11,746 results match your criteria Nevi Melanocytic


A Retrospective Cohort Study of the Diagnostic Value of Different Subtypes of Atypical Pigment Network on Dermoscopy.

J Am Acad Dermatol 2020 May 21. Epub 2020 May 21.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address:

Background: Atypical network encompasses several patterns. Few studies assess the sensitivity, specificity, and positive and negative predictive values of network subtypes.

Objective: We assessed the diagnostic value of atypical network subtypes and their histopathologic correlates in cutaneous melanocytic lesions. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.080DOI Listing

The role of reflectance confocal microscopy in differentiating melanoma in situ from dysplastic nevi with severe atypia: a cross-sectional study.

J Am Acad Dermatol 2020 May 19. Epub 2020 May 19.

The Kittner Skin Cancer Screening & Research Institute, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Melanoma in situ (MMIS) and dysplastic nevi with severe atypia (DNSA) present overlapping histopathological features. Reflectance Confocal Microscopy (RCM) findings can be integrated with the dermatopathology report to improve differentiation between melanoma and DNSA.

Objective: To compare prevalence of RCM findings between MMIS and DNSA METHODS: This retrospective observational study compared RCM findings in dermatopathologically-diagnosed DNSA and MMIS, collected between 2007-2017 at a private pigmented-lesion clinic. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.071DOI Listing

Achieving a Good Aesthetic Result in the Correction of Giant Nevus of the Labiomental Area.

Plast Reconstr Surg Glob Open 2020 Apr 27;8(4):e2726. Epub 2020 Apr 27.

Department of Plastic Surgery, I.M. Sechenov First Moscow State Medical University Moscow, Russia.

Benign skin lesions of the face require appropriate surgical treatment. Giant pigmented skin lesions possess the high risk of malignancy which sometimes is not possible to diagnose preoperatively. Majority of the traditional techniques for lower lip and chin reconstruction were developed for the skin cancer resections and are extensively aggressive and disfiguring in case of benign lesions. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209834PMC

A digital mRNA expression signature to classify challenging Spitzoid melanocytic neoplasms.

FEBS Open Bio 2020 May 19. Epub 2020 May 19.

Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

Spitzoid neoplasms are a challenging group of cutaneous melanocytic proliferations. They are characterized by epithelioid and/ or spindle-shaped melanocytes and classified as benign Spitz nevi (SN), atypical Spitz tumors (AST) or malignant Spitz tumors (MST). The intermediate AST category represents a diagnostically challenging group since on purely histopathological grounds, their benign or malignant character remains unpredictable. Read More

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http://dx.doi.org/10.1002/2211-5463.12897DOI Listing

Giant congenital melanocytic nevus of the scalp: from clinical-histological to molecular diagnosis.

Hereditas 2020 May 19;157(1):21. Epub 2020 May 19.

Department of Plastic and Reconstructive Surgery, Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Congenital melanocytic nevus (CMN) is a benign proliferative skin disease in the epidermis and dermis. Large to giant CMNs are estimated to be associated with an increased lifetime risk of malignancy. It is necessary to estimate and monitor the risk of malignant transformation for giant CMNs. Read More

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http://dx.doi.org/10.1186/s41065-020-00133-1DOI Listing

The presence of eccentric hyperpigmentation should raise the suspicion of melanoma.

J Eur Acad Dermatol Venereol 2020 May 13. Epub 2020 May 13.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: Melanocytic lesions with eccentric hyperpigmentation (EH), even though without other dermatoscopic features of melanoma, are often excised.

Objective: Aiming to understand if the EH in a pigmented lesion is an accurate criterion of malignancy, we evaluated the capability of two evaluators, with different expertise, to correctly diagnose a melanoma when analyzing a given lesion in toto versus a partial analysis, with only the EH or the non-hyperpigmented portion (non-EH) visible.

Methods: Dermatoscopic images of 240 lesions (107 melanomas and 133 nevi) typified by EH were selected. Read More

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http://dx.doi.org/10.1111/jdv.16604DOI Listing

[Genetic changes and biological potential of proliferative nodule in congenital pigmented nevus].

Zhonghua Bing Li Xue Za Zhi 2020 May;49(5):458-463

Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.

To study the genetic changes and biological potential of proliferative nodule in congenital melanocytic nevus. Whole-exome sequencing was carried out using the technique of next-generation sequencing (NGS) in order to detect the genomic alterations of two cases of proliferative nodules (PN) in congenital melanocytic nevi (CMN). Twelve cases of CMN and ten cases of malignant melanoma were used as benign and malignant controls, respectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190905-00485DOI Listing

Interdigital Tinea Nigra.

Cureus 2020 Apr 7;12(4):e7579. Epub 2020 Apr 7.

Dermatology, St. Joseph Dermatopathology, Houston, USA.

Tinea nigra is an uncommon superficial dermatomycosis precipitated by , a halophilic and halothermic yeast-like fungus capable of producing a melanin-like substance. This pathogen infiltrates the stratum corneum in the setting of microtrauma and produces an asymptomatic brown to black macule or patch that appears similarly to melanocytic nevi or melanoma. We present a case of a 52-year-old woman who presented to clinic several months after developing a painless, nonpruritic dark brown patch in her left foot inside the fourth toe web. Read More

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http://dx.doi.org/10.7759/cureus.7579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205379PMC

Novel three-way complex rearrangement of TRPM1-PUM1-LCK in a case of agminated Spitz nevi arising in a giant congenital hyperpigmented macule.

Pigment Cell Melanoma Res 2020 May 9. Epub 2020 May 9.

Department of Biopathology, Center Léon Bérard, Lyon, France.

The genetic anomalies associated with the agminated variant of Spitz nevus have so far been limited to HRAS G13R mutations, especially when arising within a nevus spilus. A previous report exposed the case of a man with a giant pigmented macule involving his upper right limb and trunk. Since childhood, Spitz nevi have been periodically arising, within the pigmented area. Read More

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http://dx.doi.org/10.1111/pcmr.12884DOI Listing

Acquired agminated melanocytic nevus in the acral area is a potential mimicker of acral lentiginous melanoma: A three-case series report and published work review.

J Dermatol 2020 May 4. Epub 2020 May 4.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.

Agminated nevus refers to a clustered group of melanocytic nevi confined to a localized area of the body. It rarely involves acral skin, but recognition of acquired agminated nevus (AAN) in the acral area is clinically important because it may mimic acral lentiginous melanoma (ALM). However, acral AAN has only been described in a few case reports and its clinical characteristics remain unclear. Read More

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http://dx.doi.org/10.1111/1346-8138.15353DOI Listing

Is There More Than One Road to Nevus-Associated Melanoma?

Dermatol Pract Concept 2020 3;10(2):e2020028. Epub 2020 Apr 3.

Dermatology Clinic, Hospital Maggiore, University of Trieste, Italy.

The association of melanoma with a preexisting nevus is still a debated subject. Histopathological data support an associated nevus in approximately 30% of all excised melanomas. The annual risk of an individual melanocytic nevus becoming malignant is extremely low and has been estimated to be approximately 0. Read More

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http://dx.doi.org/10.5826/dpc.1002a28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190536PMC

Technological advances for the detection of melanoma: Part I. Advances in diagnostic techniques.

J Am Acad Dermatol 2020 Apr 26. Epub 2020 Apr 26.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016. Electronic address:

Managing the balance between accurately identifying early-stage melanomas while avoiding biopsies of benign lesions (i.e. over-biopsy) is the major challenge of melanoma detection. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.03.121DOI Listing

Incorporation of dermoscopy improves inter-observer agreement among dermatopathologists in histologic assessment of melanocytic neoplasms.

Arch Dermatol Res 2020 Apr 27. Epub 2020 Apr 27.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Histopathologic assessment of melanocytic neoplasms is the current gold standard of diagnosis. However, there are well recognized limitations including inter-observer diagnostic discordance. This study aimed to determine if integrating dermoscopy with histopathology of melanocytic neoplasms impacts diagnosis and improves inter-observer agreement. Read More

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http://dx.doi.org/10.1007/s00403-020-02079-wDOI Listing
April 2020
2.270 Impact Factor

p16 Range of Expression in Dermal Predominant Benign Epithelioid and Spindled Nevi and Melanoma.

J Cutan Pathol 2020 Apr 24. Epub 2020 Apr 24.

Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.

Background: Screening borderline Spitz tumors with p16 immunohistochemistry has known utility. The applicability to other melanocytic neoplasms is not well defined.

Methods: Cases (N = 104) of blue, cellular blue, epithelioid blue, congenital pattern, deep penetrating, desmoplastic, desmoplastic Spitz, acral, "epithelioid" nevi, nevoid melanoma, melanoma with a precursor nevus, and non-nevoid melanoma with Breslow thickness > 0. Read More

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http://dx.doi.org/10.1111/cup.13721DOI Listing

Melanocortin-1 receptor (MC1R) genotypes do not correlate with size in two cohorts of medium-to-giant congenital melanocytic nevi.

Pigment Cell Melanoma Res 2020 Apr 23. Epub 2020 Apr 23.

Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain.

Congenital melanocytic nevi (CMN) are cutaneous malformations whose prevalence is inversely correlated with projected adult size. CMN are caused by somatic mutations, but epidemiological studies suggest that germline genetic factors may influence CMN development. In CMN patients from the U. Read More

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http://dx.doi.org/10.1111/pcmr.12883DOI Listing

Differential diagnosis and management of melanocytic lesions of the ocular surface

Orv Hetil 2020 04 1;161(15):563-574. Epub 2020 Apr 1.

Semmelweis Egyetem, Budapest, Mária u. 39., 1085.

Our purpose is to summarize the actual knowledge about melanocytic lesions of the ocular surface (conjunctival nevus, primary acquired melanosis and conjunctival melanoma),especially their clinical appearance, differential diagnosis and treatment. Conjunctival nevus is the most common benign, conjunctival melanocytic lesion. Primary acquired melanosis mainly presents in middle-aged or elderly individuals, characterized by proliferation of melanocytes of the conjunctival epithelial layer. Read More

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http://dx.doi.org/10.1556/650.2020.31699DOI Listing

Comparison of Immunohistochemistry for PRAME With Cytogenetic Test Results in the Evaluation of Challenging Melanocytic Tumors.

Am J Surg Pathol 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, Memorial Sloan Kettering Cancer, New York, NY.

PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen. Although diffuse immunoreactivity for PRAME is found in most primary cutaneous melanomas, melanocytic nevi express PRAME usually only in a subpopulation of tumor cells or not at all. Hence, testing for PRAME expression has the potential to provide useful information for the assessment for diagnostically ambiguous melanocytic neoplasms. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001492DOI Listing

Two-stage surgical treatment of giant congenital melanocytic nevus around the auricle.

J Cosmet Dermatol 2020 Apr 21. Epub 2020 Apr 21.

Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: This study presents the results of complete excision of giant congenital melanocytic nevi (GCMN) on the auricle, forehead, or periorbital area combined with tissue expansion, and skin graft transplantation performed in two stages based on 10 years of experience.

Aims: To solve the giant congenital melanocytic nevi on the auricle, forehead, or periorbital area with two-stage operation.

Patients/methods: A total of 21 patients with GCMN were included in this study. Read More

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http://dx.doi.org/10.1111/jocd.13416DOI Listing

Clinicopathologic diversity and outcome of longitudinal melanonychia in children and adolescents: Analysis of 35 cases identified by excision specimens.

Histopathology 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, First People's Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.

Aims: Longitudinal melanonychia in pediatric patients often represents a difficult diagnostic challenge and studies emphasizing on its clinical and histopathologic features are limited due to its low incidence in childhood.

Methods And Results: We retrospectively analyzed 35 pediatric cases identified by excision specimens on their clinicopathologic features, and performed fluorescence in situ hybridization test on available 13 cases. Fingernails (77. Read More

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http://dx.doi.org/10.1111/his.14121DOI Listing

A STUDY OF DERMAL MELANOPHAGES IN CHILDHOOD NEVI.

J Cutan Pathol 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, University of Pittsburgh School of Medicine, Division of Pediatric Pathology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.

In inflammatory dermatoses, dermal melanophages (MLP) are ascribed to "pigment incontinence", with melanin "dropping down" from the epidermis. Although this is analogous to the "dropping down" of melanocytic nevus cells (Abtropfung); MLP in ordinary nevi have not been systematically studied - so "pigment incontinence" may not apply to MLP in nevi. A total of 31 childhood nevi identified by pediatricians and family practitioners were evaluated for the distribution of MLP. Read More

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http://dx.doi.org/10.1111/cup.13718DOI Listing
April 2020
1.560 Impact Factor

Melanoma Ex Blue Nevus With GNA11 Mutation and BAP1 Loss: Case Report and Review of the Literature.

Am J Dermatopathol 2020 Apr 17. Epub 2020 Apr 17.

Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA.

Cutaneous melanomas may demonstrate a variety of histopathological features and genetic abnormalities. Melanomas that arise in the setting of blue nevi, also known as "malignant blue nevus" or melanoma ex blue nevus (MBN), share a similar histopathological and mutational profile with uveal melanoma. Most uveal melanomas show characteristic GNA11 or GNAQ mutations; additional BAP1 mutation or loss is associated with the highest risk of metastasis and worst prognosis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001652DOI Listing
April 2020
1.426 Impact Factor

Eruptive melanocytic nevi during etanercept treatment in an ankylosing spondylitis patient: Case report.

Dermatol Ther 2020 Apr 14:e13407. Epub 2020 Apr 14.

Department of Dermatology, Şişli Etfal Training and Research Hospital, Health Sciences University, İstanbul, Turkey.

Eruptive melanocytic nevi (EMN) are rare multiple melanocytic lesions that rare and associated with dermatological and systemic diseases. Drug induced EMN is also reported with the use of biological or nonbiological chemotherapeutics, immunosuppressive agents, and melanocyte stimulators. In recent years, the increasing use of biological drugs resulted in an increased reports of EMN induced by these drugs. Read More

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http://dx.doi.org/10.1111/dth.13407DOI Listing

Dermoscopic characteristics of acral melanocytic nevi in children and adolescents.

Pediatr Dermatol 2020 Apr 14. Epub 2020 Apr 14.

Department of Dermatology, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

Background/objective: There are limited data on the dermoscopic characteristics of acral nevi in the population under 18 years old. Our aim was to determine the frequency of acral volar nevi in children and adolescents, characterize their dermoscopic patterns, and identify relationships with age and location.

Methods: We prospectively examined the palms and soles of 1319 patients presenting to our outpatient clinic from July 2018 to April 2019. Read More

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http://dx.doi.org/10.1111/pde.14136DOI Listing

Targeted Next Generation Sequencing (NGS) to classify melanocytic neoplasms.

J Cutan Pathol 2020 Apr 15. Epub 2020 Apr 15.

Dermatopathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

This study piloted a pan-solid-tumor next generation sequence (NGS)-based laboratory developed test as a diagnostic aid in melanocytic tumors. 31 cases [4 "epithelioid" nevi, 5 blue nevi variants, 7 Spitz tumors (3 benign and 4 malignant) and 15 melanomas] were evaluated. All tumors [median diameter 7 mm (range 4-15 mm); median thickness 2. Read More

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http://dx.doi.org/10.1111/cup.13695DOI Listing

The Use of Non-Invasive Imaging Techniques in the Diagnosis of Melanoma: A Prospective Diagnostic Accuracy Study.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Division of Clinical Dermatology and Cutaneous Science, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Early detection of melanoma is crucial to improving the detection of thin curable melanomas. Non-invasive, computer-assisted methods have been developed to use at the bedside to aid in diagnoses but have not been compared directly in a clinical setting.

Objective: We conducted a prospective diagnostic accuracy study comparing a dermatologist's clinical examination at the bedside, teledermatology, and non-invasive imaging techniques (FotoFinder®, Melafind®, Verisante Aura). Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.019DOI Listing

Epilepsy in isolated parenchymal neurocutaneous melanosis: A systematic review.

Epilepsy Behav 2020 Jun 6;107:107061. Epub 2020 Apr 6.

Section of Pediatrics, Department of Medical Sciences, University of Ferrara, University Hospital Arcispedale Sant'Anna, Ferrara, Italy.

Purpose: Neurocutaneous melanosis (NCM) is a rare congenital syndrome characterized by giant melanocytic cutaneous nevi and melanosis within the central nervous system (CNS), often sparing leptomeninges and concentrated in the brain parenchyma. Epilepsy and neurodevelopmental abnormalities are the only complications reported in children with isolated parenchymal melanosis. A minority of patients experience drug-resistant epilepsy, and up to now, no predictors of epilepsy prognosis have been identified. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107061DOI Listing

Three Types of Nodal Melanocytic Nevi in Sentinel Lymph Nodes of Patients With Melanoma: Pitfalls, Immunohistochemistry, and a Review of the Literature.

Am J Dermatopathol 2020 Apr 7. Epub 2020 Apr 7.

Department of Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX.

The presence or absence of metastasis in sentinel lymph nodes often drives melanoma staging, prognosis, and treatment. However, distinguishing between metastatic melanoma cells and clusters of benign melanocytic nevus cells is not always straightforward. When morphologic hematoxylin and eosin interpretation alone is not sufficient, additional hematoxylin and eosin sections and immunohistochemical (IHC) studies may be beneficial. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001645DOI Listing

Osteonevus of Nanta: a case report in a combined melanocytic nevus.

An Bras Dermatol 2020 Mar 19. Epub 2020 Mar 19.

Service of Dermatology Surgery, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Secondary osteoma cutis is a phenomenon that may occur in several conditions. When it occurs in a melanocytic nevus it is named osteonevus of Nanta, an event considered uncommon and characterized by the presence of bone formation adjacent or interposed with melanocytic cells. There are reports of its occurrence in various melanocytic lesions, being more frequently associated with intradermal nevus. Read More

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http://dx.doi.org/10.1016/j.abd.2019.04.017DOI Listing

Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus.

Skin Res Technol 2020 Apr 6. Epub 2020 Apr 6.

Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, China.

Objective: To investigate the application and challenge of reflectance confocal microscopy (RCM) in the diagnosis of pigmented nevus.

Method: A total of 997 patients with clinical diagnosis of pigmented nevus were included in the study, and RCM imaging was performed on the lesion of each patient. A biopsy was performed in 78 of these patients for histological diagnosis. Read More

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http://dx.doi.org/10.1111/srt.12854DOI Listing

Genetic analyses of mosaic neurofibromatosis type 1 with giant café-au-lait macule, plexiform neurofibroma and multiple melanocytic nevi.

J Dermatol 2020 Apr 4. Epub 2020 Apr 4.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Neurofibromatosis type 1 (NF1) is a genodermatosis caused by heterozygous germ line variations in the NF1 gene. A second-hit NF1 aberration results in the formation of café-au-lait macules, cutaneous neurofibroma and plexiform neurofibroma (PNF). Mosaic NF1 (mNF1), caused by a postzygotic NF1 mutation, is characterized by localized or generalized NF1-related manifestations. Read More

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http://dx.doi.org/10.1111/1346-8138.15327DOI Listing

Children with malignant melanoma: a single center experience from Turkey.

Turk Pediatri Ars 2020 9;55(1):39-45. Epub 2020 Mar 9.

Department of Pediatric Hematology-Oncology, İstanbul University, Oncology Institute, İstanbul, Turkey.

Aim: Malignant melanoma is the most frequent skin cancer in children and adolescents. It comprises 1-3% of all malignancies. In this study, we aimed to evaluate the clinical aspects, histopathologic features, and treatment outcomes of our patients with malignant melanoma. Read More

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http://dx.doi.org/10.14744/TurkPediatriArs.2019.90022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096563PMC

[Malignant melanoma].

Pathologe 2020 May;41(3):281-292

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

Malignant melanoma is an aggressive skin cancer that originates from cells of the melanocytic lineage and is associated with an invasive growth pattern and early spread. Besides endogenous risk factors such as fair skin type or genetic disposition for the formation of multiple nevi, exposure to ultraviolet light is the most important exogenous risk factor. Treatment of patients with primary tumors includes the complete excision of the primary lesion with appropriate safety margins and in patients with an increased risk of metastasis sentinel lymph node excision. Read More

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http://dx.doi.org/10.1007/s00292-020-00776-xDOI Listing

TERT and TERT promoter in melanocytic neoplasms: Current concepts in pathogenesis, diagnosis, and prognosis.

J Cutan Pathol 2020 Mar 23. Epub 2020 Mar 23.

Laboratorio Recavarren Emanuel, Clínica Ricardo Palma, Lima, Peru.

Background And Objective: Located on chromosome locus 5p15.33, telomerase reverse transcriptase (TERT or hTERT) encodes the catalytic subunit of telomerase which permits lengthening and preservation of telomeres following mitosis. Mutations in TERT promoter (TERT-p) upregulate expression of TERT, allowing survival of malignant cells and tumor progression in wide variety of malignancies including melanoma. Read More

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http://dx.doi.org/10.1111/cup.13691DOI Listing

Malignant melanoma in a child with giant congenital melanocytic nevus and satellite flekers: A rare entity.

Diagn Cytopathol 2020 Jun 17;48(6):564-566. Epub 2020 Mar 17.

Department of Pathology, V.M.M.C and Safdarjung Hospital, New Delhi, India.

Malignant melanomas in the pediatric age are remarkably rare representing 0.9% of various pediatric malignancies. Congenital nevi occur in 1 in 100 newborns, whereas giant congenital melanocytic nevus (GCMN) measuring more than 20 cm is seen in 1 in 20 000 cases. Read More

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http://dx.doi.org/10.1002/dc.24408DOI Listing

Follicular Becker's Nevus: A New Clinical Variant.

Indian J Dermatol 2020 Mar-Apr;65(2):130-132

Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.

Becker's nevus, also known as pigmented hairy epidermal nevus, is characteristically described as a unilateral, hairy, light to dark brown macule with sharply outlined but irregular border. The etiopathogenesis of Becker's nevus is still not clearly understood. Perifollicular pigmentation has been described earlier by some authors. Read More

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http://dx.doi.org/10.4103/ijd.IJD_476_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059461PMC

Risk factors for the development of a second melanoma in patients with cutaneous melanoma.

J Eur Acad Dermatol Venereol 2020 Mar 12. Epub 2020 Mar 12.

School of Medicine, Universidad Católica de Valencia San Vicente Mártir, València, Spain.

Background: Cutaneous melanoma patients have an increased risk of developing other neoplasms, especially cutaneous neoplasms and other melanomas. Identifying factors associated with an increased risk might be useful in the development of melanoma guidelines.

Objectives: To identify risk factors related to the development of a second primary melanoma in a series of patients diagnosed with sporadic melanoma and to establish the estimated incidence rate. Read More

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http://dx.doi.org/10.1111/jdv.16341DOI Listing

Hypophosphatemic rickets: A rare complication of congenital melanocytic nevus syndrome.

Pediatr Dermatol 2020 Mar 10. Epub 2020 Mar 10.

Dermatology and Reference Center for Genodermatoses and Rare Skin Diseases (MAGEC), APHP, Institut Imagine, Hôpital Universitaire Necker-Enfants Malades, Université de Paris, Paris, France.

We report the case of a child who presented with a giant melanocytic nevus with numerous satellite nevi at birth and developed hypophosphatemic rickets due to excessive secretion of the FGF23 hormone. A NRAS c.182A>G (Q61R) mutation was identified in the lesional skin. Read More

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http://dx.doi.org/10.1111/pde.14139DOI Listing

Mutation Signatures in Melanocytic Nevi Reveal Characteristics of Defective DNA Repair.

J Invest Dermatol 2020 Mar 6. Epub 2020 Mar 6.

Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jid.2020.02.021DOI Listing
March 2020
7.216 Impact Factor

A Clinicopathological Study of 29 Spitzoid Melanocytic Lesions With ALK Fusions, Including Novel Fusion Variants, Accompanied by Fluorescence In Situ Hybridization Analysis for Chromosomal Copy Number Changes, and Both TERT Promoter and Next-Generation Sequencing Mutation Analysis.

Am J Dermatopathol 2020 Mar 6. Epub 2020 Mar 6.

Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

ALK-fused spitzoid neoplasms represent a distinctive group of melanocytic lesions. To date, few studies addressed genetic and chromosomal alterations in these lesions beyond the ALK rearrangements. Our objective was to study genetic alterations, including ALK gene fusions, telomerase reverse transcriptase promoter (TERT-p) mutations, chromosomal copy number changes, and mutations in other genes. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001632DOI Listing

Surgical treatment of children and youth with congenital melanocytic nevi: self- and proxy-reported opinions.

Pediatr Surg Int 2020 Apr 3;36(4):501-512. Epub 2020 Mar 3.

Department of Psychosomatics and Psychiatry, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.

Purpose: The role of surgery in the management of congenital melanocytic nevi (CMN) is controversial. Data on surgical outcomes and predictors of satisfaction remain scarce.

Methods: An online survey was employed following worldwide recruitment of youth aged 14-25 years (n = 44) and parents of children ≤ 18 years (n = 249) with CMN to query patterns of treatment and satisfaction with and opinions about the benefits of surgery. Read More

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http://dx.doi.org/10.1007/s00383-020-04633-zDOI Listing

Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma.

Am J Surg Pathol 2020 Jun;44(6):805-816

Departments of Pathology.

Melanocytic tumors with inactivation of protein kinase A regulatory subunit-α (PRKAR1A) have large oval nuclei and intense pigmentation. Historically, these tumors have been categorized under various names, including epithelioid blue nevus, pigmented epithelioid melanocytoma (PEM) and animal-type melanoma. Although a subset of PEM harbor BRAF activating mutations and biallelic inactivation of PRKAR1A, there are only a few reports of melanomas, or of tumors with genomic alterations beyond those of PEMs. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001458DOI Listing

The Importance of Dermoscopy in Early Recognition of Melanoma in Situ.

Curr Health Sci J 2019 Oct-Dec;45(4):366-371. Epub 2019 Dec 30.

Department of Internal Medicine, Medical Center Dr. Ianosi, Craiova, Romania.

Early recognition of melanoma in situ (MIS) is an ongoing challenge in dermatology. It rarely arises 'de novo', most frequently resulting due to the transformation of an atypical nevus. The diagnostic criteria for MIS are diverse dermoscopy being the most used and it has a sensitivity of 83% and a specificity of 69% in detecting melanomas. Read More

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http://dx.doi.org/10.12865/CHSJ.45.04.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014979PMC
December 2019

Nevus-associated melanoma: facts and controversies.

G Ital Dermatol Venereol 2020 Feb;155(1):65-75

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy -

Nevus-associated melanoma (NAM) is defined on histopathological basis by the coexistence of melanoma and nevus components. Melanomas developing on pre-existing congenital or acquired nevi are usually of the superficial spreading subtype and harbor the BRAFV600E mutation. NAM accounts for almost one-third of melanoma cases As compared to de novo melanoma, NAM develops on younger patients, is more frequently located on the trunk, and is associated with a high nevus count, light eye color and history of frequent sunburns. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06534-9DOI Listing
February 2020

Through the looking glass and what you find there: making sense of comparative genomic hybridization and fluorescence in situ hybridization for melanoma diagnosis.

Mod Pathol 2020 Feb 17. Epub 2020 Feb 17.

Departments of Pathology and Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Melanoma is the leading cause of death among cutaneous neoplasms. Best outcome relies on early detection and accurate pathologic diagnosis. For the great majority of melanocytic tumors, histopathologic examination can reliably distinguish nevi from melanomas. Read More

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http://dx.doi.org/10.1038/s41379-020-0490-7DOI Listing
February 2020

DNA copy number changes correlate with clinical behavior in melanocytic neoplasms: proposal of an algorithmic approach.

Mod Pathol 2020 Feb 17. Epub 2020 Feb 17.

Department of Pathology, Michigan Medicine, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USA.

Increasingly, molecular methods are being utilized in the workup of melanocytic neoplasms. To this end, we sought to correlate data from a single nucleotide polymorphism (SNP) array platform based on molecular inversion probes with clinical data. Copy number variation (CNV) data were obtained on 95 melanocytic tumors (6 ordinary nevi, 15 atypical nevi, 34 ambiguous neoplasms, and 40 melanomas) from 92 patients. Read More

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http://dx.doi.org/10.1038/s41379-020-0499-yDOI Listing
February 2020

Neurofibromatosis type 1 and melanoma of the iris arising from a dysplastic nevus: A rare yet casual association?

Eur J Ophthalmol 2020 Feb 16:1120672120906999. Epub 2020 Feb 16.

Laboratorio di Genetica Medica, Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari Aldo Moro, Bari, Italy.

Purpose: We investigated the molecular causes of an unusual pigmented and ulcerated iris lesion detected in a patient diagnosed with neurofibromatosis type 1 (NF1).

Case Report: A 52-year-old man was referred to our clinic with a non-traumatic ulcer in his left eye. Hyphema reabsorption disclosed a pigmented iris mass, thus ultrasound biomicroscopy and anterior segment fluorescein angiography were performed to investigate for the presence of a malignant lesion. Read More

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http://dx.doi.org/10.1177/1120672120906999DOI Listing
February 2020

The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.

Arch Pathol Lab Med 2020 Apr 14;144(4):500-522. Epub 2020 Feb 14.

From the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia (Dr Elder); the Department of Dermatology, University of California San Francisco, San Francisco (Dr Bastian); International Agency for Research on Cancer, Lyon, France (Dr Cree); Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy (Dr Massi); and the Department of Pathology and Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia (Dr Scolyer).

Context.—: There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2019-0561-RADOI Listing

Giant Congenital Melanocytic Nevi Successfully Treated with Combined Laser Therapy.

Indian Dermatol Online J 2020 Jan-Feb;11(1):79-82. Epub 2020 Jan 13.

Department of Dermatology. Sakhiya Skin Clinic PVT LTD, Surat, Gujarat, India.

Congenital melanocytic nevi are benign proliferations of cutaneous melanocytes that arise as a result of abnormal growth, development, or migration of melanoblasts. Clinically, the giant congenital nevus is greater than 20 cm in size, pigmented and often hairy. The risk of malignant melanoma for the giant nevi is almost 6%. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_107_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001409PMC
January 2020

Retrospective photographic review of nontattoo indications treated by picosecond laser.

J Cosmet Dermatol 2020 Mar;19(3):612-621

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Picosecond (PS) lasers were approved by the US FDA in 2012 after being shown to remove tattoos with more success and fewer treatments compared with traditional methods. PS lasers were shown to be versatile, indicated for the treatment of lentigines, café-au-lait macules (CALMs), and acne scars and skin rejuvenation.

Objective: We report our experience treating our patients for different indications using a PS laser. Read More

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http://dx.doi.org/10.1111/jocd.13285DOI Listing

SERINE-910 Phosphorylated Focal Adhesion Kinase Expression Predicts Better Overall and Disease-free Survival in Melanoma.

Appl Immunohistochem Mol Morphol 2020 02;28(2):130-138

Department of Pathology, Albany Medical College, MC-81, Albany, NY.

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that mediates multiple cellular functions such as survival, invasion, and migration. FAK has been found to be over-expressed in various human cancers, including melanoma. FAK molecule has several tyrosine, serine, and threonine phosphorylation sites which have an important regulatory role. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000744DOI Listing
February 2020