63,738 results match your criteria Neutropenia


A phase II clinical study of 13-deoxy, 5-iminodoxorubicin (GPX-150) with metastatic and unresectable soft tissue sarcoma.

Cancer Med 2019 Apr 23. Epub 2019 Apr 23.

Division of Hematology/Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: 13-Deoxy, 5-iminodoxorubicin (GPX-150) is a doxorubicin (DOX) analog synthesized to reduce the formation of reactive oxygen species and the cardiotoxic metabolite, doxorubiciniol, the two pathways that are linked to the irreversible, cumulative dose-dependent cardiotoxicity of DOX. In a preclinical chronic models and a phase I clinical study of GPX-150, no irreversible, cumulative dose-dependent cardiotoxicity was demonstrated. Recent studies suggest that DOX cardiotoxicity may be mediated, at least in part, by the poisoning of topoisomerase IIβ. Read More

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http://dx.doi.org/10.1002/cam4.2136DOI Listing

Toxic Encephalopathy After Relapsed Indolent Non-Hodgkin's Lymphoma Following Abrupt Discontinuation of Idelalisib (ZYDELIG®).

Cureus 2019 Feb 11;11(2):e4043. Epub 2019 Feb 11.

Oncology, Marshall University School of Medicine, Huntington, USA.

Idelalisib is a delta isoform-specific, phosphoinositide 3-kinase (PI3-K) inhibitor. It has been used as a single agent for the treatment of relapsed or refractory small lymphocytic lymphoma (SLL), follicular non-Hodgkin's lymphoma (NHL), and in combination with rituximab for patients with chronic lymphocytic leukemia (CLL). We present a case of a 77-year-old man diagnosed with SLL and was treated with multiple chemotherapeutic regimens in the past. Read More

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http://dx.doi.org/10.7759/cureus.4043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464486PMC
February 2019

Phase 1/2 study of fractionated dose lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 ( Lu-J591) for metastatic castration-resistant prostate cancer.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York.

Background: Prostate cancer is radiosensitive. Prostate-specific membrane antigen (PSMA) is selectively overexpressed on advanced, castration-resistant tumors. Lutetium-177-labeled anti-PSMA monoclonal antibody J591 ( Lu-J591) targets prostate cancer with efficacy and dose-response/toxicity data when delivered as a single dose. Read More

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http://dx.doi.org/10.1002/cncr.32072DOI Listing

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology.

Background: Juvenile systemic lupus erythematosus (JSLE) and adult SLE (ASLE) patients present with different clinical manifestations, but it is unknown if there are differences in their antinuclear autoantibody (ANA) profiles or if staining patterns are associated with specific autoantibodies and clinical manifestations.

Objective: To determine whether distinct types and numbers of ANA-staining patterns are associated with specific autoantibodies and clinical manifestations in JSLE and ASLE patients.

Methods: A retrospective study was performed in Thai children (n = 146) and adults (n = 180) diagnosed with SLE using the Systemic Lupus International Collaborating Clinics classification criteria. Read More

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http://dx.doi.org/10.12932/AP-211218-0465DOI Listing

The impact of age on risk assessment, therapeutic practice and outcome in candidemia.

Infect Dis (Lond) 2019 Apr 23:1-10. Epub 2019 Apr 23.

a Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet , Oslo , Norway.

Background: In Norway, the epidemiological situation of candidemia is followed closely. We have previously demonstrated the highest incidence of candidemia in elderly >65 years of age. However, knowledge of other aspects of this infection is lacking. Read More

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http://dx.doi.org/10.1080/23744235.2019.1595709DOI Listing

Two paternal mosaicism of mutation in ELANE causing severe congenital neutropenia exhibit normal neutrophil morphology and ROS production.

Clin Immunol 2019 Apr 19. Epub 2019 Apr 19.

Chong Qing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Electronic address:

Severe congenital neutropenia caused by ELANE gene mutation is a rare disease. To date, only four families were reported with mosaicism. Here we examined the morphology and function of granulocytes isolated from two patients and their mosaic fathers. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.008DOI Listing

Multicenter retrospective study to evaluate the impact of trabectedin plus pegylated liposomal doxorubicin on the subsequent treatment in women with recurrent, platinum-sensitive ovarian cancer.

Anticancer Drugs 2019 Apr 18. Epub 2019 Apr 18.

Navarra University Clinic Madrid.

Debulking surgery, followed by taxane/platinum-based chemotherapy has traditionally been the first-line treatment for advanced ovarian cancer. However, most patients will experience recurrence afterwards, and receive subsequent lines of therapy. It has been proposed that extending the treatment-free interval of platinum can improve the response to a subsequent platinum-based chemotherapy, and reduce associated toxicities in women with recurrent, platinum-sensitive ovarian cancer. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000794DOI Listing

[Macrophage activation syndrome revealing subcutaneous T-cell lymphoma in a 16-year old adolescent].

Pan Afr Med J 2018 2;31:74. Epub 2018 Oct 2.

Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah, Service de Pédiatrie CHU Hassan II, Fès, Maroc.

Macrophage activation syndrome (MAS) is a multisystemic disorder resulting from an over-activation of the immune system leading to a more or less diffuse macrophagic infiltration into the tussues. Clinical signs including fever, hepatosplenomegaly, adenopathy are associated with abnormal values in laboratory test results (bi or pancytopenia, hepatic cytolysis, elevated LDH levels, coagulopathy) and hemophagocytosis. In children, it can be primary or secondary to several disorders. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.74.14686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457733PMC
October 2018

Mortality caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae bacteremia; a case control study: alert to Enterobacteriaceae strains with high minimum inhibitory concentrations of piperacillin/tazobactam.

Diagn Microbiol Infect Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Infection Control Science, Osaka City University, Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan; Department of Infection Control and Prevention, Osaka City University Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka 545-8586, Japan; Research Center for Infectious Disease Sciences (RCIDs), Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. Electronic address:

This study aimed to assess the prognostic factors of patients with bacteremia due to extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) as well as the antimicrobial susceptibility, particularly to piperacillin/tazobactam (PTZ), among ESBL-PE strains. The medical records of 65 patients with ESBL-PE bacteremia divided into the survivor group (n = 52) and nonsurvivor group (n = 13) were retrospectively reviewed. The male-to-female ratio, age, underlying disease, leukocyte count, C-reactive protein level, and treatment did not differ between the 2 groups. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2019.01.018DOI Listing
January 2019

Work-up for Fever During Neutropenia for Both the Stem Cell Transplant Recipient and the Hematologic Malignancy Patient.

Infect Dis Clin North Am 2019 Jun;33(2):381-397

Division of Infectious Diseases, Vanderbilt University Medical Center, A2200 MCN, 1161 21st Avenue South, Nashville, TN 37232-2605, USA. Electronic address:

Fever is a common complication in patients with underlying neutropenia and is associated with significant mortality in neutropenic patients with acute myelogenous leukemia or hematopoietic cell transplant. Fever may be the only sign of infection and requires further clinical assessment, including a history, a physical examination, and additional laboratory and radiographic testing. National and international guidelines recommend initiation of empiric antimicrobial therapy in patients with fever during neutropenia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915520193000
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http://dx.doi.org/10.1016/j.idc.2019.02.003DOI Listing
June 2019
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Antimicrobial Prophylaxis and Preemptive Approaches for the Prevention of Infections in the Stem Cell Transplant Recipient, with Analogies to the Hematologic Malignancy Patient.

Infect Dis Clin North Am 2019 Jun;33(2):361-380

Division of Infectious Diseases, University Hospital of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva CH-1211, Switzerland. Electronic address:

Infectious complications represent one of the most common causes of morbidity and mortality in allogeneic hematopoietic cell transplant (HCT) recipients. Prophylactic and preemptive treatment strategies against bacterial, fungal, viral, and parasitic pathogens are routinely implemented during high-risk post-HCT periods at most transplant centers. The basic concepts and review of current guidelines of antibiotic prophylaxis and empirical/preemptive antibiotic treatment in allogeneic HCT recipients are reviewed in this article. Read More

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http://dx.doi.org/10.1016/j.idc.2019.02.002DOI Listing
June 2019
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Screening of novel drugs for inhibiting hepatitis E virus replication.

J Virol Methods 2019 Apr 17. Epub 2019 Apr 17.

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi 329-0498, Japan. Electronic address:

Hepatitis E, which is caused by hepatitis E virus (HEV), is generally a self-limiting, acute, and rarely fatal disease. It is sometimes fulminant and lethal, especially during pregnancy. Indeed, it occasionally takes a chronic course in immunocompromised individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934183029
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http://dx.doi.org/10.1016/j.jviromet.2019.04.017DOI Listing
April 2019
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Tumor lysis, adverse events, and dose adjustments in 297 venetoclax treated CLL in routine clinical practice.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Center for CLL, Abramson Cancer Center, University of Pennsylvania

Purpose: Clinical trials of venetoclax reported negligible rates of clinical tumor lysis syndrome (TLS) in patients with chronic lymphocytic leukemia (CLL) when using an extended dose escalation schedule. We aimed to understand TLS prophylaxis, rates of select adverse events (AEs), and impact of dosing modifications in routine clinical practice.

Experimental Design: This retrospective cohort study included 297 CLL venetoclax treated patients outside of clinical trials in academic and community centers. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0361DOI Listing

Lower platelet count with increased density of platelet antigens in granulocyte colony-stimulating factor mobilized peripheral blood stem cell donors.

J Formos Med Assoc 2019 Apr 16. Epub 2019 Apr 16.

Department of Hematology and Oncology, Buddhist Hualien Tzu Chi Hospital, Hualien, Taiwan; Department of Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background/purpose: Granulocyte colony-stimulating factor (G-CSF) is widely used for prophylaxis and treatment of neutropenia in cancer patients and also for peripheral blood stem cells (PBSC) mobilization. The aim of this study is to evaluate the possible changes of platelet surface antigens after G-CSF injection in PBSC donors compared with healthy control.

Methods: Between January 1st and December 31st, 2014, 48 healthy voluntary PBSC donors were eligible for this study. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.04.003DOI Listing

Predictors of mortality in patients infected with carbapenem-resistant Acinetobacter baumannii: A systematic review and meta-analysis.

Am J Infect Control 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) tops the list of threats to human health. Studies exploring predictors of mortality in patients with CRAB infection produced conflicting results.

Methods: A systematic search of the PubMed, Embase, and the Cochrane Library databases was performed from inception to June 2018 to identify studies reporting mortality predictors in patients infected with CRAB. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.003DOI Listing
April 2019
3 Reads

Pixantrone, etoposide, bendamustine, rituximab (P[R]EBEN) as an effective salvage regimen for relapsed/refractory aggressive non-Hodgkin lymphoma-Polish Lymphoma Research Group real-life analysis.

Pharmacol Rep 2019 Feb 6;71(3):473-477. Epub 2019 Feb 6.

Department of Hematology, Jagiellonian University, Kraków, Poland.

Background: Despite a significant improvement in treatment outcomes, 30-40% of aggressive non-Hodgkin lymphomas (NHL) patients are refractory or relapse after the first line therapy. Half of them are not eligible to autologous stem cell transplantation (ASCT) due to failure of platinum-based salvage regimens. Pixantrone is conditionally approved in Europe in patients with R/R aggressive NHL failing at least 2 previous lines of therapy. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.001DOI Listing
February 2019
1 Read
1.928 Impact Factor

Levofloxacin versus cefpodoxime for antibacterial prophylaxis in allogeneic stem cell transplantation.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

The University of Texas MD Anderson Cancer Center.

Background: National guidelines recommend antimicrobial prophylaxis for allogeneic stem cell transplant patients during the pre-engraftment period due to increased infection risk during neutropenia. Fluoroquinolones have demonstrated lower rates of bacteremias and incidence of neutropenic fever, but there is limited evidence in the use of alternative antibacterials such as cefpodoxime.

Objectives: The primary objective of this study is to compare the rates of antibiotic prophylaxis failure between levofloxacin and cefpodoxime in allogeneic stem cell transplant recipients. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.013DOI Listing
April 2019
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Pediatric drug safety signal detection of non-chemotherapy drug-induced neutropenia and agranulocytosis using electronic healthcare records.

Expert Opin Drug Saf 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Clinical Research Center , National Center for Children's Health, Beijing Children's Hospital, Capital Medical University , Beijing , China.

Objectives: This study aimed to develop a procedure to explore the adverse drug reaction signals of drug-induced neutropenia (DIN) or drug-induced agranulocytosis (DIA) in children using an electronic health records (EHRs) database.

Methods: A two-stage design was presented. First, the suspected drugs to induce DIN or DIA were selected. Read More

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http://dx.doi.org/10.1080/14740338.2019.1604682DOI Listing

Colchicine: An Impressive Effect on Posttransplant Capillary Leak Syndrome and Renal Failure.

Pediatrics 2019 Apr 18. Epub 2019 Apr 18.

University of Turin, Turin, Italy; and.

Capillary leak syndrome is a critical condition occasionally occurring posttransplant and is characterized by acute endothelial hyperpermeability leading to systemic protein-rich fluid extravasation and consequent hypovolemia, hypoperfusion, and acute kidney injury. Treatment is merely supportive and is based on osmotic drugs, diuretics, continuous renal replacement therapy, and surgical drainage. However, removal of the underlying inflammatory cause is mandatory to achieve stable resolution. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-2820DOI Listing
April 2019
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Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine.

Korean J Pediatr 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.

Purpose: The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported to be rare. The aim of this study was to investigate the rate and types of hematologic side effects of OXC. Read More

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http://dx.doi.org/10.3345/kjp.2019.00017DOI Listing

Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers: A Phase 2 Clinical Trial.

JAMA Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Medical Oncology, Mayo Clinic, Phoenix, Arizona.

Importance: Administration of gemcitabine-cisplatin, the current standard therapy for advanced biliary tract cancers, results in median progression-free survival and overall survival of 8.0 and 11.7 months, respectively. Read More

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http://dx.doi.org/10.1001/jamaoncol.2019.0270DOI Listing
April 2019
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Early neutropenia on day 8 treated with adjuvant Docetaxel-based chemotherapy in early breast cancer patients: Putative mechanisms within the neutrophil pool system.

Authors:
Yoshihiko Furuya

PLoS One 2019 18;14(4):e0215576. Epub 2019 Apr 18.

Department of Surgery, Saiseikai Osaka Nakatsu Hospital, Osaka, Japan.

Most chemotherapy regimens cause neutropenic nadirs between days 10 and 14, and administration of granulocyte colony-stimulating factor (G-CSF) support relies on this timing. In docetaxel (DOC)-based chemotherapy, the frequency of febrile neutropenia (FN) and the G-CSF dose administered varied greatly between studies. Our study goal was to forecast the necessary dose of G-CSF by comparing day 8 neutropenia with putative changes within the neutrophil pool. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215576PLOS
April 2019
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[Comparation of Clinical Efficacy between Two Regimens of Preexcitation Chemotherapy for MDS-RAEB Patients].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):515-519

Department of Hematology, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China,E-mail:

Objective: To investigate the efficacy and safely of DAC and CAG/HAG preexcitation chemotherapy regimens for the treatment of patients with MDS-RAEB (refractory anemia with excess blasts, RAEB).

Methods: The clinical data of 86 MDS-RAEB patients were analyzed retrospectively from February 2014 to February 2018. According to therapeutic regimem, the 86 patients were divided into 2 groups: group A (41 patients) with DAC preexcitation chemotherapy regimen, and group B (45 patients) with CAG/HAG preexcitation chemotherapy regimen; and the disease control effect, effective treatment course, median survival time and incidence of adverse reactions were compared between these 2 groups. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.033DOI Listing

Risk factors for neutropenia and febrile neutropenia following prophylactic pegfilgrastim.

Asia Pac J Clin Oncol 2019 Apr 17. Epub 2019 Apr 17.

College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.

Aim: Neutropenia is a common side effect of myelosuppressive chemotherapy. Administration of granulocyte colony-stimulating factor is being used for neutropenia prophylaxis, but there are patients who develop neutropenia or febrile neutropenia despite prophylaxis. We attempted to identify potential risk factors for chemotherapy-induced neutropenia in patients with pegfilgrastim prophylaxis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajco.13152
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http://dx.doi.org/10.1111/ajco.13152DOI Listing
April 2019
3 Reads

Predictors of Bloodstream Infection in Patients Presenting With Cardiovascular Implantable Electronic Device Pocket Infection.

Open Forum Infect Dis 2019 Apr 21;6(4):ofz084. Epub 2019 Feb 21.

Division of Infectious Diseases, Mayo Clinic College of Medicine and Science, Rochester Minnesota.

Background: Generator pocket infection is the most frequent presentation of cardiovascular implantable electronic device (CIED) infection. We aim to identify predictors of underlying bloodstream infection (BSI) in patients presenting with CIED pocket infection.

Methods: We retrospectively reviewed all adults with CIED pocket infection cared for at our institution from January 2005 through January 2016. Read More

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http://dx.doi.org/10.1093/ofid/ofz084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456888PMC

Clinical Safety and Efficacy of Secondary Prophylactic Pegylated G-CSF in Advanced Pancreatic Cancer Patients Treated with mFOLFIRINOX: A Single-center Retrospective Study.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Objective Although modified FOLFIRINOX (mFOLFIRINOX, mFFX) is widely used for patients with advanced pancreatic ductal adenocarcinoma (PDAC), maintenance of the standard dose intensity is often difficult due to the high incidence of neutropenic events. Pegylated granulocyte colony-stimulating factor (G-CSF) (Peg G) is a long-lasting G-CSF agent that is applicable for prophylaxis against neutropenic complications. The aim of this study was to assess the clinical safety and efficacy of mFFX combined with secondary prophylaxis using Peg G in advanced PDAC patients. Read More

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http://dx.doi.org/10.2169/internalmedicine.2234-18DOI Listing
April 2019
1 Read
0.967 Impact Factor

Severe rhabdomyolysis related to oxaliplatin adjuvant therapy for colorectal cancer.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Medical Oncology, Hospital de São Francisco Xavier, Lisbon, Lisbon, Portugal.

Colorectal cancer is the third most common cancer in men and the second in women. The standard chemotherapy regiment in stage III colon cancer is based in oxaliplatin. The most common side effects include neutropenia, peripheral neuropathy, vomiting and diarrhoea. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22867
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http://dx.doi.org/10.1136/bcr-2018-228673DOI Listing
April 2019
2 Reads

Rates, Predictors and Mortality of Community-Onset Bloodstream Infections due to Pseudomonas aeruginosa: Systematic Review and Meta-Analysis.

Clin Microbiol Infect 2019 Apr 14. Epub 2019 Apr 14.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena / Departamento de Medicina, Universidad de Sevilla / Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain.

Background: Pseudomonas aeruginosa is mostly a nosocomial pathogen affecting predisposed patients. However, community-onset bloodstream infections (CO-BSI) caused by this organism are not exceptional.

Objectives: To assess the predisposing factors for CO-BSI due to P. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.005DOI Listing
April 2019
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Efficacy and toxicity of mustargen, vincristine, procarbazine and prednisone (MOPP) for the treatment of relapsed or resistant lymphoma in cats.

J Feline Med Surg 2019 Apr 17:1098612X19841916. Epub 2019 Apr 17.

5 Mount Laurel Animal Hospital, Mount Laurel, NJ, USA.

Objectives: The aims of this study were to evaluate the safety of mustargen, vincristine, procarbazine and prednisone (MOPP) chemotherapy in the treatment of relapsed or refractory feline lymphoma, and to determine the overall response rate and median remission time with this protocol.

Methods: The medical records of 38 cats with relapsed or refractory lymphoma treated with MOPP chemotherapy at three institutions (University of Pennsylvania, the Animal Medical Center, and VCA Western Veterinary Specialist and Emergency Centre) were examined. Information evaluated included patient signalment, feline immunodeficiency virus/feline leukemia virus status, anatomic location(s) of lymphoma, prior protocols (type and number), MOPP doses, MOPP response, remission duration, hematologic and biochemical parameters, and owner-reported adverse effects. Read More

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http://dx.doi.org/10.1177/1098612X19841916DOI Listing
April 2019
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Combination chemotherapy with gemcitabine and nab-paclitaxel for a metastatic pancreatic ductal adenocarcinoma patient undergoing hemodialysis.

Clin J Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology Division, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.

In cancer patients, impairment of kidney function is not uncommon. Recently, the efficacy of the combination of gemcitabine and nab-paclitaxel for pancreatic ductal adenocarcinoma (PDAC) patients has been reported, however, there is no recommendation for dose and administration to patients undergoing hemodialysis (HD). A 66-year-old man began receiving HD for chronic renal failure 4 years previously. Read More

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http://dx.doi.org/10.1007/s12328-019-00976-wDOI Listing
April 2019
1 Read

Patient factors and their impact on neutropenic events: a systematic review and meta-analysis.

Support Care Cancer 2019 Apr 16. Epub 2019 Apr 16.

UCLH-UCL Centre for Medicines Optimisation Research and Education, UCL School of Pharmacy, 29-39, Brunswick Square, London, WC1N 1AX, UK.

Background: Neutropenia is associated with an increased risk of mortality and hospitalisation. Strategies, including the prescribing of colony-stimulating growth factors (CSFs), are adopted when a high risk (> 20%) of neutropenic complications are seen in the clinical trial setting. With a diverse treatment population that may differ from the patient groups recruited to studies, appropriate prescribing decisions by clinicians are essential. Read More

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http://link.springer.com/10.1007/s00520-019-04773-6
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http://dx.doi.org/10.1007/s00520-019-04773-6DOI Listing
April 2019
2 Reads

Febrile neutropenia-related care and associated costs in elderly patients with breast cancer, lung cancer, or non-Hodgkin lymphoma.

Support Care Cancer 2019 Apr 15. Epub 2019 Apr 15.

Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, 91320, USA.

Purpose: Limited information is available regarding elderly patients experiencing febrile neutropenia (FN). This study evaluated FN-related care among elderly cancer patients who received high/intermediate FN-risk chemotherapy and experienced ≥ 1 FN episodes.

Methods: We used Medicare data to identify patients aged ≥ 66 years who initiated high/intermediate FN-risk chemotherapy between 1 January 2008 and 31 August 2015 to treat breast cancer (BC), lung cancer (LC), or non-Hodgkin lymphoma (NHL) and had ≥ 1 FN episodes. Read More

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http://dx.doi.org/10.1007/s00520-019-04795-0DOI Listing
April 2019
1 Read

Outpatient Parenteral Antimicrobial Therapy in Children.

Curr Infect Dis Rep 2019 Apr 16;21(5):17. Epub 2019 Apr 16.

Department of Paediatric Infectious Diseases & Immunology, Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Mailpoint 43, Tremona Road, Southampton, SO16 6YD, UK.

Purpose Of Review: Over recent years, there has been a marked increase in the number of centres delivering paediatric outpatient parenteral antimicrobial therapy (pOPAT). Various factors have fuelled this drive, including the significant economic pressures faced by high-income countries to contain the cost of healthcare, resulting in a significant reduction of in-patient beds over the past 20 years. It is essential that pOPAT services have formal clinical governance structures in place to ensure the safe and effective management of children being ambulated on intravenous antibiotics. Read More

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http://link.springer.com/10.1007/s11908-019-0669-6
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http://dx.doi.org/10.1007/s11908-019-0669-6DOI Listing
April 2019
2 Reads

A single-arm phase II trial of weekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) monotherapy after standard of chemotherapy for previously treated advanced non-small cell lung cancer.

Cancer Chemother Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Centre, Komagome Hospital, Honkomagome 3-18-22, Bunkyo, Tokyo, 113-0021, Japan.

Background: Few studies have investigated the clinical efficacy of third- and later-line of chemotherapy after standard chemotherapy for previously treated advanced non-small cell lung cancer (NSCLC). We prospectively evaluated the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) following standard chemotherapies for previously treated advanced NSCLC.

Methods: The eligible patients having adequate organ functions with performance status 0-2 were enrolled after completing standard chemotherapy. Read More

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http://dx.doi.org/10.1007/s00280-019-03843-0DOI Listing
April 2019
1 Read

Weekly alternate intensive regimen FIrB/FOx in metastatic colorectal cancer patients: an update from clinical practice.

Onco Targets Ther 2019 25;12:2159-2170. Epub 2019 Mar 25.

Medical Oncology, St Salvatore Hospital, University of L'Aquila, L'Aquila, Italy,

Background: Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting interesting results in terms of received dose intensities (rDIs) and safety.

Methods: We reported a retrospective update of 85 patients treated with FIrB/FOx, an intensive regimen of 5-fluorouracil, bevacizumab, and weekly alternate irinotecan and oxaliplatin, to confirm its feasibility in "real life". Read More

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http://dx.doi.org/10.2147/OTT.S194745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438145PMC
March 2019
1 Read

Is hospital-acquired pneumonia different in transplant recipients?

Clin Microbiol Infect 2019 Apr 12. Epub 2019 Apr 12.

Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain; REIPI (Spanish Network for Research in Infectious Disease), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background: Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are serious complications in transplant patients.

Objectives: The aim of this review is to summarize the evidence regarding nosocomial pneumonia in transplant recipients, including HAP in non-ventilated patients and VAP, and to identify future directions for improvement.

Sources: A comprehensive literature search in the PubMed/MEDLINE database was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193015
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http://dx.doi.org/10.1016/j.cmi.2019.04.003DOI Listing
April 2019
3 Reads

Development of a Clinical Prediction Model for Central Line-Associated Bloodstream Infection in Children Presenting to the Emergency Department.

Pediatr Emerg Care 2019 Apr 11. Epub 2019 Apr 11.

†University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objective: The majority of the children with a central line who present to the emergency department with fever or other signs of bacteremia do not have a central line-associated bloodstream infection (CLABSI). Our objective was to develop a clinical prediction model for CLABSI among this group of children in order to ultimately limit unnecessary hospital admissions and antibiotic use.

Methods: We performed a nested case-control study of children with a central line who presented to the emergency department of an urban, tertiary care children's hospital between January 2010 and March 2015 and were evaluated for CLABSI with a blood culture. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001835DOI Listing
April 2019
2 Reads

Efficacy and Safety of Once-Weekly versus Twice-Weekly Bortezomib in Patients with Hematologic Malignancies: A Meta-analysis with Trial Sequential Analysis.

Pharmacotherapy 2019 Apr 15. Epub 2019 Apr 15.

Department of Hematology, First People's Hospital of Changde City, Changde, Hunan, PR China.

Study Objective: To compare the efficacy and safety of once-weekly and twice-weekly bortezomib therapy in patients with hematologic malignancies.

Design: Meta-analysis of 13 clinical or randomized controlled trials, with trial sequential analysis (TSA).

Patients: A total of 1567 patients with hematologic malignancies who received either once-weekly or twice-weekly bortezomib therapy. Read More

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http://dx.doi.org/10.1002/phar.2267DOI Listing
April 2019
2 Reads

Use of mean platelet volume in the assessment of intrauterine infection in newborns with combined thrombocytopenia and leukopenia at birth.

J Matern Fetal Neonatal Med 2019 Apr 14:1-161. Epub 2019 Apr 14.

a Department of Pediatrics , University of Kansas Medical Center , Kansas City , Kansas , USA.

Objective: Intrauterine stress can be reflected on hematological disturbance at birth. Thrombocytopenia and leukopenia may be a result of exposure to maternal hypertensive disorders but may also indicate fetal inflammatory response to intrauterine infection, prompting empiric antibiotics use during the initial assessment after birth. Emerging data suggest long-term adverse health outcomes associated with antibiotics exposure early in life. Read More

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http://dx.doi.org/10.1080/14767058.2019.1608174DOI Listing
April 2019
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Catheter-related bloodstream infection by Microbacterium paraoxydans in a pediatric patient with B-cell precursor acute lymphocytic leukemia: A case report and review of literature on Microbacterium bacteremia.

J Infect Chemother 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatric Hematology and Oncology, Japanese Red Cross Narita Hospital, Narita, Chiba, Japan.

Microbacterium species are coryneform gram-positive rods that are widely distributed in the environment and have been recently recognized as rare pathogens in humans. However, information about the epidemiologic and clinical characteristics of Microbacterium species is scarce. We herein reported an 11-year-old girl with acute leukemia who was found to have catheter-related bloodstream infection in her neutropenic phase. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.03.013DOI Listing
April 2019
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Bendamustine for patients with indolent B cell lymphoproliferative malignancies including chronic lymphocytic leukaemia - an updated meta-analysis.

Br J Haematol 2019 Apr 13. Epub 2019 Apr 13.

Tel Aviv University, Tel Aviv.

The question of which chemotherapy induction provides the best results for indolent lymphoma patients is yet unanswered. Different regimens have been compared, none of which has been shown to improve overall survival. The use of bendamustine is growing. Read More

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http://dx.doi.org/10.1111/bjh.15901DOI Listing
April 2019
3 Reads

A Pilot Study of Liposomal Doxorubicin Combined with Bevacizumab followed by Bevacizumab Monotherapy in Patients with Advanced Kaposi Sarcoma.

Clin Cancer Res 2019 Apr 12. Epub 2019 Apr 12.

HIV and AIDS Malignancy branch, CCR/NCI/NIH.

Purpose: Vascular endothelial growth factor A (VEGF-A) is important in the pathogenesis of Kaposi sarcoma (KS), and bevacizumab has response rate of 31%. We explored the combination of bevacizumab with liposomal doxorubicin in patients with KS.

Experimental Design: KS patients requiring systemic therapy were enrolled in one of two cohorts. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3528DOI Listing
April 2019
2 Reads

Intravenous and Tablet Formulation of Posaconazole in Antifungal Therapy and Prophylaxis: A Retrospective, non-Interventional, Multicenter Analysis of Hemato-Oncological Patients Treated in Tertiary-Care Hospitals.

Int J Infect Dis 2019 Apr 9. Epub 2019 Apr 9.

University Hospital of Cologne, Department I of Internal Medicine, Cologne, Germany; German Center for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany. Electronic address:

Objectives: Novel formulations (gastro-resistant table and intravenous solution) of posaconazole (POS) have been approved in prophylaxis and therapy of invasive fungal diseases (IFDs). Study aim was to analyze treatment strategies and clinical effectiveness.

Methods: We set up a web-based registry on www. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.006DOI Listing
April 2019
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Single center experience on efficacy and safety of Aprepitant for preventing chemotherapy-induced nausea and vomiting (CINV) in pediatric Hodgkin Lymphoma.

PLoS One 2019 12;14(4):e0215295. Epub 2019 Apr 12.

Department of Pediatric Hemato-Oncology, Santobono-Pausilipon Hospital, Naples, Italy.

Chemotherapy-induced nausea and vomiting (CINV) is a distressing treatment side-effect that could negatively affect children's quality of life (QoL). Different scoring systems for CINV were applied and different antiemetic drugs were used; however, few studies have been performed in children undergoing chemotherapy with Aprepitant. Herein, we report a pediatric experience on efficacy and safety of Aprepitant as part of triple antiemetic prophylaxis, in a cohort of thirty-two children and adolescents with Hodgkin Lymphoma (HL), treated with moderate/highly emetogenic chemotherapy (MEC/HEC) regimens in a single Hemato-Oncology Institution. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215295PLOS
April 2019
3 Reads

Hematological parameters in largemouth bass ( with formalin-preservation: comparison between wild tournament-caught and captive-raised fish.

PeerJ 2019 4;7:e6669. Epub 2019 Apr 4.

Department of Clinical Sciences, North Carolina State University, Raleigh, NC, United States of America.

Background: Largemouth bass () are an economically important freshwater fish species that have been investigated for both the short and long-term effects of stress, secondary to angling. Limited data has been published on the hematological parameters of this species and blood sample stability is a notable limitation of hematologic field studies. A relatively novel technique using 10% neutral buffered formalin preserves heparinized whole blood and maintains blood cell stability beyond one month in striped bass. Read More

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http://dx.doi.org/10.7717/peerj.6669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451833PMC
April 2019
1 Read

Invasive fungal consecutive infections in a patient with acute myeloid leukaemia.

Niger J Clin Pract 2019 Apr;22(4):582-584

Department of Infectious Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

A woman with AML who became febrile and neutropenic after chemotherapy. At the first, Aspergillus was isolated from a sinus biopsy. After 4 weeks, while she was taking voriconazole, another episode of fever combined with dry coughs was detected. Read More

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http://dx.doi.org/10.4103/njcp.njcp_359_17DOI Listing
April 2019
2 Reads

Prognostic value of neutrophil-to-lymphocyte ratio in castration resistant prostate cancer: Single-centre study of Nigerian men.

Niger J Clin Pract 2019 Apr;22(4):511-515

Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Nigeria.

Background: Elevated neutrophil-to-lymphocyte ratio (NLR) has been suggested to be a useful prognosticator of overall survival (OS) in several cancers including castration resistant prostate cancer. However, its utility in black populations known to have benign ethnic neutropenia is unknown. We evaluated the prognostic value of NLR in Nigerian men with CRPC in terms of OS. Read More

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http://www.njcponline.com/text.asp?2019/22/4/511/255924
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http://dx.doi.org/10.4103/njcp.njcp_382_18DOI Listing
April 2019
4 Reads

Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial.

Lancet Oncol 2019 Apr 8. Epub 2019 Apr 8.

Primary Children's Hospital, Salt Lake City, UT, USA.

Background: Hepatoblastoma treatment with curative intent requires surgical resection, but only about a third of newly diagnosed patients with hepatoblastoma have resectable disease at diagnosis. Patients who have upfront resection typically receive a total of 4-6 cycles of adjuvant chemotherapy post-surgery, with the combination of cisplatin, fluorouracil, and vincristine. We aimed to investigate whether event-free survival in children with hepatoblastoma who had complete resection at diagnosis could be maintained with two cycles of adjuvant chemotherapy. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30895-7DOI Listing
April 2019
2 Reads

Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial.

Lancet Oncol 2019 Apr 8. Epub 2019 Apr 8.

Iwate Medical University School of Medicine, Morioka, Japan. Electronic address:

Background: Resistance to first-generation or second-generation EGFR tyrosine kinase inhibitor (TKI) monotherapy develops in almost half of patients with EGFR-positive non-small-cell lung cancer (NSCLC) after 1 year of treatment. The JO25567 phase 2 trial comparing erlotinib plus bevacizumab combination therapy with erlotinib monotherapy established the activity and manageable toxicity of erlotinib plus bevacizumab in patients with NSCLC. We did a phase 3 trial to validate the results of the JO25567 study and report here the results from the preplanned interim analysis. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30035-XDOI Listing
April 2019
3 Reads

Genotyping of human neutrophil antigens 1, 3, 4 and 5 using a novel multiplex polymerase chain reaction.

Transfus Med 2019 Apr;29(2):110-115

Institute for Transfusion Medicine Dessau, Red Cross Blood Transfusion Service NSTOB, Dessau, Germany.

Objectives: Our study aimed to establish a novel multiplex polymerase chain reaction (PCR) for rapid simultaneous detection of all relevant human neutrophil antigen (HNA)-1, -3, -4 and -5 alleles.

Background: Granulocyte-reactive antibodies are involved in several diseases, such as neonatal alloimmune neutropenia, autoimmune neutropenia and transfusion-related acute lung injury. A panel of well-defined test granulocytes is required for diagnostic antibody detection and prospective blood donor screening. Read More

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http://dx.doi.org/10.1111/tme.12594DOI Listing
April 2019
2 Reads