemangiomas.
    FP Essent 2017 Feb;453:33-37
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Congenital melanocytic nevi (CMN) are hamartomas present at birth that are composed of nevomelanocytes and thought to originate from faulty migration of precursor melanocytes in the neural crest. Classification is based on projected adult size of the lesion. CMN size correlates positively with risk of melanoma and neurocutaneous melanocytosis. Read More

    Basal cell carcinoma arising in a congenital melanocytic naevus in an adult.
    BMJ Case Rep 2017 Feb 13;2017. Epub 2017 Feb 13.
    Queen Victoria Hospital NHS Foundation Trust, East Grinstead, West Sussex, UK.
    Congenital melanocytic naevi (CMN) are common skin lesions. They harbour a risk of malignant transformation, and various lesions have been described as developing within them. A basal cell cancer occurring within a CMN has never previously been described. Read More

    Combined in vivo reflectance confocal microscopy and digital dermoscopy for follow up of patients at high risk of malignant melanoma: A prospective case series study.
    J Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatology, University Hospital Fundación Alcorcón, Rey Juan Carlos University, Madrid, Spain.
    Digital dermoscopy (DD) follow up is a useful strategy for monitoring patients at high risk of melanoma. Reflectance confocal microscopy (RCM) is a valuable second-level examination after dermoscopy for the evaluation of difficult to diagnose lesions. The aim of this study was to assess the value of RCM in routine DD monitoring of patients at high risk of melanoma. Read More

    Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas.
    Mod Pathol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
    We performed exome sequencing of 77 melanocytic specimens composed of Spitz nevi (n=29), Spitzoid melanomas (n=27), and benign melanocytic nevi (n=21), and compared the results with published melanoma sequencing data. Our study highlights the prominent similarity between Spitzoid and conventional melanomas with similar copy number changes and high and equal numbers of ultraviolet-induced coding mutations affecting similar driver genes. Mutations in MEN1, PRKAR1A, and DNMT3A in Spitzoid melanomas may indicate involvement of the protein kinase A pathway, or a role of DNA methylation in the disease. Read More

    Melanocytic nevus count and dermoscopic features do not differ in psoriatic patients undergoing biological agent versus conventional drug therapy.
    G Ital Dermatol Venereol 2017 Apr;152(2):126-131
    Department of Dermatology and Venereology, Faculty of Medicine, Bezmialem Vakif University Hospital, İstanbul, Turkey.
    Background: Psoriasis is a chronic immune-mediated disease and treatment of psoriasis includes conventional immunosuppressive agents and biological agents. There are a few data on the relationship between psoriasis and melanocytic lesions. Either benign or malignant proliferations may be seen with immunosuppressive treatment. Read More

    Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.
    Exp Mol Pathol 2017 Feb 1;102(2):198-202. Epub 2017 Feb 1.
    Department of Pathology, Division of Neuropathology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, United States. Electronic address:
    Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers in 11 conjunctival nevi, 10 primary acquired melanosis (PAM) lesions, and 11 conjunctival melanomas. Immunostains included the melanocytic markers HMB-45 and Melan-A, as well as the proliferative marker Ki-67. Read More

    Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes.
    Curr Opin Ophthalmol 2017 May;28(3):228-237
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
    Purpose Of Review: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus.

    Recent Findings: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. Read More

    Polypoid Spitz Nevus With a Halo Reaction.
    Am J Dermatopathol 2017 Feb;39(2):130-133
    *Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain;†Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, INER/CIENI, Hospital Angeles Lomas, Centro Medico ABC, Mexico City, Mexico; and‡Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense, I+12, Madrid, Spain.
    Approximately, 2% of Spitz nevi are polypoid; between 3.6% and 7.4% present with a halo reaction. Read More

    CLINICAL PROFILE AND TRIGGERING FACTORS FOR ACQUIRED, BILATERAL NEVUS OF OTA-LIKE MACULES.
    Cutan Ocul Toxicol 2017 Jan 25:1-14. Epub 2017 Jan 25.
    a Affiliated Hospital of Nanjing University of Chinese Medicine , Nanjing , China.
    BACKGROUD Acquired, bilateral nevus of Ota-like macules (ABNOM) is one of the most common dermal melanocytoses. Although there are some literatures on ABNOM, its clinical features and etiopathogenetic factors have not been fully understood. OBJECTIVE To determine the prevalence and characteristics of ABNOM among the Chinese patients. Read More

    Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance.
    Lab Invest 2017 Jan 16. Epub 2017 Jan 16.
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
    Melanocytes, a neural crest cell derivative, produce pigment to protect keratinocytes from ultraviolet radiation (UVR). Although melanocytic lesions such as nevi and cutaneous malignant melanomas are known to be associated with sun exposure, the role of UVR in oncogenesis is complex and has yet to be clearly elucidated. UVR appears to have a direct mutational role in inducing or promoting melanoma formation as well as an indirect role through microenvironmental changes. Read More

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