21,919 results match your criteria Nevi Melanocytic


Blue Rubber Bleb Nevus Syndrome: A Possible Cause for Growth Retardation and Pubertal Delay.

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Objective: To describe a rare case of Blue Rubber Bleb Nevus (BRBNS) with growth retardation and pubertal delay.

Clinical Presentation And Intervention: A 16-year-old boy with severe iron deficiency anemia was diagnosed with BRBNS, showing growth retardation and pubertal delay simultaneously. The patient was treated conservatively with intravenous iron therapy and his puberty advanced gradually. Read More

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December 2018

GNAQ Mutations in Diffuse and Solitary Choroidal Hemangiomas.

Ophthalmology 2018 Dec 8. Epub 2018 Dec 8.

Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical Center, New York, NY.

Purpose: GNAQ mutations have been identified in port wine stains (both syndromic and non-syndromic) and melanocytic ocular neoplasms. This study investigates the presence of GNAQ mutations in diffuse- (those associated with Sturge-Weber syndrome (SWS)) and solitary choroidal hemangiomas.

Participants: Tissue from 11 patients with the following diagnoses: port wine stain (n = 3), diffuse choroidal hemangioma (n = 1), solitary choroidal hemangioma (n = 6), choroidal nevus (n =1) METHODS: Ten specimens were interrogated with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT), a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 468 key cancer genes in formalin-fixed, paraffin-embedded tumors. Read More

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December 2018

Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.

Br J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.

Background: Reprogramming of energy metabolism to enhanced aerobic glycolysis has been defined as a hallmark of cancer.

Objective: To investigate the role of the mitochondrial proteins, β-subunit of the H -ATP synthase (β-F1-ATPase), and heat-shock protein 60 (HSP60), and the glycolytic markers, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase M2 (PKM2), as well as the bioenergetic cellular (BEC) index, in melanoma progression.

Material And Methods: The expression of energy metabolism proteins were assessed on a set of different melanoma cells representing the natural biological history of the disease: primary cultures of melanocytes, radial (WM35) and vertical (WM278) growth phases, and poorly (C81-61-PA) and highly (C8161-HA) aggressive melanoma cells. Read More

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December 2018
1 Read

Regression of multiple melanocytic nevi associated with nivolumab treatment for metastatic melanoma.

Int J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Clinical University Hospital of Valencia, Valencia, Spain.

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December 2018

Electrodissection for Nevus Lipomatosus Cutaneous Superficialis Removal.

J Am Acad Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Chief and profesor for dermatology department; Place where work was done: Universidad Autonoma de Nuevo León, Facultad de Medicina, Hospital Universitario ''Dr. José E. González'' Servicio de Dermatología, Monterrey, NL, México. Electronic address:

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December 2018

Identification of a robust methylation classifier for cutaneous melanoma diagnosis.

J Invest Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.

Early diagnosis improves melanoma survival, yet the histopathological diagnosis of cutaneous primary melanoma can be challenging even for expert dermatopathologists. Analysis of epigenetic alterations, such as DNA methylation, that occur in melanoma can aid in its early diagnosis. Using a genome-wide methylation screen, we assessed CpG methylation in a diverse set of 89 primary invasive melanomas, 73 nevi, and 41 melanocytic proliferations of uncertain malignant potential, classified based on interobserver review by dermatopathologists. Read More

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December 2018

Dermoscopic evaluation of melanocytic nevi changes after photoepilation techniques: a prospective study.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Clinic - Department of Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.

Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known.

Objective: Prospective study on clinical and dermatoscopic effects of photoepilation on melanocytic nevi.

Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up program from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Read More

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December 2018

Pigmented skin lesions displaying regression features: dermoscopy and reflectance confocal microscopy criteria for diagnosis.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.

Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Methods: Observational retrospective study. Read More

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December 2018
3 Reads

A diagnostically-challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23-gene expression signature (myPath Melanoma).

J Cutan Pathol 2018 Dec 2. Epub 2018 Dec 2.

Geisel School of Medicine at Dartmouth, Hanover, NH.

Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hybridization were used to arrive at the correct diagnosis. Read More

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December 2018
1 Read

Giant congenital facial melanocytic nevus.

Oman J Ophthalmol 2018 Sep-Dec;11(3):265-266

Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Giant Congenital Melanocytic Nevus (GCMNs) is mostly reported in area of trunk followed by limbs and head. Their incidence is <1:20,000 newborns It derives attention due to its association with malignant melanoma.The risk of developing malignant melanoma is between 5 to 10%. Read More

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December 2018

Spontaneous Regression of Large Congenital Melanocytic Nevi, With a Halo Rim in 17 Children With Large Scalp and Trunk Nevi During 45 Years: A Review of the Literature.

Clin Pediatr (Phila) 2018 Dec 3:9922818816421. Epub 2018 Dec 3.

1 University of Miami, Miami, FL, USA.

Background: Prior reports on large congenital melanocytic nevi (LCMN) do not provide a clear management approach to physicians to advise parents or patients. Whether the presence of a halo around the nevus can guide management has not been fully explored.

Design: Children born with an LCMN were observed without active intervention. Read More

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December 2018

[miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1360-1365

Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China.

Objective: To investigate the expression profile of miR-122-5p in melanoma tissues and the effect of miR-122-5p on the proliferation, cell cycle and apoptosis of human melanoma cell lines SK-MEL-110 and A375.

Methods: The expression profiles of miR-122-5p in melanoma and pigmented nevus tissues were detected using real-time fluorescence quantitative PCR (qRT-PCR). SK-MEL-110 and A375 cells transfected with miR-122-5p inhibitor or negative control inhibitor (NC) I were examined for miR-122- 5p expression using qRT-PCR and changes in cell proliferation, cell cycle and apoptosis using MTT assay or flow cytometry. Read More

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November 2018
2 Reads

Segmental epidermal nevus and mucosal neuromas associated with -related overgrowth spectrum disorder.

JAAD Case Rep 2018 Nov 14;4(10):1080-1082. Epub 2018 Nov 14.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

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November 2018

Bilateral Iris Mammillations in Amblyopic Eyes without Oculodermal Melanocytosis or Neurofibromatosis.

Case Rep Ophthalmol Med 2018 29;2018:2534042. Epub 2018 Oct 29.

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

Purpose: Iris mammillations are related to oculodermal melanosis and iris nevi. We report a rare case of bilateral simple iris mammillations without ocular melanosis or systemic neuronal disorders.

Case Report: A healthy 10-year-old Japanese girl was found incidentally to have bilateral iris mammillations while being treated for amblyopia. Read More

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October 2018

Identification of the potential prognostic genes of human melanoma.

J Cell Physiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Musculoskeletal Cancer Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China.

The melanoma is one of the most dangerous forms of skin diseases. It may spread to other parts of the body and cause serious illness and death. Early detection and diagnosis are crucial. Read More

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November 2018

Primary cutaneous apocrine carcinoma arising within a nevus sebaceus.

Cutis 2018 Oct;102(4):291-294

Nova Southeastern University College of Osteopathic Medicine/Largo Medical Center, Florida, USA.

Nevus sebaceus (NS)(organoid nevus) is a benign follicular neoplasm that commonly occurs on the scalp, face, or neck. With time, it may give rise to benign or malignant tumors such as trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma (BCC). Rarely, other types of neoplasms may develop. Read More

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October 2018
1 Read

Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Laboratory Medicine, Tongji hospital of Tongji University, Shanghai, China.

Objective: To investigate the effect of microRNA-137 (miR-137) on the migration and invasion of melanoma cells and its mechanism.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-137 in melanoma tissues and cells. miR-137 mimics, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) small interfering RNA and corresponding controls were transfected into A375 and WM451 cells by lipofection. Read More

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November 2018

Case for diagnosis. Ulcerated intradermal nevus simulating Sister Mary Joseph's nodule.

An Bras Dermatol 2018 Nov/Dec;93(6):905-906

Dermatology Service, Hospital do Servidor Público do Estado de São Paulo, São Paulo (SP), Brazil.

We report a case of a 76-year-old patient with a history of recent weight loss and ulcerated umbilical nodular lesion. Initially, we considered the diagnostic hypothesis of Sister Mary Joseph's nodule. However, histopathological evaluation revealed that it was an ulcerated intradermal nevus. Read More

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NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Braz J Med Biol Res 2018 Nov 23;52(1):e7952. Epub 2018 Nov 23.

Department of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. Read More

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November 2018

Spontaneous Regression of Medium-Sized Congenital Melanocytic Nevi: Report of 3 New Cases.

Actas Dermosifiliogr 2018 Oct 25. Epub 2018 Oct 25.

Centro Integral de Dermatología, Tucumán, Argentina.

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October 2018

Use of Telehealth Screening to Detect Diabetic Retinopathy and Other Ocular Findings in Primary Care Settings.

Telemed J E Health 2018 Nov 27. Epub 2018 Nov 27.

1 Wills Eye Hospital, Thomas Jefferson University , Philadelphia, Pennsylvania.

Purpose: To determine the incidence of diabetic retinopathy (DR) and other ocular findings in previously diagnosed diabetes using telehealth retinal screening with nonmydriatic fundus photography (nFP) in primary care physicians' offices.

Methods: A retrospective study based on electronic chart review was performed. All diabetic patients who participated in the Wills Eye Hospital (WEH) telehealth retinal screening program from July 1, 2012 to February 20, 2017 were included. Read More

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November 2018
2 Reads

Impact of clinical and personal data in the dermoscopic differentiation between early melanoma and atypical nevi.

Dermatol Pract Concept 2018 Oct 31;8(4):324-327. Epub 2018 Oct 31.

Dermatology Division, Department of Medical, Surgical and NeuroSciences, University of Siena, Siena, Italy.

Background: Differential diagnosis of clinically atypical nevi (aN) and early melanomas (eMM) still represents a challenge even for experienced dermoscopists, as dermoscopy alone is not sufficient to adequately differentiate these equivocal melanocytic skin lesions (MSLs).

Objectives: The objectives of this study were to investigate what were the most relevant parameters for noninvasive differential diagnosis between eMM and aN among clinical, personal, and dermoscopic data and to evaluate their impact as risk factors for malignancy.

Methods: This was a retrospective study performed on 450 MSLs excised from 2014 to 2016 with a suspicion of malignancy. Read More

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October 2018
3 Reads

Challenging clinical diagnosis of 2 lesions on the back: dermoscopy gives the clue.

Dermatol Pract Concept 2018 Oct 31;8(4):320-321. Epub 2018 Oct 31.

Department of Dermatology, Hospital Clínico San Carlos, Madrid, Spain.

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October 2018

Clinicopathologically problematic melanocytic tumors: a case-based review.

Dermatol Pract Concept 2018 Oct 31;8(4):306-313. Epub 2018 Oct 31.

Anatomic Pathology Unit, Hospital of Macerata, Italy.

Background: In spite of recent advances in the histopathological and molecular diagnosis of melanocytic neoplasms, a certain proportion of these lesions remain a daunting challenge for both the clinician and the pathologist.

Objectives: To emphasize the importance of close collaboration between clinicians and pathologists in case of problematic melanocytic lesions.

Patients: We report and discuss 5 problematic scenarios of melanocytic lesions, including tumoral melanosis, nevoid melanoma, lentiginous melanoma, spitzoid melanoma and BAPoma that may pose diagnostic difficulties in our practice. Read More

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October 2018
1 Read

Regressing Conjunctival Nevus in a Child.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):501-503

Liverpool Ocular Oncology Centre, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, England, UK.

Purpose: To report a case exhibiting drastic regression of a conjunctival nevus in a child.

Case Report: Spontaneous regression of conjunctival nevus is uncommon. We report the case of a nine-year-old Caucasian boy presenting a conjunctival-pigmented lesion situated at the plica semilunaris that underwent a significant reduction in size and color over a period of 15 months. Read More

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November 2018
3 Reads

Association of Phenotypic Characteristics and UV Radiation Exposure With Risk of Melanoma on Different Body Sites.

JAMA Dermatol 2018 Nov 21. Epub 2018 Nov 21.

Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Importance: Two pathways have been hypothesized for the development of cutaneous melanoma: one typically affects the head and neck, a site with chronic sun damage, and the other affects the trunk, which is less exposed to the sun. However, the possible cause of limb melanomas is less studied under this hypothesis.

Objective: To investigate the association between phenotypic characteristics, pattern of UV radiation exposure, and risk of melanoma on different body sites. Read More

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November 2018
2 Reads

Distinct Genomic Patterns in Pigmented Epithelioid Melanocytoma: A Molecular and Histologic Analysis of 16 Cases.

Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.

Dermatology, Feinberg School of Medicine, Northwestern University.

Pigmented epithelioid melanocytoma (PEM) is considered an intermediate grade melanocytic lesion that is histologically indistinguishable from epithelioid blue nevi associated with Carney complex. PEM are characterized by an intradermal population of heavily pigmented epithelioid-shaped melanocytes along with some spindled and dendritic melanocytes with frequent melanophages. These melanocytic tumors occasionally involve regional lymph nodes but only rarely result in distant metastases. Read More

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November 2018
4 Reads

Genetic variant in the NSDHL gene in a cat with multiple congenital lesions resembling inflammatory linear verrucous epidermal nevi.

Vet Dermatol 2018 Nov 25. Epub 2018 Nov 25.

Institute of Genetics, Vetsuisse Faculty, University of Bern, Länggassstrasse 120, 3001, Bern, Switzerland.

Background: The feline counterpart of human inflammatory linear verrucous epidermal nevus (ILVEN) has been described; however, the possible underlying developmental defect has not been investigated.

Objective: To report a case of multiple ILVEN-like lesions in a cat with a genetic variant in the NSDHL gene.

Animals: A 2-year-old, female, domestic short hair cat with a history of multiple alopecic, verrucous, hyperpigmented and erythematous skin lesions, following Blaschko's lines on the head, the limbs, the trunk and paw pads. Read More

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November 2018

Bilateral Phacomatosis Pigmentovascularis in a Young Male with Developmental Glaucoma and Varicose Veins.

J Curr Glaucoma Pract 2018 May-Aug;12(2):94-98. Epub 2018 Aug 1.

Senior Resident, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.

Aim: To report a case of bilateral phacomatosis pigmentovascularis (PPV), in a young male,presenting with developmental glaucoma and high myopia along with systemic features of klippel trenanauy weber (KTW) syndrome.

Background: The co-existence of oculodermal melanocytosis (ODM)and port-wine stain was termed PPV by Ota. Port-wine stain presents as part of Sturge-Weber syndrome (SWS). Read More

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August 2018
3 Reads

Clinical features and outcomes of spitzoid proliferations in children and adolescents.

Br J Dermatol 2018 Nov 22. Epub 2018 Nov 22.

Harvard Medical School.

Background: Spitzoid proliferations range from Spitz nevi to melanomas, and there are few studies describing clinical features and outcomes in the pediatric population.

Objectives: Determine clinical features and outcomes of a large pediatric cohort with histopathologically-confirmed Spitz tumors.

Methods: Retrospective cohort study of Boston Children's Hospital patients younger than 20 years with a histopathologic diagnosis of spitzoid proliferation from 1/1/1994 - 10/23/2012. Read More

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November 2018
2 Reads

Late-Onset Nevus Comedonicus With Follicular Epidermolytic Hyperkeratosis-Case Report and Review of the Literature.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Nevus comedonicus is a rare cutaneous follicular hamartoma, characterized by the clustering of papules with firm, blackened horny buffers. It is usually present at birth or during childhood, although few cases of late-onset disease have been described. We present a case of postmenopausal-onset nevus comedonicus in a 55-year-old white woman without relevant medical history. Read More

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November 2018

Proliferating Neurocristic Hamartoma Arising in a Giant Congenital Nevus: Comparative Genomic Hybridization Findings.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Deramatology, Hospital Universitario 12 de Octubre, Universidad Complutense, Instituto de Investigación I+12, Madrid, Spain.

Neurocristic cutaneous hamartomas (NCHs) are rarely reported tumors with divergent differentiation derived from persistently active pluripotent cells from the neural crest. They result from aberrant development of the neuromesenchyme, and they can express fibrogenic, melanocytic, and/or neurosustentacular differentiation. Thus, congenital melanocytic nevus also represents a neurocristic dysplasia of the skin in which cells are melanogenic cells arrested in development located in the reticular dermis, and nodular proliferative neurocristic hamartoma may arise within a congenital melanocytic nevus. Read More

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November 2018

NFAT1 enhances the effects of tumor-associated macrophages on promoting malignant melanoma growth and metastasis.

Biosci Rep 2018 Nov 20. Epub 2018 Nov 20.

Xiangya Hospital, Central South University, Changsha, China

Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. NFAT1 has been shown to promote melanoma growth and metastasis in vivo. We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties. Read More

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November 2018
3 Reads

Fusing fine-tuned deep features for skin lesion classification.

Comput Med Imaging Graph 2018 Nov 3;71:19-29. Epub 2018 Nov 3.

School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.

Malignant melanoma is one of the most aggressive forms of skin cancer. Early detection is important as it significantly improves survival rates. Consequently, accurate discrimination of malignant skin lesions from benign lesions such as seborrheic keratoses or benign nevi is crucial, while accurate computerised classification of skin lesion images is of great interest to support diagnosis. Read More

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November 2018
8 Reads

Eruptive melanocytic nevi associated with ponatinib.

JAAD Case Rep 2018 Nov 12;4(10):1052-1054. Epub 2018 Nov 12.

Service de Dermatologie, CHU Amiens Picardie, Amiens, France.

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November 2018
3 Reads

Not lost to follow-up: A rare case of CHILD syndrome in a boy reappears.

JAAD Case Rep 2018 Nov 9;4(10):1010-1013. Epub 2018 Nov 9.

Department of Dermatology, the University of California, Irvine, California.

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November 2018
1 Read

Functional Subunit Reconstruction of Giant Facial Congenital Melanocytic Nevi in Children With the Use of Matriderm and Skin Graft: Surgical Experience and Literature Review.

Eplasty 2018 5;18:e30. Epub 2018 Oct 5.

Plastic and Reconstructive Surgery Section, Department of Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Facial giant congenital melanocytic nevus represents a major cosmetic deformity for the child and parents and is a challenge for the plastic surgeons to achieve best cosmetic results. Herein, we present a case of single-stage surgical reconstruction using partial-thickness scalp skin graft aided with Matriderm dermal substitute for a facial giant congenital melanocytic nevus. An 8-year-old boy presented with a facial giant congenital melanocytic nevus without leptomeningeal involvement. Read More

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October 2018
4 Reads

A retrospective study of 2228 cases with eyelid tumors.

Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More

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November 2018
2 Reads

Challenges in Assessing the Sunscreen-Melanoma Association.

Int J Cancer 2018 Nov 16. Epub 2018 Nov 16.

Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.

Whether sunscreen use affects melanoma risk has been widely studied with contradictory results. To answer this question we performed a systematic review of all published studies, accounting for sources of heterogeneity and bias. We searched for original articles investigating the sunscreen-melanoma association in humans to 28. Read More

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November 2018
3 Reads

Neurocutaneous Melanosis with Leptomeningeal Melanoma Involving Supratentorium and Infratentorium.

Cureus 2018 Sep 10;10(9):e3275. Epub 2018 Sep 10.

Radiotherapy, Christian Medical College, Vellore, IND.

Neurocutaneous melanoma is a rare congenital syndrome associated with congenital melanocytic nevi with meningeal melanosis or melanoma. The disease is aggressive and has a high propensity for leptomeningeal metastases. We present the case history of a man with neurocutaneous melanoma managed with radical excision followed by hypofractionated adjuvant radiotherapy. Read More

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September 2018

Concurrent Congenital Fibrolipomatous Hamartoma and Congenital Nevus of Infancy: A Syndromic or Chance Association.

J Indian Assoc Pediatr Surg 2018 Oct-Dec;23(4):219-221

Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Congenital nevi and fibrolipomatous hamartoma are benign tumors of childhood, the latter being very uncommon. Fibrous hamartoma of infancy typically occurs in <2 years of life. The concurrence of these two lesions is extremely rare. Read More

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November 2018
1 Read

Cytoplasmic Pin1 expression is increased in human cutaneous melanoma and predicts poor prognosis.

Sci Rep 2018 Nov 15;8(1):16867. Epub 2018 Nov 15.

School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research and Center for Stress Signaling Networks, Xiamen University, Xiamen, Fujian, China.

The prolyl isomerase Pin1 is widely over-expressed or over-activated in cancers and promotes tumorigenesis. The authors investigated the expression level of Pin1 and analyzed the prognostic value of Pin1 expression using a large-scale melanoma tissue microarray study. Two independent sets of tissue microarrays were employed, including 114 melanoma cases in the discovery set and 424 in the validation set (538 cases in total), 32 normal nevi and 86 dysplastic nevi 118 cases of nevi. Read More

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November 2018

Carney Syndrome Presented as a Pathological Spine Fracture in a 35-Year-Old Male.

Am J Case Rep 2018 Nov 16;19:1366-1369. Epub 2018 Nov 16.

Fifth Surgical Clinic, Department of Surgery, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.

BACKGROUND Carney complex (CNC) is a genetic disorder that presents as an adrenocorticotropic hormone (ACTH)-independent variant of endogenous Cushing syndrome. It was first reported in 1985 and was described as a form of multiple endocrine hyperplasia associated with mutations of the c-AMP-dependent protein kinase (PRKAR1A) gene that causes bilateral adrenal hyperplasia. We report a case of an incidentally found CNC in a 35-year-old male, and this case report focuses on the diagnostic scheme as well as the surgical treatment of this rare challenging condition. Read More

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November 2018
2 Reads

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

Nat Commun 2018 11 14;9(1):4774. Epub 2018 Nov 14.

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. Read More

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November 2018
3 Reads
10.740 Impact Factor

Stathmin is a potential therapeutic target but not a prognostic marker in melanoma: an immunohistochemical study of 323 melanocytic lesions.

Melanoma Res 2018 Nov 12. Epub 2018 Nov 12.

Department of Dermatology and Venereology, First Faculty of Medicine, Charles University and General University Hospital in Prague.

In several solid tumors, an increased stathmin expression is associated with both poor prognosis and resistance to certain chemotherapy types. However, the data regarding melanocytic lesions are very limited. The goals of our study are as follows: the assessment of stathmin expression in benign and malignant melanocytic lesions, and the significance of its expression for the differential diagnostics between benign and malignant lesions; the analysis of the prognostic significance of stathmin expression in melanoma; and the evaluation of stathmin expression in melanoma and melanoma metastases with respect to possible therapeutic targeting. Read More

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November 2018
3 Reads

Dermatological manifestations in Noonan syndrome: A prospective multicentric study of 129 mutation-positive patients.

Br J Dermatol 2018 Nov 12. Epub 2018 Nov 12.

Department of Genetic Biochemistry, Robert-Debré Hospital, AP-HP and University of Paris-Diderot, Paris, France.

Background: Data on dermatological manifestations of Noonan syndrome (NS) remain heterogeneous and based on little dermatological expertise.

Objectives: To describe the dermatological manifestations of NS, compare them with the literature findings, and test for dermatological phenotype-genotype correlations with or without the presence of PTPN11 mutations.

Methods: We performed a large, 4-year, prospective, multicentric, collaborative dermatological and genetic study. Read More

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November 2018
1 Read

[Trained eye vs. gold standard].

Semergen 2018 Nov 8. Epub 2018 Nov 8.

Medicina Familiar y Comunitaria, Centro de Salud Ciudad Real I, Ciudad Real, España.

Objective: To determine the degree of correlation between the clinical diagnosis prior to the minor surgery process and its concordance with the results of histopathology report, as well as to determine the surgical data of little clinical importance compared to that which is really necessary and cost-effective.

Material And Method: A descriptive, observational, retrospective and transversal study was conducted of the Minor Surgery Activities of a clinic in the Ciudad Real Health Centre I.

Results: A total of 124 surgical specimens were sent for clinical diagnostic comparison, of which, the main clinical diagnoses were: intradermal melanocytic nevi (34. Read More

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November 2018
1 Read

Correlation of Vascular Endothelial Growth Factor subtypes and their receptors with melanoma progression: A next-generation Tissue Microarray (ngTMA) automated analysis.

PLoS One 2018 8;13(11):e0207019. Epub 2018 Nov 8.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Introduction: Finding new markers to assess prognosis of melanoma without the necessity to perform a surgical interventions is an important goal in melanoma research. The current study aimed to assess the correlation of clinical course and prognosis of primary and metastatic melanoma with expression of VEGF family and their receptors.

Methods: A ngTMA block was made from the randomly selected paraffin tissue blocks of the patients with melanocytic nevi, primary and metastatic melanoma. Read More

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November 2018
1 Read

Nevus cells of cardiofaciocutaneous syndrome bear BRAF germ-line and somatic double mutations.

Eur J Dermatol 2018 Oct;28(5):704-705

Department of Dermatology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-8543, Japan.

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October 2018
1 Read