3,544 results match your criteria Neutrophilia


Cervical hyperaesthesia in dogs: an epidemiological retrospective study of 185 cases.

J Small Anim Pract 2019 Mar 13. Epub 2019 Mar 13.

Dick White Referrals, Six Mile Bottom, Cambridgeshire CB8 0UH, UK.

Objectives: To describe the prevalence, clinical findings and predictors of disease in dogs with cervical hyperaesthesia.

Materials And Methods: Medical records of dogs referred for neurological investigation of cervical hyperaesthesia between 2009 and 2013 were retrospectively reviewed. Dogs were assigned to one of the following groups according to the final diagnosis: Non-Neurologic, Brain, Cervical Spine, Multifocal, and Chiari-like Malformation/Syringomyelia. Read More

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http://dx.doi.org/10.1111/jsap.12987DOI Listing
March 2019
2 Reads

Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial.

Int J Cancer 2019 Mar 14. Epub 2019 Mar 14.

Department of Radiotherapy and Oncology, University of Frankfurt, Germany.

Peripheral blood leukocytosis and neutrophilia reflect cancer inflammation and have been proposed as prognostic immunological biomarkers in various malignancies. However, previous studies were limited by their retrospective nature and small patient numbers. Baseline peripheral blood leukocytes, neutrophils, hemoglobin, platelets, lactate dehydrogenase and carcinoembryonic antigen (CEA) were correlated with clinicopathologic characteristics, and clinical outcome in 1236 patients with rectal cancer treated with 5-FU-based preoperative chemoradiotherapy (CRT) alone or with oxaliplatin followed by surgery and adjuvant chemotherapy within the CAO/ARO/AIO-04 randomized phase 3 trial. Read More

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http://dx.doi.org/10.1002/ijc.32274DOI Listing
March 2019
2 Reads

A prospective study of hospitalized patients with leukemoid reaction; causes, prognosis and value of manual peripheral smear review.

Rom J Intern Med 2019 Mar 11. Epub 2019 Mar 11.

Department of Internal Medicine, General Hospital of Heraklion "Venizeleio-Pananeio".

Introduction: Several diagnoses have been associated with leukemoid reaction (LR). In patients with LR the diagnostic and prognostic value of detailed manual blood smear counts (such as the percentage of band cells or grading of neutrophil toxic changes) has not been studied previously.

Methods: We prospectively recorded all hospitalized adult (>18 years old) patients with LR (≥30000/ul) of neutrophilic predominance, excluding patients with pre-existing leukocytosis due to hematological malignancies. Read More

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http://dx.doi.org/10.2478/rjim-2019-0006DOI Listing
March 2019
1 Read

Presentation of hemolytic and hemorrhagic rangeliosis in Cerdocyon thous.

Ticks Tick Borne Dis 2019 Feb 22. Epub 2019 Feb 22.

Laboratório de Diagnóstico em Medicina Veterinária, Universidade de Caxias do Sul, R. Francisco Getúlio Vargas, 1130, Petrópolis, Caxias do Sul, RS, 95070560, Brazil. Electronic address:

Rangeliosis, caused by protozoan Rangelia vitalii, is transmitted by the tick Amblyomma aureolatum. The disease is characterized by hemolytic and hemorrhagic disorder and has been described in dogs and other wild canids. The aim of this study was to compare clinicopathological findings and laboratory results of a Rangelia infection in a crab-eating fox (Cerdocyon thous) with those of canine rangeliosis. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.02.010DOI Listing
February 2019
1 Read

Modulation of the lung inflammatory response to ozone by the estrous cycle.

Physiol Rep 2019 Mar;7(5):e14026

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Emerging evidence suggests that sex differences exist in the control of lung innate immunity; however, the specific roles of sex hormones in the inflammatory response, and the mechanisms involved are unclear. Here, we investigated whether fluctuations in circulating hormone levels occurring in the mouse estrous cycle could affect the inflammatory response to air pollution exposure. For this, we exposed female mice (C57BL/6J, 8 weeks old) at different phases of the estrous cycle to 2 ppm of ozone or filtered air (FA) for 3 h. Read More

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http://dx.doi.org/10.14814/phy2.14026DOI Listing
March 2019
1 Read

Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization.

PLoS Pathog 2019 Mar 7;15(3):e1007381. Epub 2019 Mar 7.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.

The intestinal microbiota influences the development and function of myeloid lineages such as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic zebrafish, we identified the immune effector Serum amyloid A (Saa) as one of the most highly induced transcripts in digestive tissues following microbiota colonization. Saa is a conserved secreted protein produced in the intestine and liver with described effects on neutrophils in vitro, however its in vivo functions remain poorly defined. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007381DOI Listing
March 2019
1 Read

Age-Dependent Pulmonary Reactivity to House Dust Mite Allergen: A Model of Adult-Onset Asthma?

Am J Physiol Lung Cell Mol Physiol 2019 Mar 6. Epub 2019 Mar 6.

Center for Health and the Environment, University of California, Davis, United States.

Asthma is a heterogeneous disease differentiated by factors like allergen sensitivity, inflammation, sex, and onset age. The mouse model is widely used for studying the early life development of allergic asthma. However, age-dependent allergen responses later in life remain relatively understudied and lack a widely accepted model. Read More

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http://dx.doi.org/10.1152/ajplung.00468.2018DOI Listing
March 2019
2 Reads

Type I leucocyte adhesion deficiency in Yemenian family managed with appropriate treatment: A case series.

Dermatol Ther 2019 Mar 5:e12864. Epub 2019 Mar 5.

Department of dermatology, University of Science and Technology Hospital, Sana'a, Yemen.

Primary immunodeficiencies are rare, inherited diseases, characterized by altered function or absence of immune cells. Among them is leukocyte adhesion deficiency Type I (LAD-I), an autosomal recessive disorder characterized by primary immunodeficiency, caused by mutations in the ITGB2 gene which produces inability of leucocytes to migrate toward the area of inflammation and is associated with recurrent life-threatening bacterial and fungal infections. Pyoderma gangrenosum (PG) is an uncommon noninfectious neutrophilic dermatosis, characterized by recurrent, necrotic ulcers. Read More

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http://dx.doi.org/10.1111/dth.12864DOI Listing
March 2019
1 Read

Clinical characteristics and outcome in patients with antisynthetase syndrome associated interstitial lung disease: a retrospective cohort study.

Eur Clin Respir J 2019 27;6(1):1583516. Epub 2019 Feb 27.

Department of Respiratory Diseases, Sydvestjydsk Regional Hospital, Esbjerg, Denmark.

: To describe the clinical characteristics including the bronchoalveolar lavage fluid (BALF) characteristics of patients with antisynthetase syndrome (AS) associated interstitial lung disease (ILD) in a tertiary ILD outpatient clinic, their medical therapy and outcome. : Retrospective cohort study of patients with AS-ILD. All available data of clinical characteristics, pulmonary function tests, laboratory parameters, BALF analysis, histology, high-resolution computed tomography (HRCT) and treatment were collected from the patient files. Read More

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http://dx.doi.org/10.1080/20018525.2019.1583516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394310PMC
February 2019
2 Reads

Nasal Symptoms Reduction and Decreased Neutrophilia in Japanese Cedar Pollinosis With Prophylactic Treatment With a Combination of Montelukast, Fexofenadine, and Fluticasone Nasal Spray.

Am J Rhinol Allergy 2019 Mar 1:1945892419831924. Epub 2019 Mar 1.

4 Department of Otorhinolaryngology and Head and Neck Surgery, Nippon Medical School, Tokyo, Japan.

Background And Objective: We reported neutrophil-associated tissue damage in cedar pollinosis subjects with refractory nasal symptoms prior to pollinosis season. Because the leukotriene receptor antagonist, montelukast, can inhibit neutrophil recruitment and activation, we investigated its effects on symptom relief and nasal neutrophilia in pollinosis subjects in the preseason.

Methods: In the pollinosis preseason, symptomatic (PreSyP, n = 149) and asymptomatic subjects (PreAsP, n = 145) were prophylactically treated, and in season symptomatic subjects (InSyP, n = 134) were treated. Read More

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http://dx.doi.org/10.1177/1945892419831924DOI Listing

Paraneoplastic disorders associated with miscellaneous neoplasms with focus on selected soft tissue and Undifferentiated/ rhabdoid malignancies.

Authors:
Abbas Agaimy

Semin Diagn Pathol 2019 Feb 20. Epub 2019 Feb 20.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Germany. Electronic address:

A variety of soft tissue and visceral neoplasms have been associated with constitutional symptoms and signs including fever, fatigue, arthritis and laboratory abnormalities such as elevated erythrocyte sedimentation rate, leukocytosis with marked neutrophilia, anemia, thrombocytosis and others. This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions). Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.001DOI Listing
February 2019
2 Reads

Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity.

J Leukoc Biol 2019 Feb 28. Epub 2019 Feb 28.

Immunology Section, Department of Medicine, University of Udine, Udine, Italy.

The receptor tyrosine kinase cKit and its ligand stem cell factor are essential for mast cells (MC) development and survival. Strains with mutations affecting the Kit gene display a profound MC deficiency in all tissues and have been extensively used to investigate the role of MC in both physiologic and pathologic conditions. However, these mice present a variety of abnormalities in other immune cell populations that can affect the interpretation of MC-related responses. Read More

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http://doi.wiley.com/10.1002/JLB.4HI1018-390R
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http://dx.doi.org/10.1002/JLB.4HI1018-390RDOI Listing
February 2019
2 Reads

Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.

Oncogene 2019 Feb 28. Epub 2019 Feb 28.

Institute of General Pharmacology and Toxicology, pharmazentrum frankfurt /ZAFES, Hospital of the Goethe University, Frankfurt, Germany.

A role of sphingolipids for inflammatory bowel disease and cancer is evident. However, the relative and separate contribution of sphingolipid deterioration in inflammation versus carcinogenesis for the pathophysiology of colitis-associated colon cancer (CAC) was unknown and therefore examined in this study. We performed isogenic bone marrow transplantation of inducible sphingosine-1-phosphate (S1P) lyase knockout mice to specifically modulate sphingolipids and associated genes and proteins in a compartment-specific way in a DSS/AOM mediated CAC model. Read More

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http://dx.doi.org/10.1038/s41388-019-0758-xDOI Listing
February 2019
2 Reads

Antitumoral effect of maintained neutrophilia induced by rhG-CSF in a murine model of pancreatic cancer.

Sci Rep 2019 Feb 27;9(1):2879. Epub 2019 Feb 27.

Department of Hematology, Hospital de la Sant Creu i Sant Pau, Institute of Biomedical Research, IIB-Sant Pau, Barcelona, Spain.

Although the protumoral functions of polymorphonuclear neutrophils are well known, some now-forgotten studies report antitumoral roles for these cells. The present work examines the antitumoral effect of maintained neutrophilia induced via the injection of recombinant human granulocyte colony stimulating factor (rhG-CSF, 100 μg/kg/day) in a Panc-1 subcutaneous xenograft murine model of pancreatic cancer. This treatment was compared with gemcitabine administration (120 mg/kg every two days) and a saline control (n = 6-7 mice per group). Read More

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http://dx.doi.org/10.1038/s41598-019-39805-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393423PMC
February 2019

Immature granulocytes index as early marker of sepsis.

Int J Lab Hematol 2019 Feb 26. Epub 2019 Feb 26.

Pontifícia Universidade Católica of Rio Grande do Sul - PUCRS, Porto Alegre, Brazil.

Introduction: Sepsis induces the recruitment of immature neutrophils into the circulation. An immature granulocyte percentage (IG%) count greater than 3% has been shown to be an indicator for the risk of sepsis. The aim of this study was to evaluate the IG% as predictor of sepsis compared to blood culture results and sepsis diagnostic confirmation. Read More

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http://dx.doi.org/10.1111/ijlh.12990DOI Listing
February 2019
1 Read

NETopathic Inflammation in Chronic Obstructive Pulmonary Disease and Severe Asthma.

Front Immunol 2019 5;10:47. Epub 2019 Feb 5.

Pulmonary Research Institute at LungenClinic, Großhansdorf, Germany.

Neutrophils play a central role in innate immunity, inflammation, and resolution. Unresolving neutrophilia features as a disrupted inflammatory process in the airways of patients with chronic obstructive pulmonary disease (COPD) and severe asthma. The extent to which this may be linked to disease pathobiology remains obscure and could be further confounded by indication of glucocorticoids or concomitant respiratory infections. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370641PMC
February 2019
2 Reads

The IFN-γ-p38, ERK kinase axis exacerbates neutrophilic chronic rhinosinusitis by inducing the epithelial-to-mesenchymal transition.

Mucosal Immunol 2019 Feb 25. Epub 2019 Feb 25.

Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea.

Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial inflammatory disease characterized by involvement of diverse types of inflammatory cells. Asian CRS patients frequently show infiltration of neutrophils and an elevated level of interferon (IFN)-γ; by contrast, western patients exhibit eosinophil infiltration and enhanced levels of Th2-related cytokines. Neutrophilia in tissues decreases sensitivity to corticosteroids, but the mechanisms underlying the progression of neutrophilic CRS are unclear. Read More

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http://dx.doi.org/10.1038/s41385-019-0149-1DOI Listing
February 2019
7.374 Impact Factor

Clinical features of cats diagnosed with coccidioidomycosis in Arizona, 2004-2018.

J Feline Med Surg 2019 Feb 20:1098612X19829910. Epub 2019 Feb 20.

2 Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA.

Objectives: The goal of this study was to describe the clinical presentation, diagnosis and treatment of coccidioidomycosis in cats residing in a region endemic for Coccidioides species.

Methods: A retrospective review of records was performed at both primary and tertiary care veterinary practices in Tucson and Phoenix, Arizona. Data collected included signalment, clinical signs, physical examination findings, diagnostic test results, treatment and outcome. Read More

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http://dx.doi.org/10.1177/1098612X19829910DOI Listing
February 2019
2 Reads

Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis.

Front Immunol 2019 29;10:75. Epub 2019 Jan 29.

Department of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, United States.

Epidemiological evidence finds cigarette smoking is a common risk factor for a number of diseases, not only in the lung but also in other tissues, such as the gastrointestinal tract. While it is well-documented that smoking directly drives lung inflammatory disease, how it promotes disease in peripheral tissues is incompletely understood. In this study, we utilized a mouse model of short-term smoke exposure and found increased Th17 cells and neutrophilia in the lung as well as in the circulation. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361762PMC
January 2019
1 Read

Human exposure to mercury and its hematological effects: a systematic review.

Cad Saude Publica 2019 Feb 11;35(2):e00091618. Epub 2019 Feb 11.

Instituto de Estudos de Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

Mercury is a metal found in the environment from natural and anthropogenic sources. It is highly toxic to ecosystems and living beings. Most human exposures come from ingestion of contaminated seafood, outgassing from dental amalgam or occupational exposure (e. Read More

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http://dx.doi.org/10.1590/0102-311X00091618DOI Listing
February 2019
1 Read

Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis.

Clin Sci (Lond) 2019 Feb 18;133(4):551-564. Epub 2019 Feb 18.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia

Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and will become the third largest cause of death in the world by 2030. It is well established that an exaggerated inflammatory and oxidative stress response to cigarette smoke (CS) leads to, emphysema, small airway fibrosis, mucus hypersecretion, and progressive airflow limitation. Current treatments have limited efficacy in inhibiting chronic inflammation and consequently do not reverse the pathology that initiates and drives the long-term progression of disease. Read More

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http://dx.doi.org/10.1042/CS20180912DOI Listing
February 2019
3 Reads

Acanthocytosis and brain damage in area postrema and choroid plexus: Description of novel signs of Loxosceles apachea envenomation in rats.

PLoS One 2019 7;14(2):e0211689. Epub 2019 Feb 7.

Laboratorio de Biología Molecular y Bioquímica, Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, México.

Loxocelism is a neglected medical problem that depends on its severity, can cause a cutaneous or viscero-cutaneous syndrome. This syndrome is characterized by hemostatic effects and necrosis, and the severity of the loxoscelism depends on the amount of venom injected, the zone of inoculation, and the species. In the Chihuahuan desert, the most abundant species is L. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211689PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366775PMC
February 2019
1 Read

Severe asthma in children: therapeutic considerations.

Curr Opin Allergy Clin Immunol 2019 Apr;19(2):132-140

Department of Respiratory Paediatrics, Royal Brompton Hospital.

Purpose Of Review: Children with poor asthma control despite maximal maintenance therapy have problematic severe asthma (PSA). A step-wise approach including objective adherence monitoring and a detailed multidisciplinary team assessment to identify modifiable factors contributing to poor control is needed prior to considering therapy escalation. Pathophysiological phenotyping in those with true severe therapy-resistant asthma (STRA) and the current array of add-on therapies will be discussed. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000521DOI Listing
April 2019
1 Read

Proposal for a simple algorithm to differentiate adult-onset Still's disease with other fever of unknown origin causes: a longitudinal prospective study.

Clin Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine, Division of Rheumatology, Hacettepe University Medical School, Sihhiye, 06100, Ankara, Turkey.

Objective: To identify several clinical and/or laboratory parameters which can differentiate adult-onset Still's disease (AOSD) from other causes of fever of unknown origin (FUO) and create a clinician-friendly algorithm for this purpose.

Methods: FUO patients hospitalized between March 2015 and September 2017 were recruited prospectively. AOSD patients diagnosed between 2001 and 2017 in our department were analyzed. Read More

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http://dx.doi.org/10.1007/s10067-019-04455-yDOI Listing
February 2019
1 Read

Imbalance of NET and Alpha-1-Antitrypsin in Tuberculosis Patients Is Related With Hyper Inflammation and Severe Lung Tissue Damage.

Front Immunol 2018 10;9:3147. Epub 2019 Jan 10.

Molecular Mycobacteriology Laboratory, Medical School-Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Pulmonary tuberculosis (PTB) can lead to lung tissue damage (LTD) and compromise the pulmonary capacity of TB patients that evolve to severe PTB. The molecular mechanisms involved in LTD during anti-tuberculous treatment (ATT) remain poorly understood. We evaluated the role of neutrophil extracellular trap (NET) and the occurrence of LTD through chest radiographic images, the microbial load in sputum, and inflammatory serum profile (IL-12p40/p70, IL-8, IL-17A, IL-23, VEGF-A, MMP-1, and -8, galectin-3, citrunillated histone H3-cit-H3, alpha-1-antitrypsin-α1AT, C-reactive protein-CRP and albumin) in a cohort of 82 PTB patients before and after 60 days of ATT. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335334PMC
January 2019

Septic Shock Predisposed by an Underlying Chronic Neutrophilic Leukemia with an Atypical Presentation; A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):871-879. Epub 2018 Dec 20.

Department of Hematology & Oncology, University of Texas Medical Branch, Galveston, Texas, USA.

Background: Chronic neutrophilic leukemia (CNL) is an extremely rare myeloproliferative neoplasm (MPN). Due to the difficulty in its diagnosis, the diagnostic criterion was just recently revised in 2016. CNL is defined as: A clonal disorder with sustained primary neutrophilia, with normal neutrophil maturation, that does not meet other MPN criteria, as well as no identifiable mutations of the PDGFRA, PDGFRB or FGFR1 or PCM1-JAK2 genes, and, either, the presence of a CSF3R mutation, or if absent, the presence of sustained neutrophilia (> 3 months), splenomegaly and no other identifiable cause of reactive neutrophilia including the absence of a plasma cell neoplasm, or, if present, demonstration of myeloid cell clonality by cytogenetics. Read More

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http://dx.doi.org/10.1159/000495458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341362PMC
December 2018
3 Reads

Azithromycin and early allograft function after lung transplantation: A randomized, controlled trial.

J Heart Lung Transplant 2019 Mar 14;38(3):252-259. Epub 2018 Dec 14.

Lung Transplant Unit, Department of Chronic Diseases, Metabolism & Ageing. Electronic address:

Background: Chronic lung allograft dysfunction (CLAD) is the single most important factor limiting long-term survival after lung transplantation (LTx). Azithromycin has been shown to improve CLAD-free and long-term survival, yet the possible impact on early lung allograft function is unclear.

Methods: A prospective, randomized, double-blind, placebo-controlled trial of pre-transplant and prompt post-transplant azithromycin treatment was performed at the University Hospitals Leuven. Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.006DOI Listing
March 2019
1 Read

Spontaneous perforation of pyometra: A rare cause of acute abdomen and sepsis.

Turk J Surg 2018 Dec 1;34(4):342-345. Epub 2018 Dec 1.

Clinic of General Surgery, Health Science University Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey.

Pyometra, the accumulation of purulent material in the uterine cavity, is a rare gynecological condition whose etiology is impaired drainage of the uterine cavity. It is uncommon in premenopausal age and occurs mainly in older and postmenopausal women. Clinical signs of pyometra are vaginal discharge, postmenopausal bleeding, and lower abdominal pain. Read More

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http://dx.doi.org/10.5152/turkjsurg.2017.3203DOI Listing
December 2018
2 Reads

Gamma tocopherol effect on LPS-induced sputum neutrophilia is not modified by BMI or GSTM1 genotype.

J Allergy Clin Immunol 2019 Jan 17. Epub 2019 Jan 17.

Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC.

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http://dx.doi.org/10.1016/j.jaci.2018.12.1009DOI Listing
January 2019
4 Reads

Food protein-induced enterocolitis syndrome: guidelines summary and practice recommendations.

Med J Aust 2019 Feb 18;210(2):94-99. Epub 2019 Jan 18.

Children's Hospital at Westmead, Sydney, NSW.

Food protein-induced enterocolitis syndrome (FPIES) is a poorly understood non-IgE gastrointestinal-mediated food allergy that predominantly affects infants and young children. Cells of the innate immune system appear to be activated during an FPIES reaction. Acute FPIES typically presents between one and 4 hours after ingestion of the trigger food, with the principal symptom being profuse vomiting, and is often accompanied by pallor and lethargy. Read More

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http://dx.doi.org/10.5694/mja2.12071DOI Listing
February 2019
5 Reads

IL-17F, rather than IL-17A, underlies airway inflammation in a steroid insensitive toluene diisocyanate-induced asthma model.

Eur Respir J 2019 Jan 17. Epub 2019 Jan 17.

State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China

Steroid insensitivity constitutes the major problem for asthma management. Toluene diisocyanate (TDI) is one of the leading allergens of asthma that induces both Th2 and Th17 responses and is often associated with poor responsiveness to steroid treatment in the clinic. We sought to evaluate the effects of inhaled and systemic steroids on a TDI-induced asthma model and to find how IL-17A and IL-17F function in this model. Read More

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http://dx.doi.org/10.1183/13993003.01510-2018DOI Listing
January 2019
10 Reads

Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells.

Respir Res 2019 Jan 17;20(1):11. Epub 2019 Jan 17.

Department of Life Science and Technology, Tokyo Institute of Technology, 4259-B13 Nagatsuta-cho, Midori-ku, Yokohama, 226-8501, Japan.

Background: Adhesion G-protein coupled receptor F5 (ADGRF5) was recently identified as an essential regulator of pulmonary surfactant homeostasis in alveolar type II cells. We previously showed that in addition to abnormal surfactant accumulation, Adgrf5-deficient (Adgrf5) mice exhibit emphysema-like signs, suggesting a possible role for ADGRF5 in immune regulation. Here, we extended the phenotypic analysis of Adgrf5 mice to help understand its biological role in the lung, and especially in immune regulation. Read More

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http://dx.doi.org/10.1186/s12931-019-0973-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337809PMC
January 2019
2 Reads

Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma.

J Allergy Clin Immunol Pract 2019 Jan 14. Epub 2019 Jan 14.

Division of Allergy, Asthma, and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Va; Beirne Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Va; Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Va.

Background: Children with severe asthma have frequent exacerbations despite guidelines-based treatment with high-dose corticosteroids. The importance of refractory lung inflammation and infectious species as factors contributing to poorly controlled asthma in children is poorly understood.

Objective: To identify prevalent granulocyte patterns and potential pathogens as targets for revised treatment, 126 children with severe asthma underwent clinically indicated bronchoscopy. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.12.027DOI Listing
January 2019
4 Reads

Circulating innate immune markers and outcomes in treatment-naïve advanced non-small cell lung cancer patients.

Eur J Cancer 2019 Feb 14;108:88-96. Epub 2019 Jan 14.

Gustave Roussy Cancer Campus, F-94805, Villejuif, France; Laboratory of Immunomonitoring in Oncology, UMS 3655 CNRS/US 23 INSERM, Gustave Roussy Cancer Campus, F-94805, Villejuif, France; University Paris-Saclay, Faculty of Pharmacy, Chatenay-Malabry, F-92296, France. Electronic address:

Introduction: Innate immunity represents the first step of activation of the immune system and dictates the quality of adaptive immune responses. Studies have reported links between systemic inflammatory or innate immune markers and prognosis in patients with lung cancer. To our knowledge, the prospective and concomitant study of these systemic markers has never been performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183156
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http://dx.doi.org/10.1016/j.ejca.2018.12.017DOI Listing
February 2019
11 Reads

[Chronic myeloid leukemia presenting with marked eosinophilia].

Rinsho Ketsueki 2018 ;59(12):2594-2599

Department of Hematology, Tonan Hospital.

An 80-year-old female with fever, edema in the lower extremities, and marked eosinophilia was referred to our hospital. Based on the presence of the Philadelphia chromosome, she was diagnosed with chronic myeloid leukemia (CML). Although imatinib induced a complete cytogenetic response (CCyR), CML relapsed after 28 months of starting it. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2594/
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http://dx.doi.org/10.11406/rinketsu.59.2594DOI Listing
January 2018
4 Reads

Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still's disease.

Arthritis Res Ther 2019 Jan 7;21(1). Epub 2019 Jan 7.

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Shanghai, 200025, China.

Background: Adult-onset Still's disease (AOSD) is a systemic inflammatory disease characterized by neutrophilia and NLRP3 inflammasome and macrophage activation. We investigated the role of neutrophil extracellular traps (NETs) in the pathogenesis of AOSD, and explored the effect of NETs on activating NLRP3 inflammasome and proinflammatory macrophages.

Methods: The sera of 73 AOSD patients and 40 healthy controls were used to detect the level of cell-free DNA and NET-DNA complexes. Read More

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http://dx.doi.org/10.1186/s13075-018-1800-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323819PMC
January 2019
8 Reads

Clinicopathological findings in 41 dogs (2008-2018) naturally infected with Ehrlichia ewingii.

J Vet Intern Med 2019 Jan 2. Epub 2019 Jan 2.

Vector Borne Disease Diagnostic Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

Background: Ehrlichia ewingii is the most seroprevalent Ehrlichia-infecting dogs in the southern and mid-western United States. Fever, lameness, and polyarthritis are commonly reported findings in dogs naturally infected with E. ewingii. Read More

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http://dx.doi.org/10.1111/jvim.15354DOI Listing
January 2019
2 Reads

Rosai-Dorfman disease as a rare cause of cervical lymphadenopathy - case report and literature review.

Cent Eur J Immunol 2018 30;43(3):341-345. Epub 2018 Oct 30.

Department of Paediatrics, Haematology, and Oncology, University Clinical Centre in Gdansk, Poland.

Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, benign clinical entity of unknown cause. RDD is characterised by the overproduction and accumulation of histiocytes, primarily in the lymph nodes, although it may affect every organ and system. It predominantly affects children and young adults. Read More

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http://dx.doi.org/10.5114/ceji.2018.80055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305605PMC
October 2018
1 Read

In vivo toxicological evaluation of polymer brush engineered nanoceria: impact of brush charge.

Nanotoxicology 2018 Dec 22:1-21. Epub 2018 Dec 22.

c 3 Laboratory of Nanobiotechnology, Department of Genetics and Morphology , Institute of Biological Sciences, University of Brasília , Brasília DF , Brazil.

Nanoceria has a broad variety of industrial and pharmacological applications due to its antioxidant activity. Nanoceria can be modified by surface coating with polyelectrolyte brushes. Brushes can increase the surface charge of nanoceria, providing greater aqueous stability while reducing agglomeration. Read More

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http://dx.doi.org/10.1080/17435390.2018.1543469DOI Listing
December 2018
3 Reads

Repeated clodronate-liposome treatment results in neutrophilia and is not effective in limiting obesity-linked metabolic impairments.

Am J Physiol Endocrinol Metab 2019 Mar 21;316(3):E358-E372. Epub 2018 Dec 21.

Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina , Columbia, South Carolina.

Depletion of macrophages is thought to be a therapeutic option for obesity-induced inflammation and metabolic dysfunction. However, whether the therapeutic effect is a direct result of reduced macrophage-derived inflammation or secondary to decreases in fat mass is controversial, as macrophage depletion has been shown to disrupt energy homeostasis. This study was designed to determine if macrophage depletion via clodronate-liposome (CLD) treatment could serve as an effective intervention to reduce obesity-driven inflammatory and metabolic impairments independent of changes in energy intake. Read More

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https://www.physiology.org/doi/10.1152/ajpendo.00438.2018
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http://dx.doi.org/10.1152/ajpendo.00438.2018DOI Listing
March 2019
10 Reads

Ibuprofen, a Potential Cause of Acute Hemorrhagic Gastritis in Children - A Case Report.

J Crit Care Med (Targu Mures) 2018 Oct 1;4(4):143-146. Epub 2018 Oct 1.

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania.

Introduction: Upper gastrointestinal bleeding is an uncommon but possible life-threatening entity in children, frequently caused by erosive gastritis. Non-steroidal anti-inflammatory drugs are one of the most common class of drugs which can cause gastrointestinal complications, including hemorrhagic gastritis.

Case Report: The case of a 6-year-old male, admitted for hematemesis, abdominal pain and loss of appetite. Read More

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http://content.sciendo.com/view/journals/jccm/4/4/article-p1
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http://dx.doi.org/10.2478/jccm-2018-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296277PMC
October 2018
13 Reads

Sweet Syndrome in Pediatrics. A case report.

Rev Chil Pediatr 2018 Aug;89(4):511-515

Servicio de Anatomía Patológica, Hospital Roberto del Río, Chile.

Introduction: Sweet's syndrome is a very rare dermatosis in pediatrics, of unknown pathogenesis, clinically characterized by fever, neutrophilia, raised and painful plaques on the skin of the face, neck, and limbs, and histologically by dermal infiltration of neutrophils.

Objective: To present a clinical case of Sweet Syndrome in a pediatric patient.

Clinical Case: 3-years-old female child, with history of complex chromosomopathy 46XX add(8), with a 7-day history of plaques and blisters on the back and later also on the limbs, associated with high fever, without response to antibiotic treatment pres cribed due to suspicion of bullous impetigo. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000603DOI Listing
August 2018
11 Reads

Benign pneumatosis intestinalis with massive portomesenteric venous gas in a very old man. A case report.

G Chir 2018 Nov-Dec;39(6):391-394

Introduction: Pneumatosis intestinalis (PI) is described as the presence of air within bowel wall. PI aetiology is various: it can be associated with non-urgent or life-threatening conditions. Clinical management is based on physical examination, blood tests and radiology, in particular abdominal CT. Read More

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December 2018
1 Read

Teaching an Old Intensivist Neutrophil Tricks: Using Alveolar Neutrophilia to Diagnose Ventilator-Associated Pneumonia.

Am J Respir Crit Care Med 2018 Dec 13. Epub 2018 Dec 13.

Yale University, Pulmonary and Critical Care Medicine, New Haven, Connecticut, United States ;

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http://dx.doi.org/10.1164/rccm.201811-2163EDDOI Listing
December 2018

Zinc toxicosis in a dog secondary to prolonged zinc oxide ingestion.

Authors:
Jia Wen Siow

Open Vet J 2018 25;8(4):458-462. Epub 2018 Nov 25.

AEC Adelaide, 102 Magill Road, Norwood South Australia 5067, Australia.

Zinc toxicosis is commonly associated with ingestion of metallic zinc objects. This report documents an uncommon presentation of zinc toxicosis, secondary to prolonged ingestion of a zinc oxide cream. A 5. Read More

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http://dx.doi.org/10.4314/ovj.v8i4.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258521PMC
November 2018

In-DANBIRT Molecular Imaging of Inflammatory Cells in Atherosclerosis.

Contrast Media Mol Imaging 2018 13;2018:6508724. Epub 2018 Nov 13.

Radiopharmaceutical Sciences, University of New Mexico (UNM), Albuquerque, NM, USA.

Atherosclerosis-related morbidity and mortality remain a global concern. Atherosclerotic disease follows a slow and silent progression, and the transition from early-stage lesions to vulnerable plaques remains difficult to diagnose. Inflammation is a key component of the development of atherosclerotic plaque and consequent life-threatening complications. Read More

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http://dx.doi.org/10.1155/2018/6508724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257909PMC
November 2018
2 Reads

Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation.

Front Immunol 2018 26;9:2718. Epub 2018 Nov 26.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environmental factors and characterized by airflow obstruction, wheezing, eosinophilia, and neutrophilia of lungs and sputum. Similar to other proinflammatory cytokines, IL-6 is elevated in asthma and plays an active role in this disease. However, the exact molecular mechanism of IL-6 involvement in the pathogenesis of asthma remains largely unknown and the major cellular source of pathogenic IL-6 has not been defined. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276801PMC
November 2018
5 Reads

Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice.

Toxicol Appl Pharmacol 2019 Feb 5;364:29-44. Epub 2018 Dec 5.

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

Nrf2 is essential to antioxidant response element (ARE)-mediated host defense. Sulforaphane (SFN) is a phytochemical antioxidant known to affect multiple cellular targets including Nrf2-ARE pathway in chemoprevention. However, the role of SFN in non-malignant airway disorders remain unclear. Read More

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http://dx.doi.org/10.1016/j.taap.2018.12.004DOI Listing
February 2019
4 Reads

Schnitzler's syndrome: A female elderly case presenting intractable non-pruritic febrile urticarial rush.

Asian Pac J Allergy Immunol 2018 Dec 9. Epub 2018 Dec 9.

Graduate School of Medical Sciences, Department of Dermatology, Kyushu University, Fukuoka, Japan.

Schnitzler's syndrome is an acquired autoinflammatory disease characterized by chronic urticarial rash and monoclonal gammopathy (predominantly IgM type). A 75-year-old Japanese woman complained of high fever and non-pruritic urticarial rash appearing almost every day for 3 years. Her abnormal laboratory data included leukocytosis and neutrophilia with elevated erythrocyte sedimentation rate and C-reactive protein level. Read More

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http://dx.doi.org/10.12932/AP-150818-0394DOI Listing
December 2018
9 Reads

Novel roles for nasal epithelium in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Rhinology 2018 Dec 1. Epub 2018 Dec 1.

Otorhinolaryngology, Academic Medical Center, Amsterdam, the Netherlands.

Background: Airway epithelial cells have a well-accepted role in the regulation of local inflammatory processes in allergic and innate defence responses. However, their role the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) is unclear. The objective was to investigate whether potential differences in the mRNA expression profile of nasal epithelia from healthy individuals and from CRSwNP patients would shed new light on disease mechanisms. Read More

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http://dx.doi.org/10.4193/Rhin18.128DOI Listing
December 2018
3 Reads