8,903 results match your criteria Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology[Journal]


Selective D and D receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens.

Neuropsychopharmacology 2019 Mar 16. Epub 2019 Mar 16.

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.

The dopamine D receptor (DR) has emerged as a promising pharmacotherapeutic target for the treatment of several diseases including schizophrenia, Parkinson's disease, and substance use disorders. However, studies investigating the DR's precise role in dopamine neurotransmission or how it may be exploited to modulate responses to drugs of abuse have produced contrasting results, in part because most DR-targeted compounds often also interact with D receptors (DR). To resolve this issue, we set out to systematically characterize and compare the consequences of selective DR or DR antagonists on the behavioral-stimulant properties of cocaine in mice, and to identify putative neurobiological mechanisms underlying their behavior-modifying effects. Read More

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http://dx.doi.org/10.1038/s41386-019-0371-2DOI Listing

Acute Inescapable Stress Rapidly Increases Synaptic Energy Metabolism in Prefrontal Cortex and Alters Working Memory Performance.

Cereb Cortex 2019 Mar 16. Epub 2019 Mar 16.

Laboratory of Neuropsychopharmacology and Functional Neurogenomics, Dipartimento di Scienze Farmacologiche e Biomolecolari and CEND, Università degli Studi di Milano, Milano, Italy.

Brain energy metabolism actively regulates synaptic transmission and activity. We have previously shown that acute footshock (FS)-stress induces fast and long-lasting functional and morphological changes at excitatory synapses in prefrontal cortex (PFC). Here, we asked whether FS-stress increased energy metabolism in PFC, and modified related cognitive functions. Read More

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https://academic.oup.com/cercor/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/cercor/bhz034DOI Listing
March 2019
1 Read

Ultrapotent chemogenetics for research and potential clinical applications.

Science 2019 Mar 14. Epub 2019 Mar 14.

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Chemogenetics enables non-invasive chemical control over cell populations in behaving animals. However, existing small molecule agonists show insufficient potency or selectivity. There is also need for chemogenetic systems compatible with both research and human therapeutic applications. Read More

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http://dx.doi.org/10.1126/science.aav5282DOI Listing

Break the net, break the cycle: removal of perineuronal nets in the lateral hypothalamus decreases cocaine relapse.

Neuropsychopharmacology 2019 Apr 24;44(5):835-836. Epub 2018 Oct 24.

Department of Anatomy and Neuroscience, Amsterdam Neuroscience, VU University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41386-018-0245-zDOI Listing

Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial.

Neuropsychopharmacology 2019 Mar 13. Epub 2019 Mar 13.

Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Short- and long-term antidepressant effects of deep brain stimulation (DBS) in treatment-resistant depression (TRD) have been demonstrated for several brain targets in open-label studies. For two stimulation targets, pivotal randomized trials have been conducted; both failed a futility analysis. We assessed efficacy and safety of DBS of the supero-lateral branch of the medial forebrain bundle (slMFB) in a small Phase I clinical study with a randomized-controlled onset of stimulation in order to obtain data for the planning of a large RCT. Read More

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http://dx.doi.org/10.1038/s41386-019-0369-9DOI Listing
March 2019
18 Reads
7.048 Impact Factor

Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine.

Neuropsychopharmacology 2019 Mar 13. Epub 2019 Mar 13.

Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.

Contemporary neurocognitive models of drug addiction have associated this condition with changes in interoception -namely, the sensing and processing of body signals that fulfill homeostatic functions relevant for the onset and maintenance of addictive behavior. However, most previous evidence is inconsistent, behaviorally unspecific, and virtually null in terms of direct electrophysiological and multimodal markers. To circumvent these limitations, we conducted the first assessment of the relation between cardiac interoception and smoked cocaine dependence (SCD) in a sample of (a) 25 participants who fulfilled criteria for dependence on such a drug, (b) 22 participants addicted to insufflated clorhidrate cocaine (only for behavioral assessment), and (c) 25 healthy controls matched by age, gender, education, and socioeconomic status. Read More

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http://www.nature.com/articles/s41386-019-0370-3
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http://dx.doi.org/10.1038/s41386-019-0370-3DOI Listing
March 2019
1 Read

Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects.

Neuropsychopharmacology 2019 Mar 13. Epub 2019 Mar 13.

Clinical Research Services, Turku CRST Ltd, Turku, Finland.

Nasal spray formulations of naloxone, a mu-opioid receptor (MOR) antagonist, are currently used for the treatment of opioid overdose. They may have additional therapeutic utility also in the absence of opioid agonist drugs, but the onset and duration of action at brain MORs have been inadequately characterized to allow such projections. This study provides initial characterization of brain MOR availability at high temporal resolution following intranasal (IN) naloxone administration to healthy volunteers in the absence of a competing opioid agonist. Read More

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http://www.nature.com/articles/s41386-019-0368-x
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http://dx.doi.org/10.1038/s41386-019-0368-xDOI Listing
March 2019
1 Read

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b cells and prevents depression-associated behaviors induced by chronic social defeat stress.

Neuropsychopharmacology 2019 Mar 13. Epub 2019 Mar 13.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

During this process, we found that we need add the following sentence in the manuscript within the Acknowledgement section. Read More

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http://dx.doi.org/10.1038/s41386-019-0354-3DOI Listing

Ting-Kai Li, M.D.

Authors:
David Goldman

Neuropsychopharmacology 2019 Mar 11. Epub 2019 Mar 11.

Laboratory of Neurogenetics, Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

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http://www.nature.com/articles/s41386-019-0358-z
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http://dx.doi.org/10.1038/s41386-019-0358-zDOI Listing
March 2019
1 Read

Correction: Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers.

Neuropsychopharmacology 2019 Mar 12. Epub 2019 Mar 12.

School of Life Science and Technology, Xidian University, 710071, Xi'an, Shaanxi, China.

The original version of this article contained an error in the affiliation of Dahua Yu, which was incorrectly stated as affiliation 3 (Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an Shaanxi, 710071, People's Republic of China), when this author is actually linked to affiliation 4 (Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014010, People's Republic of China). Read More

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http://dx.doi.org/10.1038/s41386-019-0330-yDOI Listing

Lithium continuation therapy following ketamine in patients with treatment resistant unipolar depression: a randomized controlled trial.

Neuropsychopharmacology 2019 Mar 11. Epub 2019 Mar 11.

Mood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is associated with rapid but transient antidepressant effects in patients with treatment resistant unipolar depression (TRD). Based on work suggesting that ketamine and lithium may share overlapping mechanisms of action, we tested lithium compared to placebo as a continuation strategy following ketamine in subjects with TRD. Participants who met all eligibility criteria and showed at least an initial partial response to a single intravenous infusion of ketamine 0. Read More

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http://dx.doi.org/10.1038/s41386-019-0365-0DOI Listing

Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders.

Neuropsychopharmacology 2019 Mar 11. Epub 2019 Mar 11.

Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, USA.

Medication-assisted treatments are unavailable to patients with cocaine use disorders. Efforts to develop potential pharmacotherapies have led to the identification of a promising lead molecule, JJC8-091, that demonstrates a novel binding mode at the dopamine transporter (DAT). Here, JJC8-091 and a structural analogue, JJC8-088, were extensively and comparatively assessed to elucidate neurochemical correlates to their divergent behavioral profiles. Read More

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http://dx.doi.org/10.1038/s41386-019-0366-zDOI Listing

Reconsolidation of sucrose instrumental memory in rats: the role of retrieval context.

Brain Res 2019 Mar 7. Epub 2019 Mar 7.

Neuropsychopharmacology Lab, Section Pharmacology, Department Diagnostic & Public Health, P.le Scuro 10, University of Verona, Verona, Italy.

Memory reconsolidation enables the update of a previously consolidated memory trace after its reactivation. Although Pavlovian memory reconsolidation has been widely demonstrated, instrumental memory reconsolidation is still debated. The most critical issue on instrumental memory reconsolidation findings have mainly been linked to the presence of specific boundary conditions for reactivation, for instance contextual parameters. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.006DOI Listing

Predicting relapse in major depression after successful initial pharmacological treatment.

J Affect Disord 2019 Mar 5;250:108-113. Epub 2019 Mar 5.

Kyoto University Graduate School of Medicine, School of Public Health Department of Health Promotion of Human Behavior, Kyoto, Japan.

Background: Identifying the predictors of relapse could help to develop more individualized treatment strategies for major depression. The study aim was to explore predictors of depression relapse after remission using data from our previous multicenter randomized practical trial of patients with major depression.

Methods: Our cohort comprised subjects with Patient Health Questionnaire (PHQ-9) scores less than 5 after antidepressant treatment for 9 weeks. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.004DOI Listing
March 2019
3 Reads

Novel insights into the mechanisms underlying depression-associated experimental autoimmune encephalomyelitis.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Mar 5;93:1-10. Epub 2019 Mar 5.

Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, PE, Brazil; Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. Electronic address:

Multiple Sclerosis (MS) is a chronic autoimmune disease characterized by neuroinflammation, demyelination and neuroaxonal degeneration affecting >2 million people around the world. MS is often accompanied by psychiatric comorbidities such as major depressive disorder (MDD), which presents a lifetime prevalence of around 50% in MS patients. Experimental Autoimmune Encephalomyelitis (EAE) is an animal model extensively used to study MS. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.03.001DOI Listing
March 2019
1 Read

Correction: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels.

Neuropsychopharmacology 2019 Mar 8. Epub 2019 Mar 8.

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, 2100, Denmark.

The original version of this article contained an error in the labelling of Figures 2 and 3. While the captions and figures themselves are correct, in order to correspond with the in-text references, they have now been re-numbered in both the PDF and HTML versions of the article. Read More

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http://dx.doi.org/10.1038/s41386-019-0360-5DOI Listing

In memoriam: Conan Kornetsky, B.A., D.Phil., M.A.

Neuropsychopharmacology 2019 Mar 7. Epub 2019 Mar 7.

Penn State Hershey College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1038/s41386-019-0352-5DOI Listing

Lewis Judd, M.D.

Neuropsychopharmacology 2019 Mar 7. Epub 2019 Mar 7.

Department of Psychiatry, UC San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1038/s41386-019-0359-yDOI Listing
March 2019
1 Read

Differences in the regulation of inflammatory pathways in adolescent- and adult-onset first-episode psychosis.

Eur Child Adolesc Psychiatry 2019 Mar 6. Epub 2019 Mar 6.

Department of Pharmacology and Toxicology, Faculty of Medicine, UCM, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), IUINQ, Madrid, Spain.

A precise description of the inflammatory response in first-episode psychosis (FEP) by age of onset does not exist. We explored baseline and 6-month follow-up differences in the pro/anti-inflammatory balance in plasma and peripheral blood mononuclear cells in adolescent-onset FEP (≤ 18 y.o. Read More

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http://link.springer.com/10.1007/s00787-019-01295-8
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http://dx.doi.org/10.1007/s00787-019-01295-8DOI Listing
March 2019
2 Reads

Altered anticipation and processing of aversive interoceptive experience among women remitted from bulimia nervosa.

Neuropsychopharmacology 2019 Mar 6. Epub 2019 Mar 6.

Department of Psychiatry, University of California, Chancellor Park, 4510 Executive Dr., Suite 330, San Diego, CA, 92121-3021, USA.

Bulimia nervosa (BN) is characterized by dysregulated intake of food, which may indicate homeostatic imbalance. Critically important for homeostatic regulation is interoception, or the sensing and processing of body-relevant information. A well-documented link between avoidance of unpleasant body sensations and BN symptoms suggests that aversive interoceptive events may be particularly relevant to BN pathophysiology. Read More

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http://dx.doi.org/10.1038/s41386-019-0361-4DOI Listing
March 2019
4 Reads

Comparing Mental Health across Distinct Groups of Users of Psychedelics, MDMA, Psychostimulants, and Cannabis.

J Psychoactive Drugs 2019 Mar 6:1-11. Epub 2019 Mar 6.

e Addiction Medicine Center , Department of Psychiatry, Lausanne University Hospital , Lausanne , Switzerland.

Differences in mental health (MH) of users of distinct psychoactive substances have been shown. Both substance use (SU) and MH in users are influenced by stressful life events. This study compared MH parameters in distinct groups of substance users and evaluated the impact of stress factors on these outcomes. Read More

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http://dx.doi.org/10.1080/02791072.2019.1571258DOI Listing
March 2019
1 Read

Linking PANSS negative symptom scores with the Clinical Global Impressions Scale: understanding negative symptom scores in schizophrenia.

Neuropsychopharmacology 2019 Mar 5. Epub 2019 Mar 5.

Medical Division, Gedeon Richter Plc, Budapest, Hungary.

Understanding how rating scale improvement corresponds to a clinical impression in patients with negative symptoms of schizophrenia may help define the clinical relevance of change in this patient population. We conducted post hoc equipercentile linking analyses of Positive and Negative Syndrome Scale (PANSS) outcomes (e.g. Read More

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http://dx.doi.org/10.1038/s41386-019-0363-2DOI Listing
March 2019
1 Read

Women using hormonal contraceptives show increased valence ratings and memory performance for emotional information.

Neuropsychopharmacology 2019 Mar 5. Epub 2019 Mar 5.

Division of Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.

Perception of emotional valence and emotional memory performance vary across the menstrual cycle. However, the consequences of altered ovarian hormone levels due to the intake of hormonal contraceptives on these emotional and cognitive processes remain to be established. In the present study, which included 2169 healthy young females, we show that hormonal contraceptives (HC) users rated emotional pictures as more emotional than HC-non-users and outperformed non-users in terms of better memory recall of emotional pictures. Read More

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http://dx.doi.org/10.1038/s41386-019-0362-3DOI Listing

Even More Complex…. When Mental Disorder Meets Addiction in Youth: Dual Pathology.

Curr Drug Res Rev 2019 ;11(1):40-43

Departamento de Psiquiatria, Universidad Nacional de Asuncion, Asuncion, Paraguay.

Background: The management of mental disorders in child and adolescent is challenging. In addition, when substance use disorders are associated with mental disorders, important complications are noted. Dual pathology and Substance-induced disorders should be distinguished in cases like this. Read More

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http://dx.doi.org/10.2174/2589977511666181128165358DOI Listing
January 2019
1 Read

Buzzkill: the consequences of depleting anandamide in the hippocampus.

Neuropsychopharmacology 2019 Mar 1. Epub 2019 Mar 1.

Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N4N1, Canada.

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http://dx.doi.org/10.1038/s41386-019-0357-0DOI Listing

Effects of gamma-hydroxybutyrate on neurophysiological correlates of performance and conflict monitoring.

Eur Neuropsychopharmacol 2019 Feb 26. Epub 2019 Feb 26.

Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, CH-8032 Zurich, Switzerland; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland.

Performance and conflict monitoring (PM and CM) represent two essential cognitive abilities, required to respond appropriately to demanding tasks. PM and CM can be investigated using event-related brain potentials (ERP) and associated neural oscillations. Namely, the error-related negativity (ERN) represents a correlate of PM, whereas the N2 component reflects the process of CM. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.02.004DOI Listing
February 2019
1 Read

Randomized, double-blind, placebo-controlled study of F17464, a preferential D antagonist, in the treatment of acute exacerbation of schizophrenia.

Neuropsychopharmacology 2019 Mar 1. Epub 2019 Mar 1.

Institut de Recherche Pierre Fabre, 3 avenue Hubert Curien, Toulouse, 31000, France.

F17464, a highly potent preferential D antagonist, is a novel compound in development for schizophrenia treatment. This phase II, double-blind, randomized, placebo-controlled, parallel-group study in five European countries evaluated the efficacy and safety of F17464, 20 mg twice daily, versus placebo over 6 weeks in patients with acute exacerbation of schizophrenia. Change from baseline to Day 43 of the Positive and Negative Syndrome Scale (PANSS) total score was the primary outcome. Read More

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http://www.nature.com/articles/s41386-019-0355-2
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http://dx.doi.org/10.1038/s41386-019-0355-2DOI Listing
March 2019
4 Reads

Far-infrared ray-mediated antioxidant potentials are important for attenuating psychotoxic disorders.

Curr Neuropharmacol 2019 Feb 27. Epub 2019 Feb 27.

Neuropsychopharmacology and Toxicology Program, BK21 PLUS Project, College of Pharmacy, Kangwon National University, Chunchon 24341. Korea.

Far-infrared ray (FIR) is an electromagnetic wave that produces various health benefits against pathophysiological conditions, such as diabetes mellitus, renocardiovascular disorders, stress, and depression etc. However, the therapeutic application on the FIR-mediated protective potentials remains to be further extended. To achieve the better understanding on FIR-mediated therapeutic potentials, we summarized additional findings in the present study that exposure to FIR ameliorates stressful condition, memory impairments, drug dependence, and mitochondrial dysfunction in the central nervous system. Read More

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http://dx.doi.org/10.2174/1570159X17666190228114318DOI Listing
February 2019

Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats.

Neuropsychopharmacology 2019 Feb 28. Epub 2019 Feb 28.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.

Clinical evidence suggest that men are more sensitive than women to the abuse-related effects of mu-opioid agonists. In contrast, preclinical studies suggest the opposite sex difference. The aim of the present study was to clarify this discrepancy using a fentanyl vs. Read More

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http://dx.doi.org/10.1038/s41386-019-0356-1DOI Listing
February 2019
4 Reads

Reduced focal fiber collinearity in the cingulum bundle in adults with obsessive-compulsive disorder.

Neuropsychopharmacology 2019 Feb 25. Epub 2019 Feb 25.

Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.

Obsessive-compulsive disorder (OCD) is a disabling condition, often associated with a chronic course. Given its role in attentional control, decision-making, and emotional regulation, the anterior cingulate cortex is considered to have a key role in the pathophysiology of the disorder. Notably, the cingulum bundle, being the major white matter tract connecting to this region, has been historically a target for the surgical treatment of intractable OCD. Read More

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http://dx.doi.org/10.1038/s41386-019-0353-4DOI Listing
February 2019
1 Read

Lower serum osteocalcin concentrations in patients with type 2 diabetes and relationships with vascular risk factors among patients with coronary artery disease.

J Diabetes Complications 2019 Jan 17. Epub 2019 Jan 17.

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada; Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, Canada; University Health Network Toronto Rehabilitation Institute, Toronto, Canada. Electronic address:

Background: Lower serum concentrations of the osteoblast-derived protein, osteocalcin, have been associated with poorer glycemic control, insulin resistance and atherosclerosis, and with the development of type 2 diabetes (T2DM).

Methods: This study compares concentrations of two physiological forms of osteocalcin, carboxylated (cOCN) and uncarboxylated (unOCN), between participants with T2DM (n = 20) and age-, gender- and body mass index (BMI)-matched participants without T2DM (n = 40) among patients with coronary artery disease (CAD), and it explores relationships between osteocalcin concentrations and cardiovascular risk factors.

Results: Concentrations of unOCN (2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183131
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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.003DOI Listing
January 2019
6 Reads

Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations.

Metab Brain Dis 2019 Feb 23. Epub 2019 Feb 23.

Surgery Department, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil.

Endometriosis is a gynecological condition affecting 10% of women in reproductive age. High rates of depression and anxiety are observed in these patients. The mechanisms underlying endometriosis-induced behavioral alterations are still elusive. Read More

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http://dx.doi.org/10.1007/s11011-019-00397-1DOI Listing
February 2019
2 Reads

Effects of clonidine on MMN and P3a amplitude in schizophrenia patients on stable medication.

Neuropsychopharmacology 2019 Feb 23. Epub 2019 Feb 23.

Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, University of Copenhagen, Copenhagen, Denmark.

Schizophrenia is a complex brain disease involving several neurotransmitter systems, including aberrant noradrenergic activity, which might underlie cognitive deficits. Clonidine is an α-agonist and previous research has demonstrated that single dosages of clonidine normalize sensori(motor) gating in schizophrenia. Currently, we investigated whether clonidine is able to normalize mismatch negativity (MMN) and P3a amplitude deficits in this same group of patients. Read More

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http://dx.doi.org/10.1038/s41386-019-0351-6DOI Listing
February 2019

Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis.

Neuropsychopharmacology 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Thurston Bowles Building 104 Manning Drive, Chapel Hill, NC, 27599, USA.

Contextual cues associated with drugs of abuse, such as ethanol, can trigger craving and drug-seeking behavior. Pavlovian procedures, such as place conditioning, have been widely used to study the rewarding/aversive properties of drugs and the association between environmental cues and drug seeking. Previous research has shown that ethanol as an unconditioned stimulus can induce a strong conditioned place preference (CPP) or aversion (CPA) in rodents. Read More

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http://dx.doi.org/10.1038/s41386-019-0349-0DOI Listing
February 2019

Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia.

Neuropsychopharmacology 2019 Feb 22. Epub 2019 Feb 22.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Previously, we demonstrated that dendritic spine density (DSD) in deep layer 3 of the primary auditory cortex (A1) is lower, due to having fewer small spines, in subjects with schizophrenia (SZ) than non-psychiatric control (NPC) subjects. We also previously demonstrated that microtubule-associated-protein-2 immunoreactivity (MAP2-IR) in A1 deep layer 3 is lower, and positively correlated with DSD, in SZ subjects. Here, we first sought to confirm these findings in an independent cohort of 25 SZ-NPC subject pairs (cohort 1). Read More

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http://dx.doi.org/10.1038/s41386-019-0350-7DOI Listing
February 2019
1 Read

Correction: Behavioral and synaptic alterations relevant to obsessivecompulsive disorder in mice with increased EAAT3 expression.

Neuropsychopharmacology 2019 Feb 21. Epub 2019 Feb 21.

Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

The original version of this Article contained an error in the spelling of the author Anna K Radke, which was incorrectly given as Anna R Radke. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41386-019-0331-xDOI Listing
February 2019
1 Read

Switching winter and summer photoperiods in an animal model of bipolar disorder.

Neuropsychopharmacology 2019 Feb 20. Epub 2019 Feb 20.

Departments of Psychology, Vanderbilt University, Nashville, TN, 37240, USA.

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http://dx.doi.org/10.1038/s41386-019-0337-4DOI Listing
February 2019
1 Read

Evidence for light-entrainment-induced switching between depression- & mania-relevant behaviors in mice.

Neuropsychopharmacology 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA.

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http://dx.doi.org/10.1038/s41386-019-0338-3DOI Listing
February 2019

Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA.

Neuropsychopharmacology 2019 Feb 20. Epub 2019 Feb 20.

School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia.

Circular RNAs (circRNAs) are a covalently closed subclass of non-coding RNA molecules formed by back splicing of linear precursor RNA. These molecules are relatively stable and particularly abundant in the mammalian brain and therefore may participate in neural development and function. With the emergence of circRNAs activity in gene regulation, these molecules have been implicated in several biological processes, including synaptic plasticity, and we therefore suspect they may have a role in neurobehavioral disorders. Read More

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http://dx.doi.org/10.1038/s41386-019-0348-1DOI Listing
February 2019
2 Reads

Cognitive deficits in problematic internet use: meta-analysis of 40 studies.

Br J Psychiatry 2019 Feb 20:1-8. Epub 2019 Feb 20.

Department of Psychiatry,University of Cambridge; andPeterborough NHS Foundation Trust,Cambridge,UK.

Background: Excessive use of the internet is increasingly recognised as a global public health concern. Individual studies have reported cognitive impairment in problematic internet use (PIU), but have suffered from various methodological limitations. Confirmation of cognitive deficits in PIU would support the neurobiological plausibility of this disorder. Read More

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http://dx.doi.org/10.1192/bjp.2019.3DOI Listing
February 2019
1 Read

Cannabis use in youth is associated with limited alterations in brain structure.

Neuropsychopharmacology 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Frequent cannabis use during adolescence has been associated with alterations in brain structure. However, studies have featured relatively inconsistent results, predominantly from small samples, and few studies have examined less frequent users to shed light on potential brain structure differences across levels of cannabis use. In this study, high-resolution T1-weighted MRIs were obtained from 781 youth aged 14-22 years who were studied as part of the Philadelphia Neurodevelopmental Cohort. Read More

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http://dx.doi.org/10.1038/s41386-019-0347-2DOI Listing
February 2019
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Adolescence versus adulthood: Differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse.

Addict Biol 2019 Feb 18. Epub 2019 Feb 18.

National Research Council of Italy, Institute of Neuroscience, Italy.

Epidemiological studies have shown that people who begin experimenting drugs of abuse during adolescence are more likely to develop substance use disorders, and the earliest is the beginning of their use, the greatest is the likelihood to become dependent. Understanding the neurobiological changes increasing adolescent vulnerability to drug use is becoming imperative. Although all neurotransmitter systems undergo relevant developmental changes, dopamine system is of particular interest, given its role in a variety of functions related to reward, motivation, and decision making. Read More

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http://dx.doi.org/10.1111/adb.12721DOI Listing
February 2019
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BDNF polymorphism in non-veridical decision making and differential effects of rTMS.

Behav Brain Res 2019 Feb 15;364:177-182. Epub 2019 Feb 15.

Department of Penal Law, School of Law, University of Tartu (Tallinn branch), Kaarli puiestee 3, 10119 Tallinn, Estonia.

Making decisions when an objectively correct option is not obvious, involves different neurobiological mechanisms than "veridical" decision making. The dorsolateral prefrontal cortex (DLPFC) exhibits a distinct pattern of prefrontal activation in non-veridical cognition, but little is known about the role of underlying neurobiological endophenotypes. A functional polymorphism in the brain-derived neurotrophic factor (BDNF) gene, causing a valine (Val) to methionine (Met) amino acid substitution at codon 66, has been shown to be associated with structural and functional changes in DLPFC and affect veridical decision making. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.027DOI Listing
February 2019
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Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, Yunnan, China.

Major depressive disorder (MDD) is the most prevalent mental disorder that affects more than 200 million people worldwide. Recent large-scale genome-wide association studies (GWAS) have identified multiple risk variants that show robust association with MDD. Nevertheless, how the identified risk variants confer risk of MDD remains largely unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0345-4DOI Listing
February 2019
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Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying biological mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, including the emotional and cognitive-related phenotypes. Read More

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http://dx.doi.org/10.1038/s41386-019-0346-3DOI Listing
February 2019
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7.048 Impact Factor

Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction.

Neuropsychopharmacology 2019 Feb 15. Epub 2019 Feb 15.

Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.

NETO1 and NETO2 are auxiliary subunits of kainate receptors (KARs). They interact with native KAR subunits to modulate multiple aspects of receptor function. Variation in KAR genes has been associated with psychiatric disorders in humans, and in mice, knockouts of the Grik1 gene have increased, while Grik2 and Grik4 knockouts have reduced anxiety-like behavior. Read More

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http://dx.doi.org/10.1038/s41386-019-0344-5DOI Listing
February 2019
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The myeloarchitecture of impulsivity: premature responding in youth is associated with decreased myelination of ventral putamen.

Neuropsychopharmacology 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychiatry, University of Cambridge, Cambridge, UK.

Impulsivity has been suggested as a neurocognitive endophenotype conferring risk across a number of neuropsychiatric conditions, including substance and behavioural addictions, eating disorders, and attention deficit/hyperactivity disorder. We used a paradigm with interspecies translation validity (the four-choice serial reaction time task, 4CSRTT) to assess 'waiting' impulsivity in a youth sample (N = 99, aged 16-26 years). We collected magnetization prepared two rapid acquisition gradient echo (MP2RAGE) scans, which enabled us to measure R1, the longitudinal relaxation rate, a parameter closely related to tissue myelin content, as well as quantify grey matter volume. Read More

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http://dx.doi.org/10.1038/s41386-019-0343-6DOI Listing
February 2019
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Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells.

Toxicol Res 2019 Jan 15;35(1):83-91. Epub 2018 Jan 15.

Department of Veterinary Toxicology, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Korea.

Nanoparticles (NPs) have been recognized as both useful tools and potentially toxic materials in various industrial and medicinal fields. Previously, we found that zinc oxide (ZnO) NPs that are neurotoxic to human dopaminergic neuroblastoma SH-SY5Y cells are mediated by lipoxygenase (LOX), not cyclooxygenase-2 (COX-2). Here, we examined whether human bone marrow-derived mesenchymal stem cells (MSCs), which are different from neuroblastoma cells, might exhibit COX-2- and/or LOX-dependent cytotoxicity of ZnO NPs. Read More

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http://dx.doi.org/10.5487/TR.2019.35.1.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354944PMC
January 2019
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Anxiety, the chicken or the egg of addiction: targeting G9a for the treatment of comorbid anxiety and cocaine addiction.

Neuropsychopharmacology 2019 Feb 13. Epub 2019 Feb 13.

Pediatric Neurology, Pediatrics, Weill Cornell Medicine, New York, NY, 10065, USA.

Treating cocaine addiction is a major challenge and currently no FDA approved pharmacotherapies exist. One complicating factor is a high rate of comorbidity between cocaine and neuropsychiatric conditions such as anxiety. The relationship between anxiety symptoms and cocaine addiction is complicated; anxiety can be both a predisposing factor and a consequence of cocaine use as anxiety symptoms often emerge during drug use and withdrawal. Read More

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http://dx.doi.org/10.1038/s41386-019-0329-4DOI Listing
February 2019

Prefrontal-amygdala plasticity enabled by observational fear.

Neuropsychopharmacology 2019 Feb 13. Epub 2019 Feb 13.

Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA.

Observing fear in others (OF) is a form of social stress. In mice, it enhances inhibitory avoidance learning and causes the formation of silent synapses in the prefrontal-amygdala pathway. Here, we report that OF made that pathway prone to facilitation both ex vivo and in vivo. Read More

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http://dx.doi.org/10.1038/s41386-019-0342-7DOI Listing
February 2019
4 Reads