1,040 results match your criteria Neuroscience Bulletin [Journal]


Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses.

Neurosci Bull 2019 Apr 19. Epub 2019 Apr 19.

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal for mapping neural circuits. So far, several classes of viral neuronal tracers have become available and provide a powerful toolbox for delineating neural networks. Read More

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http://dx.doi.org/10.1007/s12264-019-00374-9DOI Listing

Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia.

Neurosci Bull 2019 Apr 12. Epub 2019 Apr 12.

Center for Translational Medicine, Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, 215600, China.

Chronic visceral hypersensitivity is an important type of chronic pain with unknown etiology and pathophysiology. Recent studies have shown that epigenetic regulation plays an important role in the development of chronic pain conditions. However, the role of miRNA-325-5p in chronic visceral pain remains unknown. Read More

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http://dx.doi.org/10.1007/s12264-019-00372-xDOI Listing

MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by Activating Oxidation Resistance 1-Mediated Antioxidant Signals.

Neurosci Bull 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurobiology and Institute for Basic Research on Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.

MicroRNA-365 (miR-365) is upregulated in the ischemic brain and is involved in oxidative damage in the diabetic rat. However, it is unclear whether miR-365 regulates oxidative stress (OS)-mediated neuronal damage after ischemia. Here, we used a transient middle cerebral artery occlusion model in rats and the hydrogen peroxide-induced OS model in primary cultured neurons to assess the roles of miR-365 in neuronal damage. Read More

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http://dx.doi.org/10.1007/s12264-019-00371-yDOI Listing
April 2019
1 Read

High-Throughput Automatic Training System for Spatial Working Memory in Free-Moving Mice.

Neurosci Bull 2019 Apr 11. Epub 2019 Apr 11.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, 200031, China.

Efficient behavioral assays are crucial for understanding the neural mechanisms of cognitive functions. Here, we designed a high-throughput automatic training system for spatial cognition (HASS) for free-moving mice. Mice were trained to return to the home arm and remain there during a delay period. Read More

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http://dx.doi.org/10.1007/s12264-019-00370-zDOI Listing

Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin.

Neurosci Bull 2019 Apr 11. Epub 2019 Apr 11.

State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, 100871, China.

Isolation rearing (IR) enhances aggressive behavior, and the central serotonin (5-hydroxytryptamine, 5-HT) system has been linked to IR-induced aggression. However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2 and Lmx1b, we examined the association between central serotonin and aggression with or without social isolation. Read More

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http://dx.doi.org/10.1007/s12264-019-00373-wDOI Listing
April 2019
1 Read

Pros and Cons: Autophagy in Acute Spinal Cord Injury.

Neurosci Bull 2019 Apr 4. Epub 2019 Apr 4.

Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

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http://link.springer.com/10.1007/s12264-019-00368-7
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http://dx.doi.org/10.1007/s12264-019-00368-7DOI Listing
April 2019
2 Reads

A Novel Prognostic Approach to Predict Recovery in Patients with Chronic Disorders of Consciousness.

Neurosci Bull 2019 Mar 22. Epub 2019 Mar 22.

Department of Neurology, First Affiliated Hospital, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou, 310003, China.

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http://dx.doi.org/10.1007/s12264-019-00369-6DOI Listing
March 2019
1 Read

Medial Preoptic Area Modulates Courtship Ultrasonic Vocalization in Adult Male Mice.

Neurosci Bull 2019 Mar 21. Epub 2019 Mar 21.

Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.

Adult male mice emit highly complex ultrasonic vocalizations (USVs) in response to female conspecifics. Such USVs, thought to facilitate courtship behaviors, are routinely measured as a behavioral index in mouse models of neurodevelopmental and psychiatric disorders such as autism. While the regulation of USVs by genetic factors has been extensively characterized, the neural mechanisms that control USV production remain largely unknown. Read More

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http://link.springer.com/10.1007/s12264-019-00365-w
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http://dx.doi.org/10.1007/s12264-019-00365-wDOI Listing
March 2019
5 Reads

Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain.

Neurosci Bull 2019 Mar 21. Epub 2019 Mar 21.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A (BoNT/A) on depression-like behaviors in mice and to explore the potential mechanisms. These results revealed that a single facial injection of BoNT/A induced a rapid and prolonged improvement of depression-like behaviors in naïve and space-restriction-stressed (SRS) mice, reflected by a decreased duration of immobility in behavioral despair tests. BoNT/A significantly increased the 5-hydroxytryptamine (5-HT) levels in several brain regions, including the hippocampus and hypothalamus, in SRS mice. Read More

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http://dx.doi.org/10.1007/s12264-019-00367-8DOI Listing
March 2019
2 Reads

Rapid and Sparse Labeling of Neurons Based on the Mutant Virus-Like Particle of Semliki Forest Virus.

Neurosci Bull 2019 Mar 19. Epub 2019 Mar 19.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China.

Sparse labeling of neurons contributes to uncovering their morphology, and rapid expression of a fluorescent protein reduces the experiment range. To achieve the goal of rapid and sparse labeling of neurons in vivo, we established a rapid method for depicting the fine structure of neurons at 24 h post-infection based on a mutant virus-like particle of Semliki Forest virus. Approximately 0. Read More

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http://dx.doi.org/10.1007/s12264-019-00362-zDOI Listing
March 2019
1 Read

Rac1 Modulates Excitatory Synaptic Transmission in Mouse Retinal Ganglion Cells.

Neurosci Bull 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Ras-related C3 botulinum toxin substrate 1 (Rac1), a member of the Rho GTPase family which plays important roles in dendritic spine morphology and plasticity, is a key regulator of cytoskeletal reorganization in dendrites and spines. Here, we investigated whether and how Rac1 modulates synaptic transmission in mouse retinal ganglion cells (RGCs) using selective conditional knockout of Rac1 (Rac1-cKO). Rac1-cKO significantly reduced the frequency of AMPA receptor-mediated miniature excitatory postsynaptic currents, while glycine/GABA receptor-mediated miniature inhibitory postsynaptic currents were not affected. Read More

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http://dx.doi.org/10.1007/s12264-019-00353-0DOI Listing
March 2019
1 Read

MicroRNA21 Meets Neuronal TLR8: Non-canonical Functions of MicroRNA in Neuropathic Pain.

Neurosci Bull 2019 Mar 18. Epub 2019 Mar 18.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215021, China.

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http://dx.doi.org/10.1007/s12264-019-00366-9DOI Listing

Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer's Disease.

Neurosci Bull 2019 Mar 18. Epub 2019 Mar 18.

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Synaptic dysfunction and abnormal processing of amyloid precursor protein (APP) are early pathological features in Alzheimer's disease (AD). Recently, non-coding RNAs such as microRNAs (miRNAs) and circular RNAs (circRNAs) have been reported to contribute to the pathogenesis of AD. We found an age-dependent elevation of miR-138 in APP/PS1 (presenilin-1) mice. Read More

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http://dx.doi.org/10.1007/s12264-019-00361-0DOI Listing
March 2019
1 Read

Effect of Apolipoprotein E Genotypes on Huntington's Disease Phenotypes in a Han Chinese Population.

Neurosci Bull 2019 Mar 18. Epub 2019 Mar 18.

Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Huntington's disease (HD) is an autosomal dominant degenerative disease that mainly encompasses movement, cognition, and behavioral symptoms. The apolipoprotein E (APOE) gene is thought to be associated with many neurodegenerative diseases. Here, we enrolled a cohort of 223 unrelated Han Chinese patients with HD and 1241 unrelated healthy controls in Southeastern China and analyzed the correlation between APOE genotypes and HD phenotypes. Read More

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http://dx.doi.org/10.1007/s12264-019-00360-1DOI Listing
March 2019
4 Reads

Selective Targeting of Perirhinal Cortex Projection to Hippocampal CA1 Interneurons.

Neurosci Bull 2019 Mar 16. Epub 2019 Mar 16.

State Key Laboratory of Cognitive Neuroscience & Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.

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http://dx.doi.org/10.1007/s12264-019-00363-yDOI Listing

Paraventricular Thalamus as A Major Thalamic Structure for Wake Control.

Neurosci Bull 2019 Mar 16. Epub 2019 Mar 16.

Departments of Neuroscience, Anatomy, Histology, and Embryology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.

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http://dx.doi.org/10.1007/s12264-019-00364-xDOI Listing

Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action.

Neurosci Bull 2019 Mar 11. Epub 2019 Mar 11.

Savaid Medical School, University of the Chinese Academy of Sciences, Beijing, 101408, China.

Accumulating evidence suggests that the circadian rhythm plays a critical role in mood regulation, and circadian disturbances are often found in patients with major depressive disorder (MDD). The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is involved in mediating entrainment of the circadian system. Furthermore, the MAPK/ERK signaling pathway has been shown to be involved in the pathogenesis of MDD and the rapid onset of action of antidepressant therapies, both pharmaceutical and non-pharmaceutical. Read More

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http://link.springer.com/10.1007/s12264-019-00358-9
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http://dx.doi.org/10.1007/s12264-019-00358-9DOI Listing
March 2019
2 Reads

A Two-Step GRIN Lens Coating for In Vivo Brain Imaging.

Neurosci Bull 2019 Mar 9. Epub 2019 Mar 9.

Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.

The complex spatial and temporal organization of neural activity in the brain is important for information-processing that guides behavior. Hence, revealing the real-time neural dynamics in freely-moving animals is fundamental to elucidating brain function. Miniature fluorescence microscopes have been developed to fulfil this requirement. Read More

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http://dx.doi.org/10.1007/s12264-019-00356-xDOI Listing
March 2019
1 Read

Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms.

Neurosci Bull 2019 Mar 9. Epub 2019 Mar 9.

Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia. However, the neural mechanisms underlying this association are unknown. Given that ZNF804A upregulates the expression of COMT, we hypothesized that ZNF804A may influence brain activity by interacting with COMT. Read More

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http://dx.doi.org/10.1007/s12264-019-00357-wDOI Listing
March 2019
2 Reads

Abnormal Brain Structure and Function in First-Episode Childhood- and Adolescence-Onset Schizophrenia: Association with Clinical Symptoms.

Neurosci Bull 2019 Mar 9. Epub 2019 Mar 9.

Department of Child and Adolescent Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxaing Medical University, Xinxiang, 453002, China.

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http://link.springer.com/10.1007/s12264-019-00359-8
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http://dx.doi.org/10.1007/s12264-019-00359-8DOI Listing
March 2019
4 Reads

Therapeutic Potential of Glucagon-Like Peptide-1 Cleavage Product for Alzheimer's Disease.

Neurosci Bull 2019 Mar 7. Epub 2019 Mar 7.

Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.

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http://dx.doi.org/10.1007/s12264-019-00355-yDOI Listing
March 2019
1 Read

Progress in Human Brain Banking in China.

Neurosci Bull 2019 Apr 7;35(2):179-182. Epub 2019 Mar 7.

Department Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12264-019-00350-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426891PMC

T188K-Familial Creutzfeldt-Jacob Disease, Predominant Among Chinese, has a Reactive Pattern in CSF RT-QuIC Different from D178N-Fatal Familial Insomnia and E200K-Familial CJD.

Neurosci Bull 2019 Mar 5. Epub 2019 Mar 5.

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s12264-019-00354-zDOI Listing
March 2019
1 Read

More than Scratching the Surface: Recent Progress in Brain Mechanisms Underlying Itch and Scratch.

Neurosci Bull 2019 Mar 4. Epub 2019 Mar 4.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215021, China.

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http://dx.doi.org/10.1007/s12264-019-00352-1DOI Listing

Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function.

Neurosci Bull 2019 Mar 2. Epub 2019 Mar 2.

South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

Rho-associated kinases (ROCKs) are serine-threonine protein kinases that act downstream of small Rho GTPases to regulate the dynamics of the actin cytoskeleton. Two ROCK isoforms (ROCK1 and ROCK2) are expressed in the mammalian central nervous system. Although ROCK activity has been implicated in synapse formation, whether the distinct ROCK isoforms have different roles in synapse formation and function in vivo is not clear. Read More

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http://dx.doi.org/10.1007/s12264-019-00351-2DOI Listing
March 2019
2 Reads

Up-regulation of P2X7 Receptors Contributes to Spinal Microglial Activation and the Development of Pain Induced by BmK-I.

Neurosci Bull 2019 Feb 28. Epub 2019 Feb 28.

Department of Pharmacology and Toxicology and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Previous work has demonstrated that the sensitization of spinal neurons and microglia is important in the development of pain behaviors induced by BmK I, a Na channel activator and a major peptide component of the venom of the scorpion Buthus martensi Karsch (BmK). We found that the expression of P2X7 receptors (P2X7Rs) was up-regulated in the ipsilateral spinal dorsal horn after BmK I injection in rats. P2X7R was selectively localized in microglia but not astrocytes or neurons. Read More

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http://link.springer.com/10.1007/s12264-019-00345-0
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http://dx.doi.org/10.1007/s12264-019-00345-0DOI Listing
February 2019
5 Reads

A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance.

Neurosci Bull 2019 Feb 27. Epub 2019 Feb 27.

Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

When facing a sudden danger or aversive condition while engaged in on-going forward motion, animals transiently slow down and make a turn to escape. The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown. Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons (the PET pathway). Read More

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http://dx.doi.org/10.1007/s12264-019-00349-wDOI Listing
February 2019
1 Read

Enhancement of T Follicular Helper Cell-Mediated Humoral Immunity Reponses During Development of Experimental Autoimmune Myasthenia Gravis.

Neurosci Bull 2019 Feb 22. Epub 2019 Feb 22.

Department of Neurobiology, Heilongjiang Provincial Key Laboratory of Neurobiology, Harbin Medical University, Harbin, 150081, China.

Myasthenia gravis (MG) is a prototypical antibody-mediated neurological autoimmune disease with the involvement of humoral immune responses in its pathogenesis. T follicular helper (Tfh) cells have been implicated in many autoimmune diseases. However, whether and how Tfh cells are involved in MG remain unclear. Read More

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http://dx.doi.org/10.1007/s12264-019-00344-1DOI Listing
February 2019
1 Read

Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia.

Neurosci Bull 2019 Feb 21. Epub 2019 Feb 21.

Mental Health Centre and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.

Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia. Meanwhile, progressive neurodegenerative processes have also been reported, leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia. However, a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures. Read More

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http://dx.doi.org/10.1007/s12264-019-00348-xDOI Listing
February 2019
1 Read

Thymosin Alpha-1 Inhibits Complete Freund's Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord.

Neurosci Bull 2019 Feb 21. Epub 2019 Feb 21.

South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

Activation of inflammatory responses regulates the transmission of pain pathways through an integrated network in the peripheral and central nervous systems. The immunopotentiator thymosin alpha-1 (Tα1) has recently been reported to have anti-inflammatory and neuroprotective functions in rodents. However, how Tα1 affects inflammatory pain remains unclear. Read More

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http://dx.doi.org/10.1007/s12264-019-00346-zDOI Listing
February 2019

Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons.

Neurosci Bull 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Neuroligins (NLs) are postsynaptic cell-adhesion proteins that play important roles in synapse formation and the excitatory-inhibitory balance. They have been associated with autism in both human genetic and animal model studies, and affect synaptic connections and synaptic plasticity in several brain regions. Yet current research mainly focuses on pyramidal neurons, while the function of NLs in interneurons remains to be understood. Read More

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http://dx.doi.org/10.1007/s12264-019-00347-yDOI Listing
February 2019
1 Read

Post-Mortem MRI and Histopathology in Neurologic Disease: A Translational Approach.

Neurosci Bull 2019 Apr 21;35(2):229-243. Epub 2019 Feb 21.

Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.

In this review, combined post-mortem brain magnetic resonance imaging (MRI) and histology studies are highlighted, illustrating the relevance of translational approaches to define novel MRI signatures of neuropathological lesions in neuroinflammatory and neurodegenerative disorders. Initial studies combining post-mortem MRI and histology have validated various MRI sequences, assessing their sensitivity and specificity as diagnostic biomarkers in neurologic disease. More recent studies have focused on defining new radiological (bio)markers and implementing them in the clinical (research) setting. Read More

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http://dx.doi.org/10.1007/s12264-019-00342-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426886PMC
April 2019
1 Read

Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese.

Neurosci Bull 2019 Apr 19;35(2):193-204. Epub 2019 Feb 19.

Institute of Basic Medical Sciences, Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.

In this study, the distribution of five Alzheimer's disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs, clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College (CAMS/PUMC) Human Brain Bank. APOE ε4 (OR = 4. Read More

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http://dx.doi.org/10.1007/s12264-019-00343-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426929PMC
April 2019
3 Reads

MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells.

Neurosci Bull 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience of the Ministry of Education and National Health and Family Planning Commission, Neuroscience Research Institute, Peking University, Beijing, 100191, China.

MicroRNA-132 (miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain. Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells (NSCs) and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration (MSA) model. Read More

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http://dx.doi.org/10.1007/s12264-019-00338-zDOI Listing
February 2019
1 Read

Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies.

Neurosci Bull 2019 Apr 5;35(2):253-266. Epub 2019 Feb 5.

Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Alzheimer's disease (AD) is characterized by decreased neuronal activity and atrophy, while hyperactivity of neurons seems to make them resistant to aging and neurodegeneration, a phenomenon which we have paraphrased as 'use it or lose it'. Our hypothesis proposes that (1) during their functioning, neurons are damaged; (2) accumulation of damage that is not repaired is the basis of aging; (3) the vulnerability to AD is determined by the genetic background and the balance between the amount of damage and the efficiency of repair, and (4) by stimulating the brain, repair mechanisms are stimulated and cognitive reserve is increased, resulting in a decreased rate of aging and risk for AD. Environmental stimulating factors such as bilingualism/multilingualism, education, occupation, musical experience, physical exercise, and leisure activities have been reported to reduce the risk of dementia and decrease the rate of cognitive decline, although methodological problems are present. Read More

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http://dx.doi.org/10.1007/s12264-019-00340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426905PMC
April 2019
6 Reads

Quantification of Tyrosine Hydroxylase and ErbB4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin.

Neurosci Bull 2019 Apr 31;35(2):205-215. Epub 2019 Jan 31.

Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

The locus coeruleus (LC) has been studied in major depressive disorder (MDD) and bipolar disorder (BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown pigment neuromelanin. Here, we used a multispectral method to untangle the two colors: blue immunocytochemical staining and brown neuromelanin. Read More

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http://dx.doi.org/10.1007/s12264-019-00339-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426904PMC
April 2019
1 Read

Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice.

Neurosci Bull 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Epilepsy is a chronic and severe neurological disorder that has negative effects on the autonomous activities of patients. Functionally, Trem2 (triggering receptor expressed on myeloid cells-2) is an immunoglobulin receptor that affects neurological and psychiatric genetic diseases. Based on this rationale, we aimed to assess the potential role of Trem2 integration with the PI3K/Akt pathway in epilepsy. Read More

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http://link.springer.com/10.1007/s12264-018-0324-5
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http://dx.doi.org/10.1007/s12264-018-0324-5DOI Listing
January 2019
7 Reads

Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice.

Neurosci Bull 2019 Jan 25. Epub 2019 Jan 25.

Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.

The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas of demyelination. Thus, promoting the differentiation of OPCs is vital for the treatment of demyelinating diseases. Shikimic acid (SA) is mainly derived from star anise, and is reported to have anti-influenza, anti-oxidation, and anti-tumor effects. Read More

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http://dx.doi.org/10.1007/s12264-018-0322-7DOI Listing
January 2019
1 Read

Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats.

Neurosci Bull 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurosurgery, The Second People's Hospital of Liaocheng, Linqing, 252601, China.

Gastrodin is a phenolic glycoside that has been demonstrated to provide neuroprotection in preclinical models of central nervous system disease, but its effect in subarachnoid hemorrhage (SAH) remains unclear. In this study, we showed that intraperitoneal administration of gastrodin (100 mg/kg per day) significantly attenuated the SAH-induced neurological deficit, brain edema, and increased blood-brain barrier permeability in rats. Meanwhile, gastrodin treatment significantly reduced the SAH-induced elevation of glutamate concentration in the cerebrospinal fluid and the intracellular Ca overload. Read More

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http://dx.doi.org/10.1007/s12264-018-00333-wDOI Listing
January 2019
7 Reads

Autonomic Regulation of the Cardiovascular System: Diseases, Treatments, and Novel Approaches.

Neurosci Bull 2019 Feb 19;35(1):1-3. Epub 2019 Jan 19.

Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931-1200, USA.

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http://dx.doi.org/10.1007/s12264-019-00337-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357280PMC
February 2019

Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems.

Neurosci Bull 2019 Jan 18. Epub 2019 Jan 18.

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, 100083, China.

Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g. Read More

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http://dx.doi.org/10.1007/s12264-018-00331-yDOI Listing
January 2019
3 Reads

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Neurosci Bull 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of the Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer's disease (AD), and insulin-resistance is commonly seen in patients with Hhcy. Liraglutide (Lir), a glucagon-like peptide that increases the secretion and sensitivity of insulin, has a neurotrophic or neuroprotective effect. However, it is not known whether Lir ameliorates the AD-like pathology and memory deficit induced by Hhcy. Read More

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http://link.springer.com/10.1007/s12264-018-00336-7
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http://dx.doi.org/10.1007/s12264-018-00336-7DOI Listing
January 2019
10 Reads

Toll of Mental Disorders: TLR-Mediated Function of the Innate Immune System.

Neurosci Bull 2019 Jan 10. Epub 2019 Jan 10.

Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, 14214, USA.

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http://link.springer.com/10.1007/s12264-018-00335-8
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http://dx.doi.org/10.1007/s12264-018-00335-8DOI Listing
January 2019
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Chronic Intermittent Hypobaric Hypoxia Ameliorates Renal Vascular Hypertension Through Up-regulating NOS in Nucleus Tractus Solitarii.

Neurosci Bull 2019 Feb 7;35(1):79-90. Epub 2019 Jan 7.

Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.

Chronic intermittent hypobaric hypoxia (CIHH) is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension (RVH). In this study, RVH was induced by the 2-kidney-1-clip method (2K1C) in adult male Sprague-Dawley rats. The rats were then treated with hypobaric hypoxia simulating 5000 m altitude for 6 h/day for 28 days. Read More

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http://dx.doi.org/10.1007/s12264-018-00330-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357268PMC
February 2019
2 Reads

Expression and Function of Zinc-α2-Glycoprotein.

Neurosci Bull 2019 Jan 4. Epub 2019 Jan 4.

Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Zinc-α2-glycoprotein (ZAG), encoded by the AZGP1 gene, is a major histocompatibility complex I molecule and a lipid-mobilizing factor. ZAG has been demonstrated to promote lipid metabolism and glucose utilization, and to regulate insulin sensitivity. Apart from adipose tissue, skeletal muscle, liver, and kidney, ZAG also occurs in brain tissue, but its distribution in brain is debatable. Read More

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http://dx.doi.org/10.1007/s12264-018-00332-xDOI Listing
January 2019
3 Reads

Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells.

Neurosci Bull 2019 Apr 3;35(2):216-224. Epub 2019 Jan 3.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.

Diffuse intrinsic pontine glioma (DIPG) is the main cause of brain tumor-related death among children. Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Read More

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http://dx.doi.org/10.1007/s12264-018-00329-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426892PMC
April 2019
4 Reads

Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population.

Neurosci Bull 2019 Jan 3. Epub 2019 Jan 3.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.

Antipsychotic-induced weight gain (AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. Read More

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http://dx.doi.org/10.1007/s12264-018-0323-6DOI Listing
January 2019
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Brain Banking for Research into Neurodegenerative Disorders and Ageing.

Neurosci Bull 2019 Apr 2;35(2):283-288. Epub 2019 Jan 2.

Neuroscience Research Australia and the University of New South Wales, Sydney, Australia.

Advances in cellular and molecular biology underpin most current therapeutic advances in medicine. Such advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens. It is becoming increasingly evident that greater access to human brain tissue is necessary to understand both the cellular biology of these diseases and their variation. Read More

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http://link.springer.com/10.1007/s12264-018-0326-3
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http://dx.doi.org/10.1007/s12264-018-0326-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426907PMC
April 2019
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The Glutamatergic Postrhinal Cortex-Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval.

Neurosci Bull 2019 Jan 2. Epub 2019 Jan 2.

Department of Neurology, Affiliated ZhongDa Hospital, Institute of Neuropsychiatry, School of Medicine, Southeast University, Nanjing, 210009, China.

A deficit in spatial memory has been taken as an early predictor of Alzheimer's disease (AD) or mild cognitive impairment (MCI). The uncinate fasciculus (UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex (OFC) in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. Read More

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http://dx.doi.org/10.1007/s12264-018-0325-4DOI Listing
January 2019
1 Read