3,511 results match your criteria Neutrophilia


Circulating innate immune markers and outcomes in treatment-naïve advanced non-small cell lung cancer patients.

Eur J Cancer 2019 Jan 12;108:88-96. Epub 2019 Jan 12.

Gustave Roussy Cancer Campus, F-94805, Villejuif, France; Laboratory of Immunomonitoring in Oncology, UMS 3655 CNRS/US 23 INSERM, Gustave Roussy Cancer Campus, F-94805, Villejuif, France; University Paris-Saclay, Faculty of Pharmacy, Chatenay-Malabry, F-92296, France. Electronic address:

Introduction: Innate immunity represents the first step of activation of the immune system and dictates the quality of adaptive immune responses. Studies have reported links between systemic inflammatory or innate immune markers and prognosis in patients with lung cancer. To our knowledge, the prospective and concomitant study of these systemic markers has never been performed. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.017DOI Listing
January 2019

[Chronic myeloid leukemia presenting with marked eosinophilia].

Rinsho Ketsueki 2018 ;59(12):2594-2599

Department of Hematology, Tonan Hospital.

An 80-year-old female with fever, edema in the lower extremities, and marked eosinophilia was referred to our hospital. Based on the presence of the Philadelphia chromosome, she was diagnosed with chronic myeloid leukemia (CML). Although imatinib induced a complete cytogenetic response (CCyR), CML relapsed after 28 months of starting it. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2594/
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http://dx.doi.org/10.11406/rinketsu.59.2594DOI Listing
January 2018
2 Reads

Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still's disease.

Arthritis Res Ther 2019 Jan 7;21(1). Epub 2019 Jan 7.

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Shanghai, 200025, China.

Background: Adult-onset Still's disease (AOSD) is a systemic inflammatory disease characterized by neutrophilia and NLRP3 inflammasome and macrophage activation. We investigated the role of neutrophil extracellular traps (NETs) in the pathogenesis of AOSD, and explored the effect of NETs on activating NLRP3 inflammasome and proinflammatory macrophages.

Methods: The sera of 73 AOSD patients and 40 healthy controls were used to detect the level of cell-free DNA and NET-DNA complexes. Read More

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http://dx.doi.org/10.1186/s13075-018-1800-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323819PMC
January 2019
2 Reads

Clinicopathological findings in 41 dogs (2008-2018) naturally infected with Ehrlichia ewingii.

J Vet Intern Med 2019 Jan 2. Epub 2019 Jan 2.

Vector Borne Disease Diagnostic Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

Background: Ehrlichia ewingii is the most seroprevalent Ehrlichia-infecting dogs in the southern and mid-western United States. Fever, lameness, and polyarthritis are commonly reported findings in dogs naturally infected with E. ewingii. Read More

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http://dx.doi.org/10.1111/jvim.15354DOI Listing
January 2019

Rosai-Dorfman disease as a rare cause of cervical lymphadenopathy - case report and literature review.

Cent Eur J Immunol 2018 30;43(3):341-345. Epub 2018 Oct 30.

Department of Paediatrics, Haematology, and Oncology, University Clinical Centre in Gdansk, Poland.

Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, benign clinical entity of unknown cause. RDD is characterised by the overproduction and accumulation of histiocytes, primarily in the lymph nodes, although it may affect every organ and system. It predominantly affects children and young adults. Read More

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http://dx.doi.org/10.5114/ceji.2018.80055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305605PMC
October 2018

In vivo toxicological evaluation of polymer brush engineered nanoceria: impact of brush charge.

Nanotoxicology 2018 Dec 22:1-21. Epub 2018 Dec 22.

c 3 Laboratory of Nanobiotechnology, Department of Genetics and Morphology , Institute of Biological Sciences, University of Brasília , Brasília DF , Brazil.

Nanoceria has a broad variety of industrial and pharmacological applications due to its antioxidant activity. Nanoceria can be modified by surface coating with polyelectrolyte brushes. Brushes can increase the surface charge of nanoceria, providing greater aqueous stability while reducing agglomeration. Read More

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http://dx.doi.org/10.1080/17435390.2018.1543469DOI Listing
December 2018
2 Reads

Clodronate-Liposome treatment results in neutrophilia, anemia, and is not effective in limiting obesity-linked metabolic impairments.

Am J Physiol Endocrinol Metab 2018 Dec 21. Epub 2018 Dec 21.

Pathology, Microbiology & Immunology, University of South Carolina, United States.

Objective: Depletion of macrophages is thought to be a therapeutic option for obesity-induced inflammation and metabolic dysfunction. However, whether the therapeutic effect is a direct result of reduced macrophage-derived inflammation or secondary to decreases in fat mass is controversial as macrophage depletion has been shown to disrupt energy homeostasis. This study was designed to determine if macrophage depletion via clodronate-liposome (CLD) treatment could serve as an effective intervention to reduce obesity-driven inflammatory and metabolic impairments independent of changes in energy intake. Read More

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https://www.physiology.org/doi/10.1152/ajpendo.00438.2018
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http://dx.doi.org/10.1152/ajpendo.00438.2018DOI Listing
December 2018
4 Reads

Ibuprofen, a Potential Cause of Acute Hemorrhagic Gastritis in Children - A Case Report.

J Crit Care Med (Targu Mures) 2018 Oct 1;4(4):143-146. Epub 2018 Oct 1.

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania.

Introduction: Upper gastrointestinal bleeding is an uncommon but possible life-threatening entity in children, frequently caused by erosive gastritis. Non-steroidal anti-inflammatory drugs are one of the most common class of drugs which can cause gastrointestinal complications, including hemorrhagic gastritis.

Case Report: The case of a 6-year-old male, admitted for hematemesis, abdominal pain and loss of appetite. Read More

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http://content.sciendo.com/view/journals/jccm/4/4/article-p1
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http://dx.doi.org/10.2478/jccm-2018-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296277PMC
October 2018
9 Reads

Sweet Syndrome in Pediatrics. A case report.

Rev Chil Pediatr 2018 Aug;89(4):511-515

Servicio de Anatomía Patológica, Hospital Roberto del Río, Chile.

Introduction: Sweet's syndrome is a very rare dermatosis in pediatrics, of unknown pathogenesis, clinically characterized by fever, neutrophilia, raised and painful plaques on the skin of the face, neck, and limbs, and histologically by dermal infiltration of neutrophils.

Objective: To present a clinical case of Sweet Syndrome in a pediatric patient.

Clinical Case: 3-years-old female child, with history of complex chromosomopathy 46XX add(8), with a 7-day history of plaques and blisters on the back and later also on the limbs, associated with high fever, without response to antibiotic treatment pres cribed due to suspicion of bullous impetigo. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000603DOI Listing
August 2018
3 Reads

Benign pneumatosis intestinalis with massive portomesenteric venous gas in a very old man. A case report.

G Chir 2018 Nov-Dec;39(6):391-394

Introduction: Pneumatosis intestinalis (PI) is described as the presence of air within bowel wall. PI aetiology is various: it can be associated with non-urgent or life-threatening conditions. Clinical management is based on physical examination, blood tests and radiology, in particular abdominal CT. Read More

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December 2018

Teaching an Old Intensivist Neutrophil Tricks: Using Alveolar Neutrophilia to Diagnose Ventilator-Associated Pneumonia.

Am J Respir Crit Care Med 2018 Dec 13. Epub 2018 Dec 13.

Yale University, Pulmonary and Critical Care Medicine, New Haven, Connecticut, United States ;

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http://dx.doi.org/10.1164/rccm.201811-2163EDDOI Listing
December 2018

Zinc toxicosis in a dog secondary to prolonged zinc oxide ingestion.

Authors:
Jia Wen Siow

Open Vet J 2018 25;8(4):458-462. Epub 2018 Nov 25.

AEC Adelaide, 102 Magill Road, Norwood South Australia 5067, Australia.

Zinc toxicosis is commonly associated with ingestion of metallic zinc objects. This report documents an uncommon presentation of zinc toxicosis, secondary to prolonged ingestion of a zinc oxide cream. A 5. Read More

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http://dx.doi.org/10.4314/ovj.v8i4.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258521PMC
November 2018

In-DANBIRT Molecular Imaging of Inflammatory Cells in Atherosclerosis.

Contrast Media Mol Imaging 2018 13;2018:6508724. Epub 2018 Nov 13.

Radiopharmaceutical Sciences, University of New Mexico (UNM), Albuquerque, NM, USA.

Atherosclerosis-related morbidity and mortality remain a global concern. Atherosclerotic disease follows a slow and silent progression, and the transition from early-stage lesions to vulnerable plaques remains difficult to diagnose. Inflammation is a key component of the development of atherosclerotic plaque and consequent life-threatening complications. Read More

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http://dx.doi.org/10.1155/2018/6508724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257909PMC
November 2018
1 Read

Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation.

Front Immunol 2018 26;9:2718. Epub 2018 Nov 26.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environmental factors and characterized by airflow obstruction, wheezing, eosinophilia, and neutrophilia of lungs and sputum. Similar to other proinflammatory cytokines, IL-6 is elevated in asthma and plays an active role in this disease. However, the exact molecular mechanism of IL-6 involvement in the pathogenesis of asthma remains largely unknown and the major cellular source of pathogenic IL-6 has not been defined. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276801PMC
November 2018
2 Reads

Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice.

Toxicol Appl Pharmacol 2019 Feb 5;364:29-44. Epub 2018 Dec 5.

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

Nrf2 is essential to antioxidant response element (ARE)-mediated host defense. Sulforaphane (SFN) is a phytochemical antioxidant known to affect multiple cellular targets including Nrf2-ARE pathway in chemoprevention. However, the role of SFN in non-malignant airway disorders remain unclear. Read More

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http://dx.doi.org/10.1016/j.taap.2018.12.004DOI Listing
February 2019
1 Read

Schnitzler's syndrome: A female elderly case presenting intractable non-pruritic febrile urticarial rush.

Asian Pac J Allergy Immunol 2018 Dec 9. Epub 2018 Dec 9.

Graduate School of Medical Sciences, Department of Dermatology, Kyushu University, Fukuoka, Japan.

Schnitzler's syndrome is an acquired autoinflammatory disease characterized by chronic urticarial rash and monoclonal gammopathy (predominantly IgM type). A 75-year-old Japanese woman complained of high fever and non-pruritic urticarial rash appearing almost every day for 3 years. Her abnormal laboratory data included leukocytosis and neutrophilia with elevated erythrocyte sedimentation rate and C-reactive protein level. Read More

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http://dx.doi.org/10.12932/AP-150818-0394DOI Listing
December 2018
3 Reads

Novel roles for nasal epithelium in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Rhinology 2018 Dec 1. Epub 2018 Dec 1.

Otorhinolaryngology, Academic Medical Center, Amsterdam, the Netherlands.

Background: Airway epithelial cells have a well-accepted role in the regulation of local inflammatory processes in allergic and innate defence responses. However, their role the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) is unclear. The objective was to investigate whether potential differences in the mRNA expression profile of nasal epithelia from healthy individuals and from CRSwNP patients would shed new light on disease mechanisms. Read More

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http://dx.doi.org/10.4193/Rhin18.128DOI Listing
December 2018
1 Read

Transient receptor potential ion channels mediate adherens junctions dysfunction in a toluene diisocyanate-induced murine asthma model.

Toxicol Sci 2018 Dec 4. Epub 2018 Dec 4.

State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

Disruption of epithelial cell-cell junctions is essential for the initiation and perpetuation of airway inflammation in asthma. We've previously reported compromised epithelial barrier integrity in a toluene diisocyanate (TDI)-induced occupational asthma model. This study is aimed to explore the role of transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential ankyrin 1 (TRPA1) in the dysfunction of adherens junctions in TDI-induced asthma. Read More

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https://academic.oup.com/toxsci/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/toxsci/kfy285DOI Listing
December 2018
6 Reads

Colony-stimulating Factor 3 Receptor Mutated Chronic Neutrophilic Leukemia: A Rare Case Report.

Cureus 2018 Sep 18;10(9):e3326. Epub 2018 Sep 18.

Hematology and Oncology, Cleveland Clinic - Fairview Hospital, Cleveland, USA.

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm, which is characterized by sustained peripheral leukocytosis with neutrophilia, hepatosplenomegaly, and hypercellularity of the bone marrow, with less than 5% myeloblasts along with normal neutrophil maturation and no dysplasia. In 2016, World Health Organization (WHO) included activating mutations in the gene for colony-stimulating factor 3 receptor (CSF3R) as one of the diagnostic criteria with CSF3RT618I being the most common mutation. We report a rare case of CNL (JAK2V617F negative, BCR-ABL1 negative, CSF3RT618I positive) in an elderly female who had an aggressive clinical course of the disease. Read More

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http://dx.doi.org/10.7759/cureus.3326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248686PMC
September 2018
2 Reads

Chronic rhinosinusitis in elderly patients is associated with an exaggerated neutrophilic proinflammatory response to pathogenic bacteria.

J Allergy Clin Immunol 2018 Nov 22. Epub 2018 Nov 22.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tenn. Electronic address:

Background: Potential effects of aging on chronic rhinosinusitis (CRS) pathophysiology have not been well defined but might have important ramifications given a rapidly aging US and world population.

Objective: The goal of the current study was to determine whether advanced age is associated with specific inflammatory CRS endotypes or immune signatures.

Methods: Levels of 17 mucus cytokines and inflammatory mediators were measured in 147 patients with CRS. Read More

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http://dx.doi.org/10.1016/j.jaci.2018.10.056DOI Listing
November 2018
1 Read

TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.

J Clin Invest 2019 Jan 19;129(1):150-162. Epub 2018 Nov 19.

Department of Immunology and.

Pyrin is an inflammasome sensor that promotes caspase-1-mediated pyroptotic cell death and maturation of proinflammatory cytokines IL-1β and IL-18. Familial Mediterranean fever (FMF), an autoinflammatory disorder, is associated with mutations in the gene encoding pyrin (MEFV). FMF-knockin (FMF-KI) mice that express chimeric pyrin protein with FMF mutation (MefvV726A/V726A) exhibit an autoinflammatory disorder mediated by autoactivation of the pyrin inflammasome. Read More

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http://dx.doi.org/10.1172/JCI121372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307946PMC
January 2019
5 Reads

Sweet syndrome: a rare feature of ANCA-associated vasculitis or unusual consequence of azathioprine-induced treatment.

Allergy Asthma Clin Immunol 2018 8;14:46. Epub 2018 Nov 8.

1Division of Nephrology, Department of Medicine, University Hospital Limerick, St Nessans Rd, Limerick, Ireland.

Background: Sweet syndrome is a rare skin condition characterised by fever, neutrophilia, and tender erythematous skin lesions and has been reported to occur in association with anti-neutrophil cytoplasmic antibodies (ANCA) as well as complicate treatment with azathioprine therapy. Azathioprine, a relatively safe immunosuppressive, is frequently used to maintain disease remission in the treatment of ANCA-associated vasculitis. The occurrence of Sweet syndrome in a patient with ANCA-positive vasculitis and following treatment with azathioprine prompted us to present this clinical case and share this unusually rare occurrence. Read More

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http://dx.doi.org/10.1186/s13223-018-0265-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223070PMC
November 2018
2 Reads

Immune regulation and anti-cancer activity by lipid inflammatory mediators.

Int Immunopharmacol 2018 Dec 14;65:580-592. Epub 2018 Nov 14.

University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, United States of America. Electronic address:

Rodent and clinical studies have documented that myeloid cell infiltration of tumors is associated with poor outcomes, neutrophilia and lymphocytopenia. This contrasts with increased lymphocyte infiltration of tumors, which is correlated with improved outcomes. Lifestyle parameters, such as obesity and diets with high levels of saturated fat and/or omega (ω)-6 polyunsaturated fatty acids (PUFAs), can influence these inflammatory parameters, including an increase in extramedullary myelopoiesis (EMM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183092
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http://dx.doi.org/10.1016/j.intimp.2018.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322683PMC
December 2018
3 Reads

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.

Cell 2018 Nov 25;175(6):1634-1650.e17. Epub 2018 Oct 25.

McMaster Immunology Research Centre, M. G. DeGroote Institute for Infectious Disease Research, & Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, L8S 4K1, Canada. Electronic address:

Innate immune memory is an emerging area of research. However, innate immune memory at major mucosal sites remains poorly understood. Here, we show that respiratory viral infection induces long-lasting memory alveolar macrophages (AMs). Read More

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http://dx.doi.org/10.1016/j.cell.2018.09.042DOI Listing
November 2018
2 Reads

Neutrophilia and hyperamylasemia in patients with immediate food allergy.

Pediatr Int 2018 Nov 6. Epub 2018 Nov 6.

Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital, Shizuoka City, Shizuoka, Japan.

Background: Presently, little is known about laboratory findings several hours after oral food challenge (OFC) in patients with IgE-mediated immediate food allergy (FA).

Methods: One hundred and twelve subjects who underwent OFC at our institute between June 1, 2016, and March 31, 2018, were enrolled in this study. Changes in laboratory data several hours after OFC were examined. Read More

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http://dx.doi.org/10.1111/ped.13728DOI Listing
November 2018
10 Reads

Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia.

Am J Respir Crit Care Med 2018 Nov 6. Epub 2018 Nov 6.

Northwestern University, Chicago, Illinois, United States.

Rationale: The identification of informative elements of the host response to infection may improve the diagnosis and management of bacterial pneumonia.

Objective: To determine whether the absence of alveolar neutrophilia can exclude bacterial pneumonia in critically ill patients with suspected infection and to test whether signatures of bacterial pneumonia can be identified in the alveolar macrophage transcriptome.

Methods: We determined the test characteristics of alveolar neutrophilia for the diagnosis of bacterial pneumonia in 3 cohorts of mechanically ventilated patients. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201804-0650OC
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http://dx.doi.org/10.1164/rccm.201804-0650OCDOI Listing
November 2018
17 Reads

Direct Inhibitory Effect of the Phosphodiesterase-4 Inhibitor, Roflumilast, on Neutrophil Migration in COPD.

Am J Respir Cell Mol Biol 2018 Nov 5. Epub 2018 Nov 5.

Imperial Col. at the Nat. Hrt. & Lung In, London, United Kingdom of Great Britain and Northern Ireland ;

Neutrophilic inflammation is characteristic of COPD, yet there are no effective anti-inflammatory therapies. The phosphodiesterase (PDE)4 inhibitor, roflumilast is approved for use in COPD and suppresses sputum neutrophilia. The mechanism underlying this observation is unclear and therefore this study addressed whether roflumilast directly affected neutrophil migration. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2018-0065OC
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http://dx.doi.org/10.1165/rcmb.2018-0065OCDOI Listing
November 2018
4 Reads

Respiratory Infection Induce Release of Hepoxilin A and Histamine Production by Airway Neutrophils.

Front Immunol 2018 15;9:2357. Epub 2018 Oct 15.

Department of Microbiology, University of Massachusetts Amherst, Amherst, MA, United States.

Hepoxilins are biologically active metabolites of arachidonic acid that are formed through the 12-lipoxygenase pathway. Hepoxilin A is now known to be an important regulator of mucosal inflammation in response to infection by bacterial pathogens and was recently identified as a potent neutrophil chemoattractant in the intestinal mucosa. Our goal in this study was to determine if airway infection with in a murine model of allergic airway disease (AAD) induces hepoxilin secretion along with airway neutrophilia. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02357
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http://dx.doi.org/10.3389/fimmu.2018.02357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196283PMC
October 2018
4 Reads

Evaluation and correlation of oxidative stress and haemato-biochemical observations in horses with natural patent and latent trypanosomosis in Punjab state of India.

Acta Parasitol 2018 Dec;63(4):733-743

Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary & Animal Sciences University, Firozpur Road, Near Verka Milk Plant, Ludhiana, Punjab 141004, India.

The haemato-biochemical indices and oxidative stress markers in horses naturally infected with Trypanosoma evansi were evaluated by analyzing the level of these parameters between T. evansi infected (microscopically positive patent group and PCR positive latent group) and infection free horses. To compare the hemato-biochemical indices and oxidative stress indicators, horses were divided into three categories based on diagnostic test employed and positive results obtained. Read More

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http://www.degruyter.com/view/j/ap.2018.63.issue-4/ap-2018-0
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http://dx.doi.org/10.1515/ap-2018-0087DOI Listing
December 2018
12 Reads
0.960 Impact Factor

The roles of IL-17C in T cell-dependent and -independent inflammatory diseases.

Sci Rep 2018 Oct 24;8(1):15750. Epub 2018 Oct 24.

Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.

IL-17C, which is a member of the IL-17 family of cytokines, is preferentially produced by epithelial cells in the lung, skin and colon, suggesting that IL-17C may be involved in not only host defense but also inflammatory diseases in those tissues. In support of that, IL-17C was demonstrated to contribute to development of T cell-dependent imiquimod-induced psoriatic dermatitis and T cell-independent dextran sodium sulfate-induced acute colitis using mice deficient in IL-17C and/or IL-17RE, which is a component of the receptor for IL-17C. However, the roles of IL-17C in other inflammatory diseases remain poorly understood. Read More

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http://www.nature.com/articles/s41598-018-34054-x
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http://dx.doi.org/10.1038/s41598-018-34054-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200819PMC
October 2018
9 Reads

Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma.

Clin Exp Allergy 2018 Oct 24. Epub 2018 Oct 24.

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: Recent studies have demonstrated that Th2 responses have the ability to antagonize Th17 responses. In mouse models of allergic asthma, blockade of Th2-effector cytokines results in elaboration of Th17 responses and associated increases in pulmonary neutrophilia. While these can be controlled by simultaneous blockade of Th17-associated effector cytokines, clinical trials of anti-IL-17/IL-17RA blocking therapies have demonstrated increased of risk of bacterial and fungal infections. Read More

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http://dx.doi.org/10.1111/cea.13301DOI Listing
October 2018
2 Reads

Recent advances in understanding rhinovirus immunity.

F1000Res 2018 24;7. Epub 2018 Sep 24.

National Heart and Lung Institute, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, UK.

Rhinoviruses are the most common cause of upper respiratory tract infections. However, they can induce exacerbations of chronic obstructive pulmonary disease and asthma, bronchiolitis in infants, and significant lower respiratory tract infections in children, the immunosuppressed, and the elderly. The large number of rhinovirus strains (currently about 160) and their antigenic diversity are significant obstacles in vaccine development. Read More

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http://dx.doi.org/10.12688/f1000research.15337.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173106PMC
September 2018
1 Read

Association of CCL2 with systemic inflammation in Schnitzler syndrome.

Br J Dermatol 2018 Oct 19. Epub 2018 Oct 19.

Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology and, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Background: Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal gammopathy, which manifest mostly in the second half of life. It involves overactivation of the interleukin (IL)-1 system, but the exact pathophysiological pathways remain largely unknown.

Objectives: To identify and characterize the pathogenetic players in SchS. Read More

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http://dx.doi.org/10.1111/bjd.17334DOI Listing
October 2018
20 Reads

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment.

Science 2018 10;362(6412):351-356

Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Host injury triggers feedback mechanisms that limit tissue damage. Conventional type 1 dendritic cells (cDC1s) express dendritic cell natural killer lectin group receptor-1 (DNGR-1), encoded by the gene , which senses tissue damage and favors cross-presentation of dead-cell material to CD8 T cells. Here we find that DNGR-1 additionally reduces host-damaging inflammatory responses induced by sterile and infectious tissue injury in mice. Read More

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http://www.sciencemag.org/lookup/doi/10.1126/science.aan8423
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http://dx.doi.org/10.1126/science.aan8423DOI Listing
October 2018
16 Reads

Murine myeloproliferative disorder as a consequence of impaired collaboration between dendritic cells and CD4 T cells.

Blood 2018 Oct 17. Epub 2018 Oct 17.

VIB Center for Brain & Disease Research, Leuven, Belgium;

Dendritic cells (DCs) are a key cell type in the initiation of the adaptive immune response. Recently an additional role for DCs in suppressing myeloproliferation was discovered. Myeloproliferative disorder (MPD) was observed in both murine studies with constitutive depletion of DCs, and in patients with congenital deficiency in DCs caused by mutations in or The mechanistic link between DC deficiency and MPD was not predicted through the known biology and has remained an enigma. Read More

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http://dx.doi.org/10.1182/blood-2018-05-850321DOI Listing
October 2018
2 Reads

Lung Function Trajectory Types in Never-Smoking Adults With Asthma: Clinical Features and Inflammatory Patterns.

Allergy Asthma Immunol Res 2018 Nov;10(6):614-627

Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Purpose: Asthma is a heterogeneous disease that responds to medications to varying degrees. Cluster analyses have identified several phenotypes and variables related to fixed airway obstruction; however, few longitudinal studies of lung function have been performed on adult asthmatics. We investigated clinical, demographic, and inflammatory factors related to persistent airflow limitation based on lung function trajectories over 1 year. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2018.1
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http://dx.doi.org/10.4168/aair.2018.10.6.614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182203PMC
November 2018
4 Reads

Neutrophilia as prognostic biomarker in locally advanced stage III lung cancer.

PLoS One 2018 10;13(10):e0204490. Epub 2018 Oct 10.

Radiation oncology department, Gustave Roussy Cancer Campus, Villejuif, France.

Objective: To study the prognostic value of baseline leukocytosis or neutrophiliain two retrospective cohorts of stage III Non-Small Cell Lung Cancer (NSCLC) patients.

Materials And Methods: Clinical records of consecutive previously untreated NSCLC patients in our Institution between June 2001 and September 2016 for stage III NSCLC were collected. The prognostic value of pretreatment leucocyte disorders was examined, with focus on patterns of relapse and survival. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204490PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179235PMC
October 2018
10 Reads

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.

MBio 2018 Oct 9;9(5). Epub 2018 Oct 9.

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA

Acute respiratory distress syndrome (ARDS) is immune-driven pathologies that are observed in severe cases of severe acute respiratory syndrome coronavirus (SARS-CoV) infection. SARS-CoV emerged in 2002 to 2003 and led to a global outbreak of SARS. As with the outcome of human infection, intranasal infection of C57BL/6J mice with mouse-adapted SARS-CoV results in high-titer virus replication within the lung, induction of inflammatory cytokines and chemokines, and immune cell infiltration within the lung. Read More

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http://dx.doi.org/10.1128/mBio.01753-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178621PMC
October 2018
2 Reads

Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis.

Sci Rep 2018 Oct 5;8(1):14890. Epub 2018 Oct 5.

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria.

In polytrauma patients, the impact of splenectomy is equivocal, ranging from negative to protective. We investigated the impact of splenectomy on immune responses in the 1-hit polytrauma alone and on survival in the post-traumatic sepsis (2 hit). Female BALB/c mice underwent polytrauma (1 hit) consisting of either a) TH: femur fracture, hemorrhagic shock or b) TSH: splenectomy, femur fracture, hemorrhagic shock. Read More

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http://www.nature.com/articles/s41598-018-33232-1
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http://dx.doi.org/10.1038/s41598-018-33232-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173732PMC
October 2018
3 Reads

An old disease re-emerging: acute rheumatic fever.

Clin Med (Lond) 2018 Oct;18(5):400-402

Barts Health NHS Foundation Trust, London, UK.

We present the case of a 41-year-old Australian woman with a 3-day history of fevers and migratory polyarthritis. Three weeks prior she had been treated by her GP with phenoxymethylpenicillin for acute tonsillitis. Examination confirmed synovitis. Read More

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http://dx.doi.org/10.7861/clinmedicine.18-5-400DOI Listing
October 2018
1 Read
1.685 Impact Factor

Development of membranoproliferative glomerulonephritis-like glomerulopathy in a patient with neutrophilia resulting from endogenous granulocyte-colony stimulating factor overproduction: a case report.

BMC Nephrol 2018 Oct 4;19(1):251. Epub 2018 Oct 4.

Department of Nephrology and Endocrinology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Background: The pathophysiologic role of exogenous granulocyte-colony stimulating factor (G-CSF) administration is reportedly linked to the progression of glomerulonephritis. However, the relationship between endogenous G-CSF overproduction and the progression of glomerulopathy has not been well investigated.

Case Presentation: A 76-year-old woman presented with neutrophilia at a medical check-up and thorough examination revealed a high level of serum G-CSF. Read More

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http://dx.doi.org/10.1186/s12882-018-1049-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172840PMC
October 2018
2 Reads

Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis.

J Am Anim Hosp Assoc 2018 Nov/Dec;54(6):351-359. Epub 2018 Oct 1.

From the College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Champaign, Illinois.

Systemic inflammation is known to cause WBC abnormalities, specifically neutrophilia and lymphopenia. The neutrophil-to-lymphocyte ratio (NLR) is a simple and affordable biomarker that has been used in human clinical settings of sepsis but has not been investigated in veterinary species. We evaluated NLR in dogs with septic and nonseptic systemic inflammatory diseases and compared with a healthy dog population. Read More

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http://jaaha.org/doi/10.5326/JAAHA-MS-6808
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http://dx.doi.org/10.5326/JAAHA-MS-6808DOI Listing
October 2018
2 Reads

Utility of cell population data (VCS parameters) as a rapid screening tool for Acute Myeloid Leukemia (AML) in resource-constrained laboratories.

J Clin Lab Anal 2018 Sep 29:e22679. Epub 2018 Sep 29.

Lab Tech Manpower Ltd, Saint Petersburg, Russia.

Introduction: Despite advances in diagnostic techniques, many cases of acute myeloid leukemia (AML) remain underdiagnosed in remote centers unequipped with these technologies. We hypothesized that the automated cellular indices with scatter plots and flags may aid in rapid and cost-effective screening of AML.

Methods: Cell population data (CPD) parameters from 100 de novo AML samples were analyzed by Coulter LH 780 automated analyzer and were compared with 100 age-matched controls. Read More

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http://dx.doi.org/10.1002/jcla.22679DOI Listing
September 2018
9 Reads

Adult-onset Still's Disease in a Female Patient with Schizophrenia: A Case Report and Literature Review.

Cureus 2018 Jul 21;10(7):e3019. Epub 2018 Jul 21.

Internal Medicine, Icahn School of Medicine at Mount Sinai/Queens Hospital Center, New York, USA.

Adult-onset Still's disease (AOSD) is a rare diagnosis. In small percentage of cases, AOSD is associated with other autoimmune diseases including schizophrenia. Despite the lack of sufficient studies, both conditions may share similar autoimmune pathogenic pathways. Read More

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http://dx.doi.org/10.7759/cureus.3019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150749PMC
July 2018
4 Reads

Towards developing a valid scoring tool for bronchitis during flexible bronchoscopy.

Pediatr Pulmonol 2018 Nov 20;53(11):1510-1516. Epub 2018 Sep 20.

Department of Respiratory and Sleep Medicine, Lady Cilento Children's Hospital, Children Centre for Health Research, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: A valid bronchoscopic scoring tool for bronchitis would be useful for clinical and research purposes as currently there are none in children. From 100 digitally recorded flexible bronchoscopies (FB), we related the various macroscopic features to airway neutrophil % to develop a FB-derived bronchitis score (BScore ). We aimed to develop a FB-derived bronchitis tool. Read More

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http://dx.doi.org/10.1002/ppul.24163DOI Listing
November 2018
1 Read

Eicosanoid Control Over Antigen Presenting Cells in Asthma.

Front Immunol 2018 4;9:2006. Epub 2018 Sep 4.

Laboratory of Immunoregulation, VIB-UGent Center for Inflammation Research, Ghent, Belgium.

Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that leads to eosinophilic inflammation, reversible bronchoconstriction, and mucus overproduction. Other forms of asthma are controlled by an eosinophil-rich innate ILC2 response driven by epithelial damage, whereas in some patients with more neutrophilia, the disease is driven by Th17 cells. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131302PMC
September 2018
1 Read

Distinct β-glucan molecules modulates differently the circulating cortisol levels and innate immune responses in matrinxã (Brycon amazonicus).

Fish Shellfish Immunol 2018 Dec 13;83:314-320. Epub 2018 Sep 13.

Universidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, São Paulo, Brazil; Universidade Estadual Paulista (Unesp), Centro de Aquicultura da Unesp, Jaboticabal, São Paulo, Brazil. Electronic address:

This study investigated the effects of two β-glucan molecules with different purities and isolated by different biotechnological processes on the immune response of matrinxã (Brycon amazonicus) prior and after challenge with Aeromonas hydrophila. In this sense, we evaluated serum cortisol and plasma glucose levels, the number of leukocytes (lymphocytes, neutrophils and monocytes), as well as the respiratory activity of leukocytes prior to, 6 and 24 h post infection (hpi). During 15 days, fish were fed with diets containing 0. Read More

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http://dx.doi.org/10.1016/j.fsi.2018.09.042DOI Listing
December 2018
1 Read

SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration.

Eur Respir J 2018 Oct 4;52(4). Epub 2018 Oct 4.

Marsico Lung Institute, The University of North Carolina, Chapel Hill, NC, USA

The multi-organ disease cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane regulator gene () that lead to diminished transepithelial anion transport. CF lungs are characterised by airway surface liquid (ASL) dehydration, chronic infection/inflammation and neutrophilia. Dysfunctional CFTR may upregulate the epithelial Na channel (ENaC), further exacerbating dehydration. Read More

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http://dx.doi.org/10.1183/13993003.00668-2018DOI Listing
October 2018
12 Reads
7.640 Impact Factor

Serum sST2 levels predict severe exacerbation of asthma.

Respir Res 2018 Sep 3;19(1):169. Epub 2018 Sep 3.

Department of Respiratory Medicine, Kyorin University School of Medicine, 6-20-3 Sinkawa, Mitaka-city, Tokyo, 181-8612, Japan.

Background: Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We hypothesized that high serum sST2 levels in stable asthmatics are a predictor for exacerbation within a short duration. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
Publisher Site
http://dx.doi.org/10.1186/s12931-018-0872-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126416PMC
September 2018
9 Reads