480 results match your criteria Neutropenic Enterocolitis


Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer.

Case Rep Oncol Med 2020 16;2020:7231358. Epub 2020 Jun 16.

Department of Breast and Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. Read More

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http://dx.doi.org/10.1155/2020/7231358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317333PMC

Neutropenic Enterocolitis in the Treatment of Solid Tumors: A Case Report and Review of the Literature.

Case Rep Oncol 2020 Jan-Apr;13(1):442-448. Epub 2020 Apr 22.

Department of Oncology, Fondazione Poliambulanza, Brescia, Italy.

Neutropenic enterocolitis is a clinical condition characterized by inflammation of the colic mucosa, usually the caecum, associated with bowel wall thickening in patients with compromised immune system due to chemotherapy treatments. It can occur as well in other clinical conditions that lead to immunosuppression. Clinically, patients present with abdominal pain, fever, and neutropenia on blood tests. Read More

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http://dx.doi.org/10.1159/000506896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204860PMC

Hepatic Portal Venous Gas: An Ill Omen or a Misleading Sign.

Surg J (N Y) 2020 Jan 3;6(1):e37-e41. Epub 2020 Mar 3.

Department of Internal Medicine and Medical Gastroenterology, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.

Hepatic portal venous gas (HPVG), a rare radiological finding, is historically considered an ominous sign with 100% mortality rates. The dictum that HPVG warrants surgical intervention is challenged in the recent literature. This is because of the identification of various causes of HVPG other than bowel gangrene. Read More

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http://dx.doi.org/10.1055/s-0040-1702919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054055PMC
January 2020

Chemotherapy-associated neutropenic enterocolitis of the transverse colon post right hemicolectomy.

Oxf Med Case Reports 2019 Nov 19;2019(11):omz140. Epub 2019 Dec 19.

Metropolitan Group Hospitals General Surgery Residency, Advocate Illinois Masonic Hospital, University of Illinois, Chicago, IL, USA.

Neutropenic enterocolitis (NE) is a life-threatening infection of the immunocompromised. NE ubiquitously affects the cecum, often with involvement of the ascending colon and ileum. Classically, NE is associated with high mortality leading to the frequent use of aggressive treatment strategies including surgery. Read More

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http://dx.doi.org/10.1093/omcr/omz140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924534PMC
November 2019

Neutropenic Enterocolitis: Clinical Features and Outcomes.

Dis Colon Rectum 2020 03;63(3):381-388

Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Patients undergoing chemotherapy are at risk for mucosal injury and neutropenia, which facilitate colonic mucosal invasion by the bowel flora and subsequent neutropenic enterocolitis, which has a poor prognosis.

Objective: This study aimed to assess the clinical features and outcomes of neutropenic enterocolitis in patients at a comprehensive cancer center.

Design: This is a retrospective cohort study. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001548DOI Listing
March 2020
5 Reads
3.749 Impact Factor

Pharmacokinetics of doxorubicin following concomitant intravenous administration of olaratumab (IMC-3G3) to patients with advanced soft tissue sarcoma.

Cancer Med 2020 Feb 10;9(3):882-893. Epub 2019 Dec 10.

Eli Lilly and Company, Indianapolis, IN, USA.

Background: Olaratumab, a fully human monoclonal antibody, selectively binds to human platelet-derived growth factor receptor alpha and blocks ligand binding. This study assessed the effect of olaratumab on the pharmacokinetics (PK) of doxorubicin and the safety of olaratumab alone and in combination with doxorubicin.

Methods: This open-label randomized phase 1 trial enrolled 49 patients ages 27 to 83 with metastatic or locally advanced soft tissue sarcoma (STS). Read More

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http://dx.doi.org/10.1002/cam4.2728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997100PMC
February 2020

Neutropenic enterocolitis: A clinico-pathological review.

World J Gastrointest Pathophysiol 2019 Oct;10(3):36-41

Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, United States.

Neutropenic enterocolitis (NE) is a predominantly cecum-based disease with high mortality seen in patients post chemotherapy. The pathogenesis of NE is poorly understood and probably multifactorial involving mucosal injury, neutropenia, and impaired host defense to intestinal organisms. The clinical presentation is characterized as ileocolonic inflammation and bowel wall thickening in patients with neutropenia, fever, and abdominal pain. Read More

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http://dx.doi.org/10.4291/wjgp.v10.i3.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829094PMC
October 2019
1 Read

Fatal neutropenic enterocolitis associated with docetaxel use: A review of cases reported to the United States Food and Drug Administration Adverse Event Reporting System.

J Oncol Pharm Pract 2020 Jun 8;26(4):923-928. Epub 2019 Oct 8.

Division of Pharmacovigilance, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.

Docetaxel is a microtubule inhibitor indicated for the treatment of multiple cancers as a single agent or in combination with other antineoplastics. The U.S. Read More

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http://dx.doi.org/10.1177/1078155219879494DOI Listing
June 2020
1 Read

Adult Necrotising Enterocolitis in a Breast Cancer Patient after First Cycle of Adjuvant Chemotherapy.

J Coll Physicians Surg Pak 2019 Oct;29(10):1006-1008

Department of Surgery, Islamabad Medical Complex, Nescom, Islamabad, Pakistan.

Chemotherapy-induced diarrhea has become a worrisome problem for the patients as well as the treating surgeons and oncologists because patient outcome is significantly affected. Necrotising enterocolitis is a rare disease in adults. It is now termed as neutropenic enterocolitis in adults, because it is seen more often as a complication of aggressive systemic chemotherapy. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.10.1006DOI Listing
October 2019
2 Reads

Intussusception caused by typhlitis: a rare complication in a patient with acute lymphoblastic leukemia after chemotherapy.

Int J Colorectal Dis 2019 Oct 11;34(10):1815-1818. Epub 2019 Sep 11.

Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Introduction: Intussusception, which is common in pediatric patients but rare in adults with leukemia, usually presents with an intralumenal lesion as a lead point in adults.

Case Report: We herein report the case of a 38-year-old female who developed right lower quadrant abdominal pain and fever on day 16 of chemotherapy. Abdominal computed tomography showed ileocecal intussusception. Read More

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http://dx.doi.org/10.1007/s00384-019-03395-yDOI Listing
October 2019
1 Read

Fatal parasite-induced enteritis and typhlocolitis in horses in Southern Brazil.

Rev Bras Parasitol Vet 2019 Aug 1;28(3):443-450. Epub 2019 Aug 1.

Setor de Patologia Veterinária, Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brasil.

Diseases related to the alimentary system are the main cause of death in horses. This retrospective study aimed to describe the pathological findings of fatal parasite-induced enteritis and typhlocolitis caused by cyathostominae, Eimeria leuckarti, Balantidium coli, and Strongyloides westeri in horses. The records of parasite-induced intestinal lesions in horses necropsied in Southern Brazil between 2005 and 2017 were reviewed. Read More

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http://dx.doi.org/10.1590/S1984-29612019056DOI Listing

[Antimicrobial therapy in cancer patients and hematopoietic stem cell transplantation receptors].

Rev Chilena Infectol 2019 Apr;36(2):167-178

Servicio de Farmacia Clínica, Hospital Exequiel González Cortés, Santiago, Chile.

This manuscript includes the antiinfective therapeutic resources for immunocompromised patients under chemotherapy by cancer or hematopoietic stem cells transplant (HSCT) receptors. The document presents the antimicrobial therapy indicated in the most prevalent clinical situations in this population and the primary and alternative therapy for some specific microorganisms. The clinical situations included in the analysis are: febrile neutropenia without focus, sepsis, infections of the central nervous system, pneumonia, skin and soft tissue infections, neutropenic enterocolitis and urinary tract infection. Read More

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http://dx.doi.org/10.4067/S0716-10182019000200167DOI Listing
April 2019
4 Reads

Impact of inflammation on brain subcellular energetics in anesthetized rats.

BMC Neurosci 2019 07 15;20(1):34. Epub 2019 Jul 15.

Department of Anesthesiology, University of Virginia School of Medicine, P.O. Box 800710, Charlottesville, VA, 22908-0710, USA.

Background: Emerging data suggests that volatile anesthetic agents may have organ protection properties in the setting of critical illness. The purpose of this study was to better understand the effect of inflammation on cerebral subcellular energetics in animals exposed to two different anesthetic agents-a GABA agonist (propofol) and a volatile agent (isoflurane).

Results: Forty-eight Sprague-Dawley rats were anesthetized with isoflurane or propofol. Read More

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http://dx.doi.org/10.1186/s12868-019-0514-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631861PMC

Clostridium difficile colitis: CT findings and differential diagnosis.

Radiol Med 2019 Dec 13;124(12):1185-1198. Epub 2019 Jul 13.

Department of Radiology, Azienda Ospedaliero-Universitaria Careggi, Largo G.A. Brambilla 3, 50134, Florence, Italy.

Clostridium difficile infection (CDI) is a severe and potentially deadly infectious colitis whose incidence is dramatically increasing in the last decades, with more virulent strains. CDI should be suspected in case of unexplained diarrhea and abdominal pain in patients with a recent history of antibiotic use and healthcare exposures; diagnosis is based on a combination of clinical and laboratory findings with demonstration of C. difficile toxins by stool test. Read More

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http://dx.doi.org/10.1007/s11547-019-01066-0DOI Listing
December 2019
2 Reads

The Authors' Reply to "The Addition of Prophylactic Antibiotics Can Achieve a Favorable Outcome".

Intern Med 2019 08 17;58(16):2421. Epub 2019 Apr 17.

Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2793-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746649PMC
August 2019
5 Reads

The Addition of Prophylactic Antibiotics Can Achieve a Favorable Outcome.

Intern Med 2019 08 17;58(16):2419. Epub 2019 Apr 17.

Division of General Medicine, Jichi Medical University Saitama Medical Center, Japan.

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
Publisher Site
http://dx.doi.org/10.2169/internalmedicine.2661-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746644PMC
August 2019
25 Reads
0.967 Impact Factor

Factors associated with emergent colectomy in patients with neutropenic enterocolitis.

Langenbecks Arch Surg 2019 May 5;404(3):327-334. Epub 2019 Apr 5.

Department of Colorectal Surgery, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Vasco de Quiroga, 15, Sección XVI, Tlalpan, 14080, Mexico City, Mexico.

Purpose: Neutropenic enterocolitis (NEC) is a severe complication of neutropenia. NEC is characterized by segmental ulceration, intramural inflammation, and necrosis. Factors present in patients who underwent colectomy have never been studied. Read More

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http://dx.doi.org/10.1007/s00423-019-01781-2DOI Listing
May 2019
13 Reads
2.160 Impact Factor

Complications of Stem Cell Transplantation that Affect Infections in Stem Cell Transplant Recipients, with Analogies to Patients with Hematologic Malignancies.

Infect Dis Clin North Am 2019 06 30;33(2):331-359. Epub 2019 Mar 30.

Section of Bone Marrow Transplant and Cellular Therapy, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, 1725 West Harrison Street, Suite 809, Chicago, IL 60612, USA. Electronic address:

This article discusses the complications of hematopoietic stem cell transplantion (HSCT) that affect infections in HSCT recipients, with analogies to patients with hematologic malignancies. Mucositis, with mucosal barrier disruption, is common and increases the risk of gram-positive and anaerobic bacterial, and fungal infections, and can evolve to typhlitis. Engraftment syndrome; graft-versus-host disease, hepatic sinusoidal obstruction syndrome; and posterior reversible encephalopathy syndrome can affect the infectious potential either directly from organ dysfunction or indirectly from specific treatment. Read More

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http://dx.doi.org/10.1016/j.idc.2019.01.002DOI Listing
June 2019
28 Reads

Severe ileocecal inflammatory syndrome in adult patients with cystic fibrosis.

Z Gastroenterol 2019 Mar 12;57(3):312-316. Epub 2019 Mar 12.

University Hospital Leipzig, Division of Gastroenterology, Leipzig, Germany.

The relevance of gastrointestinal manifestations of cystic fibrosis (CF) is increasing due to an improved life expectancy. We report on 2 adult patients with prior lung transplantation who presented with a severe inflammatory disorder of the ileocecal region. One patient underwent ileocecal resection; the second patient died after emergency surgery for intestinal perforation. Read More

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http://dx.doi.org/10.1055/a-0829-7050DOI Listing
March 2019
8 Reads
1.671 Impact Factor

Pathology of Gastrointestinal and Liver Complications of Hematopoietic Stem Cell Transplantation.

Arch Pathol Lab Med 2019 09 6;143(9):1131-1143. Epub 2019 Mar 6.

Faculté de médecine, département de biologie moléculaire, de biochimie médicale et de pathologie, Université Laval, Hôpital du Saint-Sacrement - CHU de Québec, Québec, Québec, Canada (Dr Mourad); the Department of Pathology, McGill University and McGill University Health Center, Montreal, Quebec, Canada (Drs Michel and Marcus).

Context.—: Despite advances in therapeutic and preventive measures, hematopoietic stem cell transplant recipients remain at risk for a variety of gastrointestinal and liver complications.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0282-RADOI Listing
September 2019
8 Reads

Bowel Imaging in Children: Part 2.

Indian J Pediatr 2019 09 21;86(9):817-829. Epub 2019 Feb 21.

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, 110029, India.

The bowel is a challenging abdominal organ to image. A variety of bowel disorders such as congenital, developmental, inflammatory, infectious and neoplastic lesions can affect children and most of them are either unique to this age group or have a distinct clinico-radiological appearance compared to adults. Imaging forms an integral part of management of these disorders. Read More

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http://dx.doi.org/10.1007/s12098-019-02878-8DOI Listing
September 2019
16 Reads

Neutropenic Enterocolitis in Critically Ill Patients: Spectrum of the Disease and Risk of Invasive Fungal Disease.

Crit Care Med 2019 05;47(5):668-676

Medical Intensive Care Unit, Hospital Saint Louis, Assistance Publique-Hôpitaux de Paris, France.

Objectives: Neutropenic enterocolitis occurs in about 5.3% of patients hospitalized for hematologic malignancies receiving chemotherapy. Data from critically ill patients with neutropenic enterocolitis are scarce. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003687DOI Listing
May 2019
9 Reads

Gastrointestinal mucormycosis in a child with acute lymphoblastic leukemia: An uncommon but ominous complication.

Indian J Cancer 2018 Jul-Sep;55(3):304-305

Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

Invasive fungal infections constitute a major cause of morbidity and mortality in children undergoing therapy for hematological malignancies. We report a 1-year-old boy who was receiving chemotherapy for acute lymphoblastic leukemia. His clinical course was complicated by a clinical syndrome consistent with neutropenic enterocolitis to which he succumbed. Read More

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http://dx.doi.org/10.4103/ijc.IJC_260_18DOI Listing
June 2019
14 Reads

Neutropenic enterocolitis in patients with FLT3 mutated acute myeloid leukemia undergoing induction chemotherapy with midostaurin.

Int J Hematol 2019 Mar 3;109(3):351-355. Epub 2018 Dec 3.

Department of Hematology and Oncology, Marshall University, 1400 Hal Greer Blvd, Huntington, WV, 25701, USA.

Neutropenic enterocolitis mostly affects patients with acute myeloid leukemia (AML) who get treated with intensive chemotherapy which is associated with prolonged neutropenia; its pathogenesis is not well understood and the main factors in this life-threatening condition appear to be neutropenia, mucosal injury and a weakened immune system as a consequence of intensive chemotherapeutic agents. Midostaurin in combination with chemotherapy became the standard of care for FLT3 mutant AML since its approval by the United States Food and Drug Administration (FDA) in April 2017. Anecdotally in our institution, we noticed the common occurrence of neutropenic colitis in three out of three patients who were treated with midostaurin as part of induction chemotherapy for AML. Read More

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http://dx.doi.org/10.1007/s12185-018-2558-4DOI Listing
March 2019
9 Reads

Ultrasound diagnosis of typhlitis.

J Ultrasound 2019 Mar 27;22(1):103-106. Epub 2018 Oct 27.

Department of Radiology-Ospedale del Mare-ASL NA1 Centro-Napoli, Naples, Italy.

Purpose: Typhlitis, also known as neutropenic colitis, is a rare inflammatory condition and a potentially life-threatening disease process that typically involves the cecum. Delay in diagnosis may lead to a fatal prognosis with a death rate of 21-48%. Ultrasound evaluation of right lower quadrant may lead to an accurate and rapid diagnosis. Read More

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http://link.springer.com/10.1007/s40477-018-0333-2
Publisher Site
http://dx.doi.org/10.1007/s40477-018-0333-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430296PMC
March 2019
59 Reads

Neutropenic Enterocolitis due to Mucormycosis in a Patient with Myelodysplastic Syndrome.

Infect Chemother 2020 Mar 12;52(1):98-104. Epub 2018 Sep 12.

Division of Hematology-Oncology, Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Neutropenic enterocolitis is a fatal enterocolitis occurring in neutropenic patients with immunocompromised diseases including hematologic malignancies. Gastrointestinal (GI) mucormycosis in hematologic malignancies has been rarely reported. Especially, in myelodysplastic syndrome (MDS), GI mucormycosis has never been reported. Read More

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http://dx.doi.org/10.3947/ic.2020.52.1.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113448PMC

A randomized placebo-controlled phase II study of clarithromycin or placebo combined with VCD induction therapy prior to high-dose melphalan with stem cell support in patients with newly diagnosed multiple myeloma.

Exp Hematol Oncol 2018 13;7:18. Epub 2018 Aug 13.

8Department of Hematology, Odense University Hospital, 5000 Odense C, Denmark.

Background: The objective of this randomized placebo-controlled study was to investigate the efficacy and safety of clarithromycin in combination with bortezomib-cyclophosphamide-dexamethasone (VCD) in patients with newly diagnosed multiple myeloma eligible for high-dose therapy.

Methods: Patients were randomized to receive tablet clarithromycin 500 mg or matching placebo tablet twice daily during the first 3 cycles of VCD induction therapy. Primary endpoint was to compare the rate of very good partial response (VGPR) or better response after three cycles of VCD combined with clarithromycin or placebo. Read More

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http://dx.doi.org/10.1186/s40164-018-0110-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090810PMC
August 2018
33 Reads

Fatal Neutropenic Enterocolitis Caused by Stenotrophomonas maltophilia: A Rare and Underrecognized Entity.

Intern Med 2018 Dec 10;57(24):3667-3671. Epub 2018 Aug 10.

Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan.

Although Stenotrophomonas maltophilia causes substantial morbidity and mortality in immunocompromised patients, it has not been described as a causal pathogen of neutropenic enterocolitis (NEC). We describe the first case of histologically-confirmed NEC caused by S. maltophilia accompanied by bacteremia and pneumonia after salvage chemotherapy for acute myeloid leukemia relapse following a second hematopoietic stem cell transplantation. Read More

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http://dx.doi.org/10.2169/internalmedicine.1227-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355424PMC
December 2018
6 Reads

Typhlitis as a complication of influenza in a patient with advanced HIV infection.

Postgrad Med 2018 Sep 11;130(7):650-651. Epub 2018 Aug 11.

c Hospital of Virnaroz , Castellon , Spain.

The authors report the case of an HIV-infected patient who presented with typhlitis as a complication of typical influenza. To the best of their knowledge, this is the first case reported in the literature with such an association of clinical conditions. Read More

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http://dx.doi.org/10.1080/00325481.2018.1508984DOI Listing
September 2018
1 Read

Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants.

Case Rep Transplant 2018 8;2018:3264921. Epub 2018 May 8.

UCLA Mattel Children's Hospital, Pediatric Heart Transplant Program, 200 UCLA Medical Plaza Suite 330, Los Angeles, CA 90024, USA.

Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the first published case of NE occurring in the setting of pediatric heart transplant. This patient was diagnosed several months after pediatric heart transplant, with radiographs showing evidence of pneumatosis intestinalis. Read More

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http://dx.doi.org/10.1155/2018/3264921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964482PMC
May 2018
18 Reads

The prognostic impact of abdominal surgery in cancer patients with neutropenic enterocolitis: a systematic review and meta-analysis, on behalf the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH).

Ann Intensive Care 2018 Apr 19;8(1):47. Epub 2018 Apr 19.

GRRR-OH (Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie), Paris, France.

Neutropenic enterocolitis (NE) is a diagnostic and therapeutic challenge associated with high mortality rates, with controversial opinions on its optimal management. Physicians are usually reluctant to select surgery as the first-choice treatment, concerns being raised regarding the potential risks associated with abdominal surgery during neutropenia. Nevertheless, no published studies comforted this idea, literature is scarce and surgery has never been compared to medical treatment. Read More

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http://dx.doi.org/10.1186/s13613-018-0394-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908777PMC
April 2018
42 Reads

Acute myositis: an unusual and severe side effect of docetaxel: a case report and literature review.

Anticancer Drugs 2018 06;29(5):477-481

Departments of Medical Oncology.

Docetaxel is an antimicrotubules cytotoxic agent prescribed widely by medical oncologists in multiple tumor types (breast, lung, prostate, stomach, head, and neck). However, the side effects of docetaxel are numerous (cytopenia, peripheral edema, myalgia, arthralgia, alopecia, and sensitive neuropathy) and recent concerns have been raised about neutropenic enterocolitis in France. Here, we report the case of a 57-year-old patient with metastatic prostatic cancer, who developed a severe myositis and fasciitis grade IV 1 week after his second docetaxel infusion. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000620DOI Listing
June 2018
14 Reads

Similar incidence of typhlitis in patients receiving various doses of daunorubicin or idarubicin as induction for acute myeloid leukemia.

Leuk Res 2018 05 8;68:48-50. Epub 2018 Mar 8.

Leukemia Service, Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: The current standard of care for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) is an anthracycline plus cytarabine. Both anthracyclines and cytarabine have been associated with the development of typhlitis, a serious adverse event characterized by inflammation of the bowel wall in patients with profound neutropenia, diagnosed by abdominal CT imaging and clinical symptoms. Given the paucity of available data, the aim of our study was to determine the incidence of typhlitis among AML patients receiving induction chemotherapy with idarubicin 12 mg/m (IDA), daunorubicin 60 mg/m (DNA60), or daunorubicin 90 mg/m (DNA90). Read More

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http://dx.doi.org/10.1016/j.leukres.2018.03.004DOI Listing
May 2018
18 Reads

Gastrointestinal: Unusual cause of ileocecal thickening in an immunocompromised patient: A histologic surprise.

J Gastroenterol Hepatol 2018 Apr;33(4):769

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1111/jgh.13994DOI Listing
April 2018
8 Reads

Clinical Presentation, Prognostic Factors, and Outcome in Neutropenic Enteropathy of Childhood Leukemia.

J Pediatr Hematol Oncol 2018 04;40(3):216-220

Departments of Pediatric Surgery.

Leukemia patients are at risk for neutropenic enteropathy (NEP) because of the effects of intensified chemotherapy. Medical records of 18 patients having 20 episodes of NEP were reviewed retrospectively. Primary diagnosis was acute lymphoblastic leukemia in 12 and myeloblastic leukemia in 6 cases. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001065DOI Listing
April 2018
15 Reads

Clinical Salmonellosis in a Closed Colony of Blood Donor Cats.

Comp Med 2017 Dec;67(6):524-528

Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia.

An adult feline blood donor, group-housed in a closed colony with other blood donor cats in a laboratory animal facility, developed anorexia, abdominal pain, an abdominal mass effect, and hemorrhagic diarrhea. Ultimately Salmonella infection was diagnosed. The index cat and 2 additional cats in the closed colony had clinical signs consistent with Salmonella and yielded Salmonella serotype 4,12:i:- in fecal cultures. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713168PMC
December 2017
14 Reads

Mucosal Biopsy After Bone Marrow Transplantation.

Surg Pathol Clin 2017 Dec 27;10(4):909-930. Epub 2017 Sep 27.

Department of Pathology, University of Michigan, 5231F, 1301 Catherine Street, Ann Arbor, MI 48109-5602, USA.

Gastrointestinal mucosal biopsies in the hematopoietic stem cell transplantation setting are challenging because histologic features of graft-versus-host disease (GVHD), which is treated by increasing immunosuppression, overlap with those of other conditions, such as infection, which can get worse with GVHD treatment. More than one condition can occur at the same time. It is important to understand the histologic features of GVHD, drug toxicity, infection, and clinical factors surrounding patients, including timing of biopsy in relation to transplantation, medication history, and laboratory data. Read More

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http://dx.doi.org/10.1016/j.path.2017.07.006DOI Listing
December 2017
10 Reads

A fresh look at polymicrobial bloodstream infection in cancer patients.

PLoS One 2017 24;12(10):e0185768. Epub 2017 Oct 24.

Department of Infectious Diseases, Hospital Universitari de Bellvitge, IDIBELL (Institut d´Investigació Biomèdica de Bellvitge), University of Barcelona, Barcelona, Spain.

Objectives: To assess the current incidence, clinical features, risk factors, aetiology, antimicrobial resistance and outcomes of polymicrobial bloodstream infection (PBSI) in patients with cancer.

Methods: All prospectively collected episodes of PBSI in hospitalised patients were compared with episodes of monomicrobial bloodstream infection (MBSI) between 2006 and 2015.

Results: We identified 194 (10. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185768PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655483PMC
November 2017
8 Reads

Daunorubicin 90 mg/m in Acute Myeloid Leukemia Induction: Increased Toxicity in Young Patients.

Clin Lymphoma Myeloma Leuk 2017 08 21;17(8):527-531. Epub 2017 Jun 21.

Hematology Service, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: The combination of an anthracycline and cytosine arabinoside has been the standard induction therapy for acute myeloid leukemia for more than 3 decades. The clinical benefit of intensification of the daunorubicin dose to 90 mg/m has been supported by randomized trials. Based on these promising results, in 2010 we changed our induction protocol of acute myeloid leukemia, increasing the dose of daunorubicin. Read More

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http://dx.doi.org/10.1016/j.clml.2017.06.018DOI Listing
August 2017
9 Reads

Neutropenic enterocolitis (typhlitis) in a pediatric renal transplant patient. A case report and review of the literature.

Pediatr Transplant 2017 Sep 30;21(6). Epub 2017 Jun 30.

Division of Pediatric Nephrology, Department of Pediatrics, Duke University Health System, Durham, NC, USA.

NE (typhlitis) is a potentially life-threatening disease process characterized by bowel wall edema, ulceration, and hemorrhage in an immunosuppressed patient. We report a 15-year-old boy status post deceased donor renal transplantation who presented with fever, abdominal pain, and diarrhea. Laboratory studies revealed neutropenia 5 days prior to admission, and abdominal computed tomography revealed bowel wall thickening in the cecum consistent with NE. Read More

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http://doi.wiley.com/10.1111/petr.13022
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http://dx.doi.org/10.1111/petr.13022DOI Listing
September 2017
12 Reads

Moxifloxacin versus levofloxacin or ciprofloxacin prophylaxis in acute myeloid leukemia patients receiving chemotherapy.

Support Care Cancer 2017 12 28;25(12):3715-3721. Epub 2017 Jun 28.

College of Pharmacy and Health Sciences, Butler University, 4600 Sunset Ave, Indianapolis, IN, 46208, USA.

Purpose: Patients receiving intensive chemotherapy regimens are at high risk for infectious complications due to prolonged neutropenia and hospital stay. Fluoroquinolone antibiotics, mainly levofloxacin and ciprofloxacin, are the mainstay of prophylactic therapy for these patients. There is limited data regarding the utilization of other quinolone antibiotics including moxifloxacin in this setting. Read More

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http://dx.doi.org/10.1007/s00520-017-3797-2DOI Listing
December 2017
7 Reads

spp. and colonization in neutropenic febrile children with cancer.

Germs 2017 Jun 1;7(2):61-72. Epub 2017 Jun 1.

MD, PhD, Department of Pathology (Division of Microbiology), Santa Casa de São Paulo School of Medicine, Rua Dr Cesario Mota Junior 61, São Paulo, SP, Brazil.

Introduction: Febrile neutropenia is one of the most serious treatment-related complications in cancer patients. Susceptible to rapidly progressing infections, which result in prolonged hospitalization and use of broad-spectrum antibiotics, neutropenic patients are subject to colonization by multiresistant agents, which enhances the risk of infections.

Methods: In this study we included samples collected with nasal, oropharyngeal and anal swabs from hospitalized children with febrile neutropenia following chemotherapy, between March 2014 and 2015, aiming to elucidate colonization by and spp. Read More

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http://dx.doi.org/10.18683/germs.2017.1110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466824PMC
June 2017
18 Reads

Ileocaecal valve syndrome after surgery in adult patients: myth or reality?

Colorectal Dis 2017 Aug;19(8):e288-e295

Department of Medical, Surgical and Health Sciences, General Surgery Clinic, University Hospital of Trieste, Trieste, Italy.

Aim: The onset of symptoms after removal of the ileocaecal valve (ICV) may be perceived as an unwanted effect of surgery and induce patients to bring unnecessary litigation against surgeons. The aim of our study is to assess the real impact on the quality of life of patients whose ICV has been surgically removed, using three validated questionnaires.

Method: In patients who had their ICV removed surgically, the Gastrointestinal Quality of life (GIQLI) questionnaire and those used by the European Organization for research and Treatment of Cancer (EORTC) were administered before and after surgery. Read More

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http://dx.doi.org/10.1111/codi.13778DOI Listing
August 2017
3 Reads

Can complications in febrile neutropenia be predicted? Report from a developing country.

Support Care Cancer 2017 11 11;25(11):3523-3528. Epub 2017 Jun 11.

Division of Pediatric Hematology Oncology, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.

Purpose: Febrile neutropenia (FN) is an important cause of morbidity and mortality in children with acute lymphoblastic leukemia (ALL). We aimed to look at complications in febrile neutropenia and to derive a risk model for developing complications from the variables predicting complications.

Methods: Children on treatment for ALL, presenting with FN, were prospectively enrolled over a period of 1 year. Read More

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http://link.springer.com/10.1007/s00520-017-3776-7
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http://dx.doi.org/10.1007/s00520-017-3776-7DOI Listing
November 2017
45 Reads
2.360 Impact Factor

Ultrasonography-driven combination antibiotic therapy with tigecycline significantly increases survival among patients with neutropenic enterocolitis following cytarabine-containing chemotherapy for the remission induction of acute myeloid leukemia.

Cancer Med 2017 Jul 26;6(7):1500-1511. Epub 2017 May 26.

Advanced Biomedical Sciences, Federico II University Medical School, Naples, Italy.

Neutropenic enterocolitis (NEC) is an abdominal infection reported primarily in patients with acute myeloid leukemia (AML) following chemotherapy, especially cytarabine, a notable efficacious cytotoxic agent for AML remission. Specific data regarding the impact of different cytarabine schedules and/or antibacterial regimens for NEC are sparse. The aim of the study was to identify the predictors of outcome within 30 days of NEC onset. Read More

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http://dx.doi.org/10.1002/cam4.1063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504336PMC
July 2017
57 Reads

Nodular typhlocolitis, heterakiasis, and mesenchymal neoplasia in a ring-necked pheasant ( Phasianus colchicus) with immunohistochemical characterization of visceral metastases.

J Vet Diagn Invest 2017 Jul 3;29(4):561-565. Epub 2017 May 3.

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH.

A 9-y-old, male ring-necked pheasant ( Phasianus colchicus) was autopsied following euthanasia because of acute distress, recumbency, and dyspnea. The bird had experienced a protracted period of neuromuscular disease localized to the left sciatic nerve. Gross and histologic examination of the large intestine revealed intramural nodules predominantly comprised of atypical, whorling spindle cells with small cores of granulomatous inflammation centered on cross-sections of immature adult nematodes. Read More

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http://dx.doi.org/10.1177/1040638717707555DOI Listing

Gastrointestinal emergencies in critically ill cancer patients.

J Crit Care 2017 08 24;40:69-75. Epub 2017 Mar 24.

Medical Intensive Care Unit, Saint-Louis University Hospital, AP-HP, Paris, France. Electronic address:

Purpose: To describe gastrointestinal emergencies in cancer patients.

Methods: All cancer patients admitted to the medical ICU of Saint-Louis Hospital for an acute abdominal syndrome during the study period (1997-2011) were included.

Results: A total of 164 patients were included. Read More

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http://dx.doi.org/10.1016/j.jcrc.2017.03.015DOI Listing
August 2017
24 Reads

Infections in Cancer Patients with Solid Tumors: A Review.

Infect Dis Ther 2017 Mar 3;6(1):69-83. Epub 2017 Feb 3.

The Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Solid tumors are much more common than hematologic malignancies. Although severe and prolonged neutropenia is uncommon, several factors increase the risk of infection in patients with solid tumors, and the presence of multiple risk factors in the same patient is not uncommon. These include obstruction (most often caused by progression of the tumor), disruption of natural anatomic barriers such as the skin and mucosal surfaces, and treatment-related factors such as chemotherapy, radiation, diagnostic and/or therapeutic surgical procedures, and the increasing use of medical devices such as various catheters, stents, and prostheses. Read More

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http://dx.doi.org/10.1007/s40121-017-0146-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336421PMC
March 2017
23 Reads