13,328 results match your criteria Neuropsychological Evaluation


Neuropsychological profile associated with an alpha-synuclein gene () duplication.

Clin Neuropsychol 2021 May 13:1-12. Epub 2021 May 13.

Section of Neurobehavioral Health, Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

The alpha-synuclein gene () is implicated in both Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The purpose of this case study was to describe the neuropsychological profile, clinical trajectory, and treatment course of an individual with a known gene duplication who was followed over the course of three years. The patient was a healthy man who developed olfactory changes in early adulthood followed by parkinsonism and cognitive concerns around age 40. Read More

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Methylphenidate treatment for cognitive symptoms associated with ADHD in a pediatric epilepsy patient following resection of a left frontal cortical dysplasia.

Epilepsy Behav Rep 2021 10;16:100435. Epub 2021 Feb 10.

Center for Rare Neurological Diseases, Atlanta, GA, USA.

We present data on a 10-year-old patient with drug-resistant epilepsy who was treated with methylphenidate for symptoms of attention deficit hyperactivity disorder (ADHD) that developed after she underwent surgical resection of a left frontal cortical dysplasia. . The patient's parents reported methylphenidate was helpful in improving their child's reading performance. Read More

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February 2021

Specific abnormalities in white matter pathways as interface to small vessels disease and cognition in CADASIL individuals.

Brain Connect 2021 May 12. Epub 2021 May 12.

Harvard Medical School, 1811, Psychiatry and Neurology, 100 1st Avenue, suite 101, Charlestown, Boston, Massachusetts, United States, 02129;

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by leukoencephalopathy leading to cognitive impairment. Subtle cognitive deficits can be observed early in the course of the disease, prior to the occurrence of the first stroke. Therefore, markers that can predict disease progression at this early stage, when interventions are likely to alter disease course, are needed. Read More

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Psychiatric and cognitive characteristics of older adults admitted to a Video-EEG monitoring (VEM) unit.

Epilepsy Behav 2021 May 9;120:107987. Epub 2021 May 9.

Department of Medicine (RMH), The University of Melbourne, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Australia; Melbourne School of Psychological Sciences, The University of Melbourne, Australia.

Objective: To compare the clinical, psychiatric, and cognitive characteristics of older with younger patients presenting to a video-EEG monitoring (VEM) unit.

Method: This was a retrospective case-control study involving patients admitted for VEM over a two-year period (from April 2018 to April 2020) at two comprehensive epilepsy units. Patients were categorized into an older (≥60 years) and a younger (<60 years) group. Read More

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Associations of cognitive reserve and psychological resilience with cognitive functioning in subjects with cerebral white matter hyperintensities.

Eur J Neurol 2021 May 11. Epub 2021 May 11.

HUS Neurocenter, Division of Neuropsychology, Helsinki University Hospital, University of Helsinki.

Background And Purpose: Cerebral small vessel disease is characterised by progressive white matter hyperintensities (WMH) and cognitive decline. However, variability exists in how individuals maintain cognitive capabilities despite significant neuropathology. We examined the relationships between individual cognitive reserve, psychological resilience and cognitive functioning in subjects with varying degrees of WMH. Read More

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The clinical utility of a memory specialization index in epilepsy surgery patients with unilateral hippocampal sclerosis.

Epilepsia 2021 May 10. Epub 2021 May 10.

University College Hospital, London, UK.

Objective: Although group studies provide some support for the material-specific model of memory function, there are considerable individual variations in memory function in people with temporal lobe epilepsy, even in those with the same underlying pathology. In this proof-of-concept study, we examined the sensitivity and specificity of a single measure of an individual's relative strength for the encoding of verbal or visual learning.

Methods: Six hundred ninety-two patients with left hemisphere language dominance and unilateral hippocampal sclerosis completed verbal and visual encoding tasks with similar test structures as part of their presurgical evaluation. Read More

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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions.

J Vis Exp 2021 Apr 23(170). Epub 2021 Apr 23.

Department of Medicine, The University of Hong Kong; Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong;

Evidence accumulated from the last decade has proven that silent cerebrovascular lesions (SCLs) and their underlying pathogenic processes contribute to cognitive decline in the elderly. However, the distinct effects of each type of the lesions on cognitive performance remain unclear. Moreover, research data from Chinese elderly with SCLs is scarce. Read More

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Assessment of Affective-Behavioral States in Parkinson's Disease Patients: Toward a New Screening Tool.

J Parkinsons Dis 2021 May 3. Epub 2021 May 3.

Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: Assessment of affective-behavioral states in patients with Parkinson's disease (PD) undergoing deep brain stimulation (DBS) is essential.

Objective: To analyze well-established questionnaires as a pilot-study with the long term aim to develop a screening tool evaluating affective-behavioral dysfunction, including depression, anxiety, apathy, mania, and impulse control disorders, in PD patients screened for DBS.

Methods: Two hundred ninety-seven inpatients with PD underwent standardized neuropsychiatric testing including German versions of Beck Depression Inventory-II, Hospital Anxiety and Depression Scale, Apathy Evaluation Scale, Self-Report Manic Inventory, and Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale, to assess appropriateness for DBS. Read More

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Long-Term Outcomes of Patients with Hydrocephalus Secondary to Tectal Plate Glioma versus Idiopathic Aqueductal Stenosis: Results from a Single Center.

Pediatr Neurosurg 2021 May 7:1-11. Epub 2021 May 7.

Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.

Introduction: Tectal plate gliomas (TPG) constitute a distinct entity of benign tumors of the brain stem which show an indolent clinical course. Adequate treatment of secondary hydrocephalus is undoubtedly a major factor in the outcome. However, little is known about to what degree the tumor itself determines the long-term outcome of these patients. Read More

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Validation of the Finnish version of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and evaluation of the applicability of the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) and the Fatigue Scale for Motor and Cognitive Functions (FSMC).

Brain Behav 2021 May 7:e02087. Epub 2021 May 7.

Masku Neurological Rehabilitation Centre, The Finnish Neuro Society, Masku, Finland.

Objectives: Cognitive impairment is frequent in multiple sclerosis (MS) as approximately half of the patients manifest some degree of cognitive impairment. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) has been designed for brief cognitive evaluation. The purpose of the study was to validate the BICAMS along with the Finnish versions of one self-rating questionnaire each for cognition and fatigue. Read More

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Neurocognitive and Behavioral Outcomes of Chinese Survivors of Childhood Lymphoblastic Leukemia.

Front Oncol 2021 20;11:655669. Epub 2021 Apr 20.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Background: Increasing attention has been dedicated to investigate modifiable risk factors of late effects in survivors of childhood cancer. This study aims to evaluate neurocognitive and behavioral functioning in a relatively young cohort of survivors of childhood acute lymphoblastic leukemia (ALL) in Hong Kong, and to identify clinical and socio-environmental factors associated with these outcomes.

Methods: This analysis included 152 survivors of childhood ALL who were ≥5 years post-diagnosis (52% male, mean [SD] age 23. Read More

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"Do I Have a Memory Problem? I Can't Recall": An Evaluation of Measurement Invariance in Subjective Reporting of Memory Symptoms among Persons with and without Objective HIV-Associated Memory Impairment.

J Int Neuropsychol Soc 2021 May 6:1-11. Epub 2021 May 6.

Department of Psychology, University of Houston, Houston, USA.

Objective: Memory symptoms and objective impairment are common in HIV disease and are associated with disability. A paradoxical issue is that objective episodic memory failures can interfere with accurate recall of memory symptoms. The present study assessed whether responses on a self-report scale of memory symptoms demonstrate measurement invariance in persons with and without objective HIV-associated memory impairment. Read More

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Factors associated with utilization of emotion and personality instruments among neuropsychologists.

Appl Neuropsychol Adult 2020 Dec 2:1-10. Epub 2020 Dec 2.

Department of Clinical Psychology, The Chicago School of Professional Psychology - Washington DC Campus, Washington, USA.

Historically, assessment of emotion and personality functioning was not emphasized by clinical neuropsychologists, who instead focused almost exclusively on the evaluation of cognitive functioning. This study examined current practices regarding clinical neuropsychologists' usage of instruments for assessing emotion and personality, along with factors that may mediate their choice of measures and their beliefs about evaluating emotion and personality. Participants were 117 board-certified neuropsychologists as recognized by the American Board of Professional Psychology (ABPP-CN), many of whom had been practicing for over 20 years (39%). Read More

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December 2020

Motor and cognitive outcomes of cerebello-spinal stimulation in neurodegenerative ataxia.

Brain 2021 May 5. Epub 2021 May 5.

Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Cerebellar ataxias represent a heterogeneous group of disabling disorders characterized by motor and cognitive disturbances, for which no effective treatment is currently available. In this randomized, double-blind, sham-controlled trial, followed by an open-label phase, we investigated whether treatment with cerebello-spinal transcranial direct current stimulation (tDCS) could improve both motor and cognitive symptoms in patients with neurodegenerative ataxia at short and long-term. Sixty-one patients were randomized in two groups for the first controlled phase. Read More

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Effectiveness of a Visual Imagery Training Program to Improve Prospective Memory in Older Adults with and without Mild Cognitive Impairment: A Randomized Controlled Study.

Neuropsychol Rehabil 2021 May 4:1-29. Epub 2021 May 4.

Department of Psychology, Université du Québec à Montréal, Montreal, Canada.

Prospective memory (PM) problems in aging and, to a greater extent, in mild cognitive impairment (MCI), compromise functional independence. This study examined the effectiveness of a cognitive training program based on visual imagery to improve PM among older adults with and without MCI. Participants were older adults, 24 with MCI and 24 cognitively healthy (HOA). Read More

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Neuropsychological Profile, Emotional/Behavioral Problems, and Parental Stress in Children with Neurodevelopmental Disorders.

Brain Sci 2021 Apr 30;11(5). Epub 2021 Apr 30.

Child Neuropsychiatry Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Fisciano, Italy.

Background: The aim of our study was to trace a specific neuropsychological profile, to investigate emotional-behavioral problems and parental stress in children with Autism Spectrum Disorder Level 1/High functioning (ASD-HF), Specific Learning Disorders (SLD) and Attention Deficit/Hyperactivity Disorder (ADHD) disorders and to highlight similarities and differences among the three groups.

Methods: We retrospectively collected the data from a total of 62 subjects with ASD-HF ( = 19) ADHD ( = 21), SLD ( = 22) and 20 typical development. All the participants underwent neuropsychological standardized test for the evaluation of cognitive profile (Wechsler Intelligence Scale for Children Fourth Edition-WISC-IV), behavioral and emotional problems (Child Behavior CheckList CBCL), and parental stress (Parental Stress Index Short Form-PSI-SF). Read More

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Neuropsychological surveillance model for survivors of pediatric cancer: A descriptive report of methodology and feasibility.

Clin Neuropsychol 2021 May 3:1-22. Epub 2021 May 3.

Cancer and Blood Disease Institute, Division of Hematology, Oncology, and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Neuropsychological late effects of pediatric cancer may not become apparent for years after therapy; therefore, serial monitoring is necessary for detecting changes to ensure timely intervention. Unfortunately, lack of access to neuropsychologists, increased patient volume, insurance authorization and reimbursement issues, time required for neuropsychological evaluation, and practice effects related to repeat testing present many challenges to provision of neuropsychological care for survivors of childhood cancer. Models involving surveillance and monitoring have been proposed, though minimal data exist related to the implementation and feasibility of such models. Read More

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Possibility of Using Quantitative Assessment with the Cube Copying Test for Evaluation of Visuo-spatial Function in Patients with Alzheimer's Disease.

Prog Rehabil Med 2021 29;6:20210021. Epub 2021 Apr 29.

Department of Rehabilitation Medicine I, School of Medicine, Fujita Health University, Toyoake, Japan.

Objectives: The aim of this study was to investigate the clinical usefulness of the Cube Copying Test (CCT) for quantitative assessment of visuo-spatial function in patients with Alzheimer's disease (AD).

Methods: The CCT, Raven's Colored Progressive Matrices (RCPM), and other neuropsychological tests were administered to 152 AD outpatients. For the quantitative assessment of CCT, we scored the points of connection (POC) and the number of plane-drawing errors (PDE) and categorized the pattern classification (PAC). Read More

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Investigating Neuroimaging Correlates of Early Frailty in Patients With Behavioral Variant Frontotemporal Dementia: A MRI and FDG-PET Study.

Front Aging Neurosci 2021 14;13:637796. Epub 2021 Apr 14.

Centro Interdipartimentale di Studi Avanzati in Neuroscienze - National Institute of Turin (NIT), Orbassano, Italy.

Frailty is a dynamic clinical condition characterized by the reduction of interconnections among different psychobiological domains, which leads to a homeostatic vulnerability. The association between physical frailty and cognitive dysfunctions is a possible predictor of poor prognosis in patients with neurodegenerative disorders. However, this construct has not been fully analyzed by a multidimensional neuropsychogeriatric assessment matched with multimodal neuroimaging methods in patients with behavioral variant frontotemporal dementia (bvFTD). Read More

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Preoperative medication use and development of postoperative delirium and cognitive dysfunction.

Clin Transl Sci 2021 May 2. Epub 2021 May 2.

Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Postoperative delirium (POD) and postoperative (neuro-)cognitive disorder (POCD) are frequent and serious complications after operations. We aim to investigate the association between pre-operative polypharmacy and potentially inappropriate medications and the development of POD/POCD in elderly patients. This investigation is part of the European BioCog project (www. Read More

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Neurological and cognitive sequelae of Covid-19: a four month follow-up.

J Neurol 2021 May 1. Epub 2021 May 1.

Unit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.

Central and peripheral nervous system involvement during acute COVID-19 is well known. Although many patients report some subjective symptoms months after the infection, the exact incidence of neurological and cognitive sequelae of COVID-19 remains to be determined. The aim of this study is to investigate if objective neurological or cognitive impairment is detectable four months after SARS-CoV-2 infection, in a group of patients who had mild-moderate COVID-19. Read More

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Predicting occupational outcomes from neuropsychological test performance in older people with HIV.

AIDS 2021 Apr 28. Epub 2021 Apr 28.

Department of Psychiatry, McGill University, Montreal, Canada Chronic Viral Illness Service, McGill University Health Centre (MUHC), Montreal, Canada Infectious Diseases and Immunity in Global Health Program, MUHC-RI, Montreal, Canada Canadian Institutes of Health Research Canadian HIV Trials Network, Vancouver, BC, Canada Department of Psychology, McGill University, Montreal, Canada Clinique NeuroÉvolution Bachelor of Behavioral Neuroscience, Concordia University, Montreal, CANADA Departments of Neurology and HIV Medicine, St Vincent's Hospital and Peter Duncan Neurosciences Unit, Sydney, Australia Faculty of Medicine, University of Notre Dame, and Faculty of Medicine, University of New South Wales, Sydney, Australia Department of Neurology and Neurosurgery, McGill University, Montreal, Canada Montreal Neurological Hospital and Institute, McGill University, Montreal, Canada Department of Medicine, School of Physical and Occupational Therapy, McGill University, Montreal, Canada Division of Clinical Epidemiology, McGill University Health Centre (MUHC), Center for Outcomes Research and Evaluation, Montreal, Canada Division of Geriatrics, McGill University Health Centre (MUHC), Montreal, Canada School of Psychology, University of New South Wales, Australia.

Objective: The ability to work is amongst the top concerns of people living with welltreated HIV. Cognitive impairment has been reported in many otherwise asymptomatic persons living with HIV and even mild impairment is associated with higher rates of occupational difficulties. There are several classification algorithms for HIV-Associated Neurocognitive Disorder (HAND) as well as overall scoring methods available to summarize neuropsychological performance. Read More

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The future is now: pediatric neuropsychological presurgical epilepsy evaluation in the age of COVID-19.

Epileptic Disord 2021 Apr 29. Epub 2021 Apr 29.

Department of Neurology, University of Texas Health Austin Pediatric Neurosciences at Dell Children's, Austin, Texas, USA.

The objective of this brief report is to review an assessment paradigm for conducting virtual neuropsychological pre-surgical evaluations in the context of the COVID-19 pandemic. A multidisciplinary epilepsy team at a Level 4 epilepsy center within a large children's academic medical center convened to discuss the challenges and possible solutions for Phase II evaluations for pediatric patients with pharmacoresistant epilepsy during the COVID-19 pandemic. The neuropsychologists explored evidence-based methods of virtual evaluation and developed a systematic decision-making process for youth requiring a Phase II evaluation. Read More

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Movement Patterns in Students Diagnosed with ADHD, Objective Measurement in a Natural Learning Environment.

Int J Environ Res Public Health 2021 Apr 7;18(8). Epub 2021 Apr 7.

Department of Architectural Constructions, University of Alicante, 03690 Alicante, Spain.

Attention deficit hyperactivity disorder is the most common neuropsychological disorder in childhood and adolescence, affecting the basic psychological processes involved in learning, social adaptation and affective adjustment. From previous research, the disorder is linked to problems in different areas of development, with deficiencies in psychological processes leading to the development of the most common characteristics of the disorder such as inattention, excess of activity and lack of inhibitory control. As for the diagnosis, in spite of being a very frequent disorder, there are multiple controversies about which tools are the most suitable for evaluation. Read More

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Lifestyle Factors, Cognitive Functioning, and Functional Capacity in Older Adults.

Int J Aging Hum Dev 2021 Apr 29:914150211009467. Epub 2021 Apr 29.

8212 Regent University, Virginia Beach, VA, USA.

Research suggests that clinical management of cognitive impairment can occur through interventions targeting lifestyle factors, such as physical exercise and sleep quality. The present study examined the associations among lifestyle factors (exercise and sleep quality), cognition, and functional capacity in older adults (ages 56-94) who completed an outpatient neuropsychological evaluation ( = 356). Exercise habits and sleep quality were accessed using a self-report questionnaire and a clinical interview. Read More

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A Simple and Effective Way to Study Executive Functions by Using 360° Videos.

Front Neurosci 2021 12;15:622095. Epub 2021 Apr 12.

Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.

Executive dysfunctions constitute a significant public health problem due to their high impact on everyday life and personal independence. Therefore, the identification of early strategies to assess and rehabilitate these impairments appears to be a priority. The ecological limitations of traditional neuropsychological tests and the numerous difficulties in administering tests in real-life scenarios have led to the increasing use of virtual reality (VR) and 360° environment-based tools for assessing executive functions (EFs) in real life. Read More

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Inflammatory Markers May Inform the Effects of Electroconvulsive Therapy on Cognition in Patients with Depression.

Neuropsychobiology 2021 Apr 28:1-9. Epub 2021 Apr 28.

Department of Psychiatry, University Psychiatric Center Duffel, Duffel, Belgium.

Introduction: The neurobiological mechanisms underlying the acute cognitive effects of electroconvulsive therapy (ECT) remain poorly understood. Prior research has shown that proinflammatory cytokines such as IL-6, TNF-α, IL1-β, and IL-10 may interfere with cognitive functioning. Interestingly, immunomodulation is one of the proposed modes of action of ECT. Read More

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[Effect of combination of acupuncture and psychological intervention on attention, response inhibition and cerebral blood flow in children with attention deficit hyperactivity disorder].

Zhongguo Zhen Jiu 2021 Apr;41(4):400-4

Department of Pediatrics, Qingzhou Municipal Chinese Medicine Hospital of Shandong Province.

Objective: To observe the clinical curative effect on attention deficit hyperactivity disorder (ADHD) and explore the relevant mechanism of acupuncture in treatment.

Methods: A total of 100 ADHD children were randomized into an observation group (50 cases, 2 cases dropped off) and a control group (50 cases, 1 case dropped off). In the control group, the routine psychological intervention was used. Read More

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Evaluation of the Implementation and Effectiveness of Community-Based Brain-Computer Interface Cognitive Group Training in Healthy Community-Dwelling Older Adults: Randomized Controlled Implementation Trial.

JMIR Form Res 2021 Apr 27;5(4):e25462. Epub 2021 Apr 27.

Geriatric Education and Research Institute, Singapore, Singapore.

Background: Cognitive training can improve cognition in healthy older adults.

Objective: The objectives are to evaluate the implementation of community-based computerized cognitive training (CCT) and its effectiveness on cognition, gait, and balance in healthy older adults.

Methods: A single-blind randomized controlled trial with baseline and follow-up assessments was conducted at two community centers in Singapore. Read More

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Predictors of Function, Activity, and Participation of Stroke Patients Undergoing Intensive Rehabilitation: A Multicenter Prospective Observational Study Protocol.

Front Neurol 2021 8;12:632672. Epub 2021 Apr 8.

IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.

The complex nature of stroke sequelae, the heterogeneity in rehabilitation pathways, and the lack of validated prediction models of rehabilitation outcomes challenge stroke rehabilitation quality assessment and clinical research. An integrated care pathway (ICP), defining a reproducible rehabilitation assessment and process, may provide a structured frame within investigated outcomes and individual predictors of response to treatment, including neurophysiological and neurogenetic biomarkers. Predictors may differ for different interventions, suggesting clues to personalize and optimize rehabilitation. Read More

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