496 results match your criteria Neutropenic Enterocolitis


Appendiceal perforation due to biliary stent migration in a neutropenic patient with lung cancer receiving chemotherapy: A case report.

Mol Clin Oncol 2021 Jul 17;15(1):136. Epub 2021 May 17.

Department of Gastrointestinal Surgery, Kanta-Häme Central Hospital, Hämeenlinna 13530, Finland.

The use of biliary stents has become a common and usually safe procedure. However, the migration of biliary stents is an uncommon but well-recognized event after endoscopic retrograde cholangiopancreatography. The migration of plastic stents usually does not result in complications and are spontaneously eliminated from the gastro-intestinal tract. Read More

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Neutropenic enterocolitis-induced sepsis and disseminated intravascular coagulation after chemotherapy: a case report.

BMC Womens Health 2021 05 3;21(1):187. Epub 2021 May 3.

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Enyacho 89-1, Izumo, Shimane, 6938501, Japan.

Background: Neutropenic enterocolitis (NE) is a potentially life-threatening disease that primarily occurs in cancer patients treated with chemotherapy. NE has substantial morbidity and mortality, and its incidence has increased with the widespread use of chemotherapeutic agents such as taxanes, gemcitabine, and leucovorin in patients with lung, breast, gastric, and ovarian cancers. Sometimes NE can be a possible cause of death. Read More

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Good functional outcome following severe neutropenic enterocolitis and perforation in a 48-year-old woman undergoing chemotherapy for breast cancer.

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Anaesthesia, Yeovil District Hospital, Yeovil, UK.

Neutropenic enterocolitis (NEC) is a life-threatening bowel condition, usually resulting from chemotherapy, with a mortality rate thought to be as high as 50%. Markers of poor prognosis include gastrointestinal perforation and bowel wall thickness radiologically detected to be greater than 10 mm. NEC is associated with severe neutropenia and predominantly affects the large bowel; however, we present a case of severe NEC with oesophageal perforation requiring transfer to a specialist upper gastrointestinal unit for corrective stenting. Read More

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Neutropenic Enterocolitis Complicating Induction Chemotherapy in an Acute Myeloid Leukemia Patient.

Cureus 2021 Jan 31;13(1):e13029. Epub 2021 Jan 31.

Internal Medicine, Baystate Medical Center, Springfield, USA.

Neutropenic enterocolitis is a rare inflammatory condition of the ileocecum. Clinicians should be aware of neutropenic enterocolitis in neutropenic patients with hematologic malignancies undergoing chemotherapy as it portends a poor prognosis if not diagnosed early in its course. We report a patient diagnosed with neutropenic enterocolitis within one week of receiving induction chemotherapy for acute myeloid leukemia. Read More

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January 2021

COVID-19-associated pancytopenia and typhlitis.

Am J Emerg Med 2021 Jan 4. Epub 2021 Jan 4.

Department of Infectious Disease, School of Medicine, Pamukkale University, 20100 Denizli, Turkey.

Neutropenic enterocolitis is also known as typhlitis, is characterized by severe inflammation in the bowel loops. It is often seen in immunosuppressed patients, and it has high morbidity and mortality. Although the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system and causes COVID-19 (Coronavirus Disease 2019), it may affect hematopoietic and gastrointestinal systems. Read More

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January 2021

Paclitaxel-Induced Bowel Perforation: A Rare Cause of Acute Abdomen.

Case Rep Gastroenterol 2020 Sep-Dec;14(3):687-694. Epub 2020 Dec 14.

Division of Gastroenterology, BronxCare Hospital Center, a Clinical Affiliate of Mount Sinai Health Systems and Academic Affiliate of Icahn School of Medicine, Bronx, New York, New York, USA.

Paclitaxel, a chemotherapeutic agent, is routinely administered for the treatment of various solid organ malignancies. In rare instances, patients receiving infusions of paclitaxel may present with signs of an acute abdomen. Ischemia and necrosis of the bowel wall from chemotherapy-induced neutropenia and direct toxic effects of the drug have been implicated as the cause. Read More

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December 2020

Candida parapsilosis neutropenic enterocolitis.

Int J Infect Dis 2021 Mar 9;104:269-270. Epub 2021 Jan 9.

Division of Hematology, Shonan Kamakura General Hospital, Japan.

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Neutropenic Enterocolitis Disclosing an Underlying Cyclic Neutropenia.

Case Rep Pediatr 2020 1;2020:8858764. Epub 2020 Dec 1.

Hematology Department, University Hospital Mohamed VI, Faculty of Medicine, Cadi Ayyad University, Marrakech, Morocco.

Neutropenic enterocolitis is a syndrome characterized by fever and abdominal pain in a neutropenic patient. It is often reported in children treated for leukemia and rarely reported in patients with other diseases. Herein, we report the case of a 9-year-old patient with a medical history of recurrent fever and mouth ulcers since the age of 4, who presented with neutropenic enterocolitis complicated with intestinal perforation which all leaded to disclose cyclic neutropenia. Read More

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December 2020

Eimeria ninakohlyakimovae casts NOX-independent NETosis and induces enhanced IL-12, TNF-α, IL-6, CCL2 and iNOS gene transcription in caprine PMN.

Exp Parasitol 2021 Jan 12;220:108034. Epub 2020 Nov 12.

Parasitology Unit, Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Las Palmas, Spain. Electronic address:

Eimeria ninakohlyakimovae represents a highly pathogenic coccidian parasite causing severe haemorrhagic typhlocolitis in goat kids worldwide. NETosis was recently described as an efficient defense mechanism of polymorphonuclear neutrophils (PMN) acting against different parasites in vitro and in vivo. In vitro interactions of caprine PMN with parasitic stages of E. Read More

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January 2021

Obstructed ileocaecal tuberculosis with splenic tuberculosis and solid pseudopapillary tumour of tail of pancreas in an immunocompetent woman.

BMJ Case Rep 2020 Sep 2;13(9). Epub 2020 Sep 2.

General Surgery, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

A 22-year-old young woman presented with fever, lower abdominal pain and vomiting for 20 days. She had persistent fever and abdominal pain. Fever panel was negative. Read More

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September 2020

Neutropenic enterocolitis in pediatric leukemia patients treated with intensive chemotherapy in Upper Egypt.

Pediatr Investig 2020 Mar 17;4(1):5-10. Epub 2020 Mar 17.

Department of Pediatric Oncology South Egypt Cancer Institute Assiut University Assiut Egypt.

Importance: In low resource countries, there has been scarcity of research on the risk factors associated with neutropenic enterocolitis, a serious complication that commonly develops during treatment of cancer patients.

Objective: To identify the pattern of intestinal complications in pediatric leukemia patients treated with intensive chemotherapy, including those with neutropenic enterocolitis; to assess the outcome; and to evaluate the risk factors associated with the mortality in these patients.

Methods: During the period from June 2015 to December 2016, a prospective study was carried out on pediatric patients diagnosed with acute leukemia who received induction/or re-induction phases of chemotherapy at South Egypt Cancer Institute. Read More

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Neutropenic Enterocolitis and Rapid Spontaneous Resolution of Portal Venous Gas: A Non-Respiratory Manifestation of COVID-19.

Cureus 2020 Jul 28;12(7):e9445. Epub 2020 Jul 28.

Critical Care Medicine, Guthrie Robert Packer Hospital, Sayre, USA.

The COVID-19 pandemic is affecting millions across the globe. The population of immunosuppressed individuals are at greatest risk of morbidity and mortality. Data on COVID-19 induced illness in the immunocompromised host are sparse. Read More

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Neutropenic Enterocolitis Secondary to Sulfasalazine in a Woman With Psoriatic Arthritis.

Cureus 2020 Jun 12;12(6):e8576. Epub 2020 Jun 12.

Hematology and Oncology, Staten Island University Hospital, Staten Island, USA.

Neutropenic enterocolitis (NE) also known as typhlitis is a serious condition that has been described in immunosuppressed hosts including patients with leukemia, HIV and in patients on chemotherapy. We present the first case of female on sulfasalazine for psoriatic arthritis, otherwise healthy, who was diagnosed with NE involving the cecum and rectum. This adds up to the cases of NE diagnosed in nononcologic conditions. Read More

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Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer.

Case Rep Oncol Med 2020 16;2020:7231358. Epub 2020 Jun 16.

Department of Breast and Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. Read More

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Neutropenic Enterocolitis in the Treatment of Solid Tumors: A Case Report and Review of the Literature.

Case Rep Oncol 2020 Jan-Apr;13(1):442-448. Epub 2020 Apr 22.

Department of Oncology, Fondazione Poliambulanza, Brescia, Italy.

Neutropenic enterocolitis is a clinical condition characterized by inflammation of the colic mucosa, usually the caecum, associated with bowel wall thickening in patients with compromised immune system due to chemotherapy treatments. It can occur as well in other clinical conditions that lead to immunosuppression. Clinically, patients present with abdominal pain, fever, and neutropenia on blood tests. Read More

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Hepatic Portal Venous Gas: An Ill Omen or a Misleading Sign.

Surg J (N Y) 2020 Jan 3;6(1):e37-e41. Epub 2020 Mar 3.

Department of Internal Medicine and Medical Gastroenterology, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.

Hepatic portal venous gas (HPVG), a rare radiological finding, is historically considered an ominous sign with 100% mortality rates. The dictum that HPVG warrants surgical intervention is challenged in the recent literature. This is because of the identification of various causes of HVPG other than bowel gangrene. Read More

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January 2020

Typhlitis Associated With Natural . Infection in Cats.

Vet Pathol 2020 03 27;57(2):266-271. Epub 2020 Feb 27.

Department of Biomedical Sciences, Ross University School of Veterinary Medicine, St. Kitts, West Indies.

. infections can cause typhlitis or typhlocolitis in many species, but there are no published studies about its pathology in cats. . Read More

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Chemotherapy-associated neutropenic enterocolitis of the transverse colon post right hemicolectomy.

Oxf Med Case Reports 2019 Nov 19;2019(11):omz140. Epub 2019 Dec 19.

Metropolitan Group Hospitals General Surgery Residency, Advocate Illinois Masonic Hospital, University of Illinois, Chicago, IL, USA.

Neutropenic enterocolitis (NE) is a life-threatening infection of the immunocompromised. NE ubiquitously affects the cecum, often with involvement of the ascending colon and ileum. Classically, NE is associated with high mortality leading to the frequent use of aggressive treatment strategies including surgery. Read More

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November 2019

Neutropenic Enterocolitis: Clinical Features and Outcomes.

Dis Colon Rectum 2020 03;63(3):381-388

Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Patients undergoing chemotherapy are at risk for mucosal injury and neutropenia, which facilitate colonic mucosal invasion by the bowel flora and subsequent neutropenic enterocolitis, which has a poor prognosis.

Objective: This study aimed to assess the clinical features and outcomes of neutropenic enterocolitis in patients at a comprehensive cancer center.

Design: This is a retrospective cohort study. Read More

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Pharmacokinetics of doxorubicin following concomitant intravenous administration of olaratumab (IMC-3G3) to patients with advanced soft tissue sarcoma.

Cancer Med 2020 02 10;9(3):882-893. Epub 2019 Dec 10.

Eli Lilly and Company, Indianapolis, IN, USA.

Background: Olaratumab, a fully human monoclonal antibody, selectively binds to human platelet-derived growth factor receptor alpha and blocks ligand binding. This study assessed the effect of olaratumab on the pharmacokinetics (PK) of doxorubicin and the safety of olaratumab alone and in combination with doxorubicin.

Methods: This open-label randomized phase 1 trial enrolled 49 patients ages 27 to 83 with metastatic or locally advanced soft tissue sarcoma (STS). Read More

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February 2020

Neutropenic enterocolitis: A clinico-pathological review.

World J Gastrointest Pathophysiol 2019 Oct;10(3):36-41

Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, United States.

Neutropenic enterocolitis (NE) is a predominantly cecum-based disease with high mortality seen in patients post chemotherapy. The pathogenesis of NE is poorly understood and probably multifactorial involving mucosal injury, neutropenia, and impaired host defense to intestinal organisms. The clinical presentation is characterized as ileocolonic inflammation and bowel wall thickening in patients with neutropenia, fever, and abdominal pain. Read More

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October 2019

Fatal neutropenic enterocolitis associated with docetaxel use: A review of cases reported to the United States Food and Drug Administration Adverse Event Reporting System.

J Oncol Pharm Pract 2020 Jun 8;26(4):923-928. Epub 2019 Oct 8.

Division of Pharmacovigilance, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.

Docetaxel is a microtubule inhibitor indicated for the treatment of multiple cancers as a single agent or in combination with other antineoplastics. The U.S. Read More

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Adult Necrotising Enterocolitis in a Breast Cancer Patient after First Cycle of Adjuvant Chemotherapy.

J Coll Physicians Surg Pak 2019 Oct;29(10):1006-1008

Department of Surgery, Islamabad Medical Complex, Nescom, Islamabad, Pakistan.

Chemotherapy-induced diarrhea has become a worrisome problem for the patients as well as the treating surgeons and oncologists because patient outcome is significantly affected. Necrotising enterocolitis is a rare disease in adults. It is now termed as neutropenic enterocolitis in adults, because it is seen more often as a complication of aggressive systemic chemotherapy. Read More

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October 2019

Intussusception caused by typhlitis: a rare complication in a patient with acute lymphoblastic leukemia after chemotherapy.

Int J Colorectal Dis 2019 Oct 11;34(10):1815-1818. Epub 2019 Sep 11.

Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Introduction: Intussusception, which is common in pediatric patients but rare in adults with leukemia, usually presents with an intralumenal lesion as a lead point in adults.

Case Report: We herein report the case of a 38-year-old female who developed right lower quadrant abdominal pain and fever on day 16 of chemotherapy. Abdominal computed tomography showed ileocecal intussusception. Read More

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October 2019

Does a neutropenic diet reduce adverse outcomes in patients undergoing chemotherapy?

Eur J Cancer Care (Engl) 2020 Jan 23;29(1):e13155. Epub 2019 Aug 23.

Nutrition and Dietetics, College of Nursing and Health Science, Flinders University, Adelaide, SA, Australia.

Objective: This study aimed to compare clinical outcomes of chemotherapy patients who received either a neutropenic diet (ND) or liberalised diet (LD) and to investigate associations between ND and infectious outcomes.

Methods: A retrospective case note audit of patients admitted to Flinders Medical Centre from 2013 to 2017 was conducted. Patients were eligible if they were aged 18 years and above, received chemotherapy and were neutropenic during admission. Read More

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January 2020

Fatal parasite-induced enteritis and typhlocolitis in horses in Southern Brazil.

Rev Bras Parasitol Vet 2019 Aug 1;28(3):443-450. Epub 2019 Aug 1.

Setor de Patologia Veterinária, Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brasil.

Diseases related to the alimentary system are the main cause of death in horses. This retrospective study aimed to describe the pathological findings of fatal parasite-induced enteritis and typhlocolitis caused by cyathostominae, Eimeria leuckarti, Balantidium coli, and Strongyloides westeri in horses. The records of parasite-induced intestinal lesions in horses necropsied in Southern Brazil between 2005 and 2017 were reviewed. Read More

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[Antimicrobial therapy in cancer patients and hematopoietic stem cell transplantation receptors].

Rev Chilena Infectol 2019 Apr;36(2):167-178

Servicio de Farmacia Clínica, Hospital Exequiel González Cortés, Santiago, Chile.

This manuscript includes the antiinfective therapeutic resources for immunocompromised patients under chemotherapy by cancer or hematopoietic stem cells transplant (HSCT) receptors. The document presents the antimicrobial therapy indicated in the most prevalent clinical situations in this population and the primary and alternative therapy for some specific microorganisms. The clinical situations included in the analysis are: febrile neutropenia without focus, sepsis, infections of the central nervous system, pneumonia, skin and soft tissue infections, neutropenic enterocolitis and urinary tract infection. Read More

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Impact of inflammation on brain subcellular energetics in anesthetized rats.

BMC Neurosci 2019 07 15;20(1):34. Epub 2019 Jul 15.

Department of Anesthesiology, University of Virginia School of Medicine, P.O. Box 800710, Charlottesville, VA, 22908-0710, USA.

Background: Emerging data suggests that volatile anesthetic agents may have organ protection properties in the setting of critical illness. The purpose of this study was to better understand the effect of inflammation on cerebral subcellular energetics in animals exposed to two different anesthetic agents-a GABA agonist (propofol) and a volatile agent (isoflurane).

Results: Forty-eight Sprague-Dawley rats were anesthetized with isoflurane or propofol. Read More

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