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    1896 results match your criteria Neutrophilic Eccrine Hidradenitis

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    The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls.
    JAMA Dermatol 2017 May 24. Epub 2017 May 24.
    Department of Dermatology, Zealand University Hospital, Health Sciences Faculty, University of Copenhagen, Roskilde, Denmark.
    Importance: Although the pathogenesis of hidradenitis suppurativa (HS) remains enigmatic, several factors point to potential involvement of the cutaneous microbiome. Insight into the cutaneous microbiome in HS using next-generation sequencing may provide novel data on the microbiological diversity of the skin.

    Objective: To investigate the follicular skin microbiome in patients with HS and in healthy controls. Read More

    Hidradenitis suppurativa: epidemiological study of cases diagnosed at a dermatological reference center in the city of Bauru, in the Brazilian southeast State of São Paulo, between 2005 and 2015.
    An Bras Dermatol 2017 Mar-Apr;92(2):196-199
    Department of Dermatology, Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
    Background:: Hidradenitis is a chronic inflammatory disease of the hair follicles. A treatment is necessary due to chronicity and psychological changes that patient present.

    Objective:: To investigate epidemiological aspects and elaborate a risk group profile, promote early diagnosis and contribute to the knowledge about the disease. Read More

    Major gaps in understanding and treatment of hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):86-92
    Laboratory for Investigative Dermatology, Rockefeller University, New York, New York, USA.
    Hidradenitis suppurativa (HS) is a complex dermatological disease characterized by recurrent painful nodules and suppuration in areas such as the axilla and groin. The disease is poorly understood and treatment is not satisfactory. In October 2016, the Canadian and United States Hidradenitis Suppurativa Foundations organized the inaugural Symposium on Hidradenitis Suppurativa Advances (SHSA) in Toronto, Canada. Read More

    Complications of hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):79-85
    Department of Dermatology, University of California, San Francisco, USA.
    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent painful nodules and abscesses involving intertriginous areas. Repeated episodes of profound inflammation in HS can lead to a number of complications, causing significant morbidity and decreasing quality of life. Complications of HS may affect the skin alone or may have systemic impact. Read More

    Quality of life considerations and pain management in hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):75-78
    Deptartment of Dermatology, Zealand University Hospital, Roskilde, and Health Sciences Faculty, University of Copenhagen, Denmark.
    All skin diseases involve some element of stigmatization and psychosocial consequence for the individual patient, but few, if any, skin diseases can match the impact of hidradenitis suppurativa (HS) on the patient. The inflamed lesions progressing to noninflamed nodules and abscesses are not only perceived as unclean and stigmatizing by the patients, but also cause pain and scarring making this inflammatory skin disorder unique. It is obvious that the disease has a significant negative impact on the patients' quality of life (QOL). Read More

    A retrospective review of light- and laser-based management of hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):67-74
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.
    Hidradenitis suppurativa (HS) is a chronic skin disease that is difficult to manage and often refractory to medical management. Light and laser therapies have been utilized in the field of dermatology to treat a variety of skin conditions, but more recently were studied in the management of HS. Usually performed as outpatient procedures with a low risk of complications, they offer several advantages to traditional cold knife surgical procedures. Read More

    Medical management of hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):62-66
    Departments of Dermatology and Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.
    Hidradenitis suppurativa is a chronic inflammatory disease of the folliculo-infundibular unit for which no individual treatment is uniformly effective. A wide array of therapies has been reported successful in the treatment of hidradenitis, although few high-quality clinical trials have been conducted. Comparing the effectiveness of different therapies has proven challenging due to heterogeneity and limited validation of outcome measures. Read More

    Topical management and wound care approaches for hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):58-61
    Department of Dermatology, University of Cincinnati, Ohio, USA.
    Hidradenitis suppurativa (HS) is a chronic inflammatory disease that affects the follicular unit in apocrine glandbearing skin, resulting in deep-seated nodules, sinus tracts, abscesses, and ultimately scarring. HS is a highly distressing condition, and has one of the highest impacts on quality of life compared to other dermatologic diseases. Various topical therapies have been described that may be used alone or in conjunction with systemic or physical modalities for HS. Read More

    Comorbidities of hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):55-57
    Department of Dermatology, Harvard Medical School and Harvard Medical Faculty Physicians, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
    Hidradenitis suppurativa (HS) is an inflammatory skin disorder with many associated comorbidities, including obesity, metabolic syndrome, smoking, depression, arthritis, autoinflammatory syndromes, inflammatory bowel disease, and genetic syndromes. In addition, HS patients can suffer from a variety of diseases related to the chronic inflammatory nature of their HS such as cardiovascular disease and anemia. An understanding of these comorbidities and associations is essential for the management of HS, and routine screening for these entities should be considered in all HS patients. Read More

    Pathophysiology of hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):47-54
    Laboratory for Investigative Dermatology, Rockefeller University, New York, New York, USA.
    The pathophysiology of hidradenitis suppurativa (HS) is not well understood. Some of our knowledge comes from clinical and epidemiological observations, along with studies of the histopathology and immunohistochemistry of affected skin. More recently, cutaneous molecular studies and transcriptomic analyses have provided additional information regarding inflammatory processes. Read More

    Epidemiologic and clinical features of hidradenitis suppurativa.
    Semin Cutan Med Surg 2017 Jun;36(2):42-46
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
    Hidradenitis suppurativa (HS) is an inflammatory condition characterized by recurrent abscesses which may result in sinus tracts and dermal scarring. This article reviews current epidemiologic data on HS in diverse populations, including prevalence based on geography, age, gender, ethnicity, and details the spectrum of clinical features of hidradenitis suppurativa with discussion of disease severity and risk factors. Recently proposed HS diagnostic criteria are also presented. Read More

    Hidradenitis suppurativa, introduction.
    Semin Cutan Med Surg 2017 Jun;36(2):41
    Department of Dermatology, University of California, San Francisco, California, USA.
    Hidradenitis suppurativa (HS) is a prevalent and devastating inflammatory skin disease predominating in women and minorities. HS is characterized by painful recurrent abscesses, foul-smelling purulent drainage, sinus tract and fistula formation, and disfiguring scarring involving intertriginous body sites including the axillae, breasts, groin, and buttocks. Disease onset typically occurs in the second to fourth decades of life and is associated with significant impacts on physical and psychological well-being due to pain, shame, and isolation, leading to profound suffering and despair. Read More

    Ultrasound Evaluation as a Complementary Test in Hidradenitis Suppurativa: Proposal of a Standarized Report.
    Dermatol Surg 2017 May 22. Epub 2017 May 22.
    *Department of Dermatology, Hospital de Manises, Valencia, Spain;†Departments of Radiology and Dermatology, Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Clinica Servet, Faculty of Medicine, University of Chile, Santiago, Chile;‡Department of Dermatology, Hospital Puerta del Hierro, Majahonda, Madrid, Spain;§Department of Dermatology, Virgen de las Nieves University Hospital, Granada, Spain;‖Department of Radiology, National Cancer Institute Fondazione Pascale, Naples, Italy;¶Department of Radiology, Università degli studi di Napoli, Naples, Italy;#Department of Dermatology, Roskilde Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark;**Department of Radiology, Affiliation Hospital das Clínicas da Faculdade de Medicina de São Paulo, Brazil;††Department of Medical Imaging, Rambam Health Care Centre, Haifa, Israel;‡‡Department of Radiology, IDIME Instituto de Imágenes Diagnósticas, Bogota, Colombia;§§Bard Cancer Center, New York, New York;‖‖Department of Dermatology, Clínica Universidad de Navarra, Madrid, Spain;¶¶Department of Radiodiagnosis, Central Hospital, South Central Railway, Telangana, India.
    Background: Staging and monitoring of patients with hidradenitis suppurativa (HS) have been traditionally based on clinical findings. However, the physical examination may show important limitations because of its poor sensitivity for differentiating between different lesion subtypes, and its low sensitivity to define the disease's activity.

    Objective: To develop a consensus ultrasound (US) report that could summarize the relevant anatomical characteristics and staging of patients considering the experience of radiologists and dermatologists working on imaging of HS. Read More

    Association Between Inflammatory Skin Disease and Cardiovascular and Cerebrovascular Co-Morbidities in US Adults: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Psoriasis, atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis are chronic inflammatory skin disorders associated with systemic immune activation, considerable symptom burden, stigma, functional disturbances, and mental health symptoms. All of these might increase cardiovascular risk.

    Objective: The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease. Read More

    Should Hidradenitis Suppurativa Be Included in Dermatoses Showing Koebnerization? Is It Friction or Fiction?
    Dermatology 2017 May 16. Epub 2017 May 16.
    Background: The etiology of hidradenitis suppurativa (HS) involves genetic and environmental factors. Well-established associated systemic factors are obesity, smoking, inflammation, and bacteria. Whether localized environmental factors such as friction and pressure may also play a causative role is still unclear. Read More

    A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine.
    Nutrients 2017 May 15;9(5). Epub 2017 May 15.
    Department of Rheumatology, Odense University Hospital, 5000 Odense, Denmark.
    Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Read More

    Hidradenitis Suppurativa Is Associated with Familial Mediterranean Fever -A Population-Based Study.
    J Invest Dermatol 2017 May 9. Epub 2017 May 9.
    Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel; Siaal Research Center for Family Medicine and Primary Care, Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

    Sex- and Age-Adjusted Population Analysis of Prevalence Estimates for Hidradenitis Suppurativa in the United States.
    JAMA Dermatol 2017 May 10. Epub 2017 May 10.
    Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, New York.
    Importance: The true prevalence of hidradenitis suppurativa (HS) is unknown.

    Objective: To establish standardized overall and group-specific prevalence estimates for HS in the United States.

    Design, Setting, And Participants: This retrospective analysis included a demographically heterogeneous population-based sample of more than 48 million unique patients across all US census regions. Read More

    Hidradenitis Suppurativa, Intimate Partner Violence, and Sexual Assault.
    J Cutan Med Surg 2017 May 1:1203475417708167. Epub 2017 May 1.
    1 Department of Psychology, University of Windsor, Windsor, Ontario, Canada.
    Background: Sexual assault and intimate partner violence have never been examined in individuals with hidradenitis suppurativa. The research is important, because prior studies show higher incidences of intimate partner violence and sexual assault in individuals with disabilities, and hidradenitis suppurativa meets criteria for a disability.

    Objectives: The objective of the study is to examine whether individuals with hidradenitis suppurativa are at significantly higher risk of intimate partner violence and sexual assault compared with individuals who have acne, a recognised disability. Read More

    Biologics in patients with skin diseases.
    J Allergy Clin Immunol 2017 May;139(5):1423-1430
    Sunnybrook Health Sciences Centre and University of Toronto, Department of Medicine, Division of Dermatology, Toronto, Ontario, Canada. Electronic address:
    Biologic agents are important therapeutic options for treating multiple moderate-to-severe cutaneous diseases. Monoclonal antibodies already in use or under investigation are targeted for psoriasis, atopic dermatitis, melanoma, hidradenitis suppurativa, and pemphigus vulgaris. Read More

    [Diagnosis and treatment of hidradenitis suppurativa].
    Ugeskr Laeger 2017 May;179(18)
    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. Although patients with HS present a distinct symptomatology with a subsequent impairment of quality of life, an overall diagnostic time of seven years has been reported. A better and broader understanding of this disease may potentially reduce the diagnostic delay. Read More

    Sonography of Dermatologic Emergencies.
    J Ultrasound Med 2017 May 4. Epub 2017 May 4.
    Departments of Imaging and Dermatology, Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Faculty of Medicine, University of Chile, Santiago, Chile.
    Dermatologic conditions may be the subjects of potential emergency consultations, and the knowledge of their sonographic appearance can facilitate an early diagnosis and management. In this pictorial essay, the sonographic dermatologic anatomy, technique, and conditions that can be supported by a prompt sonographic diagnosis are reviewed. The sonographic signs that may help diagnose these entities are discussed with a practical approach. Read More

    Hidradenitis suppurativa: from pathogenesis to diagnosis and treatment.
    Clin Cosmet Investig Dermatol 2017 19;10:105-115. Epub 2017 Apr 19.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presenting with painful nodules, abscesses, sinus tracts, and scarring. HS is a multifactorial disease in which genetic and environmental factors play a key role. The primary defect in HS pathophysiology involves follicular occlusion of the folliculopilosebaceous unit, followed by follicular rupture, and immune responses (perifollicular lympho-histiocytic inflammation), finally leading to the development of clinical HS lesions. Read More

    Non-surgical treatments for hidradenitis suppurativa: A systematic review.
    Ann Chir Plast Esthet 2017 Apr 27. Epub 2017 Apr 27.
    Department of plastic, reconstructive and aesthetic surgery, Rangueil hospital, 1, avenue Jean-Poulhès, 31059 Toulouse, France. Electronic address:
    Introduction: The management of hidradenitis suppurativa is multidisciplinary, involving general measures, medical treatment and surgery. Non-surgical treatments, often first-line procedures, mainly concern forms of low-to-moderate severity or, conversely, very severe forms in non-operable patients or those refusing surgery. While many treatments have been attempted, few randomized controlled trials have been conducted, so the choice of treatments is most often based on the personal experience of the clinicians. Read More

    Validation of a Case-Finding Algorithm for Hidradenitis Suppurativa Using Administrative Coding from a Clinical Database.
    Dermatology 2017 Apr 28. Epub 2017 Apr 28.
    Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, NY, USA.
    Background: Requisite to the application of clinical databases for observational research in hidradenitis suppurativa (HS) is the identification of an accurate case cohort.

    Objective: To assess the validity of utilizing administrative codes to establish the HS cohort from a large clinical database.

    Methods: In this retrospective study using chart review as the reference standard, we calculated several estimates of the diagnostic accuracy of at least 1 ICD-9 code for HS. Read More

    Paradoxical psoriasiform reactions to anti-TNFα drugs in hidradenitis suppurativa.
    Br J Dermatol 2017 Apr 26. Epub 2017 Apr 26.
    Dermatology Department, University Hospital of Bordeaux, Bordeaux, France.
    Paradoxical psoriasiform reactions to anti-tumor necrosis factor α (TNFα) agents occur with an incidence of 0.3 to 5.6% in patients with inflammatory bowel diseases and rheumatic diseases(1) . Read More

    Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study.
    Am J Clin Dermatol 2017 Apr 20. Epub 2017 Apr 20.
    Department of Dermatology, Erasmus University Medical Center, Burgemeester s' Jacobplein 51, 3015 CA, Rotterdam, The Netherlands.
    Background: Pruritus is still a forgotten aspect of hidradenitis suppurativa (HS) and, to date, has never been adequately studied.

    Objective: The aim of this study was to determine the prevalence, and explore the characteristics, of pruritus in a well-defined cohort of HS patients.

    Setting: An academic hospital-based cross-sectional study in The Netherlands. Read More

    Hidradenitis Suppurativa Complicating Epithelial Malignancy in Immunocompromised Patient.
    J Assoc Physicians India 2016 Dec;64(12):90-92
    Associate Professor in Medicine.
    Hidradenitis suppurativa complicating epithelial malignancy in people living with HIV is very rare. Hidradenitis suppurativa is very rare seen in only 1% of general population and 4% of young adults. We report a case of Hidradenitis suppurativa complicating an epithelial malignancy in are immunocompromised (HIV reactive) patient. Read More

    Rare "Inverted" Verrucous Carcinoma (Carcinoma Cuniculatum) of the Sacrogluteal Region.
    Int J Surg Pathol 2017 Feb 1:1066896917696753. Epub 2017 Feb 1.
    1 Royal Hobart Hospital, Hobart, Tasmania, Australia.
    A 49-year-old woman with a past history of several infundibular cysts in the head and neck region presented with a 6-month history of a nonhealing perianal abscess on a background of 13 years of chronic sacral-buttock abscesses and discharging sinuses as part of hidradenitis suppurativa. After 2 surgical procedures and inadequate healing, a wide local excision was performed. The surgical specimen revealed an extensive, infiltrating, cystic and deeply penetrating, dermal and subcutaneous neoplasm with multiple fistulous tracts extending to the skin surface. Read More

    The microbiological landscape of anaerobic infections in Hidradenitis Suppurativa: a prospective metagenomic study.
    Clin Infect Dis 2017 Apr 1. Epub 2017 Apr 1.
    Paris Descartes University, Sorbonne Paris Cité, 12 Rue de l'École de Médecine, 75006, Paris, France.
    Background.: Hidradenitis suppurativa (HS) is a frequent and severe disease of the skin, characterized by recurrent or chronic skinfolds suppurative lesions with a high impact on quality of life. Although considered inflammatory, antimicrobial treatments can improve or lead to clinical remission of HS, suggesting triggering microbial factors. Read More

    The role of wide local excision for the treatment of severe hidradenitis suppurativa (Hurley grade III): Retrospective analysis of 74 patients.
    J Am Acad Dermatol 2017 Apr 1. Epub 2017 Apr 1.
    Department of Dermatology and Venerology, Rudolfstiftung Hospital, Vienna, Austria; School of Medicine, Sigmund Freud University, Vienna, Austria.
    Background: Effective medical treatment for patients with severe hidradenitis suppurativa (HS) is limited.

    Objectives: We sought to measure the impact of wide local excision on quality of life in HS Hurley grade III patients and to examine the rate of postoperative complications, disease recurrences, and satisfaction with the cosmetic results.

    Methods: Seventy-four patients were enrolled. Read More

    Medical Infrared Thermography assistance in the surgical treatment of axillary Hidradenitis Suppurativa: A case report.
    Int J Surg Case Rep 2017 16;34:56-59. Epub 2017 Mar 16.
    GRESPI, EA 4694, Research Group in Engineering Sciences, University of Reims, Reims, France. Electronic address:
    Background: The purpose of this case report is to highlight for the first time the way Medical Infrared Thermography can be a helpful tool to assist the surgeon in the surgical treatment of Hidradenitis Suppurativa inflammatory disease.

    Methods: A 36-year-old man with a 7-year history of Hidradenitis Suppurativa presented inflammatory nodules in the left axilla area corresponding to Hurley stage II. Choice is made to surgically treat this patient using a wide excision protocol combined with a postoperative second intention healing. Read More

    Interventions for Hidradenitis Suppurativa: Updated Summary of an Original Cochrane Review.
    JAMA Dermatol 2017 May;153(5):458-459
    Department of Dermatology & Academic Wound Healing, Institute of Infection & Immunity, Cardiff University, Wales.
    Clinical Question: Which treatments have been shown to be effective in randomized clinical trials (RCTs) for hidradenitis suppurativa (HS) in adults?

    Bottom Line: There is high-quality evidence of benefit from adalimumab given weekly, while every other week dosing is ineffective, with reductions in Dermatology Life Quality Index (DLQI) scores compared with placebo of 2.8 points (95% CI, -3.7 to -2. Read More

    Hidradenitis suppurativa in Crohn's disease during adalimumab therapy: a paradox?
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Mar;26(1):21-23
    Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
    A sporadic association between hidradenitis suppurativa and other diseases is reported in the literature, but few authors have described the association with Crohn's disease. Adalimumab is a fully human monoclonal antibody targeted at tumor necrosis factor alpha approved for the treatment of Crohn's disease and, recently, for active moderate to severe hidradenitis suppurativa in adult patients that do not respond adequately to systemic conventional treatment. We report an unusual case of a paradoxical effect of adalimumab in the onset of hidradenitis suppurativa in a 40-year-old woman during the treatment of Crohn's disease. Read More

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