33,246 results match your criteria Neuroscience Letters [Journal]


Methamphetamine regulates βAPP PROCESSING in human neuroblastoma cells.

Neurosci Lett 2019 Feb 13. Epub 2019 Feb 13.

Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand; Centre National de la Recherche Scientifique, 2 rue Michel Ange, 75016, Paris, France. Electronic address:

Methamphetamine is a potent and highly addictive psychostimulant whose abuse has turned out to be a global health hazard. The multitudinous effects it exerts at the cellular level induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Strikingly, brain changes, tissue damage and neuropsychological symptoms due to Meth exposure compels and necessitates to link the probability of risk of developing premature Alzheimer's disease, a progressive neurodegenerative disorder characterized by amyloid plaques composed of amyloid-β peptides and clinical dementia. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.023DOI Listing
February 2019

Theta-gamma Coupling in the Prelimbic Area is Associated with Heroin Addiction.

Neurosci Lett 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychology & key Laboratory of Psychological Assessment and Rehabilitation for Exceptional Children, Lingnan Normal University, Zhanjiang 524048, China. Electronic address:

The medial prefrontal cortex (mPFC) is implicated in the regulation of drug-seeking behavior, but the specific contributions of the mPFC prelimbic (PL) subdivision and the precise mechanisms underlying heroin abuse remain largely unclear. In the present study, we examined changes in the rhythmic ensemble activity of PL neurons after induction of heroin addiction in rats. Rats were injected daily with saline (control group) or heroin (addiction group) in the light chamber of a light-dark shuttle box, and a video tracking system was used to measure conditioned place preference (CPP) as a sign of addiction. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.020DOI Listing
February 2019

Exploring the neural correlates of the reversed letter effect: evidence from left and right parietal patients.

Neurosci Lett 2019 Feb 11. Epub 2019 Feb 11.

Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy; NeuroTeam Life and Science, Palermo, Italy; IRCCS Santa Lucia Foundation, Rome, Italy.

To investigate the hemispheric lateralization of attentional processes during visual search tasks depending on the stimulus material embedding the target, twelve patients with unilateral left (n = 7) or right (n = 5) parietal lesions and 20 age and education matched healthy controls (HC) were recruited. We used a visual search task for a uniquely tilted oblique bar embedded in an object shape 'N' or in its mirror reversal 'И'. The accuracy and the averaged reaction times (RTs) in each stimulus type ('N' or 'И') were analysed. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.017DOI Listing
February 2019

Glutaminergic tonic action potentiate MPP-induced hydroxyl radical production in rat striatum.

Authors:
Toshio Obata

Neurosci Lett 2019 Feb 11. Epub 2019 Feb 11.

Faculty of Health Sciences, Osaka Aoyama University, 2-11-1 Niina, Mino City, Japan; Pharmacology and Therapeutics, Oita Medical University, Japan. Electronic address:

The effect of glycine on 1-methyl-4-phenylpyridinium ion (MPP)-induced hydroxyl radical (•OH) formation in the extracellular fluid of rat striatum were investigated. Rats were anesthetized and sodium salicylate in Ringer's solution (0.5 nmol/μl/min) was infused through a microdialysis probe to detect the generation of •OH as reflected by the non-enzymatic formation of 2,3-dihydroxybenzoic acid (2,3-DHBA) in rat striatum. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.019DOI Listing
February 2019

Vitamin D receptor polymorphisms and the susceptibility of Parkinson's disease.

Neurosci Lett 2019 Feb 11. Epub 2019 Feb 11.

Department of Infection Control, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Epidemiological evidence concerning the association between vitamin D receptor (VDR) polymorphisms, including rs2228570, rs731236, rs7975232, rs1544410 and Parkinson's disease (PD) risk is inconsistent. A meta-analysis was performed to evaluate these associations via searching PubMed and EMBASE databases up to Jan 4, 2019. Odds ratio (OR) with 95% confidence interval (CI) were applied to assess the strength of these associations. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.018DOI Listing
February 2019
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γ-Secretase and its modulators: twenty years and beyond.

Authors:
Weiming Xia

Neurosci Lett 2019 Feb 11. Epub 2019 Feb 11.

Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Building 70, Room 202, Bedford, MA, 01730, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States. Electronic address:

Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer's presenilin protein that constitute the active site of the γ-secretase complex. Mutations in the genes encoding amyloid precursor protein (APP) or presenilin (PS) cause early onset familial Alzheimer's disease (AD), and sequential cleavages of the APP by β-secretase and γ-secretase/presenilin generate amyloid β protein (Aβ), the major component of pathological hallmark, neuritic plaques, in brains of AD patients. Therapeutic strategies centered on targeting γ-secretase/presenilin to reduce amyloid were implemented and led to several high profile clinical trials. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.011DOI Listing
February 2019

Modulation of tonic immobility by GABAA and GABAB receptors of the medial amygdala.

Neurosci Lett 2019 Feb 10;699:189-194. Epub 2019 Feb 10.

Department of Psychology, School of Philosophy, Science and Literature of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-901, SP, Brazil. Electronic address:

Tonic immobility (TI) is a temporary state of profound motor inhibition associated with great danger as the attack of a predator. Previous studies carried out in our laboratory evidenced high Fos-IR in the posteroventral region of the medial nucleus of the amygdala (MEA) after induction of the TI response. Here, we investigated the effects of GABA and GABA of the MEA on TI duration. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.054DOI Listing
February 2019

Fastigial nucleus electrostimulation promotes axonal regeneration after experimental stroke via cAMP/PKA pathway.

Neurosci Lett 2019 Feb 10;699:177-183. Epub 2019 Feb 10.

Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, 250014, Jinan, Shandong Province, China. Electronic address:

Axon regeneration after cerebral ischemia in mammals is inadequate to restore function, illustrating the need to design better strategies for improving outcomes. Improvement of axon regeneration has been achieved through fastigial nucleus electrostimulation (FNS) in animal researches. However, the mechanisms underlying this neuroprotection remain poorly understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193009
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http://dx.doi.org/10.1016/j.neulet.2019.02.016DOI Listing
February 2019
2 Reads

Simple surface EMG recording as a noninvasive screening method for the detection of acute oxaliplatin-induced neurotoxicity: a feasibility pilot study.

Neurosci Lett 2019 Feb 10;699:184-188. Epub 2019 Feb 10.

Donders Institute for Brain Cognition and Behavior, Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands.

Objectives: Oxaliplatin-induced neurotoxicity can be a dose-limiting side effect to effective chemotherapy. Acute hyperexcitability causes cold-evoked sensory and motor symptoms, which resemble neuromyotonia. An accessible and non-invasive technique for early detection could help select patients for potential treatments. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.014DOI Listing
February 2019
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Differences in brain signal complexity between experts and novices when solving conceptual science problem: a functional near-infrared spectroscopy study.

Neurosci Lett 2019 Feb 10;699:172-176. Epub 2019 Feb 10.

Key Laboratory of Child Development and Learning Science (Ministry of Education), Southeast University, Nanjing 210096, China; Research Center for Learning Science, Southeast University, Nanjing 210096, China; School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. Electronic address:

Assessing the result of conceptual change (i.e., whether an individual has come to correctly understand a science concept) is important in science education, however traditional assessment methods lack objectivity. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.015DOI Listing
February 2019

Effects of microencapsulated olfactory ensheathing cell transplantation on neuropathic pain and P2X7 receptor expression in the L4-5 spinal cord segment.

Neurosci Lett 2019 Feb 9. Epub 2019 Feb 9.

Department of Anatomy, Basic Medical School, Jinggangshan University, Jian City, Jiangxi Province, China; Department of Anatomy, Basic Medical School, Nanchang University, Nanchang City, Jiangxi province, China; 2018 Grade of Tongji University Medical School of Graduate School, Tongji University, Shanghai City, China. Electronic address:

Objectives: The aim of this study was to determine the role of microencapsulated olfactory ensheathing cell (MC-OEC) transplantation in rats with sciatic nerve injury-induced pain, and its relationship with P2 × 7 receptor expression in the L4-5 spinal cord segment.

Methods: Olfactory bulb tissues of healthy Sprague Dawley (SD) rats were collected to culture olfactory ensheathing cells using differential attachment methods. Forty-eight healthy SD rats were randomly assigned to four groups: the sham, chronic constriction injury (CCI), olfactory ensheathing cell (OEC), and MC-OEC groups. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.013DOI Listing
February 2019

Proinflammatory and amyloidogenic S100A9 induced by traumatic brain injury in mouse model.

Neurosci Lett 2019 Feb 10;699:199-205. Epub 2019 Feb 10.

Department of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden. Electronic address:

Traumatic brain injury (TBI) represents a significant risk factor for development of neurodegenerative diseases such as Alzheimer's and Parkinson's. The S100A9-driven amyloid-neuroinflammatory cascade occurring during primary and secondary TBI events can serve as a mechanistic link between TBI and Alzheimer's as demonstrated recently in the human brain tissues. Here by using immunohistochemistry in the controlled cortical impact TBI mouse model we have found pro-inflammatory S100A9 in the brain tissues of all mice on the first and third post-TBI days, while 70% of mice did not show any S100A9 presence on seventh post-TBI day similar to controls. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.012DOI Listing
February 2019
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Δ-Tetrahydrocannabinol elicited 22-kHz ultrasonic vocalization changes after air puff stimulus through CB receptor in adult rats.

Neurosci Lett 2019 Feb 8. Epub 2019 Feb 8.

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Jonan-ku, Fukuoka, 814-0180, Japan.

Δ-Tetrahydrocannabinol (THC) is known to have various pharmacological effects mediated through activation of cannabinoid CB and CB receptors in rodents. In adult rats, 22- and 50-kHz ultrasonic vocalizations (USVs) serve as an effective communication system and as indicators of negative and positive states, respectively. The present study was performed to determine whether THC affects USVs in adult rats, and to determine the roles of cannabinoid receptors in these effects. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.010DOI Listing
February 2019

Identification of a Novel Variant of Golli Myelin Basic Protein BG21 in the Uniquely Neuroprotective White-Footed Mouse.

Neurosci Lett 2019 Feb 8. Epub 2019 Feb 8.

D'Youville College, 320 Porter Ave, Buffalo, NY, 14201, U.S.A. Electronic address:

The myelin basic protein (MBP) gene is a complex gene which codes for several distinct forms of MBP. The various forms of MBP are functionally involved in the development of the nervous system, T-cell regulation, and myelination. Several neurological disorders have been linked to MBP abnormality, further demonstrating its functional significance in the nervous system. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.006DOI Listing
February 2019

Pubertal hormones increase hippocampal expression of α4βδ GABA receptors.

Neurosci Lett 2019 Feb 8. Epub 2019 Feb 8.

Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, 11203, USA. Electronic address:

CA1 hippocampal expression of α4βδ GABA receptors (GABARs) increases at the onset of puberty in female mice, an effect dependent upon the decline in hippocampal levels of the neurosteroid THP (3α-OH-5α-pregnan-20-one) which occurs at this time. The present study further characterized the mechanisms underlying α4βδ expression, assessed in vivo. Blockade of pubertal levels of 17β-estradiol (E) (formestane, 0. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.005DOI Listing
February 2019

Cochlear ablation in neonatal rats disrupts inhibitory transmission in the medial nucleus of the trapezoid body.

Neurosci Lett 2019 Feb 8;699:145-150. Epub 2019 Feb 8.

Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4 - Krc, Czech Republic. Electronic address:

Inhibitory circuits in the auditory brainstem undergo multiple postnatal changes that are both activity-dependent and activity-independent. We tested to see if the shift from GABA- to glycinergic transmission, which occurs in the rat medial nucleus of the trapezoid body (MNTB) around the onset of hearing, depends on sound-evoked neuronal activity. We prevented the activity by bilateral cochlear ablations in early postnatal rats and studied ionotropic GABA and glycine receptors in MNTB neurons after hearing onset. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.058DOI Listing
February 2019

Effects of self-locomotion on the activity of place cells in the hippocampus of a freely behaving monkey.

Neurosci Lett 2019 Feb 7. Epub 2019 Feb 7.

Department of Integrative Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. Electronic address:

The activity of hippocampal cell assemblies is considered to function as the neural substrate for a cognitive map in various animal species. The firing rate of hippocampal place cells increases when an individual animal reaches a specific location in an environment. Although cumulative views on place cells have been revealed by studies using rodents under free-behavior conditions, few studies have addressed the spatial representation provided by hippocampal neurons in primates. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.009DOI Listing
February 2019

Immune cell neural interactions and their contributions to sickle cell disease.

Neurosci Lett 2019 Feb 7;699:167-171. Epub 2019 Feb 7.

Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

Sickle cell disease (SCD) is characterized by hemolysis, inflammation, and pain. Mechanisms of pain manifestation are complex, and there is a major gap in knowledge of how the nervous and immune systems interact to contribute to pain and other comorbidities in SCD. Sterile inflammation in the periphery and central nervous system contributes to vascular and neural activation. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.008DOI Listing
February 2019
2 Reads

Cerebral tissue pO response to stimulation is preserved with age in awake mice.

Neurosci Lett 2019 Feb 7;699:160-166. Epub 2019 Feb 7.

Biomedical Engineering Institute, École Polytechnique de Montréal, Montréal, QC, Canada; Montreal Heart Institute, Montréal, QC, Canada. Electronic address:

Compromised oxygen supply to cerebral tissue could be an important mechanism contributing to age-related cognition decline. We recently showed in awake mice that resting cerebral tissue pO decreases with age, a phenomenon that manifests mainly after middle-age. To extend these findings, here we aimed to study how tissue pO response to neuronal stimulation is affected by aging. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.007DOI Listing
February 2019
1 Read

Acute liver failure increases kynurenic acid production in rat brain via changes in tryptophan metabolism in the periphery.

Neurosci Lett 2019 Feb 6. Epub 2019 Feb 6.

Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka Hikone, Shiga 522-8533, Japan. Electronic address:

The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor and N-methyl-d-aspartic acid receptor at endogenous brain concentrations. Recent studies have suggested that increased brain KYNA levels are involved in psychiatric disorders such as schizophrenia and depression. Most of the brain kynurenine (KYN), the KYNA precursor, comes from the periphery, and the liver has a central role in the peripheral tryptophan metabolism. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.004DOI Listing
February 2019
1 Read

FAM81A protein, a novel component of the postsynaptic density in adult brain.

Neurosci Lett 2019 Feb 5;699:122-126. Epub 2019 Feb 5.

EM Facility, NINDS, NIH, Bethesda, MD, United States.

Analysis of affinity-purified PSD-95 complexes had previously identified a 'hypothetical protein', product of the gene FAM81A [1]. The present study examined the tissue and subcellular distribution of FAM81A protein and its expression levels during development. Comparison of different organs indicates selective expression of FAM81A protein in brain. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.003DOI Listing
February 2019

Cell-permeable p38 MAP kinase protects adult hippocampal neurons from cell death.

Neurosci Lett 2019 Feb 5;699:115-121. Epub 2019 Feb 5.

Department of Physiology, Toho University Graduate School of Medicine, 143-8540, Tokyo, Japan; Department of Physiology, Toho University School of Medicine, 143-8540, Tokyo, Japan.

p38 mitogen-activated protein (MAP) kinase (p38) is a member of the MAP kinase family. Previous reports using p38 chemical inhibitors have suggested that its activation contributes to hippocampal neuronal cell death rather than cell survival. In this study, we used both a cell-permeable p38 protein containing the HIV protein transduction domain (PTD) and cultured adult hippocampal neurons, which were differentiated from cultured adult hippocampal neural stem/progenitor cells (NPCs), to evaluate the direct function of p38 on adult hippocampal neurons. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.002DOI Listing
February 2019

NMDA receptor deletion on dopamine neurons disrupts visual discrimination and reversal learning.

Neurosci Lett 2019 Feb 3;699:109-114. Epub 2019 Feb 3.

Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

The dopamine (DA) system is critical for various forms of learning about salient environmental stimuli. Prior work has shown that deletion of the obligatory NR1 subunit of the N-methyl--aspartate (NMDA) receptor on neurons expressing the DA transporter (DAT) in mice results in reduced phasic release from DA-containing neurons. To further investigate the contribution of phasic DA release to reward-related learning and cognitive flexibility, the current study evaluated DAT-NR1 null mutant mice in a touchscreen-based pairwise visual discrimination and reversal learning paradigm. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.001DOI Listing
February 2019
1 Read

Corrigendum to "Enriched environment promotes remyelination and motor function recovery through modulation of HDAC1/2 in mice" [Neurosci. Lett. 655 (August) (2017) 121-130].

Neurosci Lett 2019 Feb 1;694:240-241. Epub 2019 Feb 1.

School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.01.038DOI Listing
February 2019

Effects of agomelatine in rotenone-induced Parkinson's disease in rats.

Neurosci Lett 2019 Feb 1;699:71-76. Epub 2019 Feb 1.

Ondokuz Mayıs University, Medical Faculty, Department of Pharmacology, Turkey. Electronic address:

The effects of melatonin and melatonin analogs in experimental Parkinson's disease (PD) models remain controversial. Agomelatine, a novel analog of melatonin, is both agonists for melatonin-1 and melatonin-2 receptors and antagonist of 5-HTC receptors. While agomelatine has been commonly used as an anti-depressant and sleep drug, information about effects of agomelatine in PD are still lacking. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.057DOI Listing
February 2019
1 Read
2.055 Impact Factor

Homozygosity for the A431E mutation in PSEN1 presenting with a relatively aggressive phenotype.

Neurosci Lett 2019 Feb 1;699:195-198. Epub 2019 Feb 1.

Department of Neurology, Keck School of Medicine at USC, United States. Electronic address:

Objective: We report a 35 year-old male with childhood learning disability and early onset dementia who is homozygous for the A431E variant in the PSEN1 gene. Presenilin1 mutations are associated with autosomal dominant Alzheimer's dementia with young and somewhat stereotyped onset. Such variants may cause Alzheimer's dementia through aberrant processing of amyloid precursor protein through effects on γ-secretase activity. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.047DOI Listing
February 2019
1 Read

Ketamine induces central antinociception mediated by endogenous cannabinoids and activation of CB receptors.

Neurosci Lett 2019 Feb 1;699:140-144. Epub 2019 Feb 1.

Department of Pharmacology, Institute of Biological Sciences, UFMG, Av. Antônio Carlos, 6627, 31.270.100, Belo Horizonte, Brazil. Electronic address:

The participation of endocannabinoids in central and peripheral antinociception induced by several compounds has been shown by our group. In this study, we investigated the effect of endocannabinoids on the central antinociception induced by ketamine. The nociceptive threshold for thermal stimulation was measured using the tail-flick test in Swiss mice. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.059DOI Listing
February 2019

Activation of the MAPK signaling pathway induces upregulation of pro-apoptotic proteins in the hippocampi of cold stressed adolescent mice.

Neurosci Lett 2019 Jan 31;699:97-102. Epub 2019 Jan 31.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, PR China. Electronic address:

Stress induces many non-specific responses in the hippocampus, especially during adolescence. Low environmental temperature is known to induce stress, but its influence on the hippocampus, especially in adolescent mice is not clear. We compared apoptotic-related protein levels and MAPK signaling pathway activation in hippocampal neurons of adolescent mice under low temperature conditions (4 °C for 12 h) with western blotting and immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.neulet.2018.12.028DOI Listing
January 2019

Identification of β-synuclein on secretory granules in chromaffin cells and the effects of α- and β-synuclein on post-fusion BDNF discharge and fusion pore expansion.

Neurosci Lett 2019 Jan 31;699:134-139. Epub 2019 Jan 31.

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address:

α-Synuclein is strongly implicated in the pathogenesis of Parkinson's disease as well as in other neurodegenerative diseases. However, its normal function in cells is not understood. The N-termini of α-, β-, and γ-synuclein contains six to seven 11-amino acid repeats that are predicted to form amphipathic helices. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.056DOI Listing
January 2019

Altered beta-band functional connectivity may be related to 'performance slowing' in good outcome aneurysmal subarachnoid patients.

Neurosci Lett 2019 Jan 31;699:64-70. Epub 2019 Jan 31.

Neurosciences and Mental Health, SickKids Research Institute, Toronto, Canada; Division of Neurology, The Hospital for Sick Children, University of Toronto, Canada. Electronic address:

Recent evidence suggests that good neurological outcome in subarachnoid hemorrhage (SAH) does not equate to good neuropsychological and cognitive outcome. These individuals continue to face cognitive difficulties in tasks involving mental flexibility, short-term memory and attention, resulting in decreased independence in daily living and reduced ability to return to work. In the current study, we examined the functional connectivity profiles using magnetoencephalography (MEG) in SAH patients, versus controls, during a visual short-term memory, 1-back, task. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.053DOI Listing
January 2019
1 Read

The effect of coil type and limb dominance in the assessment of lower-limb motor cortex excitability using TMS.

Neurosci Lett 2019 Jan 30;699:84-90. Epub 2019 Jan 30.

Brain and Mind Centre, University of Sydney, Sydney, NSW, 2050, Australia; Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia.

Purpose: Clinical application of transcranial magnetic stimulation (TMS) has rapidly increased but the majority of studies have targeted upper limb muscles, with few exploring the lower-limb. Differences of coil choice have added to methodological difficulties of lower-limb studies and have challenged consistent interpretation of these parameters. The aims of this study were to determine the optimal coil choice for assessing lower-limb cortical excitability and assess laterality of normal cortical function. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.050DOI Listing
January 2019

Lack of Analgesic Effects of Transcranial Pulsed Electromagnetic Field Stimulation in Neuropathic Pain Patients: A Randomized Double-Blind Crossover Trial.

Neurosci Lett 2019 Jan 30. Epub 2019 Jan 30.

University of Groningen, University Medical Center Groningen, Department of Neuroscience, Groningen, the Netherlands.

Background: Neuromodulation is nowadays investigated as a promising method for pain relief. Research indicates that a single 30-minute stimulation with transcranial pulsed electromagnetic fields (tPEMF) can induce analgesic effects. However, it is unknown whether tPEMF can induce analgesia in neuropathic pain patients. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.051DOI Listing
January 2019

Gait phase proportions in different locomotion tasks: The pivot role of golden ratio.

Neurosci Lett 2019 Jan 30;699:127-133. Epub 2019 Jan 30.

IRCCS Fondazione Santa Lucia, Italy.

Walking is a repeatable and cyclic locomotor act, presenting standardized biomechanical patterns within the gait cycle in healthy humans. Specifically, both stance and swing durations exhibit high reliability at comfortable speed, maintaining the same proportion between the twos with respect to different contextual features in forward walking. Recently, it was found that this proportion is close to the "golden ratio" (a well-known irrational number equal to 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193007
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http://dx.doi.org/10.1016/j.neulet.2019.01.052DOI Listing
January 2019
1 Read

Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats.

Neurosci Lett 2019 Jan 30;699:77-83. Epub 2019 Jan 30.

Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China. Electronic address:

Prenatal alcohol exposure (PAE) could lead to developmental disorders of the central nervous system (CNS) and mental retardation. Toll-like receptor (TLR) 4 plays an important role in PAE-induced neurodevelopmental defects. However, how PAE affects TLR4 response in the brain remains controversial. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.049DOI Listing
January 2019
2 Reads

Spinal macrophage migration inhibitory factor and high mobility group box 1 mediate persistent bladder pain.

Neurosci Lett 2019 Jan 29;699:54-58. Epub 2019 Jan 29.

Research and Development, Lexington Veterans Affairs Health Care System, Lexington, KY, United States; Department of Physiology, University of Kentucky, Lexington, KY, United States. Electronic address:

Repeated intravesical PAR4 (protease activated receptor 4) activation elicits persistent bladder pain lasting 5 days after the last treatment. Persistent bladder pain was fully reversed by a systemic HMGB1 (high mobility group box 1) inhibitor while a MIF (macrophage migration inhibitory factor) antagonist partly reversed it. Since there is growing evidence that spinal MIF and HMGB1 mediate inflammatory and neuropathic pain we examined whether there were spinal changes occurring during persistent bladder pain that may be responsible for maintaining bladder pain. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.046DOI Listing
January 2019
1 Read

Proteomic profiling reveals Arl6ip-1 as a candidate target in cancer-induced bone pain rat model after oxycodone treatment.

Neurosci Lett 2019 Jan 29;699:151-159. Epub 2019 Jan 29.

Department of Anesthesiology and Pain Medicine, The First Affiliated Hospital of Jiaxing University, Jiaxing, 314001, China. Electronic address:

Treatment of cancer-induced bone pain (CIBP) is challenging in clinics. Oxycodone is used to treat CIBP. However, the lack of understanding of the mechanism of CIBP limits the application of oxycodone. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.045DOI Listing
January 2019

Maternal-Induced Shifts in Allostatic Demands: Reproductive Experience Alters Emotional and Cognitive Biobehavioral Responses in Rats (Rattus norvegicus).

Neurosci Lett 2019 Jan 29. Epub 2019 Jan 29.

Dept of Psychology, Neuroscience Concentration, University of Richmond, VA, 23173, USA. Electronic address:

The arrival and subsequent care of offspring require abrupt shifts in biobehavioral responses in mammalian mothers. In the current study, female rats with one reproductive experience [primiparous (PRIM) rats, n = 8] or no reproductive experience [nulliparous (NULL) rats, n = 8] were assessed in a dry land maze to determine both learning acquisition and responses to uncertainty/prediction errors during the probe trial. Additionally, rats were observed in a swim task and an open field arena to assess responsiveness to varied environmental challenges. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.048DOI Listing
January 2019
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Changes in ERK1/2 phosphorylation in the rat striatum and medial prefrontal cortex following administration of the adenosine A receptor agonist and antagonist.

Neurosci Lett 2019 Jan 28;699:47-53. Epub 2019 Jan 28.

Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA; Department of Anesthesiology, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA. Electronic address:

The extracellular signal-regulated kinase (ERK) is enriched in the central nervous system, including the dopamine responsive regions such as the striatum and medial prefrontal cortex (mPFC). The kinase is sensitive to changing cellular and synaptic input and is implicated in the regulation of synaptic transmission and plasticity. In this study, the role of a G protein-coupled adenosine A receptor in the regulation of ERK1/2 was investigated in the rat brain in vivo. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.044DOI Listing
January 2019
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Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.

Neurosci Lett 2019 Jan 25;699:103-108. Epub 2019 Jan 25.

Department of Drug analysis, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka, Fukuoka, 815-8511, Japan. Electronic address:

Sinomenine, an alkaloid originally isolated from the roots and the rhizome of Sinomenium acutum is used as a traditional Chinese herbal medicines for rheumatoid arthritis and neuralgia. The aims of this study were to investigate the effects of oral administration of shinomenine on formalin-induced nociceptive behavior in mice and the opioid receptor subtypes involved in the antinociceptive effects of sinomenine. Our findings showed that a single dose of oral-administrated sinomenine inhibited the formalin induced licking and biting responses in a dose-dependent manner. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.035DOI Listing
January 2019

Effect of photoperiodic alterations on depression-like behavior and the brain serotonin system in mice genetically different in tryptophan hydroxylase 2 activity.

Neurosci Lett 2019 Jan 24;699:91-96. Epub 2019 Jan 24.

Department of Genetic Models of Neurological Disorders, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, 630090, Russia.

Reduction of natural illumination in fall/winter months causes seasonal affective disorders (SAD) in vulnerable individuals. Neurotransmitter serotonin (5-HT) is involved in the mechanism of SAD. Tryptophan hydroxylase-2 (TPH2) is the key enzyme of 5-HT synthesis in the brain. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.041DOI Listing
January 2019
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Human iPSC application in Alzheimer's disease and Tau-related neurodegenerative diseases.

Authors:
Julia Tcw

Neurosci Lett 2019 Jan 24;699:31-40. Epub 2019 Jan 24.

Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Icahn school of Medicine at Mount Sinai, New York, USA. Electronic address:

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by β-amyloid (Aβ) plaques and neurofibrillary tangles with progressive cognitive decline. After years of research with failed clinical trials surrounding Aβ and tau using numerous in vitro and in vivo AD transgenic animals, human model is necessary to advance our understanding of AD and drug discovery. Induced pluripotent stem cells (iPSCs) offers a novel approach for the establishment of a human model that reflects human genetics and physiology to investigate mechanisms of AD and other forms of dementia, which potentially could lead to a drug discovery, followed by treatment for the disease. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.043DOI Listing
January 2019
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Alpha band signatures of social synchrony.

Neurosci Lett 2019 Jan 23;699:24-30. Epub 2019 Jan 23.

Eunice Kennedy Shriver Center, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA.

Previous research has reported changes in mu rhythm, the central rhythm of the alpha frequency band, in both intentional and spontaneous interpersonal coordination. The current study was designed to extend existing findings on social synchrony to the pendulum swinging task and simultaneously measured time unfolding behavioral synchrony and EEG estimation of mu activity during spontaneous, intentional in-phase and intentional anti-phase interpersonal coordination. As expected, the behavioral measures of synchrony demonstrated the expected pattern of weak synchronization for spontaneous coordination, moderate synchronization for intentional anti-phase coordination, and strong synchronization for in-phase coordination. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.037DOI Listing
January 2019

Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson's disease patients.

Neurosci Lett 2019 Jan 23;699:59-63. Epub 2019 Jan 23.

Department of Neurology, Graduate school of Medicine, Juntendo University, Tokyo, 113-8421, Japan.

Parkinson's disease (PD) is the second most common neurodegenerative disease. Lewy bodies and pale bodies in dopaminergic neurons in the substantia nigra are pathological hallmarks of PD. A number of neurodegenerative diseases demonstrate aggregate formation, but how these aggregates are associated with their pathogenesis remains unknown. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.042DOI Listing
January 2019
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Impaired fear memory extinction during adolescence is accompanied by the depressive-like behaviors.

Neurosci Lett 2019 Jan 24;699:8-15. Epub 2019 Jan 24.

Department of Traumatic Orthopedics, Zhengzhou Orthopaedics Hospital, Zhengzhou 450052, China. Electronic address:

Fear is the emotion that is best understood in terms of brain mechanisms. And the management of fear memories is important when facing mental health disorders such as post-traumatic stress. Adolescence is a transitional stage of physical and psychological human development and the ability to deal with the fear memory in adolescence may be a potent factor for developing mental disorders in adulthood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193004
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http://dx.doi.org/10.1016/j.neulet.2019.01.039DOI Listing
January 2019
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Facial Emotion Recognition in Deaf Children: Evidence from Event-related Potentials and Event-related Spectral Perturbation Analysis.

Neurosci Lett 2019 Jan 21. Epub 2019 Jan 21.

Department of Health Promotion, Education, and Behavior, University of South Carolina, United States.

Impairment of facial emotion recognition ability has been reported in deaf children, but few researches have examined the neural mechanism of this impairment. This study applied the electroencephalogram (EEG) technique to investigate the emotion recognition ability in 31 deaf children and 30 hearing controls with facial emotion recognition task. Results from behavioral task showed that deaf children exhibited lower accuracy compared to hearing controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940193004
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http://dx.doi.org/10.1016/j.neulet.2019.01.032DOI Listing
January 2019
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Time course of emotion effects during emotion-label and emotion-laden word processing.

Neurosci Lett 2019 Jan 21;699:1-7. Epub 2019 Jan 21.

College of Education, Shanghai Normal University, Shanghai 200234, China. Electronic address:

Previous studies have investigated the time course of emotion effects during emotion-word processing, but no consistent pattern has emerged. Notably, most of these studies intermixed emotion-label words (e.g. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.028DOI Listing
January 2019

Peripheral nervous system effects in the PS19 tau transgenic mouse model of tauopathy.

Neurosci Lett 2019 Jan 21;698:204-208. Epub 2019 Jan 21.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain; CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Spain. Electronic address:

It is well known that transgenic mice overexpressing human tau protein with P301S mutation driven by the mouse prion protein promoter show clasping and limb retraction, hunched back and paralysis, followed by inability to feed that results in death around 12 months of age. To understand these motor deficits, we have carried out rotarod tests on PS19 line and demonstrated how they worsened during aging. Then, we have analyzed if these phenotypic characteristics correlate with sciatic nerve degeneration. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.031DOI Listing
January 2019
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Long-lasting actions of somatostatin on pyramidal cell excitability in the mouse cingulate cortex.

Neurosci Lett 2019 Jan 19;698:217-223. Epub 2019 Jan 19.

Biomedical Center, Ludwig-Maximilians-Universität, Physiological Genomics, Großhaderner Str. 9, 82152 Planegg-Martinsried, Germany.

Many neurological diseases are related to disturbances of somatostatin- (SOM-) expressing interneurons in the cingulate cortex. Therefore, their role within the circuitry of the cingulate cortex needs to be investigated. We describe here the physiological time course of SOM effects onto pyramidal cell excitability and action potential discharge pattern. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.034DOI Listing
January 2019
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Direct and selective lineage conversion of human fibroblasts to dopaminergic precursors.

Neurosci Lett 2019 Jan 18;699:16-23. Epub 2019 Jan 18.

Department of Pharmacology & Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, 68198, United States; Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital affiliated to Tongji University School of Medicine, Shanghai, China. Electronic address:

Transplantation of dopaminergic precursors (DPs) is a promising therapeutic strategy of Parkinson's disease (PD). However, limited cell source for dopaminergic precursors has become a major obstacle for transplantation therapy. Our group demonstrated previously that mouse fibroblasts can be reprogrammed into induced dopaminergic precursors (iDPs) with high differentiation efficiency. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.033DOI Listing
January 2019
3 Reads