8,752 results match your criteria Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology[Journal]


ACNP 57 Annual Meeting: Poster Session I.

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Neuropsychopharmacology 2018 Dec 6. Epub 2018 Dec 6.

Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.Individual contributor disclosures may be found within the abstracts. Asterisks in the author lists indicate presenter of the abstract at the annual meeting. Read More

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December 2018

ACNP 57 Annual Meeting: Poster Session III.

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Neuropsychopharmacology 2018 Dec 6. Epub 2018 Dec 6.

Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.Individual contributor disclosures may be found within the abstracts. Asterisks in the author lists indicate presenter of the abstract at the annual meeting. Read More

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December 2018

ACNP 57 Annual Meeting: Poster Session II.

Authors:

Neuropsychopharmacology 2018 Dec 6. Epub 2018 Dec 6.

Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.Individual contributor disclosures may be found within the abstracts. Asterisks in the author lists indicate presenter of the abstract at the annual meeting. Read More

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December 2018

ACNP 57 Annual Meeting: Panels, Mini-Panels and Study Groups.

Authors:

Neuropsychopharmacology 2018 Dec 6. Epub 2018 Dec 6.

Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.Individual contributor disclosures may be found within the abstracts.Asterisks in the author lists indicate presenter of the abstract at the annual meeting. Read More

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December 2018

ACNP 57th Annual Meeting: Author Index.

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Neuropsychopharmacology 2018 Dec 6. Epub 2018 Dec 6.

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December 2018

ACNP 57th Annual Meeting: Keyword Index.

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Neuropsychopharmacology 2018 Dec 6. Epub 2018 Dec 6.

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December 2018

N-3 polyunsaturated fatty acids and clozapine abrogates poly I: C-induced immune alterations in primary hippocampal neurons.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Nov 30. Epub 2018 Nov 30.

Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil. Electronic address:

The viral mimetic polyinosinic:polycytidylic acid (poly I:C) is an important tool to study the consequences of viral infection to the development of neuropsychiatric disorders. Here, based on the premise of omega-3 polyunsaturated fatty acids (n3 PUFAs) as supplemental treatment to antipsychotics in schizophrenia, we investigated the involvement of NFkB pathway in the effects of n3 PUFAs or of the atypical antipsychotic clozapine in hippocampal poly I:C-challenged neurons. Primary hippocampal neuronal cultures were exposed to n3 PUFAs (DHA4. Read More

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November 2018
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Methylphenidate's effects on thalamic metabolism and functional connectivity in cannabis abusers and healthy controls.

Neuropsychopharmacology 2018 Dec 1. Epub 2018 Dec 1.

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

Methylphenidate (MPH) is a first line treatment for ADHD and is also misused as a purported cognitive enhancer, yet its effects on brain function are still poorly understood. Recent functional magnetic resonance imaging (fMRI) studies showed that MPH altered cortico-striatal resting functional connectivity (RFC). Here we investigated the effects of MPH in thalamic connectivity since the thalamus modulates striato-cortical signaling. Read More

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December 2018

D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors.

Neuropsychopharmacology 2018 Dec 1. Epub 2018 Dec 1.

Laboratory on the Neurobiology of Compulsive Behaviors, National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program, NIH, Bethesda, MD, USA.

Vulnerability for cocaine abuse in humans is associated with low dopamine D2 receptor (D2R) availability in the striatum. The mechanisms driving this vulnerability are poorly understood. In this study, we found that downregulating D2R expression selectively in striatal indirect-pathway neurons triggers a multitude of changes in D1 receptors (D1R)-expressing direct-pathway neurons, which comprise the other main subpopulation of striatal projection neurons. Read More

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December 2018

Rate matters: rapid cocaine delivery promotes incubation of cocaine craving.

Neuropsychopharmacology 2018 Nov 30. Epub 2018 Nov 30.

Department of Psychology, University of Maryland College Park, College Park, MD, USA.

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November 2018

VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine.

Neuropsychopharmacology 2018 Nov 20. Epub 2018 Nov 20.

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Patients with major depressive disorder (MDD) often have structural and functional deficits in the ventromedial prefrontal cortex (vmPFC), but the underlying molecular pathways are incompletely understood. The neuropeptide precursor VGF (non-acronymic) plays a critical role in depression and antidepressant efficacy in hippocampus and nucleus accumbens, however its function in vmPFC has not been investigated. Here, we show that VGF levels were reduced in Brodmann area 25 (a portion of human vmPFC) of MDD patients and in mouse vmPFC following chronic restraint stress (CRS), and were increased by ketamine in mouse vmPFC. Read More

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November 2018

Multiple-therapy-resistant major depressive disorder: a clinically important concept.

Br J Psychiatry 2018 May;212(5):274-278

Centre for Affective Disorders,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London and South London and Maudsley NHS Foundation Trust,London.

SummaryMany novel therapeutic options for depression exist that are either not mentioned in clinical guidelines or recommended only for use in highly specialist services. The challenge faced by clinicians is when it might be appropriate to consider such 'non-standard' interventions. This analysis proposes a framework to aid this decision. Read More

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May 2018
1 Read

Does relapse contribute to treatment resistance? Antipsychotic response in first- vs. second-episode schizophrenia.

Neuropsychopharmacology 2018 Nov 22. Epub 2018 Nov 22.

Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Although some studies have suggested that relapse may be associated with antipsychotic treatment resistance in schizophrenia, the number and quality of studies is limited. The current analysis included patients with a diagnosis of first-episode schizophrenia or schizoaffective disorder who met the following criteria: (1) referral to the First-Episode Psychosis Program between 2003 and 2013; (2) treatment with an oral second-generation antipsychotic according to a standardized treatment algorithm; (3) positive symptom remission; (4) subsequent relapse (i.e. Read More

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November 2018
1 Read

Protective potentials of far-infrared ray against neuropsychotoxic conditions.

Neurochem Int 2018 Nov 28;122:144-148. Epub 2018 Nov 28.

Neuropsychopharmacology and Toxicology Program, BK21 PLUS Project, College of Pharmacy, Kangwon National University, Chunchon, Republic of Korea. Electronic address:

Compelling evidence suggests that far-infrared ray (FIR) possesses beneficial effects on emotional disorders. However, the underlying mechanism conveyed by FIR remains unclear. Recently, we demonstrated that exposure to FIR induces antioxidant potentials via up-regulation of glutathione peroxidase (GPx)-1 gene. Read More

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November 2018
3 Reads

Correction to: Imaging and Genetic Approaches to Inform Biomarkers for Anxiety Disorders, Obsessive-Compulsive Disorders, and PSTD.

Curr Top Behav Neurosci 2018 Oct 24. Epub 2018 Oct 24.

Neuropsychopharmacology Unit, Centre for Academic Psychiatry, Division of Brain Sciences, Imperial College London, London, UK.

This chapter was inadvertently published with Fig. 1 which do not belong to this chapter and hence Fig. 1 is deleted from this chapter later. Read More

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October 2018

Correction: Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression.

Neuropsychopharmacology 2018 Nov 28. Epub 2018 Nov 28.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Following the publication of this article the authors noted an error in Fig. 5. The units of blood concentration for ketamine and norketamine should be ng/mL, as per the assay details in Materials and methods section, and not nM/ml as presented in the figure. Read More

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November 2018

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder.

Neuropsychopharmacology 2018 Nov 16. Epub 2018 Nov 16.

Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USA.

Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Read More

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November 2018
2 Reads

D2 receptors and cognitive flexibility in marmosets: tri-phasic dose-response effects of intra-striatal quinpirole on serial reversal performance.

Neuropsychopharmacology 2018 Nov 15. Epub 2018 Nov 15.

Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.

Behavioral flexibility, which allows organisms to adapt their actions in response to environmental changes, is impaired in a number of neuropsychiatric conditions, including obsessive-compulsive disorder and addiction. Studies in human subjects and monkeys have reported correlations between individual differences in dopamine D2-type receptor (D2R) levels in the caudate nucleus and performance in a discrimination reversal task, in which established contingent relationships between abstract stimuli and rewards (or punishments) are reversed. Global genetic deletion of the D2R in mice disrupts reversal performance, indicating a likely causal role for this receptor in supporting flexible behaviors. Read More

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November 2018
1 Read

Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation.

Neuropsychopharmacology 2018 Nov 27. Epub 2018 Nov 27.

Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.

Disruptions to motivated behaviour are a highly prevalent and severe symptom in a number of neuropsychiatric and neurodegenerative disorders. Current treatment options for these disorders have little or no effect upon motivational impairments. We assessed the contribution of muscarinic acetylcholine receptors to motivated behaviour in mice, as a novel pharmacological target for motivational impairments. Read More

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November 2018
2 Reads

Factors Associated With Cysticidal Treatment Response in Extraparenchymal Neurocysticercosis.

J Clin Pharmacol 2018 Nov 26. Epub 2018 Nov 26.

Neuroinflammation Unit, IIBM-UNAM/INNN/Facultad de Medicina- UNAM, Ciudad de México, México.

Extraparenchymal neurocysticercosis is the most severe form of cysticercosis, and response to treatment is suboptimal. We sought to determine how demographic and clinical characteristics and albendazole sulfoxide concentrations were related to cysticidal treatment response. We conducted a longitudinal study of 31 participants with extraparenchymal vesicular parasites who received the same treatment, albendazole 30 mg/kg/day for 10 days with dexamethasone 0. Read More

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November 2018
3 Reads

Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity.

Acta Neuropsychiatr 2018 Nov 26:1-9. Epub 2018 Nov 26.

1Division of Neuropsychopharmacology, Department of Psychology,University of Tartu,Estonia.

Objective: Individual biological predispositions should play a role in risky driving behaviour. Platelet monoamine oxidase (MAO) activity, dopamine transporter gene (DAT1) and neuropeptide S receptor 1 (NPSR1) gene polymorphisms have been identified as markers of impulsivity, alcohol use and excessive risk-taking. We aimed to find out how this knowledge on neurobiology of impulsivity applies to drunk driving and traffic behaviour in general. Read More

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November 2018

Measuring novel antecedents of mental illness: the Questionnaire of Unpredictability in Childhood.

Neuropsychopharmacology 2018 Nov 23. Epub 2018 Nov 23.

Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.

Increasing evidence indicates that, in addition to poverty, maternal depression, and other well-established factors, unpredictability of maternal and environmental signals early in life influences trajectories of brain development, determining risk for subsequent mental illness. However, whereas most risk factors for later vulnerability to mental illness are readily measured using existing, clinically available tools, there are no similar measures for assessing early-life unpredictability. Here we validate the Questionnaire of Unpredictability in Childhood (QUIC) and examine its associations with mental health in the context of other indicators of childhood adversity (e. Read More

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November 2018

Predator odor increases avoidance and glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling.

Neuropsychopharmacology 2018 Nov 23. Epub 2018 Nov 23.

Departments of Pharmacology, Neuroscience, and the Bowles Alcohol Research Center, University of North Carolina School of Medicine, 104 Manning Drive, Chapel Hill, NC, 27599, USA.

Acute exposure to a salient stressor, such as in post-traumatic stress disorder, can have lasting impacts upon an individual and society. To study stress in rodents, some naturalistic methods have included acute exposure to a predator odor, such as the synthetic fox odor 2,4,5, trimethyl-3-thiazoline (TMT). These experiments explore the stress-related behaviors and cortical activity induced by TMT exposure in adult male C57BL/6J mice and the influence of the stress neuropeptide corticotropin-releasing factor (CRF) on these responses. Read More

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November 2018
3 Reads

Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review.

Metab Brain Dis 2018 Nov 22. Epub 2018 Nov 22.

Neuropsychopharmacology Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Coronel Nunes de Melo Street, 1127, Fortaleza, CE, 60431-270, Brazil.

Despite the existence of many preclinical studies, scientific evidence is lacking on the clinical use of alpha-lipoic acid (ALA) for central nervous system disorders. Therefore, we aimed at revising the literature concerning the use of ALA for the treatment of psychiatric and neurological conditions and to point out what is missing for the introduction of this antioxidant to this purpose. For this systematic review we performed a search using PubMed and SCOPUS databases with the following keywords: "alpha-Lipoic Acid AND central nervous system OR psychiatric disorders OR neurological disorders OR mood disorders OR anxiety OR psychosis OR Alzheimer OR Parkinson OR stroke". Read More

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November 2018
8 Reads

Sex-dependent regulation of social reward by oxytocin receptors in the ventral tegmental area.

Neuropsychopharmacology 2018 Nov 6. Epub 2018 Nov 6.

Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA, USA.

Social reward is critical for social relationships, and yet we know little about the characteristics of social interactions that are rewarding or the neural mechanisms underlying that reward. Here, we investigate the sex-dependent role of oxytocin receptors within the ventral tegmental area (VTA) in mediating the magnitude and valence of social reward. Operant and classical conditioning tests were used to measure social reward associated with same-sex social interactions. Read More

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November 2018
5 Reads

Lower Choline Rate in the Left Prefrontal Cortex Is Associated With Higher Amount of Alcohol Use in Alcohol Use Disorder.

Front Psychiatry 2018 7;9:563. Epub 2018 Nov 7.

BRAEN - Brazilian Research Group on Brain and Cognitive Engineering, Federal University of Espírito Santo, Vitória, Brazil.

Excessive and long-term alcohol consumption produce metabolic changes, such as of choline, in many brain regions in alcohol use disorder (AUD) and in non-AUD subjects as well. This study examined the association of choline proportion in the prefrontal cortex with pattern of alcohol use in AUD patients. The choline metabolite was acquired through a single voxel Proton Magnetic Resonance Spectroscopy (H MRS). Read More

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November 2018
3 Reads

Nausea in the peri-traumatic period is associated with prospective risk for PTSD symptom development.

Neuropsychopharmacology 2018 Nov 21. Epub 2018 Nov 21.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

While nausea often develops following exposure to trauma, little is known regarding the relationship between peri-traumatic nausea and prospective risk for developing posttraumatic stress disorder (PTSD). We examined the association between peri-traumatic nausea and PTSD symptom development in three independent cohorts. Participants were recruited from (1) the Emergency Departments (ED) at Grady Memorial Hospital (GMH) in Atlanta, GA, (2) from multiple other ED sites in the TRYUMPH Research Network, and (3) from the ED during evaluation for suspected acute coronary syndrome in the REACH cohort. Read More

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November 2018
3 Reads

Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells.

Int J Mol Sci 2018 Nov 20;19(11). Epub 2018 Nov 20.

Oasi Research Institute-IRCCS, 94018 Troina, Italy.

Human amylin is a 37-residue peptide hormone (hA1-37) secreted by β-cells of the pancreas and, along with insulin, is directly associated with type 2 diabetes mellitus (T2DM). Amyloid deposits within the islets of the pancreas represent a hallmark of T2DM. Additionally, amylin aggregates have been found in blood vessels and/or brain of patients with Alzheimer's disease, alone or co-deposited with β-amyloid. Read More

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November 2018
3 Reads

Correction: ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations.

Neuropsychopharmacology 2018 Nov 20. Epub 2018 Nov 20.

Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA.

Following the publication of this article the authors noted an error in figure 4. In sub-panels D-F, the y-axis should read "apoE (ng/mg protein)" as opposed to "apoE (ng/ml)". The authors apologize for any inconvenience caused. Read More

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November 2018

Vortioxetine: a novel antidepressant for the treatment of major depressive disorder.

Expert Opin Drug Discov 2018 Nov 20:1-9. Epub 2018 Nov 20.

e Department of Psychiatry and Neuroscience Program, Harvard Medical School , McLean Hospital , Belmont , USA.

Introduction: Vortioxetine is a novel antidepressant drug approved for the treatment of major depressive disorder (MDD) in adults. It is formulated into tablets and has a dose range of 5-20 mg. The recommended starting dose is 10 mg administered orally once daily without the need for food. Read More

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November 2018
3 Reads

Ghrelin receptor deletion reduces binge-like alcohol drinking in rats.

J Neuroendocrinol 2018 Nov 20:e12663. Epub 2018 Nov 20.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.

Ghrelin is a gastric hormone that has been implicated in the neurobiology of alcohol drinking. We have recently developed a ghrelin receptor (GHSR) knockout (KO) rat model, which exhibits reduced food consumption and body weight. In addition, recent preliminary work suggests that the gut-microbiome, which appears to interact with the ghrelin system, may modulate alcohol drinking. Read More

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November 2018
2 Reads

Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca2.3 R-type voltage-gated calcium channel.

Data Brief 2018 Dec 24;21:1263-1266. Epub 2018 Oct 24.

Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, Germany.

This data article provides raw auditory evoked brainstem responses (ABRs) from controls and Ca2.3 transgenics, i.e. Read More

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December 2018

Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis.

Trends Pharmacol Sci 2018 Dec;39(12):995-998

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.

The United States is experiencing an epidemic of opioid overdose deaths. Many of the recent fatalities are associated with illicitly manufactured fentanyl, which is being added to heroin and counterfeit pain pills. The crisis is further exacerbated by the emergence of an increasing number of novel synthetic opioids (NSOs), including various fentanyl analogs and non-fentanyl compounds that display potent agonist actions at the μ-opioid receptor. Read More

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December 2018
4 Reads

The effects of oral smokeless tobacco administration on endurance performance.

J Sport Health Sci 2018 Oct 28;7(4):465-472. Epub 2016 Dec 28.

Neuropsychopharmacology Laboratory, Department of Diagnostic and Public Health, University of Verona, Verona 37134, Italy.

Background: Smokeless tobacco is widely used by athletes to enhance performance. Nicotine is a central nervous system stimulant and acts on cardiocirculatory and metabolic systems, involving tissue blood flow and circulatory vasoreactivity. The aim of this study was to investigate the effects of the oral smokeless tobacco (Swedish snus (SS)) on the perception of fatigue and time to exhaustion (TTE) during moderate-intensity aerobic exercise. Read More

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October 2018
1 Read

Predicting Responses to Psychedelics: A Prospective Study.

Front Pharmacol 2018 2;9:897. Epub 2018 Nov 2.

Psychedelic Research Group, Neuropsychopharmacology Unit, Centre for Psychiatry, Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom.

Responses to psychedelics are notoriously difficult to predict, yet significant work is currently underway to assess their therapeutic potential and the level of interest in psychedelics among the general public appears to be increasing. We aimed to collect prospective data in order to improve our ability to predict acute- and longer-term responses to psychedelics. Individuals who planned to take a psychedelic through their own initiative participated in an online survey (www. Read More

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November 2018
4 Reads

Killing the Buζζ: accumbal PKMζ blunts cocaine seeking and reward.

Neuropsychopharmacology 2018 Nov 18. Epub 2018 Nov 18.

Department of Neuroscience, The University of Texas at Austin, Austin, TX, 78712, USA.

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November 2018

Dopamine D receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia.

Neuropsychopharmacology 2018 Oct 26. Epub 2018 Oct 26.

Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Dopamine D receptor occupancy (DRO) is a key feature of all currently approved antipsychotic medications. However, antipsychotic efficacy associated with high DRO is often limited by side effects such as motor disturbances and hyperprolactinemia. Lumateperone (ITI-007) is a first-in-class selective and simultaneous modulator of serotonin, dopamine and glutamate in development for the treatment of schizophrenia and other disorders. Read More

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October 2018
2 Reads

[Therapeutic drug monitoring in neuropsychopharmacology : Summary of the consensus guidelines 2017 of the TDM task force of the AGNP].

Nervenarzt 2018 Nov 16. Epub 2018 Nov 16.

Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Mainz, Mainz, Deutschland.

Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood serum or plasma to optimize pharmacological therapy. TDM is an instrument with which the high interindividual variability of pharmacokinetics of patients can be identified and therefore enables a personalized pharmacotherapy. In September 2017 the TDM task force of the Working Group for Neuropsychopharmacology and Pharmacopsychiatry (AGNP) published an update of the consensus guidelines on TDM published in 2011. Read More

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November 2018

Dopamine restores limbic memory loss, dendritic spine structure and NMDAR-dependent LTD in the nucleus accumbens of alcohol-withdrawn rats.

J Neurosci 2018 Nov 16. Epub 2018 Nov 16.

University of Sassari, 'G.Minardi' Laboratory of Cognitive Neuroscience, Department of Chemistry and Pharmacy Via Muroni, 23 07100 Sassari, Italy.

Alcohol abuse leads to aberrant forms of emotionally salient memory - i.e. limbic memory - that promote escalated alcohol consumption and relapse. Read More

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November 2018
9 Reads

Prediction of remission in pharmacotherapy of untreated major depression: development and validation of multivariable prediction models.

Psychol Med 2018 Nov 15:1-9. Epub 2018 Nov 15.

Department of Neuropsychopharmacology,National Center of Neurology and Psychiatry,Tokyo,Japan.

Background: Depression is increasingly recognized as a chronic and relapsing disorder. However, an important minority of patients who start treatment for their major depressive episode recover to euthymia. It is clinically important to be able to predict such individuals. Read More

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November 2018
2 Reads

Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition.

Neuropsychopharmacology 2018 Nov 12. Epub 2018 Nov 12.

Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON, M5S 3G3, Canada.

The monoamine neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts an inhibitory influence over motivation, but the circuits mediating this are unknown. Here, we used an optogenetic approach to isolate the contribution of dorsal raphe nucleus (DRN) 5-HT neurons and 5-HT innervation of the mesolimbic dopamine (DA) system to motivated behavior in mice. We found that optogenetic stimulation of DRN 5-HT neurons enhanced downstream 5-HT release, but this was not sufficient to inhibit operant responding for saccharin, a measure of motivated behavior. Read More

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November 2018
3 Reads

Response dynamics of midbrain dopamine neurons and serotonin neurons to heroin, nicotine, cocaine, and MDMA.

Cell Discov 2018 6;4:60. Epub 2018 Nov 6.

3National Institute of Biological Sciences (NIBS), Beijing, 102206 China.

Heroin, nicotine, cocaine, and MDMA are abused by billions of people. They are believed to target midbrain dopamine neurons and/or serotonin neurons, but their effects on the dynamic neuronal activity remain unclear in behaving states. By combining cell-type-specific fiber photometry of Ca signals and intravenous drug infusion, here we show that these four drugs of abuse profoundly modulate the activity of mouse midbrain dopamine neurons and serotonin neurons with distinct potency and kinetics. Read More

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November 2018
3 Reads

Baclofen for the treatment of alcohol use disorder: the Cagliari Statement.

Lancet Psychiatry 2018 Dec 6;5(12):957-960. Epub 2018 Nov 6.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, RI, USA.

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December 2018
8 Reads

Baclofen and alcohol in France - Authors' reply.

Lancet Psychiatry 2018 Dec 6;5(12):962-963. Epub 2018 Nov 6.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, RI, USA.

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December 2018
6 Reads

Intrinsic functional connectivity correlates of person-level risk for bipolar disorder in offspring of affected parents.

Neuropsychopharmacology 2018 Nov 8. Epub 2018 Nov 8.

University of Pittsburgh, 3811O Hara St, Pittsburgh, PA, 15213, USA.

Offspring of parents with bipolar disorder (OBP) are at increased risk to develop bipolar disorder (BD). Alterations in resting-state functional connectivity (rsFC) have been identified in OBP; however, replication has been limited and correlation with person-level risk is unknown. A recent study found reduced rsFC between left inferior frontal gyrus (IFG) and clusters in the left insula (LINS), lentiform nucleus (LENT), and midcingulate cortex (MCING) in OBP (Roberts et al. Read More

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November 2018
12 Reads

Ayahuasca improves emotion dysregulation in a community sample and in individuals with borderline-like traits.

Psychopharmacology (Berl) 2018 Nov 7. Epub 2018 Nov 7.

Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Barcelona, Spain.

Background: Research suggests that mindfulness-based interventions may improve mindfulness-related capacities (e.g., decentering, non-judging, and non-reacting) and emotion regulation. Read More

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November 2018
3 Reads

mRNA Expression in Peripheral Blood Lymphocytes in Drug Addicted Patients.

Front Pharmacol 2018 24;9:1205. Epub 2018 Oct 24.

Laboratory of Cognitive Sciences and Neuropsychopharmacology, Program of Post-Graduation in Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.

gene heterodimerizes with Jun family proteins to form activator protein 1 (AP-1) complexes that bind to AP-1 sites in responsive genes to regulate transcription in all cells. The genic expression of seems to be modified after long time exposure to drugs of abuse and these changes may be involved in craving and addicted behavior. This study investigated the mRNA expression in peripheral blood lymphocytes of drug addicted patients using real-time PCR approach. Read More

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October 2018
3 Reads

Lack of Effects of Extended Sessions of Transcranial Direct Current Stimulation (tDCS) Over Dorsolateral Prefrontal Cortex on Craving and Relapses in Crack-Cocaine Users.

Front Pharmacol 2018 23;9:1198. Epub 2018 Oct 23.

Laboratory of Cognitive Sciences and Neuropsychopharmacology, Program of Post-Graduation in Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.

Non-invasive brain stimulation such as transcranial direct current stimulation (tDCS) has been investigated as additional therapeutic tool for drug use disorder. In a previous study, we showed that five sessions of tDCS applied bilaterally over the dorsolateral prefrontal cortex (dlPFC) reduced craving to the use of crack-cocaine in inpatients from a specialized clinic. In the present study, we examine if an extended number of sessions of the same intervention would reduce craving even further and affect also relapses to crack-cocaine use. Read More

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October 2018
3 Reads

Intermittent intake of rapid cocaine injections promotes the risk of relapse and increases mesocorticolimbic BDNF levels during abstinence.

Neuropsychopharmacology 2018 Oct 26. Epub 2018 Oct 26.

Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, QC, H3C 3J7, Canada.

Cocaine is thought to be more addictive when it reaches the brain rapidly. We predicted that variation in the speed of cocaine delivery influences the likelihood of addiction in part by determining the risk of relapse after abstinence. Under an intermittent-access schedule, rats pressed a lever for rapid (injected over 5 s) or slower (90 s) intravenous cocaine injections (0. Read More

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October 2018
3 Reads