Pigment Cell Melanoma Res 2022 May 8. Epub 2022 May 8.
Department of Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Background: Epidermal melanocytes sense solar light via the opsin-coupled signaling pathway which is involved in a range of biological functions, including regulating pigmentation, proliferation, apoptosis, and tumorigenesis. However, it remains unclear whether there are genetic variants within these opsins that affect opsin protein structure and function, and further melanocyte biological behaviors.
Methods: Here, we examined single nucleotide variants (SNVs) of five opsin (RGR, OPN1SW, OPN2, OPN4, and OPN5) genes in MM (malignant melanoma) (n=76) and MN (melanocytic nevi) (n=157), using next-generation sequencing. Read More