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    Primary and Metastatic Melanoma With NTRK Fusions.
    Am J Surg Pathol 2018 Apr 20. Epub 2018 Apr 20.
    Departments of Pathology.
    A number of oncogenic driver mutations have been identified in melanocytic nevi and melanoma, but translocations also play a role in tumorigenesis and provide potential therapeutic targets for malignant lesions. Various translocations, such as those involving the anaplastic lymphoma kinase (ALK), neurotrophic tropomyosin receptor kinase 1 (NTRK1), and NTRK3 have been reported in spitzoid melanocytic neoplasms leading to kinase-fusion proteins that result in immunohistochemically detectable ALK or NTRK expression. We have previously reported that ALK expression can be found in nonspitzoid primary and metastatic cutaneous melanomas. Read More

    Clinical features and prognosis of Asian patients with acral lentiginous melanoma who have nodal nevi in their sentinel lymph node biopsy specimen.
    J Am Acad Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Dermatology, College of Medicine, Dong-A University. Electronic address:
    Background: Nodal melanocytic nevi (NN) encountered during sentinel lymph node biopsy (SLB) for malignant melanoma are usually difficult to distinguish from metastatic melanoma. However, NN have not been studied well in acral lentiginous melanoma (ALM) in Asian populations.

    Objective: To investigate the clinical characteristics and significance of NN in SLBs from ALM patients. Read More

    Oncocytic Metaplasia in Melanocytic Tumors.
    Am J Dermatopathol 2018 Apr 17. Epub 2018 Apr 17.
    Clinical Pathology Associates, Austin, TX.
    Oncocytic metaplasia represents a histopathologic feature that can be observed in normal tissue such as salivary and lacrimal glands but may also constitute a degenerative metaplastic process as a result of repeated oxidative damage during cellular aging. Although cutaneous oncocytic metaplasia has been considered rare, the finding was seen in over one-third of melanocytic nevi prospectively evaluated, in one study. This case series reports on a small series of oncocytic melanocytic tumors, with the aim of describing this phenomenon in varied contexts and also describing the use of a mitochondrial antigen immunostain, which has not been previously reported. Read More

    Pilot study on the correlation between dermoscopic patterns and fluorescence in situ hybridization findings using whole-slide digital imaging for acral volar melanocytic lesions.
    J Dermatol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Dermatology, Saitama Medical University, Irumagun, Japan.
    Dermoscopic evaluation of acral volar skin is helpful in differentiating malignant melanomas (MM) from benign melanocytic nevi. However, histological diagnosis remains difficult because sufficient evidence of histopathological changes to establish a diagnosis of MM are not easily obtained. The aim of the present study was to evaluate the effective use of fluorescence in situ hybridization (FISH) in the diagnosis of acral volar melanocytic lesions, and to determine whether acral volar melanocytic lesions show characteristic molecular biological features of malignant melanoma via FISH. Read More

    Vitiligo type cutaneous manifestation of chronic graft-versus-host disease. Case report.
    Rev Chil Pediatr 2018 Feb;89(1):113-117
    Departamento de Anatomía Patológica, Hospital Dr. Luis Calvo Mackenna, Santiago, Chile.
    Introduction: Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation. Read More

    Improving classification of melanocytic nevi: BRAF V600E expression associated with distinct histomorphologic features.
    J Am Acad Dermatol 2018 Apr 10. Epub 2018 Apr 10.
    Dermatology, University of California, Davis, Sacramento, CA 95816; Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95816.
    Background: A subset of melanomas carrying a BRAF V600E mutation, the most common targetable mutation in melanoma, arises in association with a melanocytic nevus also harboring a BRAF V600E mutation. The detailed histomorphologic characteristics of BRAF V600E-positive nevi are not systematically documented.

    Objective: To identify histomorphologic features correlating with BRAF V600E status in nevi. Read More

    Melanocytic Myxoid Spindle Cell Tumor With ALK Rearrangement (MMySTAR): Report of 4 Cases of a Nevus Variant With Potential Diagnostic Challenge.
    Am J Surg Pathol 2018 May;42(5):595-603
    Departement of Biopathology, Centre Leon Bérard, Lyon.
    Melanocytic tumors rarely display extensive dermal myxoid deposits except in the myxoid variant of melanoma. We describe in 4 patients the unusual association of morphologic and genetic features. All cases occurred in males and were located on the limbs or proximal girdle area. Read More

    Dermoscopic features of melanocytic skin lesions in Greek children and adolescents and their association with environmental factors and skin types.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece.
    Background: Acquired nevi often present in childhood and increase in number and size during early and middle life. As nevi represent potential mimickers off melanoma, the knowledge of their epidemiologic and morphologic characteristics, is essential.

    Objective: In this study, we intend to determine the prevalence of dermoscopic patterns of nevi, as well their association with environmental and constitutional factors. Read More

    Clinical and dermoscopic characteristics of congenital melanocytic nevi.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    1st Department of Dermatology - Venereology, "Andreas Sygros" University Hospital, Athens, Greece.
    Material And Methods: All children with congenital nevi (CN) attending our Pediatric Pigmented Skin lesion Unit during a 2 year period were included in the study. Clinical data were collected and all children underwent clinical and dermoscopic examination. Dermoscopic patterns and specific features were recorded. Read More

    Two cases of discrete adenoid pseudogland formation within benign intradermal melanocytic nevi.
    J Cutan Pathol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, San Antonio Military Medical Center, San Antonio, TX.
    We report two cases of benign intradermal melanocytic nevi with discrete glandular elements and mucin deposition engendering a diagnostic dilemma. The preliminary differential included entrapment of adnexal structures, collision with an adnexal neoplasm such as adenoid cystic carcinoma, or metastatic adenocarcinoma. A colloidal iron special stain confirmed the deposition of mucin, however a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative. Read More

    Sun-protection behaviour, pubertal development and menarche: factors influencing the melanocytic nevi development. The results of a observational study on 1512 children.
    J Invest Dermatol 2018 Mar 31. Epub 2018 Mar 31.
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
    Observational studies consistently show that melanocytic nevus prevalence increases with age and that phenotypic traits are significantly associated with nevus count in children. An observational study of 1512 children and adolescents from 2010 to 2013 was conducted. Study dermatologists counted the full body, arm, and facial nevi of each participant. Read More

    Malignant Melanoma of the External Auditory Canal: A Rare Entity.
    Iran J Otorhinolaryngol 2018 Mar;30(97):107-111
    Department of Otorhinolaryngology, NEIGRIHMS, Shillong. India.
    Introduction: Although malignant melanomas (MM) are common in the head and neck region; primary malignant melanoma of the external auditory canal (EAC) is rare.

    Case Report: We present the case of a 50-year-old symptomatic man with a malignant melanoma of the external auditory canal, which clinically masqueraded as a haemangioma. The patient subsequently developed extensive loco-regional metastasis, requiring extensive surgery. Read More

    Angiomatoid and desmoplastic Spitz nevus presenting as a keloidal nodule.
    Pediatr Dermatol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Pediatrics, Section of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    Angiomatoid and desmoplastic Spitz nevi are rare histologic variants of Spitz nevi that present most frequently on the extremities of children and young adults. Although Spitz nevi are clinically heterogeneous, one presenting as a keloidal nodule has not been previously published. We present a case of an angiomatoid and desmoplastic Spitz nevus clinically akin to a keloid on an African-American teenager and describe its unique histopathologic features. Read More

    Solitary pigmented lesions in oral mucosa in Latin American children: A case series.
    Pediatr Dermatol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Pathology and Oral Medicine, School of Dentistry, Oral Medicine Clinic, Universidad de Chile, Santiago, Chile.
    Background: A variety of local and systemic processes caused exogenous and endogenous pigmentation of the oral mucosa. Solitary melanotic pigmentation is rare, hence the scarce number of studies in children and adolescents.

    Methods: Clinical and histopathologic features of 10 Latin American children with solitary pigmented lesions of the oral mucosa were reviewed. Read More

    Diagnostic accuracy of dermatofluoroscopy in cutaneous melanoma detection: Results of a prospective multicentre clinical study in 476 pigmented lesions.
    Br J Dermatol 2018 Mar 22. Epub 2018 Mar 22.
    Department of Dermatology, University of Heidelberg, Germany.
    Background: Early detection is a key factor in improving survival from melanoma. Today, the clinical diagnosis of cutaneous melanoma is mostly based on visual inspection and dermoscopy. Preclinical studies in freshly excised or paraffin-embedded tissue have shown that the melanin fluorescence spectra after stepwise two-photon excitation, a process termed dermatofluoroscopy, differ between cutaneous melanoma and melanocytic nevi. Read More

    Blue Nevi of the Ocular Surface: Clinical Characteristics, Pathologic Features, and Clinical Course.
    Ophthalmology 2018 Mar 15. Epub 2018 Mar 15.
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida. Electronic address:
    Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Read More

    Rare Variant of Agminated Spitz Nevi on a Hypopigmented Background and Segmental Distribution: Case Report and Review of Literature.
    Am J Dermatopathol 2018 Feb 27. Epub 2018 Feb 27.
    Departments of Dermatology, and.
    Spitz nevus is a type of melanocytic nevus that can arise as a solitary lesion or as multiple lesions either disseminated or agminated (grouped) in different skin backgrounds (eg, grossly normal, hyperpigmented, or hypopigmented). Agminated Spitz nevi have been rarely reported and are even rarer in a background of hypopigmented skin. We present the case of a 2-month-old girl with multiple, grouped, dome-shaped, red papules arising on a hypopigmented patch with a segmental distribution. Read More

    A Multicenter Survey: How Do Transplant Dermatologists Monitor Organ Transplant Recipients With Nevi?
    Exp Clin Transplant 2018 Mar;16(Suppl 1):198-202
    Department of Dermatology, Baskent University Faculty of Medicine, Ankara, Turkey.
    Objectives: The incidence and mortality of melanoma are increased in organ transplant recipients. Multiple acquired common and dysplastic nevi are risk factors for melanoma. A new or changing nevus may suggest melanoma. Read More

    Somatic and psychiatric comorbidities of hidradenitis suppurativa in children and adolescents.
    J Am Acad Dermatol 2018 Mar 5. Epub 2018 Mar 5.
    PEDEGO Research Unit, University of Oulu, Oulu, Finland; Department of Dermatology and Medical Research Center Oulu Oulu, Finland. Electronic address:
    Background: Hidradenitis suppurativa (HS) is associated with various somatic and psychiatric comorbidities. Data regarding comorbidities in young patients with HS are sparse.

    Objective: We analyzed both somatic and psychiatric comorbidities in young patients in a nationwide HS cohort. Read More

    [Bean's syndrome in children: about two cases].
    Pan Afr Med J 2017 4;28:102. Epub 2017 Oct 4.
    Service des Urgences Chirurgicales Pédiatriques, CHU Ibn Sina, Faculté de Médecine Mohammed V, Rabat, Maroc.
    Diffuse angiomatosis or Bean's syndrome is a rare disease characterized by venous malformations mainly involving the skin and the digestive tract which can result in hemorrhage of variable severity. This study reports the case of two children aged 5 and 9 and a half years respectively with diffuse angiomatosis who had been treated in the Department of Emergency Paediatric Surgery over the years. The diagnosis was based on rectal bleeding and/or melenas causing severe anemia requiring regular transfusions in both patients as well as skin angiomas occurrence at the level of the limbs. Read More

    Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies.
    Case Rep Dermatol 2018 Jan-Apr;10(1):24-28. Epub 2018 Feb 8.
    cDepartment of Pediatrics, Richmond University Medical Center, New York, NY, USA.
    Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Read More

    Oncogenic BRAF mutations and p16 expression in melanocytic nevi and melanoma in the Polish population.
    Postepy Dermatol Alergol 2017 Oct 31;34(5):490-498. Epub 2017 Oct 31.
    Chair of Biotechnology, Department of Cancer Immunology, Poznan University of Medical Sciences, Medical Biology Centre, Poznan, Poland.
    Introduction: Twenty-five - fifty percent of skin melanomas arise from nevi. Melanocyte proliferation is activated by , then is arrested, but single nevi transform to melanomas. p16 controls arrest, and p16 loss may promote transformation. Read More

    The Amount of Melanin Influences p16 Loss in Spitzoid Melanocytic Lesions: Correlation With CDKN2A Status by FISH and MLPA.
    Appl Immunohistochem Mol Morphol 2018 Feb 27. Epub 2018 Feb 27.
    Biomedical Research Institute INCLIVA.
    Aims: The risk assessment of spitzoid lesions is one of the most difficult challenges in dermatopathology practice. In this regard, the loss of p16 expression and the homozygous deletion of CDKN2A, have been pointed in the literature as reliable indicators of high risk. However, these findings are poorly reproducible, and the molecular bases underlying the loss of p16 expression remain unclear. Read More

    Small Dysplastic Congenital Melanocytic Nevi in Childhood as Possible Melanoma Imitators.
    Open Access Maced J Med Sci 2018 Jan 13;6(1):149-151. Epub 2018 Jan 13.
    "Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    Small pigmented lesions in children can represent a significant diagnostic challenge. If the diagnostic features and therapeutic approach are relatively well established in large and giant nevi, there is still much controversy regarding small and intermediate-sized congenital pigmented lesions that can lead to significant diagnostic challenges, both clinically and dermoscopically, and consequently to difficulty in defining the optimal approach in such cases. Although dermoscopy can be useful in the diagnosis of pigmented lesions, the diversity of clinical and dermoscopic features of pigmented nevi in children usually hinder the differentiation between them and melanoma. Read More

    Medium Sized Congenital Melanocytic Nevus with Suspected Progression to Melanoma during Pregnancy: What's the Best for the Patient?
    Open Access Maced J Med Sci 2018 Jan 13;6(1):143-145. Epub 2018 Jan 13.
    University G. Marconi of Rome - Dermatology and Venereology, Rome, Italy.
    Background: Congenital melanocytic nevi (CMN) are pigmented skin lesions usually present at birth. Rare varieties can develop and become clinically very large. Although they are benign nevomelanocytic neoplasms, all CMN may be precursors of the melanoma, regardless of their size. Read More

    Whole-Exome Sequencing of Acquired Nevi Identifies Mechanisms for Development and Maintenance of Benign Neoplasms.
    J Invest Dermatol 2018 Feb 22. Epub 2018 Feb 22.
    Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
    The melanoma transformation rate of an individual nevus is very low despite the detection of oncogenic BRAF or NRAS mutations in 100% of nevi. Acquired melanocytic nevi do, however, mimic melanoma, and approximately 30% of all melanomas arise within pre-existing nevi. Using whole-exome sequencing of 30 matched nevi, adjacent normal skin, and saliva we sought to identify the underlying genetic mechanisms for nevus development. Read More

    Multiple perineuriomatous melanocytic nevi.
    J Cutan Pathol 2018 Feb 22. Epub 2018 Feb 22.
    Department of Pathology and Laboratory Medicine, University of Auckland, Auckland, New Zealand.
    Perineuriomatous differentiation in solitary cutaneous melanocytic nevi has been described. We present an unusual case of a patient with multiple such perineuriomatous nevi. This presentation raises the possibility that a germline mutation may be responsible for the pathogenesis of these unusual lesions. Read More

    Sirolimus alternative to blood transfusion as a life saver in blue rubber bleb nevus syndrome: A case report.
    Medicine (Baltimore) 2018 Feb;97(8):e9453
    Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
    Rationale: Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterized by multiple venous malformations. The gastrointestinal bleeding and secondary iron deficiency anemia are the most common complications. There are currently no effective treatments for BRBNS. Read More

    Unclassified sclerosing malignant melanomas with AKAP9-BRAF gene fusion: a report of two cases and review of BRAF fusions in melanocytic tumors.
    Virchows Arch 2018 Mar 21;472(3):469-476. Epub 2018 Feb 21.
    Département de Biopathologie, Centre Leon Bérard, Lyon, France.
    The current classification of melanocytic tumors includes clinical, pathological, and molecular data. A subset of lesions remains difficult to classify according to these complex multilayer schemes. We report two cases of deeply infiltrating melanomas with a sclerosing background. Read More

    Eruptive nevi after burn injury.
    Dermatol Pract Concept 2018 Jan 31;8(1):66-67. Epub 2018 Jan 31.
    Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.
    Eruptive melanocytic nevi (EMN) is an unusual phenomenon characterized by the abrupt development of multiple melanocytic nevi over weeks to months in association with an underlying trigger. The underlying mechanisms are not fully understood, however, they have been associated with a variety of conditions. EMN is relatively uncommon and might be underreported due to the absence of close monitoring, insufficient recognition, and the presumed benign course of the condition. Read More

    Conjunctival melanocytic naevus: Diagnostic value of anterior segment optical coherence tomography and ultrasound biomicroscopy.
    PLoS One 2018 14;13(2):e0192908. Epub 2018 Feb 14.
    University of Szeged, Department of Ophthalmology, Szeged, Hungary.
    Purpose: Conjunctival naevi are the most frequently diagnosed primary melanocytic lesions of the conjunctiva. The clinical manifestations are greatly variable which may result in diagnostic difficulties and differential diagnostic confusions. Therefore aims of the present study were: 1) to assess the morphologic features of conjunctival naevi; 2) to delineate the anterior segment optical coherence tomography (AS-OCT) characteristics of these lesions; 3) to compare AS-OCT and ultrasound biomicroscopy (UBM) as diagnostic tools in these alterations and 4) to correlate histological results with the AS-OCT pictures in case of surgically excised naevi. Read More

    Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.
    Cancer Cell 2018 Feb;33(2):322-336.e8
    Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, 13353 Berlin, Germany; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Germany.
    Oncogene-induced senescence, e.g., in melanocytic nevi, terminates the expansion of pre-malignant cells via transcriptional silencing of proliferation-related genes due to decoration of their promoters with repressive trimethylated histone H3 lysine 9 (H3K9) marks. Read More

    Treatment of flat and elevated pigmented disorders with a 755-nm alexandrite picosecond laser: clinical and histological evaluation.
    Lasers Med Sci 2018 Feb 9. Epub 2018 Feb 9.
    Dermatology Department, Laser Unit, Hospital Universitario Ramón y Cajal, Ctra Colmenar Viejo Km 9,100, 28034, Madrid, Spain.
    The novel picosecond lasers, initially developed for faster tattoo removal, have also shown great efficacy in endogenous pigmentary disorders. To describe the efficacy and safety profile of an alexandrite (755-nm) picosecond laser in a wide range of pigmented flat and elevated cutaneous lesions. A retrospective study was performed in which we collected all the clinical images of patients treated with the 755-nm alexandrite picosecond laser for 12 months (November 2016-November 2017). Read More

    CKS1 expression in melanocytic nevi and melanoma.
    Oncotarget 2018 Jan 23;9(3):4173-4187. Epub 2017 Dec 23.
    Department of Pathology and Laboratory Medicine, Albany Medical College MC-81, Albany, NY 12208, USA.
    Cyclin-dependent kinase subunit 1 (Cks1) regulates the degradation of p27, an important G1-S inhibitor, which is up regulated by MAPK pathway activation. In this study, we sought to determine whether Cks1 expression is increased in melanocytic tumors and correlates with outcome and/or other clinicopathologic prognostic markers. Cks1 expression was assessed by immunohistochemistry in 298 melanocytic lesions. Read More

    Lacrimal Caruncle Nevus with Papilloma.
    Case Rep Ophthalmol 2017 Sep-Dec;8(3):535-538. Epub 2017 Dec 5.
    Department of Oculoplastic, Orbital and Lacrimal Surgery, Aichi Medical University Hospital, Nagakute, Japan.
    Purpose: The aim of this article is to report a case of lacrimal caruncle nevus with papilloma.

    Methods: This is a case report of a 39-year-old female with a progressively enlarging pigmented lesion on the left lacrimal caruncle. She had been aware of a raised whitish wart on the top of this pigmented lesion for several months before her initial visit. Read More

    Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma.
    Arch Dermatol Res 2018 Feb 7. Epub 2018 Feb 7.
    Department of Dermatology, Venereology and Allergology, HELIOS-Klinikum Hildesheim, Senator-Braun-Allee 33, 31135, Hildesheim, Germany.
    The histopathologic differentiation between Spitz nevus and melanoma is of particular interest in routine diagnostic procedures of melanocytic tumors. Atypical Spitz nevi are sometimes difficult to distinguish from melanoma. There is still no single criterion that ensures a distinction of melanoma and atypical Spitz nevus. Read More

    No BRAF V600E Mutation Identified in 28 Periocular Pyogenic Granuloma.
    Ophthal Plast Reconstr Surg 2018 Feb 5. Epub 2018 Feb 5.
    Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
    Purpose: BRAF V600E mutations were recently identified in some pyogenic granulomas of skin, particularly lesions arising in patients with port wine stains. In this study, the authors analyzed BRAF gene status in 28 periocular pyogenic granulomas to determine its role in their pathogenesis.

    Methods: Retrospective review of ophthalmic pathology archives from 2007 to 2016 was used to identify pyogenic granulomas of the conjunctiva, eyelid, and orbit. Read More

    Benign and malignant collision tumors of melanocytic skin lesions with hemangioma: Dermoscopic and reflectance confocal microscopy features.
    Skin Res Technol 2018 May 31;24(2):313-317. Epub 2018 Jan 31.
    Division of Dermatology - Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena, Italy.
    Background: Though the combination/collision of nevi or lentigo simplex and hemangiomas is frequent, the malignant collision tumor melanoma-hemangioma is exceptional and can sometime clinically simulate a benign collision. To date, a series of collision tumors of hemangiomas associated with either benign or malignant melanocytic skin lesions (MSL) has yet to be studied by non-invasive imaging and clinico-pathologic correlates.

    Methods: We present 10 cases of patients with collision tumors of hemangioma with different MSL including: 2 in situ lentigo-maligna melanoma, 1 invasive melanoma, 5 melanocytic nevi, and 2 lentigo simplex. Read More

    A quantitative comparison between SOX10 and MART-1 immunostaining to detect melanocytic hyperplasia in chronically sun-damaged skin.
    J Cutan Pathol 2018 Apr 15;45(4):263-268. Epub 2018 Feb 15.
    Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut.
    Histologic differentiation of melanoma in situ (MIS) from solar keratosis on chronically sun-damaged skin is challenging. The first-line immunostain is usually MART-1/Melan-A, which can exaggerate the epidermal melanocytes, causing a diagnostic pitfall for MIS. By comparing MART-1 and SOX10 immunostaining, we scored the percentage of epidermal melanocytes per 2-mm diameter fields in pigmented actinic keratosis (n = 16), lichenoid keratosis (n = 7), junctional melanocytic nevus (n = 6), keratosis with atypical melanocytic proliferation (n = 17) and MIS (n = 10). Read More

    Genetic Background of Iris Melanomas and Iris Melanocytic Tumors of Uncertain Malignant Potential.
    Ophthalmology 2018 Jan 19. Epub 2018 Jan 19.
    Department of Ocular Oncology, The Rotterdam Eye Hospital, Rotterdam, The Netherlands; Department of Pathology, Section Ophthalmic Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:
    Purpose: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Iris melanoma comprises 4% to 10% of all UMs and has a lower mortality rate. The genetic changes in iris melanoma are not as well characterized as ciliary body or choroidal melanoma. Read More

    An alternative strategy treated giant congenital melanocytic nevi with epidermis and superficial dermis of the lesions.
    Medicine (Baltimore) 2018 Jan;97(4):e9725
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Giant congenital melanocytic nevi (GCMN) are defined as rare pigmented lesions that are believed to form between weeks 9 and 20 of gestation. It is difficult to reconstruct large defects after the removal of the lesions and it has posed a great challenge to the plastic surgeon and dermatologist.Given all those difficulty reconstructing the defects, we try to explore an alternative way to resurfacing the defect after removal of GCMN. Read More

    Clinical profile of 300 men with facial hypermelanosis.
    J Dermatol Case Rep 2017 Dec 1;11(2):20-24. Epub 2017 Dec 1.
    Department of Dermatology, Venereology & Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda)-176001 (Himachal Pradesh), India.
    Background: Facial hypermelanosis is a significant cause of cosmetic disfigurement, social embarrassment and psychological morbidity affecting quality of life.

    Objective: To study clinicoepidemlogic patterns of facial hypermelanoses among men.

    Material And Methods: Medical records of all adult males presenting with facial hypermelanoses were analyzed for this retrospective cross sectional study for demographic details, duration, cosmetic usage, sun exposure, drug intake, infections, systemic or cutaneous diseases, and family history of hypermelanotic dermatosis. Read More

    A Case of Adenocarcinoma of the Retinal Pigment Epithelium: An Immunohistochemical and Electron Microscopic Study.
    Ocul Oncol Pathol 2017 Dec 19;4(1):38-43. Epub 2017 Jul 19.
    Department of Ophthalmology, Kansai Medical University, Osaka, Japan.
    Purpose: Retinal pigment epithelium (RPE) adenocarcinoma is a very rare malignant intraocular tumor. Herein we describe the histopathological features of RPE adenocarcinoma.

    Case: A 36-year-old male was referred to our clinic because of floaters in his left eye. Read More

    Histological features and outcome of inverted type-A melanocytic nevi.
    J Cutan Pathol 2018 Apr 13;45(4):254-262. Epub 2018 Feb 13.
    Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.
    The presence of enlarged epithelioid/spindled nests located deep in the reticular dermis of a biphasic melanocytic neoplasm can mimic melanoma arising in a pre-existing nevus, causing over-interpretation of malignancy. We aimed to define the clinicopathologic significance of epithelioid/spindled nests in melanocytic nevi. Retrospectively using clinical and histologic information, we characterized 121 patients with a single lesion showing epithelioid/spindled melanocytes in the reticular dermis or subcutaneous fat, surrounded by melanophages, sometimes blending in with the adnexa. Read More

    [Phakomatosis pigmentovascularis cesioflammea: a case report].
    Arch Argent Pediatr 2018 Feb;116(1):e121-e124
    Servicio de Dermatología, Hospital Nacional de Pediatría "Prof. Dr. J. P. Garrahan", Ciudad Autónoma de Buenos Aires.
    Phakomatosis pigmentovascularis (PPV) is a syndrome characterized by the association of a vascular nevus with a congenital pigmented lesion (epidermal nevus, nevus spilus, and dermal melanocytosis). There are different types of PPV according to the pigmentary nevus associated with the vascular malformation. Patients may present only the cutaneous condition or have systemic manifestations, among them, trauma, neurological and ophthalmological disorders. Read More

    BRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi.
    Invest Ophthalmol Vis Sci 2018 Jan;59(1):117-121
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, United States.
    Purpose: To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi.

    Methods: Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. Read More

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