Search Our Scientific Publications & Authors

J Am Acad Dermatol 2020 May 21. Epub 2020 May 21.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address:

Background: Atypical network encompasses several patterns. Few studies assess the sensitivity, specificity, and positive and negative predictive values of network subtypes.

Objective: We assessed the diagnostic value of atypical network subtypes and their histopathologic correlates in cutaneous melanocytic lesions. Read More

J Am Acad Dermatol 2020 May 19. Epub 2020 May 19.

The Kittner Skin Cancer Screening & Research Institute, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Melanoma in situ (MMIS) and dysplastic nevi with severe atypia (DNSA) present overlapping histopathological features. Reflectance Confocal Microscopy (RCM) findings can be integrated with the dermatopathology report to improve differentiation between melanoma and DNSA.

Objective: To compare prevalence of RCM findings between MMIS and DNSA METHODS: This retrospective observational study compared RCM findings in dermatopathologically-diagnosed DNSA and MMIS, collected between 2007-2017 at a private pigmented-lesion clinic. Read More

Plast Reconstr Surg Glob Open 2020 Apr 27;8(4):e2726. Epub 2020 Apr 27.

Department of Plastic Surgery, I.M. Sechenov First Moscow State Medical University Moscow, Russia.

Benign skin lesions of the face require appropriate surgical treatment. Giant pigmented skin lesions possess the high risk of malignancy which sometimes is not possible to diagnose preoperatively. Majority of the traditional techniques for lower lip and chin reconstruction were developed for the skin cancer resections and are extensively aggressive and disfiguring in case of benign lesions. Read More

FEBS Open Bio 2020 May 19. Epub 2020 May 19.

Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

Spitzoid neoplasms are a challenging group of cutaneous melanocytic proliferations. They are characterized by epithelioid and/ or spindle-shaped melanocytes and classified as benign Spitz nevi (SN), atypical Spitz tumors (AST) or malignant Spitz tumors (MST). The intermediate AST category represents a diagnostically challenging group since on purely histopathological grounds, their benign or malignant character remains unpredictable. Read More

Hereditas 2020 May 19;157(1):21. Epub 2020 May 19.

Department of Plastic and Reconstructive Surgery, Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Congenital melanocytic nevus (CMN) is a benign proliferative skin disease in the epidermis and dermis. Large to giant CMNs are estimated to be associated with an increased lifetime risk of malignancy. It is necessary to estimate and monitor the risk of malignant transformation for giant CMNs. Read More

J Eur Acad Dermatol Venereol 2020 May 13. Epub 2020 May 13.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: Melanocytic lesions with eccentric hyperpigmentation (EH), even though without other dermatoscopic features of melanoma, are often excised.

Objective: Aiming to understand if the EH in a pigmented lesion is an accurate criterion of malignancy, we evaluated the capability of two evaluators, with different expertise, to correctly diagnose a melanoma when analyzing a given lesion in toto versus a partial analysis, with only the EH or the non-hyperpigmented portion (non-EH) visible.

Methods: Dermatoscopic images of 240 lesions (107 melanomas and 133 nevi) typified by EH were selected. Read More

Zhonghua Bing Li Xue Za Zhi 2020 May;49(5):458-463

Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.

To study the genetic changes and biological potential of proliferative nodule in congenital melanocytic nevus. Whole-exome sequencing was carried out using the technique of next-generation sequencing (NGS) in order to detect the genomic alterations of two cases of proliferative nodules (PN) in congenital melanocytic nevi (CMN). Twelve cases of CMN and ten cases of malignant melanoma were used as benign and malignant controls, respectively. Read More

Cureus 2020 Apr 7;12(4):e7579. Epub 2020 Apr 7.

Dermatology, St. Joseph Dermatopathology, Houston, USA.

Tinea nigra is an uncommon superficial dermatomycosis precipitated by , a halophilic and halothermic yeast-like fungus capable of producing a melanin-like substance. This pathogen infiltrates the stratum corneum in the setting of microtrauma and produces an asymptomatic brown to black macule or patch that appears similarly to melanocytic nevi or melanoma. We present a case of a 52-year-old woman who presented to clinic several months after developing a painless, nonpruritic dark brown patch in her left foot inside the fourth toe web. Read More

Pigment Cell Melanoma Res 2020 May 9. Epub 2020 May 9.

Department of Biopathology, Center Léon Bérard, Lyon, France.

The genetic anomalies associated with the agminated variant of Spitz nevus have so far been limited to HRAS G13R mutations, especially when arising within a nevus spilus. A previous report exposed the case of a man with a giant pigmented macule involving his upper right limb and trunk. Since childhood, Spitz nevi have been periodically arising, within the pigmented area. Read More

J Dermatol 2020 May 4. Epub 2020 May 4.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.

Agminated nevus refers to a clustered group of melanocytic nevi confined to a localized area of the body. It rarely involves acral skin, but recognition of acquired agminated nevus (AAN) in the acral area is clinically important because it may mimic acral lentiginous melanoma (ALM). However, acral AAN has only been described in a few case reports and its clinical characteristics remain unclear. Read More

Dermatol Pract Concept 2020 3;10(2):e2020028. Epub 2020 Apr 3.

Dermatology Clinic, Hospital Maggiore, University of Trieste, Italy.

The association of melanoma with a preexisting nevus is still a debated subject. Histopathological data support an associated nevus in approximately 30% of all excised melanomas. The annual risk of an individual melanocytic nevus becoming malignant is extremely low and has been estimated to be approximately 0. Read More

J Am Acad Dermatol 2020 Apr 26. Epub 2020 Apr 26.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016. Electronic address:

Managing the balance between accurately identifying early-stage melanomas while avoiding biopsies of benign lesions (i.e. over-biopsy) is the major challenge of melanoma detection. Read More

Arch Dermatol Res 2020 Apr 27. Epub 2020 Apr 27.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Histopathologic assessment of melanocytic neoplasms is the current gold standard of diagnosis. However, there are well recognized limitations including inter-observer diagnostic discordance. This study aimed to determine if integrating dermoscopy with histopathology of melanocytic neoplasms impacts diagnosis and improves inter-observer agreement. Read More

J Cutan Pathol 2020 Apr 24. Epub 2020 Apr 24.

Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.

Background: Screening borderline Spitz tumors with p16 immunohistochemistry has known utility. The applicability to other melanocytic neoplasms is not well defined.

Methods: Cases (N = 104) of blue, cellular blue, epithelioid blue, congenital pattern, deep penetrating, desmoplastic, desmoplastic Spitz, acral, "epithelioid" nevi, nevoid melanoma, melanoma with a precursor nevus, and non-nevoid melanoma with Breslow thickness > 0. Read More

Pigment Cell Melanoma Res 2020 Apr 23. Epub 2020 Apr 23.

Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain.

Congenital melanocytic nevi (CMN) are cutaneous malformations whose prevalence is inversely correlated with projected adult size. CMN are caused by somatic mutations, but epidemiological studies suggest that germline genetic factors may influence CMN development. In CMN patients from the U. Read More

Orv Hetil 2020 04 1;161(15):563-574. Epub 2020 Apr 1.

Semmelweis Egyetem, Budapest, Mária u. 39., 1085.

Our purpose is to summarize the actual knowledge about melanocytic lesions of the ocular surface (conjunctival nevus, primary acquired melanosis and conjunctival melanoma),especially their clinical appearance, differential diagnosis and treatment. Conjunctival nevus is the most common benign, conjunctival melanocytic lesion. Primary acquired melanosis mainly presents in middle-aged or elderly individuals, characterized by proliferation of melanocytes of the conjunctival epithelial layer. Read More

Am J Surg Pathol 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, Memorial Sloan Kettering Cancer, New York, NY.

PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen. Although diffuse immunoreactivity for PRAME is found in most primary cutaneous melanomas, melanocytic nevi express PRAME usually only in a subpopulation of tumor cells or not at all. Hence, testing for PRAME expression has the potential to provide useful information for the assessment for diagnostically ambiguous melanocytic neoplasms. Read More

J Cosmet Dermatol 2020 Apr 21. Epub 2020 Apr 21.

Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: This study presents the results of complete excision of giant congenital melanocytic nevi (GCMN) on the auricle, forehead, or periorbital area combined with tissue expansion, and skin graft transplantation performed in two stages based on 10 years of experience.

Aims: To solve the giant congenital melanocytic nevi on the auricle, forehead, or periorbital area with two-stage operation.

Patients/methods: A total of 21 patients with GCMN were included in this study. Read More

Histopathology 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, First People's Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.

Aims: Longitudinal melanonychia in pediatric patients often represents a difficult diagnostic challenge and studies emphasizing on its clinical and histopathologic features are limited due to its low incidence in childhood.

Methods And Results: We retrospectively analyzed 35 pediatric cases identified by excision specimens on their clinicopathologic features, and performed fluorescence in situ hybridization test on available 13 cases. Fingernails (77. Read More

J Cutan Pathol 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, University of Pittsburgh School of Medicine, Division of Pediatric Pathology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.

In inflammatory dermatoses, dermal melanophages (MLP) are ascribed to "pigment incontinence", with melanin "dropping down" from the epidermis. Although this is analogous to the "dropping down" of melanocytic nevus cells (Abtropfung); MLP in ordinary nevi have not been systematically studied - so "pigment incontinence" may not apply to MLP in nevi. A total of 31 childhood nevi identified by pediatricians and family practitioners were evaluated for the distribution of MLP. Read More

Am J Dermatopathol 2020 Apr 17. Epub 2020 Apr 17.

Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA.

Cutaneous melanomas may demonstrate a variety of histopathological features and genetic abnormalities. Melanomas that arise in the setting of blue nevi, also known as "malignant blue nevus" or melanoma ex blue nevus (MBN), share a similar histopathological and mutational profile with uveal melanoma. Most uveal melanomas show characteristic GNA11 or GNAQ mutations; additional BAP1 mutation or loss is associated with the highest risk of metastasis and worst prognosis. Read More

Dermatol Ther 2020 Apr 14:e13407. Epub 2020 Apr 14.

Department of Dermatology, Şişli Etfal Training and Research Hospital, Health Sciences University, İstanbul, Turkey.

Eruptive melanocytic nevi (EMN) are rare multiple melanocytic lesions that rare and associated with dermatological and systemic diseases. Drug induced EMN is also reported with the use of biological or nonbiological chemotherapeutics, immunosuppressive agents, and melanocyte stimulators. In recent years, the increasing use of biological drugs resulted in an increased reports of EMN induced by these drugs. Read More

Pediatr Dermatol 2020 Apr 14. Epub 2020 Apr 14.

Department of Dermatology, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

Background/objective: There are limited data on the dermoscopic characteristics of acral nevi in the population under 18 years old. Our aim was to determine the frequency of acral volar nevi in children and adolescents, characterize their dermoscopic patterns, and identify relationships with age and location.

Methods: We prospectively examined the palms and soles of 1319 patients presenting to our outpatient clinic from July 2018 to April 2019. Read More

J Cutan Pathol 2020 Apr 15. Epub 2020 Apr 15.

Dermatopathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

This study piloted a pan-solid-tumor next generation sequence (NGS)-based laboratory developed test as a diagnostic aid in melanocytic tumors. 31 cases [4 "epithelioid" nevi, 5 blue nevi variants, 7 Spitz tumors (3 benign and 4 malignant) and 15 melanomas] were evaluated. All tumors [median diameter 7 mm (range 4-15 mm); median thickness 2. Read More

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Division of Clinical Dermatology and Cutaneous Science, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Early detection of melanoma is crucial to improving the detection of thin curable melanomas. Non-invasive, computer-assisted methods have been developed to use at the bedside to aid in diagnoses but have not been compared directly in a clinical setting.

Objective: We conducted a prospective diagnostic accuracy study comparing a dermatologist's clinical examination at the bedside, teledermatology, and non-invasive imaging techniques (FotoFinder®, Melafind®, Verisante Aura). Read More

Epilepsy Behav 2020 Jun 6;107:107061. Epub 2020 Apr 6.

Section of Pediatrics, Department of Medical Sciences, University of Ferrara, University Hospital Arcispedale Sant'Anna, Ferrara, Italy.

Purpose: Neurocutaneous melanosis (NCM) is a rare congenital syndrome characterized by giant melanocytic cutaneous nevi and melanosis within the central nervous system (CNS), often sparing leptomeninges and concentrated in the brain parenchyma. Epilepsy and neurodevelopmental abnormalities are the only complications reported in children with isolated parenchymal melanosis. A minority of patients experience drug-resistant epilepsy, and up to now, no predictors of epilepsy prognosis have been identified. Read More

Am J Dermatopathol 2020 Apr 7. Epub 2020 Apr 7.

Department of Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX.

The presence or absence of metastasis in sentinel lymph nodes often drives melanoma staging, prognosis, and treatment. However, distinguishing between metastatic melanoma cells and clusters of benign melanocytic nevus cells is not always straightforward. When morphologic hematoxylin and eosin interpretation alone is not sufficient, additional hematoxylin and eosin sections and immunohistochemical (IHC) studies may be beneficial. Read More

An Bras Dermatol 2020 Mar 19. Epub 2020 Mar 19.

Service of Dermatology Surgery, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Secondary osteoma cutis is a phenomenon that may occur in several conditions. When it occurs in a melanocytic nevus it is named osteonevus of Nanta, an event considered uncommon and characterized by the presence of bone formation adjacent or interposed with melanocytic cells. There are reports of its occurrence in various melanocytic lesions, being more frequently associated with intradermal nevus. Read More

Skin Res Technol 2020 Apr 6. Epub 2020 Apr 6.

Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, China.

Objective: To investigate the application and challenge of reflectance confocal microscopy (RCM) in the diagnosis of pigmented nevus.

Method: A total of 997 patients with clinical diagnosis of pigmented nevus were included in the study, and RCM imaging was performed on the lesion of each patient. A biopsy was performed in 78 of these patients for histological diagnosis. Read More

J Dermatol 2020 Apr 4. Epub 2020 Apr 4.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Neurofibromatosis type 1 (NF1) is a genodermatosis caused by heterozygous germ line variations in the NF1 gene. A second-hit NF1 aberration results in the formation of café-au-lait macules, cutaneous neurofibroma and plexiform neurofibroma (PNF). Mosaic NF1 (mNF1), caused by a postzygotic NF1 mutation, is characterized by localized or generalized NF1-related manifestations. Read More

Turk Pediatri Ars 2020 9;55(1):39-45. Epub 2020 Mar 9.

Department of Pediatric Hematology-Oncology, İstanbul University, Oncology Institute, İstanbul, Turkey.

Aim: Malignant melanoma is the most frequent skin cancer in children and adolescents. It comprises 1-3% of all malignancies. In this study, we aimed to evaluate the clinical aspects, histopathologic features, and treatment outcomes of our patients with malignant melanoma. Read More

Pathologe 2020 May;41(3):281-292

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

Malignant melanoma is an aggressive skin cancer that originates from cells of the melanocytic lineage and is associated with an invasive growth pattern and early spread. Besides endogenous risk factors such as fair skin type or genetic disposition for the formation of multiple nevi, exposure to ultraviolet light is the most important exogenous risk factor. Treatment of patients with primary tumors includes the complete excision of the primary lesion with appropriate safety margins and in patients with an increased risk of metastasis sentinel lymph node excision. Read More

J Cutan Pathol 2020 Mar 23. Epub 2020 Mar 23.

Laboratorio Recavarren Emanuel, Clínica Ricardo Palma, Lima, Peru.

Background And Objective: Located on chromosome locus 5p15.33, telomerase reverse transcriptase (TERT or hTERT) encodes the catalytic subunit of telomerase which permits lengthening and preservation of telomeres following mitosis. Mutations in TERT promoter (TERT-p) upregulate expression of TERT, allowing survival of malignant cells and tumor progression in wide variety of malignancies including melanoma. Read More

Diagn Cytopathol 2020 Jun 17;48(6):564-566. Epub 2020 Mar 17.

Department of Pathology, V.M.M.C and Safdarjung Hospital, New Delhi, India.

Malignant melanomas in the pediatric age are remarkably rare representing 0.9% of various pediatric malignancies. Congenital nevi occur in 1 in 100 newborns, whereas giant congenital melanocytic nevus (GCMN) measuring more than 20 cm is seen in 1 in 20 000 cases. Read More

Indian J Dermatol 2020 Mar-Apr;65(2):130-132

Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.

Becker's nevus, also known as pigmented hairy epidermal nevus, is characteristically described as a unilateral, hairy, light to dark brown macule with sharply outlined but irregular border. The etiopathogenesis of Becker's nevus is still not clearly understood. Perifollicular pigmentation has been described earlier by some authors. Read More

J Eur Acad Dermatol Venereol 2020 Mar 12. Epub 2020 Mar 12.

School of Medicine, Universidad Católica de Valencia San Vicente Mártir, València, Spain.

Background: Cutaneous melanoma patients have an increased risk of developing other neoplasms, especially cutaneous neoplasms and other melanomas. Identifying factors associated with an increased risk might be useful in the development of melanoma guidelines.

Objectives: To identify risk factors related to the development of a second primary melanoma in a series of patients diagnosed with sporadic melanoma and to establish the estimated incidence rate. Read More

Pediatr Dermatol 2020 Mar 10. Epub 2020 Mar 10.

Dermatology and Reference Center for Genodermatoses and Rare Skin Diseases (MAGEC), APHP, Institut Imagine, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France.

We report the case of a child who presented with a giant melanocytic nevus with numerous satellite nevi at birth and developed hypophosphatemic rickets due to excessive secretion of the FGF23 hormone. A NRAS c.182A>G (Q61R) mutation was identified in the lesional skin. Read More

J Invest Dermatol 2020 Mar 6. Epub 2020 Mar 6.

Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Am J Dermatopathol 2020 Mar 6. Epub 2020 Mar 6.

Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

ALK-fused spitzoid neoplasms represent a distinctive group of melanocytic lesions. To date, few studies addressed genetic and chromosomal alterations in these lesions beyond the ALK rearrangements. Our objective was to study genetic alterations, including ALK gene fusions, telomerase reverse transcriptase promoter (TERT-p) mutations, chromosomal copy number changes, and mutations in other genes. Read More

Pediatr Surg Int 2020 Apr 3;36(4):501-512. Epub 2020 Mar 3.

Department of Psychosomatics and Psychiatry, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.

Purpose: The role of surgery in the management of congenital melanocytic nevi (CMN) is controversial. Data on surgical outcomes and predictors of satisfaction remain scarce.

Methods: An online survey was employed following worldwide recruitment of youth aged 14-25 years (n = 44) and parents of children ≤ 18 years (n = 249) with CMN to query patterns of treatment and satisfaction with and opinions about the benefits of surgery. Read More

Am J Surg Pathol 2020 Jun;44(6):805-816

Departments of Pathology.

Melanocytic tumors with inactivation of protein kinase A regulatory subunit-α (PRKAR1A) have large oval nuclei and intense pigmentation. Historically, these tumors have been categorized under various names, including epithelioid blue nevus, pigmented epithelioid melanocytoma (PEM) and animal-type melanoma. Although a subset of PEM harbor BRAF activating mutations and biallelic inactivation of PRKAR1A, there are only a few reports of melanomas, or of tumors with genomic alterations beyond those of PEMs. Read More

Curr Health Sci J 2019 Oct-Dec;45(4):366-371. Epub 2019 Dec 30.

Department of Internal Medicine, Medical Center Dr. Ianosi, Craiova, Romania.

Early recognition of melanoma in situ (MIS) is an ongoing challenge in dermatology. It rarely arises 'de novo', most frequently resulting due to the transformation of an atypical nevus. The diagnostic criteria for MIS are diverse dermoscopy being the most used and it has a sensitivity of 83% and a specificity of 69% in detecting melanomas. Read More

G Ital Dermatol Venereol 2020 Feb;155(1):65-75

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy -

Nevus-associated melanoma (NAM) is defined on histopathological basis by the coexistence of melanoma and nevus components. Melanomas developing on pre-existing congenital or acquired nevi are usually of the superficial spreading subtype and harbor the BRAFV600E mutation. NAM accounts for almost one-third of melanoma cases As compared to de novo melanoma, NAM develops on younger patients, is more frequently located on the trunk, and is associated with a high nevus count, light eye color and history of frequent sunburns. Read More

Mod Pathol 2020 Feb 17. Epub 2020 Feb 17.

Departments of Pathology and Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Melanoma is the leading cause of death among cutaneous neoplasms. Best outcome relies on early detection and accurate pathologic diagnosis. For the great majority of melanocytic tumors, histopathologic examination can reliably distinguish nevi from melanomas. Read More

Mod Pathol 2020 Feb 17. Epub 2020 Feb 17.

Department of Pathology, Michigan Medicine, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USA.

Increasingly, molecular methods are being utilized in the workup of melanocytic neoplasms. To this end, we sought to correlate data from a single nucleotide polymorphism (SNP) array platform based on molecular inversion probes with clinical data. Copy number variation (CNV) data were obtained on 95 melanocytic tumors (6 ordinary nevi, 15 atypical nevi, 34 ambiguous neoplasms, and 40 melanomas) from 92 patients. Read More

Eur J Ophthalmol 2020 Feb 16:1120672120906999. Epub 2020 Feb 16.

Laboratorio di Genetica Medica, Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari Aldo Moro, Bari, Italy.

Purpose: We investigated the molecular causes of an unusual pigmented and ulcerated iris lesion detected in a patient diagnosed with neurofibromatosis type 1 (NF1).

Case Report: A 52-year-old man was referred to our clinic with a non-traumatic ulcer in his left eye. Hyphema reabsorption disclosed a pigmented iris mass, thus ultrasound biomicroscopy and anterior segment fluorescein angiography were performed to investigate for the presence of a malignant lesion. Read More

Arch Pathol Lab Med 2020 Apr 14;144(4):500-522. Epub 2020 Feb 14.

From the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia (Dr Elder); the Department of Dermatology, University of California San Francisco, San Francisco (Dr Bastian); International Agency for Research on Cancer, Lyon, France (Dr Cree); Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy (Dr Massi); and the Department of Pathology and Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia (Dr Scolyer).

Context.—: There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006.

Objective. Read More