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Arch Clin Neuropsychol 2022 May 22. Epub 2022 May 22.

Neuropsychology Service, Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Objective: Attention, inhibition, and processing speed are related to functional decline among older adults. This study attempts to clarify the relationships between these cognitive factors and adaptive functioning.

Method: We examined relationships between attention, inhibition, and processing speed, with scores on the Texas Functional Living Scale (TFLS), a performance-based measure of daily functioning, in a mixed clinical sample of 530 older adults who were referred for an outpatient neuropsychological evaluation. Read More

Appl Neuropsychol Adult 2022 May 20:1-8. Epub 2022 May 20.

Athens Alzheimer's Association, Athens, Greece.

The use of technological means in the process of neuropsychological assessment has been proposed as a technique with promising results in the field of detection of neurocognitive disorders for community-dwelling older adults. Especially during the pandemic period due to COVID-19, telemedicine assumed to be vital in the field of early diagnosis of cognitive disorders and highlighted the clinical utility of remote methods of neuropsychological assessmentby video-conference. This descriptive study presents the development of a remote neuropsychological assessment protocol by selecting appropriate validated tests as part of a more comprehensive evaluation for older adults dwelling in the community. Read More

J Neurosurg Pediatr 2022 May 20:1-12. Epub 2022 May 20.

1Service de Neurochirurgie, Hôpital universitaire Necker, AP-HP, Paris, France.

Objective: The aim of this study was to determine the cognitive profile of children with a temporal arachnoid cyst (TAC) and its impact on daily life.

Methods: The authors prospectively analyzed the cognitive and psychological profiles of 100 consecutive children relative to age and cyst characteristics (side, cyst size, and cyst shape: convex or nonconvex) and their outcome 4 years later.

Results: Mean IQs were normal but with high heterogeneity on Full Scale IQ (FSIQ; range 59-150); 29% of children had at least one Wechsler index below the norm, in particular, Processing Speed and Working Memory Indexes. Read More

Front Artif Intell 2022 3;5:787179. Epub 2022 May 3.

German Research Center for Artificial Intelligence (DFKI), Saarland Informatics Campus, Saarbrücken, Germany.

Digital pen features model characteristics of sketches and user behavior, and can be used for various supervised machine learning (ML) applications, such as multi-stroke sketch recognition and user modeling. In this work, we use a state-of-the-art set of more than 170 digital pen features, which we implement and make publicly available. The feature set is evaluated in the use case of analyzing paper-pencil-based neurocognitive assessments in the medical domain. Read More

Cereb Cortex 2022 May 19. Epub 2022 May 19.

National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, #1 Keyuan Road 4, Gaopeng Street, High-tech Development Zone, Chengdu 610041, China.

Sevoflurane exposure in the neonatal period causes long-term developmental neuropsychological dysfunction, including memory impairment and anxiety-like behaviors. However, the molecular mechanisms underlying such effects have not been fully elucidated. In this study, we investigated the effect of neonatal exposure to sevoflurane on neurobehavioral profiles in adolescent rats, and applied an integrated approach of lipidomics and proteomics to investigate the molecular network implicated in neurobehavioral dysfunction. Read More

Ann Clin Transl Neurol 2022 May 18. Epub 2022 May 18.

Department of Biomedical and NeuroMotor Sciences (DIBINEM), Alma Mater Studiorum - University of Bologna, Bologna, Italy.

Objective: To disclose the nature of cognitive deficits in a cohort of patients with idiopathic autonomic failure (IAF) by exploring the relation among cognitive functions, cardiovascular autonomic failure (AF) and clinical progression to another α-synucleinopathy (phenoconversion).

Methods: We retrospectively identified all patients with a clinical diagnosis of IAF who underwent a comprehensive neuropsychological evaluation, clinical examination and cardiovascular autonomic tests from the IAF-BO cohort. Brain magnetic resonance imaging (MRI) studies and cerebrospinal fluid (CSF) analysis, including neurofilament light chain (NfL), Alzheimer disease core biomarkers, and α-synuclein seeding activity were further evaluated when available. Read More

Neurol Sci 2022 May 17. Epub 2022 May 17.

Department of Psychology, University of Milano Bicocca, Piazza dell'ateneo nuovo 1, Milan, Italy.

Introduction: Neuropsychological assessment of cognitive functioning is a crucial part of clinical care: diagnosis, treatment planning, treatment evaluation, research, and prediction of long-term outcomes. The Equivalent Score (ES) method is used to score numerous neuropsychological tests. The ES0 and the ES4 are defined respectively by the outer tolerance limit and the median. Read More

Sci Rep 2022 May 17;12(1):8202. Epub 2022 May 17.

Department of Rehabilitation and Physical Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Cognitive frailty (CF) is a clinical condition defined by the presence of both mild cognitive impairment (MCI) and physical frailty (PF). Elderly with CF are at greater risk of dementia than those with MCI or PF alone, but there are few known clinical or neuroimaging features to reliably distinguish CF from PF or MCI. We therefore conducted a population-based cross-sectional study of community elderly combining physical, cognitive, neuropsychiatric, and multisequence magnetic resonance imaging (MRI) evaluations. Read More

Qual Life Res 2022 May 17. Epub 2022 May 17.

Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, UK.

Background: Cognitive impairment (CI) in people living with HIV (PLWH) is an important health concern in the context of an ageing HIV population. Impacting 14-28% of PLWH, CI is associated with lower health-related quality of life (HRQoL), however, evaluation of the illness-specific factors comprising HRQoL in PLWH with CI have not been assessed.

Objective: We sought to contribute evidence toward an understanding of HRQoL and identify domains of HRQoL in PLWH with CI. Read More

CNS Neurol Disord Drug Targets 2022 May 16. Epub 2022 May 16.

Clinical Neuroscience Laboratory, Faculty of Medicine of Fez; Fez, Morocco.

Objective: The aim of this paper is to demonstrate the impact of heavy and chronic cannabis use on brain potential functional control, reorganization, and plasticity in the cortical area.

Methods: 23 cannabis users were convened in 3 user's groups. The first group included 11 volunteers with an average of 15 joins/day; the second group included 6 volunteers with an average of 1. Read More

J Neuropsychiatry Clin Neurosci 2022 May 17:appineuropsych21040091. Epub 2022 May 17.

Department of Mental Health & Behavioral Sciences, James A. Haley Veterans' Hospital, Tampa, Florida.

Objectives: The study compared the accuracy of the Mini-Mental State Examination (MMSE) with its modified version (3MS) in distinguishing healthy older adults from adults with cognitive impairment due to suspected Alzheimer's disease (AD) or vascular disease (VaD).

Method: Participants were 98 veterans who underwent comprehensive neuropsychological evaluation due to concern for cognitive decline. Participants were selected via retrospective chart review on the basis of diagnosis. Read More

Sci Rep 2022 May 16;12(1):8024. Epub 2022 May 16.

Functional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Turkey.

There are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients with Parkinson's Disease (PD). The purpose of this study was to investigate the synergistic therapeutic effects of Virtual Reality based EG on motor and cognitive symptoms in PD and its possible effects on neuroplasticity. Eligible patients with the diagnosis of PD were randomly assigned to one of the two study groups: (1) an experimental EG group, (2) an active control Exercise Therapy (ET) group. Read More

Mult Scler Relat Disord 2022 Apr 30;63:103837. Epub 2022 Apr 30.

Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, University of Edinburgh, Edinburgh, UK; Centre for Clinical Brain Sciences, Chancellor's Building, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neurone Disease Research, Chancellor's Building, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at University of Edinburgh, Chancellor's Building, Edinburgh, UK. Electronic address:

Background: In addition to motor disability, "hidden disability" such as depression, anxiety, fatigue, sleep disturbance, cognitive impairment and pain is a major complaint of people with multiple sclerosis. We explored changes in hidden disability burden in the early post-diagnostic period and examined the hypothesis that disease modifying therapies have a beneficial effect on hidden disability burden.

Methods: Adults with recently diagnosed (< 6 months) relapsing-remitting multiple sclerosis (n = 440, mean age 37. Read More

J Nutr 2022 May 16. Epub 2022 May 16.

Centre de recherche du CHU de Québec-Université Laval, VITAM-Centre de recherche en santé durable, CIUSSS-Capitale Nationale and Institut sur le vieillissement et la participation sociale des aînés, Quebec, Canada.

Background: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are suggested to play a role in the prevention of cognitive decline. The evidence may be inconsistent due to methodological issues including interrelations with other long-chain (14 or more carbons) fatty acids (LCFAs) and use of sex as a confounding factor rather than an effect modifier.

Objective: This study evaluated the association between serum n-3 PUFAs and performance across four cognitive domains, overall and by sex, while controlling for other LCFAs. Read More

Paediatr Perinat Epidemiol 2022 May 16. Epub 2022 May 16.

Division of Public Health, Department of Pediatrics and Human Development, Michigan State University and Hurley Children's Hospital Pediatric Public Health Initiative, Flint, Michigan, USA.

Background: Children in Flint, Michigan, have multiple risk factors for behavioural challenges, including exposure to lead during the Flint water crisis. However, their behavioural health status is largely unknown. Robust data from the Flint Registry can help understand the burden of behavioural outcomes and inform the allocation of resources. Read More

Int J Environ Res Public Health 2022 May 9;19(9). Epub 2022 May 9.

Departamento de Ciências do Comportamento, ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua Jorge de Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

An early, extensive, accurate, and cost-effective clinical diagnosis of neurocognitive disorders will have advantages for older people and their families, but also for the health and care systems sustainability and performance. BRAINCODE is a technology that assesses cognitive impairment in older people, differentiating normal from pathologic brain condition, based in an EEG biomarkers evaluation. This paper will address BRAINCODE's pilot design, which intends to validate its efficacy, to provide guidelines for future studies and to allow its integration on the SHAPES platform. Read More

BMC Womens Health 2022 May 10;22(1):149. Epub 2022 May 10.

Department of Nursing, Chang Gung Memorial Hospital, Linkou, Taoyuan City, 33303, Taiwan, ROC.

Background: The perimenopausal period is associated with a higher risk of various mood disorders. Similarly, although resting-state electroencephalogram (rsEEG) brain oscillatory activity has been associated with various neuropsychological disorders and behaviours, these issues have not been assessed in perimenopausal women. This study aimed to evaluate quantitative relationships between psychometric properties and rsEEG rhythms (delta, theta, alpha, beta and gamma powers) in perimenopausal women. Read More

Nicotine Tob Res 2022 May 10. Epub 2022 May 10.

Université de Nantes, Univ Angers, Laboratoire de Psychologie des Pays de la Loire, LPPL, EA 4638, Nantes, France.

Introduction: The exploration of cognitive impairments associated with tobacco use disorder has expanded during the last decades, centrally showing working memory and executive deficits among smokers. Despite their critical role in everyday life and in the smoking cessation process, attentional abilities have seldom been explored. Previous studies yielded discordant results, and the involvement of attentional deficits in smoking habits remains unclear. Read More

Telemed J E Health 2022 May 9. Epub 2022 May 9.

Neuropsychological Therapy Centre (NTC), Faculty of Psychology, Ruhr University Bochum, Bochum, Germany.

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Epilepsy Behav 2022 Jun 5;131(Pt A):108709. Epub 2022 May 5.

Neuropsychology, Epilepsia Helsinki, University of Helsinki and Helsinki University Hospital, Finland.

Objectives: Previous studies have shown that younger age, higher education, and seizure freedom after epilepsy surgery are associated with employment. However, very few studies have investigated associations with cognition and employment status in epilepsy surgery patients.

Methods: This retrospective study consists of 46 adult patients, who underwent resective epilepsy surgery in the Helsinki University Hospital between 2010 and 2018 and who had been assessed by a neuropsychologist prior to surgery and 6 months after surgery using a systematic test battery. Read More

Value Health 2022 May 4. Epub 2022 May 4.

Trinity College Institute for Neuroscience, Trinity College Dublin, Dublin, Ireland; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland; School of Medicine, Dentistry and Biomedical Sciences, University of California, San Francisco, CA, USA; School of Medicine, Trinity College Dublin, University of Dublin, Dublin, Ireland.

Objectives: Acquired brain injury (ABI) has long-lasting effects, and patients and their families require continued care and support, often for the rest of their lives. For many individuals living with an ABI disorder, nonpharmacological rehabilitation treatment care has become increasingly important care component and relevant for informed healthcare decision making. Our study aimed to appraise economic evidence on the cost-effectiveness of nonpharmacological interventions for individuals living with an ABI. Read More

Eur J Neurol 2022 May 7. Epub 2022 May 7.

"Rita Levi Montalcini" Department of Neuroscience, University of Turin, ALS Centre, Turin, Italy.

Background: Social Cognition (SC) deficits are included in Amyotrophic Lateral Sclerosis-Frontotemporal spectrum disorder (ALS-FTDS) revised diagnostic criteria. However, SC performances among ALS patients are heterogeneous due to the phenotypic variability of the disease and the wide range of neuropsychological tools employed. The aim of the present study was to assess Facial Emotion Recognition (FER) and Theory of Mind (ToM) in ALS patients compared to controls and to evaluate the correlations with the other cognitive domains and degree of motor impairment. Read More

J Neurosurg 2022 May 6:1-12. Epub 2022 May 6.

1Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, Utrecht.

Objective: Patients with moyamoya vasculopathy often experience cognitive impairments. In this prospective single-center study, the authors investigated the profile of neurocognitive impairment and its relation with the severity of ischemic brain lesions and hemodynamic compromise.

Methods: Patients treated in a Dutch tertiary referral center were prospectively included. Read More

Occup Ther Int 2022 19;2022:4108434. Epub 2022 Apr 19.

Department of Tax & Management, Gwangju University, Republic of Korea.

Objectives: The purpose of this study was to compare the validity and reliability of the two Korean versions of the MoCA for individuals aged ≥65 years.

Methods: A total of 185 participants aged ≥65 years were included in this cross-sectional study. This study investigated the reliability of the two Korean versions of the MoCA (the MoCA-K and MoCA-K2) by having each participant complete both assessments twice and comparing them to their Korean version of the Mini-Mental State Exam (MMSE-K) scores. Read More

Clin Interv Aging 2022 29;17:653-664. Epub 2022 Apr 29.

Department of Neurology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.

Objective: Type 2 diabetes mellitus (T2DM) and ischemic stroke, which are common diseases among older people, are closely related to cognitive impairment. This study aims to investigate the influencing factors of post-stroke cognitive impairment (PSCI) in patients with T2DM.

Methods: We enrolled 161 patients with T2DM who experienced acute ischemic stroke and were hospitalized in the Department of Neurology, Jinan Central Hospital, Shandong, China. Read More

NPJ Digit Med 2022 May 5;5(1):57. Epub 2022 May 5.

CHOC Children's, Orange, CA, USA.

Autism spectrum disorder (ASD) can be reliably diagnosed at 18 months, yet significant diagnostic delays persist in the United States. This double-blinded, multi-site, prospective, active comparator cohort study tested the accuracy of an artificial intelligence-based Software as a Medical Device designed to aid primary care healthcare providers (HCPs) in diagnosing ASD. The Device combines behavioral features from three distinct inputs (a caregiver questionnaire, analysis of two short home videos, and an HCP questionnaire) in a gradient boosted decision tree machine learning algorithm to produce either an ASD positive, ASD negative, or indeterminate output. Read More

Neurol Sci 2022 May 5. Epub 2022 May 5.

Neuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy.

Background And Aims: To explore the cognitive functioning of ET patients without dementia and delineate its imaging counterpart.

Methods: We enrolled 99 subjects (49 non-demented ET patients and 50 education-matched healthy controls) that underwent neuropsychological and MRI evaluation. In order to identify the cognitive parameters that better reflect the profile of ET patients, we used a double statistical approach: (i) direct comparison between groups and (ii) machine learning approach with feature selection. Read More

BMC Geriatr 2022 May 2;22(1):382. Epub 2022 May 2.

BerbeeWalsh Department of Emergency Medicine, University of Wisconsin-Madison, 800 University Bay Drive Suite 310, Madison, WI, 53705, USA.

Introduction: As the population ages, Alzheimer's disease and related dementias (ADRD) are becoming increasingly common in patients presenting to the emergency department (ED). This study compares the frequency of ED use among a cohort of individuals with well-defined cognitive performance (cognitively intact, mild cognitive impairment (MCI), and ADRD).

Methods: We performed a retrospective cohort study of English-speaking, community-dwelling individuals evaluated at four health system-based multidisciplinary memory clinics from 2014-2016. Read More

Front Psychiatry 2022 12;13:823605. Epub 2022 Apr 12.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Different clinical subtypes of mild cognitive impairment (MCI) involve heterogeneous underlying etiologies. This study investigated the association between demographics, neuropsychological performance, apolipoprotein E (APOE) genotype and magnetic resonance imaging (MRI) measures in patients with MCI (amnestic [aMCI] and non-amnestic [naMCI]).

Methods: This case-control study included 130 aMCI patients, 58 naMCI patients, and 1,106 healthy controls (HCs). Read More

Case Rep Neurol Med 2022 25;2022:9613600. Epub 2022 Apr 25.

Department of Neurology, Duke University Medical Center, Durham, NC, USA.

As of March 2022, over 78 million cases of COVID-19 and 900,000 deaths have been reported in the United States. The consequences in the acute phase due to the SARS-COV-2 infection are well defined. Beyond the direct effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) involving the lung parenchyma, the post-viral complications within the central nervous system are still largely unknown, and a comprehensive evaluation regarding the long-term neuropsychological sequelae from this disease is not well characterized. Read More