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    1943 results match your criteria Neutrophilic Eccrine Hidradenitis

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    Patients with hidradenitis suppurativa have a high psychiatric disease burden: A Finnish nationwide registry study.
    J Invest Dermatol 2017 Jul 20. Epub 2017 Jul 20.
    PEDEGO Research Unit, University of Oulu; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland. Electronic address:
    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of hair follicles which is associated with various comorbidities. In order further to clarify the associations between HS and psychiatric disorders, we conducted a nationwide retrospective study that included 4381 patients with HS and 39554 psoriasis and 43248 melanocytic nevi patients as controls. Patient data were obtained from the statutory Finnish Care Register for Health Care. Read More

    Inflammatory Joint Disorders and Neutrophilic Dermatoses: a Comprehensive Review.
    Clin Rev Allergy Immunol 2017 Jul 22. Epub 2017 Jul 22.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Unità Operativa di Dermatologia, Università degli Studi di Milano, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
    Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and psoriasis, and rare diseases like neutrophilic dermatoses. The latter are clinically characterised by polymorphic lesions, including pustules, bullae, abscesses, papules, nodules, plaques and ulcers, and histologically by neutrophil-rich inflammatory infiltrates. Read More

    A pilot study of fatigue in patients with Hidradenitis suppurativa.
    Br J Dermatol 2017 Jul 22. Epub 2017 Jul 22.
    Zealand University Hospital, Department of Dermatology, Roskilde, Denmark.
    Patients suffering from Hidradenitis Suppurativa often complain of fatigue or tiredness, a common symptom in other chronic systemic inflammatory conditions.(1) Fatigue has been reported as a prodromal symptom in 32% of HS patients(1) , indicating that it is an important symptom in HS. This article is protected by copyright. Read More

    Hidradenitis Suppurativa in Children Treated with Finasteride-A Case Series.
    Pediatr Dermatol 2017 Jul 20. Epub 2017 Jul 20.
    Department of Dermatology, Centro Hospitalar do Porto, Porto, Portugal.
    Background: Hidradenitis suppurativa (HS) is rare in childhood, with only 2% of cases in patients younger than 11 years. It is a chronic, recurrent, debilitating condition for which no universally effective treatment has been developed. We present five cases of children with HS diagnosed between the ages of 6 and 11 years. Read More

    [Hidradenitis suppurativa - symptoms, diagnostics, and therapy].
    Cas Lek Cesk 2017 ;156(3):127-132
    Hidradenitis suppurativa is a chronic skin disorder characterized by recurrent inflammatory nodules, fistulas, abscesses, and scarring mainly in the intertriginous areas with terminal hair and apocrine glands. Hidradenitis suppurativa manifests usually after puberty, in the third life decade and persists for many years. The prevalence of the disease is estimated to be 0,5 % in the Czech Republic. Read More

    Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
    Br J Dermatol 2017 Jul 18. Epub 2017 Jul 18.
    Universidade do Porto Ringgold Standard Institution - EpiUnit, Institute of Public Health, Porto, Portugal.
    Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating skin disease of the hair follicle that is accompanied by systemic inflammation. Treating HS is challenging, and therapeutic tools as diverse as topical and systemic antibiotics, biologics, intralesional steroids, surgical procedures or light and laser therapies are frequently needed. The combination of oral clindamycin and rifampicin (R+C) has been suggested as a possible treatment regimen (level of evidence III, strength of recommendation C). Read More

    Considering the impact of pregnancy on the natural history of hidradenitis suppurativa.
    Br J Dermatol 2017 Jul 18. Epub 2017 Jul 18.
    Johns Hopkins Medical Institutions, Department of Dermatology.
    Hidradenitis suppurativa (HS) is a chronic and debilitating inflammatory skin disease that disproportionately affects women of childbearing age. Yet, little has been written about the impact of pregnancy on the natural history of HS. It has been postulated that apocrine-gland activity diminishes in pregnancy, accounting for symptom remission. Read More

    Clinical and histological changes in Hidradenitis suppurativa following 1064 nm nd:YAG intralesional laser treatment.
    J Biol Regul Homeost Agents 2017 07 13;31(2 Suppl. 2). Epub 2017 Jul 13.
    Anatomic Pathologic, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
    Hidradenitis Suppurativa (HS) is recently attracting much attention and awareness, often because it is misdiagnosed for years, restricting the therapeutic options. Moreover, this pathology arises in areas such as the inguinal region, that may cause embarrassment in young patients. Wrong diagnosis and delay in appropriate treatments lead to an exacerbation of the symptoms and a progression of the disease, which at the last stage can only be managed through extensive surgical excisions, ablation and vaporization of nodules with CO2 laser systems or aggressive chemotherapies such as anti-TNF-alpha like adalimumab (Humira®-AbbVie Inc. Read More

    Recognizing Syndromic Hidradenitis Suppurativa: a review of the literature.
    J Eur Acad Dermatol Venereol 2017 Jul 11. Epub 2017 Jul 11.
    Department of Dermatology, Zealand University Hospital, Roskilde; Health Sciences Faculty, University of Copenhagen, Denmark.
    Background: Hidradenitis suppurativa (HS) is an inflammatory skin disease causing painful inflammation and suppuration. It may occur in rare syndromes: follicular occlusion, Bazex-Dupré-Christol, Down's, KID, PAPASH, PASS, PASH, and SAPHO syndromes, as well as Dowling-Degos disease. An overview of syndromic HS may inform the search for etiological factors in HS. Read More

    Swiss Practice Recommendations for the Management of Hidradenitis Suppurativa/Acne Inversa.
    Dermatology 2017 Jul 7. Epub 2017 Jul 7.
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Hidradenitis suppurativa (HS) is a painful, inflammatory, debilitating skin disease with a chronic intermittent course. The central pathogenetic event seems to be the occlusion of the hair follicle. HS has a 1-year prevalence of about 1%. Read More

    Serum Anticytokine Autoantibody Levels Are Not Increased in Hidradenitis Suppurativa: A Case-Control Pilot Study.
    Dermatology 2017 Jul 4. Epub 2017 Jul 4.
    Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
    Background: Hidradenitis suppurativa is a skin disease of recurrent episodes of inflammatory nodules, abscesses, and scarring of the intertriginous regions, e.g. the axillae and groin. Read More

    European Heart SCORE may underestimates cardiovascular risk after assessing cardiovascular disease with carotid ultrasound in Hidradenitis Suppurativa.
    Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.
    Department of Dermatology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain.
    Hidradenitis suppurativa (HS) is chronic recurrent inflammatory disease affecting intertriginous areas, especially the axilla and the groin(1) . It is characterized by painful, deep-seated, inflamed lesions, including nodules, abscesses, and sinus tracts(2) . A recent meta-analysis found an association between HS and traditional cardiovascular (CV) risk factors and metabolic syndrome(3) . Read More

    Hidradenitis Suppurativa and electrocardiographic changes - a cross-sectional population study.
    Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.
    Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.
    Background: Hidradenitis Suppurativa (HS) is a chronic, inflammatory skin disease, recently associated with metabolic syndrome, subclinical atherosclerosis and increased risk of cardiovascular disease.

    Objectives: The aim of the study was to investigate the hitherto unknown electrocardiographic changes associated with HS, which recently have been associated with significant cardiovascular burden.

    Methods: Data were derived from the cross-sectional population study, The Danish General Population Study (GESUS). Read More

    Prevalence of Hidradenitis Suppurativa Among Patients with Down Syndrome: a population based cross sectional analysis.
    Br J Dermatol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, NY.
    Background: Hidradenitis Suppurativa (HS) has been linked to Down syndrome (DS).

    Objective: To determine whether Down syndrome patients have a higher prevalence of HS, and whether diagnosis of HS occurs at an earlier age.

    Methods: Cross-sectional analysis in a population sample of 11,936 DS patients and 16,813,290 non-DS patients. Read More

    The critical role of macrophages in the pathogenesis of hidradenitis suppurativa.
    Inflamm Res 2017 Jun 27. Epub 2017 Jun 27.
    Faculty of Medicine, University of Toronto, Toronto, Canada.
    Introduction: Hidradenitis suppurativa (HS) is a painful chronic inflammatory disease with a prevalence between 1 and 4% of general population. The pathogenesis of HS long eluded scientists, but growing evidence suggests that it is a consequence of inflammatory dysregulation.

    Findings: Recent studies suggest that dysregulated immune response to skin flora and overexpression of inflammatory cytokines leads to chronic skin inflammation seen in HS. Read More

    Severe hidradenitis suppurativa responding to treatment with secukinumab: a case report.
    Br J Dermatol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Dermatology, Zealand University Hospital, Roskilde; Health Sciences Faculty, University of Copenhagen, Denmark.
    An inappropriate immunologic response to an unknown antigen has been suggested to play a role in the pathogenesis of Hidradenitis suppurativa (HS). Studies have identified elevated levels of several proinflammatory cytokines, including IL-17A and TNF-α, nominating these as possible therapeutic targets.(1) Secukinumab is an Il-17A monoclonal antibody, which binds to Il-17A and inhibits the cytokine interaction with the Il-17 receptors, inhibiting the inflammatory cascade. Read More

    Hidradenitis suppurativa is characterised by dysregulation of the Th17:Treg cell axis, which is corrected by anti-TNF therapy.
    J Invest Dermatol 2017 Jun 23. Epub 2017 Jun 23.
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. Electronic address:
    Hidradenitis suppurativa (HS) is a chronic, inflammatory and debilitating disease of hair follicles with 1-4% prevalence and high morbidity. There is a dearth of information on the pathogenesis and immune dysregulation underlying HS therefore we carried out a detailed analysis of skin infiltrating T cells. Cells isolated from skin biopsies and blood from HS patients and healthy controls were analysed by 16-parameter flow cytometry to provide detailed profiles of CD4 T cell subsets. Read More

    Sonographic Comparison of Morphologic Characteristics Between Pilonidal Cysts and Hidradenitis Suppurativa.
    J Ultrasound Med 2017 Jun 26. Epub 2017 Jun 26.
    Departments of Dermatology, Hospital Clinico, Faculty of Medicine, University of Chile, Santiago, Chile.
    Objectives: To compare the sonographic characteristics of pilonidal cysts and hidradenitis suppurativa.

    Methods: A retrospective study of sonographic examinations was performed on 2 groups: 1 with pilonidal cysts and the other with hidradenitis suppurativa. The sonographic characteristics of the pilonidal cyst and hidradenitis suppurativa groups were analyzed, compared, and correlated, including an analysis of the histologic findings. Read More

    A New Perspective on Isotretinoin Treatment of Hidradenitis Suppurativa: A Retrospective Chart Review of Patient Outcomes.
    Dermatology 2017 Jun 23. Epub 2017 Jun 23.
    School of Medicine, Queen's University, Kingston, ON, Canada.
    Background: Hidradenitis suppurativa (HS) is a disease characterized by the development of painful, deep-seeded nodules and abscesses. Treatment guidelines include a combination of lifestyle, surgical, and medical interventions. Isotretinoin has not been included in the treatment guidelines due to the limited number of studies and conflicting reports of efficacy. Read More

    Approach to the Management of Patients With Hidradenitis Suppurativa: A Consensus Document.
    J Cutan Med Surg 2017 Jun 1:1203475417716117. Epub 2017 Jun 1.
    9 Centre de Recherche Dermatologique du Québec Metropolitain, Quebec, QC, Canada.
    Background: Hidradenitis suppurativa (HS) is a painful, debilitating, and poorly understood condition, which is suboptimally diagnosed, managed, and treated. Evidence supporting various treatment modalities is sparse.

    Objectives: To incorporate scientific evidence and expert opinions to develop useful guidance for the evaluation and management of patients with HS. Read More

    Development and validation of IHS4, a novel dynamic scoring system to assess hidradenitis suppurativa/acne inversa severity.
    Br J Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité University Medicine, Berlin, Germany.
    Background: A validated tool for the dynamic severity assessment of hidradenitis suppurativa (HS) is lacking. The aim of this study was to develop and validate such a novel scoring system.

    Methods: A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Read More

    Hidradenitis Suppurativa in Down Syndrome: A Case Series.
    Pediatr Dermatol 2017 Jul 21;34(4):461-464. Epub 2017 Jun 21.
    King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
    Background/objectives: Many dermatologic and systemic diseases have been reported in association with hidradenitis suppurativa, but its association with Down syndrome is rarely mentioned in the literature. The objective of the current study was to assess the frequency of hidradenitis suppurativa in patients with Down syndrome who visited our clinic over 4 years.

    Methods: We recorded the presenting complaints and dermatologic problems of patients with Down syndrome who visited our clinic from January 2011 to December 2014. Read More

    The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.
    Arch Dermatol Res 2017 Jun 20. Epub 2017 Jun 20.
    Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.
    Recently, we could show that the expression levels of the key regulators of the microRNA (miRNA) maturation and transport were dysregulated in inflamed hidradenitis suppurativa (HS) tissue (Heyam et al. in Wiley Interdiscip Rev RNA 6:271-289, 2015). The RNA-induced silencing complex (RISC) is the central element of the miRNA pathway and regulates miRNA formation and function. Read More

    Examining the race-specific prevalence of hidradenitis suppurativa at a large academic center; results from a retrospective chart review.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Department of Dermatology, University of Cincinnati, Cincinnati, Ohio.
    Hidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating disease of unknown etiology. HS can occur in people of all ethnicities and ages, and affects approximately 3-4% of the United States. To date, few studies have specifically examined the race prevalence of HS; further epidemiological research is needed to identify specific trends among HS and its racial predilections. Read More

    PASH syndrome a disease with genetic heterogeneity.
    Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.
    Department of Dermatology and Venereology, University Hospital of Brest.
    PASH syndrome is a clinical entity associating pyoderma gangrenosum (PG), severe acne and hidradenitis suppurativa (HS)(1) . Absence of pyogenic sterile arthritis (PA) distinguishes PASH syndrome from PAPASH and PAPA syndromes which associate PA in combination with PG, severe acne with or without HS, respectively(2,3) . Mutations in PSTPIP1 (proline-serine-threonine-phosphatase interacting protein 1) gene were identified in patients with PAPA and PAPASH syndromes, although genetic heterogeneity was observed in PAPA syndrome(2,3) . Read More

    Oral ofloxacin and clindamycin as an alternative to the classic rifampicin/clindamycin in hidradenitis suppurativa: retrospective analysis of 65 patients.
    Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.
    Department of Dermatology, Edouard Herriot Hospital, Claude Bernard Lyon I University, Lyon, France.
    Rifampicin/Clindamycin (RC) combination is recommended as first line therapy in moderate to severe Hidradenitis Suppurativa (HS) by European S1 guidelines (1-3), notably because a large variety of microorganisms have been isolated from HS lesions: most represented bacteria appear to be Staphylococcus aureus, Coagulase negative staphylococci (CoNS) and anaerobic bacteria from normal skin flora. It has been hypothesized that these bacteria could play a central role in the initiation and maybe in the maintenance of HS lesions, possibly by being a source of antigens in a dysregulated immune response. This article is protected by copyright. Read More

    35-Year Experience with Surgical Treatment of Hidradenitis Suppurativa.
    World J Surg 2017 Jun 13. Epub 2017 Jun 13.
    University of Michigan, TC 2124 University Hospital SPC 5343, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
    Background: Hidradenitis suppurativa is a painful and disfiguring chronic inflammatory condition affecting both men and women. Medical treatments, such as antibiotics and immunosuppressive agents, are often ineffective. Over time, patients can suffer from recurrent abscesses, chronic purulent drainage, scarring, and contractures that can only be corrected by surgical excision. Read More

    Botulinum Toxin Off-Label Use in Dermatology: A Review.
    Skin Appendage Disord 2017 Mar 1;3(1):39-56. Epub 2017 Feb 1.
    Dermatology Unit, Department of Clinical and Molecular Sciences, United Hospital of Ancona, Polytechnic Marche University, Ancona, Italy.
    Background: Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It is currently used for aesthetic treatments and in the focal hyperhidrosis. Recently, botulinum toxin has also been used experimentally in many other dermatological conditions with good results. Read More

    The Burden of Hidradenitis Suppurativa in a Cohort of Patients in Southern Finland: A Pilot Study.
    Skin Appendage Disord 2017 Mar 12;3(1):20-27. Epub 2017 Jan 12.
    Department of Dermatology and Allergology, AbbVie Oy, Espoo, Finland.
    Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that impacts the quality of life.

    Methods: We evaluated its burden in a cohort of 26 Finnish patients in a single-center cross-sectional study. Demographic data, disease history, clinical data, treatment patterns, and workability were collected. Read More

    Optimal wound care management in hidradenitis suppurativa.
    J Dermatolog Treat 2017 Jun 29:1-3. Epub 2017 Jun 29.
    a Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
    Introduction: Hidradenitis suppurativa (HS) presents the problem of a chronic, relapsing, painful, draining wound. There is a myriad of HS wound care management strategies implemented by clinicians and patients centered around which dressings to use. Many factors affect which HS wound care dressing is the most appropriate to use such as the type of HS wound, cost, ease of application, patient comfort, absorbency and odor management among many others. Read More

    Development and initial psychometric evaluation of patient-reported outcome questionnaires to evaluate the symptoms and impact of hidradenitis suppurativa.
    J Dermatolog Treat 2017 Jul 4:1-13. Epub 2017 Jul 4.
    c Adelphi Values USA , Boston , MA , USA.
    Background: Two patient-reported outcome (PRO) questionnaires, the Hidradenitis Suppurativa Symptom Assessment (HSSA) and Hidradenitis Suppurativa Impact Assessment (HSIA), were developed to measure signs, symptoms and impacts of HS in treatment efficacy studies.

    Methods: In accordance with FDA guidelines and published best practices, four stages of research were conducted to create the questionnaires: concept elicitation, questionnaire construction, content evaluation and psychometric evaluation.

    Results: Subjects (N = 20) who participated in the concept elicitation stage reported 15 unique HS-related signs and symptoms and 51 impacts. Read More

    Increased expression of the interleukin-36 cytokines in lesions of hidradenitis suppurativa.
    J Eur Acad Dermatol Venereol 2017 Jun 11. Epub 2017 Jun 11.
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
    Background: Hidradenitis suppurativa (HS) is a recalcitrant chronic skin disease with poorly understood immunopathogenic mechanisms. Previous studies reported that the interleukin-36 (IL-36) cytokines (IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist [IL-36RA]) are important players in the pathogenesis of psoriasis (PS).

    Objective: We aim to determine whether the IL-36 cytokines are upregulated in HS patients. Read More

    Comment on: "Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study".
    Am J Clin Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Dermatology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), C/ Maestro Alonso s/n, 03010, Alicante, Spain.

    Analysis of risk factors associated with unplanned reoperations following pediatric plastic surgery.
    J Plast Reconstr Aesthet Surg 2017 May 18. Epub 2017 May 18.
    Baylor College of Medicine, Houston, TX, USA. Electronic address:
    Background/purpose: Unplanned reoperation (UR) is an outcome measure with multiple advantages that can be used as a standardized tool to assess an institution's quality and safety of medical care. This study aimed to identify parameters associated with an increased likelihood of UR following plastic surgery in patients less than 18 years of age by using a large validated national multicenter database.

    Methods/description: We performed a retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) Pediatric database between 2012 and 2014 to identify pediatric patients undergoing primary plastic surgery procedures. Read More

    Thyroid autoimmunity in patients with hidradenitis suppurativa: a case-control study.
    Clin Exp Dermatol 2017 Aug 7;42(6):642-644. Epub 2017 Jun 7.
    Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Cantabria, Spain.
    The aetiopathogenesis of hidradenitis suppurativa (HS) is not fully understood; however, increasing evidence suggests that it may be an immune-mediated disorder. Autoimmune thyroid disease (AITD) has classically been considered as the 'paradigm' of autoimmunity, and it has been linked to a variety of skin disorders. To our knowledge, the prevalence of AITD has not been investigated in patients with HS. Read More

    Axillary Reconstruction for Hidradenitis Suppurativa with an Inner-Arm Transposition Flap Creating a Brachioplasty Effect.
    Arch Plast Surg 2017 May 22;44(3):228-233. Epub 2017 May 22.
    Department of Plastic and Reconstructive Surgery, St George's Healthcare NHS Trust, London, UK.
    Background: Hidradenitis suppurativa (HS) is a chronic skin condition that can affect any area with apocrine sweat glands and has the potential to involve multiple sites concurrently. Commonly affected sites include the axilla, groin, perineum and perianal areas. In this study we performed a literature review on the surgical methods for HS and describe an innovative technique for reconstructing axilla HS using an inner-arm transposition flap. Read More

    Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review.
    Skin Appendage Disord 2017 May 21;3(2):95-110. Epub 2017 Mar 21.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with painful nodules, abscesses, sinus tracts, and scarring primarily affecting apocrine gland-rich intertriginous areas. HS prevalence ranges from 0.05 to 1%. Read More

    Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa.
    J Am Acad Dermatol 2017 Aug 24;77(2):268-273.e6. Epub 2017 May 24.
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address:
    Background: Hidradenitis suppurativa (HS) is a debilitating skin disease characterized by painful recurrent nodules and abscesses caused by chronic inflammation. Early events in the development of HS are believed to occur in the folliculopilosebaceous unit; however, the signaling pathways behind this mechanism are unknown. Sphingolipids, such as ceramide, are essential components of the skin and appendages and have important structural and signaling roles. Read More

    The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls.
    JAMA Dermatol 2017 May 24. Epub 2017 May 24.
    Department of Dermatology, Zealand University Hospital, Health Sciences Faculty, University of Copenhagen, Roskilde, Denmark.
    Importance: Although the pathogenesis of hidradenitis suppurativa (HS) remains enigmatic, several factors point to potential involvement of the cutaneous microbiome. Insight into the cutaneous microbiome in HS using next-generation sequencing may provide novel data on the microbiological diversity of the skin.

    Objective: To investigate the follicular skin microbiome in patients with HS and in healthy controls. Read More

    Hidradenitis suppurativa: epidemiological study of cases diagnosed at a dermatological reference center in the city of Bauru, in the Brazilian southeast State of São Paulo, between 2005 and 2015.
    An Bras Dermatol 2017 Mar-Apr;92(2):196-199
    Department of Dermatology, Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
    Background:: Hidradenitis is a chronic inflammatory disease of the hair follicles. A treatment is necessary due to chronicity and psychological changes that patient present.

    Objective:: To investigate epidemiological aspects and elaborate a risk group profile, promote early diagnosis and contribute to the knowledge about the disease. Read More

    Major gaps in understanding and treatment of hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):86-92
    Laboratory for Investigative Dermatology, Rockefeller University, New York, New York, USA.
    Hidradenitis suppurativa (HS) is a complex dermatological disease characterized by recurrent painful nodules and suppuration in areas such as the axilla and groin. The disease is poorly understood and treatment is not satisfactory. In October 2016, the Canadian and United States Hidradenitis Suppurativa Foundations organized the inaugural Symposium on Hidradenitis Suppurativa Advances (SHSA) in Toronto, Canada. Read More

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