113 results match your criteria Neuroretinitis Diffuse Unilateral Subacute


Short-term oral albendazole therapy for diffuse unilateral subacute neuroretinitis: A case report.

Am J Ophthalmol Case Rep 2021 Jun 6;22:101054. Epub 2021 Mar 6.

University of Puerto Rico, Medical Sciences Campus, Department of Ophthalmology, San Juan, PR, USA.

Purpose: To report on a case of diffuse unilateral subacute neuroretinitis (DUSN) that was successfully treated with a short course of oral albendazole.

Observations: A 51-year-old male presented with severe visual loss secondary to DUSN associated with a positive serology. Because the parasite could not be detected on fundoscopy, first-line treatment with photocoagulation could not be administered. Read More

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Surgical Removal of Intraocular Parasite in a Patient With Diffuse Unilateral Subacute Neuroretinitis.

Ophthalmic Surg Lasers Imaging Retina 2020 Dec;51(12):733-735

Diffuse unilateral subacute neuroretinitis (DUSN) is a rare ocular infectious disease caused by migrating larvae of a nematode. DUSN is often a diagnostic challenge as it is difficult to identify the pathogenic nematode on funduscopic examination because it moves frequently and often resides within the subretinal space. Herein, the authors present a patient with unilateral, chronic visual loss who was noted to have a live, motile worm within the vitreous cavity. Read More

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December 2020

Multimodal imaging-guided diagnosis, management and follow-up of a case of diffuse unilateral subacute neuroretinitis.

BMJ Case Rep 2020 Apr 15;13(4). Epub 2020 Apr 15.

Department of Vitreo-retina, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

A 45-year-old woman presented with diminished vision in the left eye. Visual acuity was 6/9 and fundus showed a very large live nematode near the macula along with inflammatory outer retinal lesions in the periphery. We diagnosed the case as diffuse unilateral subacute neuroretinitis and treated with immediate focal photocoagulation of the worm along with oral antihelminthic drugs and corticosteroids. Read More

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Optical Coherence Tomography Angiography Findings in Diffuse Unilateral Subacute Neuroretinitis.

Ophthalmic Surg Lasers Imaging Retina 2020 02;51(2):76-83

Background And Objective: To report a unique case series of diffuse unilateral subacute neuroretinitis (DUSN) patients imaged with optical coherence tomography angiography (OCTA).

Patients And Methods: In this retrospective case series, multimodal imaging was performed in four patients with DUSN at the time of patient visit. The study patients underwent standard clinical treatment for DUSN. Read More

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February 2020

Diffuse unilateral subacute neuroretinitis: review article.

J Ophthalmic Inflamm Infect 2019 Dec 27;9(1):23. Epub 2019 Dec 27.

Research Laboratory of Infectious Diseases in Ophthalmology, National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Diffuse unilateral subacute neuroretinitis (DUSN) is an ocular infectious disease that can lead to severe visual impairment and blindness. It usually occurs in healthy young individuals and depending on the stage of the disease, it may present as vitritis, multifocal gray-white lesions in the outer retina, and derangement of the retinal pigment epithelium, narrowing of the retinal vessels and optic atrophy. Parasites of different sizes and species have been proposed as the etiologic agent of DUSN, including Ancylostoma caninum, Toxocara canis, and others. Read More

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December 2019

Diffuse Unilateral Subacute Neuroretinitis Evolving With Submacular Granuloma.

Ocul Immunol Inflamm 2021 Jan 24;29(1):90-94. Epub 2019 Oct 24.

Research Laboratory of Infectious Diseases in Ophthalmology, National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

DUSN is an infectious ocular disease that can lead to severe visual impairment and blindness. It usually occurs in young healthy individuals and depending on the stage of the disease, clinical presentation may range from mild vitritis and multifocal gray-white lesions in outer retina to optic atrophy.Parasites of different sizes and species have been proposed as the etiological agent of this disease. Read More

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January 2021

Commentary: Role of PASCAL and optical coherence tomography angiograpgy in the treatment of diffuse unilateral subacute neuroretinitis caused by large live motile worm.

Indian J Ophthalmol 2019 09;67(9):1496-1497

Department of Vitreo-Retinal Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

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September 2019

Role of PASCAL and optical coherence tomography angiograpgy in the treatment of diffuse unilateral subacute neuroretinitis caused by large live motile worm.

Indian J Ophthalmol 2019 09;67(9):1494-1496

Vitreoretina and Uveitis Services, L V Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India.

A 46-year-old male presented with best corrected visual acuity (BCVA) of 20/125 in his right eye. Fundus showed disc edema, multiple yellow outer retinal crops, macular edema and a live motile worm in the subretinal space. Diagnosis of diffuse unilateral subacute neuroretinitis (DUSN) was made and pattern scanning laser photocoagulation (PSLP) was performed along with administration of oral albendazole, diethylcarbamazine and corticosteroids. Read More

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September 2019

Significant Vision Recovery after Early Treatment of Diffuse Unilateral Subacute Neuroretinitis.

Ophthalmol Retina 2019 08;3(8):709

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York; Department of Pathology & Cell Biology, Stem Cell Initiative, Columbia University College of Physicians and Surgeons, New York, New York.

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Diffuse unilateral subacute neuroretinitis.

Oman J Ophthalmol 2019 Jan-Apr;12(1):59-61

Department of Retina, Aravind Eye Hospital, Puducherry, India.

Diffuse unilateral subacute neuroretinitis (DUSN) is a subacute outer retinal inflammation due to the presence of a subretinal worm. The worm is identifiable in only 30% of the cases. The identification of the worm and laser photocoagulation of the worm remains the mainstay of treatment. Read More

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February 2019

Diffuse Unilateral Subacute Neuroretinitis (DUSN).

Adv Exp Med Biol 2018;1085:239-241

Department of Ophthalmology, Columbia University, Edward S. Harkness Eye Institute, NewYork-Presbyterian Hospital, New York, NY, USA.

Diffuse unilateral subacute neuroretinitis (DUSN) is caused by a subretinal live and mobile nematode. Acute phase: Patients usually present with severe pain, decreased vision, vitritis/papillitis, and tracks of grayish-white lesions-and a live nematode. Late phase: Arterial narrowing, optic atrophy, diffuse disruption of the retinal pigment epithelium (RPE), with severe visual loss. Read More

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Case report: a case of diffuse unilateral subacute neuroretinitis (DUSN) in a child.

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):218. Epub 2018 Sep 14.

Department of Ophthalmology, Royal Victoria Hospital, 274 Grosvenor Road, Belfast, BT12 6BA, Northern Ireland.

Background: Diffuse unilateral subacute neuroretinitis (DUSN) is a rare cause of posterior uveitis in the United Kingdom. It typically presents unilaterally in children and young adults but rarely bilateral cases have been reported. It is also rare to have multiple worms in the same eye causing the clinical picture. Read More

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September 2018

Ultrawide field imaging with navigable magnifier for diagnosis of diffuse unilateral subacute neuroretinitis.

BMJ Case Rep 2017 Dec 20;2017. Epub 2017 Dec 20.

Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India.

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December 2017

Optical coherence tomography angiography of diffuse unilateral subacute neuroretinitis.

Am J Ophthalmol Case Rep 2017 Sep 22;7:91-94. Epub 2017 Jun 22.

Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA, United States.

Purpose: Diffuse unilateral subacute neuroretinitis (DUSN) is often a challenging diagnosis to make. We present a DUSN case with its multimodal imaging to aid in the diagnosis, emphasizing the observations on optical coherence tomography angiography (OCTA).

Observations: The evolution of a DUSN case is presented. Read More

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September 2017

Observation and Clinical Pattern in Patients with White Dot Syndromes: The Role of Color Photography in Monitoring Ocular Changes in Long-Term Observation.

Med Sci Monit 2017 Mar 2;23:1106-1115. Epub 2017 Mar 2.

Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND The aim of this study was to assess the clinical course and distinctive features of different white dot syndromes (WDS) in patients attending the Ophthalmology Department, Medical University of Warsaw in the years 1995-2015. MATERIAL AND METHODS Sixty-two (62) patients (43 females and 19 males), aged 18 to 77 years, referred with a WDS were included in this prospective study, with observation period ranging from 5 months to 16 years. All patients underwent a complete ophthalmological examination and multimodal imaging studies. Read More

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Diffuse Unilateral Subacute Neuroretinitis Caused by Ancylostoma Hookworm.

Emerg Infect Dis 2017 02;23(2):343-344

Diffuse unilateral subacute neuroretinitis is an ocular infectious disease caused by several distinct nematodes. Definite identification of the involved nematodes is rarely achieved. We report on the molecular-based genetic identification of an Ancylostoma ceylanicum hookworm implicated in a case of diffuse unilateral subacute neuroretinitis in a child. Read More

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February 2017

Ocular parasitoses: A comprehensive review.

Surv Ophthalmol 2017 Mar - Apr;62(2):161-189. Epub 2016 Oct 6.

Department of Ophthalmology and Visual sciences, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

Parasitic infections of the eyes are a major cause of ocular diseases across the globe. The causative agents range from simple organisms such as unicellular protozoans to complex metazoan helminths. The disease spectrum varies depending on the geographic location, prevailing hygiene, living and eating habits of the inhabitants, and the type of animals that surround them. Read More

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Diffuse Unilateral Subacute Neuroretinitis From Raccoon Exposure Resistant to Laser Photocoagulation.

Ophthalmic Surg Lasers Imaging Retina 2016 07;47(7):686-90

Diffuse unilateral subacute neuroretinitis (DUSN) is an ocular disease caused by a subretinal nematode worm. The authors present a unique case of a 9-year-old girl with DUSN due to presumed Baylisascaris procyonis, given the size of the worm and previous raccoon exposure. The worm was located in the inner retina and treated with laser photocoagulation and albendazole. Read More

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Successful Management of Diffuse Unilateral Subacute Neuroretinitis with Anthelmintics, and Intravitreal Triamcinolone followed by Laser Photocoagulation.

J Ophthalmic Vis Res 2016 Jan-Mar;11(1):116-9

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Diffuse unilateral subacute neuroretinitis (DUSN), a form of posterior uveitis, is secondary to the presence of a highly motile nematode in the intraretinal or subretinal space. Herein, we report a case of DUSN that was successfully managed by an intravitreal injection of triamcinolone and laser therapy.

Case Report: A middle-aged man with complaint of decreased vision and marked unilateral vitritis and neuroretinitis. Read More

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Update on Baylisascariasis, a Highly Pathogenic Zoonotic Infection.

Clin Microbiol Rev 2016 Apr;29(2):375-99

Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA.

Baylisascaris procyonis, the raccoon roundworm, infects a wide range of vertebrate animals, including humans, in which it causes a particularly severe type of larva migrans. It is an important cause of severe neurologic disease (neural larva migrans [NLM]) but also causes ocular disease (OLM; diffuse unilateral subacute neuroretinitis [DUSN]), visceral larva migrans (VLM), and covert/asymptomatic infections. B. Read More

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Neuroretinitis with dual infections.

Int Med Case Rep J 2015 19;8:255-8. Epub 2015 Oct 19.

Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

A 22-year-old Malay female presented with left eye floaters for 2 weeks, associated with temporal visual field defect and metamorphopsia for 3 days. She has a guinea pig and a hedgehog at home, but denied being bitten or scratched by them. Her visual acuity at presentation was 6/12 on the left eye and 6/6 on the right eye. Read More

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November 2015

Clinical experience in treatment of diffuse unilateral subretinal neuroretinitis.

Clin Ophthalmol 2015 28;9:1799-805. Epub 2015 Sep 28.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Purpose: To describe the clinical features, management, and outcomes of patients with diffuse unilateral subacute neuroretinitis (DUSN).

Methods: A noncomparative, consecutive analysis of case series from two tertiary care campuses of LV Prasad Eye Institute, India, between January 2011 and April 2014 was performed. Medical records of the patients presenting with DUSN (early or late stage) were reviewed. Read More

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October 2015

Baylisascaris procyonis and Herpes Simplex Virus 2 Coinfection Presenting as Ocular Larva Migrans with Granuloma Formation in a Child.

Am J Trop Med Hyg 2015 Sep 29;93(3):612-4. Epub 2015 Jun 29.

Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, New York; Department of Pediatrics, Albert Einstein College of Medicine, New York City, New York; Department of Pathology, Albert Einstein College of Medicine, Bronx, New York; Department of Medicine, Albert Einstein College of Medicine, and Jacobi Medical Center, Bronx, New York; Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana; Virology Laboratory, University of Iowa Children's Hospital, Iowa City, Iowa

Ocular Baylisascaris procyonis infection results from ingestion of infective eggs of B. procyonis, the raccoon ascarid. Herpes simplex virus type 2 (HSV-2) infection of the retina is the result of either primary infection or reactivated disease. Read More

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September 2015

Diffuse unilateral subacute neuroretinitis in a healthy Korean male: the first case report in Korea.

J Korean Med Sci 2015 Mar 16;30(3):346-9. Epub 2015 Feb 16.

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.

A 52-yr-old male was referred for progressive visual loss in the left eye. The decimal best-corrected visual acuity (BCVA) was 0.01. Read More

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Subretinal Thelazia-induced diffuse unilateral subacute neuroretinitis.

JAMA Ophthalmol 2014 Jul;132(7):896-8

Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands.

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Evaluation of patients with diffuse unilateral subacute neuroretinitis by spectral domain optical coherence tomography with enhanced depth imaging.

Clin Ophthalmol 2014 5;8:1081-7. Epub 2014 Jun 5.

Federal University of São Paulo, São Paulo, Federative Republic of Brazil, Brazil.

Background: The purpose of this study was to determine the value of spectral domain optical coherence tomography (SD-OCT) in assessing patients with diffuse unilateral subacute neuroretinitis (DUSN).

Methods: This was an observational case series with clinical imaging correlation performed at the Retina and Vitreous Institute of Londrina and State University of Londrina, Paraná, Brazil. The series comprised ten consecutive patients with a confirmed diagnosis of DUSN, ie, seven patients with late-stage disease and three with early-stage disease, who were assessed by SD-OCT for mean macular, retinal nerve fiber layer, and choroidal thickness using enhanced depth imaging software. Read More

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Structural and functional retinal changes in eyes with DUSN.

Retina 2014 Aug;34(8):1675-82

*Medical Retina Department, Uevitis Unit, Moorfields Eye Hospital, London, United Kingdom; and †Electrophysiology Department, Institute of Ophthalmology, University College London, London, United Kingdom.

Purpose: To report novel spectral domain optical coherence tomography and electrophysiologic findings in diffuse unilateral subacute neuroretinitis.

Methods: Six patients with a diagnosis of diffuse unilateral subacute neuroretinitis were retrospectively ascertained. All patients had received oral treatment with albendazole; resolution of the inflammatory lesions without subsequent relapse was noted. Read More

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[Diffuse unilateral subacute neuroretinitis (DUSN): current update].

Arq Bras Oftalmol 2013 Jul-Aug;76(4):256-60

Diffuse unilateral subacute neuroretinitis (DUSN) is a form of uveitis that can potentially lead to blindness. In Brazil and other parts of South America, diffuse unilateral subacute neuroretinitis is an important cause of posterior uveitis in children and healthy young adults. If diagnosed and treated in early stage, allows a resolution of symptoms with improvement of visual acuity. Read More

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Baylisascaris larva migrans.

Handb Clin Neurol 2013 ;114:251-62

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.

Baylisascaris procyonis is a roundworm of the raccoon found primarily in North America but also known to occur in other parts of the world including South America, Europe, and Japan. Migration of the larvae of this parasite is recognized as a cause of clinical neural larva migrans (NLM) in humans, primarily children. It is manifested as meningoencephalitis associated with marked eosinophilia of the cerebrospinal fluid and peripheral blood. Read More

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Diffuse unilateral subacute neuroretinitis.

J Pediatr Ophthalmol Strabismus 2013 Jul-Aug;50(4):204-12. Epub 2012 Dec 18.

Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Diffuse unilateral subacute neuroretinitis (DUSN) is a usually unilateral inflammatory disease characterized by an insidious, usually severe loss of peripheral and central vision. Clinical characteristics are manifested in early and late stages. Parasites of different sizes and several species of nematodes have been reported as the etiology of DUSN without conclusive evidence about the specific agent. Read More

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