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    Clinical course, treatment modalities, and quality of life in patients with congenital melanocytic nevi - data from the German CMN registry.
    J Dtsch Dermatol Ges 2017 Feb;15(2):159-167
    Department of Dermatology, University of Lübeck, Germany.
    Background: Congenital melanocytic nevi (CMN) are associated with mental stress as well as medical risks for those affected. The German CMN registry was initiated in 2005. Herein, we present results from an interim analysis focusing on disease course, treatment modalities, and quality of life. Read More

    Reasons for rarity of anal melanocytic naevi.
    Australas J Dermatol 2017 Feb 17. Epub 2017 Feb 17.
    Central Medical Laboratory, Manama, Kingdom of Bahrain.
    In the last 16 years only seven definite cases of anal melanocytic naevi have been reported in the literature. We describe three new cases, none of which were suspected clinically and were incidentally diagnosed on histological examination of haemorrhoidectomy specimens. The infrequency of these special site flexural melanocytic lesions may be related to changes in the involutionary mechanisms of the anal melanocyte proliferation. Read More

    Common Skin Conditions in Children: Congenital Melanocytic Nevi and Infantile Hemangiomas.
    FP Essent 2017 Feb;453:33-37
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Congenital melanocytic nevi (CMN) are hamartomas present at birth that are composed of nevomelanocytes and thought to originate from faulty migration of precursor melanocytes in the neural crest. Classification is based on projected adult size of the lesion. CMN size correlates positively with risk of melanoma and neurocutaneous melanocytosis. Read More

    Combined in vivo reflectance confocal microscopy and digital dermoscopy for follow up of patients at high risk of malignant melanoma: A prospective case series study.
    J Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatology, University Hospital Fundación Alcorcón, Rey Juan Carlos University, Madrid, Spain.
    Digital dermoscopy (DD) follow up is a useful strategy for monitoring patients at high risk of melanoma. Reflectance confocal microscopy (RCM) is a valuable second-level examination after dermoscopy for the evaluation of difficult to diagnose lesions. The aim of this study was to assess the value of RCM in routine DD monitoring of patients at high risk of melanoma. Read More

    Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas.
    Mod Pathol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
    We performed exome sequencing of 77 melanocytic specimens composed of Spitz nevi (n=29), Spitzoid melanomas (n=27), and benign melanocytic nevi (n=21), and compared the results with published melanoma sequencing data. Our study highlights the prominent similarity between Spitzoid and conventional melanomas with similar copy number changes and high and equal numbers of ultraviolet-induced coding mutations affecting similar driver genes. Mutations in MEN1, PRKAR1A, and DNMT3A in Spitzoid melanomas may indicate involvement of the protein kinase A pathway, or a role of DNA methylation in the disease. Read More

    Melanocytic nevus count and dermoscopic features do not differ in psoriatic patients undergoing biological agent versus conventional drug therapy.
    G Ital Dermatol Venereol 2017 Apr;152(2):126-131
    Department of Dermatology and Venereology, Faculty of Medicine, Bezmialem Vakif University Hospital, İstanbul, Turkey.
    Background: Psoriasis is a chronic immune-mediated disease and treatment of psoriasis includes conventional immunosuppressive agents and biological agents. There are a few data on the relationship between psoriasis and melanocytic lesions. Either benign or malignant proliferations may be seen with immunosuppressive treatment. Read More

    Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.
    Exp Mol Pathol 2017 Feb 1;102(2):198-202. Epub 2017 Feb 1.
    Department of Pathology, Division of Neuropathology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, United States. Electronic address:
    Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers in 11 conjunctival nevi, 10 primary acquired melanosis (PAM) lesions, and 11 conjunctival melanomas. Immunostains included the melanocytic markers HMB-45 and Melan-A, as well as the proliferative marker Ki-67. Read More

    Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes.
    Curr Opin Ophthalmol 2017 Jan 30. Epub 2017 Jan 30.
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
    Purpose Of Review: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus.

    Recent Findings: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. Read More

    Polypoid Spitz Nevus With a Halo Reaction.
    Am J Dermatopathol 2017 Feb;39(2):130-133
    *Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain;†Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, INER/CIENI, Hospital Angeles Lomas, Centro Medico ABC, Mexico City, Mexico; and‡Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense, I+12, Madrid, Spain.
    Approximately, 2% of Spitz nevi are polypoid; between 3.6% and 7.4% present with a halo reaction. Read More

    CLINICAL PROFILE AND TRIGGERING FACTORS FOR ACQUIRED, BILATERAL NEVUS OF OTA-LIKE MACULES.
    Cutan Ocul Toxicol 2017 Jan 25:1-14. Epub 2017 Jan 25.
    a Affiliated Hospital of Nanjing University of Chinese Medicine , Nanjing , China.
    BACKGROUD Acquired, bilateral nevus of Ota-like macules (ABNOM) is one of the most common dermal melanocytoses. Although there are some literatures on ABNOM, its clinical features and etiopathogenetic factors have not been fully understood. OBJECTIVE To determine the prevalence and characteristics of ABNOM among the Chinese patients. Read More

    Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance.
    Lab Invest 2017 Jan 16. Epub 2017 Jan 16.
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
    Melanocytes, a neural crest cell derivative, produce pigment to protect keratinocytes from ultraviolet radiation (UVR). Although melanocytic lesions such as nevi and cutaneous malignant melanomas are known to be associated with sun exposure, the role of UVR in oncogenesis is complex and has yet to be clearly elucidated. UVR appears to have a direct mutational role in inducing or promoting melanoma formation as well as an indirect role through microenvironmental changes. Read More

    Case Report of a Large Pigmented Epithelioid Melanocytoma With Suspected Lymph Node Metastases.
    Eplasty 2016 16;16:e33. Epub 2016 Dec 16.
    Departments of Plastic and Reconstructive Surgery, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Objective: Pigmented epithelioid melanocytoma was proposed by Zembowicz et al in 2004 including lesions previously diagnosed as human animal-type melanoma and epithelioid blue nevus. Tumors are composed of epithelioid and spindled melanocytes with heavy pigmentation. Methods: We report a case of pigmented epithelioid melanocytoma in 47-year-old Asian woman. Read More

    Nevus Spilus (Speckled Lentiginous Nevus) in the Oral Cavity: Report of a Case and Review of the Literature.
    Am J Dermatopathol 2017 Jan;39(1):e8-e12
    *Department of Oral and Maxillofacial Pathology, Naval Postgraduate Dental School, Bethesda, MD; and †Department of Pathology, Walter Reed National Medical Military Center, Bethesda, MD.
    The congenital melanocytic nevus is a pigmented melanocytic lesion that presents at birth or shortly thereafter. It is commonly described on the skin, usually on the trunk and extremities. Only five intraoral cases of congenital melanocytic nevi have been described in the English literature. Read More

    Differentiated squamous intraepithelial lesion (dSIL)-like changes in the epidermis overlying anogenital melanocytic nevi: A diagnostic pitfall.
    Ann Diagn Pathol 2017 Feb 14;26:43-46. Epub 2016 Nov 14.
    Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
    Background: Differentiated squamous intraepithelial lesion (dSIL) is morphologically and immunohistochemically analogous in the whole anogenital region. dSIL is a premalignant lesion frequently misinterpreted histopathologically as a benign dermatosis. The authors describe a peculiar change in the basal cell layer of the epidermis/epithelium overlying anogenital melanocytic nevi that may histopathologically imitate dSIL. Read More

    Malignant Melanoma in Association With a Thymic Nevus in a Patient With a Giant Congenital Nevus.
    Am J Dermatopathol 2016 Dec 28. Epub 2016 Dec 28.
    *Institute of Pathology, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel; †Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; ‡Department of Oncology, Soroka Medical Center, Beer Sheva, Israel; §Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel; ¶Institute of Pathology, Soroka Medical Center, Beer Sheva, Israel; and ‖Department of Cardiothoracic Surgery, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel.
    Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. Read More

    5-Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms.
    J Cutan Pathol 2017 Mar 6;44(3):249-255. Epub 2017 Feb 6.
    Program in Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Background: 5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker detectable through immunohistochemistry (IHC) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity. The purpose of the study was to explore its diagnostic utility in a subset of histologically challenging, heavily pigmented cutaneous melanocytic neoplasms.

    Methods: 5-hmC IHC was performed on 54 heavily pigmented melanocytic tumors. Read More

    Evaluation of tubulin β-3 as a novel senescence-associated gene in melanocytic malignant transformation.
    Pigment Cell Melanoma Res 2016 Dec 26. Epub 2016 Dec 26.
    Experimental Pathology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Malignant melanoma might develop from melanocytic nevi in which the growth-arrested state has been broken. We analyzed the gene expression of young and senescent human melanocytes in culture and compared the gene expression data with a dataset from nevi and melanomas. A concordant altered gene expression was identified in 84 genes when comparing the growth-arrested samples with proliferating samples. Read More

    Comparative study of presurgical skin infiltration depth measurements of melanocytic lesions with OCT and high frequency ultrasound.
    J Biophotonics 2016 Dec 23. Epub 2016 Dec 23.
    Hannoversches Zentrum für Optische Technologien (HOT), Leibniz Universität Hannover, Nienburger Str. 17, 30167, Hannover, Germany.
    A reliable, fast, and non-invasive determination of melanoma thickness in vivo is highly desirable for clinical dermatology as it may facilitate the identification of surgical melanoma margins, determine if a sentinel node biopsy should be performed or not, and reduce the number of surgical interventions for patients. In this work, optical coherence tomography (OCT) and high frequency ultrasound (HFUS) are evaluated for quantitative in vivo preoperative assessment of the skin infiltration depth of melanocytic tissue. Both methods allow non-invasive imaging of skin at similar axial resolution. Read More

    Antiproliferative and Pro-Apoptotic Effects of MiR-4286 Inhibition in Melanoma Cells.
    PLoS One 2016 22;11(12):e0168229. Epub 2016 Dec 22.
    Department of Pathophysiology, Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation.
    Introduction: MicroRNAs are essential regulators of gene expression at the post-transcriptional level. Their expression is altered in cancer tissues, and evaluation of these alterations is considered a promising tool used to diagnose and identify prognostic markers.

    Materials And Methods: The microRNA expression profiles of formalin-fixed, paraffin-embedded melanoma and melanocytic nevi samples were estimated with a microarray and subsequently validated by real-time PCR. Read More

    IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T Cell Subpopulations.
    J Immunol 2017 Jan 21;198(2):950-961. Epub 2016 Dec 21.
    Department of Dermatology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294; and
    In animal models, IL-12 and IL-23 participate in the development of malignant neoplasms of keratinocytes. However, the role of these cytokines in pigmented lesion development and their progression to melanoma has received little attention. IL-12p35, IL-23p19, and IL-12/IL-23p40 knockout mice on a C3H/HeN background, subjected to a melanomagenesis protocol, demonstrated profound differences in susceptibility to nevus initiation, transformation, tumorigenicity, and metastatic potential. Read More

    Attenuation of genome-wide 5-methylcytosine level is an epigenetic feature of cutaneous malignant melanomas.
    Melanoma Res 2016 Dec 16. Epub 2016 Dec 16.
    Departments of aPathology bDermatology, Yale University, New Haven, Connecticut Departments of cPathology dDermatology eOncology, The Johns Hopkins University School of Medicine fSidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.
    Epigenetic modification of DNA, namely covalent changes of cytosine residues, plays a key role in the maintenance of inactive chromatin regions, both in health and in disease. In the vast majority of malignant melanomas, the most notable known epigenetic abnormality is the attenuation of 5-hydroxymethylcytosine (5-hmC) residues. However, it remains unknown whether a decrease in 5-hmC represents a primary defect of melanoma cancer epigenome or whether it is secondary to the loss of 5-methylcytosine (5-mC), a chemical substrate for 5-hmC. Read More

    Study protocol for a prospective, non-controlled, multicentre clinical study to evaluate the diagnostic accuracy of a stepwise two-photon excited melanin fluorescence in pigmented lesions suspicious for melanoma (FLIMMA study).
    BMJ Open 2016 Dec 19;6(12):e012730. Epub 2016 Dec 19.
    Department of Dermatology, University of Heidelberg, Germany.
    Introduction: Non-invasive, nanosecond, stepwise two-photon laser excitation of skin tissue was shown to induce melanin fluorescence spectra that allow for the differentiation of melanocytic nevi from cutaneous melanoma.

    Methods And Analysis: This prospective, non-controlled, multicentre clinical study is performed to evaluate the diagnostic performance of the stepwise two-photon excited melanin fluorescence in the detection of cutaneous melanoma. The comparator will be the histopathological diagnosis. Read More

    TRPM1 (melastatin) expression is an independent predictor of overall survival in clinical AJCC stage I and II melanoma patients.
    J Cutan Pathol 2016 Dec 17. Epub 2016 Dec 17.
    Department of Pathology, Albany Medical College MC-81, Albany, New York.
    Background: The expression of TRPM1 (melastatin) mRNA is an independent marker, as measured by radioactive in situ hybridization (RISH), of disease-free survival in primary cutaneous melanoma (PM). The aim of the study was to determine if chromogenic in situ hybridization (CISH) can reproduce results examining diagnostic and prognostic utility of TRPM1 mRNA expression in melanocytic proliferations as measured by RISH.

    Methods: The expression of TRPM1 mRNA was detected by CISH in melanocytic nevi (MN, n = 61), PM (n = 145) and metastatic melanomas (MMs, n = 15). Read More

    Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi.
    Mod Pathol 2016 Dec 9. Epub 2016 Dec 9.
    Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
    Blue nevi are common melanocytic tumors arising in the dermal layer of the skin. Similar to uveal melanomas, blue nevi frequently harbor GNAQ and GNA11 mutations. Recently, recurrent CYSLTR2 and PLCB4 mutations were identified in uveal melanomas not harboring GNAQ or GNA11 mutations. Read More

    Pigmentation and Pregnancy: Knowing What Is Normal.
    Obstet Gynecol 2017 Jan;129(1):168-173
    Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York; the Department of Dermatology, University of Connecticut, Farmington, Connecticut; and the Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland.
    Changes in melanocytic nevi during pregnancy are frequently attributed to the new hormonal milieu and are dismissed without concern for malignancy. Recent studies suggest that pregnancy itself does not induce significant change in nevi, and delays in the assessment of changing moles may contribute to the often more advanced nature of melanomas diagnosed during or soon after pregnancy. Nevi on the breasts and abdomen can grow as a result of skin expansion, but studies have found no significant changes in nevi located in more stable areas such as the back or lower extremities. Read More

    A Phase II Randomized Placebo-Controlled Trial of Oral N-acetylcysteine for Protection of Melanocytic Nevi against UV-Induced Oxidative Stress In Vivo.
    Cancer Prev Res (Phila) 2017 Jan 5;10(1):36-44. Epub 2016 Dec 5.
    Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.
    Oxidative stress plays a role in UV-induced melanoma, which may arise from melanocytic nevi. We investigated whether oral administration of the antioxidant N-acetylcysteine (NAC) could protect nevi from oxidative stress in vivo in the setting of acute UV exposure. The minimal erythemal dose (MED) was determined for 100 patients at increased risk for melanoma. Read More

    Combination therapy in skin of color including injectables, laser, and light devices.
    Semin Cutan Med Surg 2016 Dec;35(4):211-217
    Goldman, Butterwick, Groff, Fabi & Wu, Cosmetic Laser Dermatology, San Diego, California, USA.
    With the rapid increase in patients seeking cosmetic treatments, the variation in responses of lightly pigmented skin versus darkly pigmented skin has become increasingly apparent. Despite extensive treatment options in patients with skin of color, there is a paucity of well-designed studies performed on this patient population. The lack of research is concerning, as it is well documented that patients with darker skin types are at an increased risk of adverse events when treated with many of the available modalities used in cosmetic procedures. Read More

    Associations between benign cutaneous nevi and risk of Type 2 diabetes mellitus in men and women: results from two prospective cohort studies.
    Diabet Med 2016 Dec 5. Epub 2016 Dec 5.
    Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN.
    Aim: To examine the association of cutaneous nevi with Type 2 diabetes risk.

    Methods: We prospectivly examined the associations between nevus count and risk of Type 2 diabetes among 26 240 men (1988-2010) from the Health Professionals Follow-up Study and 67 050 women (1986-2010) from the Nurses' Health Study. Information on the numbers of cutaneous nevi on arms at baseline and incident cases of Type 2 diabetes was collected using validated questionnaires. Read More

    Pigmented oral compound nevus of retromolar area - A rare case report.
    Singapore Dent J 2016 Dec;37:33-35
    Department of Oral Pathology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi. Electronic address:
    Solitary pigmented melanocytic intraoral lesions of the oral cavity are rare. Oral nevus is a congenital or acquired benign neoplasm. Oral compound nevus constitutes 5. Read More

    The Relationship of Psoriasis and Melanocytic Nevi.
    Indian J Dermatol 2016 Nov-Dec;61(6):664-667
    Department of Dermatology, Bezmialem Vakif University, Istanbul, Turkey.
    Background: There is limited data about the relationship between psoriasis and melanocytic lesions and melanoma. Immunologic pathways which were implicated in psoriasis induce a reduction in the number of melanocytic nevi.

    Aims And Objectives: To investigate the number of melanocytic nevi in psoriatic patients compared with controls and its relationship with disease severity and type of treatment. Read More

    Prognostic significance of the expression of nuclear eukaryotic translation initiation factor 5A2 in human melanoma.
    Oncol Lett 2016 Nov 29;12(5):3089-3100. Epub 2016 Aug 29.
    Department of Surgery, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z 1L8, Canada.
    Eukaryotic translation initiation factor 5A2 (EIF5A2) expression is upregulated in various cancers. The present authors previously demonstrated that cytoplasmic EIF5A2 expression increases with melanoma progression and inversely correlates with patient survival. Other studies have suggested that nuclear EIF5A2 may also play a role in oncogenesis. Read More

    Tissue Expansion in Children.
    Semin Plast Surg 2016 Nov;30(4):155-161
    Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas.
    Tissue expansion is a well-established surgical method that has been creatively applied to the management of many congenital and acquired pediatric conditions, including the removal of giant congenital melanocytic nevi and the separation of conjoined twins. Careful preoperative planning and patient follow-up are required to achieve the proper results and minimize complications. Special considerations for pediatric patients are present during each step of the process, from patient selection to postoperative care. Read More

    Pre-expanded Paraumbilical Perforator Flap.
    Clin Plast Surg 2017 Jan 4;44(1):99-108. Epub 2016 Oct 4.
    Department of Plastic and Reconstructive Surgery, Plastic Surgery Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Ba-Da-Chu Road 33#, Beijing 100144, P.R. China.
    The paraumbilical perforator flap is the first and the most famous perforator flap. Pre-expansion increases the flap dimension and reduces the flap thickness and donor site morbidities, making the paraumbilical perforator flap a more effective option for upper extremity reconstruction. Pre-expanded pedicled paraumbilical perforator flaps can achieve excellent function and aesthetic outcomes in patients with extensive scar contracture and giant melanocytic nevi in the upper extremity. Read More

    An Overview of Pre-expanded Perforator Flaps: Part 2, Clinical Applications.
    Clin Plast Surg 2017 Jan;44(1):13-20
    Division of Plastic Surgery, University of California Davis Medical Center, 2221 Stockton Boulevard, Suite 2123, Sacramento, CA 95817, USA. Electronic address:
    Pre-expanded perforator flaps have several advantages over their traditional counterparts owing to the thin, more pliable nature, larger size, and minimum morbidity of the donor site. Recently, plastic surgeons have begun to use pre-expanded perforator flaps to reconstruct defects of almost the entire body, including the cervicofacial region, axilla, trunk, and extremities resulting from scar, congenital melanocytic nevi, hemangiomas, and neurofibromas. Such a versatile flap is especially appropriate for face and neck resurfacing, which requires more optimal functional and cosmetic outcomes. Read More

    Genomic Characterization of Dysplastic Nevi Unveils Implications for Diagnosis of Melanoma.
    J Invest Dermatol 2016 Nov 24. Epub 2016 Nov 24.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
    A well-defined risk factor and precursor for cutaneous melanoma is the dysplastic nevus. These benign tumors represent clonal hyperproliferation of melanocytes that are in a senescent-like state, but with occasional malignant transformation events. To portray the mutational repertoire of dysplastic nevi in patients with the dysplastic nevus syndrome and to determine the discriminatory profiles of melanocytic nevi (including dysplastic nevi) from melanoma, we sequenced exomes of melanocytic nevi including dysplastic nevi (n = 19), followed by a targeted gene panel (785 genes) characterization of melanocytic nevi (n = 46) and primary melanomas (n = 42). Read More

    Melanocytic Nevi and the Genetic and Epigenetic Control of Oncogene-Induced Senescence.
    Dermatol Clin 2017 Jan;35(1):85-93
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA; Research & Development Service, VA Maryland Health Care System, Baltimore, MD, 21201, USA; Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:
    Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senescence should help identify pathways underlying melanoma development, leading to the development of new strategies for melanoma prevention and early detection. Read More

    Adipophilin expression in cutaneous malignant melanoma.
    J Cutan Pathol 2017 Mar 22;44(3):228-236. Epub 2016 Dec 22.
    Department of Diagnostic Pathology, Wakayama Medical University, Wakayama, Japan.
    Background: The lipogenic pathway is upregulated in cancer cells, including melanomas. However, the pathological significance of cellular lipids in melanocytic lesions has yet to be determined. In this study, we evaluated intracytoplasmic lipid droplets in melanocytic nevi (MNs) and malignant melanomas via immunohistochemical analysis of adipophilin (ADP), which coats lipid droplets. Read More

    Number and size of acquired melanocytic nevi and affecting risk factors in cases admitted to the dermatology clinic.
    Postepy Dermatol Alergol 2016 Oct 21;33(5):375-380. Epub 2016 Oct 21.
    Dermatology Clinic, School of Medicine, Balıkesir University, Balıkesir, Turkey.
    Introduction: The size and number of acquired melanocytic nevi (AMN) and presence of dysplastic nevi are the leading risk factors that should be recognized in the development of malignant melanoma.

    Aim: To evaluate AMN and risk factors in the development of AMN in all age groups admitted to a dermatology outpatient clinic.

    Material And Methods: Four hundred and twelve patients who were admitted to the dermatology outpatient clinic for any dermatological symptom and who accepted to participate in the study were randomly included in the study. Read More

    Spitz Nevi and Other Spitzoid Neoplasms in Children: Overview of Incidence Data and Diagnostic Criteria.
    Pediatr Dermatol 2017 Jan 22;34(1):25-32. Epub 2016 Nov 22.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. Read More

    Melanocytic Nevi of Special Sites.
    Am J Dermatopathol 2016 Dec;38(12):867-881
    *Resident, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC; †Dermatologist, International Dermatopathology Fellow, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC; and ‡Professor of Pathology and Dermatology, Director of Dermatopathology, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC.
    Melanocytic nevi located on specific regions of the body can demonstrate unusual histopathological features such as asymmetry, irregular nesting patterns, pagetoid spread, cytologic atypia, and rarely, mitotic activity. However, despite these features that may raise concern for malignant melanoma, these lesions follow a benign clinical course and do not require intervention. Also known as nevi of special sites or nevi with site-related atypia, these melanocytic nevi were initially described on acral sites and genitalia. Read More

    Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions.
    Dermatol Pract Concept 2016 Oct 31;6(4):1-6. Epub 2016 Oct 31.
    Department of Dermatology and Venereology, Sahlgrenska University Hospital and Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Background: Early detection of melanoma is vital for treatment outcome and survival. Short-term sequential digital dermoscopic monitoring (ST-SDDM) involves the capture and assessment of dermoscopic images of one or more atypical melanocytic lesions (AMLs), at baseline and after four months, in order to detect early morphologic changes. Electrical impedance spectroscopy (EIS) is a diagnostic tool with high sensitivity for the detection of malignant melanocytic lesions. Read More

    Significance of epidermal mitoses in challenging melanocytic proliferations.
    J Cutan Pathol 2017 Feb 15;44(2):135-143. Epub 2016 Dec 15.
    Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.
    Background: Accurate diagnosis of melanoma remains histologically challenging. Dermal mitoses support malignancy, but are only occasionally seen in melanomas. As melanomagenesis is thought to begin at the dermal-epidermal junction, we investigated the significance of epidermal melanocytic mitoses (EMM) in a spectrum of lesions with molecular characterization. Read More

    BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION ASSOCIATED WITH RENAL CANCER: THE IMPORTANCE OF INDOCYANINE GREEN ANGIOGRAPHY AND EARLY DIAGNOSIS.
    Retin Cases Brief Rep 2016 Nov 17. Epub 2016 Nov 17.
    *Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; †Department of Ophthalmology, Brazilian Institute of Fight Against Blindness, Assis and Presidente Prudente, São Paulo, Brazil; and ‡Department of Oncology, Hospital Fundação Amaral Carvalho, Jaú, São Paulo, Brazil.
    Purpose: To report a case of bilateral diffuse uveal melanocytic proliferation associated with renal carcinoma and to illustrate the importance of ancillary examinations to early diagnosis and treatment.

    Design: Clinical case report.

    Methods: A 56-year-old man reported a 3-day history of visual impairment and scotoma in the right eye. Read More

    Spitz nevi: diverse clinical, dermatoscopic and histopathological features in childhood.
    J Dtsch Dermatol Ges 2017 Jan 10;15(1):70-75. Epub 2016 Nov 10.
    Dermatology, Department of -Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
    Background And Objectives: The characterization of clinical features and biological potential of Spitz nevi has attracted a lot of interest in past decades. The aim of our paper was to describe the clinical, dermatoscopic features as well as the clinical outcome of surgically excised Spitz nevi in three different pediatric age groups.

    Patients And Methods: A retrospective study analyzing clinical features, videodermatoscopic images, histopathological diagnosis and patient outcome. Read More

    Giant melanocytic nevi with neurocutaneous melanosis masquerading as neurofibromas.
    J Pediatr Neurosci 2016 Jul-Sep;11(3):258-260
    Department of Neuroradiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
    Neurocutaneous melanosis is congenital melanocytic nevus with neurological manifestations. We report a 4-year-old female child presenting with hyperpigmented and nodular skin lesion associated with developmental delay and convulsions. The child had multiple brownish-black nevi on the face and chest and giant melanocytic nevi on thoraco-abdomen, back, and gluteal region. Read More

    Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors.
    Ophthalmology 2017 Feb 14;124(2):197-204. Epub 2016 Nov 14.
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon. Electronic address:
    Purpose: To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions.

    Design: Cross-sectional observational clinical study.

    Participants: Patients with iris lesions and healthy volunteers. Read More

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