33,362 results match your criteria Neuroscience Letters [Journal]


Multimodal classification of drug-naïve first-episode schizophrenia combining anatomical, diffusion and resting state functional resonance imaging.

Neurosci Lett 2019 Apr 22. Epub 2019 Apr 22.

Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

The accurate diagnosis in the early stage of schizophrenia (SZ) is of great importance yet remains challenging. The classification between SZ and control groups based on magnetic resonance imaging (MRI) data using machine learning method could be helpful for SZ diagnosis. Increasing evidence showed that the combination of multimodal MRI data might further improve the classification performance However, medication effect has a profound influence on patients' anatomical and functional features and may reduce the classification efficiency. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.039DOI Listing

Pyrroloquinoline quinone improves abnormal functional development of whisker-mediated tactile perception and social behaviors caused by neonatal whisker trimming.

Neurosci Lett 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Daigaku-nisi, 1-25-4, Gifu, 501-1196, Japan. Electronic address:

Abnormalities in tactile perception and response, such as sensory defensiveness, are core features of autism spectrum disorder (ASD) and may be associated with impaired communication skills. However, the influences of tactile perception deficits on the development of social behaviors and neuronal circuits related to emotional regulation of social interactions remain unclear. Whiskers are the most important tactile apparatus in rodents. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.040DOI Listing

ERP Differences in Processing Canonical and Noncanonical Finger-Numeral Configurations.

Neurosci Lett 2019 Apr 20. Epub 2019 Apr 20.

The University of Alabama, College of Education, Box 870231, Tuscaloosa, AL, 35487, United States.

Finger-numeral configurations are used to represent numerosities, to count, and to do arithmetic across cultures. Previous research has distinguished between two forms of finger-numeral configurations; finger montring and finger counting. Montring refers to how people raise their fingers to show numerosities to others and usually serves a communicative function. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.032DOI Listing

CEP55 promoted the migration, invasion and neuroshpere formation of the glioma cell line U251.

Neurosci Lett 2019 Apr 18. Epub 2019 Apr 18.

Department of cell biology and Neurobiology, Xuzhou Key Laboratory of Neurobiology, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China. Electronic address:

Glioma stem cells (GSC) were important for Glioblastoma (GBM) initiation and chemotherapy resistance. Centrosomal protein of 55 kDa (CEP55) was a biomarker for multiple cancers. However, roles and mechanism of CEP55 in glioma tumorigenesis and stemness maintains of stem like cells was still unclear. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.038DOI Listing

Rewarding effects of 2-desoxypipradrol in mice.

Neurosci Lett 2019 Apr 18. Epub 2019 Apr 18.

Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi, 28159, Republic of Korea.

Desoxypipradrol (2-DPMP), a new psychoactive substance (NPS), acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). NDRIs can be addictive due to their action mechanisms similar to cocaine and methamphetamine. However, there is a lack of scientific information regarding the exact dependency of 2-DPMP. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.037DOI Listing

Early stage of diffusional kurtosis imaging and dynamic contrast-enhanced magnetic resonance imaging correlated with long-term neurocognitive function after experimental traumatic brain injury.

Neurosci Lett 2019 Apr 18. Epub 2019 Apr 18.

Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China; Imaging Center, Kashgar Prefecture Second People's Hospital, Kashgar, Xinjiang, 844000, China. Electronic address:

Development of a reliable biomarker for prognostic monitoring of cognitive impairment after traumatic brain injury (TBI) is of great importance. The aim of the study was to explore the value of early diffusional kurtosis imaging (DKI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in evaluation of chronic cognitive function after TBI. MRI was performed on TBI and control rats at 7 days post-injury. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.034DOI Listing
April 2019
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Rapamycin relieves inflammation of experimental autoimmune encephalomyelitis by altering the balance of Treg/Th17 in a mouse model.

Neurosci Lett 2019 Apr 17;705:39-45. Epub 2019 Apr 17.

Department of Neurology, the second Hospital of Hebei Medical University, ShiJiaZhuang, Hebei, 050000, China.

This study was to observed the different doses of rapamycin on the treatment of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. 63 female C57BL/6 mice (6-8 weeks) was chosen and randomly divided into three groups: control, low-dose rapamycin-treated EAE mice (0.3 mg/kg), and high-dose rapamycin-treated EAE mice (1 mg/kg). Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.035DOI Listing

The relationship between inflammasomes and the endoplasmic reticulum stress response in the injured spinal cord.

Neurosci Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine Isehara, Japan. Electronic address:

Study Design animal study Objectives The aim of this study is to investigate the influence of inflammasomes in the injured spinal cord of a rat spinal cord injury model. Setting University laboratory in Kanagawa, Japan Methods A thoracic contusion spinal cord injury (SCI) was induced in female Sprague Dawley rats using an IH-impactor to create a moderate injury group (LI) and a severe injury group (HI). Using a sham group as a control, the injured spinal cords were removed at several time points after injury to evaluate the levels of inflammasome component proteins in the injured spinal cord by immunohistochemistry and Western Blot. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.033DOI Listing

Acupuncture reduces nicotine-induced norepinephrine release in the hypothalamus via the solitary NMDA receptor/NOS pathway.

Neurosci Lett 2019 Apr 17;705:33-38. Epub 2019 Apr 17.

Department of Psychopharmacology, Qiqihar Medical University, Qiqihar, 161006, China; MRC-GHF, College of Korean Medicine, Daegu Haany University, Gyeongsan, 38610, Republic of Korea. Electronic address:

Noradrenergic projections from the nucleus tractus solitarius (NTS) to the hypothalamic paraventricular nucleus (PVN) are involved in nicotine (Nic) dependence. Nic induces hypothalamic norepinephrine (NE) release through N-methyl-d-aspartate receptors (NMDARs) and nitric oxide in the NTS. However, acupuncture attenuates Nic withdrawal-induced anxiety. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.036DOI Listing
April 2019
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Benefit of wakeful resting on gist and peripheral memory retrieval in healthy younger and older adults.

Neurosci Lett 2019 Apr 15;705:27-32. Epub 2019 Apr 15.

Human Cognitive Neuroscience, Psychology, University of Edinburgh, Edinburgh, UK.

Retrieval is greater if new learning is followed by a period of wakeful rest, minimising the likelihood of retroactive interference. It is not known if this benefit extends to recollection of both gist and peripheral details, nor whether age affects the benefit of wakeful resting in either of these types of recollection. Forty-five younger and forty older adults were presented with prose passages for later recall followed by a period of either interference or wakeful resting. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.026DOI Listing

Sensitization of nociceptors and dorsal horn neurons contributes to pain in sickle cell disease.

Neurosci Lett 2019 Apr 14;705:20-26. Epub 2019 Apr 14.

Department of Diagnostic and Biological Sciences, University of Minnesota, School of Dentistry, Minneapolis, MN 55455, United States. Electronic address:

Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle red blood cells. Vaso-occlusion episodes caused by accumulation of sRBCs results in ischemia-reperfusion injury, reduced oxygen supply to organs, oxidative stress, organ damage and severe pain that often requires hospitalization and opioid treatment. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.013DOI Listing
April 2019
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Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease.

Neurosci Lett 2019 Apr 14;705:7-13. Epub 2019 Apr 14.

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, United Kingdom.

The discovery of rare familial monogenic forms of early-onset Parkinson's disease has led to the identification of a mitochondrial quality control process as a key player in this disease. Loss-of-function mutations in the genes encoding PINK1 or Parkin result in insufficient removal of dysfunctional mitochondria through autophagy, a process termed mitophagy. Understanding the mechanism of this process and the function of its two key players, PINK1 and Parkin, has led to the discovery of new therapeutic approaches. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.029DOI Listing
April 2019
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The TAAR5 agonist α-NETA causes dyskinesia in mice.

Neurosci Lett 2019 Apr 12;704:208-211. Epub 2019 Apr 12.

Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034, St Petersburg, Russia. Electronic address:

It is known that trace amine-associated receptor 5 (TAAR5) is expressed in various regions of the central nervous system. However, very limited information is available on the behavioral effects of TAAR5 activation and the TAAR5 functional role, in general. We studied the effect of TAAR5 agonist (2-(alpha-naphthoyl) ethyltrimethylammonium iodide) systemic administration on animal behavior. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.028DOI Listing
April 2019
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The effects of dihydroxyphenyl lactic acid on alleviating blood-brain barrier injury following subarachnoid hemorrhage in rats.

Neurosci Lett 2019 Apr 10;704:189-194. Epub 2019 Apr 10.

Department of Anatomy and Histology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China; Beijing Key Lab of Magnetic Resonance Imaging Technology, Beijing, 100191, China. Electronic address:

Background: In this study, the protective effects of 3,4-dihydroxyphenyl lactic acid (DLA) on blood-brain barrier (BBB) injury following subarachnoid hemorrhage (SAH) has been explored.

Methods: Male Sprague-Dawley rats (weight 300-350 g) were used to establish the SAH model using the endovascular perforation method. The animals were randomly divided into four groups: sham (n = 40), SAH (n = 46), SAH + vehicle (n = 44), and SAH + DLA (n = 40) treatment groups. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.025DOI Listing
April 2019
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Neurological effects of product price and evaluation on online purchases based on event-related potentials.

Neurosci Lett 2019 Apr 9;704:176-180. Epub 2019 Apr 9.

School of Economics and Management, Yanshan University, Qinhuangdao, 066004, China.

In order to better understand how price and evaluation impact consumers' decision making, this research examined the neural bases underlying consumers' cognition of the two important clues when shopping online. An ERP experiment was conducted involving 19 Chinese students and the behavior data revealed that product price and evaluation significantly influenced their willingness to purchase mobile phones online, and the speed with which they made purchase decisions supported cue-diagnosis theory. Further, ERP results indicated three neural stages of decision-making: early automatic cognition with emotional valence and negativity bias effects elicited by product evaluation ratings, an evaluation stage exhibiting an attention, and a final stage featuring an evaluation-categorization pattern associated with pleasurable sensations. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.019DOI Listing

Association between the novel seizure quality index for the outcome prediction in electroconvulsive therapy and brain-derived neurotrophic factor serum levels.

Neurosci Lett 2019 Apr 9;704:164-168. Epub 2019 Apr 9.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

The novel Seizure Quality Index (SQI) could predict the risk of non-response and non-remission as early as after the second electroconvulsive therapy (ECT) session based the extent of several ictal parameters of the seizure in patients with depression. The association between those indices with the peripheral serum levels of brain-derived neurotrophic factor (BDNF) was evaluated in this study. It was proposed that seizure quality reflected by the SQI will be positively correlated with the levels of serum BDNF after ECT in patients with depression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193025
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http://dx.doi.org/10.1016/j.neulet.2019.04.023DOI Listing
April 2019
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The comparison of the comodulation masking release (CMR) in individuals with and without chronic tinnitus.

Neurosci Lett 2019 Apr 9;704:195-200. Epub 2019 Apr 9.

Enphil of Iran University of Medical Sciences, Department of Audiology, School of Rehabilitation Sciences, Tehran, Iran. Electronic address:

In comodulation masking release (CMR), the auditory signal threshold improves when maskers far from the frequency of the target signal are coherently amplitude-modulated. Studies show that inhibitory function may play a role in CMR. In individuals who have tinnitus, decreasing inhibitory functioning in auditory central nervous system has been documented. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.018DOI Listing

Riluzole blocks HU210-facilitated ventral tegmental long-term depression by enhancing glutamate uptake in astrocytes.

Neurosci Lett 2019 Apr 9;704:201-207. Epub 2019 Apr 9.

Department of Neurology, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China. Electronic address:

The lifetime prevalence of addiction to cannabis (marijuana or cannabinoids) is among the highest of that of all illicit drugs in developed countries, and no effective treatment for cannabis addiction is currently available. Previous studies in our research group suggested that astrocyte-mediated long-term depression (LTD) in ventral tegmental area (VTA) dopamine neurons plays a pivotal role in the development of cannabis addiction. The present study was designed to investigate the effects and potential mechanisms of riluzole, a drug used for the treatment of motor neuron diseases, on cannabinoid-facilitated LTD induction. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.021DOI Listing
April 2019
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Finding the Vanished Self: Perspective Modulates Neural Substrates of Self-Reflection in Buddhists.

Neurosci Lett 2019 Apr 9. Epub 2019 Apr 9.

School of Psychological and Cognitive Sciences, Peking University, Beijing, China; Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China; MOE Key Laboratory of Machine Perception, Peking University, Beijing, China. Electronic address:

Asians' self-views are flexible and influenced by short-term situational and long-term cultural factors. Due to the long-term religious cultural influence of Chinese Buddhism, Buddhists showed no self-advantage in behavioral and neural level in many previous studies. However, it is unclear whether Chinese Buddhists really have no self-awareness or self-concept. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.024DOI Listing

Erythropoietin ameliorates harmaline-induced essential tremor and cognition disturbances.

Neurosci Lett 2019 Apr 8;704:153-158. Epub 2019 Apr 8.

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

There are conflicting reports concerning the association of motor disabilities with increased risk of mental disorders. This investigation will provide a good understanding about defining the possible association between tremor and risk of anxiety and cognitive alterations. Beside, a secondary objective of the current study was to determine the effect of erythropoietin (EPO) on harmaline-induced motor and cognitive impairments. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.017DOI Listing
April 2019
2.055 Impact Factor

An inducible model of human amylin overexpression reveals diverse transcriptional changes.

Neurosci Lett 2019 Apr 8;704:212-219. Epub 2019 Apr 8.

Department of Biological Sciences, The George Washington University, Science and Engineering Hall 6000, 800 22nd St. N.W., Washington DC, 20052, USA; Institute for Neuroscience, The George Washington University, 636 Ross Hall, 2300 I St. N.W. Washington DC, 20052, USA. Electronic address:

Human Islet Amyloid Polypeptide or amylin is a neuroendocrine peptide with important endocrine and paracrine functions. Excessive production and accumulation of human amylin in the pancreas can lead to its aggregation and apoptosis of islet β-cells. Amylin has been shown to function within the central nervous system to decrease food intake, and more recently, it has been revealed that amylin is directly transcribed from neurons of the central nervous system, including the hypothalamus, arcuate nucleus, medial preoptic area, and nucleus accumbens. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.016DOI Listing
April 2019
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DNA methylation regulates CHRNA7 transcription and can be modulated by valproate.

Neurosci Lett 2019 Apr 8;704:145-152. Epub 2019 Apr 8.

Laboratory of Metabolism Modifying Medicine, Department of Health Science and Technology, Aalborg University, Denmark. Electronic address:

The CHRNA7 gene encoding the α7 nicotinic acetylcholine receptor (nAChR) has repeatedly been linked with schizophrenia and the P50 sensory gating deficit. The α7 nAChR is considered a promising drug target for treatment of cognitive dysfunction in schizophrenia and improves memory and executive functions in patients and healthy individuals. However, clinical trials with pro-cognitive drugs are challenged by large inter-individual response variations and these have been linked to genotypic variations reducing CHRNA7 expression and α7 nAChR function. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193024
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http://dx.doi.org/10.1016/j.neulet.2019.04.015DOI Listing
April 2019
2 Reads

A rather than A adenosine receptor as a possible target of Guanosine effects on mitochondrial dysfunction following Traumatic Brain Injury in rats.

Neurosci Lett 2019 Apr 8;704:141-144. Epub 2019 Apr 8.

Laboratory of Exercise Biochemistry, Center for Physical Education and Sports, Federal University of Santa Maria, Santa Maria, RS, Brazil.

Traumatic brain injury (TBI) represents one of the leading causes of death worldwide. Its pathophysiology involves several neurochemical events including mitochondrial dysfunction. Since mitochondrial respiration plays a key role in cell survival, pharmacological interventions targeting mitochondrial function have been highlighted as a powerful tool against the neurodegenerative process triggered by TBI. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.014DOI Listing
April 2019
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Does 5, 7-Dihydroxytryptamine injection into nucleus accumbens cause hyperacusis?

Neurosci Lett 2019 Apr 7. Epub 2019 Apr 7.

Tehran university, peach e shemiran, Tehran, Iran.

Hyperacusis may be defined as diminishing tolerance to moderate and high intensity sounds in people with normal hearing sensitivity. Serotonin plays a critical role in some of auditory tasks including startle reflex and prepulse inhibition. Serotonin deficiency can cause some diseases which can coincide with hyperacusis. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.040DOI Listing
April 2019
2.055 Impact Factor

ADAM23 is a negative regulator of K1.1/K1.4 potassium currents.

Neurosci Lett 2019 Apr 6;704:159-163. Epub 2019 Apr 6.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States. Electronic address:

Background ADAM22 and ADAM23 are transmembrane proteins that bind the secreted synaptic protein LGI1 and associate with K1.1/K1.4 potassium channels. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.012DOI Listing
April 2019
3 Reads

Psychosocial and affective comorbidities in sickle cell disease.

Neurosci Lett 2019 Apr 6;705:1-6. Epub 2019 Apr 6.

Division of Hematology, Center for Cancer and Blood Disorders, Children's National Medical Center, Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington D.C., United States. Electronic address:

Psychosocial and affective comorbidities are common in sickle cell disease (SCD) and can strongly influence disease outcomes, especially those related to pain such as frequency and intensity of pain, use of emergency- and hospital-based care and opioid use. Depression, anxiety, sleep disorders, and substance use challenges are among the common comorbidities that inform the patient experience of SCD. Underlying neurocognitive changes may also contribute to the expression of affective disorders in people with SCD. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.011DOI Listing
April 2019
2 Reads

Effects of pycnogenol on ischemia/reperfusion-induced inflammatory and oxidative brain injury in rats.

Neurosci Lett 2019 Apr 6;704:169-175. Epub 2019 Apr 6.

Department of Pharmacology, Erzincan Binali Yildirim University School of Medicine, Erzincan, Turkey. Electronic address:

Background: Ischemia/reperfusion (I/R) injury results from the onset of re-circulation following a perfusion deterioration period in the tissues, resulting in more damage than that caused by perfusion deterioration. This study aimed to determine the effects of pycnogenol on I/R injury in rat brain tissues.

Methods: Eighteen albino Wistar rats were divided into three groups: I/R injury (IR, n = 6) group; I/R injury + pycnogenol (IR + P, n = 6) group; and sham group (SG, n = 6). Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.010DOI Listing
April 2019
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Effect of naturally occurring α-synuclein-antibodies on toxic α-synuclein-fragments.

Neurosci Lett 2019 Apr 4;704:181-188. Epub 2019 Apr 4.

Department of Neurology, Philipps-University of Marburg, Marburg, Germany. Electronic address:

Alpha-synuclein (α-Syn) is a soluble protein primarily expressed in presynaptic terminals in the central nervous system (CNS). Aggregates of fibrillated α-Syn are the major component of Lewy bodies (LB), a pathologic hallmark of idiopathic Parkinson's disease (PD). Recently, naturally occurring autoantibodies against human α-Syn (nAbs α-Syn) were detected in the peripheral blood of PD patients and controls. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.004DOI Listing
April 2019
6 Reads

Autophagy dysfunction in peripheral blood mononuclear cells of Parkinson's disease patients.

Neurosci Lett 2019 Apr 4;704:112-115. Epub 2019 Apr 4.

Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; 1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Background: Alpha-synuclein aggregation is considered one of the main causes of Parkinson's Disease (PD). Malfunction of autophagy-lysosomal pathways is believed to be an underlying mechanism of α-synuclein aggregation. Although such malfunction has been observed in PD brains, it is unclear whether it may also occur in extraneuronal tissues. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.003DOI Listing
April 2019
3 Reads

Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice.

Neurosci Lett 2019 Apr 4;704:133-140. Epub 2019 Apr 4.

Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Alzheimer's disease (AD) is the most common type of dementia in aging adults. Increasing evidence has revealed that vascular risk factors influence the midlife development of AD and that diet-induced obesity accelerates tau phosphorylation in tau transgenic mice and increases the level of serum leptin receptor (leptin-R). Leptin-R is upregulated in the peri-infarct cortices after acute cerebral ischemia. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.009DOI Listing
April 2019
3 Reads

Upregulation of proteoglycans in the perilesion perimeter in ventral horns after spinal cord injury.

Neurosci Lett 2019 Apr 3;704:220-228. Epub 2019 Apr 3.

Department of Histology, Cytology and Embryology, Kazan State Medical University, Kazan, Russia; Department of Medical Physics, Institute of Physics, Kazan (Volga Region) Federal University, Kazan, Russia.

Spinal cord injury (SCI) results in pronounced focal tissue damage with subsequent formation of a glial scar that blocks axon regeneration and regrowth. Cellular changes and the composition of the extracellular matrix in regions distal from the injured area remain poorly characterized. In the present study, in the spinal cord distal to the damaged area (perilesion perimeter) there were minimal gross histological changes, but there were pronounced alterations in the extracellular proteoglycans even at 30 days after SCI. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.006DOI Listing

Aqueous extracts of se-enriched Auricularia auricular attenuates D-galactose-induced cognitive deficits, oxidative stress and neuroinflammation via suppressing RAGE/MAPK/NF-κB pathway.

Neurosci Lett 2019 Apr 3;704:106-111. Epub 2019 Apr 3.

Institute of Agricultural Quality Standards and Testing Technology, Jilin Academy of Agricultural Sciences, Changchun, 130033, China. Electronic address:

Aging is a natural process that accompanied with progressive cognitive deficits and functional decline in organisms. Selenium (Se), an essential trace element, exhibits antioxidative and anti-inflammatory abilities. Here, our study aimed to investigate the protective effects of aqueous extracts of Se-enriched Auricularia auricular (AESAA) on aging mice induced by d-galactose (D-gal) and explore its potential mechanism. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.002DOI Listing
April 2019
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Effect of TGF-beta1 on long-term synaptic plasticity and distribution of AMPA receptors in the CA1 field of the hippocampus.

Neurosci Lett 2019 Apr 3;704:95-99. Epub 2019 Apr 3.

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia; Pushchino State Institute of Natural Sciences, Pushchino, Moscow Region, 142290, Russia.

Using the methods of electrophysiology and immunohistochemistry, the effect of the transforming factor beta-1(TGF-β1), an anti-inflammatory cytokine, on the long-term post-tetanic potentiation (LTP) in CA1 field hippocampal slices and the distribution of the GluR1 subunit of the AMPA receptor has been studied. It was shown that TGF-β1 at a concentration of 10 ng/ml did not significantly affect the initial stage of LTP and substantially changed the distribution of synaptic AMPA receptors in response to tetanic stimulation. Twenty five minutes after the tetanization, the main pool of AMPA receptors (90%) was due to the postsynaptic density (PSD). Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.005DOI Listing
April 2019
1 Read

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.

Neurosci Lett 2019 Apr 3;704:89-94. Epub 2019 Apr 3.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.

Amyotrophic lateral sclerosis (ALS) is a heterogeneous motor neuron disease with familial forms linked to numerous mutations in a range of genes. The resulting variant proteins, including SOD1, TDP-43, and FUS, disturb protein homeostasis in a variety of ways and lead to the formation of intracellular inclusion bodies that are characteristic of different neuropathological subtypes of the disease. These inclusions are made up of scores of proteins that do not appear at first to share obvious characteristics other than coaggregation. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.001DOI Listing

Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.

Neurosci Lett 2019 Apr 4;704:116-125. Epub 2019 Apr 4.

Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address:

In multiple sclerosis (MS) regeneration of oligodendrocytes following inflammatory demyelination is limited by the compromised ability of progenitors to repopulate lesioned areas and transition to functionally competent oligodendrocytes. Regarding underlying mechanisms, the involvement of epigenetic processes has been suggested, e.g. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.007DOI Listing
April 2019
1 Read

Functional MRI of the mouse olfactory system.

Neurosci Lett 2019 Apr 2;704:57-61. Epub 2019 Apr 2.

Department of Medicine, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States; South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX, 78229, United States. Electronic address:

Although olfactory dysfunction is an early warning sign of Alzheimer's and Parkinson's diseases, and is commonly present in a range of other neurodegenerative disorders, the mechanisms for its pathogenesis are not yet clear. Since fMRI allows the mapping of spatial and temporal patterns of activity in multiple brain regions simultaneously, it serves as a powerful tool to study olfactory dysfunction in animal models of neurodegenerative diseases. Nonetheless, there have been no reports to date of mapping odor-induced activation patterns beyond the olfactory bulb to the extended networks of olfactory and limbic archicortex, likely due to the small size of the mouse brain. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.055DOI Listing

Nitrated alpha-synuclein in minor salivary gland biopsies in Parkinson's disease.

Neurosci Lett 2019 Apr 1;704:45-49. Epub 2019 Apr 1.

Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing, China. Electronic address:

Alpha-synuclein (α-SYN) is found in peripheral autonomic neuronal network apart from brain in Parkinson's disease (PD). Nitrated α-SYN is an undesirable modification associated with oxidative and nitrative damage and has been found extensively in brain, gastrointestinal(GI) tract and blood cells in PD. We aim to investigate the presence of nitrated α-SYN in minor salivary gland biopsy in PD. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.054DOI Listing

Reciprocal interactions between the basolateral amygdala and infralimbic and prelimbic regions of the mPFC: Actions of diazepam.

Neurosci Lett 2019 Apr 1;704:78-83. Epub 2019 Apr 1.

Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, 91190, Mexico. Electronic address:

The basolateral amygdala (BLA) and prelimbic (PL) and infralimbic (IL) cortices are interconnected structures that participate in the regulation of fear. Unknown are the reciprocal functional influence of these regions on neuronal responsivity and the action of an anxiolytic drug. We performed multiunit activity recordings from one neuronal pool while applying electrical stimulation to another neuronal pool. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.051DOI Listing

Serotonergic system, cognition, and BPSD in Alzheimer's disease.

Neurosci Lett 2019 Apr 1;704:36-44. Epub 2019 Apr 1.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, 60611, USA. Electronic address:

Behavioral and Psychological Symptoms of Dementia (BPSD), present in almost 90% of patients with Alzheimer's Disease (AD), cause extensive impairment leading to reduced independence and inability to complete activities of daily living. Though BPSD includes a wide range of symptoms, such as agitation, aggression, disinhibition, anxiety, depression, apathy, delusions, and hallucinations. Certain BPSD in AD co-present and can be clustered into distinct domains based on their frequency of co-occurrence. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.050DOI Listing
April 2019
6 Reads

Phosphorylated NF-κB subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy.

Neurosci Lett 2019 Apr 1;704:229-235. Epub 2019 Apr 1.

Department of Neurology, Kyoto University Graduate School of Medicine, Japan. Electronic address:

Granulovacuolar degeneration (GVD) was originally reported in Alzheimer's disease (AD) and later found in aging brains. Pathologically, GVD is thought to be associated with the development of tauopathy, but the precise mechanism remains unknown. Previous studies have suggested that GVD contains proteins associated with an inflammatory signal. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193019
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http://dx.doi.org/10.1016/j.neulet.2019.03.036DOI Listing
April 2019
4 Reads

The effect of response complexity on simple reaction time occurs even with a highly predictable imperative stimulus.

Neurosci Lett 2019 Apr 1;704:62-66. Epub 2019 Apr 1.

School of Kinesiology, University of British Columbia, Canada.

It is well known that increasing the complexity of the required response results in a corresponding increase in simple reaction time (RT). This "response complexity effect" has typically been attributed to increased time required to prepare some aspect of the response; however, most studies examining the response complexity effect have used an unpredictable foreperiod, which does not allow for optimal preparation to occur. Thus, it is conceivable that response complexity effects are influenced by an inability to predict the occurrence of the go-signal. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.056DOI Listing

Nicotinic acetylcholine receptor α7 subunit maybe a risk factor of seizure susceptibility.

Neurosci Lett 2019 Apr 1;704:15-20. Epub 2019 Apr 1.

Department of Intensive Care Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China; Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China. Electronic address:

Previous studies have confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and neuropsychiatric diseases, but their effect on seizure susceptibility is not fully understood. Here, we show that decreased activity of α7 nAChRs increases the excitability of the CA1 pyramidal neurons and shortens the onset time of epilepsy in pilocarpine-induced mouse model. Compared with control group, however, there was no apparent difference upon increasing the activity of α7 nAChRs. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.053DOI Listing
April 2019
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The effect of language proficiency on L2 English learners' processing of morphologically complex words: Evidence from masked transposed letter priming.

Neurosci Lett 2019 Mar 31;704:84-88. Epub 2019 Mar 31.

College of Foreign Languages, Hunan University, Changsha, Hunan, 410082, PR China.

The relative sequence of morphological decomposition and whole-word recognition during morphologically complex word (MCW) processing has attracted much attention in recent years. However, most studies have only focused on inflected and derived words while disregarding compound words, and have mainly examined the differences between native speakers and L2 learners without addressing language proficiency levels. This paper investigates the language proficiency effect on L2 English learners' processing of all the three types of MCWs in a masked transposed letter priming paradigm. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.042DOI Listing
March 2019
1 Read

Adult hippocampal neurogenesis is not necessary for the response to lithium in the forced swim test.

Neurosci Lett 2019 Mar 30;704:67-72. Epub 2019 Mar 30.

Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

Chronic lithium treatment stimulates adult hippocampal neurogenesis, but whether increased neurogenesis contributes to its therapeutic mechanism remains unclear. We use a genetic model of neural progenitor cell (NPC) ablation to test whether a lithium-sensitive behavior requires hippocampal neurogenesis. NPC-ablated mice were treated with lithium and assessed in the forced swim test (FST). Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.052DOI Listing
March 2019
4 Reads

The parallel mechanism of semantic context influences and parafoveal word identification.

Neurosci Lett 2019 Mar 29;704:73-77. Epub 2019 Mar 29.

School of Psychology, South China Normal University, Guangzhou, 510631, China.

Previous event-related potential (ERP) studies have shown that the N400 effect tracks with the isolation point of a word in spoken language comprehension. These results suggested the semantic context of a sentence influences word processing before word identification. However, this delayed effect of N400 latency is not often the case in written language comprehension. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.026DOI Listing
March 2019
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Impairment of tactile responses and Piezo2 channel mechanotransduction in mice following chronic vincristine treatment.

Neurosci Lett 2019 Mar 29;705:14-19. Epub 2019 Mar 29.

Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL, 35294, USA. Electronic address:

Loss of the sense of touch or numbness in fingertips and toes is one of the earliest sensory dysfunctions in patients receiving chemotherapy with anti-cancer drugs such as vincristine. However, mechanisms underlying this chemotherapy-induced sensory dysfunction is poorly understood. Whisker hair follicles are tactile organs in non-primate mammals which are functionally equivalent to human fingertips. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.045DOI Listing
March 2019
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Ephrin-B2 inhibits Aβ-induced apoptosis by alleviating endoplasmic reticulum stress and promoting autophagy in HT22 cells.

Neurosci Lett 2019 Mar 30;704:50-56. Epub 2019 Mar 30.

Department of Pharmacology, Wannan Medical College, Wuhu, 241002, PR China. Electronic address:

Previous studies have shown that Erythropoietin-producing hepatocellular carcinoma receptor B2 (EphB2) inhibited Aβ-induced neuron apoptosis and improved cognition in AD mice, but the role of which ligand Ephrin B2 (Ephrin-B2, efnB2) is not clear. The aim of this study was to investigate the effect of the efnB2-activated Eph/efn forward signaling pathway on Aβ-induced HT22 hippocampal cell apoptosis using recombination mouse Ephrin B2-Fc chimera protein (efnB2-Fc). We found that non-toxic concentrations of efnB2-Fc decreased the release of lactate dehydrogenase (LDH) in HT22 cells and reduced cell apoptosis in a dose-dependent manner. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.028DOI Listing
March 2019
2.055 Impact Factor

Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use.

Neurosci Lett 2019 Mar 29;704:100-105. Epub 2019 Mar 29.

Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Ave, New York, NY, 10065, USA.

The dynorphin/kappa opioid receptor (Dyn/KOR) system is involved in reward processing and dysphoria/anhedonia. Exposure to mu-opioid receptor agonists such as heroin increases expression of the prodynorphin gene (PDYN) in the brain. In this study in a Caucasian cohort, we examined the association of the functional PDYN 68-bp repeat polymorphism with opioid use disorders. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.038DOI Listing
March 2019
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Distribution, nature, and origin of CXCL14-immunoreactive fibers in rat parotid gland.

Neurosci Lett 2019 Mar 28;704:21-27. Epub 2019 Mar 28.

Brain Functions and Neuroscience Division, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, Inaoka-cho 82, Yokosuka, Kanagawa 238-8580, Japan. Electronic address:

The distribution and nature of CXCL14-immunoreactive nerve fibers in salivary glands, especially the parotid gland was immunohistochemically investigated. Furthermore, the origin of parotid CXCL14-immunoreactive nerve fibers was determined by retrograde tracing experiments. CXCL14-immunoreactive nerve fibers were localized in the parotid, submandibular, and sublingual glands, particularly in the parotid gland. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193019
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http://dx.doi.org/10.1016/j.neulet.2019.03.037DOI Listing
March 2019
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Lysosome exocytosis is involved in astrocyte ATP release after oxidative stress induced by HO.

Neurosci Lett 2019 Mar 27. Epub 2019 Mar 27.

Shanghai JiaoTong Affiliated Sixth People's Hospital, School of Medicine, Neuroscience and Neuroengineering Research Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China. Electronic address:

Background And Purpose: Studies demonstrated that oxidative damage decreased intracellular ATP level in astrocytes. However, the pathway mediated ATP level decrease is obscure. Our previous study found intracellular ATP could be released via lysosome exocytosis in astrocytes. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.046DOI Listing
March 2019
1 Read