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    The diagnostic value and histologic correlate of distinct patterns of shiny white streaks for the diagnosis of melanoma: a retrospective, case-control study.
    J Am Acad Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
    Background: Shiny white streaks (SWS) are best visualized with polarized dermoscopy, and correlate with dermal fibroplasia histopathologically. SWS have been described at higher frequencies in melanomas than benign nevi.

    Objective: We assessed the diagnostic value of different patterns of SWS and their histologic correlate in melanocytic lesions. Read More

    Keratinocyte Sonic Hedgehog Up-regulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion.
    J Invest Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Electronic address:
    Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Read More

    Pigmented Spindle Cell Nevus of Reed of the Eyelid.
    Ocul Oncol Pathol 2017 Sep 27;3(3):176-180. Epub 2017 Jan 27.
    Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.
    Purpose: To report the clinical, pathological, and immunohistochemical features of the first pigmented spindle cell nevus (PSCN) of Reed documented to have appeared in the eyelid.

    Methods: The findings of clinical and histopathological examination are presented, along with differential diagnoses and a review of the pertinent literature.

    Case: A 3-year-old boy presented with a rapidly growing, heavily pigmented left lower lid papule raising the concern of malignancy, warranting excisional biopsy. Read More

    Role of amniotic membrane and full-thickness skin graft in reconstruction of kissing nevus of eyelids.
    Indian J Ophthalmol 2017 Nov;65(11):1219-1221
    Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 20-year-old girl presented with a large pigmented lesion over the temporal aspect of left lateral canthus involving the lateral one-third of both eyelids, since birth. A slow increase in its size had been noticed for the past 2 years. On examination, a hairy nevus measuring 34 mm × 22 mm was noticed involving left eyelid skin, the mucocutaneous junction (MCJ), palpebral conjunctiva, and lateral canthus. Read More

    Resection of melanocytic nevi as a potential treatment of anti-NMDAR encephalitis patients without tumor: report of three cases.
    Neurol Sci 2017 Nov 11. Epub 2017 Nov 11.
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    The most common underlying tumor associated with anti-N-methyl D-aspartate-receptor (NMDAR) encephalitis is ovarian teratoma. Resection of the underlying tumor may decrease exposure of autoantigen and make for faster response of immunotherapy and less relapse frequency. Similar to teratoma, expression of NMDAR in human epidermal melanocytes was suspected recently. Read More

    Expression of Glut-1 in Malignant Melanoma and Melanocytic Nevi: an Immunohistochemical Study of 400 Cases.
    Pathol Oncol Res 2017 Nov 11. Epub 2017 Nov 11.
    Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studnickova 2, 12800, Prague 2, Czech Republic.
    The glucose transporter-1 (Glut-1) is a cell membrane glycoprotein involved in glucose uptake. An increased expression of Glut-1 is an important cell adaptation mechanism against hypoxia. An upregulation of Glut-1 can be found in several types of malignant tumors, which are able to reprogram their metabolism from oxidative phosphorylation to aerobic glycolysis (Warburg effect). Read More

    Integration of dermoscopy and reflectance confocal microscopy for distinguishing melanomas from nevi of the breast area.
    J Eur Acad Dermatol Venereol 2017 Nov 10. Epub 2017 Nov 10.
    Dermatology Unit, University of Modena and Reggio Emilia, Italy.
    Background: Nevi of special sites encompass a class of benign lesions characterized by the presence of atypical clinical and histopathologic features that can be difficult to distinguish from melanoma. Dermoscopy and reflectance confocal microscopy may improve the clinical assessment of melanocytic lesions in order to avoid unnecessary excisions.

    Objectives: The aim of this study was to assess the value of specific dermoscopic and confocal criteria in distinguishing melanomas from nevi of the breast area. Read More

    Collision Tumor between Trichofolliculoma and Melanocytic Nevus.
    Int J Trichology 2017 Oct-Dec;9(4):181-183
    Department of Pathology, Clínica Las Condes, Santiago, Chile.
    Trichofolliculoma (TF) is a hamartomatous hair follicle-related tumor, clinically described as a dome-shaped papule with a central pore crossed by one or more silky white hairs. Histologically, it described as a cystic cavity containing keratinous debris, hair shaft fragments, and numerous hair follicles arising from its linings. Collision or compound tumors are a coexistence of two or more identifiable tumors in the same lesion. Read More

    Reinterpreting dermoscopic pigment network with Reflectance Confocal Microscopy for identification of Melanoma specific features.
    J Eur Acad Dermatol Venereol 2017 Nov 8. Epub 2017 Nov 8.
    Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
    Background: Pigment network is an important dermoscopic features for melanocytic lesions but alterations in grid line thickness are also observed in melanomas.

    Objective: To investigate features of thick, thin and mixed pigment networks at dermoscopy and their respective features at Reflectance Confocal Microscopy (RCM) for differential diagnosis, correlated with histology METHODS: All melanocytic lesions with histological diagnosis, evaluated between January 2010 - May 2014, were enrolled and classified according to dermoscopy evaluation of the pigment network; thin, thick and mixed.

    Results: Thin network in melanoma was characterized by a honeycombed pattern (p<0. Read More

    Immunohistochemical expression of vitamin D receptor in melanocytic nevi and cutaneous melanoma. A case-control study.
    Br J Dermatol 2017 Nov 6. Epub 2017 Nov 6.
    Melanoma and Skin Cancer Unit, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Background: Vitamin D (VD) deficiency is associated with higher risk of cancer, possibly due to anti-proliferative, anti-angiogenic, pro-apoptotic, cell-differentiating and anti-invasive effects. The anti-carcinogenic role of VD in melanoma is still a matter of debate. Loss of nuclear and cytoplasmic vitamin D Receptor (VDR) expression in melanoma cells has been reported. Read More

    Eccrine-Centric Melanocytic Nevus.
    Am J Dermatopathol 2017 Oct 27. Epub 2017 Oct 27.
    *Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL; †Metropolitan Dermatologic Surgery, Atlanta, GA; ‡Pathology and Laboratory Medicine Service, James A. Haley VA Hospital, Tampa, FL; §Georgia Dermatopathology, Savannah, GA; and ¶Department of Dermatology, University of Florida, Gainesville, FL.
    Benign melanocytic neoplasms present with a diverse array of well-known histopathologic patterns. It is imperative to recognize the benign patterns to render accurate diagnoses. We describe here an interesting and hitherto not described low-power architectural pattern of a benign melanocytic lesion: eccrine-centric melanocytic nevus. Read More

    Population-Based Analysis of Histologically Confirmed Melanocytic Proliferations Using Natural Language Processing.
    JAMA Dermatol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Medicine, University of Washington School of Medicine, Seattle.
    Importance: Population-based information on the distribution of histologic diagnoses associated with skin biopsies is unknown. Electronic medical records (EMRs) enable automated extraction of pathology report data to improve our epidemiologic understanding of skin biopsy outcomes, specifically those of melanocytic origin.

    Objective: To determine population-based frequencies and distribution of histologically confirmed melanocytic lesions. Read More

    Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure.
    PLoS One 2017 1;12(11):e0186958. Epub 2017 Nov 1.
    Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
    We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later. Read More

    Dermoscopy of congenital melanocytic nevi: a ten-year follow-up study and comparative analysis with acquired melanocytic nevi arising in prepubertal age.
    Eur J Dermatol 2017 Oct;27(5):505-510
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Italy.
    Dermoscopic characteristics of congenital melanocytic nevi (CMN) have been reported, however, dermoscopic variation during long-term follow-up and direct comparative analyses with acquired melanocytic nevi (AMN) are poorly documented. To assess dermoscopic changes of CMN (including lesions present at birth or appearing within the first two years of age) after a long-term period and evaluate possible dermoscopic differences with AMN arising during prepubertal age. We re-analysed clinical and dermoscopic features of CMN, investigated ten years earlier. Read More

    Gene Expression Signature as an Ancillary Method in the Diagnosis of Desmoplastic Melanoma.
    Hum Pathol 2017 Oct 24. Epub 2017 Oct 24.
    Memorial Sloan Kettering Cancer Center, New York, NY, 10065. Electronic address:
    Desmoplastic melanoma (DM) is a rare fibrosing variant of melanoma that can be difficult to diagnose. One of the diagnostic challenges is its distinction from a melanocytic nevus with desmoplasia. Here we investigate the use of a 23-gene signature, which has previously been shown to distinguish benign from malignant melanocytic neoplasms. Read More

    Laser treatment of congenital melanocytic nevi: a systematic review.
    Br J Dermatol 2017 Oct 27. Epub 2017 Oct 27.
    Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Centre, University of Amsterdam, The Netherlands.
    Recent studies on congenital melanocytic nevi (CMN) indicate a lower risk for melanoma than assumed for many years. As a result, the treatment paradigm in CMN shifted from complete removal to cosmetically acceptable, less invasive treatment options such as laser treatment. Our objective was to systematically review the efficacy and safety of laser therapy for CMN. Read More

    Acquisition of Somatic NRAS Mutations in Central Nervous System Melanocytes: A Predisposing Risk Factor to Primary Melanoma of the Central Nervous System, a Frequently Forgotten Pitfall in Congenital Nevi.
    Am J Dermatopathol 2017 Oct 17. Epub 2017 Oct 17.
    Departments of *Pathology, and †Dermatology, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain.
    Congenital melanocytic nevi (CMN) are benign melanocytic proliferations that are usually present at birth. A somatic mosaicism for an NRAS point mutation is responsible for the several phenotypic abnormalities that may be associated with congenital nevi. We report the case of a 7-year-old boy with a proliferative nodule (PN) arising in a Giant CMN completely excised and with several visceral and intraspinal melanoma metastases with no evidence of primary cutaneous melanoma. Read More

    Serial Tissue Expansion at the Same Site in Pediatric Patients: Is the Subsequent Expansion Faster?
    Arch Plast Surg 2017 Oct 26. Epub 2017 Oct 26.
    Department of Plastic and Reconstructive Surgery, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, Seoul, Korea.
    Background: Serial tissue expansion is performed to remove giant congenital melanocytic nevi. However, there have been no studies comparing the expansion rate between the subsequent and preceding expansions. In this study, we analyzed the rate of expansion in accordance with the number of surgeries, expander location, expander size, and sex. Read More

    Classifying dermoscopic patterns of naevi in a case-control study of melanoma.
    PLoS One 2017 17;12(10):e0186647. Epub 2017 Oct 17.
    Dermatology Research Centre, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.
    Changes in dermoscopic patterns of naevi may be associated with melanoma; however, there is no consensus on which dermoscopic classification system is optimal. To determine whether different classification systems give comparable results and can be combined for analysis, we applied two systems to a case-control study of melanoma with 1037 participants: 573 classified using a "1/3 major feature" system, 464 classified based on rules of appearance, and 263 classified with both criteria. There was strong correlation for non-specific (Spearman R = 0. Read More

    Clinical and dermoscopic characterization of pediatric and childhood melanomas. Multicenter study of 52 cases.
    J Am Acad Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:
    Background: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse and this may in part contribute to delay in detection and thicker tumors.

    Objective: to analyze the clinical-dermoscopic characteristics of PM.

    Methods: retrospective study of 52 melanomas diagnosed before age of 20. Read More

    Agminated segmental plaque-type blue nevus associated with hypertrichosis and soft tissue hypertrophy: Report of a case and review of the literature.
    Pediatr Dermatol 2017 Oct 11. Epub 2017 Oct 11.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Blue nevi are common skin neoplasms that typically present as asymptomatic solitary papules, although they may rarely occur in an agminated configuration. We describe a case of agminated blue nevus in a segmental facial distribution associated with soft tissue hypertrophy and hypertrichosis in a 16-year-old boy and present a review of the literature. Although they are generally considered to be benign, concurrent soft tissue changes occurring within an agminated blue nevus should be investigated thoroughly to exclude alternate diagnoses. Read More

    Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus.
    Med J Aust 2017 Oct;207(8):333-338
    Victorian Melanoma Service, Alfred Hospital, Melbourne, VIC.
    Objectives: To determine the frequency of naevus-associated melanoma among superficial spreading and nodular subtypes; and to investigate associations between naevus-associated melanoma and other clinico-pathological characteristics.

    Design, Setting And Participants: Cross-sectional study of all patients with nodular and superficial spreading melanomas diagnosed between 1994 and 2015 at the Victorian Melanoma Service, Melbourne.

    Methods And Main Outcome Measures: Clinical and pathological characteristics of naevus-associated and de novo melanomas were assessed in univariable and multivariable logistic regression analyses. Read More

    A prospective study evaluating the utility of a 2-mm biopsy margin for complete removal of histologically atypical (dysplastic) nevi.
    J Am Acad Dermatol 2017 Dec 2;77(6):1096-1099. Epub 2017 Oct 2.
    Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:
    Background: Complete removal of individual dysplastic nevi (DN) is often accomplished by a second surgical procedure after the initial biopsy. The choice to perform the second procedure is strongly influenced by histopathologic margin status of the initial biopsy specimen.

    Objective: To evaluate the clinical and histopathologic outcomes of in toto biopsy of DN using a predetermined margin of normal skin. Read More

    Noninvasive diagnosis in dermatology.
    J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016
    Department of Dermatology and Allergology, Augsburg Medical Center, Augsburg, Germany.
    In addition to dermoscopy, there are other imaging and biophysical methods for the noninvasive diagnosis of skin lesions. Confocal laser microscopy allows for high-resolution imaging of the epidermis and upper dermis. It is particularly suitable in the differential diagnosis of melanocytic lesions. Read More

    The recurrent nevus phenomenon.
    An Bras Dermatol 2017 Jul-Aug;92(4):531-533
    Department of Clinical Medicine, Universidade Federal de Santa Maria (UFSM) - Santa Maria (RS), Brazil.
    Recurrent melanocytic nevus is a proliferation of melanocytes arising from a melanocytic nevus removed partially. Asymmetry and irregular pigmentation may lead to misdiagnosis of melanoma. We report a patient presented with a lesion on the lower abdomen, which was removed by shave excision. Read More

    Congenital melanocytic nevus mimicking a turban tumour in an 18-year-old Filipino male.
    BMJ Case Rep 2017 Sep 23;2017. Epub 2017 Sep 23.
    Department of Surgery, Division of Plastic Surgery, University of the Philippines Manila, Philippine General Hospital, Manila, Philippines.
    Congenital melanocytic nevi (CMN) are nevi that are present at birth or arise within the first few weeks of life. They are often found on the trunk, head and neck and extremities. We report herein an unusual presentation of a CMN as a cerebriform tumour presenting as secondary cutis verticis gyrata on the scalp of an 18-year-old Filipino male. Read More

    Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi.
    Nat Commun 2017 Sep 21;8(1):644. Epub 2017 Sep 21.
    Department of Biopathology, Centre Léon Bérard, Lyon, 69008, France.
    Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathways as characteristic of DPN. Read More

    Pigmented Trichoblastoma of Nose: An Unusual Occurrence.
    J Clin Diagn Res 2017 Jul 1;11(7):MD09-MD10. Epub 2017 Jul 1.
    Junior Resident, Department of Ear, Nose and Throat, Sri Siddhartha Medical College, Agalakote, Karnataka, India.
    Nevus sebaceus of Jadassohn is a congenital tumour affecting the scalp and face. It is usually presented as a pigmented patch or plaque. It is a complex cutaneous hamartoma which involves pilosebaceous follicle, epidermis and adnexal structures. Read More

    Proteomic Mass Spectrometry Imaging for Skin Cancer Diagnosis.
    Dermatol Clin 2017 Oct 11;35(4):513-519. Epub 2017 Jul 11.
    Protea Biosciences, Inc, 1311 Pineview Drive, Suite 501, Morgantown, WV 26505, USA.
    Mass spectrometry imaging can be successfully used for skin cancer diagnosis, particularly for the diagnosis of challenging melanocytic lesions. This method analyzes proteins within benign and malignant melanocytic tumor cells and, based on their differences, which constitute a unique molecular signature of 5 to 20 proteins, can render a diagnosis of benign nevus versus malignant melanoma. Mass spectrometry imaging may assist in the differentiation between metastases and nevi as well as between proliferative nodules in nevi and melanoma arising in a nevus. Read More

    Mole Mapping for Management of Pigmented Skin Lesions.
    Dermatol Clin 2017 Oct 7;35(4):439-445. Epub 2017 Aug 7.
    The Ronald O. Perelman Department of Dermatology, NYU School of Medicine, 240 East 38th Street, 11th Floor, New York, NY 10016, USA.
    Identifying new or changing melanocytic lesions, particularly in patients with numerous or atypical nevi, can be challenging. Total-body photography and sequential digital dermoscopy imaging, together known as digital follow-up, are 2 prominent forms of noninvasive imaging technology used in mole mapping that have been found to improve diagnostic accuracy, detect earlier-stage melanomas, and reduce costs. Digital follow-up, in combination with direct-to-consumer applications and teledermatology, is already revolutionizing the ways in which physicians and patients participate in melanoma surveillance and will likely continue to enhance early detection efforts. Read More

    Clinical and Spectral-Domain Optical Coherence Tomography Appearance of Optic Disc Melanocytoma: A New Classification and Differentiation from Pigmented Choroidal Lesions.
    Ocul Oncol Pathol 2017 Jul 14;3(2):142-148. Epub 2016 Dec 14.
    UCLA Stein Eye Institute, Los Angeles, CA, USA.
    Aims: The aim of this paper was to compare the features of both the classic, darkly pigmented and the atypical, more lightly pigmented optic disc melanocytoma with those of pigmented choroidal lesions.

    Methods: We analyzed the spectral-domain optical coherence tomography (SD-OCT) features of 9 eyes with optic disc melanocytoma and compared them with those of choroidal melanoma and nevus.

    Results And Conclusion: We identified 2 categories of SD-OCT findings in optic disc melanocytoma: (a) type 1, the typical, prominent, hyperpigmented lesion with SD-OCT findings of a hyperreflective, disorganized overlying retina and a posterior hyporeflective shadow, and (b) the less common, atypical, minimally pigmented type 2 lesion overlaid by a relatively well-organized retina that lacks a posterior hyporeflective shadow. Read More

    Oral melanoma and other pigmentations: when to biopsy?
    J Eur Acad Dermatol Venereol 2017 Sep 1. Epub 2017 Sep 1.
    Dermatology, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Oral pigmentations (OPs) are often neglected, although a meticulous examination of the oral cavity is important not only in the diagnosis of oral melanoma, but also for the detection of important clinical findings that may indicate the presence of a systemic disease. OPs may be classified into two major groups on the basis of their clinical appearance: focal and diffuse pigmentations, even though this distinction may not appear so limpid in some cases. The former include amalgam tattoo, melanocytic nevi, melanoacanthoma and melanosis, while the latter include physiological/racial pigmentations, smoker's melanosis, drug-induced hyperpigmentations, postinflammatory hyperpigmentations and OPs associated with systemic diseases. Read More

    Pediatric conjunctival melanoma arising from a compound nevus.
    J AAPOS 2017 Oct 30;21(5):416-418. Epub 2017 Aug 30.
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina. Electronic address:
    We present a rare case of conjunctival melanoma in a 9-year-old girl who presented with a conjunctival lesion of the left eye, growth of which was documented by patient photographs. Examination showed a raised pigmented lesion at the temporal limbus, with fine surrounding vessels. Enhanced depth imaging-optical coherence tomography showed no invasion into the sclera. Read More

    [Analysis of clinicopathologic characteristics of 422 conjunctival melanocytic nevi specimens].
    Zhonghua Yan Ke Za Zhi 2017 Aug;53(8):583-587
    Beijing Institute of Ophthalmology, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology&visual sciences key lab., Beijing 100005, China.
    Objective: To describe the clinicopathologic characteristics of 422 conjunctival melanocytic nevi and detect the incidence of malignancy in those patients. Methods: Retrospective case series study. A retrospective study was conducted by reviewing 422 conjunctival melanocytic nevi specimens obtained at Beijing Tongren Eye Center from June, 2004 to May, 2016. Read More

    Evaluation of expression of genes CADM1, TWIST1 and CDH1 by immunohistochemestry in melanocytic lesions.
    Pathol Res Pract 2017 Sep 1;213(9):1067-1071. Epub 2017 Aug 1.
    Universidade da Região de Joinville - UNIVILLE, Paulo Malschitzki St, 10, 89219-710, Joinville, Santa Catarina, Brazil.
    Aim: Malignant melanoma is an aggressive disease and its incidence is increasing worldwide. Genetic predisposition and exposure to environmental factors, especially sunlight, are risk factors. Histopathologic distinction between nevi and melanomas can be difficult. Read More

    Blue rubber bleb nevus syndrome: our experience and new endoscopic management.
    Medicine (Baltimore) 2017 Aug;96(33):e7792
    aDepartment of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province bDepartment of Nephrology, Jilin City Central Hospital, Jilin, Jilin Province, China.
    The aim of our study is to enhance the awareness of blue rubber bleb nevus syndrome (BRBNS) through the patients in our hospital and introduced a new measure of endoscopic intervention.A retrospective review of 5 patients, who were diagnosed as BRBNS in our hospital from January 2013 to January 2017, was conducted. Data were collected with regard to demographics, clinical presentation, endoscopic and imaging findings, management, and follow-up data. Read More

    Alkaptonuria: A Case Report With Diagnostic Challenge.
    S D Med 2017 Aug;70(8):366-368
    Department of Dermatology, University of South Dakota Sanford School of Medicine.
    Alkaptonuria is a rare autosomal recessive metabolic disorder caused by deficiency of homogentisic acid (HGA) oxidase, the only enzyme capable of catabolizing HGA. Deficiency of this enzyme leads to excess HGA which deposits in the connective tissue. We present a case of a 64-year-old woman who was referred to the dermatology clinic for a full body mole check and skin cancer screening. Read More

    Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus.
    Int J Mol Sci 2017 Aug 15;18(8). Epub 2017 Aug 15.
    Departments of Dermatology and Pathology, University of Alabama at Birmingham, Birmingham, AL 35201, USA.
    Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. Read More

    Blue Nevi and Related Tumors.
    Clin Lab Med 2017 Sep 4;37(3):401-415. Epub 2017 Jul 4.
    Lahey Clinic, 41 Mall Road, Burlington, MA 018056, USA; www.DermatopathologyConsultations.com, C/O Harvard Vanguard Medical Associates Laboratories, 152 2nd Avenue, Needhan, MA 02494, USA. Electronic address:
    The major entities related to blue nevus are common blue nevus, cellular blue nevus, atypical blue nevus, and malignant blue nevus. These lesions share presence of dermal pigmented dendritic melanocytes derived from embryonal precursors to melanocytes, Schwann cells, and glial cells migrating to the skin from the ventral neural crest. Genetically, blue nevi harbor mutations in G-protein-coupled receptor subunits GNAQ and GNA11. Read More

    Cellular Blue Nevus of Perilimbal Conjunctiva: A Case Report and Review of Literature.
    Ann Clin Lab Sci 2017 Aug;47(4):477-480
    Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin China.
    Cellular blue nevus is an uncommon neoplasm in the conjunctiva. Here we present an unusual case of a cellular blue nevus that clinically resembled conjunctival melanoma. A 29-year-old Chinese male was found to have a giant pigmented lesion of the conjunctiva around the limbal area of right eye from birth. Read More

    Punch 'scoring': a technique that facilitates melanoma diagnosis of clinically suspicious pigmented lesions.
    Histopathology 2017 Aug 10. Epub 2017 Aug 10.
    Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
    Aims: Early recognition and accurate diagnosis underpins melanoma survival. Identifying early melanomas arising in association with pre-existing lesions is often challenging. Clinically suspicious foci, however small, must be identified and examined histologically. Read More

    Single-Stage Reconstruction of Eyebrow Defect Using a V-Y Advancement Pedicle Flap Based on the Orbicularis Oculi Muscle.
    J Craniofac Surg 2017 Sep;28(6):e521-e522
    Department of Plastic and Reconstructive Surgery, The First Bethune Hospital of Jilin University, Changchun, China.
    Eyebrows play an important role in face expression and facial mimics by virtue of muscle contraction. Defects or deformity of the eyebrows result in abnormal facial expressions, and may lead to aesthetic issues for patients. The objective of this study is to report the case of a patient, with a congenital skin pigmented nevus at the right side of the eyebrow treated with direct surgical resection and followed by immediate reconstruction of the eyebrow with a V-Y advancement pedicle flap based on the orbicularis oculi muscle. Read More

    Genomic Analysis of Pigmented Epithelioid Melanocytomas Reveals Recurrent Alterations in PRKAR1A, and PRKCA Genes.
    Am J Surg Pathol 2017 Oct;41(10):1333-1346
    Departments of *Pathology §Dermatopathology ∥Dermatology †Clinical Cancer Genomics Laboratory ‡Helen Diller Cancer Center, University of California, San Francisco, CA ¶Department of Pathology, Lahey Clinic, Burlington, MA.
    Pigmented epithelioid melanocytoma (PEM) is a rare cutaneous melanocytic tumor first described as epithelioid blue nevus in patients with the Carney Complex (CC). PEM was among the first established examples of an intermediate class of melanocytic tumors, including atypical Spitz tumors, with frequent metastasis to lymph nodes but only rare extranodal spread. Sporadic and CC-associated PEM are essentially histologically indistinguishable. Read More

    Giant Congenital Melanocytic Nevus (GCMN) - A New Hope for Targeted Therapy?
    Open Access Maced J Med Sci 2017 Jul 22;5(4):549-550. Epub 2017 Jul 22.
    Department of Dermatology and Venereology, Medical University of Plovdiv, 15A Vasil Aprilov blvd., 4002 Plovdiv, Bulgaria.
    We present a 6-month-old male patient, who was consulted with dermatologist by his parents, because of a pigmented lesion, present since birth, covering almost the all skin of the back and buttocks. A sharply bordered, unequally coloured congenital pigmented nevus, measuring approximately 21 cm in diameter was observed in the whole body skin examination. The lesion was affecting the lower 2/3 of the skin of the back and the top half of the gluteus area, extending to the lateral part of the tors, forward the abdomen and the upper lateral part of the hips, composed by multiple darker-pigmented nests and several lighter areas, with single depigmented zones, hairy surface, irregularly infiltrated on palpation. Read More

    Late Onset Achromatic Melanoma Arising in a Giant Congenital Melanocytic Nevus.
    Open Access Maced J Med Sci 2017 Jul 18;5(4):533-534. Epub 2017 Jul 18.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
    A 61-year-old woman, with a lifelong history of a giant congenital melanocytic nevus in the occipital region with secondary development of giant melanoma is presented. Surgical excision was performed, and the histopathological evaluation confirmed the diagnosis of Giant Malignant Melanoma (GMM) with a maximum tumour thickness of 16 mm. Nowadays, there is tremendous uncertainty regarding how giant congenital melanocytic nevi (GCMN) should be treated. Read More

    Vulvar Neoplasms, Benign and Malignant.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352
    Bethesda Dermpath Laboratory, 1730 Elton Road, Suite 11, Silver Spring, MD 20903, USA; Anne Arundel Dermatology, Towson, MD 21204, USA; Pathology, Johns Hopkins University, 4940 Bayview Medical Center, Eastern Avenue, Baltimore, MD 21224, USA. Electronic address:
    Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. Read More

    The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions.
    Per Med 2017 Mar 23;14(2):123-130. Epub 2017 Jan 23.
    Myriad Genetic Laboratories, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USA.
    Aim: The effect of a gene-expression-based test on treatment of melanocytic neoplasms by dermatologists was evaluated.

    Patients & Methods: Pathologists submitted diagnostically challenging melanocytic neoplasms to a clinical laboratory for testing accompanied by pretest surveys documenting the intended treatment recommendations. The actual treatment rendered by dermatologists was then documented after testing. Read More

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