3,724 results match your criteria Neutrophilia


Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11.

Mucosal Immunol 2020 May 26. Epub 2020 May 26.

Medical Research Council, Laboratory of Molecular Biology, Cambridge, Cambridgeshire, CB2 0QH, UK.

Type-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, and alternatively activated macrophages (AAM). However, despite the lack of neutrophil chemoattractants such as CXCL1, neutrophils, a feature of type-1 immunity, are observed in type-2 responses. Consequently, alternative mechanisms must exist to ensure that neutrophils can contribute to type-2 immune reactions without escalation of deleterious inflammation. Read More

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http://dx.doi.org/10.1038/s41385-020-0298-2DOI Listing

An IL17RA frameshift variant in a Holstein cattle family with psoriasis-like skin alterations and immunodeficiency.

BMC Genet 2020 May 24;21(1):55. Epub 2020 May 24.

Institute of Animal Breeding and Genetics, Faculty of Agricultural Sciences, Nutritional Sciences and Environmental Management, Justus-Liebig University Giessen, 35390, Giessen, Germany.

Background: Skin lesions and dermatoses in cattle are often associated with infections due to bacteria, fungi or environmental risk factors. Dermatoses with genetic etiology have been described in cattle. Among these rare disorders, there are primary congenital dermatoses that are associated with inherited nutritional deficiencies, such as bovine hereditary zinc deficiency or zinc deficiency-like syndrome. Read More

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http://dx.doi.org/10.1186/s12863-020-00860-4DOI Listing

Chronic neutrophilic leukemia presenting as secondary gout: Report of a rare myeloproliferative disorder.

Indian J Cancer 2020 Apr-Jun;57(2):201-204

Department of Clinical Hematology, Hemato-oncology and Bone Marrow (Stem Cell) Transplantation, Christian Medical College and Hospital, Ludhiana, Punjab, India.

Chronic neutrophilic leukemia is a rare leukemia seen in middle aged and elderly people, characterized by neutrophilic leukocytosis with no significant increase in granulocytic precursors. The chief criteria for diagnosis include total leukocyte count ≥25 × 109/L, >80% of white blood cells being mature neutrophils (segmented and band forms), immature granulocytic precursors ≥10% in the peripheral blood, and hypercellular marrow. In addition to this, there must be no evidence of dysplasia, monocytosis or BCR-ABL1, PDGFR-A, PDGFR-B, or FGRF-1 rearrangements. Read More

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http://dx.doi.org/10.4103/ijc.IJC_560_18DOI Listing

Myeloid neoplasm with a novel cryptic PDGFRB rearrangement detected by next-generation sequencing.

Cancer Genet 2020 May 3;244:55-59. Epub 2020 May 3.

Division of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 W 11(th) St, Indianapolis, IN 46202, USA. Electronic address:

Rearrangements of PDGFRB are defining cytogenetic abnormalities seen in "Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB" and are generally evident by common cytogenetic methods. Here we present an unique case in which karyotyping and fluorescence in situ hybridization (FISH) analysis were negative, and the PDGFRB rearrangement was detected by next-generation sequencing (NGS) analysis. The patient presented with approximately one-year history of leukocytosis including neutrophilia, eosinophilia, basophilia and granulocytic left shift. Read More

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http://dx.doi.org/10.1016/j.cancergen.2020.03.002DOI Listing

Clinical and pathological investigation of severe COVID-19 patients.

JCI Insight 2020 May 19. Epub 2020 May 19.

Department of Pathology and Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, China.

Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) caused coronavirus disease 2019 (COVID-19) has become a pandemic. This study addressed the clinical and immunopathological characteristics of severe COVID-19.

Methods: Sixty-nine COVID-19 patients were classified into as severe and non-severe groups to analyze their clinical and laboratory characteristics. Read More

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http://dx.doi.org/10.1172/jci.insight.138070DOI Listing

Analysis of Clinical and Laboratory Characteristics of Patients with Leptospirosis in Five-year Period.

Mater Sociomed 2020 Mar;32(1):15-19

Department of Urinary Infections, Zoonoses and Fever of Unknown Origin, Clinic for Infectious Diseases, University Clinical Center Tuzla, Bosnia and Herzegovina.

Introduction: Leptospirosis is an infection caused by spiral bacteria from the family Leptospiraceae, and is considered to be the most widespread zoonosis in the world.

Aim: To analyze the clinical and laboratory characteristics of patients with Leptospirosis over five years.

Methods: The study included 160 patients aged 17-79 years, who in the period 01. Read More

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http://dx.doi.org/10.5455/msm.2020.32.15-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224166PMC

Systemic Administration of Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia.

Mediators Inflamm 2020 25;2020:4620251. Epub 2020 Jan 25.

Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, 88040-970 SC-, Brazil.

Objective: The aim of this study was to investigate the anti-inflammatory effects of the crude extract (CE), derived fraction, and isolated compounds from leaves in a mouse model of pulmonary neutrophilia.

Methods: The CE and derived fractions, hexane, ethyl acetate, and methanol, were obtained from . leaves. Read More

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http://dx.doi.org/10.1155/2020/4620251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204167PMC
January 2020

The Clinical Characteristics and Outcomes of Diabetes Mellitus and Secondary Hyperglycaemia Patients with Coronavirus Disease 2019: a Single-center, Retrospective, Observational Study in Wuhan.

Diabetes Obes Metab 2020 May 14. Epub 2020 May 14.

Geriatrics Department of Peking University First Hospital, Beijing, China.

Aims: Since the pandemic outbreak of COVID-19, limited information is available on diabetic patients with COVID-19.

Materials And Methods: We retrospectively analysed 166 COVID-19 patients at Tongji Hospital (Wuhan) from February 8 to March 21, 2020. Clinical characteristics and outcomes (as of April 4, 2020) were compared among control (group 1), secondary hyperglycaemia (group 2: no diabetes history, FPG levels ≥7. Read More

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http://dx.doi.org/10.1111/dom.14086DOI Listing
May 2020
6.360 Impact Factor

Clinicopathological and radiographic features in 40 cats diagnosed with pulmonary and cutaneous infection (2012-2018).

J Feline Med Surg 2019 Nov 14:1098612X19886395. Epub 2019 Nov 14.

Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Malaysia.

Objectives: This retrospective study aimed to describe clinical manifestations, diagnostic options, radiological features, therapeutic plans and outcomes for cats infected with .

Methods: Forty cats aged between 2 months and 11 years old (median 6 months) that were definitively diagnosed with rhodococcosis between 2012 and 2018 were recruited in this study. Medical records were reviewed for information on signalment, history, clinical presentation, diagnostic testing, treatment plans and clinical outcomes. Read More

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http://dx.doi.org/10.1177/1098612X19886395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206563PMC
November 2019

Deep Vein Thrombosis and Pulmonary Embolism: Two Complications of COVID-19 Pneumonia?

Eur J Case Rep Intern Med 2020 8;7(5):001646. Epub 2020 Apr 8.

Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.

Coronavirus disease 19 (COVID-19) is a worldwide infection which was recently declared a global health emergency by the WHO Emergency Committee. The most common symptoms are fever and cough, which can progress to pneumonia, acute respiratory distress syndrome (ARDS) and/or end-organ failure. Risk factors associated with ARDS and death are older age, comorbidities (e. Read More

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http://dx.doi.org/10.12890/2020_001646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213837PMC

Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis.

Antioxidants (Basel) 2020 May 8;9(5). Epub 2020 May 8.

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.

In this era, worldwide interest has been directed towards using natural antioxidants to guard against drug side effects. is a famous medicinal plant with many biologically active compounds. Triamcinolone acetonide (TA) is an extensively used glucocorticoid. Read More

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http://dx.doi.org/10.3390/antiox9050396DOI Listing

Asymmetrical Pulmonary Cytokine Profiles Are Linked to Bronchoalveolar Lavage Fluid Cytology of Horses With Mild Airway Neutrophilia.

Front Vet Sci 2020 24;7:226. Epub 2020 Apr 24.

LABÉO Frank Duncombe, Caen, France.

Few data on cytokine profiles in bronchoalveolar lavage fluid (BALF) are available for racehorses with mild/moderate equine asthma (EA); cytological diagnosis being most frequently made from only one lung. The purpose of the study was to compare cytokine mRNA expressions and protein concentrations in BALF from both lungs. As part of a larger study, 250 ml saline was randomly instilled in one lung and 500 ml in the contralateral lung of 30 clinically healthy Standardbred racehorses. Read More

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http://dx.doi.org/10.3389/fvets.2020.00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193537PMC

Cardiogenic shock elicits acute inflammation, delayed eosinophilia, and depletion of immune cells in most severe cases.

Sci Rep 2020 May 6;10(1):7639. Epub 2020 May 6.

Service of Adult Intensive Care Medicine, University Hospital Medical Center and Faculty of Biology and Medicine, Lausanne, Switzerland.

Patients with cardiogenic shock (CS) display systemic inflammation and a high rate of infections, suggesting important immune disturbances. To explore the immune response to CS, we prospectively measured, in 24 consecutive CS patients, differential white blood cell (WBC) counts and the cytokines IL-1β, IL-5, IL-6, IL-10, TNFα, IFNγ, MCP-1 and eotaxin (CCL11), at Day 1 (T1), day 3 (T2) and day 6-8 (T3). Secondary infections and their influence on cytokines and WBCs were determined. Read More

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http://dx.doi.org/10.1038/s41598-020-64702-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203157PMC

Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Hospitalized Patients in Wuhan, China.

Clin Infect Dis 2020 May 3. Epub 2020 May 3.

Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.

Background: With evidence of sustained transmission in more than 190 countries, coronavirus disease 2019 (COVID-19) has been declared a global pandemic. Data are urgently needed about risk factors associated with clinical outcomes.

Methods: A retrospective review of 323 hospitalized patients with COVID-19 in Wuhan was conducted. Read More

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http://dx.doi.org/10.1093/cid/ciaa539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197620PMC

DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation.

Int Immunopharmacol 2020 Apr 27;84:106542. Epub 2020 Apr 27.

Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan. Electronic address:

Acute lung injury (ALI) is a severe disease characterized by several inflammatory responses in the lung with high mortality. We applied a mouse model of the pulmonary inflammation induced by the intratracheal instillation of bleomycin which is widely used to induce ALI and fibrosis in animal models. We hypothesized that DNA methyltransferase inhibitor, 5-azacytidine (5-Aza), with its anti-inflammatory benefits, might attenuate bleomycin-induced ALI through the alleviation of inflammation in the lung. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106542DOI Listing

Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China.

Crit Care 2020 04 30;24(1):188. Epub 2020 Apr 30.

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.

Background: In December 2019, coronavirus disease 2019 (COVID-19) outbreak was reported from Wuhan, China. Information on the clinical course and prognosis of COVID-19 was not thoroughly described. We described the clinical courses and prognosis in COVID-19 patients. Read More

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http://dx.doi.org/10.1186/s13054-020-02895-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192564PMC

Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort.

J Immunother Cancer 2020 Apr;8(1)

Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background: The biological underpinnings of the prognostic and predictive significance of a relative neutrophilia in patients with non-small lung cancer (NSCLC) are undefined. We sought to comprehensively examine the relationships between circulating and intratumoral neutrophil populations and features of the immune contexture in patients undergoing NSCLC resection.

Methods: Preoperative soluble cytokine and angiogenic factors; tumor multiplex immunofluorescence; RNA, whole exome, and T-cell receptor sequencing; and flow cytometry were analyzed for relationships with populations of circulating (from complete blood counts) and intratumoral neutrophils (transcriptional signatures) in a prospectively enrolled resected NSCLC cohort (n=66). Read More

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http://dx.doi.org/10.1136/jitc-2019-000405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213906PMC

Cholesterol-25-hydroxylase promotes efferocytosis and resolution of lung inflammation.

JCI Insight 2020 Apr 28. Epub 2020 Apr 28.

Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, United States of America.

Alveolar macrophages (AM) play a central role in initiation and resolution of lung inflammation, but the integration of these opposing core functions is poorly understood. AM expression of cholesterol-25-hydroxylase (CH25H), the primary biosynthetic enzyme for 25-hydroxycholesterol (25HC), far exceeds that of macrophages in other tissues, but no role for CH25H has been defined in lung biology. As 25HC is an agonist for the anti-inflammatory nuclear receptor, Liver X Receptor (LXR), we speculated that CH25H might regulate inflammatory homeostasis in the lung. Read More

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http://dx.doi.org/10.1172/jci.insight.137189DOI Listing

Predictors of a good response to inhaled corticosteroids in obesity-associated asthma.

Biochem Pharmacol 2020 Apr 23:113994. Epub 2020 Apr 23.

Department of Pulmonary Medicine, CHU Sart-Tilman, Liege, I(3) GIGA Research Group, University of Liege, Belgium. Electronic address:

Introduction: Asthma in obese subjects is poorly understood. According to GINA guidelines, pulmonologists increase ICS in case of poor asthma control but lung volume restriction may also worsen respiratory symptoms in obese asthmatics leading to overtreatment in this subpopulation.

Methods: We conducted a retrospective study on 1217 asthmatics recruited from University Hospital of Liege. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.113994DOI Listing

RSV Reprograms the CDK9•BRD4 Chromatin Remodeling Complex to Couple Innate Inflammation to Airway Remodeling.

Authors:
Allan R Brasier

Viruses 2020 Apr 22;12(4). Epub 2020 Apr 22.

Institute for Clinical and Translational Research; University of Wisconsin-Madison School of Medicine and Public Health; Madison, WI 53705, USA.

Respiratory syncytial virus infection is responsible for seasonal upper and lower respiratory tract infections worldwide, causing substantial morbidity. Self-inoculation of the virus into the nasopharynx results in epithelial replication and distal spread into the lower respiratory tract. Here, respiratory syncytial virus (RSV) activates sentinel cells important in the host inflammatory response, resulting in epithelial-derived cytokine and interferon (IFN) expression resulting in neutrophilia, whose intensity is associated with disease severity. Read More

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http://dx.doi.org/10.3390/v12040472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232410PMC

Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells.

PLoS One 2020 24;15(4):e0225560. Epub 2020 Apr 24.

Department of Science and Technology, Federal University of São Paulo, São José dos Campos, São Paulo, Brazil.

COPD is a prevalent lung disease with significant impacts on public health. Affected airways exhibit pulmonary neutrophilia and consequent secretion of pro-inflammatory cytokines and proteases, which result in lung emphysema. Probiotics act as nonspecific modulators of the innate immune system that improve several inflammatory responses. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225560PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182195PMC

Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis.

Front Immunol 2020 9;11:596. Epub 2020 Apr 9.

Faculty of Health and Medical Sciences, School of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia.

The responses of cystic fibrosis (CF) airway epithelial cells (AEC) to rhinovirus (RV) infection are likely to contribute to early pathobiology of lung disease with increased neutrophilic inflammation and lower apoptosis reported. Necrosis of AEC resulting in airway inflammation driven by IL-1 signaling is a characteristic finding in CF detectable in airways of young children. Being the most common early-life infection, RV-induced epithelial necrosis may contribute to early neutrophilic inflammation in CF via IL-1 signaling. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161373PMC

In vivo and in vitro inflammatory responses to fine particulate matter (PM) from China and California.

Toxicol Lett 2020 Aug 19;328:52-60. Epub 2020 Apr 19.

Center for Health and the Environment, University of California, Davis, USA. Electronic address:

Ambient PM was collected during the winter season from Taiyuan, Shanxi, China; Jinan, Shandong, China; and Sacramento, California, USA, and used to create PM, PM, and PM extracts, respectively. Time-lag experiments were performed to explore the in vivo and in vitro toxicity of the PM extracts. In vivo inflammatory lung responses were assessed in BALB/c mice using a single oropharyngeal aspiration (OPA) of PM extract or vehicle (CTRL) on Day 0. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.04.010DOI Listing
August 2020
3.262 Impact Factor

Epidemiology of Tick-Borne Relapsing Fever in Endemic Area, Spain.

Emerg Infect Dis 2020 May;26(5):849-856

Tick-borne relapsing fever (TBRF) is caused by spirochetes of Borrelia bacteria. We collected data on all TBRF cases in a TBRF-endemic area in southwest Spain during 1994-2016. We analyzed data from 98 patients in whom TBRF was diagnosed by light microscopy and analyzed the relationship between climatic data and TBRF incidence. Read More

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http://dx.doi.org/10.3201/eid2605.190745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181924PMC

Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma.

Clin Exp Allergy 2020 Apr 15. Epub 2020 Apr 15.

Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia.

Background: Mast cells (MCs) are innate immune cells that regulate atopic and non-atopic inflammation in the airways. MCs play a critical role in the pathogenesis of asthma, yet their relationship to airway and systemic inflammation and clinical characteristics of asthma is poorly understood.

Objective: To quantify MCs in induced sputum samples and understand their relationship to airway and circulatory immune cells, and clinical variables in asthma. Read More

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http://dx.doi.org/10.1111/cea.13609DOI Listing

Clinical characteristics of the BREATHE cohort - a real-life study on patients with asthma and COPD.

Eur Clin Respir J 2020 17;7(1):1736934. Epub 2020 Mar 17.

Respiratory Medicine and Allergology, Clinical Sciences Lund, Lund University, Lund, Sweden.

The BREATHE study is a cross-sectional study of real-life patients with asthma and/or COPD in Denmark and Sweden aiming to increase the knowledge across severities and combinations of obstructive airway disease. Patients with suspicion of asthma and/or COPD and healthy controls were invited to participate in the study and had a standard evaluation performed consisting of questionnaires, physical examination, FeNO and lung function, mannitol provocation test, allergy test, and collection of sputum and blood samples. A subgroup of patients and healthy controls had a bronchoscopy performed with a collection of airway samples. Read More

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http://dx.doi.org/10.1080/20018525.2020.1736934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144315PMC

Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD.

J Allergy Clin Immunol 2020 Apr 10. Epub 2020 Apr 10.

National Heart and Lung Institute, Imperial College, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom. Electronic address:

Background: Respiratory viral infection causes chronic obstructive pulmonary disease (COPD) exacerbations. We previously reported increased bronchial mucosa eosinophil and neutrophil inflammation in patients with COPD experiencing naturally occurring exacerbations. But it is unclear whether virus per se induces bronchial mucosal inflammation, nor whether this relates to exacerbation severity. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173046PMC

β2 Integrin Gene (ITGB2) mutation spectra in Pakistani families with leukocyte adhesion deficiency type 1 (LAD1).

Immunobiology 2020 Apr 2:151938. Epub 2020 Apr 2.

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Biochemistry CMH, Kharian Medical College, Pakistan. Electronic address:

Leukocyte adhesion deficiency I (LADI) is an autosomal recessive type of primary immunodeficiency characterized by occurrence of repeated bacterial infections, impaired pus formation and wound healing. Genetic variations in the β-2 integrin subunit encoding gene ITGB2 have been implicated in causing the disorder. In the present study, we have investigated twelve patients presenting LAD1 features. Read More

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http://dx.doi.org/10.1016/j.imbio.2020.151938DOI Listing
April 2020
3.044 Impact Factor

Ginsenoside Rg3 ameliorates acute exacerbation of COPD by suppressing neutrophil migration.

Int Immunopharmacol 2020 Jun 8;83:106449. Epub 2020 Apr 8.

Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China; Key laboratory of Zoonosis Research Ministry of Education, Jilin University, Changchun 130021, China. Electronic address:

Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) is an irreversible inflammatory airways disease responsible for global health burden, involved with a complex condition of immunological change. Exacerbation-mediated neutrophilia is an important factor in the pathogenesis of cigarette smoke-induced AECOPD. Ginsenoside Rg3, a red-ginseng-derived compound, has multiple pharmacological properties such as anti-inflammatory and antitumor activities. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106449DOI Listing

A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum gram-negative antimicrobial coverage.

Clin Infect Dis 2020 Apr 8. Epub 2020 Apr 8.

NHS Lothian Infection Service, Regional Infectious Diseases Unit, Western General Hospital, Edinburgh, U.K.

Amongst 200 patients developing HAP outwith the ICU, 61% were treated empirically without broad-spectrum gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers(SIRS, hypoxia, tachypnoea, neutrophilia) and absence of diabetes mellitus and prior doxycycline treatment (but not time to HAP onset) identified patients not requiring broad-spectrum gram-negative coverage. Read More

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http://dx.doi.org/10.1093/cid/ciaa391DOI Listing

Is neutrophilia the key to diagnosing appendicitis in pregnancy?

Am J Surg 2020 May 26;219(5):855-859. Epub 2020 Mar 26.

Division of General Surgery, Providence Health Care, St Paul's Hospital, Room C303-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada. Electronic address:

Background: The diagnosis of acute appendicitis (AA) in pregnancy remains challenging. We investigated which preoperative clinical factors are most predictive of AA in pregnant women.

Methods: 164 pregnant patients undergoing magnetic resonance imaging for suspected AA were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.03.018DOI Listing

Allergen-specific subcutaneous immunotherapy for Japanese cedar pollinosis decreases the number of metachromatic cells and eosinophils in nasal swabs during the preseason and in season.

Immun Inflamm Dis 2020 Apr 2. Epub 2020 Apr 2.

Otorhinolaryngology and Head and Neck Surgery, Nippon Medical School, Tokyo, Japan.

Background And Objective: Nasal symptoms of allergic rhinitis can be reduced with allergen-specific subcutaneous immunotherapy (SCIT). However, the mechanisms underlying the effectiveness of SCIT for Japanese cedar pollinosis are not well understood. We studied changes in the numbers of metachromatic cells, eosinophils and neutrophils in nasal swabs following SCIT for Japanese cedar pollinosis. Read More

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http://dx.doi.org/10.1002/iid3.301DOI Listing

Blood Parameters Demonstrating a Significant Survival Impact in Patients With Locally Advanced NSCLC Undergoing Definitive Chemoradiotherapy.

Anticancer Res 2020 Apr;40(4):2319-2322

Department of Radiotherapy and Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.

Aim: We investigated blood parameters in patients with inoperable stage III non-small cell lung cancer (NSCLC) to predict individual outcomes after definitive chemoradiotherapy (CRT).

Patients And Methods: Blood parameters of consecutive patients undergoing definitive CRT between 2010 and 2016 for inoperable stage III NSCLC before multimodal treatment and at first follow-up were measured and analyzed.

Results: Blood parameters from 99 patients were evaluated. Read More

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http://dx.doi.org/10.21873/anticanres.14198DOI Listing

Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils.

Mucosal Immunol 2020 Mar 13. Epub 2020 Mar 13.

i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

Modulation of immunity and disease by glycans is increasingly recognized. However, how host glycosylation shapes and is shaped by tuberculosis remains poorly understood. We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a key enzyme for core-2 O-glycans biosynthesis, drives susceptibility to Mycobacterium tuberculosis infection. Read More

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http://dx.doi.org/10.1038/s41385-020-0277-7DOI Listing

STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation.

Cytokine 2020 Mar 19;130:155059. Epub 2020 Mar 19.

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, Victoria 3168, Australia. Electronic address:

Deregulated activation of the latent transcription factor STAT3 has been implicated in the pathogenesis of myeloproliferative and lymphoproliferative hematologic disorders. The uncontrolled activation of STAT3 has traditionally been assigned to its elevated phosphorylation at tyrosine 705 (pY) and associated nuclear transcriptional activity. By contrast, a transcriptional role for serine 727 phosphorylation (pS) of STAT3 has recently emerged, suggesting that pS may account for the pathological activity of STAT3 in certain disease settings. Read More

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http://dx.doi.org/10.1016/j.cyto.2020.155059DOI Listing

Latrodectism in Italy: First report of successful treatment of L. tredecimguttatus envenomation using L. mactans antivenom from North America.

Toxicon 2020 May 13;179:107-110. Epub 2020 Mar 13.

Salvatore Maugeri Foundation Scientific Institute of Pavia Via Maugeri, Italy.

Introduction: Latrodectism is a rare, but potentially severe, clinical syndrome caused by spider of the genus Latrodectus. L. tredecimguttatus is widespread in Italy and its bite cause the injection of α-latrotoxin that cause depletion of acetylcholine at motor nerve endings and release of catecholamines at adrenergic nerve endings. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.03.002DOI Listing

Clinical characteristics, treatment, and outcome for cattle that developed retroperitoneal abscesses following paralumbar fossa laparotomy: 32 cases (1995-2017).

J Am Vet Med Assoc 2020 Apr;256(7):814-821

Objective: To describe the clinical and clinicopathologic characteristics, treatment, and outcome for cattle that developed a retroperitoneal abscess (RA) following paralumbar fossa laparotomy (PFL).

Animals: 32 Holstein cows with RA.

Procedures: The record database of a veterinary teaching hospital was searched to identify cattle that were treated for an RA between January 1995 and March 2017. Read More

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http://dx.doi.org/10.2460/javma.256.7.814DOI Listing

Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation.

J Infect 2020 05 20;80(5):e14-e17. Epub 2020 Mar 20.

Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. Electronic address:

Objectives: Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. However, limited data was available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102560PMC

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China.

JAMA Intern Med 2020 Mar 13. Epub 2020 Mar 13.

Department of Pulmonary Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.

Importance: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated.

Objective: To describe the clinical characteristics and outcomes in patients with COVID-19 pneumonia who developed acute respiratory distress syndrome (ARDS) or died. Read More

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http://dx.doi.org/10.1001/jamainternmed.2020.0994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070509PMC

Association between acute histopathological changes of rectal walls and late radiation proctitis following radiotherapy for prostate cancer.

Strahlenther Onkol 2020 Mar 12. Epub 2020 Mar 12.

Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy.

Purpose: The impact of acute histopathological changes (HC) of the rectum on development of late clinical proctitis (LCP) after external radiotherapy (RT) for prostate cancer is poorly explored and was the primary end point of this prospective study.

Methods: In 70 patients, 15 HC of early rectal biopsies after RT were identified, whereby RT was conventional 2D RT in 41 cases and conformational 3D RT in 29. Associations of HC in anterior and posterior rectal walls (ARW, PRW) with LCP, acute endoscopic (AEP) and acute clinical proctitis (ACP) were statistically evaluated considering as explicative variables the patient general characteristics and the HC. Read More

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http://dx.doi.org/10.1007/s00066-020-01590-3DOI Listing

18F-FDG PET/CT Findings in a Patient With Neutrophilic Leukemoid Reaction Associated With Multiple Myeloma.

Clin Nucl Med 2020 May;45(5):405-406

From the Departments of Nuclear Medicine.

F-FDG PET/CT was performed on a 48-year-old woman with leukocytosis (white blood cell count 57.10 × 10/L, 84.0% neutrophils) and monoclonal gammopathy to investigate the possibility of reactive neutrophilia secondary to plasmacytoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002999DOI Listing

The long-term oral exposure to titanium dioxide impaired immune functions and triggered cytotoxic and genotoxic impacts in rats.

J Trace Elem Med Biol 2020 Jul 21;60:126473. Epub 2020 Feb 21.

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Background: Titanium dioxide "TiO, E171″ is a widely used food additive that exists in various everyday food products all over the world together with vast applications in cosmetics and industry. However, many toxicological aspects particularly following oral exposure still unclear.

Methods: Hence, this study was planned to examine the effect of oral exposure of male Wistar rats to two doses of TiO (20 or 40 mg/kg b. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126473DOI Listing

Mortal consequences of a cooperative action between Takotsubo syndrome and increased intracranial pressure.

ESC Heart Fail 2020 Mar 6. Epub 2020 Mar 6.

Department of Emergency Medicine, Pineta Grande Hospital, Caserta, 81030, Italy.

An elderly patient with head injury was registered to the emergency room. Because the patient arrived to the hospital unconscious, her cranial, cerebrovascular, and cardiac function was studied. The cardiac function measurements were (i) heart rate, (ii) blood pressure, (iii) oxygen saturation level, (iv) electrocardiogram (ECG), (v) coronary angiogram, (vi) chest computerized tomography (CT), and (vii) echocardiogram. Read More

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http://dx.doi.org/10.1002/ehf2.12601DOI Listing

Chemokine, cytokine and haematological profiles in Sprague-Dawley rats co-infected with ANKA and -A laboratory animal model for malaria and tissue-dwelling nematodes co-infection.

Heliyon 2020 Feb 25;6(2):e03475. Epub 2020 Feb 25.

School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.

Malaria remains a major cause of mortality and morbidity in sub-Saharan Africa (SSA) and tissue-dwelling helminth parasites (TDHPs) are also prevalent in this region presenting a geographical overlap in endemicity. There is paucity of information on the specific host immune responses elicited at different phases of the life cycle by the co-infecting helminth parasites. This study aimed at using a laboratory animal model to determine selected chemokine, cytokine and hematological profiles in Sprague-Dawley rats co-infected with ANKA (Pb) and a tissue-dwelling nematode, (Tz). Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044667PMC
February 2020

Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe Mice.

Cardiovasc Drugs Ther 2020 Apr;34(2):145-152

Division of Molecular Medicine, Department of Medicine, Columbia University Medical Center, 630 W. 168th Street, New York, NY, 10032, USA.

Objective: Increased myelopoiesis has been linked to risk of atherosclerotic cardiovascular disease (ACD). Excessive myelopoiesis can be driven by dyslipidemia and cholesterol accumulation in hematopoietic stem and progenitor cells (HSPC) and may involve increased signaling via Janus kinase 2 (JAK2). Constitutively activating JAK2 mutants drive biased myelopoiesis and promote development of myeloproliferative neoplasms (MPN) or clonal hematopoiesis, conditions associated with increased risk of ACD. Read More

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http://dx.doi.org/10.1007/s10557-020-06943-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125070PMC
April 2020
3.189 Impact Factor

R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability.

BMC Res Notes 2020 Feb 4;13(1):54. Epub 2020 Feb 4.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.

Objective: R-spondin 2 (RSPO2) is required for lung morphogenesis, activates Wnt signaling, and is upregulated in idiopathic lung fibrosis. Our objective was to investigate whether RSPO2 is similarly important in homeostasis of the adult lung. While investigating the characteristics of bronchoalveolar lavage in RSPO2-deficient (RSPO2) mice, we observed unexpected changes in neutrophil homeostasis and vascular permeability when compared to control (RSPO2) mice at baseline. Read More

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http://dx.doi.org/10.1186/s13104-020-4930-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001225PMC
February 2020

Rosuvastatin suppresses cytokine production and lung inflammation in asthmatic, hyperlipidemic and asthmatic-hyperlipidemic rat models.

Cytokine 2020 Apr 31;128:154993. Epub 2020 Jan 31.

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Given the role that T lymphocytes play on the pathogenesis of allergic asthma, drugs targeting Th2 and Th17 cells may be a hopeful therapeutic strategy. This study aimed to evaluate the effect of rosuvastatin treatment on cytokine production and lung inflammation in allergic asthma.

Methods: The animals were assigned into control (C), asthmatic (A), hyperlipidemic (H), asthmatic-hyperlipidemic (AH), rosuvastatin (40 mg/kg/day intraperitoneally, for 3 weeks)-treated asthmatic (AR), rosuvastatin-treated hyperlipidemic (HR) and rosuvastatin-treated asthmatic-hyperlipidemic (AHR) groups (n = 6 in each group). Read More

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http://dx.doi.org/10.1016/j.cyto.2020.154993DOI Listing

Acute tea tree oil intoxication in a pet cockatiel (Nymphicus hollandicus): a case report.

BMC Vet Res 2020 Jan 31;16(1):29. Epub 2020 Jan 31.

Department of Veterinary Science, University of Parma, Parma (PR), Italy.

Background: Phytotherapy is becoming a more and more common practice, not only for personal care but also for pet care. Nevertheless, we often have to deal with substances on which, in most cases, very little literature is available, even more so if the species of interest are the exotic ones. In particular, the essential oil from the Melaleuca leaves, because of its antinflammatory and antibacterial properties, is widely used and very little is known about its potential toxicity on pet birds. Read More

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http://dx.doi.org/10.1186/s12917-020-2255-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995176PMC
January 2020

Paraneoplastic Leukemoid Reaction in Gastroesophageal Junction Adenocarcinoma: A Case Report.

Am J Case Rep 2020 Jan 31;21:e919596. Epub 2020 Jan 31.

Department of Gastroenterology, Spectrum Health Lakeland , Saint Joseph, MI, USA.

BACKGROUND The presence of leukocytosis associated with non-hematological malignancy after ruling out other causes is defined as paraneoplastic leukemoid reaction (PLR). PLR is a rare manifestation of various solid tumors. It is associated with poor prognosis unless receiving effective antineoplastic treatments. Read More

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http://dx.doi.org/10.12659/AJCR.919596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011169PMC
January 2020

Pancreatic abscess within hepato-gastric ligament: case report of an extremely rare disease.

BMC Surg 2020 Jan 30;20(1):20. Epub 2020 Jan 30.

Department of General surgery, BSMCH, Bankura, West Bengal, PIN-722102, India.

Background: Pancreatic pseudocyst is a very common benign cystic lesion of the pancreas. It develops in 5-15% of patients with peri-pancreatic fluid collection following acute pancreatitis. Collection usually occurs within the lesser sac of the omentum (near the pancreatic head and body region). Read More

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http://dx.doi.org/10.1186/s12893-020-0688-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993323PMC
January 2020