1,309 results match your criteria Neurorehabilitation and Neural Repair[Journal]


rTMS Ameliorates Prenatal Stress-Induced Cognitive Deficits in Male-Offspring Rats Associated With BDNF/TrkB Signaling Pathway.

Neurorehabil Neural Repair 2019 Apr;33(4):271-283

1 Nankai University, Tianjin, People's Republic of China.

Background: Growing evidences suggest that brain-derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) plays a key role in the regulation of hippocampal synaptic plasticity in a prenatal stress (PNS) rat model. Repetitive transcranial magnetic stimulation (rTMS) is currently being acknowledged to affect attention and memory in both preclinical and clinical studies, although the mechanism is still unclear.

Objective: The current study aimed to explore whether a whole brain rTMS (5 Hz, 14 days) could ameliorate cognitive dysfunction-induced PNS in male offspring, and examine if the positive effect of rTMS was associated with the BDNF/TrkB signaling in the hippocampus. Read More

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http://dx.doi.org/10.1177/1545968319834898DOI Listing

Cortical Thickness and Cognitive Performance After Out-of-Hospital Cardiac Arrest.

Neurorehabil Neural Repair 2019 Apr;33(4):296-306

1 University Hospital of North Norway, Tromsø, Norway.

Background: Cognitive impairment is common in long-term survivors of out-of-hospital cardiac arrest (OHCA) but corresponding neuroimaging data are lacking.

Objectives: This study explored the relationship among the cortical brain structure, cognitive performance, and clinical variables after OHCA.

Methods: Three months after resuscitation, 13 OHCA survivors who had recovered from a coma to living independently and 19 healthy controls were assessed by cerebral magnetic resonance imaging and neuropsychological tests quantifying memory, fine-motor coordination, and attention/executive functions. Read More

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http://dx.doi.org/10.1177/1545968319834904DOI Listing
April 2019
1 Read

Therapeutic Role of Transcranial Direct Current Stimulation in Alzheimer Disease Patients: Double-Blind, Placebo-Controlled Clinical Trial.

Neurorehabil Neural Repair 2019 Apr 3:1545968319840285. Epub 2019 Apr 3.

1 Assiut University Hospital, Egypt.

Objective: To explore the neuropsychological effects and levels of tau protein (TAU), amyloid β 1-42 (Aβ 1-42), and lipid peroxidase after 10 sessions of anodal transcranial direct current stimulation (tDCS) in patients with mild to moderate Alzheimer disease (AD).

Patients And Methods: A total of 46 consecutive patients with probable AD participated in this study. They were classified randomly into 2 equal groups: active versus sham. Read More

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http://dx.doi.org/10.1177/1545968319840285DOI Listing
April 2019
2 Reads

Systematic Review Investigating the Effects of Nonpharmacological Interventions During Sleep to Enhance Physical Rehabilitation Outcomes in People With Neurological Diagnoses.

Neurorehabil Neural Repair 2019 Apr 2:1545968319840288. Epub 2019 Apr 2.

1 University of Maryland School of Medicine, Baltimore, MD, USA.

Objective: Conduct a systematic review of nonpharmacological interventions applied during sleep to enhance physical rehabilitation outcomes of individuals with a neurological diagnosis.

Data Sources: Three online databases were searched for original research.

Study Selection: Intervention studies were included that used outcome measures of impairment, activity, and/or participation. Read More

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http://dx.doi.org/10.1177/1545968319840288DOI Listing
April 2019
4 Reads

Effects of Dopamine on Motor Recovery and Training in Adults and Children With Nonprogressive Neurological Injuries: A Systematic Review.

Neurorehabil Neural Repair 2019 Mar 27:1545968319837289. Epub 2019 Mar 27.

1 National Institutes of Health, Bethesda, MD, USA.

Background: The strong link between dopamine and motor learning has been well-established in the animal literature with similar findings reported in healthy adults and the elderly.

Objective: We aimed to conduct the first, to our knowledge, systematic review of the literature on the evidence for the effects of dopaminergic medications or genetic variations in dopamine transmission on motor recovery or learning after a nonprogressive neurological injury.

Methods: A PubMed search was conducted up until April 2018 for all English articles including participants with nonprogressive neurological injury such as cerebral palsy, stroke, spinal cord injury, and traumatic brain injury; quantitative motor outcomes; and assessments of the dopaminergic system or medications. Read More

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http://dx.doi.org/10.1177/1545968319837289DOI Listing
March 2019
1 Read

The Relationship Between Enhanced Reticulospinal Outflow and Upper Limb Function in Chronic Stroke Patients.

Neurorehabil Neural Repair 2019 Mar 27:1545968319836233. Epub 2019 Mar 27.

3 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

Background: Recent evidence from both monkey and human studies suggests that the reticulospinal tract may contribute to recovery of arm and hand function after stroke. In this study, we evaluated a marker of reticulospinal output in stroke survivors with varying degrees of motor recovery.

Methods: We recruited 95 consecutive stroke patients presenting 6 months to 12 years after their index stroke, and 19 heathy control subjects. Read More

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http://dx.doi.org/10.1177/1545968319836233DOI Listing
March 2019
1 Read

Camera-Based Mirror Visual Input for Priming Promotes Motor Recovery, Daily Function, and Brain Network Segregation in Subacute Stroke Patients.

Neurorehabil Neural Repair 2019 Apr 25;33(4):307-318. Epub 2019 Mar 25.

1 Huashan Hospital, Fudan University, Shanghai, China.

Background: Camera technique-based mirror visual feedback (MVF) is an optimal interface for mirror therapy. However, its efficiency for stroke rehabilitation and the underlying neural mechanisms remain unclear.

Objective: To investigate the possible treatment benefits of camera-based MVF (camMVF) for priming prior to hand function exercise in subacute stroke patients, and to reveal topological reorganization of brain network in response to the intervention. Read More

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http://dx.doi.org/10.1177/1545968319836207DOI Listing
April 2019
1 Read

Poststroke Aphasia Rehabilitation: Why All Talk and No Action?

Neurorehabil Neural Repair 2019 Apr 22;33(4):235-244. Epub 2019 Mar 22.

3 Moss Rehabilitation Research Institute, Elkins Park, PA, USA.

There is ample agreement in the scientific literature, across diverse areas of study, that suggests that language and movement are interrelated. In particular, it is widely held that the upper limb and hand play a key role in language use. Aphasia, a common, disabling language disorder frequently associated with stroke, requires new restorative methods. Read More

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http://journals.sagepub.com/doi/10.1177/1545968319834901
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http://dx.doi.org/10.1177/1545968319834901DOI Listing
April 2019
8 Reads

Ultrasound Structural Changes in Triceps Surae After a 1-Year Daily Self-stretch Program: A Prospective Randomized Controlled Trial in Chronic Hemiparesis.

Neurorehabil Neural Repair 2019 Apr 22;33(4):245-259. Epub 2019 Mar 22.

1 EA 7377 BIOTN, Université Paris-Est Créteil (UPEC), France.

Introduction: The effects of long-term stretching (>6 months) in hemiparesis are unknown. This prospective, randomized, single-blind controlled trial compared changes in architectural and clinical parameters in plantar flexors of individuals with chronic hemiparesis following a 1-year guided self-stretch program, compared with conventional rehabilitation alone.

Methods: Adults with chronic stroke-induced hemiparesis (time since lesion >1 year) were randomized into 1 of 2, 1-year rehabilitation programs: conventional therapy (CONV) supplemented with the Guided Self-rehabilitation Contract (GSC) program, or CONV alone. Read More

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http://dx.doi.org/10.1177/1545968319829455DOI Listing
April 2019
1 Read

Myoelectric Computer Interface Training for Reducing Co-Activation and Enhancing Arm Movement in Chronic Stroke Survivors: A Randomized Trial.

Neurorehabil Neural Repair 2019 Apr 19;33(4):284-295. Epub 2019 Mar 19.

1 Northwestern University, Chicago, IL, USA.

Background: Abnormal muscle co-activation contributes to impairment after stroke. We developed a myoelectric computer interface (MyoCI) training paradigm to reduce abnormal co-activation. MyoCI provides intuitive feedback about muscle activation patterns, enabling decoupling of these muscles. Read More

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http://dx.doi.org/10.1177/1545968319834903DOI Listing
April 2019
1 Read

Self-efficacy and Reach Performance in Individuals With Mild Motor Impairment Due to Stroke.

Neurorehabil Neural Repair 2019 Apr 18;33(4):319-328. Epub 2019 Mar 18.

3 University of Southern California, Los Angeles, CA, USA.

Background: Persistent deficits in arm function are common after stroke. An improved understanding of the factors that contribute to the performance of skilled arm movements is needed. One such factor may be self-efficacy (SE). Read More

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http://dx.doi.org/10.1177/1545968319836231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462237PMC
April 2019
3 Reads

Searching for the "Active Ingredients" in Physical Rehabilitation Programs Across Europe, Necessary to Improve Mobility in People With Multiple Sclerosis: A Multicenter Study.

Neurorehabil Neural Repair 2019 Apr 17;33(4):260-270. Epub 2019 Mar 17.

3 Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.

Background: Physical rehabilitation programs can lead to improvements in mobility in people with multiple sclerosis (PwMS).

Objective: To identify which rehabilitation program elements are employed in real life and how they might affect mobility improvement in PwMS.

Methods: Participants were divided into improved and nonimproved mobility groups based on changes observed in the Multiple Sclerosis Walking Scale-12 following multimodal physical rehabilitation programs. Read More

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http://dx.doi.org/10.1177/1545968319834893DOI Listing
April 2019
3.976 Impact Factor

Synergistic Benefits of Combined Aerobic and Cognitive Training on Fluid Intelligence and the Role of IGF-1 in Chronic Stroke.

Neurorehabil Neural Repair 2019 Mar 28;33(3):199-212. Epub 2019 Feb 28.

2 Dalhousie University, Halifax, Nova Scotia, Canada NL, Canada.

Background: Paired exercise and cognitive training have the potential to enhance cognition by "priming" the brain and upregulating neurotrophins.

Methods: Two-site randomized controlled trial. Fifty-two patients >6 months poststroke with concerns about cognitive impairment trained 50 to 70 minutes, 3× week for 10 weeks with 12-week follow-up. Read More

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http://dx.doi.org/10.1177/1545968319832605DOI Listing
March 2019
1 Read

Is Unilateral Spatial Neglect Associated With Motor Recovery of the Affected Upper Extremity Poststroke? A Systematic Review.

Neurorehabil Neural Repair 2019 Mar 20;33(3):179-187. Epub 2019 Feb 20.

2 School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Background And Purpose: Individuals with stroke often present symptoms of multiple domains, such as weakness of the affected upper extremity (UE) and unilateral spatial neglect (USN), which are both associated with poor functional outcome. The aims of this systematic review were to search and review studies that investigated (1) the relationship between USN and affected UE sensorimotor recovery poststroke and (2) the effectiveness of sensorimotor interventions to improve the affected UE in patients with USN.

Methods: An electronic search of databases (MEDLINE, EMBASE, CINAHL and Cochrane CENTRAL) was conducted using a combination of the following terms: stroke, USN, and affected UE. Read More

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http://dx.doi.org/10.1177/1545968319832606DOI Listing
March 2019
4 Reads

Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection.

Neurorehabil Neural Repair 2019 Mar 19;33(3):225-231. Epub 2019 Feb 19.

1 University of California, Los Angeles, CA, USA.

Background: We previously demonstrated that step training leads to reorganization of neuronal networks in the lumbar spinal cord of rodents after a hemisection (HX) injury and step training, including increases excitability of spinally evoked potentials in hindlimb motor neurons.

Methods: In this study, we investigated changes in RNA expression and synapse number using RNA-Seq and immunohistochemistry of the lumbar spinal cord 23 days after a mid-thoracic HX in rats with and without post-HX step training.

Results: Gene Ontology (GO) term clustering demonstrated that expression levels of 36 synapse-related genes were increased in trained compared with nontrained rats. Read More

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http://dx.doi.org/10.1177/1545968319829456DOI Listing

Effects of Perturbation-Based Balance Training in Subacute Persons With Stroke: A Randomized Controlled Trial.

Neurorehabil Neural Repair 2019 Mar 15;33(3):213-224. Epub 2019 Feb 15.

1 Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel.

Background: Reactive balance responses are critical for fall prevention. Perturbation-based balance training (PBBT) has shown a positive effect in reducing the risk of falls among older adults and persons with Parkinson's disease.

Objective: To explore the effect of a short-term PBBT on reactive balance responses, performance-based measures of balance and gait and balance confidence. Read More

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http://dx.doi.org/10.1177/1545968319829453DOI Listing

Language as a Predictor of Motor Recovery: The Case for a More Global Approach to Stroke Rehabilitation.

Neurorehabil Neural Repair 2019 Mar 13;33(3):167-178. Epub 2019 Feb 13.

3 Curtin University, Perth, Western Australia, Australia.

Stroke is the third leading cause of death in the developed world and the primary cause of adult disability. The most common site of stroke is the middle cerebral artery (MCA), an artery that supplies a range of areas involved in both language and motor function. As a consequence, many stroke patients experience a combination of language and motor deficits. Read More

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http://dx.doi.org/10.1177/1545968319829454DOI Listing
March 2019
1 Read

Using Vision to Study Poststroke Recovery and Test Hypotheses About Neurorehabilitation.

Neurorehabil Neural Repair 2019 Feb;33(2):87-95

1 University of Rochester, Rochester, NY, USA.

Approximately one-third of stroke patients suffer visual field impairment as a result of their strokes. However, studies using the visual pathway as a paradigm for studying poststroke recovery are limited. In this article, we propose that the visual pathway has many features that make it an excellent model system for studying poststroke neuroplasticity and assessing the efficacy of therapeutic interventions. Read More

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http://dx.doi.org/10.1177/1545968319827569DOI Listing
February 2019

Aerobic Exercise Therapy in Ambulatory Patients With ALS: A Randomized Controlled Trial.

Neurorehabil Neural Repair 2019 Feb;33(2):153-164

1 University Medical Center Utrecht, Netherlands.

Background: Weakness caused by motor neuron degeneration in amyotrophic lateral sclerosis (ALS) may result in avoidance of physical activity, resulting in deconditioning and reduced health-related quality of life (HRQoL).

Objective: To study the effectiveness of aerobic exercise therapy (AET) on disease-specific and generic HRQoL in ambulatory patients with ALS.

Methods: We conducted a multicenter, assessor-blinded, randomized controlled trial. Read More

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http://journals.sagepub.com/doi/10.1177/1545968319826051
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http://dx.doi.org/10.1177/1545968319826051DOI Listing
February 2019
9 Reads

Relationship Between Spasticity and Upper-Limb Movement Disorders in Individuals With Subacute Stroke Using Stochastic Spatiotemporal Modeling.

Neurorehabil Neural Repair 2019 Feb;33(2):141-152

1 Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Spasticity is common in patients with stroke, yet current quantification methods are insufficient for determining the relationship between spasticity and voluntary movement deficits. This is partly a result of the effects of spasticity on spatiotemporal characteristics of movement and the variability of voluntary movement. These can be captured by Gaussian mixture models (GMMs). Read More

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http://dx.doi.org/10.1177/1545968319826050DOI Listing
February 2019
1 Read
3.976 Impact Factor

The Influence of Primary Motor Cortex Inhibition on Upper Limb Impairment and Function in Chronic Stroke: A Multimodal Study.

Neurorehabil Neural Repair 2019 Feb;33(2):130-140

1 The University of Auckland, Auckland, New Zealand.

Background: Stroke is a leading cause of adult disability owing largely to motor impairment and loss of function. After stroke, there may be abnormalities in γ-aminobutyric acid (GABA)-mediated inhibitory function within primary motor cortex (M1), which may have implications for residual motor impairment and the potential for functional improvements at the chronic stage.

Objective: To quantify GABA neurotransmission and concentration within ipsilesional and contralesional M1 and determine if they relate to upper limb impairment and function at the chronic stage of stroke. Read More

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http://dx.doi.org/10.1177/1545968319826052DOI Listing
February 2019
1 Read

Brain-Machine Interface in Chronic Stroke: Randomized Trial Long-Term Follow-up.

Neurorehabil Neural Repair 2019 Mar 5;33(3):188-198. Epub 2019 Feb 5.

1 University of Tubingen, Tübingen, Germany.

Background: Brain-machine interfaces (BMIs) have been recently proposed as a new tool to induce functional recovery in stroke patients.

Objective: Here we evaluated long-term effects of BMI training and physiotherapy in motor function of severely paralyzed chronic stroke patients 6 months after intervention.

Methods: A total of 30 chronic stroke patients with severe hand paresis from our previous study were invited, and 28 underwent follow-up assessments. Read More

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http://dx.doi.org/10.1177/1545968319827573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420378PMC
March 2019
4 Reads

Electromyogram-Related Neuromuscular Electrical Stimulation for Restoring Wrist and Hand Movement in Poststroke Hemiplegia: A Systematic Review and Meta-Analysis.

Neurorehabil Neural Repair 2019 Feb 1;33(2):96-111. Epub 2019 Feb 1.

2 Jewish Rehabilitation Hospital Site, Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), Laval, Canada.

Background: Clinical trials have demonstrated some benefits of electromyogram-triggered/controlled neuromuscular electrical stimulation (EMG-NMES) on motor recovery of upper limb (UL) function in patients with stroke. However, EMG-NMES use in clinical practice is limited due to a lack of evidence supporting its effectiveness.

Objective: To perform a systematic review and meta-analysis to determine the effects of EMG-NMES on stroke UL recovery based on each of the International Classification of Functioning, Disability, and Health (ICF) domains. Read More

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http://dx.doi.org/10.1177/1545968319826053DOI Listing
February 2019
2 Reads

Effect of Specific Over Nonspecific VR-Based Rehabilitation on Poststroke Motor Recovery: A Systematic Meta-analysis.

Neurorehabil Neural Repair 2019 Feb 30;33(2):112-129. Epub 2019 Jan 30.

1 Laboratory of Synthetic, Perceptive, Emotive and Cognitive Systems (SPECS), Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Background: Despite the rise of virtual reality (VR)-based interventions in stroke rehabilitation over the past decade, no consensus has been reached on its efficacy. This ostensibly puzzling outcome might not be that surprising given that VR is intrinsically neutral to its use-that is, an intervention is effective because of its ability to mobilize recovery mechanisms, not its technology. As VR systems specifically built for rehabilitation might capitalize better on the advantages of technology to implement neuroscientifically grounded protocols, they might be more effective than those designed for recreational gaming. Read More

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http://dx.doi.org/10.1177/1545968318820169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376608PMC
February 2019
1 Read

Compensation or Recovery? Altered Kinetics and Neuromuscular Synergies Following High-Intensity Stepping Training Poststroke.

Neurorehabil Neural Repair 2019 Jan 29;33(1):47-58. Epub 2018 Dec 29.

1 Indiana University, Indianapolis, IN, USA.

Background: High-intensity, variable stepping training can improve walking speed in individuals poststroke, although neuromuscular strategies used to achieve faster speeds are unclear. We evaluated changes in joint kinetics and neuromuscular coordination following such training; movement strategies consistent with intact individuals were considered evidence of recovery and abnormal strategies indicative of compensation.

Methods: A total of 15 individuals with stroke (duration: 23 ± 30 months) received ≤40 sessions of high-intensity stepping in variable contexts (tasks and environments). Read More

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http://dx.doi.org/10.1177/1545968318817825DOI Listing
January 2019

Full Activation Profiles and Integrity of Corticospinal Pathways in Adults With Bilateral Spastic Cerebral Palsy.

Neurorehabil Neural Repair 2019 Jan 29;33(1):59-69. Epub 2018 Dec 29.

2 University of Alberta, Edmonton, Alberta, Canada.

Background: Dysfunction of corticospinal pathways has been implicated in motor impairments in people with bilateral spastic cerebral palsy (CP). While structural damage to corticospinal pathways in people with CP is known, its impact on the activation of these pathways is not.

Objective: To provide the first, complete activation profile of corticospinal pathways in adults with CP using a full range of transcranial magnetic stimulation (TMS) intensities and voluntary contractions. Read More

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http://dx.doi.org/10.1177/1545968318818898DOI Listing
January 2019
3 Reads

A Single Session of Robot-Controlled Proprioceptive Training Modulates Functional Connectivity of Sensory Motor Networks and Improves Reaching Accuracy in Chronic Stroke.

Neurorehabil Neural Repair 2019 Jan 29;33(1):70-81. Epub 2018 Dec 29.

1 McGill University, Montréal, QC, Canada.

Background: Passive robot-generated arm movements in conjunction with proprioceptive decision making and feedback modulate functional connectivity (FC) in sensory motor networks and improve sensorimotor adaptation in normal individuals. This proof-of-principle study investigates whether these effects can be observed in stroke patients.

Methods: A total of 10 chronic stroke patients with a range of stable motor and sensory deficits (Fugl-Meyer Arm score [FMA] 0-65, Nottingham Sensory Assessment [NSA] 10-40) underwent resting-state functional magnetic resonance imaging before and after a single session of robot-controlled proprioceptive training with feedback. Read More

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http://dx.doi.org/10.1177/1545968318818902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389407PMC
January 2019
1 Read

Response Heterogeneity With Exercise Training and Physical Activity Interventions Among Persons With Multiple Sclerosis.

Neurorehabil Neural Repair 2019 Jan 26;33(1):3-14. Epub 2018 Dec 26.

1 University of Alabama at Birmingham, Birmingham, AL, USA.

Multiple sclerosis (MS) is a heterogeneous disease, both in its pathology and symptomology. This poses a challenge for the medical management and rehabilitation of MS; however, physical activity and exercise training are rehabilitation approaches that have demonstrated beneficial effects on many of the burdensome consequences of MS such as mobility impairment and fatigue. Given the heterogeneous course of MS, it is possible that outcomes of physical activity and exercise training interventions demonstrate heterogeneity both in the magnitude and pattern of change, but there has been little focus on response heterogeneity with these interventions among persons with MS. Read More

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http://dx.doi.org/10.1177/1545968318818904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389390PMC
January 2019
8 Reads

Power Spectral Density Analysis of Long-Term Motor Recovery in Patients With Subacute Stroke.

Neurorehabil Neural Repair 2019 01 19;33(1):38-46. Epub 2018 Dec 19.

1 Kyungpook National University, Daegu, Korea.

Background: Prognostic measures of long-term motor recovery are important in patients with stroke presenting with severe hemiplegia.

Objective: We aimed to investigate whether initial power spectral density (PSD) analysis of resting-state functional magnetic resonance (fMRI) data can provide a sensitive prognostic predictor in patients with subacute stroke with severe hand disability.

Methods: Twelve patients with good recovery, 14 patients with poor recovery, and 12 healthy subjects were included. Read More

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http://dx.doi.org/10.1177/1545968318818900DOI Listing
January 2019
8 Reads

The Presence of a Paretic Propulsion Reserve During Gait in Individuals Following Stroke.

Neurorehabil Neural Repair 2018 12;32(12):1011-1019

1 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: The residual hemiparesis after stroke results in a unilateral reduction in propulsive force during gait. Prior work has suggested the presence of a propulsive reserve in the paretic limb.

Objective: The purpose of this study was to quantify the paretic propulsive reserve in individuals poststroke and to determine the biomechanical mechanism underlying the generation of additional paretic propulsive limb force. Read More

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http://dx.doi.org/10.1177/1545968318809920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300055PMC
December 2018
1 Read

Characterizing Spontaneous Motor Recovery Following Cortical and Subcortical Stroke in the Rat.

Neurorehabil Neural Repair 2019 Jan 10;33(1):27-37. Epub 2018 Dec 10.

1 University of Ottawa, Ottawa, Ontario, Canada.

Background: Stroke is a leading cause of neurological disability, often resulting in long-term motor impairments due to damage to cortical or subcortical motor areas. Despite the high prevalence of subcortical strokes in the clinical population, preclinical research has primarily focused on investigating and treating cortical strokes. Moreover, while both humans and animals show spontaneous recovery following stroke, little is known about how injury location affects this process. Read More

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http://dx.doi.org/10.1177/1545968318817823DOI Listing
January 2019

Cerebrolysin Reduces Astrogliosis and Axonal Injury and Enhances Neurogenesis in Rats After Closed Head Injury.

Neurorehabil Neural Repair 2019 Jan 30;33(1):15-26. Epub 2018 Nov 30.

1 Henry Ford Hospital, Detroit, MI, USA.

Background: Cerebrolysin is a neuropeptide preparation with neuroprotective and neurotrophic properties. Our previous study demonstrates that cerebrolysin significantly improves functional recovery in rats after mild traumatic brain injury (mTBI).

Objective: To determine histological outcomes associated with therapeutic effects of cerebrolysin on functional recovery after TBI. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318809916
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http://dx.doi.org/10.1177/1545968318809916DOI Listing
January 2019
3 Reads
3.976 Impact Factor

Neural Correlates of Hypokinetic Dysarthria and Mechanisms of Effective Voice Treatment in Parkinson Disease.

Neurorehabil Neural Repair 2018 12 16;32(12):1055-1066. Epub 2018 Nov 16.

2 University Hospital of Cologne, Germany.

Background: Hypokinetic dysarthria is highly prevalent in idiopathic Parkinson disease (PD), and effectiveness of high-intensity voice treatment is well established. However, the neural correlates remain largely unknown.

Objective: We aimed to specify cerebral pathophysiology of hypokinetic dysarthria and treatment-induced changes using functional magnetic resonance imaging (fMRI). Read More

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http://dx.doi.org/10.1177/1545968318812726DOI Listing
December 2018
23 Reads

Physiological Responses and Perceived Exertion During Robot-Assisted and Body Weight-Supported Gait After Stroke.

Neurorehabil Neural Repair 2018 12 12;32(12):1043-1054. Epub 2018 Nov 12.

1 Rehabilitation Research-Neurological Rehabilitation Group, Vrije Universiteit Brussel, Brussels, Belgium.

Introduction: Physiological responses are rarely considered during walking after stroke and if considered, only during a short period (3-6 minutes). The aims of this study were to examine physiological responses during 30-minute robot-assisted and body weight-supported treadmill and overground walking and compare intensities with exercise guidelines.

Methods: A total of 14 ambulatory stroke survivors (age: 61 ± 9 years; time after stroke: 2. Read More

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http://dx.doi.org/10.1177/1545968318810810DOI Listing
December 2018
33 Reads

Relationships Between Affected-Leg Motor Impairment, Postural Asymmetry, and Impaired Body Sway Control After Unilateral Supratentorial Stroke.

Neurorehabil Neural Repair 2018 11;32(11):953-960

1 Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: The relationships between motor impairment of the affected leg, postural control asymmetry, and impaired body sway control after stroke are not well understood.

Objective: To examine the relationship between motor impairment of the affected leg and reduced contribution of this leg to body sway control (ie, dynamic control asymmetry [DCA]) and to determine the relationships between impaired body sway control, DCA, and weight-bearing asymmetry (WBA).

Methods: We assessed quiet-standing balance with eyes open in 70 persons with a unilateral supratentorial chronic stroke using 2 force plates. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318804405
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http://dx.doi.org/10.1177/1545968318804405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238182PMC
November 2018
17 Reads

Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study.

Neurorehabil Neural Repair 2018 11;32(11):976-987

1 Institute of Neuroscience, Newcastle University Institute of Ageing, Newcastle upon Tyne, UK.

Background: Aging is associated with declining mobility, which negatively affects quality of life and incurs substantial economic costs. Techniques to maintain safe mobility in older adults are therefore essential. Rhythmic auditory cueing (RAC) can improve walking patterns in older adults. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318805159
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http://dx.doi.org/10.1177/1545968318805159DOI Listing
November 2018
16 Reads

Dopamine Replacement Medication Does Not Influence Implicit Learning of a Stepping Task in People With Parkinson's Disease.

Neurorehabil Neural Repair 2018 12 9;32(12):1031-1042. Epub 2018 Nov 9.

2 University of Utah, Salt Lake City, UT, USA.

Introduction: Treatment of Parkinson's disease (PD) with exogenous dopamine (ie, levodopa) may positively affect motor symptoms, but may negatively affect other functions such as the learning of motor skills necessary for rehabilitation. This study aimed to determine whether levodopa medication affects general and sequence-specific learning of a stepping task and the transfer of movement skill to untrained balance tasks in people with PD.

Methods: Participants with PD were randomized to practice "on" (n = 14) or "off" (n = 13) levodopa medication. Read More

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http://dx.doi.org/10.1177/1545968318809922DOI Listing
December 2018
13 Reads

Different Error Size During Locomotor Adaptation Affects Transfer to Overground Walking Poststroke.

Neurorehabil Neural Repair 2018 12 9;32(12):1020-1030. Epub 2018 Nov 9.

1 University of Delaware, Newark, DE, USA.

Background: Studies in neurologically intact subjects suggest that the gradual presentation of small perturbations (errors) during learning results in better transfer of a newly learned walking pattern to overground walking. Whether the same result would be true after stroke is not known.

Objective: To determine whether introducing gradual perturbations, during locomotor learning using a split-belt treadmill influences learning the novel walking pattern or transfer to overground walking poststroke. Read More

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http://dx.doi.org/10.1177/1545968318809921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298810PMC
December 2018
6 Reads

Subcortical Brain Involvement Is Associated With Impaired Performance on the Psychomotor Vigilance Task After Minor Stroke.

Neurorehabil Neural Repair 2018 11 24;32(11):999-1007. Epub 2018 Oct 24.

1 Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Objective: Impaired attentional processes have been linked with poor outcomes after stroke, but their radiographical correlates have been infrequently studied. Our objective was to assess the relationship between stroke location and vigilant attention.

Methods: A total of 39 patients presenting within 2 weeks of a minor stroke were prospectively recruited. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318804415
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http://dx.doi.org/10.1177/1545968318804415DOI Listing
November 2018
15 Reads

Noninvasive Brain Stimulation to Enhance Functional Recovery After Stroke: Studies in Animal Models.

Neurorehabil Neural Repair 2018 11 24;32(11):927-940. Epub 2018 Oct 24.

1 Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.

Background: Stroke is the leading cause of adult disability, but treatment options remain limited, leaving most patients with incomplete recovery. Patient and animal studies have shown potential of noninvasive brain stimulation (NIBS) strategies to improve function after stroke. However, mechanisms underlying therapeutic effects of NIBS are unclear and there is no consensus on which NIBS protocols are most effective. Read More

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http://dx.doi.org/10.1177/1545968318804425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238175PMC
November 2018
10 Reads

Adaptive Cueing Treatment of Neglect in Stroke Patients Leads to Improvements in Activities of Daily Living: A Randomized Controlled, Crossover Trial.

Neurorehabil Neural Repair 2018 11 17;32(11):988-998. Epub 2018 Oct 17.

1 Klinikum Bremen-Ost, Bremen, Germany.

Background: Visuospatial neglect is a disabling syndrome with serious consequences for activities in daily life. This study investigated the effect of adaptive cueing during a reading task as a possible treatment for neglect by including (1) a task relevant for the patient's daily life, (2) a fading out procedure to stimulate independent orientation to the left by self-cueing, and (3) a clear definition of neglect severity for the adaptive treatment protocol.

Methods: A randomized controlled crossover design was used, including 26 patients from an early rehabilitation unit with left-sided visuospatial neglect after stroke or hemorrhage. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318807054
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http://dx.doi.org/10.1177/1545968318807054DOI Listing
November 2018
3 Reads

The Body Position Spatial Task, a Test of Whole-Body Spatial Cognition: Comparison Between Adults With and Without Parkinson Disease.

Neurorehabil Neural Repair 2018 11 15;32(11):961-975. Epub 2018 Oct 15.

2 Atlanta Veterans Affairs Medical Center, Decatur, GA, USA.

Background: The Body Position Spatial Task (BPST) is a novel measure of whole-body spatial cognition involving multidirectional steps and turns. Individuals with Parkinson disease (PD) are affected by motor and cognitive impairments, particularly in spatial function, which is important for mental imagery and navigation. Performance on the BPST may inform understanding of motor-cognitive and spatial cognitive function of individuals with PD. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318804419
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http://dx.doi.org/10.1177/1545968318804419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226349PMC
November 2018
2 Reads

Intervention-Induced Motor Cortex Plasticity in Hemiparetic Children With Perinatal Stroke.

Neurorehabil Neural Repair 2018 11 4;32(11):941-952. Epub 2018 Oct 4.

1 Alberta Children's Hospital, Calgary, Alberta, Canada.

Background: Clinical trials are suggesting efficacy of intensive therapy combined with brain stimulation to improve hand function in hemiparetic children with perinatal stroke. However, individual variability exists and the underlying neuroplasticity mechanisms are unknown. Exploring primary motor cortex (M1) neurophysiology, and how it changes with such interventions, may provide valuable biomarkers for advancing personalized neurorehabilitation. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318801546
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http://dx.doi.org/10.1177/1545968318801546DOI Listing
November 2018
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Effects of Prefrontal Transcranial Direct Current Stimulation on Lexical Access in Chronic Poststroke Aphasia.

Neurorehabil Neural Repair 2018 10 1;32(10):913-923. Epub 2018 Oct 1.

1 University of Fribourg, Switzerland.

Background: A successful interplay between prefrontal and domain-specific language areas is critical for language processing. Previous studies involving people with aphasia have shown that executive control processes might act on lexical-semantic representations during retrieval. Modulating the prefrontal control network by means of noninvasive brain stimulation might, therefore, improve lexical access in people with aphasia. Read More

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http://dx.doi.org/10.1177/1545968318801551DOI Listing
October 2018
16 Reads

Exercise Guidelines for Gait Function in Parkinson's Disease: A Systematic Review and Meta-analysis.

Neurorehabil Neural Repair 2018 10 28;32(10):872-886. Epub 2018 Sep 28.

3 University of Miami, FL, USA.

This systematic review and meta-analysis is to provide comprehensive evidence-based exercise recommendations targeting walking function for adults with Parkinson's disease.

Methods: Fixed- or random-effect meta-analyses estimated standardized effect sizes (Hedge's g), comparing treatment effects from exercise with nonexercise and another form of exercise (non-EXE control and EXE control). Cuing and exercise duration were used as moderators for subanalyses. Read More

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http://dx.doi.org/10.1177/1545968318801558DOI Listing
October 2018
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Electrical Somatosensory Stimulation in Early Rehabilitation of Arm Paresis After Stroke: A Randomized Controlled Trial.

Neurorehabil Neural Repair 2018 10 25;32(10):899-912. Epub 2018 Sep 25.

1 Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Background: Arm paresis is present in 48% to 77% of acute stroke patients. Complete functional recovery is reported in only 12% to 34%. Although the arm recovery is most pronounced during the first 4 weeks poststroke, few studies examined the effect of upper extremity interventions during this period. Read More

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http://dx.doi.org/10.1177/1545968318799496DOI Listing
October 2018
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Children With Cerebral Palsy Have Greater Stride-to-Stride Variability of Muscle Synergies During Gait Than Typically Developing Children: Implications for Motor Control Complexity.

Neurorehabil Neural Repair 2018 09;32(9):834-844

1 National Institutes of Health, Bethesda, MD, USA.

Background: There is mounting evidence that the central nervous system utilizes a modular approach for neuromuscular control of walking by activating groups of muscles in units termed muscle synergies. Examination of muscle synergies in clinical populations may provide insights into alteration of neuromuscular control underlying pathological gait patterns. Previous studies utilizing synergy analysis have reported reduced motor control complexity during walking in those with neurological deficits, revealing the potential clinical utility of this approach. Read More

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http://dx.doi.org/10.1177/1545968318796333DOI Listing
September 2018
2 Reads

Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration.

Neurorehabil Neural Repair 2018 09;32(9):765-776

2 University of Maryland School of Medicine, Baltimore, MD, USA.

Peripheral nerve injury is a major clinical problem and often results in a poor functional recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal. In the nervous system, exosomes, which are nanosized extracellular vesicles, play a critical role in mediating intercellular communication. Read More

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http://dx.doi.org/10.1177/1545968318798955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146407PMC
September 2018
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Integrative CNS Plasticity With Exercise in MS: The PRIMERS (PRocessing, Integration of Multisensory Exercise-Related Stimuli) Conceptual Framework.

Neurorehabil Neural Repair 2018 10 12;32(10):847-862. Epub 2018 Sep 12.

4 Kessler Foundation, West Orange, NJ, USA.

There is a proliferation of research examining the effects of exercise on mobility and cognition in the general population and those with neurological disorders as well as focal research examining possible neural mechanisms of such effects. However, there is seemingly a lack of focus on what it is about exercise, in particular, that drives adaptive central nervous system neuroplasticity. We propose a novel conceptual framework (ie, PRIMERS) that describes such adaptations as occurring via activity-dependent neuroplasticity based on the integrative processing of multisensory input and associated complex motor output that is required for the regulation of physiological systems during exercise behavior. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318798938
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http://dx.doi.org/10.1177/1545968318798938DOI Listing
October 2018
13 Reads

Relating Anticipatory Postural Adjustments to Step Outcomes During Loss of Balance in People With Parkinson's Disease.

Neurorehabil Neural Repair 2018 10 10;32(10):887-898. Epub 2018 Sep 10.

4 Oregon Health & Science University, Portland, OR, USA.

Background: Effective protective steps are critical for fall prevention, and anticipatory postural adjustments (APAs) after a perturbation but prior to protective steps affect step performance. Although APAs prior to protective steps are altered in people with Parkinson's disease (PD), whether these changes affect subsequent step performance is poorly understood.

Objective: Characterize the relationship between mediolateral APA size and protective step outcomes in response to anteroposterior balance perturbations in people with PD. Read More

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http://dx.doi.org/10.1177/1545968318798937DOI Listing
October 2018
2 Reads