1,007 results match your criteria Neuroscience Bulletin [Journal]


MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells.

Neurosci Bull 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience of the Ministry of Education and National Health and Family Planning Commission, Neuroscience Research Institute, Peking University, Beijing, 100191, China.

MicroRNA-132 (miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain. Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells (NSCs) and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration (MSA) model. Read More

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http://dx.doi.org/10.1007/s12264-019-00338-zDOI Listing
February 2019

Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies.

Neurosci Bull 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Alzheimer's disease (AD) is characterized by decreased neuronal activity and atrophy, while hyperactivity of neurons seems to make them resistant to aging and neurodegeneration, a phenomenon which we have paraphrased as 'use it or lose it'. Our hypothesis proposes that (1) during their functioning, neurons are damaged; (2) accumulation of damage that is not repaired is the basis of aging; (3) the vulnerability to AD is determined by the genetic background and the balance between the amount of damage and the efficiency of repair, and (4) by stimulating the brain, repair mechanisms are stimulated and cognitive reserve is increased, resulting in a decreased rate of aging and risk for AD. Environmental stimulating factors such as bilingualism/multilingualism, education, occupation, musical experience, physical exercise, and leisure activities have been reported to reduce the risk of dementia and decrease the rate of cognitive decline, although methodological problems are present. Read More

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http://dx.doi.org/10.1007/s12264-019-00340-5DOI Listing
February 2019

Quantification of Tyrosine Hydroxylase and ErbB4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin.

Neurosci Bull 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

The locus coeruleus (LC) has been studied in major depressive disorder (MDD) and bipolar disorder (BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown pigment neuromelanin. Here, we used a multispectral method to untangle the two colors: blue immunocytochemical staining and brown neuromelanin. Read More

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http://dx.doi.org/10.1007/s12264-019-00339-yDOI Listing
January 2019
1 Read

Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice.

Neurosci Bull 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Epilepsy is a chronic and severe neurological disorder that has negative effects on the autonomous activities of patients. Functionally, Trem2 (triggering receptor expressed on myeloid cells-2) is an immunoglobulin receptor that affects neurological and psychiatric genetic diseases. Based on this rationale, we aimed to assess the potential role of Trem2 integration with the PI3K/Akt pathway in epilepsy. Read More

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http://link.springer.com/10.1007/s12264-018-0324-5
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http://dx.doi.org/10.1007/s12264-018-0324-5DOI Listing
January 2019
3 Reads

Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice.

Neurosci Bull 2019 Jan 25. Epub 2019 Jan 25.

Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of The Ministry of Education, and The Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, 200433, China.

The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas of demyelination. Thus, promoting the differentiation of OPCs is vital for the treatment of demyelinating diseases. Shikimic acid (SA) is mainly derived from star anise, and is reported to have anti-influenza, anti-oxidation, and anti-tumor effects. Read More

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http://dx.doi.org/10.1007/s12264-018-0322-7DOI Listing
January 2019

Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats.

Neurosci Bull 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurosurgery, The Second People's Hospital of Liaocheng, Linqing, 252601, China.

Gastrodin is a phenolic glycoside that has been demonstrated to provide neuroprotection in preclinical models of central nervous system disease, but its effect in subarachnoid hemorrhage (SAH) remains unclear. In this study, we showed that intraperitoneal administration of gastrodin (100 mg/kg per day) significantly attenuated the SAH-induced neurological deficit, brain edema, and increased blood-brain barrier permeability in rats. Meanwhile, gastrodin treatment significantly reduced the SAH-induced elevation of glutamate concentration in the cerebrospinal fluid and the intracellular Ca overload. Read More

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http://dx.doi.org/10.1007/s12264-018-00333-wDOI Listing
January 2019
1 Read

Autonomic Regulation of the Cardiovascular System: Diseases, Treatments, and Novel Approaches.

Neurosci Bull 2019 Feb 19;35(1):1-3. Epub 2019 Jan 19.

Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931-1200, USA.

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http://dx.doi.org/10.1007/s12264-019-00337-0DOI Listing
February 2019

Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems.

Neurosci Bull 2019 Jan 18. Epub 2019 Jan 18.

Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, 100083, China.

Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g. Read More

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http://dx.doi.org/10.1007/s12264-018-00331-yDOI Listing
January 2019
1 Read

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Neurosci Bull 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of the Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer's disease (AD), and insulin-resistance is commonly seen in patients with Hhcy. Liraglutide (Lir), a glucagon-like peptide that increases the secretion and sensitivity of insulin, has a neurotrophic or neuroprotective effect. However, it is not known whether Lir ameliorates the AD-like pathology and memory deficit induced by Hhcy. Read More

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http://link.springer.com/10.1007/s12264-018-00336-7
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http://dx.doi.org/10.1007/s12264-018-00336-7DOI Listing
January 2019
5 Reads

Toll of Mental Disorders: TLR-Mediated Function of the Innate Immune System.

Neurosci Bull 2019 Jan 10. Epub 2019 Jan 10.

Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, 14214, USA.

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http://link.springer.com/10.1007/s12264-018-00335-8
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http://dx.doi.org/10.1007/s12264-018-00335-8DOI Listing
January 2019
6 Reads

Chronic Intermittent Hypobaric Hypoxia Ameliorates Renal Vascular Hypertension Through Up-regulating NOS in Nucleus Tractus Solitarii.

Neurosci Bull 2019 Feb 7;35(1):79-90. Epub 2019 Jan 7.

Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.

Chronic intermittent hypobaric hypoxia (CIHH) is known to have an anti-hypertensive effect, which might be related to modulation of the baroreflex in rats with renal vascular hypertension (RVH). In this study, RVH was induced by the 2-kidney-1-clip method (2K1C) in adult male Sprague-Dawley rats. The rats were then treated with hypobaric hypoxia simulating 5000 m altitude for 6 h/day for 28 days. Read More

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http://dx.doi.org/10.1007/s12264-018-00330-zDOI Listing
February 2019
1 Read

Expression and Function of Zinc-α2-Glycoprotein.

Neurosci Bull 2019 Jan 4. Epub 2019 Jan 4.

Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Zinc-α2-glycoprotein (ZAG), encoded by the AZGP1 gene, is a major histocompatibility complex I molecule and a lipid-mobilizing factor. ZAG has been demonstrated to promote lipid metabolism and glucose utilization, and to regulate insulin sensitivity. Apart from adipose tissue, skeletal muscle, liver, and kidney, ZAG also occurs in brain tissue, but its distribution in brain is debatable. Read More

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http://dx.doi.org/10.1007/s12264-018-00332-xDOI Listing
January 2019
2 Reads

Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells.

Neurosci Bull 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.

Diffuse intrinsic pontine glioma (DIPG) is the main cause of brain tumor-related death among children. Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Read More

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http://dx.doi.org/10.1007/s12264-018-00329-6DOI Listing
January 2019
2 Reads

Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population.

Neurosci Bull 2019 Jan 3. Epub 2019 Jan 3.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.

Antipsychotic-induced weight gain (AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. Read More

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http://dx.doi.org/10.1007/s12264-018-0323-6DOI Listing
January 2019
1 Read

Brain Banking for Research into Neurodegenerative Disorders and Ageing.

Neurosci Bull 2019 Jan 2. Epub 2019 Jan 2.

Neuroscience Research Australia and the University of New South Wales, Sydney, Australia.

Advances in cellular and molecular biology underpin most current therapeutic advances in medicine. Such advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens. It is becoming increasingly evident that greater access to human brain tissue is necessary to understand both the cellular biology of these diseases and their variation. Read More

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http://link.springer.com/10.1007/s12264-018-0326-3
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http://dx.doi.org/10.1007/s12264-018-0326-3DOI Listing
January 2019
1 Read

The Glutamatergic Postrhinal Cortex-Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval.

Neurosci Bull 2019 Jan 2. Epub 2019 Jan 2.

Department of Neurology, Affiliated ZhongDa Hospital, Institute of Neuropsychiatry, School of Medicine, Southeast University, Nanjing, 210009, China.

A deficit in spatial memory has been taken as an early predictor of Alzheimer's disease (AD) or mild cognitive impairment (MCI). The uncinate fasciculus (UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex (OFC) in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. Read More

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http://dx.doi.org/10.1007/s12264-018-0325-4DOI Listing
January 2019

Human Brain Slice Culture: A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds.

Neurosci Bull 2019 Jan 2. Epub 2019 Jan 2.

Department of Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, 1105BA, The Netherlands.

Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed. In vivo studies of animal models and in vitro studies of cell lines/primary cell cultures may provide useful tools to study certain aspects of brain disorders. However, discrepancies among these studies or unsuccessful translation from animal/cell studies to human/clinical studies often occur, because these models generally represent only some symptoms of a neuropsychiatric disorder rather than the complete disorder. Read More

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http://dx.doi.org/10.1007/s12264-018-0328-1DOI Listing
January 2019

Brains for Dementia Research: The Importance of Cohorts in Brain Banking.

Neurosci Bull 2019 Jan 2. Epub 2019 Jan 2.

Wolfson Centre for Age-Related Diseases, King's College London, London, SE1 1UL, UK.

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http://dx.doi.org/10.1007/s12264-018-0327-2DOI Listing
January 2019

NMDA Receptor Antagonist MK801 Protects Against 1-Bromopropane-Induced Cognitive Dysfunction.

Neurosci Bull 2018 Dec 19. Epub 2018 Dec 19.

School of Public Health, Shandong University, Jinan, 250012, China.

Occupational exposure to 1-bromopropane (1-BP) induces learning and memory deficits. However, no therapeutic strategies are currently available. Accumulating evidence has suggested that N-methyl-D-aspartate receptors (NMDARs) and neuroinflammation are involved in the cognitive impairments in neurodegenerative diseases. Read More

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http://link.springer.com/10.1007/s12264-018-0321-8
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http://dx.doi.org/10.1007/s12264-018-0321-8DOI Listing
December 2018
9 Reads

Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury.

Neurosci Bull 2018 Dec 17. Epub 2018 Dec 17.

Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.

In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI). Currently, however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation (SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Read More

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http://dx.doi.org/10.1007/s12264-018-0320-9DOI Listing
December 2018
8 Reads

Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity.

Neurosci Bull 2019 Feb 17;35(1):4-14. Epub 2018 Dec 17.

Laboratory for Translational Pain Medicine, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.

The pathophysiology of visceral pain in patients with irritable bowel syndrome remains largely unknown. Our previous study showed that neonatal maternal deprivation (NMD) does not induce visceral hypersensitivity at the age of 6 weeks in rats. The aim of this study was to determine whether NMD followed by adult stress at the age of 6 weeks induces visceral pain in rats and to investigate the roles of adrenergic signaling in visceral pain. Read More

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http://dx.doi.org/10.1007/s12264-018-0318-3DOI Listing
February 2019
1 Read

Next-Generation Tools to Study Autonomic Regulation In Vivo.

Neurosci Bull 2019 Feb 17;35(1):113-123. Epub 2018 Dec 17.

Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.

The recent development of tools to decipher the intricacies of neural networks has improved our understanding of brain function. Optogenetics allows one to assess the direct outcome of activating a genetically-distinct population of neurons. Neurons are tagged with light-sensitive channels followed by photo-activation with an appropriate wavelength of light to functionally activate or silence them, resulting in quantifiable changes in the periphery. Read More

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http://dx.doi.org/10.1007/s12264-018-0319-2DOI Listing
February 2019

Neuroprotective Autophagic Flux Induced by Hyperbaric Oxygen Preconditioning is Mediated by Cystatin C.

Neurosci Bull 2018 Dec 5. Epub 2018 Dec 5.

Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.

We have previously reported that Cystatin C (CysC) is a pivotal mediator in the neuroprotection induced by hyperbaric oxygen (HBO) preconditioning; however, the underlying mechanism and how CysC changes after stroke are not clear. In the present study, we demonstrated that CysC expression was elevated as early as 3 h after reperfusion, and this was further enhanced by HBO preconditioning. Concurrently, LC3-II and Beclin-1, two positive-markers for autophagy induction, exhibited increases similar to CysC, while knockdown of CysC blocked these elevations. Read More

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http://link.springer.com/10.1007/s12264-018-0313-8
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http://dx.doi.org/10.1007/s12264-018-0313-8DOI Listing
December 2018
11 Reads

Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension.

Neurosci Bull 2019 Feb 1;35(1):124-132. Epub 2018 Dec 1.

Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, MO, 65212, USA.

The hypothalamic paraventricular nucleus (PVN) is a crucial region involved in maintaining homeostasis through the regulation of cardiovascular, neuroendocrine, and other functions. The PVN provides a dominant source of excitatory drive to the sympathetic outflow through innervation of the brainstem and spinal cord in hypertension. We discuss current findings on the role of the PVN in the regulation of sympathetic output in both normotensive and hypertensive conditions. Read More

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http://link.springer.com/10.1007/s12264-018-0316-5
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http://dx.doi.org/10.1007/s12264-018-0316-5DOI Listing
February 2019
15 Reads

Aberrant Resting-State Functional Connectivity in the Default Mode Network in Pediatric Bipolar Disorder Patients with and without Psychotic Symptoms.

Neurosci Bull 2018 Dec 4. Epub 2018 Dec 4.

Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.

Mood disorders/psychosis have been associated with dysfunctions in the default mode network (DMN). However, the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder (PBD) remain unclear. The aim of this study was to investigate the possible mechanisms of PBD through brain imaging and explore the influence of psychotic symptoms on functional alterations in PBD patients. Read More

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http://dx.doi.org/10.1007/s12264-018-0315-6DOI Listing
December 2018
1 Read

The Stanley Neuropathology Consortium Integrative Database (SNCID) for Psychiatric Disorders.

Neurosci Bull 2018 Nov 27. Epub 2018 Nov 27.

Stanley Brain Research Laboratory, Stanley Medical Research Institute, 9800 Medical Center Drive, Rockville, MD, 20850, USA.

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http://dx.doi.org/10.1007/s12264-018-0314-7DOI Listing
November 2018

Altered Local Field Potential Relationship Between the Parafascicular Thalamic Nucleus and Dorsal Striatum in Hemiparkinsonian Rats.

Neurosci Bull 2018 Nov 27. Epub 2018 Nov 27.

Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Jinan, 250014, China.

The thalamostriatal pathway is implicated in Parkinson's disease (PD); however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex (CM/Pf, or the Pf in rodents) and the dorsal striatum (DS) remain unclear. Therefore, we simultaneously recorded local field potentials (LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band (12 Hz-35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta (0. Read More

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http://dx.doi.org/10.1007/s12264-018-0312-9DOI Listing
November 2018
1 Read

Baroreflex Control of Heart Rate in Mice Overexpressing Human SOD1: Functional Changes in Central and Vagal Efferent Components.

Neurosci Bull 2019 Feb 20;35(1):91-97. Epub 2018 Nov 20.

Division of Neuroscience and Division of Metabolic and Cardiovascular Sciences, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32816, USA.

Excessive reactive oxygen species (ROS) (such as the superoxide radical) are commonly associated with cardiac autonomic dysfunctions. Though superoxide dismutase 1 (SOD1) overexpression may protect against ROS damage to the autonomic nervous system, superoxide radical reduction may change normal physiological functions. Previously, we demonstrated that human SOD1 (hSOD1) overexpression does not change baroreflex bradycardia and tachycardia but rather increases aortic depressor nerve activity in response to arterial pressure changes in C57B6SJL-Tg (SOD1)2 Gur/J mice. Read More

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http://dx.doi.org/10.1007/s12264-018-0302-yDOI Listing
February 2019
5 Reads

Decreased β-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes.

Neurosci Bull 2019 Feb 15;35(1):25-33. Epub 2018 Nov 15.

Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

The influence of β-cell function on cardiovascular autonomic neuropathy (CAN), an important diabetes-related complication, is still unclear. In this study, we aimed to investigate the association between residual β-cell function and CAN in patients newly diagnosed with type 2 diabetes. We enrolled 90 newly-diagnosed type 2 diabetic patients and 37 participants with normal glucose tolerance as controls. Read More

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http://link.springer.com/10.1007/s12264-018-0304-9
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February 2019
7 Reads

Chronic Intracerebroventricular Infusion of Metformin Inhibits Salt-Sensitive Hypertension via Attenuation of Oxidative Stress and Neurohormonal Excitation in Rat Paraventricular Nucleus.

Neurosci Bull 2019 Feb 14;35(1):57-66. Epub 2018 Nov 14.

Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Ministry of Education Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, 710061, China.

Metformin (MET), an antidiabetic agent, also has antioxidative effects in metabolic-related hypertension. This study was designed to determine whether MET has anti-hypertensive effects in salt-sensitive hypertensive rats by inhibiting oxidative stress in the hypothalamic paraventricular nucleus (PVN). Salt-sensitive rats received a high-salt (HS) diet to induce hypertension, or a normal-salt (NS) diet as control. Read More

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http://dx.doi.org/10.1007/s12264-018-0308-5DOI Listing
February 2019
1 Read

Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy.

Neurosci Bull 2018 Nov 13. Epub 2018 Nov 13.

Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044, China.

The present study was aimed to evaluate resting-state functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls. Resting-state fMRI was performed in 26 adult narcolepsy patients and 30 matched healthy controls. MRI data were first analyzed by group independent component analysis, then a graph theoretical method was applied to evaluate the topological properties in the whole brain. Read More

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http://link.springer.com/10.1007/s12264-018-0307-6
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http://dx.doi.org/10.1007/s12264-018-0307-6DOI Listing
November 2018
10 Reads

The Mitochondrion: A Potential Therapeutic Target for Alzheimer's Disease.

Neurosci Bull 2018 Dec 12;34(6):1127-1130. Epub 2018 Nov 12.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.

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http://dx.doi.org/10.1007/s12264-018-0310-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246833PMC
December 2018

A Critical Time-Window for the Selective Induction of Hippocampal Memory Consolidation by a Brief Episode of Slow-Wave Sleep.

Neurosci Bull 2018 Dec 9;34(6):1091-1099. Epub 2018 Nov 9.

Department of Neurobiology, Institute of Neuroscience, National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Although extensively studied, the exact role of sleep in learning and memory is still not very clear. Sleep deprivation has been most frequently used to explore the effects of sleep on learning and memory, but the results from such studies are inevitably complicated by concurrent stress and distress. Furthermore, it is not clear whether there is a strict time-window between sleep and memory consolidation. Read More

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http://link.springer.com/10.1007/s12264-018-0303-x
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http://dx.doi.org/10.1007/s12264-018-0303-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246845PMC
December 2018
12 Reads

A Shared Neural Node for Multiple Innate Behaviors in Drosophila.

Authors:
Margaret S Ho

Neurosci Bull 2018 Dec 9;34(6):1103-1104. Epub 2018 Nov 9.

School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.

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http://link.springer.com/10.1007/s12264-018-0311-x
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http://dx.doi.org/10.1007/s12264-018-0311-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246851PMC
December 2018
1 Read

Standardized Operational Protocol for Human Brain Banking in China.

Neurosci Bull 2018 Nov 8. Epub 2018 Nov 8.

Department of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 10005, China.

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http://link.springer.com/10.1007/s12264-018-0306-7
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http://dx.doi.org/10.1007/s12264-018-0306-7DOI Listing
November 2018
17 Reads

Comparison of Reference Genes for Transcriptional Studies in Postmortem Human Brain Tissue Under Different Conditions.

Neurosci Bull 2018 Nov 7. Epub 2018 Nov 7.

Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China.

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http://link.springer.com/10.1007/s12264-018-0309-4
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http://dx.doi.org/10.1007/s12264-018-0309-4DOI Listing
November 2018
6 Reads

Legal and Ethical Issues in Brain Banking.

Neurosci Bull 2018 Nov 3. Epub 2018 Nov 3.

Netherlands Brain Bank, Netherlands Institute for Neuroscience, Netherlands Royal Academy of Arts and Sciences, Amsterdam, Netherlands.

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http://dx.doi.org/10.1007/s12264-018-0305-8DOI Listing
November 2018

Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy.

Neurosci Bull 2018 Oct 31. Epub 2018 Oct 31.

China Brain Bank and Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Primary age-related tauopathy (PART) is characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology. In the present study, we analyzed the distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) in the brains of patients with PART. Immunohistochemistry and immunofluorescence double-labeling in multiple brain regions was performed on brain tissues from PART, Alzheimer's disease (AD), and aging control cases. Read More

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http://link.springer.com/10.1007/s12264-018-0300-0
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http://dx.doi.org/10.1007/s12264-018-0300-0DOI Listing
October 2018
12 Reads

Pericyte Plasticity in the Brain.

Neurosci Bull 2018 Oct 26. Epub 2018 Oct 26.

Departamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.

Cerebral pericytes are perivascular cells that stabilize blood vessels. Little is known about the plasticity of pericytes in the adult brain in vivo. Recently, using state-of-the-art technologies, including two-photon microscopy in combination with sophisticated Cre/loxP in vivo tracing techniques, a novel role of pericytes was revealed in vascular remodeling in the adult brain. Read More

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http://link.springer.com/10.1007/s12264-018-0296-5
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http://dx.doi.org/10.1007/s12264-018-0296-5DOI Listing
October 2018
9 Reads

Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension.

Neurosci Bull 2019 Feb 16;35(1):47-56. Epub 2018 Oct 16.

Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, 710061, China.

Angiotensin (Ang)-(1-7) is an important biologically-active peptide of the renin-angiotensin system. This study was designed to determine whether inhibition of Ang-(1-7) in the hypothalamic paraventricular nucleus (PVN) attenuates sympathetic activity and elevates blood pressure by modulating pro-inflammatory cytokines (PICs) and oxidative stress in the PVN in salt-induced hypertension. Rats were fed either a high-salt (8% NaCl) or a normal salt diet (0. Read More

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http://link.springer.com/10.1007/s12264-018-0297-4
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http://dx.doi.org/10.1007/s12264-018-0297-4DOI Listing
February 2019
2 Reads

Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats.

Neurosci Bull 2019 Feb 15;35(1):67-78. Epub 2018 Oct 15.

Department of Physiology, Second Military Medical University, Shanghai, 200433, China.

The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. Read More

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http://dx.doi.org/10.1007/s12264-018-0298-3DOI Listing
February 2019
3 Reads

Orthostatic Intolerance and Coagulation Abnormalities: An Update.

Neurosci Bull 2019 Feb 13;35(1):171-177. Epub 2018 Oct 13.

Department of Pediatrics, Peking University First Hospital, Beijing, 100034, China.

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http://dx.doi.org/10.1007/s12264-018-0295-6DOI Listing
February 2019

Autonomic Disturbances in Acute Cerebrovascular Disease.

Neurosci Bull 2019 Feb 11;35(1):133-144. Epub 2018 Oct 11.

Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA.

Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous system. We review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia. Read More

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http://dx.doi.org/10.1007/s12264-018-0299-2DOI Listing
February 2019

The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia.

Neurosci Bull 2018 Dec 10;34(6):1131-1136. Epub 2018 Oct 10.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

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http://link.springer.com/10.1007/s12264-018-0294-7
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http://dx.doi.org/10.1007/s12264-018-0294-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246843PMC
December 2018
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Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.

Neurosci Bull 2019 Feb 1;35(1):34-46. Epub 2018 Oct 1.

Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, 211166, China.

Intermedin/adrenomedullin-2 (IMD/AM2), a member of the calcitonin gene-related peptide/AM family, plays an important role in protecting the cardiovascular system. However, its role in the enhanced sympathoexcitation in obesity-related hypertension is unknown. In this study, we investigated the effects of IMD in the paraventricular nucleus (PVN) of the hypothalamus on sympathetic nerve activity (SNA), and lipopolysaccharide (LPS)-induced sympathetic activation in obesity-related hypertensive (OH) rats induced by a high-fat diet for 12 weeks. Read More

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http://link.springer.com/10.1007/s12264-018-0292-9
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http://dx.doi.org/10.1007/s12264-018-0292-9DOI Listing
February 2019
11 Reads

Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina.

Neurosci Bull 2018 Sep 28. Epub 2018 Sep 28.

Department of Pathophysiology, School of Basic Medicine and Collaborative Innovation Center for Brain Science, Key Laboratory for Neurological Disorders of the Ministry of Education of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer's disease (AD). Visual dysfunction is commonly found and is positively correlated with the severity of cognitive defects in AD patients. Our previous study demonstrated that Hhcy induces memory deficits with AD-like tau and amyloid-β (Aβ) pathologies in the hippocampus, and supplementation with folate and vitamin B12 (FB) prevents the Hhcy-induced AD-like pathologies in the hippocampus. Read More

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http://dx.doi.org/10.1007/s12264-018-0293-8DOI Listing
September 2018
11 Reads

Illuminating the Activated Brain: Emerging Activity-Dependent Tools to Capture and Control Functional Neural Circuits.

Neurosci Bull 2018 Sep 26. Epub 2018 Sep 26.

Center for Neuroscience, and Department of Psychiatry of First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Immediate-early genes (IEGs) have long been used to visualize neural activations induced by sensory and behavioral stimuli. Recent advances in imaging techniques have made it possible to use endogenous IEG signals to visualize and discriminate neural ensembles activated by multiple stimuli, and to map whole-brain-scale neural activation at single-neuron resolution. In addition, a collection of IEG-dependent molecular tools has been developed that can be used to complement the labeling of endogenous IEG genes and, especially, to manipulate activated neural ensembles in order to reveal the circuits and mechanisms underlying different behaviors. Read More

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http://dx.doi.org/10.1007/s12264-018-0291-xDOI Listing
September 2018
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Parkinson's Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain.

Neurosci Bull 2018 Sep 17. Epub 2018 Sep 17.

Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Department of Neurology, Affiliated Hospital of Taishan Medical College, Taian, 271016, China.

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http://dx.doi.org/10.1007/s12264-018-0289-4DOI Listing
September 2018