11,321 results match your criteria Nevi Melanocytic


Silencing of microRNA-27a facilitates autophagy and apoptosis of melanoma cells through the activation of the SYK-dependent mTOR signaling pathway.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, P.R. China.

Melanoma is considered as an aggressive neoplastic transformation and featured with high metastatic potential. Although some studies have provided targets for novel therapeutic interventions, clinical development of targeted drugs for melanoma still remains obscure. Therefore, this study aims to identify the role of microRNA-27a (miR-27a) in autophagy and apoptosis of melanoma cells in regulating spleen tyrosine kinase (SYK)-mediated the mammalian target of rapamycin (mTOR) signaling pathway. Read More

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http://dx.doi.org/10.1002/jcb.28600DOI Listing

Sparing of the nipple-areola complex by capillary malformations: Vascular variant of the Bork-Baykal phenomenon.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, University Children's Hospital Niño Jesús, Madrid, Spain.

The"Bork-Baykal phenomenon" refers to the sparing of the nipple-areola complex in large congenital melanocytic nevi involving the breast. So far, this finding has not been reported in vascular anomalies. We present four patients with an extensive capillary malformation (CM) involving the breast that was found to exhibit a similar sparing of the nipple and areola. Read More

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http://dx.doi.org/10.1111/pde.13844DOI Listing

Tattoo pigment removal by halo nevus phenomenon.

JAAD Case Rep 2019 Apr 30;5(4):317-318. Epub 2019 Mar 30.

Metrohealth Medical Center and Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2018.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441708PMC

External validation and comparison of four confocal microscopic scores for melanoma diagnosis on a retrospective series of highly suspicious melanocytic lesions.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Italy.

Background: In-vivo reflectance confocal microscopy significantly improves melanoma diagnosis as compared to clinical/dermoscopic examination alone. Several confocal criteria have been described allowing to differentiate melanoma from nevi; by combining different criteria three pure confocal scores (Pellacani 2005, Segura 2009 and Pellacani 2012) and one mixed dermoscopic/confocal score (Borsari 2018) were constructed.

Objective: Our aim was to externally validate and compare the performance of these confocal scores. Read More

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http://dx.doi.org/10.1111/jdv.15617DOI Listing
April 2019
1 Read

Distinguishing melanocytic nevi from melanomas using static and dynamic infrared thermal imaging.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

LABIOMEP, INEGI-LAETA, Faculdade de Engenharia, Universidade do Porto.

Background: The incidence rates of melanoma have risen to worrying levels over the last decade. Delayed diagnosis, due to faults on the detection stage, indicate the necessity of new aiding diagnosis techniques. Since metabolic activity is highly connected to neoplasia formation, a detection technique that focus its results on vascular responses, as IRT, seems to be a viable option. Read More

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http://dx.doi.org/10.1111/jdv.15611DOI Listing
April 2019
1 Read

Cosmetically Challenging Congenital Melanocytic Nevi.

Ann Plast Surg 2019 May;82(5S Suppl 4):S306-S309

Division of Plastic and Reconstructive Surgery, Cedar-Sinai, Los Angeles, CA.

Background: Congenital melanocytic nevi (CMN) have a 1% to 5% lifetime risk for malignant transformation, with 50% of transformations occurring before the age of 5 years.The aim of this study is to assess the risk of melanoma development in pediatric patients with facial CMN involving the eyebrows, eyelid margins, and nasal alae where a margin of CMN was not excised to preserve these structures.

Methods: A retrospective chart review of all pediatric patients with CMN from 1986 to 2014 was performed to review demographic information, diagnosis, and number of surgeries. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001766DOI Listing

Validation of Whole-slide Digitally Imaged Melanocytic Lesions: Does Z-Stack Scanning Improve Diagnostic Accuracy?

J Pathol Inform 2019 21;10. Epub 2019 Feb 21.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Accurate diagnosis of melanocytic lesions is challenging, even for expert pathologists. Nowadays, whole-slide imaging (WSI) is used for routine clinical pathology diagnosis in several laboratories. One of the limitations of WSI, as it is most often used, is the lack of a multiplanar focusing option. Read More

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http://dx.doi.org/10.4103/jpi.jpi_46_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415522PMC
February 2019
1 Read

Predictors of Health-related Quality of Life and Psychological Adjustment in Children and Adolescents With Congenital Melanocytic Nevi: Analysis of Parent Reports.

J Pediatr Psychol 2019 Mar 26. Epub 2019 Mar 26.

Department of Psychosomatics and Psychiatry, and Children's Research Center, University Children's Hospital.

Objectives: This cross-sectional study assessed health-related quality of life (HRQOL) and psychological adjustment in children and adolescents affected by congenital melanocytic nevi (CMN) and identified potential predictors of adjustment.

Methods: Participants were recruited worldwide with the help of patient organizations. Data were obtained from parents of 235 children affected by CMN, aged between 1 month and 18 years (M = 6. Read More

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http://dx.doi.org/10.1093/jpepsy/jsz017DOI Listing
March 2019
1 Read

Clinical and dermoscopic (in vivo and ex vivo) predictors of recurrent nevi.

Eur J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Recurrent nevi occur following removal of melanocytic nevi mainly after shaving excision. Due to its differential diagnosis with melanoma, its recognition can be challenging. To evaluate clinical and dermoscopic predictors of recurrent nevi. Read More

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http://dx.doi.org/10.1684/ejd.2019.3530DOI Listing
March 2019
1 Read

Large-Giant Congenital Melanocytic Nevi: Moving Beyond NRAS Mutations.

Authors:
Mitchell S Stark

J Invest Dermatol 2019 Apr;139(4):756-759

Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia. Electronic address:

Large-giant congenital melanocytic nevi have been well characterized clinically, yet questions remain about the heterogenous phenotypes observed. Martins da Silva et al. (2018) highlight the genotypic diversity between "classic" and "spilus-like" congenital melanocytic nevi by analyzing multiple biopsy sites and matching satellite nevi. Read More

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http://dx.doi.org/10.1016/j.jid.2018.10.003DOI Listing

A Man with Juvenile Nasopharyngeal Angiofibroma, Vestibular Schwannoma, Cleft Lip and Cleft Palate, and Various Nevi: Case Report and Review.

Cureus 2018 Sep 14;10(9):e3304. Epub 2018 Sep 14.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Juvenile nasopharyngeal angiofibroma is a vascular tumor that typically occurs in men. Vestibular schwannoma (acoustic neuroma) is a tumor affecting the vestibulocochlear nerve. A 38-year-old man with various pigmented lesions and history of juvenile nasopharyngeal angiofibroma, vestibular schwannoma, and cleft lip and cleft palate is described. Read More

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http://dx.doi.org/10.7759/cureus.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417465PMC
September 2018
1 Read

Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.

Pediatr Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York City, New York.

Neurocutaneous melanosis (NCM) is the condition of abnormal melanocyte deposition in the leptomeninges and brain parenchyma. Associated with congenital melanocytic nevi, NCM can result in neurologic deficits, hydrocephalus, and rarely, malignant transformation of cells. We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor. Read More

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http://dx.doi.org/10.1111/pde.13804DOI Listing
March 2019
4 Reads

Clinical and Histopathologic Characteristics of Melanocytic Lesions on the Volar Skin Without Typical Dermoscopic Patterns.

JAMA Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

Importance: It is challenging to differentiate melanoma from melanocytic nevus on the volar skin in the absence of typical dermoscopic patterns.

Objective: To identify the frequency and clinical and dermoscopic characteristics of melanocytic lesions on the volar skin not displaying a parallel furrow pattern, lattice-like pattern, fibrillar pattern, or parallel ridge pattern on results of dermoscopy.

Design, Setting, And Participants: In this retrospective cohort study, a total of 504 melanocytic lesions on the volar skin were evaluated in the Shinshu University Hospital department of dermatology between January 1, 2000, and December 31, 2012. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.5926DOI Listing
March 2019
1 Read

A case of woolly hair nevus, multiple linear pigmentation, and epidermal nevi with somatic HRAS p.G12S mutation.

Pediatr Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Woolly hair nevus is a rare syndrome that presents as woolly hair in restricted areas of the scalp and may be associated with pigmented macules or epidermal nevus on the body. Here, we report a case of woolly hair nevus, linear pigmentation, and multiple epidermal nevi with a somatic HRAS c.34G>A(p. Read More

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http://dx.doi.org/10.1111/pde.13783DOI Listing

Evolution of congenital melanocytic nevi toward benignity: A case series.

Pediatr Dermatol 2019 Mar 6;36(2):227-231. Epub 2019 Mar 6.

Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona.

We report on four children born with medium to large congenital melanocytic nevi (CMN) with color heterogeneity and irregular surface rugosity. As these patients aged, their nevi evolved to become more homogeneous and lighter in color, and developed a smoother, more even texture. We propose that given this evolution toward benignity, conservative monitoring and management may be appropriate even in the context of atypical-appearing features at birth. Read More

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http://dx.doi.org/10.1111/pde.13745DOI Listing
March 2019
1 Read

Nuclear morphometric analysis in tissue as an objective tool with potential use to improve melanoma staging.

Melanoma Res 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathology Federal University of Health Sciences of Porto Alegre, Porto Alegre.

Alterations in nuclear size and shape are commonly observed in cancers, and its objective evaluation may provide valuable clinical information about the outcome of the disease. Here, we applied the nuclear morphometric analysis in tissues in hematoxylin and eosin-digitized slides of nevi and melanoma, to objectively contribute to the prognostic evaluation of these tumors. To this, we analyzed the nuclear morphometry of 34 melanomas classified according to the TNM stage. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000594DOI Listing
March 2019
1 Read

[Clinicopathological features and prognosis of ALK-positive Spitz tumors].

Zhonghua Bing Li Xue Za Zhi 2019 Mar;48(3):215-219

Clinical Pathological Diagnosis Center of Fudan University, Shanghai 200032, China.

To investigate the clinicopathologic features and prognosis of ALK-positive Spitz tumors. Thirteen patients with ALK-positive Spitz tumors diagnosed at Shanghai Cancer Center, Fudan University from October 2016 to December 2017 were collected. All cases were routinely evaluated histopathological features in HE staining and detected ALK protein expression by immunohistochemistry. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.03.009DOI Listing
March 2019
10 Reads

Combination laser therapy as a non-surgical method for treating congenital melanocytic nevi from cosmetically sensitive locations on the body.

Lasers Med Sci 2019 Feb 28. Epub 2019 Feb 28.

Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.

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http://dx.doi.org/10.1007/s10103-019-02753-0DOI Listing
February 2019
1 Read

Perinevoid Alopecia: A Case Report.

Skin Appendage Disord 2019 Feb 18;5(2):94-96. Epub 2018 Jul 18.

Department of Dermatopathology, "Dr. Manuel Gea González" General Hospital, Mexico City, Mexico.

Perinevoid alopecia has been described as an associated alopecia surrounding a pigmented nevus due to an inflammatory response against nevus structures. It is described as a part of other nevocentric phenomena in which a cellular inflammatory response against nevus antigens develops. A 35-year-old male presented with a unique area of non-scarring alopecia surrounding an asymptomatic, pigmented nevus with a 1-month evolution. Read More

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http://dx.doi.org/10.1159/000490469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388562PMC
February 2019
2 Reads

Invasive melanoma in a 5-year-old Canadian patient: A case report.

SAGE Open Med Case Rep 2019 18;7:2050313X19829630. Epub 2019 Feb 18.

Division of Dermatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Atypical Spitzoid lesions pose a distinct challenge in classification as they may comprise a mixture of both classic benign nevus and cutaneous melanoma characteristics. Immunostaining and molecular analysis, such as comparative genomic hybridization, can assist in narrowing the differential diagnosis. We present a case of a 5-year-old male with an atypical Spitzoid lesion on his back. Read More

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http://dx.doi.org/10.1177/2050313X19829630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381421PMC
February 2019
2 Reads

Pine tar callus: A mimicker of a melanocytic lesion.

Pediatr Dermatol 2019 Feb 27. Epub 2019 Feb 27.

Northwestern University Feinberg School of Medicine, Chicago, Illinois.

We report a case of acral pigmented lesions due to pine tar, a common compound used on baseball bats to improve grip, deposition. The patient presented with an acute concern for a new melanocytic lesion, and dermoscopy revealed large brown globules, not typical of melanocytic neoplasms. We propose that the coupling of dermoscopy and a thorough clinical history of exogenous exposures in similar clinical presentations can provide reassurance in evaluating atypical appearing pigmented lesions. Read More

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http://dx.doi.org/10.1111/pde.13773DOI Listing
February 2019
1 Read

Digitally reconstructed top-down view images provides intuitive understanding of correlation between dermoscopy and histopathology: A good educational tool.

Br J Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-Ku, Hamamatsu, 431-3192, Japan.

Dermoscopy is an optical technique, which enables us to observe the fine structures especially in melanocytic skin lesions. In the dermoscopic structures of melanocytic lesions, including nevocellular nevus and melanoma, 1) pigment network, 2) dots and globules, and 3) streaks are main components. The irregularity of these structures helps us differentiate benign nevi from malignant melanoma. Read More

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http://dx.doi.org/10.1111/bjd.17819DOI Listing
February 2019
1 Read

Neurocutaneous Melanosis in Association With Large Congenital Melanocytic Nevi in Children: A Report of 2 Cases With Clinical, Radiological, and Pathogenetic Evaluation.

Front Neurol 2019 7;10:79. Epub 2019 Feb 7.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Melanocytic nevi present at birth, or within the first few months of life, are defined as congenital melanocytic nevi (CMN). Neurocutaneous melanosis (NCM) is a rare disorder, represents pigment cell tumors of the leptomeninges, and occurs in association with large or multiple CMN. NCM carries an extremely poor prognosis. Read More

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http://dx.doi.org/10.3389/fneur.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374324PMC
February 2019
2 Reads

Giant Congenital Melanocytic Nevus Treated With Trametinib.

Pediatrics 2019 Mar;143(3)

Division of Pediatric Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas

Giant congenital nevi are melanocytic proliferations of the skin that may be complicated by melanoma, neurocutaneous melanocytosis, pain, pruritus, and disfigurement. Current treatment options include surgical resection and medical management of associated symptoms. There is limited efficacy in these modalities. Read More

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http://dx.doi.org/10.1542/peds.2018-2469DOI Listing
March 2019
2 Reads

Isolated straight hair nevus in a White child.

Pediatr Dermatol 2019 Mar 21;36(2):260-261. Epub 2019 Feb 21.

Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin Diseases, INSERM U 1035, University of Bordeaux, Bordeaux, France.

We report a 6-month-old girl born with a fronto-parietal patch of hair straighter than the remainder of the scalp hairs. We took a biopsy to rule out a congenital melanocytic nevus. We concluded after additional scanning electron microscopy study of the hair shafts that the lesion corresponds to a possible local mosaicism causing an isolated straight hair nevus phenotype. Read More

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http://dx.doi.org/10.1111/pde.13740DOI Listing
March 2019
2 Reads

Massively Parallel Sequencing Analysis of Benign Melanocytic Nevi.

Histopathology 2019 Feb 21. Epub 2019 Feb 21.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Aims: Melanocytic nevi are benign lesions of the skin or mucosa, which may constitute non-obligate precursors of malignant melanoma, particularly when displaying lentiginous and dysplastic features. Here we sought to interrogate the repertoire of somatic genetic alterations in melanocytic nevi.

Methods And Results: DNA extracted from 12 melanocytic nevi and matching normal tissue were separately microdissected and subjected to targeted massively parallel sequencing targeting ≥300 cancer genes. Read More

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http://dx.doi.org/10.1111/his.13843DOI Listing
February 2019
1 Read

[Clinico-echographic diagnostics of iris tumors].

Ophthalmologe 2019 Apr;116(4):313-323

Zentrum für Augenheilkunde, Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: The differentiation of iridic space-occupying lesions represents a regularly reoccurring diagnostic challenge.

Objective: This article presents an overview of the epidemiological data and describes the diagnostic procedure for iris tumors.

Material And Methods: The article provides a review of the literature from PubMed and own clinical results. Read More

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http://dx.doi.org/10.1007/s00347-019-0861-yDOI Listing
April 2019
2 Reads

Molecular genomic profiling of melanocytic nevi.

J Invest Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Melanoma Institute Australia, The University of Sydney, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

The benign melanocytic nevus is the commonest tumor in humans and rarely transforms into cutaneous melanoma. Elucidation of the nevus genome is required to better understand the molecular steps of progression to melanoma. We performed whole genome sequencing on a series of 14 benign melanocytic nevi, consisting of both congenital and acquired types. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193011
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http://dx.doi.org/10.1016/j.jid.2018.12.033DOI Listing
February 2019
18 Reads

Acanthosis nigricans, hypochondroplasia, and FGFR3 mutations: Findings with five new patients, and a review of the literature.

Pediatr Dermatol 2019 Mar 14;36(2):242-246. Epub 2019 Feb 14.

Department of Dermatology, CHU Nantes, Nantes, France.

Early development of extensive acanthosis nigricans (AN) is a key feature in some patients who have hypochondroplasia (HCH) in association with FGFR3 mutations. We here report regarding five new patients with HCH who exhibited AN, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the AN lesions began in childhood, and they were extensive. Read More

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http://dx.doi.org/10.1111/pde.13748DOI Listing
March 2019
1 Read

Lasers for Becker's nevus.

Lasers Med Sci 2019 Feb 14. Epub 2019 Feb 14.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.

Becker's nevus is a common pigmented dermatosis, usually featured by ipsilateral pigmented patch with hypertrichosis. Becker's nevus is often treated with various types of lasers although other regimens are available. However, clinical outcomes appear inconsistent among studies. Read More

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http://dx.doi.org/10.1007/s10103-019-02734-3DOI Listing
February 2019
12 Reads

β-Catenin nuclear expression discriminates deep penetrating nevi from other cutaneous melanocytic tumors.

Virchows Arch 2019 Feb 12. Epub 2019 Feb 12.

Departement de Biopathologie, Centre Léon Bérard, 28, rue Laennec, 69008, Lyon, France.

Recent advances in genomics have improved the molecular classification of cutaneous melanocytic tumors. Among them, deep penetrating nevi (DPN) and plexiform nevi have been linked to joint activation of the MAP kinase and dysregulation of the β-catenin pathways. Immunohistochemical studies have confirmed cytoplasmic and nuclear expression of β-catenin and its downstream effector cyclin D1 in these tumors. Read More

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http://dx.doi.org/10.1007/s00428-019-02533-9DOI Listing
February 2019
16 Reads

[The application of modified rhomboid flap in repairing facial skin and soft tissue defect].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 02;33(2):207-211

Department of Plastic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P.R.China.

Objective: To explore the effectiveness of modified rhomboid flap for repairing facial skin and soft tissue defect.

Methods: Between January 2016 and May 2018, 23 patients with facial skin and soft defect were repaired by the modified rhomboid flap. There were 10 males and 13 females with the median age of 27 years (range, 11-72 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201810020
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http://dx.doi.org/10.7507/1002-1892.201810020DOI Listing
February 2019
3 Reads

A cellular blue nevus with pigmented epithelioid melanocytoma-like pattern on the ipsilateral upper arm associated with a congenital plaque-type blue nevus on the hand.

J Cutan Pathol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A 36-year-old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Read More

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http://dx.doi.org/10.1111/cup.13435DOI Listing
February 2019
1 Read

Involvement of circulatory disturbance in optic disk melanocytoma with visual dysfunction.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 4;257(4):835-841. Epub 2019 Feb 4.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Purpose: This study aims to examine the relationship between ocular circulation changes and visual field defects in optic disk melanocytoma (ODM).

Methods: Five eyes of five patients were enrolled in this study. All patients were diagnosed with ODM in the Department of Ophthalmology, Hokkaido University Hospital from March 2009 to November 2017. Read More

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http://dx.doi.org/10.1007/s00417-019-04257-7DOI Listing

Extremity nevus count is an independent risk factor for basal cell carcinoma and melanoma, but not squamous cell carcinoma.

J Am Acad Dermatol 2019 Apr 31;80(4):970-978. Epub 2019 Jan 31.

Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana; Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana. Electronic address:

Background: The presence of nevi portends an increased risk for melanoma.

Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers.

Methods: We evaluated prospective cohorts of 176,317 women (the Nurses' Health Study, 1986-2012 and the Nurses' Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183265
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http://dx.doi.org/10.1016/j.jaad.2018.09.044DOI Listing
April 2019
11 Reads

Black and Brown Oro-facial Mucocutaneous Neoplasms.

Authors:
Easwar Natarajan

Head Neck Pathol 2019 Mar 29;13(1):56-70. Epub 2019 Jan 29.

Section of Oral and Maxillofacial Pathology, University of Connecticut Health Center, 263 Farmington Ave, MC-0925, Farmington, CT, 06030, USA.

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. Read More

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http://dx.doi.org/10.1007/s12105-019-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406009PMC
March 2019
4 Reads

Photoaging and actinic keratosis in Danish outdoor and indoor workers.

Photodermatol Photoimmunol Photomed 2019 Jan 28. Epub 2019 Jan 28.

The Department of Dermatology, Zealand University Hospital Roskilde, Roskilde, Denmark.

Background: The risk of photoaging and actinic keratosis caused by work related solar ultraviolet radiation exposure has not previously been investigated in Nordic countries. The objectives of this study were to describe the occurrence of photoaging, actinic keratosis, and keratinocyte cancer in a population of Danish outdoor and indoor workers, and investigate the association between these clinical findings and semi-objective measures of work related solar ultraviolet radiation exposure in the same population.

Methods: A clinical cross-sectional study of the occurrence of facial wrinkles, actinic keratosis, keratinocyte cancer, and melanocytic nevi in a population of Danish outdoor and indoor workers and associations with semi-objective measures of work related solar ultraviolet radiation exposure based on a combination of dosimetry and self-report. Read More

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http://dx.doi.org/10.1111/phpp.12451DOI Listing
January 2019
2 Reads

Pluripotency markers are differentially induced by IGF1 and bFGF in cells from patients' lesions of large/giant congenital melanocytic nevi.

Biomark Res 2019 14;7. Epub 2019 Jan 14.

Department of Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA.

Factors regulating transcription of pluripotency genes in congenital nevo-melanocytes are not known. Nevo-melanocytes belong somewhere in-between the ends of a spectrum where the normal epidermal melanocyte represents one end and a melanoma cell with multiple genetic abnormalities represents the other. Cells from large/giant congenital nevi (L/GCMN), unlike normal melanocytes, grow colonies on soft agar and express pluripotency markers, similar to melanoma cells. Read More

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http://dx.doi.org/10.1186/s40364-018-0152-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332894PMC
January 2019
9 Reads

Congenital nevi with hypomelanosis and fine scales.

Eur J Dermatol 2019 Feb;29(1):45-48

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo.

Background: Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed.

Objectives: To present two cases of congenital nevi with hypomelanosis and superficial fine scales. Read More

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http://dx.doi.org/10.1684/ejd.2018.3496DOI Listing
February 2019
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Expression of p15 in a spectrum of spitzoid melanocytic neoplasms.

J Cutan Pathol 2019 Jan 21. Epub 2019 Jan 21.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Accurate classification of spitzoid melanocytic lesions is difficult due to overlapping clinical and histopathologic features between Spitz nevi, atypical Spitz tumors (ASTs), and spitzoid melanomas. Expression of p16 (CDKN2A) has been used as a marker of spitzoid lesions. However, its expression may be variable. Read More

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http://doi.wiley.com/10.1111/cup.13424
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http://dx.doi.org/10.1111/cup.13424DOI Listing
January 2019
10 Reads

Effect of Size and Location of Nevi on Postoperative Pain and Emergence Agitation in Children Undergoing Nevi Excision.

J Clin Med 2019 Jan 17;8(1). Epub 2019 Jan 17.

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon 164, Korea.

Congenital melanocytic nevi need surgical excisions. However, the effect of the size and location of the nevi on pain and emergence agitation have yet to be studied. The objective of this study was to evaluate (1) the ideal parameter of the nevus size and (2) the effects of the size and location of the nevus on pain and emergence agitation. Read More

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http://www.mdpi.com/2077-0383/8/1/106
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http://dx.doi.org/10.3390/jcm8010106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352197PMC
January 2019
6 Reads

Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression.

Pediatr Dermatol 2019 Mar 18;36(2):232-235. Epub 2019 Jan 18.

Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

We described the development of multiple melanocytic nevi within long-standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory-like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. Read More

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http://dx.doi.org/10.1111/pde.13738DOI Listing
March 2019
4 Reads

Clinicopathologic, misdiagnosis, and survival differences between clinically amelanotic melanomas and pigmented melanomas.

J Am Acad Dermatol 2019 May 14;80(5):1292-1298. Epub 2019 Jan 14.

Pigmented Lesion Clinic and Cutaneous Oncology Program, Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Amelanotic malignant melanoma (AMM) is challenging to diagnose. Clinical risk factors for AMM are not well defined.

Objective: To investigate clinicopathologic, misdiagnosis, and survival differences between patients with AMM and those with pigmented malignant melanoma (PMM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193008
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http://dx.doi.org/10.1016/j.jaad.2019.01.012DOI Listing
May 2019
17 Reads
4.449 Impact Factor

Hyperspectral imaging in automated digital dermoscopy screening for melanoma.

Lasers Surg Med 2019 Mar 17;51(3):214-222. Epub 2019 Jan 17.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York.

Objectives: Early melanoma detection decreases morbidity and mortality. Early detection classically involves dermoscopy to identify suspicious lesions for which biopsy is indicated. Biopsy and histological examination then diagnose benign nevi, atypical nevi, or cancerous growths. Read More

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http://doi.wiley.com/10.1002/lsm.23055
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http://dx.doi.org/10.1002/lsm.23055DOI Listing
March 2019
42 Reads

Common Neonatal Skin Lesions: Melanocytic Nevi, Pigment Alterations, and Nonmelanocytic Nevi.

Pediatr Ann 2019 Jan;48(1):e23-e29

Birthmarks are common in the healthy population and are generally harmless. Certain presentations, however, raise concern for associated syndromes or potential complications. It is important for pediatricians to be familiar with both harmless and potentially concerning birthmarks. Read More

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http://dx.doi.org/10.3928/19382359-20181207-01DOI Listing
January 2019

[Repair of skin and soft tissue defects of auricle and donor site with relay flap].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 01;33(1):66-69

Department of Burn Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563003, P.R.China.

Objective: To investigate the effectiveness of relay flap on repairing skin and soft tissue defect of auricle and donor site.

Methods: Between May 2014 and January 2016, 10 patients with auricular tumor were repaired by relay flap. There were 4 males and 6 females with an average age of 35 years (range, 21-69 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201807141
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http://dx.doi.org/10.7507/1002-1892.201807141DOI Listing
January 2019
19 Reads

Diagnostic utility of dual 5-hydroxymethylcytosine/Melan-A immunohistochemistry in differentiating nodal nevus from metastatic melanoma: An effective first-line test for the workup of sentinel lymph node specimen.

J Cutan Pathol 2019 Apr 31;46(4):261-266. Epub 2019 Jan 31.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

Background: Distinguishing benign nodal nevus from metastatic melanoma can be diagnostically challenging, with important clinical consequences. Recently, the loss of epigenetic marker, 5-hydroxymethylcytosine (5-hmC) expression by immunohistochemistry has been found in melanomas and atypical melanocytic neoplasms.

Methods: About 41 metastatic melanomas and 20 nodal nevi were retrieved. Read More

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http://dx.doi.org/10.1111/cup.13412DOI Listing
April 2019
8 Reads

Genomic Landscape of Spitzoid Neoplasms Impacting Patient Management.

Front Med (Lausanne) 2018 13;5:344. Epub 2018 Dec 13.

Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands.

Spitzoid neoplasms are a distinct group of melanocytic proliferations characterized by epithelioid and/ or spindle shaped melanocytes. Intermediate forms that share features of both benign Spitz nevi (SN) and Spitz melanoma, i.e. Read More

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http://dx.doi.org/10.3389/fmed.2018.00344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300473PMC
December 2018

Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma.

Am J Dermatopathol 2018 Dec 19. Epub 2018 Dec 19.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.

Background: Tumoral melanosis (TM) is a histologic diagnosis characterized by abundant pigment-laden macrophages in the dermis. It is generally thought to represent a regressed melanoma, although it has also been reported after benign pigmented lesions as well. Determining the antecedent lesion in cases of TM is of clinical importance to accurately guide therapy and prognostication. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001346DOI Listing
December 2018
5 Reads