980 results match your criteria Neurosarcoidosis


For Whom the Bell's Toll: Recurrent Facial Nerve Paralysis, A Retrospective Study and Systematic Review of the Literature.

Otol Neurotol 2019 Apr;40(4):517-528

Department of Otorhinolaryngology.

Purpose: To examine the etiology, clinical course, and management of recurrent peripheral facial nerve paralysis.

Methods: Retrospective review at a single tertiary academic center and systematic review of the literature. Clinical presentation, laboratory and imaging findings, treatment and outcome for all cases of recurrent ipsilateral, recurrent contralateral, and bilateral simultaneous cases of facial paralysis are reviewed. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002167DOI Listing

Management of neurosarcoidosis: a clinical challenge.

Curr Opin Neurol 2019 Mar 6. Epub 2019 Mar 6.

Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.

Purpose Of Review: Sarcoidosis is a complex disease with many faces, and the clinical manifestation and course of neurosarcoidosis are particularly variable. Although neurosarcoidosis occurs in up to 10% of sarcoidosis patients, it can lead to significant morbidity and some mortality.

Recent Findings: Three criteria are usually required for a diagnosis of (neuro)sarcoidosis: clinical and radiologic manifestations, noncaseating granulomas, and no evidence of alternative disease. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000684DOI Listing

Granulomatous CNS inflammation associated with seminoma.

J Neurol 2019 Mar 11. Epub 2019 Mar 11.

Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, UK.

Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment. Read More

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http://dx.doi.org/10.1007/s00415-019-09270-8DOI Listing
March 2019
1 Read

An Ominous Facial Droop.

Am J Med 2019 Mar 7. Epub 2019 Mar 7.

Department of Medicine, McMaster University, Health Sciences Centre, 4V33, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.amjmed.2019.02.017DOI Listing

For Whom the Bell's Toll: Recurrent Facial Nerve Paralysis, A Retrospective Study and Systematic Review of the Literature.

Otol Neurotol 2019 Feb 27. Epub 2019 Feb 27.

Department of Otorhinolaryngology.

Purpose: To examine the etiology, clinical course, and management of recurrent peripheral facial nerve paralysis.

Methods: Retrospective review at a single tertiary academic center and systematic review of the literature. Clinical presentation, laboratory and imaging findings, treatment and outcome for all cases of recurrent ipsilateral, recurrent contralateral, and bilateral simultaneous cases of facial paralysis are reviewed. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002167DOI Listing
February 2019
1 Read

Skull Base Manifestations of Erdheim-Chester Disease: A Case Series and Systematic Review.

Neurosurgery 2019 Mar 4. Epub 2019 Mar 4.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis. Up to 50% of patients develop central nervous system involvement, and a subset of these patients can present with isolated tumor-like masses.

Objective: To describe the skull base manifestations of ECD with an emphasis on aspects most pertinent to surgeons who may be referred such patients for primary evaluation. Read More

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http://dx.doi.org/10.1093/neuros/nyz027DOI Listing
March 2019
2 Reads

Magnetic resonance texture analysis utility in differentiating intraparenchymal neurosarcoidosis from primary central nervous system lymphoma: a preliminary analysis.

Neuroradiol J 2019 Feb 21:1971400919830173. Epub 2019 Feb 21.

4 Institute of Nuclear Medicine, University College London, Institute of Nuclear Medicine, UK.

Purpose: Neurosarcoidosis and primary central nervous system lymphomas, although distinct disease entities, can both have overlapping neuroimaging findings. The purpose of our preliminary study was to assess if magnetic resonance texture analysis can differentiate parenchymal mass-like neurosarcoidosis granulomas from primary central nervous system lymphomas.

Methods: A total of nine patients was evaluated, four with parenchymal neurosarcoidosis granulomas and five with primary central nervous system lymphomas. Read More

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http://journals.sagepub.com/doi/10.1177/1971400919830173
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http://dx.doi.org/10.1177/1971400919830173DOI Listing
February 2019
4 Reads

Cold at the Core: Osborn Waves in Neurosarcoidosis-Induced Central Hypothermia.

Case Rep Cardiol 2019 15;2019:5845839. Epub 2019 Jan 15.

Department of Medicine, Division of Advanced Heart Failure and Transplant Cardiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Osborn waves, or J waves, initially described by John Osborn in 1953 in hypothermic dog experiments, are highly sensitive and specific for hypothermia. Initially thought to be secondary to a hypothermia-induced "injury current," they have more recently been attributed to a voltage differential between epicardial and endocardial potassium (I) currents. While the exact conditions required to induce such waves have been debated, numerous clinical scenarios of environmental and iatrogenic hypothermia have been described. Read More

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http://dx.doi.org/10.1155/2019/5845839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350583PMC
January 2019
4 Reads

Infliximab biosimilar for treating neurosarcoidosis: tolerance and efficacy in a retrospective study including switch from the originator and initiation of treatment.

J Neurol 2019 Feb 9. Epub 2019 Feb 9.

Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'hôpital, 75651, Paris Cedex 13, France.

Objectives: Infliximab is increasingly used to treat neurosarcoidosis. We aimed to determine the efficacy and tolerance of an infliximab biosimilar for treating neurosarcoidosis.

Methods: We conducted a retrospective single-center study to describe the efficacy, safety and immunogenicity of an infliximab biosimilar in neurosarcoidosis patients. Read More

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http://dx.doi.org/10.1007/s00415-019-09234-yDOI Listing
February 2019
10 Reads

Multiple cerebral infarcts: a rare complication of neurosarcoidosis.

Pract Neurol 2019 Jan 30. Epub 2019 Jan 30.

Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

A 52-year-old man experienced a relapse of neurosarcoidosis, characterised by obstructive hydrocephalus and multiple posterior circulation infarcts. He was taking methotrexate, but his prednisolone was being weaned because of adverse effects. Stroke is rare in neurosarcoidosis and typically relates to granulomatous inflammation with a predilection for the perforator arteries. Read More

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http://dx.doi.org/10.1136/practneurol-2018-002133DOI Listing
January 2019
2 Reads

Neurosarcoidosis as a Cause of Longitudinally Extensive Myelitis: Neuroimaging Clues for Diagnosis.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):100-101

Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

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http://dx.doi.org/10.4103/aian.AIAN_162_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327707PMC
January 2019

Engorged Medullary Veins in Neurosarcoidosis: A Reflection of Underlying Phlebitis?

AJNR Am J Neuroradiol 2019 Mar 24;40(3):E14-E15. Epub 2019 Jan 24.

Division of Neuroradiology, Michigan Radiology University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.3174/ajnr.A5951DOI Listing

Disseminated Histoplasmosis with Miliary Histoplasmosis, Neurohistoplasmosis, and Bacteremia in Probable Neurosarcoidosis.

Authors:
Peter V Bui

Case Rep Med 2018 11;2018:3162403. Epub 2018 Dec 11.

Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.

Introduction: Neurosarcoidosis, either isolated or as part of systemic sarcoidosis, is an uncommon entity and has diagnostic uncertainty. Treatment for neurosarcoidosis can increase the risk of infections, including fungal infections such as disseminated histoplasmosis. Neurosarcoidosis may further predispose patients to infections of the central nervous system. Read More

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http://dx.doi.org/10.1155/2018/3162403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311783PMC
December 2018
4 Reads

[Neurosarcoidosis remains a diagnostic chameleon : First manifestation of neurosarcoidosis as longitudinal transverse myelitis].

Nervenarzt 2019 Jan 7. Epub 2019 Jan 7.

Klinik für Innere Medizin, Spital Linth, Gasterstraße 25, 8730, Uznach, Schweiz.

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http://dx.doi.org/10.1007/s00115-018-0652-8DOI Listing
January 2019
2 Reads

A confusing manifestation: a case report of neurosarcoidosis presenting with confusion.

J Community Hosp Intern Med Perspect 2018 11;8(6):363-367. Epub 2018 Dec 11.

HCA-West Florida Division, Tampa, FL, USA.

Sarcoidosis is an inflammatory granulomatous multisystem disease with an unknown etiology. Neurosarcoidosis is a cryptogenic neuroinflammatory manifestation of sarcoidosis. We describe a case of neurosarcoidosis with initial presentation as confusion. Read More

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http://dx.doi.org/10.1080/20009666.2018.1536239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292345PMC
December 2018

Sarcoidosis of the medulla oblongata causing intractable hiccoughs and numbness of extremities: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13667

Rationale: Sarcoidosis is a multisystem disorder characterized by noncaseating granulomas. The nervous system is involved in 5 to 16% of the patients. However, neurosarcoidosis in the medulla oblongata presenting as hiccough is remarkably rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000013667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320214PMC
December 2018
3 Reads

Sarkoidosis and its Eye Ocular Manifestation (an Analysis of Six Case Report).

Cesk Slov Oftalmol 2018 ;73(5-6):189-197

Aim: To introduce the range of eye changes in sarcoidosis in the individual casuistics.

Materials: At the Ophthalmic Clinic of Teaching Hospital Královské Vinohrady in Prague were examined and treated six patients with ocular forms of sarcoidosis in the years from 1998 to 2015. Three patients were unilateral lesions of the lacrimal gland without systemic symptoms. Read More

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January 2018

Cochlear Implantation of a Patient with Definitive Neurosarcoidosis.

OTO Open 2017 Oct-Dec;1(4):2473974X17742633. Epub 2017 Nov 15.

Department of Otolaryngology, New York University Langone Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1177/2473974X17742633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239151PMC
November 2017

Anosmia as the initial presentation of neurosarcoidosis.

Neurology 2018 Nov;91(22):1020-1021

From the Department of Neurology, University of Washington, Seattle.

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http://dx.doi.org/10.1212/WNL.0000000000006582DOI Listing
November 2018

Comparison of costs and outcomes of patients presenting with a rare brainstem syndrome.

eNeurologicalSci 2018 Dec 2;13:21-23. Epub 2018 Nov 2.

Dartmouth-Hitchcock Medical Center, Department of Neurology, 1 Medical Center Drive, NH 03756, Lebanon.

In this case report we compare two patients presenting with similar symptoms of a brainstem syndrome including ataxia, dysarthria, and diplopia. Their MRIs showed hyperintense FLAIR signal changes with patchy areas of contrast enhancement within the brainstem particularly the pons and cerebellum. The broad differential diagnosis of this brainstem pathology included rhomboencephalitis, neurosarcoidosis, lymphoma, vasculitis, infection, and paraneoplastic or autoimmune process. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056502183003
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http://dx.doi.org/10.1016/j.ensci.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226594PMC
December 2018
11 Reads

A case of fatal invasive aspergillosis in a patient with neurosarcoidosis treated with infliximab.

Int J Neurosci 2018 Nov 15:1-4. Epub 2018 Nov 15.

a Department of Neurology and Rehabilitation Medicine , University of Cincinnati , Cincinnati , OH , USA.

Introduction: CNS involvement in sarcoidosis is seen in 5-10% of cases. Long term treatment involves steroids and other immunomodulatory agents, including infliximab. Chronic immunosuppression can result in increased patient susceptibility to opportunistic infections. Read More

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http://dx.doi.org/10.1080/00207454.2018.1544130DOI Listing
November 2018
7 Reads
1.530 Impact Factor

Neuroimaging Findings in Intracranial Sarcoid Phlebitis: A Case Report.

J Stroke Cerebrovasc Dis 2019 Feb 2;28(2):369-370. Epub 2018 Nov 2.

Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Electronic address:

Introduction: Venous phlebitis in Neurosarcoidosis (NS) is rare but is often associated with intracranial hemorrhage (ICH). Imaging findings in such cases have been recently described on susceptibility weighted imaging (SWI).

Case Presentation And Outcome: We report a patient who presented with ICH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183058
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.003DOI Listing
February 2019
14 Reads

Successful therapy with rituximab in three patients with probable neurosarcoidosis.

Ther Adv Neurol Disord 2018 26;11:1756286418805732. Epub 2018 Oct 26.

Department of Neurology at Katholische Kliniken Ruhrhalbinsel Essen, Essen, Germany.

Background: Neurosarcoidosis occurs in about 5-15% of patients with sarcoidosis. Therapy with corticosteroids is generally accepted as the first-line medication, followed by various immunomodulating and cytotoxic agents or combined therapy. However, some patients show an unsatisfactory outcome or have adverse events and require novel treatment strategies. Read More

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http://dx.doi.org/10.1177/1756286418805732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204624PMC
October 2018
3 Reads

Diagnostic Approach to Chronic Meningitis.

Neurol Clin 2018 Nov 20;36(4):831-849. Epub 2018 Sep 20.

Department of Neurology, Geisinger Commonwealth School of Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, USA.

Chronic meningitis is defined as cerebrospinal fluid pleocytosis that persists for at least 4 weeks without spontaneous resolution. The differential diagnosis of chronic meningitis is broad, encompassing 4 main categories, including infectious, autoimmune, neoplastic, and idiopathic. Up to one-third of cases have no discernible cause, making chronic meningitis a diagnostic dilemma for many clinicians. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338619183123
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http://dx.doi.org/10.1016/j.ncl.2018.06.004DOI Listing
November 2018
20 Reads

Neurosarcoidosis Presenting Initially as Idiopathic Vocal Cord Paralysis.

Ann Otol Rhinol Laryngol 2019 Feb 26;128(2):157-161. Epub 2018 Oct 26.

2 Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction:: The presentation, course, and management of a rare laryngeal manifestation of neurosarcoidosis due to central nervous system (as opposed to peripheral nervous system) injury are described.

Methods:: The authors present 3 cases of vocal cord paralysis as the initial symptom of isolated neurosarcoidosis at a tertiary care laryngology clinic.

Results:: Laryngoscopy diagnosed unilateral vocal cord paralysis. Read More

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http://dx.doi.org/10.1177/0003489418808814DOI Listing
February 2019
11 Reads

Sarcoid uveitis in a patient with multiple neurological lesions: a case report and review of the literature.

J Med Case Rep 2018 Oct 23;12(1):307. Epub 2018 Oct 23.

Department of Ophthalmology and Visual science, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.

Background: Neurosarcoidosis is a rare complication, and cranial neuropathy is the most frequent manifestation of this disease. However, few cohesive reports have discussed multiple cranial neuropathies in Japanese patients with sarcoidosis. The present report discusses the case of a patient with sarcoid uveitis and multiple neurological findings. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1842-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198507PMC
October 2018
14 Reads

FDG-PET abnormalities leading to the diagnosis of an unusual case of probable neurosarcoidosis.

Neurol Neuroimmunol Neuroinflamm 2018 Nov 26;5(6):e506. Epub 2018 Sep 26.

Department of Neurology (Y.W., A.W.), University of Washington; Division of Rheumatology (J.A.), Department of Internal Medicine, University of Washington; and Department of Pathology (P.J.C.), University of Washington, Seattle.

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http://dx.doi.org/10.1212/NXI.0000000000000506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192693PMC
November 2018

[Cerebral neurosarcoidosis].

Pan Afr Med J 2018 28;30:67. Epub 2018 May 28.

Service de Neurologie, Hôpital Militaire Moulay Ismail, Meknès, Maroc.

We report the case of a 37-year old patient with right optic neuropathy. Magnetic resonance imaging (MRI) showed T2 hypersignal in the midline, enhanced after gadolinium injection (figure 1). Cerebrospinal fluid (CSF) analysis revealed lymphocytic meningitis with 64 white blood cells associated with hyperproteinorachy. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.67.15632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191271PMC
October 2018
4 Reads

Orbitocerebral Mucormycosis in a Patient With Central Nervous System Lymphoma.

Ophthalmic Plast Reconstr Surg 2018 Nov/Dec;34(6):e197-e201

Ruiz Department of Ophthalmology and Visual Science.

A 61-year-old man with well-controlled diabetes mellitus type 2, cirrhosis from hepatitis C, alcohol abuse, and portal hypertension presented with painful vision loss and left orbital swelling. Imaging showed diffuse orbital, perineural, and pachymeningeal inflammation. He was initially diagnosed with neurosarcoidosis. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231966PMC
November 2019
14 Reads

Imaging findings in spinal sarcoidosis: a report of 18 cases and review of the current literature.

Neuroradiol J 2019 Feb 12;32(1):17-28. Epub 2018 Oct 12.

Neuroradiology Department, University of Iowa Hospitals and Clinics, USA.

Purpose: Spinal sarcoidosis, referring to involvement of the spine in sarcoidosis, is relatively rare and may mimic other neurological disease affecting the spine. The authors present a clinic radiological review of 18 spinal sarcoidosis patients who presented to a tertiary hospital, with emphasis on initial imaging and radiological response to treatment.

Materials And Methods: We retrospectively reviewed our departmental imaging archives over a 15-year period and found 49 cases of neurosarcoidosis out of which 18 patients had spinal magnetic resonance imaging. Read More

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http://journals.sagepub.com/doi/10.1177/1971400918806634
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http://dx.doi.org/10.1177/1971400918806634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327364PMC
February 2019
9 Reads

Neurosarcoidosis As a Rare Differential Diagnosis for Single Or Multiple Lesions of the Nervous System.

Br J Neurosurg 2018 Oct 8:1-5. Epub 2018 Oct 8.

d Department of Otorhinolaryngology, Head and Neck Surgery , University of Bonn , Bonn , Germany.

Objective: Sarcoidosis is a multisystemic granulomatous disease of unknown cause which affects the lung or bilateral hilar lymphadenopathy in over 90% of the cases. Neurosarcoidosis (NS) is rare and accounts for approximately 5 - 15% of the cases. Involvement of all parts of the central and peripheral nervous system is possible with various clinical symptoms, e. Read More

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https://www.tandfonline.com/doi/full/10.1080/02688697.2018.1
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http://dx.doi.org/10.1080/02688697.2018.1506094DOI Listing
October 2018
4 Reads

Engorgement of Deep Medullary Veins in Neurosarcoidosis: A Common-Yet-Underrecognized Cerebrovascular Finding on SWI.

AJNR Am J Neuroradiol 2018 Nov 20;39(11):2045-2050. Epub 2018 Sep 20.

From the Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

We describe the prevalence and potential significance of deep medullary vein engorgement on SWI in patients with neurosarcoidosis, a finding that has not been described previously. Engorgement was evaluated for possible associations with meningeal or perivascular disease, intracranial hemorrhage, and venous thrombosis, as well as with modified Rankin Scale scores at the time of MR imaging and at follow-up. Deep medullary vein engorgement was seen in 7 of 21 patients and was more common in men. Read More

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http://dx.doi.org/10.3174/ajnr.A5783DOI Listing
November 2018
14 Reads

[Neuroimmunology and rheumatology: overlap and differential diagnoses].

Authors:
C Trebst T Kümpfel

Nervenarzt 2018 Oct;89(10):1095-1105

Institut für klinische Neuroimmunologie, Klinikum Großhadern, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, München, Deutschland.

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are chronic inflammatory diseases of the central nervous system (CNS). They may cause inflammation in the brain, spinal cord and optic nerve. Both conditions must be differentiated from CNS manifestations of other systemic autoimmune diseases such as systemic lupus erythematosus (SLE), Sjögren's syndrome, autoinflammtory diseases and sarcoidosis, since amongst others myelitis and optic nerve inflammation may also occur in these conditions. Read More

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http://dx.doi.org/10.1007/s00115-018-0597-yDOI Listing
October 2018
3 Reads

Application of the modified Zajicek criteria to diagnose probable spinal cord neurosarcoidosis.

Clin Case Rep 2018 Sep 10;6(9):1718-1722. Epub 2018 Jul 10.

Department of Neurology Royal Free Hospital London UK.

Neurosarcoidosis represents a significant diagnostic challenge, as clinical features overlap with other neuroinflammatory conditions, and biopsy of affected neuronal tissue is often high risk or not feasible. Here we highlight application of the modified Zajicek criteria to diagnose probable spinal neurosarcoidosis in the absence of histology from affected neuronal tissue. Read More

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http://dx.doi.org/10.1002/ccr3.1712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132158PMC
September 2018
3 Reads

Optic Neuropathy and Macular Ischemia Associated with Neurosarcoidosis: A Case Report.

Turk J Ophthalmol 2018 Aug 4;48(4):202-205. Epub 2018 Sep 4.

University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Ophthalmology Clinic, İstanbul, Turkey.

In this study, we present a case of bilateral optic neuropathy and macular ischemia in the right eye associated with neurosarcoidosis. A 26-year-old woman presented to our clinic with complaints of bilateral blurred vision. Bilateral granulomatous anterior uveitis, vitritis, optic neuropathy, and macular ischemia were detected in the right eye in slit-lamp examination. Read More

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http://dx.doi.org/10.4274/tjo.49799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126102PMC
August 2018
19 Reads

Neurosarcoidosis following Immune Checkpoint Inhibition.

Case Rep Oncol 2018 May-Aug;11(2):521-526. Epub 2018 Jul 27.

Department of Neurology, Duke University, Durham, North Carolina, USA.

Recently, immune checkpoint inhibitors have revolutionized cancer care by enhancing anti-tumor immunity. However, by virtue of stimulating the immune system, they can lead to immune-related adverse events (irAEs). Neurologic irAEs are uncommon but are becoming increasingly recognized and can be quite serious or even fatal. Read More

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http://dx.doi.org/10.1159/000491599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120397PMC
July 2018
4 Reads

Neurosarcoidosis Mimics High-Grade Glioma in Dynamic 18F-FET PET Due to LAT Expression.

Clin Nucl Med 2018 Nov;43(11):840-841

Institute of Clinical Neuroimmunology, and.

We present a 45-year-old man with newly generalized tonic-clonic seizures due to a contrast-enhancing frontal lesion with perifocal edema suggestive for high-grade glioma (HGG). For further evaluation, a dynamic F-FET PET scan was performed, which showed high F-FET-uptake with early peak and constantly decreasing time-activity curves, a characteristic feature of HGG. Stereotactic biopsy and histological evaluation excluded a neoplastic lesion but confirmed a manifestation of neurosarcoidosis with strong expression of the L-amino-acid-transporter considered responsible for F-FET-uptake. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002266DOI Listing
November 2018

Co-ocurrence of neurosarcoidosis and intrathecal reactivation of Epstein-Barr virus.

Mult Scler Relat Disord 2018 10 24;25:297-299. Epub 2018 Aug 24.

Alabama College of Osteopathic Medicine (ACOM), United States.

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http://dx.doi.org/10.1016/j.msard.2018.08.021DOI Listing
October 2018
67 Reads

Definition and Consensus Diagnostic Criteria for Neurosarcoidosis: From the Neurosarcoidosis Consortium Consensus Group.

JAMA Neurol 2018 Dec;75(12):1546-1553

Department of Medicine, University of Cincinnati, Cincinnati, Ohio.

Importance: The Neurosarcoidosis Consortium Consensus Group, an expert panel of physicians experienced in the management of patients with sarcoidosis and neurosarcoidosis, engaged in an iterative process to define neurosarcoidosis and develop a practical diagnostic approach to patients with suspected neurosarcoidosis. This panel aimed to develop a consensus clinical definition of neurosarcoidosis to enhance the clinical care of patients with suspected neurosarcoidosis and to encourage standardization of research initiatives that address this disease.

Observations: The work of this collaboration included a review of the manifestations of neurosarcoidosis and the establishment of an approach to the diagnosis of this disorder. Read More

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2018.2295DOI Listing
December 2018
11 Reads

A Case of Neurosarcoidosis-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone Diagnosed with Neuroendoscopy.

Case Rep Med 2018 6;2018:9496149. Epub 2018 Aug 6.

Department of Neurosurgery, Saitama Sekishinkai Hospital, Saitama, Japan.

We treated a patient with neurosarcoidosis, which caused the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), in whom diagnosis was performed using neuroendoscopy. The patient was a 56-year-old female who was hospitalized for hyponatremia and diagnosed with SIADH based on a detailed examination. During the course, she developed impaired consciousness due to acute hydrocephalus, which improved after ventricular drainage. Read More

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http://dx.doi.org/10.1155/2018/9496149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109485PMC
August 2018
9 Reads

Neurosarcoidosis Presenting with Obstructive Hydrocephalus Successfully Treated with Endoscopic Third Ventriculostomy.

Intern Med 2019 Jan 24;58(1):105-108. Epub 2018 Aug 24.

Department of Pathology, Shizuoka General Hospital, Japan.

A 58-year-old Japanese woman complained of unstable gait and dizziness lasting for a month. She had been diagnosed histologically with pulmonary and cutaneous sarcoidosis and attended outpatient clinics for routine checkups. Head computed tomography and magnetic resonance imaging (MRI) indicated obstructive hydrocephalus caused by a contrast-enhanced lesion in the cerebral aqueduct. Read More

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http://dx.doi.org/10.2169/internalmedicine.1259-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367092PMC
January 2019
2 Reads

Clinical, imaging, and histological presentations and outcomes of stroke related to sarcoidosis.

J Neurol 2018 Oct 14;265(10):2333-2341. Epub 2018 Aug 14.

Service de Médecine Interne 2, Institut e3m, Centre National de Référence Maladies Systémiques Rares, Sorbonne Université, Faculté de Médecine, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, 47-83 Boulevard de l'hôpital, 75651, Paris Cedex 13, France.

Objectives: Clinical involvement of the nervous system is uncommon during sarcoidosis. Cerebrovascular events are rarely reported during sarcoidosis and may be confused with primary angiitis of the central nervous system. The characteristics and outcomes of cerebrovascular events during sarcoidosis have not been well-evaluated. Read More

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http://dx.doi.org/10.1007/s00415-018-9001-xDOI Listing
October 2018
16 Reads

Clinical diagnostic utility of contrast-enhanced three-dimensional fluid-attenuated inversion recovery for selection of brain biopsy sites in neurosarcoidosis: A case report.

Clin Neurol Neurosurg 2018 Oct 4;173:101-104. Epub 2018 Aug 4.

Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.

Neurosarcoidosis is difficult to diagnose, because definite diagnosis requires detailed histology of the central nervous system. Three-dimensional contrast-enhanced fluid-attenuated inversion recovery (CE-FLAIR) is more useful for detecting leptomeningeal lesions compared with 3D CE-T1 weighted imaging. However, the clinical diagnostic utility of 3D CE-FLAIR for neurosarcoidosis is unclear. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.08.006DOI Listing
October 2018
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Neurosarcoidosis: clinical characteristics, diagnosis, and treatment in eight Chinese patients.

Neurol Sci 2018 Oct 7;39(10):1725-1733. Epub 2018 Aug 7.

Department of Neurology, Xuan Wu Hospital, Capital Medical University, Changchun Street 45, Xicheng District, Beijing, 100053, People's Republic of China.

Neurosarcoidosis is relatively rare and has diverse manifestations. The clinical characteristics, diagnosis, treatment, and outcome for neurosarcoidosis in China are poorly understood. We retrospectively analyzed the clinical features, laboratory and imaging results, treatment, and outcomes in patients who met the criteria for definite or probable neurosarcoidosis in Xuan Wu Hospital of Capital Medical University from 2000 to 2015. Read More

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http://dx.doi.org/10.1007/s10072-018-3491-2DOI Listing
October 2018
13 Reads

Delayed onset of neurosarcoidosis after concurrent ipilimumab/nivolumab therapy.

J Immunother Cancer 2018 Jul 31;6(1):77. Epub 2018 Jul 31.

Division of Medical Oncology, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27701, USA.

Background: Immune checkpoint inhibitors have transformed the treatment landscape for many cancers, including metastatic melanoma, but have also opened the door for a diverse variety of immune-related adverse effects.

Case Presentation: We describe the first reported case of presumed neurosarcoidosis as an immune-related adverse effect that developed nearly a year after discontinuation of treatment with combination ipilimumab and nivolumab for recurrent metastatic melanoma. The patient was noted to develop clinical signs consistent with systemic sarcoidosis shortly after the initiation of treatment and underwent a biopsy of hilar lymphadenopathy that confirmed sarcoidosis and after which immunotherapy was discontinued. Read More

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http://dx.doi.org/10.1186/s40425-018-0390-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069826PMC
July 2018
5 Reads

Neurosarcoidosis Flare with Multifocal Restricted Diffusion: Stroke, Inflammation, or Both?

J Stroke Cerebrovasc Dis 2018 Oct 25;27(10):e230-e232. Epub 2018 Jul 25.

Neurological Institute's Mellen Center for Multiple Sclerosis, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

Sarcoidosis is a multisystem granulomatous disease that can cause a wide range of neurologic symptoms. Leptomeningeal enhancement is frequently described but reports of stroke-like symptoms or the appearance of ischemia on magnetic resonance imaging are rare. We present a case of a patient with both leptomeningeal enhancement and multifocal restricted diffusion in a patient with sarcoidosis. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.05.043DOI Listing
October 2018
3 Reads

Cerebrovascular manifestations in neurosarcoidosis: how common are they and does perivascular enhancement matter?

Clin Radiol 2018 Oct 30;73(10):907.e15-907.e23. Epub 2018 Jun 30.

Division of Neuroradiology, Michigan Radiology, University of Michigan, Ann Arbor, MI, USA.

Aim: To determine the occurrence of ischaemic and haemorrhagic events in patients with neurosarcoidosis at presentation and follow-up and to evaluate its association with perivascular enhancement.

Materials And Methods: The MRI findings in patients with neurosarcoidosis who presented to our institute from 2002-2017 were retrospectively reviewed, with emphasis on cerebrovascular events. A chi-squared test was used to evaluate the statistical association with presence of perivascular enhancement. Read More

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http://dx.doi.org/10.1016/j.crad.2018.05.018DOI Listing
October 2018
2 Reads