9,120 results match your criteria Neutropenic Enterocolitis
Rev Chilena Infectol 2018 Aug;35(4):448-452
Facultad de Medicina, Universidad de Chile, Chile.
We report a case of a patient with acute lymphoblastic leukemia (ALL), who developed a disseminated infection by Fusarium verticillioides during chemotherapy-induced neutropenia. He was successfully treated only after combination therapy with voriconazole plus amphotericin B deoxycolate was used, but not when these compounds were used in an isolated form. Read More
Rev Chilena Infectol 2018 ;35(3):233-238
Servicio de Infectologia, Hospital de Pediatría Juan P. Garrahan, Argentina.
Introduction: Bacteremia is a frequent complication in children with cancer, which is associated with greater severity, prolonged hospitalization and mortality. Prolonged hospitalization conditions greater morbidity and risk of acquisition of intranosocomial infections.
Aim: To describe risk factors for prolonged hospital length of stay in children with leukemia and bacteremia. Read More
Antimicrob Agents Chemother 2018 Dec 10. Epub 2018 Dec 10.
University of Texas Health Science Center at San Antonio, San Antonio, TX.
is an emerging pathogen associated with significant mortality and often multi-drug resistance. VT-1598, a tetrazole-based fungal CYP51-specific inhibitor, was evaluated and against Susceptibility testing was performed against 100 clinical isolates of by broth microdilution. Neutropenic mice were infected intravenously with , and treatment began 24 hours post-inoculation with vehicle control, oral VT-1598 (5, 15, and 50 mg/kg once daily), oral fluconazole (20 mg/kg once daily), or intraperitoneal caspofungin (10 mg/kg once daily), which continued for 7 days. Read More
Antimicrob Agents Chemother 2018 Dec 10. Epub 2018 Dec 10.
Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.
Background: We present our experience in patients with hematologic malignancy and infection treated with ceftolozane-tazobactam.
Materials/methods: We performed a single-center case-control study including all patients with hematologic malignancy and infection treated with ceftolozane-tazobactam (study group) and compared them with similar patients not treated with ceftolozane-tazobactam (control group) to assess safety and efficacy.
Results: Nineteen cases and 38 controls were analyzed. Read More
Eur J Cancer Care (Engl) 2018 Dec 5:e12974. Epub 2018 Dec 5.
Melbourne School of Health Sciences, The University of Melbourne, Carlton, Victoria, Australia.
Introduction: Recent worldwide advances in cancer therapies have resulted in an increased number of people receiving chemotherapy in ambulatory care settings. In Spain, emergency departments are the single point of entry to acute inpatient services and they play a pivotal role in the management of chemotherapy complications. Little research exists in patterns of emergency department utilisation by oncology patients with chemotherapy-related complications. Read More
Int J Hematol 2018 Dec 3. Epub 2018 Dec 3.
Department of Hematology and Oncology, Marshall University, 1400 Hal Greer Blvd, Huntington, WV, 25701, USA.
Neutropenic enterocolitis mostly affects patients with acute myeloid leukemia (AML) who get treated with intensive chemotherapy which is associated with prolonged neutropenia; its pathogenesis is not well understood and the main factors in this life-threatening condition appear to be neutropenia, mucosal injury and a weakened immune system as a consequence of intensive chemotherapeutic agents. Midostaurin in combination with chemotherapy became the standard of care for FLT3 mutant AML since its approval by the United States Food and Drug Administration (FDA) in April 2017. Anecdotally in our institution, we noticed the common occurrence of neutropenic colitis in three out of three patients who were treated with midostaurin as part of induction chemotherapy for AML. Read More
Blood Adv 2018 Nov;2(Suppl 1):63-66
Peckham Center for Cancer and Blood Disorders, Rady Children's Hospital San Diego, San Diego, CA.
Intern Med J 2018 Dec;48(12):1533-1535
Department of Medicine, Flinders University and Flinders Centre for Innovation in Cancer, Adelaide, South Australia, Australia.
Guidelines suggest that carefully selected patients with neutropenic fever (NF) may be suitable for early discharge on oral antibiotics. Despite these recommendations, many centres manage NF with intravenous antibiotic protocols and inpatient care. We have conducted a retrospective audit of patients with NF, and found that 12 of 40 (30%) patients were eligible for early discharge on oral antibiotics and ambulatory care. Read More
Crit Care 2018 Dec 4;22(1):326. Epub 2018 Dec 4.
Medical-Surgical ICU, Saint-Etienne University Hospital, Avenue Albert Raimond, 42270, Saint-Priest-en-Jarez, France.
Background: The study objective was to assess the influence of neutropenia on outcome of critically ill cancer patients by meta-analysis of individual data. Secondary objectives were to assess the influence of neutropenia on outcome of critically ill patients in prespecified subgroups (according to underlying tumor, period of admission, need for mechanical ventilation and use of granulocyte colony stimulating factor (G-CSF)).
Methods: Data sources were PubMed and the Cochrane database. Read More
World J Clin Cases 2018 Nov;6(14):776-780
Department of General Internal Medicine, Saitama Medical University, Iruma-gun 350-0495, Saitama, Japan.
A 19-year-old female was diagnosed with ulcerative colitis when she presented with persistent melena, and has been treated with 5-aminosalicylic acid for 4 years, with additional azathioprine for 2 years at our hospital. The patient experienced high-grade fevers, chills, and cough five d prior to presenting to the outpatient unit. At first, the patient was suspected to have developed neutropenic fever; however, she was diagnosed with Epstein-Barr virus-associated hemophagocytic syndrome (EB-VAHS) upon fulfilling the diagnostic criteria after bone marrow aspiration. Read More
Rev Esp Quimioter 2018 Nov 30. Epub 2018 Nov 30.
Rodrigo Poves-Alvarez, Anesthesiology and Surgical Critical Care Department Hospital Clínico Universitario de Valladolid Valladolid (Spain).
Objective: The objective of this study was to evaluate the impact of echinocandins and fluconazole) on mortality 7 and 30 days after candidemia onset and overall in-hospital mortality), in patients with candidemia at a Spanish tertiary hospital.
Methods: A retrospective study was conducted that enrolled all non-neutropenic adult patients diagnosed with candidemia at Hospital Clínico Universitario de Valladolid between 2007 and 2016. A total of 179 patients were evaluated, they were divided into two sub-groups: surviving patients (n = 92) and non-surviving patients (n = 87). Read More
Infection 2018 Nov 29. Epub 2018 Nov 29.
Department of Infectious Diseases and Clinical Microbiology, Ege University Faculty of Medicine, Izmir, Turkey.
Purpose: In this multicentre, retrospective, matched cohort study we aimed to evaluate the outcomes of neutropenic fever cases that were treated with daptomycin or a glycopeptide (vancomycin or teicoplanin).
Methods: Data and outcomes of adult (aged > 18-years old) patients with neutropenic fever [(1) without clinical and radiological evidence of pneumonia, (2) who were treated with daptomycin or a glycopeptide (teicoplanin or vancomycin) for any reason and for at least 72 h] were extracted from the hospital databases. Matching was performed with all of the three following criteria: (1) underlying disease, (2) reason for starting daptomycin or glycopeptide (microbiologic evidence vs. Read More
Transfus Med Hemother 2018 Oct 24;45(5):318-322. Epub 2018 Aug 24.
NHS Blood & Transplant/Oxford University Hospitals NHS Foundation Trust, and University of Oxford; Oxford, UK.
Introduction: Granulocyte transfusions are used to either treat or prevent life-threatening infections in neutropenic patients. Current evidence from clinical trials does not support or reject efficacy, nor guide practice.
Methods: A group of investigators have led the efforts to create an online registry to gather information on granulocyte transfusion practices from as broad a range of international settings. Read More
J Infect Chemother 2018 Oct 25. Epub 2018 Oct 25.
Department I of Internal Medicine, Critical Care Medicine, University Hospital of Cologne, Cologne, Germany. Electronic address:
Raoultella planticola is a gram-negative, encapsulated, aerobic bacterium within the Enterobacteriaceae family. It has been primarily described as pathogen in cases with pneumonia and gastrointestinal infections. Here we describe a case of severe pelvic cellulitis in a patient with neutropenia following induction therapy for myeloid sarcoma. Read More
Crit Care Resusc 2018 Dec;20(4):313-319
Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Vic, Australia.
Objectives: There is an increasing incidence of invasive candidal infections in critically ill patients worldwide, which has prompted development of various risk prediction rules, both clinical and microbiological. To date, however, there is a lack of research into how cumulative risk factors over time affect transition to candidaemia. The aim of this study was to investigate the association of risk factor accumulation over time with candidaemia in a cohort of critically ill, non-neutropenic adult patients. Read More
Biol Blood Marrow Transplant 2018 Nov 24. Epub 2018 Nov 24.
Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA; Department of Healthcare Epidemiology, Infection Prevention and Control, University of Pennsylvania, Philadelphia, PA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Objectives: Patients undergoing stem cell transplant (SCT) for the treatment of hematologic malignancy are at increased risk for central line-associated bloodstream infections (CLABSIs). The use of prophylactic antibiotics to prevent CLABSIs in the setting of autologous SCT is of unclear benefit. We aimed to evaluate the impact of levofloxacin prophylaxis on reducing CLABSIs in this high-risk population. Read More
IDCases 2018 13;14:e00469. Epub 2018 Nov 13.
Division of Infection Control and Prevention, Osaka University Hospital, Japan.
species is rarely found to be pathogenic to humans and there are few clinical cases that have been described in the literature. We report a case of bacteremia that involved a 9-year-old Japanese boy who was in a condition of febrile neutropenia caused by chemotherapy for cerebellar medulloblastoma. Conventional phenotyping failed to identify the organism; however, genetic analysis using 16S rDNA sequencing confirmed the pathogen to be . Read More
J Mycol Med 2018 Dec 26;28(4):659-662. Epub 2018 Oct 26.
Department of Clinical Haematology, University Hospital of Dijon, 21000 Dijon, France.
Trichoderma species are saprophytic filamentous fungi that can be found all over the word. These fungi show increasing medical importance as opportunistic human pathogens, particularly in immunocompromised patients. Invasive infections due to Trichoderma are rare and definitive diagnosis is complex to achieve because of the lack of specific diagnosis tools. Read More
J Pharmacol Toxicol Methods 2018 Nov 23;95:27-35. Epub 2018 Nov 23.
National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Introduction: Haemophilus parasuis, one of the major swine pathogens, has at least fifteen different types, all of which have significant economic effects on the global swine industry. The aim of this study was to establish an experimental intraperitoneal infection model for H. parasuis in neutropenic guinea pigs. Read More
Eur J Oncol Nurs 2018 Dec 21;37:12-18. Epub 2018 Oct 21.
University of Sheffield, Weston Park Hospital, Witham Road, Sheffield, S10 2SJ, UK.
Purpose: The primary aim of this study was to examine the value of temperature as a diagnostic and prognostic indicator of infection and sepsis in neutropenic patients. A secondary aim was to gain insight into the presenting symptoms reported by these patients at home or on their initial admission assessment.
Methods: A cohort study was carried out using a case note review of 220 emergency admissions to a regional cancer centre. Read More
Clin Transl Oncol 2018 Nov 23. Epub 2018 Nov 23.
Hematology and Medical Oncology Department, Hospital Universitario Morales Meseguer, IMIB, Avenida Marqués de los Vélez, 30008, Murcia, Spain.
Febrile neutropenia (FN) is a common dose-limiting toxicity of chemotherapy, with a profound impact on the evolution of patients with cancer, due to the potential development of serious complications, mortality, delays, and decrease in treatment intensity. This article seeks to present an updated clinical guideline, with recommendations regarding the diagnosis, prevention, and treatment of febrile neutropenia in adults with solid tumors. The aspects covered include how to properly approach the risk of microbial resistances, epidemiological aspects, considerations about the initial empirical approach adapted to the risk, special situations, and prevention of complications. Read More
J Immunol 2018 Dec 21;201(12):3793-3803. Epub 2018 Nov 21.
Department of Physiology, Semmelweis University School of Medicine, 1094 Budapest, Hungary;
Mouse strains with specific deficiency of given hematopoietic lineages provide invaluable tools for understanding blood cell function in health and disease. Whereas neutrophils are dominant leukocytes in humans and mice, there are no widely useful genetic models of neutrophil deficiency in mice. In this study, we show that myeloid-specific deletion of the Mcl-1 antiapoptotic protein in () mice leads to dramatic reduction of circulating and tissue neutrophil counts without affecting circulating lymphocyte, monocyte, or eosinophil numbers. Read More
Curr Opin Pediatr 2018 Nov 16. Epub 2018 Nov 16.
Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Purpose Of Review: Fever during neutropenia is a common occurrence in children with cancer. A number of studies have recently been performed to refine algorithms regarding initiation, modification, and termination of antimicrobial treatment and are the basis for international pediatric-specific guidelines for the treatment of fever and neutropenia in children with cancer.
Recent Findings: Although hospitalization and prompt initiation of intravenous broad-spectrum antibiotics remains the mainstay in the treatment of febrile neutropenic children with cancer, recent research has addressed a number of questions to optimize the management of these patients. Read More
Front Immunol 2018 6;9:2549. Epub 2018 Nov 6.
Instituto de Carboquímica ICB-CSIC, Zaragoza, Spain.
Pulmonary aspergillosis is a severe infectious disease caused by some members of the genus, that affects immunocompetent as well as immunocompromised patients. Among the different disease forms, Invasive Aspergillosis is the one causing the highest mortality, mainly, although not exclusively, affecting neutropenic patients. This genus is very well known by humans, since different sectors like pharmaceutical or food industry have taken advantage of the biological activity of some molecules synthetized by the fungus, known as secondary metabolites, including statins, antibiotics, fermentative compounds or colorants among others. Read More
Clin J Oncol Nurs 2018 Dec;22(6):611-617
Background: Accurate temperature measurement in patients with cancer is critical. Many patients are neutropenic; therefore, fever represents an oncologic emergency, and, in many cases, it can be the only indication of a life-threatening infection. Although oral thermometers most closely represent true core temperature, patients may have barriers to oral thermometry. Read More
Curr Opin Hematol 2019 Jan;26(1):6-15
Department of Medicine, University of Washington, Seattle, Washington, USA.
Purpose Of Review: Barth syndrome (BTHS) is an X-linked disease characterized by defective remodeling of phospholipid side chains in mitochondrial membranes. Major features include neutropenia, dilated cardiomyopathy, motor delay and proximal myopathy, feeding problems, and constitutional growth delay. We conducted this review of neutropenia in BTHS to aid in the diagnosis of this disease, and to improve understanding of both the consequences of neutropenia and the benefits of treatment with granulocyte colony-stimulating factor (G-CSF). Read More
Med J Armed Forces India 2018 Oct 1;74(4):358-364. Epub 2017 Sep 1.
Consultant, Department of Pathology, Apollo Gleneagles Hospital, Kolkata, India.
Background: is an emerging, opportunistic, pathogenic, zoonotic achlorophyllous green alga, expanding in pathogenicity and host range, causing localized and disseminated infections. This outbreak of algaemia and sepsis in a tertiary care 30-bedded chemotherapy oncology unit is the first human outbreak to the best of our knowledge.
Methods: algaemia was confirmed on consecutive isolation. Read More
Biol Blood Marrow Transplant 2018 Nov 15. Epub 2018 Nov 15.
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Joan and Sanford Weill Cornell Medical College, New York, New York. Electronic address:
In recent years, vancomycin-resistant Enterococcus (VRE) colonization is being increasingly encountered in transplant recipients, and VRE has become one of the leading causes of bacteremia early after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Data are sparse on the effect of empiric VRE therapy for febrile, neutropenic allo-HSCT recipients colonized with VRE. All allo-HSCT recipient age ≥18 years who developed VRE bacteremia (VREB) between 2005 and 2014 were identified and categorized as to whether they received empiric or directed VRE therapy. Read More
J Mycol Med 2018 Nov 13. Epub 2018 Nov 13.
Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900 Ribeirão Preto, 14049-900 São Paulo Brazil. Electronic address:
To study invasive pulmonary Aspergillosis (IPA), we depleted neutrophils in mice using the monoclonal antibody anti-Gr-1/Ly-6G. Immunocompetent and neutropenic mice were infected via intratracheal with conidia of Aspergillus fumigatus clinical isolates, characterized as either higher or lower elastase producers. Neutropenic animals exhibited 100% mortality in 5 days, for both strains, and were observed survival curves overlapped, lungs with angioinvasion, rupture of bronchial and vascular walls, associated with exuberance of conidia filamentation. Read More
Pediatr Infect Dis J 2018 Nov 13. Epub 2018 Nov 13.
Department of Pediatrics, Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands.
A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene. Read More
Clin Infect Dis 2018 Nov;67(suppl_2):S174-S178
Department of Hematology, Shanghai Jiao Tong University-affiliated Shanghai General Hospital, China.
Background: Bacterial infections are very common among patients with hematological diseases. Scant data are available regarding differences in the epidemiology and biological features of bacterial infections in neutropenic and non-neutropenic patients.
Methods: The aim of this survey was to compare the bacterial pathogens in neutropenic and non-neutropenic patients in the same ward during an 8-year period. Read More
Antimicrob Agents Chemother 2018 Nov 12. Epub 2018 Nov 12.
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA
Herein, we evaluated sustainability of humanized exposures of cefiderocol over 72h against pathogens with cefiderocol MICs of 0.5-16 μg/mL in the neutropenic murine thigh model. In , , and displaying MICs 0. Read More
J Antimicrob Chemother 2018 Nov 9. Epub 2018 Nov 9.
J Pak Med Assoc 2018 Nov;68(11):1613-1617
Combined Military Hospital, Rawalpindi (Army Medical Corps), Rawalpindi, Pakistan.
Objective: To observe the duration for normalization of the Total Leucocyte Count (TLC) with adjuvant Granulocyte-Colony Stimulating Factor (G-CSF) treatment in leukopenic neonatal sepsis, and to compare the neutrophilic response to G-CSF in neutropenic vs non-neutropenic subgroups.
Methods: This prospective cohort study was carried out at the Neonatal Intensive Care Unit at Military Hospital Rawalpindi (NICU) from 1st August 2015 to 25th January 2017. Fifty one newborns with sepsis and leucopenia were sampled judgmentally from a population of 5666 admitted to NICU during the study period. Read More
Int J Infect Dis 2018 Nov 3. Epub 2018 Nov 3.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing 100730, China. Electronic address:
Objectives: This study aimed to investigate the distinguishing ability of lymphocyte subtyping for Invasive candidiasis (IC) diagnosis and prognosis in non-neutropenic critically ill patients.
Methods: We assessed the quantitative changes in key parameters of lymphocyte subtyping at the onset of clinical signs of infection in non-neutropenic critically ill patients and their potential influence on diagnosis and outcome of IC. The primary outcome was 28-day mortality. Read More
Am J Dermatopathol 2018 Nov 8. Epub 2018 Nov 8.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL.
Antimicrob Agents Chemother 2018 Nov 5. Epub 2018 Nov 5.
The Medicines Company, San Diego, California, USA.
Vaborbactam is a novel beta-lactamase inhibitor with activity against important beta-lactamases, in particular, serine carbapenemases, and is currently approved in combination with meropenem as Vabomere™ for the treatment of complicated urinary tract infections, including pyelonephritis. This combination is highly active against Gram-negative pathogens, especially KPC-producing, carbapenem-resistant, The objective of these studies was to evaluate vaborbactam pharmacokinetics (PK) and pharmacodynamics (PD) relationships for efficacy in a neutropenic mouse thigh infection model and as well in an in vitro hollow fiber infection model, in combination with a fixed exposure of meropenem using KPC-containing strains of For both models, the meropenem dosage regimen was designed to simulate a 2 g dose administered every eight hours (q8h) by three hour infusion. Vaborbactam dosage regimens were designed to produce a wide range of 24 hour AUCs in the thigh infection model. Read More
J Thorac Oncol 2018 Oct 31. Epub 2018 Oct 31.
Department of Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, United Kingdom; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Electronic address:
Introduction: There is a lack of data on the efficacy and safety of concurrent chemoradiotherapy in elderly, limited-stage, patients with SCLC.
Methods: We compared outcomes of patients 70 years of age or older versus younger patients within the Concurrent Once-daily Versus twice-daily RadioTherapy (CONVERT) trial. Patients were randomized to receive 45 Gy/30 twice-daily fractions/19 days or 66 Gy/33 once-daily fractions/45 days concurrently with platinum-based chemotherapy. Read More
Lancet Haematol 2018 Nov;5(11):e532-e542
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: Haemopoietic stem-cell transplantation (HCT) conditioning regimens that can reduce risk of relapse without increasing non-relapse mortality are needed. We aimed to test the safety of timed-sequential delivery of low-dose versus high-dose myeloablative busulfan in older patients and patients with comorbidities.
Methods: This non-stratified, open-label, randomised phase 2 trial was done at The University of Texas MD Anderson Cancer Center (Houston, TX, USA). Read More
Open Forum Infect Dis 2018 Oct 10;5(10):ofy258. Epub 2018 Oct 10.
Department of Infectious Diseases, University of Utah Health, Salt Lake City, Utah.
Implementation of Biofire FilmArray Blood Culture Identification Multiplex PCR panel (BCID) at a cancer hospital was associated with reduced time to appropriate antimicrobial therapy. Additional reductions were not observed when BCID was coupled with antimicrobial stewardship intervention. Read More
Transfusion 2018 Nov 1. Epub 2018 Nov 1.
Oxford University Hospitals NHS Foundation Trust & Oxford BRC Hematology Theme Oxford, Oxford, United Kingdom.
Background: Patients with prolonged neutropenia caused by chemotherapy or underlying marrow disorders are at risk of invasive bacterial and fungal infections. New treatment options alongside targeted antimicrobial therapy that might improve outcomes include granulocyte transfusions (GTX). To inform the research agenda, a prospective observational cohort study was performed in the Netherlands and United Kingdom. Read More
Int J Clin Pract 2018 Dec 30;72(12):e13275. Epub 2018 Oct 30.
Laboratorio de Investigación Anti Microbiana, Hospital Inmaculada, Grupo HLA SLU Granada, Granada, Spain.
Introduction: Candida species are the leading cause of invasive fungal infections in hospitalised patients and are the fourth most common isolates recovered from patients with bloodstream infection. Few data exist on risk factors for candidemia in non-ICU patients. We performed a population-based case-control study to evaluate the main predictors for candidemia in non-ICU patients. Read More
Antimicrob Agents Chemother 2018 Oct 29. Epub 2018 Oct 29.
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA
Herein we describe the efficacy of human-simulated WCK 5222 (cefepime-zidebactam) exposure against carbapenem-resistant in a neutropenic murine thigh infection model. Five of six isolates examined expressed OXA-23 or OXA-24. WCK 5222, despite showing MICs 16 - 64 mg/L, produced remarkable activity; human-simulated exposure showed a decline in bacterial burden for all isolates [mean reduction -2. Read More
Antimicrob Agents Chemother 2018 Oct 29. Epub 2018 Oct 29.
Merck & Co. Inc., Kenilworth, NJ, USA
Tedizolid phosphate, the prodrug of the active antibiotic tedizolid, is an oxazolidinone for the treatment of acute bacterial skin and skin structure infections. Studies in a mouse thigh infection model demonstrated improved potency and pharmacokinetics-pharmacodynamics (PK/PD) vs linezolid. Subsequent studies showed that the efficacy of tedizolid was enhanced in immune competent (IC) compared with neutropenic (IS) mice, with stasis at clinically relevant doses being achieved only in the presence of granulocytes. Read More
Biomed Pharmacother 2018 Dec 4;108:1303-1312. Epub 2018 Oct 4.
Department of Pharmacology, Nandha College of Pharmacy and Research Institute, Erode 638052, Tamilnadu, India.
Linezolid has a better choice for eradication of methicillin-resistant Staphylococcus aureus (MRSA) infections, but its use is limited because of linezolid-induced hepatotoxicity, myelosuppression, and lactic acidosis. This research elucidated the role of silymarin against hepatoxicity of linezolid therapy in MRSA infected Wistar rats. The rats were rendered neutropenic by an intraperitoneal injection of cyclophosphamide injection. Read More
Zhonghua Xue Ye Xue Za Zhi 2018 Sep;39(9):734-738
Institute of Hematology, Peking University People's Hospital, Beijing 100044, China.
To evaluate the clinical efficacy and safety of decitabine in combination with lower-dose CAG regimen (G-CSF, cytarabine and aclarubicin; D-CAG regimen) in the treatment of myelodysplastic syndromes with excess blasts (MDS-EB) and acute myeloid leukemia with myelodysplasia-related changes (AML-MRC), compared to standard CAG regimen. A total of 42 patients with newly diagnosed MDS-EB and AML-MRC from May 2011 to March 2017 were included in the retrospective study. 21 cases were initially treated with G-CSF for priming, in combination with cytarabine of 10 mg/m(2) q12h for 14 days and aclarubicin of 20 mg/d for 4 days (CAG regimen) and the other 21 cases were initially treated with decitabine of 20 mg/m(2) for 5 days and lower-dose CAG regimen (cytarabine of 10 mg/m(2) q12h for 7 days, aclarubicin of 10 mg/d for 4 days, and G-CSF for priming (D-CAG regimen). Read More
J Ultrasound 2018 Oct 27. Epub 2018 Oct 27.
Department of Radiology-Ospedale del Mare-ASL NA1 Centro-Napoli, Naples, Italy.
Purpose: Typhlitis, also known as neutropenic colitis, is a rare inflammatory condition and a potentially life-threatening disease process that typically involves the cecum. Delay in diagnosis may lead to a fatal prognosis with a death rate of 21-48%. Ultrasound evaluation of right lower quadrant may lead to an accurate and rapid diagnosis. Read More
Transfus Clin Biol 2018 Oct 6. Epub 2018 Oct 6.
Department of Hemato-oncology, Faculty Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, I.P. Pavlova 6, 77520 Olomouc, Czech Republic. Electronic address:
Background: There is no universally accepted opinion on the use of granulocyte transfusions collected using apheresis (GTA) in neutropenic patients and severe infection.
Patients And Methods: The efficacy and safety of GTAs transfused at a single center over 10 years were analyzed retrospectively. GTAs were harvested from voluntary unrelated donors after priming with methylprednisolone using continuous apheresis and hydroxyethylstarch as sedimentation agent. Read More
Cancer 2018 Oct 17. Epub 2018 Oct 17.
Early Phase Trials Unit, Churchill Hospital, University of Oxford, Oxford, United Kingdom.
Background: In the current study, the authors sought to determine the maximum tolerated dose (MTD) of the novel class 1 selective histone deacetylase inhibitor CXD101 in a dose escalation study in patients with advanced solid tumors or recurrent/refractory lymphoma.
Methods: The authors escalated the dose of CXD101 from 1 mg twice daily orally for 5 days in a 21-day cycle (3+3 design).
Results: A total of 39 patients were enrolled, 36 of whom received CXD101. Read More
J Antimicrob Chemother 2018 Oct 15. Epub 2018 Oct 15.
Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
Objectives: The neutropenic murine thigh infection model and a dose-fractionation approach were used to determine the pharmacokinetic/pharmacodynamic (PK/PD) relationship of LYS228, a novel monobactam antibiotic with activity against Enterobacteriaceae including carbapenem-resistant strains.
Methods: Mice (n = 4 per group) were inoculated with Enterobacteriaceae strains via intramuscular injection. Two hours post-bacterial inoculation, treatment with LYS228 was initiated. Read More