345 results match your criteria Neutropenic Enterocolitis


Factors associated with emergent colectomy in patients with neutropenic enterocolitis.

Langenbecks Arch Surg 2019 Apr 5. Epub 2019 Apr 5.

Department of Colorectal Surgery, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Vasco de Quiroga, 15, Sección XVI, Tlalpan, 14080, Mexico City, Mexico.

Purpose: Neutropenic enterocolitis (NEC) is a severe complication of neutropenia. NEC is characterized by segmental ulceration, intramural inflammation, and necrosis. Factors present in patients who underwent colectomy have never been studied. Read More

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http://dx.doi.org/10.1007/s00423-019-01781-2DOI Listing
April 2019
2 Reads
2.160 Impact Factor

Pathology of Gastrointestinal and Liver Complications of Hematopoietic Stem Cell Transplantation.

Arch Pathol Lab Med 2019 Mar 6. Epub 2019 Mar 6.

Faculté de médecine, département de biologie moléculaire, de biochimie médicale et de pathologie, Université Laval, Hôpital du Saint-Sacrement - CHU de Québec, Québec, Québec, Canada (Dr Mourad); the Department of Pathology, McGill University and McGill University Health Center, Montreal, Quebec, Canada (Drs Michel and Marcus).

Context.—: Despite advances in therapeutic and preventive measures, hematopoietic stem cell transplant recipients remain at risk of a variety of gastrointestinal and liver complications.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0282-RADOI Listing
March 2019
3 Reads

Neutropenic Enterocolitis in Critically Ill Patients: Spectrum of the Disease and Risk of Invasive Fungal Disease.

Crit Care Med 2019 May;47(5):668-676

Medical Intensive Care Unit, Hospital Saint Louis, Assistance Publique-Hôpitaux de Paris, France.

Objectives: Neutropenic enterocolitis occurs in about 5.3% of patients hospitalized for hematologic malignancies receiving chemotherapy. Data from critically ill patients with neutropenic enterocolitis are scarce. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003687DOI Listing
May 2019
3 Reads

Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication.

Indian J Cancer 2018 Jul-Sep;55(3):304-305

Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropenic enterocolitis to which he succumbed. Read More

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http://dx.doi.org/10.4103/ijc.IJC_260_18DOI Listing
January 2019
4 Reads

Neutropenic enterocolitis in patients with FLT3 mutated acute myeloid leukemia undergoing induction chemotherapy with midostaurin.

Int J Hematol 2019 Mar 3;109(3):351-355. Epub 2018 Dec 3.

Department of Hematology and Oncology, Marshall University, 1400 Hal Greer Blvd, Huntington, WV, 25701, USA.

Neutropenic enterocolitis mostly affects patients with acute myeloid leukemia (AML) who get treated with intensive chemotherapy which is associated with prolonged neutropenia; its pathogenesis is not well understood and the main factors in this life-threatening condition appear to be neutropenia, mucosal injury and a weakened immune system as a consequence of intensive chemotherapeutic agents. Midostaurin in combination with chemotherapy became the standard of care for FLT3 mutant AML since its approval by the United States Food and Drug Administration (FDA) in April 2017. Anecdotally in our institution, we noticed the common occurrence of neutropenic colitis in three out of three patients who were treated with midostaurin as part of induction chemotherapy for AML. Read More

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http://dx.doi.org/10.1007/s12185-018-2558-4DOI Listing
March 2019
4 Reads

A randomized placebo-controlled phase II study of clarithromycin or placebo combined with VCD induction therapy prior to high-dose melphalan with stem cell support in patients with newly diagnosed multiple myeloma.

Exp Hematol Oncol 2018 13;7:18. Epub 2018 Aug 13.

8Department of Hematology, Odense University Hospital, 5000 Odense C, Denmark.

Background: The objective of this randomized placebo-controlled study was to investigate the efficacy and safety of clarithromycin in combination with bortezomib-cyclophosphamide-dexamethasone (VCD) in patients with newly diagnosed multiple myeloma eligible for high-dose therapy.

Methods: Patients were randomized to receive tablet clarithromycin 500 mg or matching placebo tablet twice daily during the first 3 cycles of VCD induction therapy. Primary endpoint was to compare the rate of very good partial response (VGPR) or better response after three cycles of VCD combined with clarithromycin or placebo. Read More

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http://dx.doi.org/10.1186/s40164-018-0110-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090810PMC
August 2018
12 Reads

Fatal Neutropenic Enterocolitis Caused by Stenotrophomonas maltophilia: A Rare and Underrecognized Entity.

Intern Med 2018 Dec 10;57(24):3667-3671. Epub 2018 Aug 10.

Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan.

Although Stenotrophomonas maltophilia causes substantial morbidity and mortality in immunocompromised patients, it has not been described as a causal pathogen of neutropenic enterocolitis (NEC). We describe the first case of histologically-confirmed NEC caused by S. maltophilia accompanied by bacteremia and pneumonia after salvage chemotherapy for acute myeloid leukemia relapse following a second hematopoietic stem cell transplantation. Read More

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http://dx.doi.org/10.2169/internalmedicine.1227-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355424PMC
December 2018
2 Reads

Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants.

Case Rep Transplant 2018 8;2018:3264921. Epub 2018 May 8.

UCLA Mattel Children's Hospital, Pediatric Heart Transplant Program, 200 UCLA Medical Plaza Suite 330, Los Angeles, CA 90024, USA.

Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the first published case of NE occurring in the setting of pediatric heart transplant. This patient was diagnosed several months after pediatric heart transplant, with radiographs showing evidence of pneumatosis intestinalis. Read More

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http://dx.doi.org/10.1155/2018/3264921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964482PMC
May 2018
11 Reads

The prognostic impact of abdominal surgery in cancer patients with neutropenic enterocolitis: a systematic review and meta-analysis, on behalf the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH).

Ann Intensive Care 2018 Apr 19;8(1):47. Epub 2018 Apr 19.

GRRR-OH (Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie), Paris, France.

Neutropenic enterocolitis (NE) is a diagnostic and therapeutic challenge associated with high mortality rates, with controversial opinions on its optimal management. Physicians are usually reluctant to select surgery as the first-choice treatment, concerns being raised regarding the potential risks associated with abdominal surgery during neutropenia. Nevertheless, no published studies comforted this idea, literature is scarce and surgery has never been compared to medical treatment. Read More

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http://dx.doi.org/10.1186/s13613-018-0394-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908777PMC
April 2018
9 Reads

Acute myositis: an unusual and severe side effect of docetaxel: a case report and literature review.

Anticancer Drugs 2018 06;29(5):477-481

Departments of Medical Oncology.

Docetaxel is an antimicrotubules cytotoxic agent prescribed widely by medical oncologists in multiple tumor types (breast, lung, prostate, stomach, head, and neck). However, the side effects of docetaxel are numerous (cytopenia, peripheral edema, myalgia, arthralgia, alopecia, and sensitive neuropathy) and recent concerns have been raised about neutropenic enterocolitis in France. Here, we report the case of a 57-year-old patient with metastatic prostatic cancer, who developed a severe myositis and fasciitis grade IV 1 week after his second docetaxel infusion. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000620DOI Listing
June 2018
9 Reads

Mucosal Biopsy After Bone Marrow Transplantation.

Surg Pathol Clin 2017 Dec 27;10(4):909-930. Epub 2017 Sep 27.

Department of Pathology, University of Michigan, 5231F, 1301 Catherine Street, Ann Arbor, MI 48109-5602, USA.

Gastrointestinal mucosal biopsies in the hematopoietic stem cell transplantation setting are challenging because histologic features of graft-versus-host disease (GVHD), which is treated by increasing immunosuppression, overlap with those of other conditions, such as infection, which can get worse with GVHD treatment. More than one condition can occur at the same time. It is important to understand the histologic features of GVHD, drug toxicity, infection, and clinical factors surrounding patients, including timing of biopsy in relation to transplantation, medication history, and laboratory data. Read More

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http://dx.doi.org/10.1016/j.path.2017.07.006DOI Listing
December 2017
8 Reads

A fresh look at polymicrobial bloodstream infection in cancer patients.

PLoS One 2017 24;12(10):e0185768. Epub 2017 Oct 24.

Department of Infectious Diseases, Hospital Universitari de Bellvitge, IDIBELL (Institut d´Investigació Biomèdica de Bellvitge), University of Barcelona, Barcelona, Spain.

Objectives: To assess the current incidence, clinical features, risk factors, aetiology, antimicrobial resistance and outcomes of polymicrobial bloodstream infection (PBSI) in patients with cancer.

Methods: All prospectively collected episodes of PBSI in hospitalised patients were compared with episodes of monomicrobial bloodstream infection (MBSI) between 2006 and 2015.

Results: We identified 194 (10. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185768PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655483PMC
November 2017
4 Reads

Daunorubicin 90 mg/m in Acute Myeloid Leukemia Induction: Increased Toxicity in Young Patients.

Clin Lymphoma Myeloma Leuk 2017 08 21;17(8):527-531. Epub 2017 Jun 21.

Hematology Service, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: The combination of an anthracycline and cytosine arabinoside has been the standard induction therapy for acute myeloid leukemia for more than 3 decades. The clinical benefit of intensification of the daunorubicin dose to 90 mg/m has been supported by randomized trials. Based on these promising results, in 2010 we changed our induction protocol of acute myeloid leukemia, increasing the dose of daunorubicin. Read More

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http://dx.doi.org/10.1016/j.clml.2017.06.018DOI Listing
August 2017
4 Reads

Neutropenic enterocolitis (typhlitis) in a pediatric renal transplant patient. A case report and review of the literature.

Pediatr Transplant 2017 Sep 30;21(6). Epub 2017 Jun 30.

Division of Pediatric Nephrology, Department of Pediatrics, Duke University Health System, Durham, NC, USA.

NE (typhlitis) is a potentially life-threatening disease process characterized by bowel wall edema, ulceration, and hemorrhage in an immunosuppressed patient. We report a 15-year-old boy status post deceased donor renal transplantation who presented with fever, abdominal pain, and diarrhea. Laboratory studies revealed neutropenia 5 days prior to admission, and abdominal computed tomography revealed bowel wall thickening in the cecum consistent with NE. Read More

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http://doi.wiley.com/10.1111/petr.13022
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http://dx.doi.org/10.1111/petr.13022DOI Listing
September 2017
7 Reads

Moxifloxacin versus levofloxacin or ciprofloxacin prophylaxis in acute myeloid leukemia patients receiving chemotherapy.

Support Care Cancer 2017 12 28;25(12):3715-3721. Epub 2017 Jun 28.

College of Pharmacy and Health Sciences, Butler University, 4600 Sunset Ave, Indianapolis, IN, 46208, USA.

Purpose: Patients receiving intensive chemotherapy regimens are at high risk for infectious complications due to prolonged neutropenia and hospital stay. Fluoroquinolone antibiotics, mainly levofloxacin and ciprofloxacin, are the mainstay of prophylactic therapy for these patients. There is limited data regarding the utilization of other quinolone antibiotics including moxifloxacin in this setting. Read More

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http://dx.doi.org/10.1007/s00520-017-3797-2DOI Listing
December 2017
4 Reads

spp. and colonization in neutropenic febrile children with cancer.

Germs 2017 Jun 1;7(2):61-72. Epub 2017 Jun 1.

MD, PhD, Department of Pathology (Division of Microbiology), Santa Casa de São Paulo School of Medicine, Rua Dr Cesario Mota Junior 61, São Paulo, SP, Brazil.

Introduction: Febrile neutropenia is one of the most serious treatment-related complications in cancer patients. Susceptible to rapidly progressing infections, which result in prolonged hospitalization and use of broad-spectrum antibiotics, neutropenic patients are subject to colonization by multiresistant agents, which enhances the risk of infections.

Methods: In this study we included samples collected with nasal, oropharyngeal and anal swabs from hospitalized children with febrile neutropenia following chemotherapy, between March 2014 and 2015, aiming to elucidate colonization by and spp. Read More

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http://dx.doi.org/10.18683/germs.2017.1110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466824PMC
June 2017
9 Reads

Ileocaecal valve syndrome after surgery in adult patients: myth or reality?

Colorectal Dis 2017 Aug;19(8):e288-e295

Department of Medical, Surgical and Health Sciences, General Surgery Clinic, University Hospital of Trieste, Trieste, Italy.

Aim: The onset of symptoms after removal of the ileocaecal valve (ICV) may be perceived as an unwanted effect of surgery and induce patients to bring unnecessary litigation against surgeons. The aim of our study is to assess the real impact on the quality of life of patients whose ICV has been surgically removed, using three validated questionnaires.

Method: In patients who had their ICV removed surgically, the Gastrointestinal Quality of life (GIQLI) questionnaire and those used by the European Organization for research and Treatment of Cancer (EORTC) were administered before and after surgery. Read More

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http://dx.doi.org/10.1111/codi.13778DOI Listing
August 2017
1 Read

Can complications in febrile neutropenia be predicted? Report from a developing country.

Support Care Cancer 2017 11 11;25(11):3523-3528. Epub 2017 Jun 11.

Division of Pediatric Hematology Oncology, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.

Purpose: Febrile neutropenia (FN) is an important cause of morbidity and mortality in children with acute lymphoblastic leukemia (ALL). We aimed to look at complications in febrile neutropenia and to derive a risk model for developing complications from the variables predicting complications.

Methods: Children on treatment for ALL, presenting with FN, were prospectively enrolled over a period of 1 year. Read More

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http://link.springer.com/10.1007/s00520-017-3776-7
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http://dx.doi.org/10.1007/s00520-017-3776-7DOI Listing
November 2017
26 Reads
2.360 Impact Factor

Ultrasonography-driven combination antibiotic therapy with tigecycline significantly increases survival among patients with neutropenic enterocolitis following cytarabine-containing chemotherapy for the remission induction of acute myeloid leukemia.

Cancer Med 2017 Jul 26;6(7):1500-1511. Epub 2017 May 26.

Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.

Neutropenic enterocolitis (NEC) is an abdominal infection reported primarily in patients with acute myeloid leukemia (AML) following chemotherapy, especially cytarabine, a notable efficacious cytotoxic agent for AML remission. Specific data regarding the impact of different cytarabine schedules and/or antibacterial regimens for NEC are sparse. The aim of the study was to identify the predictors of outcome within 30 days of NEC onset. Read More

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http://dx.doi.org/10.1002/cam4.1063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504336PMC
July 2017
22 Reads

Gastrointestinal emergencies in critically ill cancer patients.

J Crit Care 2017 08 24;40:69-75. Epub 2017 Mar 24.

Medical Intensive Care Unit, Saint-Louis University Hospital, AP-HP, Paris, France. Electronic address:

Purpose: To describe gastrointestinal emergencies in cancer patients.

Methods: All cancer patients admitted to the medical ICU of Saint-Louis Hospital for an acute abdominal syndrome during the study period (1997-2011) were included.

Results: A total of 164 patients were included. Read More

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http://dx.doi.org/10.1016/j.jcrc.2017.03.015DOI Listing
August 2017
13 Reads

Infections in Cancer Patients with Solid Tumors: A Review.

Infect Dis Ther 2017 Mar 3;6(1):69-83. Epub 2017 Feb 3.

The Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Solid tumors are much more common than hematologic malignancies. Although severe and prolonged neutropenia is uncommon, several factors increase the risk of infection in patients with solid tumors, and the presence of multiple risk factors in the same patient is not uncommon. These include obstruction (most often caused by progression of the tumor), disruption of natural anatomic barriers such as the skin and mucosal surfaces, and treatment-related factors such as chemotherapy, radiation, diagnostic and/or therapeutic surgical procedures, and the increasing use of medical devices such as various catheters, stents, and prostheses. Read More

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http://dx.doi.org/10.1007/s40121-017-0146-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336421PMC
March 2017
2 Reads

Neutropenic enterocolitis.

World J Gastroenterol 2017 Jan;23(1):42-47

Fabio G Rodrigues, Giovanna Dasilva, Steven D Wexner, Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL 33331, United States.

Neutropenic colitis is a severe condition usually affecting immunocompromised patients. Its exact pathogenesis is not completely understood. The main elements in disease onset appear to be intestinal mucosal injury together with neutropenia and the weakened immune system of the afflicted patients. Read More

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http://dx.doi.org/10.3748/wjg.v23.i1.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221285PMC
January 2017
7 Reads

Typhlitis (neutropenic enterocolitis) in patients with acute leukemia: a review.

Expert Rev Hematol 2017 Feb 23;10(2):169-174. Epub 2017 Jan 23.

a Department of Internal Medicine , University Hospital, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Typhlitis is an abdominal complication of cancer chemotherapy, affecting mostly patients receiving intensive chemotherapeutic regimens with high potential to induce mucosal damage, such as patients with acute leukemia. Despite being relatively frequent, there are no randomized trials or high-quality cohort studies addressing important aspects of the diagnosis and management of the disease. Areas covered: In this review we discuss the gaps in the literature, acknowledging that the evidences for recommendations regarding the management of typhlitis are mostly expert opinion. Read More

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http://dx.doi.org/10.1080/17474086.2017.1280389DOI Listing
February 2017
12 Reads

Painless neutropenic enterocolitis in a patient undergoing chemotherapy.

Authors:
E J Chow K D Bishop

Curr Oncol 2016 Oct 25;23(5):e514-e516. Epub 2016 Oct 25.

Department of Medicine, Division of Hematology and Oncology, Warren Alpert Medical School of Brown University, Providence, RI, U.S.A.

Case Description: A 60-year-old man developed painless neutropenic enterocolitis after induction chemotherapy for newly diagnosed acute myelogenous leukemia. The patient had recurrent fever while neutropenic, without experiencing abdominal pain or tenderness on physical examination. His diagnosis was delayed by the fact that he had no localizing symptoms. Read More

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http://dx.doi.org/10.3747/co.23.3119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081024PMC
October 2016
2 Reads

Enterovesical fistula as a result of neutropenic enterocolitis in a pediatric patient with acute leukemia.

Pediatr Blood Cancer 2017 04 3;64(4). Epub 2016 Oct 3.

Pediatric Surgery Wards, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1002/pbc.26283DOI Listing
April 2017
8 Reads

An unusual presentation of neutropenic enterocolitis (typhlitis).

Lancet Infect Dis 2016 05 18;16(5):618. Epub 2016 Apr 18.

Department of Haematology, St George's Hospital, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S14733099150039
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http://dx.doi.org/10.1016/S1473-3099(15)00399-0DOI Listing
May 2016
7 Reads

Hypogammaglobulinemia and Poor Performance Status are Predisposing Factors for Vancomycin-Resistant Enterococcus Colonization in Patients with Hematological Malignancies.

Turk J Haematol 2017 Mar 16;34(1):89-92. Epub 2016 Aug 16.

Trakya University Faculty of Medicine, Department of Hematology, Edirne, Turkey Phone: +90 284 235 76 41-2687 E-mail:

Objective: Vancomycin-resistant enterococci (VRE) are common pathogens of hospital-acquired infection. Long hospitalization periods, use of broad-spectrum antibiotics, and immunosuppression are major risks for VRE colonization. We aimed to evaluate patients' characteristics and factors that may contribute to VRE colonization. Read More

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http://dx.doi.org/10.4274/tjh.2016.0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451694PMC
March 2017
5 Reads

Gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy in the years 2000.

World J Gastroenterol 2016 Jul;22(25):5853-66

Elio Castagnola, Infectious Diseases Unit, Istituto Giannina Gaslini, 16147 Genoa, Italy.

Aim: To review gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy. To look at gut microflora features in oncology children.

Methods: We selected studies published after year 2000, excluding trials on transplanted pediatric patients. Read More

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http://dx.doi.org/10.3748/wjg.v22.i25.5853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932220PMC
July 2016
5 Reads

Opening Aeolus' Bag of Winds: Acute Abdominal Pain in a Severely Immunosuppressed Patient.

J Emerg Med 2016 Sep 2;51(3):e29-32. Epub 2016 May 2.

First Department of Surgery, Vascular Unit, "Laikon" General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Background: Necrotizing enterocolitis (NE) is a necrotizing disease mostly of the ileocecal region. It is a severe and potentially life-threatening complication that can affect patients undergoing chemotherapy for lymphoma. We analyze a case of NE that occurred in a patient with non-Hodgkin's lymphoma during chemotherapy with concurrent HIV infection. Read More

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http://dx.doi.org/10.1016/j.jemermed.2015.08.028DOI Listing
September 2016
3 Reads

Early-Onset Neutropenia in Small-for-Gestational-Age Infants.

Pediatrics 2015 Nov 12;136(5):e1259-67. Epub 2015 Oct 12.

Statistical Data Center, LDS Hospital, Salt Lake City, Utah.

Background: Early neutropenia is more common in small for gestational age (SGA) neonates (birth weight <10th percentile) than in appropriately grown neonates. However, several aspects of this variety of neutropenia are unknown, including the duration, kinetic mechanism, and outcomes.

Methods: Using 10 years of multihospital records, we studied SGA neonates who, during the first week after birth, had neutrophil counts <1000/μL. Read More

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http://pediatrics.aappublications.org/content/pediatrics/ear
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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2015-1638DOI Listing
November 2015
4 Reads

Neutropenic Enterocolitis: New Insights Into a Deadly Entity.

Am J Surg Pathol 2015 Dec;39(12):1635-42

*The Ohio State University Wexner Medical Center †Nationwide Children's Hospital, Columbus ∥Cleveland Clinic, Cleveland, OH ‡Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA §Mayo Clinic, Rochester, MN ¶Children's Medical Center of Dallas #University of Texas Southwestern Medical Center, Dallas, TX **Department of Pathology and Laboratory Services, University of Arkansas for Medical Sciences, Little Rock, AR.

Neutropenic enterocolitis (NE) is a deadly ileocecal-based disease seen in patients with a recent history of chemotherapy. As histology is not included in the current diagnostic criteria, the pathologic features of NE are poorly understood. We undertook a multi-institutional study of NE, and report helpful clinical clues, such as immunosuppression (n=20/20), recent chemotherapy (n=17/18), neutropenia (n=16/18) gastrointestinal symptoms (n=19/19), abnormal imaging studies of the cecum/right colon (n=11/14), and positive microbiological studies (n=13/15). Read More

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http://dx.doi.org/10.1097/PAS.0000000000000517DOI Listing
December 2015
21 Reads

[Ipilimumab-induced colitis: A new challenge for gastroenterologists].

Gastroenterol Hepatol 2016 Mar 20;39(3):233-8. Epub 2015 Aug 20.

Servicio de Oncología Médica, Hospital Universitario Ramón y Cajal, Madrid, España.

Many drugs can produce enterocolitis and they should always be included in the differential diagnosis of this clinical picture. Entities such as antibiotic-associated colitis and neutropenic colitis have been known for some time and recently a new type of drug-induced colitis has emerged due to monoclonal antibodies. Ipimumab is a humanized monoclonal antibody against the CTLA4 molecule that is involved in the maturation and regulation of T lymphocyte activation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02105705150014
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http://dx.doi.org/10.1016/j.gastrohep.2015.06.005DOI Listing
March 2016
5 Reads

A Multidisciplinary Approach to Perianal and Intra-Abdominal Infections in the Neutropenic Cancer Patient.

Oncology (Williston Park) 2015 Aug;29(8):581-90

The chemotherapeutic treatment of both hematologic and solid organ malignancies has increased in recent decades, resulting in increased neutropenia-related perianal and intra-abdominal infections. Nearly 30% of neutropenia-related infections arise in the gastrointestinal tract. The management of these patients is often not straightforward, and the indications for and timing of surgical intervention continue to be unclear. Read More

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August 2015
16 Reads

Osteomyelitis due to Clostridium innocuum in a patient with acute lymphoblastic leukemia: case report and literature review.

Springerplus 2015 29;4:385. Epub 2015 Jul 29.

Division of Hematology, Department of Internal Medicine, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo, 162-8655 Japan.

Introduction: Clostridium innocuum is an anaerobic Gram-positive bacterium, unable to produce toxins and rarely causes infections. We report the first case of C. innocuum osteomyelitis and bacteremia in a patient with acute lymphoblastic leukemia (ALL). Read More

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http://www.springerplus.com/content/4/1/385
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http://dx.doi.org/10.1186/s40064-015-1176-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518021PMC
August 2015
7 Reads

Noninfectious colitides.

Clin Colon Rectal Surg 2015 Jun;28(2):87-92

Section of Colon and Rectal Surgery, MedStar Washington Hospital Center, Washington, District of Columbia.

There are numerous etiologic and pathogenic mechanisms associated with colitis, ranging from infectious to noninfectious colitis. However, despite their different causes, their presentations are often similar making it difficult to formulate the correct diagnosis. This article describes the presentation, endoscopic and pathological findings of six different noninfectious colitides: diversion colitis, neutropenic enterocolitis, disinfectant colitis, corrosive colitis, nonsteroidal anti-inflammatory drug and salicylate-induced colitis, and toxic epidermal necrolysis. Read More

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http://dx.doi.org/10.1055/s-0035-1549847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442723PMC
June 2015
2 Reads

Clinical features of life-threatening complications following autologous stem cell transplantation in patients with lymphoma.

Leuk Lymphoma 2015 12;56(11):3090-5. Epub 2015 May 12.

a Medical Intensive Care Unit, Saint Louis University Hospital , Paris , France.

Toxic effects of high dose therapy (HDT) combined with autologous stem cell transplantation (ASCT) can lead to life-threatening conditions that may require intensive care unit (ICU) admission. We conducted a retrospective observational study over a 10-year period of all patients admitted to the ICU within 3 months after HDT/ASCT for lymphoma. Among the 532 patients treated by HDT/ASCT at our hospital, 27 (5%) were admitted to the ICU. Read More

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http://dx.doi.org/10.3109/10428194.2015.1034700DOI Listing
September 2016
4 Reads

[Fatal neutropenic enterocolitis in a patient with castration-resistant prostate cancer treated with first-line chemotherapy].

Ugeskr Laeger 2015 Jan;177(2A):24-5

Vesterbrogade 51, 4. tv., 1620 København V.

Neutropenic enterocolitis (NE) is a possible life-threatening complication to chemotherapy. The pathogenesis is multi-factorial with mucosal injury and impaired mucosal defence as contributing factors. Histopathological findings are heterogeneous. Read More

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January 2015
5 Reads

Prognosis of neutropenic patients admitted to the intensive care unit.

Intensive Care Med 2015 Feb 13;41(2):296-303. Epub 2015 Jan 13.

Polyvalent Intensive Care Unit, Department of Anesthesiology and Critical Care, Institut Paoli Calmettes, 232 Boulevard Sainte Marguerite, 13009, Marseille Cedex 09, France,

Purpose: The prognosis of critically ill cancer patients has improved recently. Controversies remain as regard to the specific prognosis impact of neutropenia in critically ill cancer patients. The primary objective of this study was to assess hospital outcome of critically ill neutropenic cancer patients admitted into the ICU. Read More

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http://dx.doi.org/10.1007/s00134-014-3615-yDOI Listing
February 2015
1 Read

How to treat severe infections in critically ill neutropenic patients?

BMC Infect Dis 2014 Nov 28;14:512. Epub 2014 Nov 28.

AP-HP, Hôpital Saint-Louis, Medical ICU, Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique (Grrr-OH), Paris, France.

Severe infections in neutropenic patient often progress rapidly leading to life-threatening organ dysfunction requiring admission to the Intensive Care Unit. Management strategies include early adequate appropriate empirical antimicrobial, early admission to ICU to avoid any delay in the diagnostic and therapeutic management of organ dysfunction. This review discusses the main clinical situations encountered in critically ill neutropenic patients. Read More

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http://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-
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http://dx.doi.org/10.1186/1471-2334-14-512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289060PMC
November 2014
6 Reads

Neutropenic enterocolitis secondary to propylthiouracil-induced agranulocytosis.

Turk J Gastroenterol 2014 Oct;25(5):588-9

Department of General Surgery, Bozyaka Training and Research Hospital, İzmir, Turkey.

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http://dx.doi.org/10.5152/tjg.2014.3761DOI Listing
October 2014
11 Reads

Biosimilar granulocyte colony-stimulating factor is effective in reducing the duration of neutropenia after autologous peripheral blood stem cell transplantation.

Transplant Proc 2014 Oct;46(8):2882-4

Department of Haematooncology and Bone Marrow Transplantation, Medical University in Lublin, Lublin, Poland.

Background: Autologous peripheral blood stem cell transplantation (APBSCT) is the standard of therapy for patients with multiple myeloma and refractory Hodgkin's and non-Hodgkin's lymphomas. Granulocyte colony-stimulating factor (G-CSF) is widely used to accelerate hematopoietic recovery after transplantation and to reduce the morbidity and mortality associated with prolonged neutropenia. Biosimilar G-CSF is approved for the same indications as the originator G-CSF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345140085
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http://dx.doi.org/10.1016/j.transproceed.2014.09.070DOI Listing
October 2014
11 Reads

Incidence of diarrhea by Clostridium difficile in hematologic patients and hematopoietic stem cell transplantation patients: risk factors for severe forms and death.

Rev Inst Med Trop Sao Paulo 2014 Jul-Aug;56(4):325-31

Infectious Diseases Department, Unversity of São Paulo, Brazil.

We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors associated with the severe form of the disease and death. The ELISA method (Ridascreen-Biopharm, Germany) for the detections of toxins A/B was used to identify C. difficile. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131819PMC
October 2014
65 Reads

Neutropenic enterocolitis affecting the transverse colon: an unusual complication of chemotherapy.

BMJ Case Rep 2014 May 2;2014. Epub 2014 May 2.

Inverclyde Royal Hospital, Greenock, UK.

A 66-year-old woman presented with a 1-day history of sudden onset of generalised abdominal pain associated with fever and vomiting. She was previously diagnosed with left breast cancer 2 months ago and completed a course of chemotherapy 1 week prior to presentation. She was clinically unwell with generalised tenderness in her abdomen. Read More

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http://dx.doi.org/10.1136/bcr-2014-204035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025389PMC
May 2014
3 Reads

Atypical presentation of 'acalculous cholecystitis' with marked isolated hyperbilirubinaemia in patients treated for haematological malignancies.

Eur J Haematol 2015 Feb 21;94(2):182-5. Epub 2014 May 21.

Department of Haematology, RadboudUMC, Nijmegen, the Netherlands.

Four patients diagnosed with haematological malignancies developed an isolated hyperbilirubinaemia following cytarabine- and anthracycline-based chemotherapy. The clinical picture was consistent with acalculous cholecystitis, but ultrasonography did not show the typical gallbladder wall thickening. All patients suffered from severe mucositis with neutropenic enterocolitis. Read More

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http://dx.doi.org/10.1111/ejh.12357DOI Listing
February 2015
4 Reads

[Neutropenic enterocolitis after autologous peripheral blood stem cell transplantation in non-Hodgkin's lymphoma - a case report].

Gan To Kagaku Ryoho 2014 Apr;41(4):513-5

Dept. of Hematology, Seichokai Fuchu Hospital.

Here we report a case of a 59-year-old man who developed neutropenic enterocolitis(NE)after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma in his second complete remission.Four days after transplantation, the patient suffered from diarrhea, abdominal pain, fever, and paralytic ileus.Abdominal computerized tomography scan revealed bowel wall thickening consistent with NE. Read More

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April 2014
9 Reads

Spontaneous intestinal perforation: an atypical presentation of neutropenic enterocolitis-a case report.

Case Rep Hematol 2014 6;2014:925078. Epub 2014 Mar 6.

Pediatric Surgery Department, Goztepe Education and Research Hospital, Istanbul Medeniyet University, 34722 Istanbul, Turkey.

Background. Neutropenic enterocolitis is one of the most common gastrointestinal complications seen in patients who are receiving chemotherapy for leukemia. Severe neutropenia is the main underlying factor of this pathology. Read More

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http://dx.doi.org/10.1155/2014/925078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970456PMC
April 2014
17 Reads

Enteric infections.

Cancer Treat Res 2014 ;161:237-51

Division of Infectious Diseases, Lakeland Regional Medical Center, 1234 Napier Avenue, St. Joseph, MI, 49085, USA,

Cancer patients, particularly those with neutropenia, are at risk for enteric and intra-abdominal infections. Specific infections and infectious syndromes in this setting include neutropenic enterocolitis, bacterial infections such as Clostridium difficile infection (CDI), viral infections such as CMV colitis, and parasitic infections such as strongyloidiasis. Diagnosing and gauging the severity of CDI presents challenges, as chemotherapy may produce symptoms that mimic CDI and laboratory findings such as leukocytosis are not reliable in this population. Read More

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http://dx.doi.org/10.1007/978-3-319-04220-6_8DOI Listing
June 2014
2 Reads

Clostridium difficile infection in patients with acute myelogenous leukemia and in patients undergoing allogeneic stem cell transplantation: epidemiology and risk factor analysis.

Biol Blood Marrow Transplant 2014 06 6;20(6):823-8. Epub 2014 Mar 6.

First Department of Internal Medicine, University of Cologne, Cologne, Germany; German Centre for Infection Research (DZIF), Partner site Bonn-Cologne, Germany.

Patients receiving treatment for acute myelogenous leukemia (AML) and recipients of allogeneic stem cell transplantation (aSCT) are at high risk of contracting Clostridium difficile infection (CDI), the most frequently observed nosocomial diarrhea and enterocolitis. Data were retrieved from the prospective Cologne Cohort of Neutropenic Patients. Patients hospitalized for aSCT as well as patients receiving treatment for AML were included in the analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10838791140014
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http://dx.doi.org/10.1016/j.bbmt.2014.02.022DOI Listing
June 2014
11 Reads

[19-year old male with Crohn's disease complicated by retroperitoneal abscesses and coxarthritis dexter].

Wiad Lek 2013 ;66(3):244-8

Oddział Chirurgii z Pododdziałem Urazów Narzadu Ruchu i Ortopedii w Krotoszynie.

The article presents the case of a patient with Crohn's disease in whom an infection of the complex ileo-caecal be spread into the retroperitoneal space and the right hip. Read More

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September 2015
6 Reads