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    1860 results match your criteria Neutrophilic Eccrine Hidradenitis

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    Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study.
    Am J Clin Dermatol 2017 Apr 20. Epub 2017 Apr 20.
    Department of Dermatology, Erasmus University Medical Center, Burgemeester s' Jacobplein 51, 3015 CA, Rotterdam, The Netherlands.
    Background: Pruritus is still a forgotten aspect of hidradenitis suppurativa (HS) and, to date, has never been adequately studied.

    Objective: The aim of this study was to determine the prevalence, and explore the characteristics, of pruritus in a well-defined cohort of HS patients.

    Setting: An academic hospital-based cross-sectional study in The Netherlands. Read More

    Hidradenitis Suppurativa Complicating Epithelial Malignancy in Immunocompromised Patient.
    J Assoc Physicians India 2016 Dec;64(12):90-92
    Associate Professor in Medicine.
    Hidradenitis suppurativa complicating epithelial malignancy in people living with HIV is very rare. Hidradenitis suppurativa is very rare seen in only 1% of general population and 4% of young adults. We report a case of Hidradenitis suppurativa complicating an epithelial malignancy in are immunocompromised (HIV reactive) patient. Read More

    Rare "Inverted" Verrucous Carcinoma (Carcinoma Cuniculatum) of the Sacrogluteal Region.
    Int J Surg Pathol 2017 Feb 1:1066896917696753. Epub 2017 Feb 1.
    1 Royal Hobart Hospital, Hobart, Tasmania, Australia.
    A 49-year-old woman with a past history of several infundibular cysts in the head and neck region presented with a 6-month history of a nonhealing perianal abscess on a background of 13 years of chronic sacral-buttock abscesses and discharging sinuses as part of hidradenitis suppurativa. After 2 surgical procedures and inadequate healing, a wide local excision was performed. The surgical specimen revealed an extensive, infiltrating, cystic and deeply penetrating, dermal and subcutaneous neoplasm with multiple fistulous tracts extending to the skin surface. Read More

    The microbiological landscape of anaerobic infections in Hidradenitis Suppurativa: a prospective metagenomic study.
    Clin Infect Dis 2017 Apr 1. Epub 2017 Apr 1.
    Paris Descartes University, Sorbonne Paris Cité, 12 Rue de l'École de Médecine, 75006, Paris, France.
    Background.: Hidradenitis suppurativa (HS) is a frequent and severe disease of the skin, characterized by recurrent or chronic skinfolds suppurative lesions with a high impact on quality of life. Although considered inflammatory, antimicrobial treatments can improve or lead to clinical remission of HS, suggesting triggering microbial factors. Read More

    The role of wide local excision for the treatment of severe hidradenitis suppurativa (Hurley grade III): Retrospective analysis of 74 patients.
    J Am Acad Dermatol 2017 Apr 1. Epub 2017 Apr 1.
    Department of Dermatology and Venerology, Rudolfstiftung Hospital, Vienna, Austria; School of Medicine, Sigmund Freud University, Vienna, Austria.
    Background: Effective medical treatment for patients with severe hidradenitis suppurativa (HS) is limited.

    Objectives: We sought to measure the impact of wide local excision on quality of life in HS Hurley grade III patients and to examine the rate of postoperative complications, disease recurrences, and satisfaction with the cosmetic results.

    Methods: Seventy-four patients were enrolled. Read More

    Medical Infrared Thermography assistance in the surgical treatment of axillary Hidradenitis Suppurativa: A case report.
    Int J Surg Case Rep 2017 16;34:56-59. Epub 2017 Mar 16.
    GRESPI, EA 4694, Research Group in Engineering Sciences, University of Reims, Reims, France. Electronic address:
    Background: The purpose of this case report is to highlight for the first time the way Medical Infrared Thermography can be a helpful tool to assist the surgeon in the surgical treatment of Hidradenitis Suppurativa inflammatory disease.

    Methods: A 36-year-old man with a 7-year history of Hidradenitis Suppurativa presented inflammatory nodules in the left axilla area corresponding to Hurley stage II. Choice is made to surgically treat this patient using a wide excision protocol combined with a postoperative second intention healing. Read More

    Interventions for Hidradenitis Suppurativa: Updated Summary of an Original Cochrane Review.
    JAMA Dermatol 2017 Mar 29. Epub 2017 Mar 29.
    Department of Dermatology & Academic Wound Healing, Institute of Infection & Immunity, Cardiff University, Wales.
    Clinical Question: Which treatments have been shown to be effective in randomized clinical trials (RCTs) for hidradenitis suppurativa (HS) in adults?

    Bottom Line: There is high-quality evidence of benefit from adalimumab given weekly, while every other week dosing is ineffective, with reductions in Dermatology Life Quality Index (DLQI) scores compared with placebo of 2.8 points (95% CI, -3.7 to -2. Read More

    Hidradenitis suppurativa in Crohn's disease during adalimumab therapy: a paradox?
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Mar;26(1):21-23
    Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
    A sporadic association between hidradenitis suppurativa and other diseases is reported in the literature, but few authors have described the association with Crohn's disease. Adalimumab is a fully human monoclonal antibody targeted at tumor necrosis factor alpha approved for the treatment of Crohn's disease and, recently, for active moderate to severe hidradenitis suppurativa in adult patients that do not respond adequately to systemic conventional treatment. We report an unusual case of a paradoxical effect of adalimumab in the onset of hidradenitis suppurativa in a 40-year-old woman during the treatment of Crohn's disease. Read More

    Autoinflammatory syndromes associated with hidradenitis suppurativa and/or acne.
    Int J Dermatol 2017 Mar 27. Epub 2017 Mar 27.
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
    Autoinflammatory syndromes associated with hidradenitis suppurativa (HS) and/or acne are rare but potentially debilitating disorders if not diagnosed and treated correctly. They share a common pathogenesis involving a dysregulated innate immune system with abnormal interleukin (IL)-1 signaling leading to sterile neutrophilic inflammation. The clinical features are recurrent episodes of fever, painful arthritis, and skin lesions consistent with HS, acne, and pyoderma gangrenosum (PG) accompanied by elevated systemic inflammatory markers in blood. Read More

    Surgical Management of Hidradenitis Suppurativa: A 14-Year Retrospective Review of 98 Consecutive Patients.
    J Burn Care Res 2017 Mar 15. Epub 2017 Mar 15.
    From the *Department of Surgery, University of Iowa; †Department of Surgery, University of Arkansas and Arkansas Children's Hospital, Little Rock; and ‡Department of Nursing, University of Iowa.
    Hidradenitis suppurativa (HS) is a debilitating suppurative disease of the apocrine/follicular glands. Medical treatment has some efficacy in early-stage disease but is costly and requires frequent physician visits. Advanced disease usually requires surgical intervention. Read More

    Hidradenitis suppurativa gains increasing interest on World Wide Web: a source for patient information?
    Int J Dermatol 2017 Mar 21. Epub 2017 Mar 21.
    Department of Urology, University Hospital Mainz, Mainz, Germany.
    Background: Gathering health information from Internet websites is increasingly utilized by patients. No data exist about hidradenitis suppurativa (HS)-related online health information. Thus, we aimed to study the quality, popularity, readability, and timeliness of the most frequented websites on HS. Read More

    Interleukin-32 is highly expressed in lesions of hidradenitis suppurativa.
    Br J Dermatol 2017 Mar 16. Epub 2017 Mar 16.
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern.
    Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Its immunopathogenic mechanisms are still poorly understood. Previous studies could demonstrate that the pro-inflammatory cytokine Interleukin-32 (IL-32) is implicated in the pathogenesis of other inflammatory diseases. Read More

    Steatocystoma multiplex suppurativa: case report of a rare condition.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):51-53
    Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
    Steatocystoma multiplex is a rare genetic disorder characterized by the presence of hamartomatous malformations at the junction of the pilosebaceous duct. It consists of encapsulated cystic lesions in the dermis, with adjacent sebaceous gland. When associated with inflammation, resembling hidradenitis, it is called steatocystoma multiplex suppurativa, a condition rarely reported. Read More

    The International Dermatology Outcome Measures (IDEOM) Initiative: A Review and Update.
    J Drugs Dermatol 2017 Feb;16(2):119-124

    The International Dermatology Outcome Measures (IDEOM) group, comprising patients, physicians, health economists, industry partners, payers, and regulatory agencies, was established to develop unified and validated patient-centered outcome measures in dermatology in response to increasing demand to quantify effectiveness of treatments and performance outcomes among providers. IDEOM has chosen to start with psoriasis outcome measures, and then apply its methodology to other dermatologic diseases. In this paper, we review the background and progress to date of IDEOM, including an update of IDEOM activities as of our 2016 meeting in Washington DC, USA. Read More


    Generalized Comedones, Acne, and Hidradenitis Suppurativa in a Patient with an FGFR2 Missense Mutation.
    Front Med (Lausanne) 2017 28;4:16. Epub 2017 Feb 28.
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland; King's College, St John's Institute of Dermatology, London, UK.
    Mutations in the fibroblast growth factor-receptor gene 2 (FGFR2) gene have been implicated in numerous diseases, including nevus comedonicus (NC) and naevoid acne that have somatic missense mutations in FGFR2 in the affected tissue. A patient presented in our department with unusual, innumerable large comedones throughout his back reminiscient of NC, as well as multifocal hidradenitis suppurativa and acne. Topical and systemic treatments were unsuccessful. Read More

    Anoperineal disease in Hidradenitis Suppurativa : MR imaging distinction from perianal Crohn's disease.
    Eur Radiol 2017 Mar 13. Epub 2017 Mar 13.
    Department of Radiology, Hôpital Maison Blanche, Avenue du Général Koenig, 51092, Reims Cedex, France.
    Objective: To determine whether Hidradenitis suppurativa (HS)-related anoperineal disease can be distinguished from Crohn's disease (CD) using MRI.

    Methods: Pelvic MRI of 23 HS and 46 CD patients with anoperineal disease between 2007 and 2014 were independently analysed by two radiologists. For diagnosis of HS, sensitivity, specificity and positive likelihood ratios (LRs) of inflammatory features and of their anatomical distribution were calculated and compared to those of CD. Read More

    Incidence of hidradenitis suppurativa in the United States: A sex- and age-adjusted population analysis.
    J Am Acad Dermatol 2017 Mar 9. Epub 2017 Mar 9.
    Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, New York.
    Background: The true incidence of hidradenitis suppurativa (HS) is unknown.

    Objective: To determine standardized incidence estimates for HS in the United States.

    Methods: We used a retrospective cohort analysis, including incident HS cases identified using electronic health records data for a demographically heterogeneous population-based sample of >48 million unique patients across all 4 census regions. Read More

    A Systematic Review and Critical Evaluation of Reported Pathogenic Sequence Variants in Hidradenitis Suppurativa.
    Br J Dermatol 2017 Mar 9. Epub 2017 Mar 9.
    Department of Dermatology, Liverpool Hospital.
    Introduction: Hidradenitis Suppurativa (HS) is a severe chronic inflammatory disorder characterised by recurrent painful deep seated nodules with a predilection to the apocrine bearing areas of skin. A minority of cases of HS are due to mutations in the gamma secretase complex. Contention exists surrounding the pathogenicity of sequence variants and their effects upon notch signalling. Read More

    Squamous cell carcinoma arising in long-standing hidradenitis suppurativa: An overlooked facet of the immunocompromised district.
    Clin Dermatol 2017 Mar - Apr;35(2):225-227. Epub 2016 Oct 27.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
    The list of comorbidities and complications associated with hidradenitis suppurativa is extensive. Among the complications of hidradenitis suppurativa, squamous cell carcinoma is considered the most severe. After a meticulous literature research starting from the 1950s, we were able to identify over 90 cases of patients with hidradenitis suppurativa developing squamous cell carcinoma. Read More

    Treatments for hidradenitis suppurativa.
    Clin Dermatol 2017 Mar - Apr;35(2):218-224. Epub 2016 Oct 27.
    Department of Dermatology, Zealand University Hospital, Roskilde, Denmark; Health Sciences Faculty, University of Copenhagen, Denmark.
    Hidradenitis suppurativa (HS) is not easily treated. Although not uncommon, HS is often misdiagnosed outside specialized clinics and inappropriately treated as a simple boil or abscess. In recent years, guidelines have been developed on the basis of expert opinion and the available literature. Read More

    Difficult and rare forms of acne.
    Clin Dermatol 2017 Mar - Apr;35(2):138-146. Epub 2016 Oct 27.
    Department of Dermatology, Andreas Syggros Hospital, University of Athens, 5, Dragoumi str, 16121, Athens, Greece.
    Acne is the most common of skin diseases, being characterized as a chronic inflammatory disease of the pilosebaceous unit. Although acne is usually straightforward to diagnose and treat, some patients have difficult or rare forms of acne. What seems to be "nonresponding acne" in a patient may be caused by another acneiform disease that clinically mimics acne, thus misleading the clinician, if not ruled out, with scrutiny. Read More

    Increased serum interleukin-6 levels in patients with hidradenitis suppurativa.
    Postepy Dermatol Alergol 2017 Feb 7;34(1):82-84. Epub 2017 Feb 7.
    Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Jiangsu, China; Department of Dermatology, Institute of Plastic Surgery, Chinese Academy of Medical Sciences, Beijing, China.

    Higher Risk of Care for Hidradenitis Suppurativa in African American and Non-Hispanic Patients in the United States.
    J Natl Med Assoc 2017 Spring;109(1):44-48. Epub 2016 Sep 28.
    Department of Surgery, Division of Dermatology, University of Kentucky College of Medicine, USA.
    Hidradenitis suppurativa (HS) is a chronic cutaneous inflammatory disease. Few reports have been published on the influence of race, ethnicity, and other patient demographic factors as determinants of care for HS. Data from the 2005 to 2011 National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey (NHAMCS) were analyzed for to assess factors that were predictive of outpatient visits for HS. Read More

    Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa / hidradenitis suppurativa.
    Br J Dermatol 2017 Mar 3. Epub 2017 Mar 3.
    Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité University Medicine, Berlin, Germany.
    Background: Acne inversa (AI)/Hidradenitis suppurativa is a chronic inflammatory disease characterized by painful axillary, inguinal, and perianal skin lesions with deep-seated nodules, abscesses, and fistulae.

    Objectives: This study aimed at the identification and characterization of key players in AI pathogenesis.

    Methods: Epidemiologic and anamnestic data as well as blood and skin samples of AI patients were collected. Read More

    PAPA, PASH and PAPASH Syndromes: Pathophysiology, Presentation and Treatment.
    Am J Clin Dermatol 2017 Feb 25. Epub 2017 Feb 25.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
    Pyoderma gangrenosum (PG) is a neutrophilic dermatosis usually manifesting as skin ulcers with undermined erythematous-violaceous borders. It may be isolated, associated with systemic conditions or occurring in the context of autoinflammatory syndromes such as PAPA (pyogenic arthritis, PG and acne), PASH (PG, acne and suppurative hidradenitis) or PAPASH (pyogenic arthritis, acne, PG and suppurative hidradenitis). From a physiopathological point of view, all these conditions share common mechanisms consisting of over-activation of the innate immune system leading to increased production of the interleukin (IL)-1 family and 'sterile' neutrophil-rich cutaneous inflammation. Read More

    Photodynamic Therapy and Skin Appendage Disorders: A Review.
    Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

    Protocol for the development of a core domain set for hidradenitis suppurativa trial outcomes.
    BMJ Open 2017 Feb 20;7(2):e014733. Epub 2017 Feb 20.
    Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
    Introduction: Randomised controlled trials (RCTs) should have well-defined primary and secondary outcomes to answer questions generated by the main hypotheses. However, for the chronic, inflammatory skin disease hidradenitis suppurativa (HS), the reported outcome measures are numerous and diverse. A recent systematic review found a total of 30 outcome measure instruments in 12 RCTs. Read More

    What is hidradenitis suppurativa?
    Can Fam Physician 2017 Feb;63(2):114-120
    Lecturer in the Division of Dermatology at the University of Toronto.
    Objective: To provide family physicians with an understanding of the epidemiology, clinical features, diagnosis, and management of hidradenitis suppurativa (HS).

    Sources Of Information: A PubMed literature search was performed using the MeSH term hidradenitis suppurativa.

    Main Message: Hidradenitis suppurativa is a chronic, recurrent, and debilitating skin condition. Read More

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