1,296 results match your criteria Neurorehabilitation and Neural Repair[Journal]


Is Unilateral Spatial Neglect Associated With Motor Recovery of the Affected Upper Extremity Poststroke? A Systematic Review.

Neurorehabil Neural Repair 2019 Feb 20:1545968319832606. Epub 2019 Feb 20.

2 School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Background And Purpose: Individuals with stroke often present symptoms of multiple domains, such as weakness of the affected upper extremity (UE) and unilateral spatial neglect (USN), which are both associated with poor functional outcome. The aims of this systematic review were to search and review studies that investigated (1) the relationship between USN and affected UE sensorimotor recovery poststroke and (2) the effectiveness of sensorimotor interventions to improve the affected UE in patients with USN.

Methods: An electronic search of databases (MEDLINE, EMBASE, CINAHL and Cochrane CENTRAL) was conducted using a combination of the following terms: stroke, USN, and affected UE. Read More

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http://dx.doi.org/10.1177/1545968319832606DOI Listing
February 2019

Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection.

Neurorehabil Neural Repair 2019 Feb 19:1545968319829456. Epub 2019 Feb 19.

1 University of California, Los Angeles, CA, USA.

Background: We previously demonstrated that step training leads to reorganization of neuronal networks in the lumbar spinal cord of rodents after a hemisection (HX) injury and step training, including increases excitability of spinally evoked potentials in hindlimb motor neurons.

Methods: In this study, we investigated changes in RNA expression and synapse number using RNA-Seq and immunohistochemistry of the lumbar spinal cord 23 days after a mid-thoracic HX in rats with and without post-HX step training.

Results: Gene Ontology (GO) term clustering demonstrated that expression levels of 36 synapse-related genes were increased in trained compared with nontrained rats. Read More

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http://dx.doi.org/10.1177/1545968319829456DOI Listing
February 2019

Effects of Perturbation-Based Balance Training in Subacute Persons With Stroke: A Randomized Controlled Trial.

Neurorehabil Neural Repair 2019 Feb 15:1545968319829453. Epub 2019 Feb 15.

1 Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel.

Background: Reactive balance responses are critical for fall prevention. Perturbation-based balance training (PBBT) has shown a positive effect in reducing the risk of falls among older adults and persons with Parkinson's disease.

Objective: To explore the effect of a short-term PBBT on reactive balance responses, performance-based measures of balance and gait and balance confidence. Read More

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http://dx.doi.org/10.1177/1545968319829453DOI Listing
February 2019

Language as a Predictor of Motor Recovery: The Case for a More Global Approach to Stroke Rehabilitation.

Neurorehabil Neural Repair 2019 Feb 13:1545968319829454. Epub 2019 Feb 13.

3 Curtin University, Perth, Western Australia, Australia.

Stroke is the third leading cause of death in the developed world and the primary cause of adult disability. The most common site of stroke is the middle cerebral artery (MCA), an artery that supplies a range of areas involved in both language and motor function. As a consequence, many stroke patients experience a combination of language and motor deficits. Read More

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http://dx.doi.org/10.1177/1545968319829454DOI Listing
February 2019
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Using Vision to Study Poststroke Recovery and Test Hypotheses About Neurorehabilitation.

Neurorehabil Neural Repair 2019 Feb;33(2):87-95

1 University of Rochester, Rochester, NY, USA.

Approximately one-third of stroke patients suffer visual field impairment as a result of their strokes. However, studies using the visual pathway as a paradigm for studying poststroke recovery are limited. In this article, we propose that the visual pathway has many features that make it an excellent model system for studying poststroke neuroplasticity and assessing the efficacy of therapeutic interventions. Read More

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http://dx.doi.org/10.1177/1545968319827569DOI Listing
February 2019

Aerobic Exercise Therapy in Ambulatory Patients With ALS: A Randomized Controlled Trial.

Neurorehabil Neural Repair 2019 Feb;33(2):153-164

1 University Medical Center Utrecht, Netherlands.

Background: Weakness caused by motor neuron degeneration in amyotrophic lateral sclerosis (ALS) may result in avoidance of physical activity, resulting in deconditioning and reduced health-related quality of life (HRQoL).

Objective: To study the effectiveness of aerobic exercise therapy (AET) on disease-specific and generic HRQoL in ambulatory patients with ALS.

Methods: We conducted a multicenter, assessor-blinded, randomized controlled trial. Read More

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http://journals.sagepub.com/doi/10.1177/1545968319826051
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http://dx.doi.org/10.1177/1545968319826051DOI Listing
February 2019
2 Reads

Relationship Between Spasticity and Upper-Limb Movement Disorders in Individuals With Subacute Stroke Using Stochastic Spatiotemporal Modeling.

Neurorehabil Neural Repair 2019 Feb;33(2):141-152

1 Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Spasticity is common in patients with stroke, yet current quantification methods are insufficient for determining the relationship between spasticity and voluntary movement deficits. This is partly a result of the effects of spasticity on spatiotemporal characteristics of movement and the variability of voluntary movement. These can be captured by Gaussian mixture models (GMMs). Read More

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http://dx.doi.org/10.1177/1545968319826050DOI Listing
February 2019
1 Read

The Influence of Primary Motor Cortex Inhibition on Upper Limb Impairment and Function in Chronic Stroke: A Multimodal Study.

Neurorehabil Neural Repair 2019 Feb;33(2):130-140

1 The University of Auckland, Auckland, New Zealand.

Background: Stroke is a leading cause of adult disability owing largely to motor impairment and loss of function. After stroke, there may be abnormalities in γ-aminobutyric acid (GABA)-mediated inhibitory function within primary motor cortex (M1), which may have implications for residual motor impairment and the potential for functional improvements at the chronic stage.

Objective: To quantify GABA neurotransmission and concentration within ipsilesional and contralesional M1 and determine if they relate to upper limb impairment and function at the chronic stage of stroke. Read More

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http://dx.doi.org/10.1177/1545968319826052DOI Listing
February 2019

Brain-Machine Interface in Chronic Stroke: Randomized Trial Long-Term Follow-up.

Neurorehabil Neural Repair 2019 Feb 5:1545968319827573. Epub 2019 Feb 5.

1 University of Tubingen, Tübingen, Germany.

Background: Brain-machine interfaces (BMIs) have been recently proposed as a new tool to induce functional recovery in stroke patients.

Objective: Here we evaluated long-term effects of BMI training and physiotherapy in motor function of severely paralyzed chronic stroke patients 6 months after intervention.

Methods: A total of 30 chronic stroke patients with severe hand paresis from our previous study were invited, and 28 underwent follow-up assessments. Read More

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http://dx.doi.org/10.1177/1545968319827573DOI Listing
February 2019
3 Reads

Electromyogram-Related Neuromuscular Electrical Stimulation for Restoring Wrist and Hand Movement in Poststroke Hemiplegia: A Systematic Review and Meta-Analysis.

Neurorehabil Neural Repair 2019 Feb 1;33(2):96-111. Epub 2019 Feb 1.

2 Jewish Rehabilitation Hospital Site, Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), Laval, Canada.

Background: Clinical trials have demonstrated some benefits of electromyogram-triggered/controlled neuromuscular electrical stimulation (EMG-NMES) on motor recovery of upper limb (UL) function in patients with stroke. However, EMG-NMES use in clinical practice is limited due to a lack of evidence supporting its effectiveness.

Objective: To perform a systematic review and meta-analysis to determine the effects of EMG-NMES on stroke UL recovery based on each of the International Classification of Functioning, Disability, and Health (ICF) domains. Read More

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http://dx.doi.org/10.1177/1545968319826053DOI Listing
February 2019
1 Read

Effect of Specific Over Nonspecific VR-Based Rehabilitation on Poststroke Motor Recovery: A Systematic Meta-analysis.

Neurorehabil Neural Repair 2019 Feb 30;33(2):112-129. Epub 2019 Jan 30.

1 Laboratory of Synthetic, Perceptive, Emotive and Cognitive Systems (SPECS), Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Background: Despite the rise of virtual reality (VR)-based interventions in stroke rehabilitation over the past decade, no consensus has been reached on its efficacy. This ostensibly puzzling outcome might not be that surprising given that VR is intrinsically neutral to its use-that is, an intervention is effective because of its ability to mobilize recovery mechanisms, not its technology. As VR systems specifically built for rehabilitation might capitalize better on the advantages of technology to implement neuroscientifically grounded protocols, they might be more effective than those designed for recreational gaming. Read More

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http://dx.doi.org/10.1177/1545968318820169DOI Listing
February 2019

Compensation or Recovery? Altered Kinetics and Neuromuscular Synergies Following High-Intensity Stepping Training Poststroke.

Neurorehabil Neural Repair 2018 Dec 29:1545968318817825. Epub 2018 Dec 29.

1 Indiana University, Indianapolis, IN, USA.

Background: High-intensity, variable stepping training can improve walking speed in individuals poststroke, although neuromuscular strategies used to achieve faster speeds are unclear. We evaluated changes in joint kinetics and neuromuscular coordination following such training; movement strategies consistent with intact individuals were considered evidence of recovery and abnormal strategies indicative of compensation.

Methods: A total of 15 individuals with stroke (duration: 23 ± 30 months) received ≤40 sessions of high-intensity stepping in variable contexts (tasks and environments). Read More

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http://dx.doi.org/10.1177/1545968318817825DOI Listing
December 2018

Full Activation Profiles and Integrity of Corticospinal Pathways in Adults With Bilateral Spastic Cerebral Palsy.

Neurorehabil Neural Repair 2018 Dec 29:1545968318818898. Epub 2018 Dec 29.

2 University of Alberta, Edmonton, Alberta, Canada.

Background: Dysfunction of corticospinal pathways has been implicated in motor impairments in people with bilateral spastic cerebral palsy (CP). While structural damage to corticospinal pathways in people with CP is known, its impact on the activation of these pathways is not.

Objective: To provide the first, complete activation profile of corticospinal pathways in adults with CP using a full range of transcranial magnetic stimulation (TMS) intensities and voluntary contractions. Read More

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http://dx.doi.org/10.1177/1545968318818898DOI Listing
December 2018
3 Reads

A Single Session of Robot-Controlled Proprioceptive Training Modulates Functional Connectivity of Sensory Motor Networks and Improves Reaching Accuracy in Chronic Stroke.

Neurorehabil Neural Repair 2018 Dec 29:1545968318818902. Epub 2018 Dec 29.

1 McGill University, Montréal, QC, Canada.

Background: Passive robot-generated arm movements in conjunction with proprioceptive decision making and feedback modulate functional connectivity (FC) in sensory motor networks and improve sensorimotor adaptation in normal individuals. This proof-of-principle study investigates whether these effects can be observed in stroke patients.

Methods: A total of 10 chronic stroke patients with a range of stable motor and sensory deficits (Fugl-Meyer Arm score [FMA] 0-65, Nottingham Sensory Assessment [NSA] 10-40) underwent resting-state functional magnetic resonance imaging before and after a single session of robot-controlled proprioceptive training with feedback. Read More

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http://dx.doi.org/10.1177/1545968318818902DOI Listing
December 2018

Response Heterogeneity With Exercise Training and Physical Activity Interventions Among Persons With Multiple Sclerosis.

Neurorehabil Neural Repair 2018 Dec 26:1545968318818904. Epub 2018 Dec 26.

1 University of Alabama at Birmingham, Birmingham, AL, USA.

Multiple sclerosis (MS) is a heterogeneous disease, both in its pathology and symptomology. This poses a challenge for the medical management and rehabilitation of MS; however, physical activity and exercise training are rehabilitation approaches that have demonstrated beneficial effects on many of the burdensome consequences of MS such as mobility impairment and fatigue. Given the heterogeneous course of MS, it is possible that outcomes of physical activity and exercise training interventions demonstrate heterogeneity both in the magnitude and pattern of change, but there has been little focus on response heterogeneity with these interventions among persons with MS. Read More

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http://dx.doi.org/10.1177/1545968318818904DOI Listing
December 2018
6 Reads

Power Spectral Density Analysis of Long-Term Motor Recovery in Patients With Subacute Stroke.

Neurorehabil Neural Repair 2019 01 19;33(1):38-46. Epub 2018 Dec 19.

1 Kyungpook National University, Daegu, Korea.

Background: Prognostic measures of long-term motor recovery are important in patients with stroke presenting with severe hemiplegia.

Objective: We aimed to investigate whether initial power spectral density (PSD) analysis of resting-state functional magnetic resonance (fMRI) data can provide a sensitive prognostic predictor in patients with subacute stroke with severe hand disability.

Methods: Twelve patients with good recovery, 14 patients with poor recovery, and 12 healthy subjects were included. Read More

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http://dx.doi.org/10.1177/1545968318818900DOI Listing
January 2019
3 Reads

The Presence of a Paretic Propulsion Reserve During Gait in Individuals Following Stroke.

Neurorehabil Neural Repair 2018 12;32(12):1011-1019

1 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: The residual hemiparesis after stroke results in a unilateral reduction in propulsive force during gait. Prior work has suggested the presence of a propulsive reserve in the paretic limb.

Objective: The purpose of this study was to quantify the paretic propulsive reserve in individuals poststroke and to determine the biomechanical mechanism underlying the generation of additional paretic propulsive limb force. Read More

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http://dx.doi.org/10.1177/1545968318809920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300055PMC
December 2018
1 Read

Characterizing Spontaneous Motor Recovery Following Cortical and Subcortical Stroke in the Rat.

Neurorehabil Neural Repair 2018 Dec 10:1545968318817823. Epub 2018 Dec 10.

1 University of Ottawa, Ottawa, Ontario, Canada.

Background: Stroke is a leading cause of neurological disability, often resulting in long-term motor impairments due to damage to cortical or subcortical motor areas. Despite the high prevalence of subcortical strokes in the clinical population, preclinical research has primarily focused on investigating and treating cortical strokes. Moreover, while both humans and animals show spontaneous recovery following stroke, little is known about how injury location affects this process. Read More

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http://dx.doi.org/10.1177/1545968318817823DOI Listing
December 2018

Cerebrolysin Reduces Astrogliosis and Axonal Injury and Enhances Neurogenesis in Rats After Closed Head Injury.

Neurorehabil Neural Repair 2018 Nov 30:1545968318809916. Epub 2018 Nov 30.

1 Henry Ford Hospital, Detroit, MI, USA.

Background: Cerebrolysin is a neuropeptide preparation with neuroprotective and neurotrophic properties. Our previous study demonstrates that cerebrolysin significantly improves functional recovery in rats after mild traumatic brain injury (mTBI).

Objective: To determine histological outcomes associated with therapeutic effects of cerebrolysin on functional recovery after TBI. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318809916
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http://dx.doi.org/10.1177/1545968318809916DOI Listing
November 2018
3 Reads
3.976 Impact Factor

Neural Correlates of Hypokinetic Dysarthria and Mechanisms of Effective Voice Treatment in Parkinson Disease.

Neurorehabil Neural Repair 2018 12 16;32(12):1055-1066. Epub 2018 Nov 16.

2 University Hospital of Cologne, Germany.

Background: Hypokinetic dysarthria is highly prevalent in idiopathic Parkinson disease (PD), and effectiveness of high-intensity voice treatment is well established. However, the neural correlates remain largely unknown.

Objective: We aimed to specify cerebral pathophysiology of hypokinetic dysarthria and treatment-induced changes using functional magnetic resonance imaging (fMRI). Read More

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http://dx.doi.org/10.1177/1545968318812726DOI Listing
December 2018
18 Reads

Physiological Responses and Perceived Exertion During Robot-Assisted and Body Weight-Supported Gait After Stroke.

Neurorehabil Neural Repair 2018 12 12;32(12):1043-1054. Epub 2018 Nov 12.

1 Rehabilitation Research-Neurological Rehabilitation Group, Vrije Universiteit Brussel, Brussels, Belgium.

Introduction: Physiological responses are rarely considered during walking after stroke and if considered, only during a short period (3-6 minutes). The aims of this study were to examine physiological responses during 30-minute robot-assisted and body weight-supported treadmill and overground walking and compare intensities with exercise guidelines.

Methods: A total of 14 ambulatory stroke survivors (age: 61 ± 9 years; time after stroke: 2. Read More

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http://dx.doi.org/10.1177/1545968318810810DOI Listing
December 2018
20 Reads

Relationships Between Affected-Leg Motor Impairment, Postural Asymmetry, and Impaired Body Sway Control After Unilateral Supratentorial Stroke.

Neurorehabil Neural Repair 2018 11;32(11):953-960

1 Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: The relationships between motor impairment of the affected leg, postural control asymmetry, and impaired body sway control after stroke are not well understood.

Objective: To examine the relationship between motor impairment of the affected leg and reduced contribution of this leg to body sway control (ie, dynamic control asymmetry [DCA]) and to determine the relationships between impaired body sway control, DCA, and weight-bearing asymmetry (WBA).

Methods: We assessed quiet-standing balance with eyes open in 70 persons with a unilateral supratentorial chronic stroke using 2 force plates. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318804405
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http://dx.doi.org/10.1177/1545968318804405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238182PMC
November 2018
13 Reads

Reduced Gait Variability and Enhanced Brain Activity in Older Adults With Auditory Cues: A Functional Near-Infrared Spectroscopy Study.

Neurorehabil Neural Repair 2018 11;32(11):976-987

1 Institute of Neuroscience, Newcastle University Institute of Ageing, Newcastle upon Tyne, UK.

Background: Aging is associated with declining mobility, which negatively affects quality of life and incurs substantial economic costs. Techniques to maintain safe mobility in older adults are therefore essential. Rhythmic auditory cueing (RAC) can improve walking patterns in older adults. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318805159
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http://dx.doi.org/10.1177/1545968318805159DOI Listing
November 2018
11 Reads

Dopamine Replacement Medication Does Not Influence Implicit Learning of a Stepping Task in People With Parkinson's Disease.

Neurorehabil Neural Repair 2018 12 9;32(12):1031-1042. Epub 2018 Nov 9.

2 University of Utah, Salt Lake City, UT, USA.

Introduction: Treatment of Parkinson's disease (PD) with exogenous dopamine (ie, levodopa) may positively affect motor symptoms, but may negatively affect other functions such as the learning of motor skills necessary for rehabilitation. This study aimed to determine whether levodopa medication affects general and sequence-specific learning of a stepping task and the transfer of movement skill to untrained balance tasks in people with PD.

Methods: Participants with PD were randomized to practice "on" (n = 14) or "off" (n = 13) levodopa medication. Read More

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http://dx.doi.org/10.1177/1545968318809922DOI Listing
December 2018
8 Reads

Different Error Size During Locomotor Adaptation Affects Transfer to Overground Walking Poststroke.

Neurorehabil Neural Repair 2018 12 9;32(12):1020-1030. Epub 2018 Nov 9.

1 University of Delaware, Newark, DE, USA.

Background: Studies in neurologically intact subjects suggest that the gradual presentation of small perturbations (errors) during learning results in better transfer of a newly learned walking pattern to overground walking. Whether the same result would be true after stroke is not known.

Objective: To determine whether introducing gradual perturbations, during locomotor learning using a split-belt treadmill influences learning the novel walking pattern or transfer to overground walking poststroke. Read More

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http://dx.doi.org/10.1177/1545968318809921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298810PMC
December 2018
6 Reads

Subcortical Brain Involvement Is Associated With Impaired Performance on the Psychomotor Vigilance Task After Minor Stroke.

Neurorehabil Neural Repair 2018 11 24;32(11):999-1007. Epub 2018 Oct 24.

1 Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Objective: Impaired attentional processes have been linked with poor outcomes after stroke, but their radiographical correlates have been infrequently studied. Our objective was to assess the relationship between stroke location and vigilant attention.

Methods: A total of 39 patients presenting within 2 weeks of a minor stroke were prospectively recruited. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318804415
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http://dx.doi.org/10.1177/1545968318804415DOI Listing
November 2018
9 Reads

Noninvasive Brain Stimulation to Enhance Functional Recovery After Stroke: Studies in Animal Models.

Neurorehabil Neural Repair 2018 11 24;32(11):927-940. Epub 2018 Oct 24.

1 Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.

Background: Stroke is the leading cause of adult disability, but treatment options remain limited, leaving most patients with incomplete recovery. Patient and animal studies have shown potential of noninvasive brain stimulation (NIBS) strategies to improve function after stroke. However, mechanisms underlying therapeutic effects of NIBS are unclear and there is no consensus on which NIBS protocols are most effective. Read More

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http://dx.doi.org/10.1177/1545968318804425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238175PMC
November 2018
6 Reads

Adaptive Cueing Treatment of Neglect in Stroke Patients Leads to Improvements in Activities of Daily Living: A Randomized Controlled, Crossover Trial.

Neurorehabil Neural Repair 2018 11 17;32(11):988-998. Epub 2018 Oct 17.

1 Klinikum Bremen-Ost, Bremen, Germany.

Background: Visuospatial neglect is a disabling syndrome with serious consequences for activities in daily life. This study investigated the effect of adaptive cueing during a reading task as a possible treatment for neglect by including (1) a task relevant for the patient's daily life, (2) a fading out procedure to stimulate independent orientation to the left by self-cueing, and (3) a clear definition of neglect severity for the adaptive treatment protocol.

Methods: A randomized controlled crossover design was used, including 26 patients from an early rehabilitation unit with left-sided visuospatial neglect after stroke or hemorrhage. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318807054
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http://dx.doi.org/10.1177/1545968318807054DOI Listing
November 2018
2 Reads

The Body Position Spatial Task, a Test of Whole-Body Spatial Cognition: Comparison Between Adults With and Without Parkinson Disease.

Neurorehabil Neural Repair 2018 11 15;32(11):961-975. Epub 2018 Oct 15.

2 Atlanta Veterans Affairs Medical Center, Decatur, GA, USA.

Background: The Body Position Spatial Task (BPST) is a novel measure of whole-body spatial cognition involving multidirectional steps and turns. Individuals with Parkinson disease (PD) are affected by motor and cognitive impairments, particularly in spatial function, which is important for mental imagery and navigation. Performance on the BPST may inform understanding of motor-cognitive and spatial cognitive function of individuals with PD. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318804419
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http://dx.doi.org/10.1177/1545968318804419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226349PMC
November 2018
1 Read

Intervention-Induced Motor Cortex Plasticity in Hemiparetic Children With Perinatal Stroke.

Neurorehabil Neural Repair 2018 11 4;32(11):941-952. Epub 2018 Oct 4.

1 Alberta Children's Hospital, Calgary, Alberta, Canada.

Background: Clinical trials are suggesting efficacy of intensive therapy combined with brain stimulation to improve hand function in hemiparetic children with perinatal stroke. However, individual variability exists and the underlying neuroplasticity mechanisms are unknown. Exploring primary motor cortex (M1) neurophysiology, and how it changes with such interventions, may provide valuable biomarkers for advancing personalized neurorehabilitation. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318801546
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http://dx.doi.org/10.1177/1545968318801546DOI Listing
November 2018
2 Reads

Effects of Prefrontal Transcranial Direct Current Stimulation on Lexical Access in Chronic Poststroke Aphasia.

Neurorehabil Neural Repair 2018 10 1;32(10):913-923. Epub 2018 Oct 1.

1 University of Fribourg, Switzerland.

Background: A successful interplay between prefrontal and domain-specific language areas is critical for language processing. Previous studies involving people with aphasia have shown that executive control processes might act on lexical-semantic representations during retrieval. Modulating the prefrontal control network by means of noninvasive brain stimulation might, therefore, improve lexical access in people with aphasia. Read More

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http://dx.doi.org/10.1177/1545968318801551DOI Listing
October 2018
7 Reads

Exercise Guidelines for Gait Function in Parkinson's Disease: A Systematic Review and Meta-analysis.

Neurorehabil Neural Repair 2018 10 28;32(10):872-886. Epub 2018 Sep 28.

3 University of Miami, FL, USA.

This systematic review and meta-analysis is to provide comprehensive evidence-based exercise recommendations targeting walking function for adults with Parkinson's disease.

Methods: Fixed- or random-effect meta-analyses estimated standardized effect sizes (Hedge's g), comparing treatment effects from exercise with nonexercise and another form of exercise (non-EXE control and EXE control). Cuing and exercise duration were used as moderators for subanalyses. Read More

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http://dx.doi.org/10.1177/1545968318801558DOI Listing
October 2018
3 Reads

Electrical Somatosensory Stimulation in Early Rehabilitation of Arm Paresis After Stroke: A Randomized Controlled Trial.

Neurorehabil Neural Repair 2018 10 25;32(10):899-912. Epub 2018 Sep 25.

1 Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Background: Arm paresis is present in 48% to 77% of acute stroke patients. Complete functional recovery is reported in only 12% to 34%. Although the arm recovery is most pronounced during the first 4 weeks poststroke, few studies examined the effect of upper extremity interventions during this period. Read More

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http://dx.doi.org/10.1177/1545968318799496DOI Listing
October 2018
6 Reads

Children With Cerebral Palsy Have Greater Stride-to-Stride Variability of Muscle Synergies During Gait Than Typically Developing Children: Implications for Motor Control Complexity.

Neurorehabil Neural Repair 2018 09;32(9):834-844

1 National Institutes of Health, Bethesda, MD, USA.

Background: There is mounting evidence that the central nervous system utilizes a modular approach for neuromuscular control of walking by activating groups of muscles in units termed muscle synergies. Examination of muscle synergies in clinical populations may provide insights into alteration of neuromuscular control underlying pathological gait patterns. Previous studies utilizing synergy analysis have reported reduced motor control complexity during walking in those with neurological deficits, revealing the potential clinical utility of this approach. Read More

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http://dx.doi.org/10.1177/1545968318796333DOI Listing
September 2018
2 Reads

Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration.

Neurorehabil Neural Repair 2018 09;32(9):765-776

2 University of Maryland School of Medicine, Baltimore, MD, USA.

Peripheral nerve injury is a major clinical problem and often results in a poor functional recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal. In the nervous system, exosomes, which are nanosized extracellular vesicles, play a critical role in mediating intercellular communication. Read More

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http://dx.doi.org/10.1177/1545968318798955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146407PMC
September 2018
1 Read

Integrative CNS Plasticity With Exercise in MS: The PRIMERS (PRocessing, Integration of Multisensory Exercise-Related Stimuli) Conceptual Framework.

Neurorehabil Neural Repair 2018 10 12;32(10):847-862. Epub 2018 Sep 12.

4 Kessler Foundation, West Orange, NJ, USA.

There is a proliferation of research examining the effects of exercise on mobility and cognition in the general population and those with neurological disorders as well as focal research examining possible neural mechanisms of such effects. However, there is seemingly a lack of focus on what it is about exercise, in particular, that drives adaptive central nervous system neuroplasticity. We propose a novel conceptual framework (ie, PRIMERS) that describes such adaptations as occurring via activity-dependent neuroplasticity based on the integrative processing of multisensory input and associated complex motor output that is required for the regulation of physiological systems during exercise behavior. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318798938
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http://dx.doi.org/10.1177/1545968318798938DOI Listing
October 2018
6 Reads

Relating Anticipatory Postural Adjustments to Step Outcomes During Loss of Balance in People With Parkinson's Disease.

Neurorehabil Neural Repair 2018 10 10;32(10):887-898. Epub 2018 Sep 10.

4 Oregon Health & Science University, Portland, OR, USA.

Background: Effective protective steps are critical for fall prevention, and anticipatory postural adjustments (APAs) after a perturbation but prior to protective steps affect step performance. Although APAs prior to protective steps are altered in people with Parkinson's disease (PD), whether these changes affect subsequent step performance is poorly understood.

Objective: Characterize the relationship between mediolateral APA size and protective step outcomes in response to anteroposterior balance perturbations in people with PD. Read More

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http://dx.doi.org/10.1177/1545968318798937DOI Listing
October 2018
2 Reads

Repetitive Peripheral Sensory Stimulation and Upper Limb Performance in Stroke: A Systematic Review and Meta-analysis.

Neurorehabil Neural Repair 2018 10 10;32(10):863-871. Epub 2018 Sep 10.

6 National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Background: Enhancement of sensory input in the form of repetitive peripheral sensory stimulation (RPSS) can enhance excitability of the motor cortex and upper limb performance.

Objective: To perform a systematic review and meta-analysis of effects of RPSS compared with control stimulation on improvement of motor outcomes in the upper limb of subjects with stroke.

Methods: We searched studies published between 1948 and December 2017 and selected 5 studies that provided individual data and applied a specific paradigm of stimulation (trains of 1-ms pulses at 10 Hz, delivered at 1 Hz). Read More

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http://dx.doi.org/10.1177/1545968318798943DOI Listing
October 2018
5 Reads

Course of Social Participation in the First 2 Years After Stroke and Its Associations With Demographic and Stroke-Related Factors.

Neurorehabil Neural Repair 2018 09 4;32(9):821-833. Epub 2018 Sep 4.

1 Maastricht University Medical Center, Netherlands.

Background: Many persons with stroke experience physical, cognitive, and emotional problems that contribute to restrictions in social participation. There is, however, a lack of knowledge on the long-term course of participation over time post-stroke.

Objective: To describe the time course of participation up to 2 years post-stroke and to identify which demographic and stroke-related factors are associated with this time course. Read More

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http://dx.doi.org/10.1177/1545968318796341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146317PMC
September 2018
1 Read

Modulation of Cerebellar Cortical Plasticity Using Low-Intensity Focused Ultrasound for Poststroke Sensorimotor Function Recovery.

Neurorehabil Neural Repair 2018 09 29;32(9):777-787. Epub 2018 Aug 29.

1 Center for Bionics, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.

Background: Stroke affects widespread brain regions through interhemispheric connections by influencing bilateral motor activity. Several noninvasive brain stimulation techniques have proved their capacity to compensate the functional loss by manipulating the neural activity of alternative pathways. Over the past few decades, brain stimulation therapies have been tailored within the theoretical framework of modulation of cortical excitability to enhance adaptive plasticity after stroke. Read More

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http://dx.doi.org/10.1177/1545968318790022DOI Listing
September 2018
5 Reads

Motor Impairment-Related Alterations in Biceps and Triceps Brachii Fascicle Lengths in Chronic Hemiparetic Stroke.

Neurorehabil Neural Repair 2018 09 23;32(9):799-809. Epub 2018 Aug 23.

2 Northwestern University, Evanston, IL, USA.

Poststroke deficits in upper extremity function occur during activities of daily living due to motor impairments of the paretic arm, including weakness and abnormal synergies, both of which result in altered use of the paretic arm. Over time, chronic disuse and a resultant flexed elbow posture may result in secondary changes in the musculoskeletal system that may limit use of the arm and impact functional mobility. This study utilized extended field-of-view ultrasound to measure fascicle lengths of the biceps (long head) and triceps (distal portion of the lateral head) brachii in order to investigate secondary alterations in muscles of the paretic elbow. Read More

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http://dx.doi.org/10.1177/1545968318792618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296776PMC
September 2018
3 Reads

Transcranial Direct Current Stimulation May Improve Cognitive-Motor Function in Functionally Limited Older Adults.

Neurorehabil Neural Repair 2018 09 22;32(9):788-798. Epub 2018 Aug 22.

1 Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, USA.

Objective: To determine the effects of a transcranial direct current stimulation (tDCS) intervention with the anode placed over the left dorsolateral prefrontal cortex (dlPFC) and cathode over the right supraorbital region, on cognition, mobility, and "dual-task" standing and walking in older adults with mild-to-moderate motor and cognitive impairments.

Methods: A double-blinded, block-randomized, sham-controlled trial was conducted in 18 nondemented, ambulatory adults aged ⩾65 years with slow walking speed (⩽1.0 m/s) and "executive" dysfunction (Trail Making Test B score ⩽25th percentile of age- and education-matched norms). Read More

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http://dx.doi.org/10.1177/1545968318792616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143414PMC
September 2018
16 Reads

Implementation Science: Ensuring the Return on Our Research Investment.

Authors:
Elaine H Morrato

Neurorehabil Neural Repair 2018 09 21;32(9):762-764. Epub 2018 Aug 21.

1 University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Implementation is the use of strategies to adopt and integrate evidence-based health interventions and to change practice patterns. In their article, "Implementation-the missing link in the research translation pipeline," Lynch et al report that only a small fraction of published stroke rehabilitation research in leading clinical journals evaluates the implementation of evidence-based interventions into health care practice. Their findings are a wake-up call. Read More

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http://dx.doi.org/10.1177/1545968318794904DOI Listing
September 2018
1 Read

A Dual-Learning Paradigm Simultaneously Improves Multiple Features of Gait Post-Stroke.

Neurorehabil Neural Repair 2018 09 7;32(9):810-820. Epub 2018 Aug 7.

1 The Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background: Gait impairments after stroke arise from dysfunction of one or several features of the walking pattern. Traditional rehabilitation practice focuses on improving one component at a time, which may leave certain features unaddressed or prolong rehabilitation time. Recent work shows that neurologically intact adults can learn multiple movement components simultaneously. Read More

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http://dx.doi.org/10.1177/1545968318792623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143413PMC
September 2018
1 Read

Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models.

Neurorehabil Neural Repair 2018 08 25;32(8):735-745. Epub 2018 Jul 25.

2 Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Peripheral axon regeneration is improved when the nerve lesion under consideration has recently been preceded by another nerve injury. This is known as the conditioning lesion effect (CLE). While the CLE is one of the most robust and well characterized means to enhance motor axon regeneration in experimental models, it is not considered a clinically feasible strategy. Read More

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http://dx.doi.org/10.1177/1545968318790020DOI Listing
August 2018
7 Reads

Eye Movements Interfere With Limb Motor Control in Stroke Survivors.

Neurorehabil Neural Repair 2018 08 25;32(8):724-734. Epub 2018 Jul 25.

1 University of South Carolina, Columbia, SC, USA.

Background: Humans use voluntary eye movements to actively gather visual information during many activities of daily living, such as driving, walking, and preparing meals. Most stroke survivors have difficulties performing these functional motor tasks, and we recently demonstrated that stroke survivors who require many saccades (rapid eye movements) to plan reaching movements exhibit poor motor performance. However, the nature of this relationship remains unclear. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318790016
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http://dx.doi.org/10.1177/1545968318790016DOI Listing
August 2018
39 Reads

Effects of Electrical Stimulation in Tinnitus Patients: Conventional Versus High-Definition tDCS.

Neurorehabil Neural Repair 2018 08 18;32(8):714-723. Epub 2018 Jul 18.

1 Department of Otorhinolaryngology and Head & Neck Surgery, Antwerp University Hospital, Edegem, Belgium.

Background: Contradictory results have been reported for transcranial direct current stimulation (tDCS) as treatment for tinnitus. The recently developed high-definition tDCS (HD tDCS) uses smaller electrodes to limit the excitation to the desired brain areas.

Objective: The current study consisted of a retrospective part and a prospective part, aiming to compare 2 tDCS electrode placements and to explore effects of HD tDCS by matched pairs analyses. Read More

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http://journals.sagepub.com/doi/10.1177/1545968318787916
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http://dx.doi.org/10.1177/1545968318787916DOI Listing
August 2018
5 Reads
3.980 Impact Factor

Impaired Callosal Motor Fiber Integrity and Upper Extremity Motor Impairment Are Associated With Stroke Lesion Location.

Neurorehabil Neural Repair 2018 06;32(6-7):602-612

1 National Taiwan University, Taipei, Taiwan.

Background: Damage to the callosal motor fibers (CMFs) may affect motor recovery in patients with stroke. However, whether the severity of CMF impairment varies with lesion locations remains unclear.

Objective: To investigate (1) whether CMF impairment occurs after stroke and whether the impairment varies with lesion locations and (2) the associations of CMF impairment and upper extremity (UE) motor impairment. Read More

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http://dx.doi.org/10.1177/1545968318779730DOI Listing
June 2018
4 Reads

Individual Differences in Locomotor Function Predict the Capacity to Reduce Asymmetry and Modify the Energetic Cost of Walking Poststroke.

Neurorehabil Neural Repair 2018 08 12;32(8):701-713. Epub 2018 Jul 12.

1 University of Southern California, Los Angeles, CA, USA.

Changes in the control of the lower extremities poststroke lead to persistent biomechanical asymmetries during walking. These asymmetries are associated with an increase in energetic cost, leading to the possibility that reducing asymmetry can improve walking economy. However, the influence of asymmetry on economy may depend on the direction and cause of asymmetry. Read More

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http://dx.doi.org/10.1177/1545968318787913DOI Listing
August 2018
1 Read

Is There Full or Proportional Somatosensory Recovery in the Upper Limb After Stroke? Investigating Behavioral Outcome and Neural Correlates.

Neurorehabil Neural Repair 2018 08 10;32(8):691-700. Epub 2018 Jul 10.

1 KU Leuven - University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium.

Background: Proportional motor recovery in the upper limb has been investigated, indicating about 70% of the potential for recovery of motor impairment within the first months poststroke.

Objective: To investigate whether the proportional recovery rule is applicable for upper-limb somatosensory impairment and to study underlying neural correlates of impairment and outcome at 6 months.

Methods: A total of 32 patients were evaluated at 4 to 7 days and 6 months using the Erasmus MC modification of the revised Nottingham Sensory Assessment (NSA) for impairment of (1) somatosensory perception (exteroception) and (2) passive somatosensory processing (sharp/blunt discrimination and proprioception); (3) active somatosensory processing was evaluated using the stereognosis component of the NSA. Read More

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http://dx.doi.org/10.1177/1545968318787060DOI Listing
August 2018
12 Reads