3,995 results match your criteria Neutrophilia

Recurrent Severe Preschool Wheeze: From Pre-Specified Diagnostic Labels to Underlying Endotypes.

Am J Respir Crit Care Med 2021 May 7. Epub 2021 May 7.

Royal Brompton Hospital, Respiratory Paediatrics, London, United Kingdom of Great Britain and Northern Ireland;

Rationale: Preschool wheezing is heterogeneous, but the underlying mechanisms are poorly understood.

Objectives: To investigate lower airway inflammation and infection in preschool children with different clinical diagnoses undergoing elective bronchoscopy/bronchoalveolar lavage-BAL.

Methods: We recruited 136 children aged 1-5 years (105 recurrent severe wheeze-RSW; 31 non-wheeze respiratory disorders-NWRD). Read More

View Article and Full-Text PDF

Dynamic and features of SARS-CoV-2 infection in Gabon.

Sci Rep 2021 May 6;11(1):9672. Epub 2021 May 6.

Unité de Recherche et Diagnostics Spécialisé, Service Laboratoire, CHU-Mère-EnfantFondation Jeanne EBORI, Libreville, Gabon.

In a context where SARS-CoV-2 population-wide testing is implemented, clinical features and antibody response in those infected have never been documented in Africa. Yet, the information provided by analyzing data from population-wide testing is critical to understand the infection dynamics and devise control strategies. We described clinical features and assessed antibody response in people screened for SARS-CoV-2 infection. Read More

View Article and Full-Text PDF

Leukocyte Adhesion Deficiency Type 1 Due to Novel ITGB2 Mutation.

Ir Med J 2020 Jul 30;113(7):129. Epub 2020 Jul 30.

Department of Paediatrics, Cork University Hospital, Cork, Republic of Ireland.

Aim Marked neutrophilia and omphalitis in an infant resulted in the diagnosis of the first case of leukocyte adhesion deficiency type 1 (LAD1) in Ireland. Diagnosis LAD1 requires specific molecular diagnostics for its correct identification. Results Early identification of this disorder allowed for rapid referral for haemotopoeitic stem cell transplant which has resulted in an excellent outcome for this patient. Read More

View Article and Full-Text PDF

Glucagon-like peptide-1 receptor agonist inhibits aeroallergen-induced activation of ILC2 and neutrophilic airway inflammation in obese mice.

Allergy 2021 May 6. Epub 2021 May 6.

Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Background: Obesity is a risk factor for the development of asthma. However, pharmacologic therapeutic strategies that specifically target obese asthmatics have not been identified. We hypothesize that glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment inhibitsaeroallergen-induced early innate airway inflammation in a mouse model of asthma in the setting of obesity. Read More

View Article and Full-Text PDF

Invariant Natural Killer T Cells as Key Players in Host Resistance against .

J Immunol Res 2021 16;2021:6673722. Epub 2021 Apr 16.

Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.

Invariant Natural Killer T (iNKT) cells are key players in the immunity to several pathogens; however, their involvement in the resistance to infection remains unknown. Using splenocytes from CD1d (CD1d) and iNKT-deficient (J18) mice, we found that iNKT cells are the innate source of IFN- after infection and are required to potentiate macrophage oxidative burst and control fungal growth. To determine whether iNKT cells contribute to host resistance against infection, we infected intratracheally wild-type and J18 C57BL/6 mouse strains with the virulent Pb18 isolate. Read More

View Article and Full-Text PDF

Traumatic jejunal perforation associated with SARS-CoV-2 (COVID-19) infection.

Proc (Bayl Univ Med Cent) 2021 Jan 28;34(3):364-366. Epub 2021 Jan 28.

Department of Medical Education, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Several case reports have suggested that COVID-19 may increase the risk of gastrointestinal perforation. We report a case of a gastrointestinal perforation developing in a COVID-19 patient who presented due to injuries from a motor vehicle accident. On admission, the patient had elevated white blood cells, with neutrophilia and lymphopenia. Read More

View Article and Full-Text PDF
January 2021

Cervical adenitis caused by in a newborn.

BMJ Case Rep 2021 May 5;14(5). Epub 2021 May 5.

Department of Neonatology, Maternidade Doutor Daniel de Matos, Centro Hospitalar e Universitário de Coimbra, EPE, Coimbra, Portugal.

Cervical acute lymphadenitis is rarely described in neonates. We present the case of a 12-day-old preterm, fed by nasogastric tube, who presented a tender erythematous submandibular swelling. Laboratory data showed neutrophilia and an elevation of C reactive protein and procalcitonin. Read More

View Article and Full-Text PDF

Clinico-epidemiology of Hypnale zara (hump-nosed pit viper) envenoming in Sri Lanka.

Trans R Soc Trop Med Hyg 2021 May 4. Epub 2021 May 4.

Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka.

Background: Hump-nosed vipers of the genus Hypnale are the most common cause of venomous snakebites in Sri Lanka. The genus includes three species: Hypnale hypnale, Hypnale zara and Hypnale nepa. Of them, H. Read More

View Article and Full-Text PDF

Predictors of the response to nivolumab immunotherapy in the second or subsequent lines for metastatic non-small cell lung cancers.

Exp Ther Med 2021 Jun 14;21(6):605. Epub 2021 Apr 14.

Department of Oncology, 'Gr. T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.

Checkpoint inhibitors represent the first therapeutic class to replace chemotherapy lines for the treatment of metastatic non-small cell lung cancer (NSCLC), due to improved overall survival and tolerability. Nivolumab, a fully human anti-programmed cell death-1 immunoglobulin G4 monoclonal antibody, is the first immune checkpoint inhibitor approved by the US Food and Drug Administration in 2014 for cases of metastatic melanoma and in 2015 for cases of squamous cell lung cancer and kidney cell cancer. The present study aimed to identify predictive markers (favorable or unfavorable) for time to treatment discontinuation using nivolumab in the second or subsequent line of therapy of metastatic NSCLC cases. Read More

View Article and Full-Text PDF

Lymphoplasmacytic and eosinophilic enteritis with or without globule leukocyte hyperplasia in 4 goats.

J Vet Intern Med 2021 May 2. Epub 2021 May 2.

Department of Pathology, Microbiology and Immunology, University of California Davis School of Veterinary Medicine, Davis, California, USA.

Four, mature, client-owned goats were presented to referral hospitals for recurrent diarrhea despite treatment for intestinal parasitism. Common clinical findings included diarrhea, poor condition, neutrophilia, and hypoalbuminemia. Testing for common infectious causes of diarrhea in goats was negative. Read More

View Article and Full-Text PDF

Predictors of readmission requiring hospitalization after discharge from emergency departments in patients with COVID-19.

Am J Emerg Med 2021 Apr 22;46:146-149. Epub 2021 Apr 22.

Emergency Unit, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", Ancona, Italy.

Introduction: Little is known on prevalence of early return hospital admission of subjects with COVID-19 previously evaluated and discharged from emergency departments (EDs). This study aims to describe readmission rate within 14 days of patients with COVID-19 discharged from ED and to identify predictors of return hospital admission.

Methods: We performed a retrospective cohort study of adult patients with COVID-19 discharged from two EDs. Read More

View Article and Full-Text PDF

Repeated exposure of house dust mite induces progressive airway inflammation in mice: Differential roles of CCL17 and IL-13.

Pharmacol Res Perspect 2021 May;9(3):e00770

Discovery Immunology, Janssen Research & Development, LLC, Spring House, PA, USA.

We conducted a systematic evaluation of lung inflammation indued by repeated intranasal exposure (for 10 consecutive days) to a human aeroallergen, house dust mite (HDM) in BALB/c mice. Peak influx of neutrophils, monocytes/lymphocytes, and eosinophils was observed in bronchoalveolar lavage (BAL) on days 1, 7 and 11, respectively, and normalized to baseline by day 21. Peak elevations of Th2, myeloid-derived cytokines/chemokines and serum IgE were seen both in BAL and lung tissue homogenates between days 7 and 11, and declined thereafter; however, IL-33 levels remained elevated from day 7 to day 21. Read More

View Article and Full-Text PDF

A Case of Chronic Neutrophilic Leukemia Incidentally Detected by F-FDG PET/CT.

Diagnostics (Basel) 2021 Apr 5;11(4). Epub 2021 Apr 5.

Division of Laboratory Medicine, Veterans Health Service Medical Center, 61 Jinhwangdoro-gil 53, Gangdong-gu, Seoul 05368, Korea.

Chronic neutrophilic leukemia (CNL) is a rare, potentially aggressive, myeloproliferative neoplasm. To the best of our knowledge, there are no previous reports dealing with F-FDG PET findings in CNL. We describe a case of CNL in a 69-year-old male, imaged with F-FDG PET/CT at diagnosis and during treatment. Read More

View Article and Full-Text PDF

Astragalin Inhibits Cigarette Smoke-Induced Pulmonary Thrombosis and Alveolar Inflammation and Disrupts PAR Activation and Oxidative Stress-Responsive MAPK-Signaling.

Int J Mol Sci 2021 Apr 1;22(7). Epub 2021 Apr 1.

Department of Food and Nutrition and Korean Institute of Nutrition, Hallym University, Chuncheon 24252, Korea.

Epidemiological evidence shows that smoking causes a thrombophilic milieu that may play a role in the pathophysiology of chronic obstructive pulmonary disease (COPD) as well as pulmonary thromboembolism. The increased nicotine level induces a prothrombotic status and abnormal blood coagulation in smokers. Since several anticoagulants increase bleeding risk, alternative therapies need to be identified to protect against thrombosis without affecting hemostasis. Read More

View Article and Full-Text PDF

Novel Treatment-Refractory Preschool Wheeze Phenotypes Identified by Cluster Analysis of Lung Lavage Constituents.

J Allergy Clin Immunol Pract 2021 Apr 24. Epub 2021 Apr 24.

Division of Allergy, Asthma, and Immunology, Department of Medicine, University of Virginia School of Medicine; Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA.

Background: Preschool children with treatment-refractory wheeze often require unscheduled acute care. Current guidelines advise treatment of persistent wheeze with inhaled corticosteroids (ICS). Alternative treatments targeting structural abnormalities and specific inflammatory patterns could be more effective. Read More

View Article and Full-Text PDF

The Association of Age, Sex, and RT-PCR Results with the Lymphocyte and Neutrophil Counts in SARS-CoV-2 Infection: A Cross-sectional Analysis of 1450 Iranian Patients with COVID-19.

Iran J Allergy Asthma Immunol 2021 Apr 17;20(2):129-139. Epub 2021 Apr 17.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Containment of pandemic infections mainly depends on prompt identification of carriers, achievable through strict surveillance and truthful diagnostic testing. Although molecular identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard method, its low sensitivity and long turnaround time are among major concerns. In this retrospective single-center study, we reviewed the results of the lymphocyte and neutrophil counts of 1450 Iranian patients with coronavirus disease 2019 (COVID-19) recruited at Baqiyatallah Hospital, Tehran, Iran. Read More

View Article and Full-Text PDF

COVID-19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony-stimulating factor (G-CSF) support: A case report.

Mol Clin Oncol 2021 Jun 8;14(6):117. Epub 2021 Apr 8.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Patients receiving chemotherapy are at high risk for severe infections and complications such as acute respiratory syndrome. The most commonly used adjuvant chemotherapy protocols (docetaxel-cyclophosphamide every 3 weeks or the dose-dense regimen, doxorubicin-cyclophosphamide every 2 weeks followed by paclitaxel) incorporate granulocyte-colony stimulating factor (G-CSF). G-CSF is routinely administered to prevent chemotherapy-associated neutropenia but often results in significant neutrophilia. Read More

View Article and Full-Text PDF

Adsorptivity of mercury on magnetite nano-particles and their influences on growth, economical, hemato-biochemical, histological parameters and bioaccumulation in Nile tilapia (Oreochromis niloticus).

Aquat Toxicol 2021 Apr 20;235:105828. Epub 2021 Apr 20.

Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Zagazig University, P.O. Box 44511, Zagazig, Sharkia, Egypt.

Among toxic pollutants, Mercury (Hg) is a toxic heavy metal that induces harmful impacts on aquatic ecosystems directly and human being's health indirectly. This study confirmed the in vitro magnetic potential of magnetite Nano-Particles (FeO NPs) against waterborne Hg exposure-induced toxicity in Nile tilapia (Oreochromis niloticus). We further evaluate the safety profile of FeO NPs on fish growth, hemato-biochemical, histological parameters, bioaccumulation in muscles, and economy. Read More

View Article and Full-Text PDF

Mapping atopic dermatitis and anti-IL-22 response signatures to Type 2-low severe neutrophilic asthma.

J Allergy Clin Immunol 2021 Apr 20. Epub 2021 Apr 20.

Clinical and Experimental Sciences and Human Development in Health, University of Southampton Faculty of Medicine, Southampton; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton; and David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight. UK.

Background: Transcriptomic changes in patients who respond clinically to biological therapies may identify responses in other tissues or diseases.

Objective: To determine whether a disease signature identified in atopic dermatitis (AD) is seen in adults with severe asthma (SA) and whether a transcriptomic signature for AD patients who respond clinically to anti-IL-22 (Fezakinumab, FZ) is enriched in SA.

Methods: An AD disease signature was obtained from analysis of differentially expressed genes (DEGs) between AD lesional and non-lesional skin biopsies. Read More

View Article and Full-Text PDF

Differential alteration trend of white blood cells (WBCs) and monocytes count in severe and non-severe COVID-19 patients within a 7-day follow-up.

Iran J Microbiol 2021 Feb;13(1):8-16

Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Objectives: Several studies have focused on the alterations of hematological parameters for a better understanding of the COVID-19 pathogenesis and also their potential for predicting disease prognosis and severity. Although some evidence has indicated the prognostic values of thrombocytopenia, neutrophilia, and lymphopenia, there are conflicting results concerning the leukocyte and monocyte count.

Materials And Methods: In this retrospective Double Centre study, we reviewed the results of WBC and monocyte counts of 1320 COVID-19 patients (243 of whom (18. Read More

View Article and Full-Text PDF
February 2021

Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia.

Front Immunol 2021 29;12:645741. Epub 2021 Mar 29.

Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.

Particulate matter (PM) induces neutrophilic inflammation and deteriorates the prognosis of diseases such as cardiovascular diseases, cancers, and infections, including COVID-19. Here, we addressed the role of γδ T cells and intestinal microbiome in PM-induced acute neutrophilia. γδ T cells are a heterogeneous population composed of Tγδ1, Tγδ2, Tγδ17, and naïve γδ T cells (TγδN) and commensal bacteria promote local expansion of Tγδ17 cells, particularly in the lung and gut without affecting their Vγ repertoire. Read More

View Article and Full-Text PDF

Impact of copper and zinc mixture on haematological parameters of rainbow trout (Oncorhynchus mykiss): acute exposure and recovery.

Ecotoxicology 2021 Apr 13. Epub 2021 Apr 13.

Nature Research Centre, Institute of Ecology, Akademijos Str. 2, LT-08412, Vilnius, Lithuania.

Significant changes in composition of rainbow trout Oncorhynchus mykiss blood cells types were induced after 4-days exposure with mixture of Cu and Zn at 0.25, 0.125 and 0. Read More

View Article and Full-Text PDF

Pattern of inflammatory immune response determines the clinical course and outcome of COVID-19: unbiased clustering analysis.

Sci Rep 2021 04 13;11(1):8080. Epub 2021 Apr 13.

Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

The objective of the study was to identify distinct patterns in inflammatory immune responses of COVID-19 patients and to investigate their association with clinical course and outcome. Data from hospitalized COVID-19 patients were retrieved from electronic medical record. Supervised k-means clustering of serial C-reactive protein levels (CRP), absolute neutrophil counts (ANC), and absolute lymphocyte counts (ALC) was used to assign immune responses to one of three groups. Read More

View Article and Full-Text PDF

A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19.

Sci Rep 2021 04 13;11(1):8062. Epub 2021 Apr 13.

Department of General Surgery, Shiyan Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25. Read More

View Article and Full-Text PDF


Am J Physiol Heart Circ Physiol 2021 Apr 12. Epub 2021 Apr 12.

INCLIVA Health Research Institute. Valencia, Spain; Department of Medicine, School of Medicine, University of Valencia. Valencia, Spain; Centro de Investigación Biomédica en Red - Cardiovascular; Cardiology Department. Hospital Clinico Universitario. Valencia, Spain.

The outbreak of severe acute respiratory syndrome coronavirus 2 that first emerged in Wuhan in December 2019 has resulted in the devastating pandemic of coronavirus disease 2019, creating an emerging need for knowledge sharing. Meanwhile, myocardial infarction is and will probably remain the foremost cause of death in the western world throughout the coming decades. Severe deregulation of the immune system can unnecessarily expand the inflammatory response and participate in target and multiple organ failure, in infection but also in critical illness. Read More

View Article and Full-Text PDF

Dust exposure and pulmonary inflammation in Standardbred racehorses fed dry hay or haylage: A pilot study.

Vet J 2021 May 13;271:105654. Epub 2021 Mar 13.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison St., West Lafayette, IN 47907, USA.

Respirable dust exposure is linked to airway inflammation in racehorses. Feeding haylage may reduce dust exposure by 60-70%. The objective of this study was to compare dust exposure, airway cytology, and inflammatory cytokine concentrations between horses fed haylage or hay over 6 weeks while in training. Read More

View Article and Full-Text PDF

Early hematological indicators of severe COVID-19 disease in hospitalized patients: Data from a South Asian population.

Int J Lab Hematol 2021 Apr 9. Epub 2021 Apr 9.

Section of Hematology, Department of Pathology, Shifa International Hospital, Islamabad, Pakistan.

Introduction: Outbreak of corona virus disease in 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Our aim is to document hematological parameters of patients with COVID-19 during initial stage of diagnosis and to identify early hematological indicators of severe infection.

Materials And Methods: This retrospective study was conducted at Shifa International Hospital, Pakistan from April to November 2020. Read More

View Article and Full-Text PDF

Comparison and clinical characteristics of COVID-19 between January and February 2020 in Wuhan, China.

Ann Palliat Med 2021 Mar 23. Epub 2021 Mar 23.

Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) continues to make a deadly impact on human life all over the world. Therefore, we aimed to analyze the changes in clinical characteristics of coronavirus disease 2019 (COVID-19) patients over time.

Methods: We recruited 896 patients who were admitted to the Renmin Hospital of Wuhan University between 30th January 2020 and 16st March 2020. Read More

View Article and Full-Text PDF

Asymptomatic SARS-CoV-2 infection- Incidental findings on FDG PET/CT.

J Med Imaging Radiat Sci 2021 Mar 16. Epub 2021 Mar 16.

Division of Nuclear Medicine; Department of Radiology, Icahn School of Medicine at Mount Sinai; 1 Gustave L. Levy Pl, New York, NY 10029, United States. Electronic address:

Rationale And Objectives: Identify the incidental findings of Covid-19 pneumonitis on F-FDG PET/CT scan in asymptomatic oncologic patients. The goal was to detect clinically unsuspected Covid-19 infections to prevent community spread.

Materials And Methods: Retrospective analysis was conducted to recognize the pattern of metabolic and radiographic alterations on F-FDG PET/CT scans in Covid-19 patients. Read More

View Article and Full-Text PDF

mRNA-lncRNA Co-Expression Network Analysis Reveals the Role of lncRNAs in Immune Dysfunction during Severe SARS-CoV-2 Infection.

Viruses 2021 03 3;13(3). Epub 2021 Mar 3.

Cancer Genomics and BioComputing of Complex Diseases Lab, Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

The recently emerged SARS-CoV-2 virus is responsible for the ongoing COVID-19 pandemic that has rapidly developed into a global public health threat. Patients severely affected with COVID-19 present distinct clinical features, including acute respiratory disorder, neutrophilia, cytokine storm, and sepsis. In addition, multiple pro-inflammatory cytokines are found in the plasma of such patients. Read More

View Article and Full-Text PDF