52,189 results match your criteria Neurosurgical Focus [Journal]


Visualization technologies for 5-ALA-based fluorescence-guided surgeries.

J Neurooncol 2018 Dec 15. Epub 2018 Dec 15.

Department of Mechanical Engineering, University of Washington, Seattle, WA, 98195, USA.

Introduction: 5-ALA-based fluorescence-guided surgery has been shown to be a safe and effective method to improve intraoperative visualization and resection of malignant gliomas. However, it remains ineffective in guiding the resection of lower-grade, non-enhancing, and deep-seated tumors, mainly because these tumors do not produce detectable fluorescence with conventional visualization technologies, namely, wide-field (WF) surgical microscopy.

Methods: We describe some of the main factors that limit the sensitivity and accuracy of conventional WF surgical microscopy, and then provide a survey of commercial and research prototypes being developed to address these challenges, along with their principles, advantages and disadvantages, as well as the current status of clinical translation for each technology. Read More

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December 2018

Cranioplasties following craniectomies in children-a multicenter, retrospective cohort study.

Childs Nerv Syst 2018 Dec 15. Epub 2018 Dec 15.

Department of Neurosurgery, Division of Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, room G03.124, 3484 CX, Utrecht, The Netherlands.

Objective: Complications following pediatric cranioplasty after craniectomy with either autologous bone flaps or cranial implants are reported to be common, particularly bone flap resorption. However, only sparse data are available regarding cranioplasty strategies, complications, and outcomes. This manuscript describes a Canadian-Dutch multicenter pediatric cohort study with autografts and cranial implant cranioplasties following craniectomies for a variety of indications. Read More

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December 2018

Topical vancomycin for neurosurgery wound prophylaxis: an interim report of a randomized clinical trial on drug safety in a diverse neurosurgical population.

Authors:

J Neurosurg 2018 Dec 14:1-8. Epub 2018 Dec 14.

OBJECTIVEPostoperative surgical site infections (SSIs) in neurosurgical patients carry a significant risk of increased morbidity and mortality. With SSIs accounting for approximately 20% of nosocomial infections and costing approximately $1.6 billion USD annually, there is a need for additional prophylaxis to improve current standards of care. Read More

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December 2018
1 Read

Incidence of the initiation of comfort care immediately following emergent neurosurgical and endovascular procedures.

Authors:

J Neurosurg 2018 Dec 14:1-9. Epub 2018 Dec 14.

OBJECTIVEIt is unknown what proportion of patients who undergo emergent neurosurgical procedures initiate comfort care (CC) measures shortly after the operation. The purpose of the present study was to analyze the proportion and predictive factors of patients who initiated CC measures within the same hospital admission after undergoing emergent neurosurgery.METHODSThis retrospective cohort study included all adult patients who underwent emergent neurosurgical and endovascular procedures at a single center between 2009 and 2014. Read More

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December 2018

The caroticoclinoid foramen in fetal and infantile orbitosphenoid, presphenoid, and sphenoid bones: developmental and neurosurgical considerations.

Authors:

J Neurosurg Pediatr 2018 Dec 14:1-7. Epub 2018 Dec 14.

OBJECTIVEThe presence of a caroticoclinoid foramen may increase the likelihood of adverse neurosurgical events. Despite the clinical importance of the caroticoclinoid foramen, its study has been mostly limited to adult populations. Therefore, the object of this study was to describe the prevalence, morphology, and development of the caroticoclinoid foramen among varied sexes and races in early life. Read More

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December 2018

Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: Relationship between the electrode trajectory and cognitive decline.

Parkinsonism Relat Disord 2018 Dec 8. Epub 2018 Dec 8.

Department of Psychology, University of Turin, Via Verdi, 8 - 10124, Turin, Italy.

Introduction: It remains to be clarified whether penetration of the caudate nucleus increases the risk of cognitive decline in patients with Parkinson's disease (PD) undergoing deep brain stimulation (DBS) of the subthalamic nucleus (STN).

Methods: A retrospective analysis of pre/postoperative neuropsychological changes was performed with 46 consecutive patients with PD who underwent DBS of the STN. In particular, to evaluate the possible relationship between cognitive changes and DBS lead trajectories, repeated-measures ANCOVAs were conducted to analyze the effects of group (23 patients with vs 23 patients without penetration of the caudate nucleus) and time (T0 vs T1) for each neuropsychological test. Read More

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December 2018

Colistin and polymyxin B for treatment of nosocomial infections in intensive care unit patients: pharmacoeconomic analysis.

Int J Clin Pharm 2018 Dec 15. Epub 2018 Dec 15.

Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Cândido Portinari 200, 13083-871, Campinas, SP, Brazil.

Background The emergence and rapid spread of multidrug-resistant gram-negative bacteria related to nosocomial infections is a growing worldwide problem, and polymyxins have become important due to the lack of new antibiotics. Objectives To evaluate the outcomes and pharmacoeconomic impact of using colistin and polymyxin B to treat nosocomial infections. Setting Neurosurgical, cardiovascular, or transplantation intensive care unit (ICU) at the Clinical Hospital of the University of Campinas (São Paulo, Brazil). Read More

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December 2018

Systematic review of clinician awareness of mycotoxin impact in neural tube defects and best practices for pediatric neurosurgeons: implications for public health and policy.

Childs Nerv Syst 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, Baylor College of Medicine; Division of Pediatric Neurosurgery, Texas Children's Hospital, 6701 Fannin St., Ste. 1230, Houston, TX, 77030, USA.

Purpose: In lower-income populations, high rates of neural tube defects (NTDs) are a concern. Nutritional folate deficiencies and mycotoxins in contaminated food supplies increase risk of NTDs. As physicians in public health and involved in the care of children with NTDs, pediatric neurosurgeons have an interest in the treatment and prevention of NTDs. Read More

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December 2018
1 Read

Understanding cauda equina syndrome: protocol for a UK multicentre prospective observational cohort study.

BMJ Open 2018 Dec 14;8(12):e025230. Epub 2018 Dec 14.

Department for Clinical Neurosciences, Western General Hospital, Edinburgh, UK.

Introduction: Cauda equina syndrome (CES) is a potentially devastating condition caused by compression of the cauda equina nerve roots. This can result in bowel, bladder and sexual dysfunction plus lower limb weakness, numbness and pain. CES occurs infrequently, but has serious potential morbidity and medicolegal consequences. Read More

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December 2018

Neonatal orbital swelling due to intracranial teratoma.

Arch Dis Child Fetal Neonatal Ed 2018 Dec 14. Epub 2018 Dec 14.

Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore, Singapore.

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December 2018

Increased detection of thromboembolic events in neurosurgical patients after updating the perioperative thromboprophylaxis protocol.

Neurocirugia (Astur) 2018 Dec 11. Epub 2018 Dec 11.

Sección de Neuroanestesia, Servicio de Anestesiología y Reanimación, Hospital Clínic de Barcelona, Barcelona, España.

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December 2018

Commentary: Neurosurgical Coverage for Emergency and Trauma Call.

Authors:
Aziz S Alali

Neurosurgery 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurological Surgery, University of Washington, Seattle, Washington.

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December 2018
2 Reads

PREDICTION ALGORITHM OF THE CAT SPINAL SEGMENTS LENGTHS AND POSITIONS IN RELATION TO THE VERTEBRAE.

Anat Rec (Hoboken) 2018 Dec 12. Epub 2018 Dec 12.

Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, Saint-Petersburg, 199034, Russia.

Detailed knowledge of the topographic organization and precise access to the spinal cord segments is crucial for the neurosurgical manipulations as well as in vivo neurophysiological investigations of the spinal networks involved in sensorimotor and visceral functions. Because of high individual variability, accurate identification of particular portion of the lumbosacral enlargement is normally possible only during postmortem dissection. Yet, it is often necessary to determine the precise location of spinal segments prior to in vivo investigation, targeting spinal cord manipulations, neurointerface implantations, and neuronal activity recordings. Read More

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December 2018
1 Read

Effects of Multiple Waveforms on Patient Preferences and Clinical Outcomes in Patients Treated With Spinal Cord Stimulation for Leg and/or Back Pain.

Neuromodulation 2018 Dec 11. Epub 2018 Dec 11.

Neurosurgical Clinic Varese Regional Hospital, Varese, Italy.

Objectives: We present the results of a prospective, randomized, crossover, single-blind, study in which each patient is in control of himself. The aim was to evaluate subperception-based (SP-SCS) waveforms in previously implanted spinal cord stimulation (SCS) patients with leg and/or back pain due to failed back surgery syndrome, who experienced only paresthesia-based stimulation (PB-SCS). Patients with PB-SCS experience in SCS was 4. Read More

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December 2018

Correction to: Intracranial foreign material granuloma after neurosurgical procedures.

Acta Neurochir (Wien) 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hanover, Germany.

Incorrect title of the article. Read More

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December 2018
1 Read

Regular medications prescribed to elderly neurosurgical inpatients and the impact of hospitalization on potentially inappropriate medications.

J Rural Med 2018 Nov 29;13(2):97-104. Epub 2018 Nov 29.

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Japan.

This study aimed to evaluate the regular medications prescribed to elderly neurosurgical inpatients in community hospitals in Japan. Elderly patients (aged ≥ 65 years) who had been admitted to neurosurgery departments from April 2015 to March 2017 were enrolled in this study. We collected data on regular medications at the time of admission and discharge. Read More

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November 2018

MRI Abnormalities Predominate in the Bottom Part of the Sulcus with Type II Focal Cortical Dysplasia: A Quantitative Study.

AJNR Am J Neuroradiol 2018 Dec 13. Epub 2018 Dec 13.

From the Departments of Neurosurgery (Z.L., X.W., K.Z., J.Z.)

Background And Purpose: Type II focal cortical dysplasia is a common histopathological substrate in focal epilepsy. This study explored the spatial distribution of abnormal findings on MR imaging across the sulcus with type II focal cortical dysplasia using quantitative MR imaging postprocessing techniques.

Materials And Methods: The morphometric analysis program and normalized FLAIR signal intensity analysis were applied to retrospectively analyze the MR imaging data of 58 patients with histopathologically confirmed type II focal cortical dysplasia. Read More

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December 2018

Universal staphylococcal decolonization for elective surgeries: The patient perspective.

Am J Infect Control 2018 Dec 11. Epub 2018 Dec 11.

Virginia Commonwealth University Health System, Richmond, VA.

Background: Staphylococcal decolonization decreases the risk of Staphylococcus aureus surgical site infection. This study evaluates patient perceptions and barriers to a universal Staphylococcal decolonization (USD) protocol.

Methods: In October 2013, a protocol for the decolonization of Staphylococcal aureus in elective orthopedic, neurosurgical, and cardiac surgeries was implemented in an effort to further decrease post-operative infections rates. Read More

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December 2018
2.206 Impact Factor

Aneurysm rebleeding before therapy: a predictable disaster?

Authors:

J Neurosurg 2018 Nov 1:1-8. Epub 2018 Nov 1.

OBJECTIVECurrent guidelines for subarachnoid hemorrhage (SAH) include early aneurysm treatment within 72 hours after ictus. However, aneurysm rebleeding remains a crucial complication of SAH. The aim of this study was to identify independent predictors allowing early stratification of SAH patients for rebleeding risk. Read More

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November 2018

Effective accuracy of stereoelectroencephalography: robotic 3D versus Talairach orthogonal approaches.

Authors:

J Neurosurg 2018 Dec 1:1-9. Epub 2018 Dec 1.

OBJECTIVEStereoelectroencephalography (SEEG) was first developed in the 1950s by Jean Talairach using 2D angiography and a frame-based, orthogonal approach through a metallic grid. Since then, various other frame-based and frameless techniques have been described. In this study the authors sought to compare the traditional orthogonal Talairach 2D angiographic approach with a frame-based 3D robotic procedure that included 3D angiographic interoperative imaging guidance. Read More

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December 2018

The impact of the reserve military neurosurgeon: practice, community, and service.

Authors:

Neurosurg Focus 2018 Dec;45(6):E14

OBJECTIVEPapers from 2002 to 2017 have highlighted consistent unique socioeconomic challenges and opportunities facing military neurosurgeons. Here, the authors focus on the reserve military neurosurgeon who carries the dual mission of both civilian and military responsibilities.METHODSSurvey solicitation of current active duty and reserve military neurosurgeons was performed in conjunction with the AANS/CNS Joint Committee of Military Neurosurgeons and the Council of State Neurosurgical Societies. Read More

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December 2018

Elective neurosurgical humanitarian care in a deployed setting.

Authors:

Neurosurg Focus 2018 Dec;45(6):E8

OBJECTIVEActive-duty neurosurgical coverage has been provided at Bagram Air Force Base in Afghanistan since 2007. Early operative logs were reflective of a large number of surgical procedures performed to treat battlefield injuries. However, with maturation of the war effort, the number of operations for battlefield injuries has decreased with time. Read More

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December 2018
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Spine surgery in the International Security Assistance Force Role 3 combat support hospital in Mazar-e-Sharif, northern Afghanistan, 2007-2014.

Authors:

Neurosurg Focus 2018 Dec;45(6):E13

OBJECTIVESince 2007, a continuous neurosurgery emergency service has been available in the International Security Assistance Force (ISAF) field hospital in Mazar-e-Sharif (MeS), Afghanistan. The object of this study was to assess the number and range of surgical procedures performed on the spine in the period from 2007 to 2014.METHODSThis is a retrospective analysis of the annual neurosurgical caseload statistics from July 2007 to October 2014 (92 months). Read More

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December 2018

Association of time to craniectomy with survival in patients with severe combat-related brain injury.

Authors:

Neurosurg Focus 2018 Dec;45(6):E2

OBJECTIVEIn combat and austere environments, evacuation to a location with neurosurgery capability is challenging. A planning target in terms of time to neurosurgery is paramount to inform prepositioning of neurosurgical and transport resources to support a population at risk. This study sought to examine the association of wait time to craniectomy with mortality in patients with severe combat-related brain injury who received decompressive craniectomy. Read More

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December 2018

Direct enhancement of readiness for wartime critical specialties by civilian-military partnerships for neurosurgical care: residency training and beyond.

Authors:

Neurosurg Focus 2018 Dec;45(6):E17

Military neurosurgery has played an integral role in the development and innovation of neurosurgery and neurocritical care in treating battlefield injuries. It is of paramount importance to continue to train and prepare the next generation of military neurosurgeons. For the Army, this is currently primarily achieved through the military neurosurgery residency at the National Capital Consortium and through full-time out-service positions at the Veterans Affairs-Department of Defense partnerships with the University of Florida, the University of Texas-San Antonio, and Baylor University. Read More

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December 2018

Acute neurosurgical management of traumatic brain injury and spinal cord injury in French armed forces during deployment.

Authors:

Neurosurg Focus 2018 Dec;45(6):E9

This article aims to describe the French concept regarding combat casualty neurosurgical care from the theater of operations to a homeland hospital. French military neurosurgeons are not routinely deployed to all combat zones. As a consequence, general surgeons initially treat neurosurgical wounds. Read More

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December 2018

Two-year mortality and functional outcomes in combat-related penetrating brain injury: battlefield through rehabilitation.

Authors:

Neurosurg Focus 2018 Dec;45(6):E4

OBJECTIVEThere are limited data concerning the long-term functional outcomes of patients with penetrating brain injury. Reports from civilian cohorts are small because of the high reported mortality rates (as high as 90%). Data from military populations suggest a better prognosis for penetrating brain injury, but previous reports are hampered by analyses that exclude the point of injury. Read More

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December 2018

What Isn't a Case-Control Study?

Neurosurgery 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Confusion exists among neurosurgeons when choosing and implementing an appropriate study design and statistical methods when conducting research. We noticed particular difficulty with mislabeled and inappropriate case-control studies in the neurosurgical literature.

Objective: To quantify and to rigorously review this issue for appropriateness in publication and to establish quality of the manuscripts using a rigorous technique. Read More

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December 2018

Letter: Should Mindfulness be Incorporated as a Mandatory Component of Neurosurgical Training?

Neurosurgery 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Neurosciences Western General Hospital Edinburgh, United Kingdom.

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December 2018

Gene Therapy for Neurodegenerative Diseases.

Neurotherapeutics 2018 Dec 12. Epub 2018 Dec 12.

Brain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15213, USA.

Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases through several means, including direct correction of pathogenic mechanisms, neuroprotection, neurorestoration, and symptom control. Therapeutic efficacy is therefore dependent on knowledge of the disease pathogenesis and the required temporal and spatial specificity of gene expression. An additional critical challenge is achieving the most complete transduction of the target structure while avoiding leakage into neighboring regions or perivascular spaces. Read More

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December 2018

Tractography for Surgical Neuro-Oncology Planning: Towards a Gold Standard.

Neurotherapeutics 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Palo Alto, CA, 94304, USA.

Magnetic resonance imaging tractography permits in vivo visualization of white matter structures. Aside from its academic value, tractography has been proven particularly useful to neurosurgeons for preoperative planning. Preoperative tractography permits both qualitative and quantitative analyses of tumor effects upon surrounding white matter, allowing the surgeon to specifically tailor their operative approach. Read More

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December 2018

A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma.

Oncol Rep 2018 Nov 2. Epub 2018 Nov 2.

Department of Cell Biology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, P.R. China.

Clinical non‑functioning pituitary adenoma (NFPA) accounts for >30% of all pituitary adenomas, and the recurrence rate is notably high. The ability to predict tumour recurrence during initial surgery will aid in determining if adjunctive therapy is required to reduce recurrence. With the aim of developing a circular RNA (circRNA) signature to improve prognosis prediction in NFPA, the present study examined the circRNA expression profiles in 73 patients with NFPA from Beijing Tiantan Hospital using high‑throughput RNA chip technology. Read More

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November 2018

Prediction of brain invasion in patients with meningiomas using preoperative magnetic resonance imaging.

Oncotarget 2018 Nov 13;9(89):35974-35982. Epub 2018 Nov 13.

Department of Neurosurgery, University Hospital Münster, Münster, North Rhine-Westphalia, Germany.

Brain invasion (BI) in meningiomas impacts WHO grading and therefore adjuvant treatment. However, BI is rare and neurosurgical sampling and neuropathological analyses are not standardised. Moreover, associations with imaging findings are sparsely known. Read More

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November 2018

Call to participate in the international study of traumatic brain injury results (Global Neurotrauma Outcomes Study).

Neurocirugia (Astur) 2018 Dec 9. Epub 2018 Dec 9.

Departamento de Neurocirugía, Addenbrookés Hospital, Cambridge, Reino Unido.

Traumatic brain injury (TBI) accounts for a significant amount of death and disability worldwide and the majority of this burden affects individuals in low-and-middle income countries. The GNOS is a multi-centre international, prospective cohort study. This study is the first global neurosurgical study that aims to provide a comprehensive picture of the management and outcomes of patients undergoing emergency surgery for TBI worldwide. Read More

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December 2018

ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2.

Cancer Cell Int 2018 3;18:196. Epub 2018 Dec 3.

1Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Background: RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity. Dysregulation of A-to-I editing has been found associated with a number of nervous system diseases. However, the role of ADAR3, a brain specific high expression adenosine deaminase, in gliomas has rarely been investigated. Read More

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December 2018

Use of optical fluorescence agents during surgery for pituitary adenomas: current state of the field.

J Neurooncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Introduction: Differentiation of normal pituitary from abnormal tumor tissue remains a surgical challenge despite improvements in optical visualization technology for pituitary adenoma (PA) surgery. During neurosurgical procedures for other tumor types, 5-aminolevulinic acid (5-ALA) has become a focus of investigation based on its high specificity in differentiating tumor tissue. However, the role of 5-ALA and other optical fluorescent agents in PA surgery remains less clear. Read More

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December 2018

Obese Patients Benefit, but do not Fare as Well as Nonobese Patients, Following Lumbar Spondylolisthesis Surgery: An Analysis of the Quality Outcomes Database.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurological Surgery, University of California, San Francisco, California.

Background: Given recent differing findings following 2 randomized clinical trials on degenerative lumbar spondylolisthesis (DLS) surgery, there is a need to better define how subsets of patients fare following surgery.

Objective: To investigate the impact of obesity on patient-reported outcomes (PROs) following DLS surgery.

Methods: A total of 12 high-enrolling sites were queried, and we found 797 patients undergoing surgery for grade 1 DLS. Read More

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December 2018
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Comparison of PED and FRED Flow Diverters for Internal Carotid Artery Aneurysms: A Propensity Score-Matched Cohort Study.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, Paracelsus Medical University, Salzburg, Austria.

Background: Flow diversion has become an accepted endovascular treatment modality for intracranial aneurysms. Studies comparing different types of flow diverters are currently lacking.

Objective: To perform a propensity score-matched cohort study comparing the Pipeline Embolization Device (PED; Medtronic, Dublin, Ireland) and Flow Redirection Endoluminal Device (FRED; MicroVention, Aliso Viejo, California). Read More

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December 2018
2 Reads

[Aspects of nutrition therapy of an infant with central nervous system tumour].

Magy Onkol 2018 Dec 22;62(4):237-241. Epub 2018 Nov 22.

II. Sz. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary.

The atypical teratoid/rhabdoid tumour (ATRT) is a rare type of central nervous system tumour appearing usually under 2 years of age. The survival of patients is insufficient despite the combined treatment (neurosurgical removal, intensive chemo- and radiotherapy). ATRT recurs one year after completion of treatment in 60% of cases. Read More

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December 2018

Clinical Features and Prognostic Risk Factors of Choroid Plexus Tumors in Children.

Chin Med J (Engl) 2018 Dec;131(24):2938-2946

Department of Neurosurgery, Beijing Tiantan Hospital; Department of Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.

Background: Decision-making concerning the treatment of choroid plexus tumor (CPT) in pediatric patients remains a topic of considerable debate. The aim of this work was to describe clinical features and prognostic risk factors of CPT in the pediatric population and to provide theoretical opinions regarding clinical decisions for CPT.

Methods: The data of 96 patients with CPT and younger than 14 years were retrospectively analyzed. Read More

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December 2018
1 Read
1.016 Impact Factor

Predictive and individualized management of stroke-success story in Czech Republic.

EPMA J 2018 Dec 25;9(4):393-401. Epub 2018 Oct 25.

1Department of Neurology, Faculty of Medicine in Pilsen, Charles University, Husova 3, 301 66 Plzen, Czech Republic.

The model of centralized stroke care in the Czech Republic was created in 2010-2012 by Ministry of Health (MH) in cooperation with professional organization-Cerebrovascular Section of the Czech Neurological Society (CSCNS). It defines priorities of stroke care, stroke centers, triage of suspected stroke patients, stroke care quality indicators, their monitoring, and reporting. Thirteen complex cerebrovascular centers (CCC) provide sophisticated stroke care, including intravenous thrombolysis (IVT), mechanical thrombectomy (MTE), as well as other endovascular (stenting, coiling) and neurosurgical procedures. Read More

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December 2018
1 Read

ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma.

Cell Death Dis 2018 Dec 11;9(12):1190. Epub 2018 Dec 11.

Chinese Glioma Genome Atlas Network(CGGA) and Asian Glioma Genome Atlas Network (AGGA), Beijing, China.

As aldehyde dehydrogenase (ALDH) is a novel stem cell marker, increasing studies have confirmed that high ALDH activity promotes tumorigenesis and progression in cancers. Some preliminary studies have found that ALDH1A3 may play an important role in glioma malignant progression, but so far there was no conclusive conclusion. The purpose of our study was to elucidate the mechanisms by which ALDH1A3 regulated in glioma and to provide practical tools for clinical application. Read More

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December 2018
1 Read
5.014 Impact Factor

Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells.

Biofabrication 2018 Dec 11. Epub 2018 Dec 11.

Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing, CHINA.

Growth-hormone-secreting pituitary adenoma (GHSPA) is a benign tumour with a high incidence and large economic burden, which greatly affects quality of life. The aetiological factors are yet to be clarified for GHSPA. Conventional two-dimensional (2D) monolayer culture of tumour cells cannot ideally reflect the growth status of tumours in the physiological environment, and insufficiencies of in vitro models have severely restricted the progress of cancer research. Read More

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December 2018
1 Read
4.289 Impact Factor

Predictors of cognitive function in the acute phase after aneurysmal subarachnoid hemorrhage.

Acta Neurochir (Wien) 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, P.B. 4950, Nydalen, 0424, Oslo, Norway.

Background: Cognitive dysfunction is the most common form of neurological impairment after aneurysmal subarachnoid hemorrhage (aSAH) in the chronic phase. Cognitive deficits in the acute phase after aSAH, however, remain scarcely investigated. The aim of the present study was to test cognitive function and to identify medical predictors of cognitive deficits in the acute phase of aSAH. Read More

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December 2018
2 Reads

Social media for dissemination and public engagement in neurosurgery-the example of Brainbook.

Acta Neurochir (Wien) 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, The Royal London Hospital, London, UK.

Background: Public engagement has become one of the most effective tools in gaining feedback and perspectives from members of the public, involving patients with decisions, and inspiring young people to carry the medical profession forwards. Brainbook is a multi-platform, social media-based resource that was created specifically to enhance public engagement in neurosurgery and results from one of its case discussions will be reported in this paper.

Methods: A Brainbook case was created in collaboration with the NIHR Global Health Research Group on Neurotrauma and presented over 3 days (23-25 February 2018). Read More

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December 2018

Estimation of the number of feeding arteries of spinal arteriovenous malformations by using three-dimensional digital subtraction angiography.

Eur Spine J 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Purpose: Spinal angiography is the gold standard for evaluation or diagnosis of spinal arteriovenous malformations (AVMs). However, some feeding arteries might be overlooked when multiple feeders exist. This study aimed to retrospectively review cases of spinal intra-dural AVMs, which were identified by three-dimensional digital subtraction angiography (3D-DSA), and attempted to estimate the number of feeding arteries. Read More

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December 2018

What is a Case-Control Study?

Neurosurgery 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, University of Alabama at Birmingham.

Case-control (case-control, case-controlled) studies are beginning to appear more frequently in the neurosurgical literature. They can be more robust, if well designed, than the typical case series or even cohort study to determine or refine treatment algorithms. The purpose of this review is to define and explore the differences between case-control studies and other so-called nonexperimental, quasiexperimental, or observational studies in determining preferred treatments for neurosurgical patients. Read More

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December 2018

Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with an external ventricular drain.

J Antimicrob Chemother 2018 Dec 6. Epub 2018 Dec 6.

Département d'Infectiologie, CHU and INSERM CIC1432, Université de Bourgogne, Dijon, France.

Background: Owing to its antibacterial properties, ceftaroline could be attractive for prevention or treatment of bacterial post-neurosurgical meningitis/ventriculitis. However, few data are available concerning its meningeal concentrations.

Objectives: To investigate ceftaroline CSF pharmacokinetics in ICU patients with an external ventricular drain (EVD). Read More

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December 2018