12,620 results match your criteria Neuropsychological Evaluation


The fate of patients with REM sleep behavior disorder and mild cognitive impairment.

Sleep Med 2020 Feb 29. Epub 2020 Feb 29.

Clinical Neurology, Dept. of Neuroscience (DINOGMI), University of Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Objective: To investigate clinical and dopaminergic pre-synaptic brain imaging characteristics of subjects with idiopathic rapid eye movement (REM) behavior disorder (iRBD) and mild cognitive impairment (MCI), and to evaluate the combined predictive value of risk factors for short-term conversion to synucleinopathy.

Method: In sum, 44 polysomnography (PSG)-confirmed iRBD patients (68.5 ± 7. Read More

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http://dx.doi.org/10.1016/j.sleep.2020.02.011DOI Listing
February 2020

Detecting subtle cognitive impairment in multiple sclerosis with the MoCA test.

Can J Neurol Sci 2020 May 26:1-22. Epub 2020 May 26.

Département de psychologie, Université du Québec à Montréal, Montréal, Canada.

Background: Although cognitive deficits are frequent in multiple sclerosis (MS), screening for them with tools such as the Montreal Cognitive Assessment (MoCA) test is usually not performed unless there is a subjective complaint. The Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) is among the instruments most commonly used to assess self-reported subjective complaints in MS. Nonetheless, it does not always accurately reflect cognitive status; many patients with cognitive deficits thus fail to receive appropriate referral for detailed neuropsychological evaluation. Read More

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http://dx.doi.org/10.1017/cjn.2020.97DOI Listing

Evaluation of neuropsychological development of children diagnosed with primary monosymptomatic nocturnal enuresis: A pilot study.

Turk J Urol 2020 Mar 11. Epub 2020 Mar 11.

Department of Pediatrics, Sultan Abdülhamid Han Training and Research Hospital, İstanbul, Turkey.

Objective: Studies on primary monosymptomatic nocturnal enuresis have supported neuromotor development delay. This study aims to examine the neuropsychological development of children with primary monosymptomatic nocturnal enuresis.

Material And Methods: This study included 30 children diagnosed with primary monosymptomatic nocturnal enuresis and 30 healthy children. Read More

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http://dx.doi.org/10.5152/tud.2020.19122DOI Listing

What happens when we forget our own narrative: Transgender dementia case study.

Clin Neuropsychol 2020 May 25:1-13. Epub 2020 May 25.

Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.

: Neuropsychological evaluations in a geriatric population have an assortment of challenges due to increased risk in the population for chronic/acute medical conditions, varied psychiatric disorders, and chronic negative lifestyle behaviors, all which impact one's cognitive functioning. One relatively new challenge is conducting cognitive evaluations within an elderly transgender population. There is a considerable lack of specific normative data in neuropsychological evaluations for transgender individuals due to the prevalence of binary gender categorization in current scoring protocols. Read More

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http://dx.doi.org/10.1080/13854046.2020.1766575DOI Listing

Evaluation of wait times for assessment and epilepsy surgery according the geographic area of residence in the province of Saskatchewan, Canada.

Seizure 2020 May 12;79:80-85. Epub 2020 May 12.

Saskatchewan Epilepsy Program, Department of Medicine, Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada. Electronic address:

Purpose: The aim of this study was to determine and compare the waiting times for surgical assessment, neuropsychological testing and epilepsy surgery between people with epilepsy who live in cities with available neurologists vs not.

Methods: We reviewed all cases referred for epilepsy surgery between 2007 and 2017 at the Saskatchewan Epilepsy Program Royal University Hospital (SEP) (n = 98; Saskatchewan, Canada). Mann-Whitney U test was used to compare wait times from first diagnosis of epilepsy to epilepsy surgery between patients who live in cities with neurologists (mainly urban areas) vs cities without neurologists (mainly rural areas). Read More

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http://dx.doi.org/10.1016/j.seizure.2020.04.014DOI Listing

[Neuropsychological profile in patients with myotonic dystrophy type 1: a four-year follow-up study].

Rev Neurol 2020 Jun;70(11):406-412

Hospital de Zumárraga, Zumárraga, España.

Introduction: Myotonic dystrophy type 1 (MD1), or Steinert's disease, is a multisystemic disorder of autosomal dominant inheritance, whose adult variant usually presents with multidomain cognitive impairment and affects patients' functionality and quality of life.

Aim: To study the four-year history of cognitive functioning in a sample of patients with the adult variant of MD1.

Patients And Methods: The neurocognitive functions of a sample of 31 patients with MD1 are evaluated, of whom 24 repeat the test administered four years ago in the Neurology Service of the Complejo Hospitalario of Navarra. Read More

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http://dx.doi.org/10.33588/rn.7011.2019455DOI Listing

[Current status of initial diagnosis of speech sound disorder in a child healthcare clinic].

Zhongguo Dang Dai Er Ke Za Zhi 2020 May;22(5):499-504

Department of Child Health Care, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing 400014, China.

Objective: To investigate the understanding of speech sound disorder (SSD) among child health practitioners.

Methods: The clinical data of 506 children with an initial diagnosis of SSD from January 2017 to May 2019 were retrospectively analyzed.

Results: Of the 506 SSD children, 90. Read More

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Comparison of Auricular Therapy with Sham in Children with Attention Deficit/Hyperactivity Disorder: A Randomized Controlled Trial.

J Altern Complement Med 2020 May 20. Epub 2020 May 20.

Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.

Several studies have shown the clinical effects of auricular therapy for some neuropsychological disorders. The aim of this study is to compare the effectiveness of auricular therapy with the sham procedure in attention deficit hyperactivity disorder (ADHD). Randomized sham-controlled trial. Read More

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http://dx.doi.org/10.1089/acm.2019.0477DOI Listing

Sporadic and Familial Variants in NF1: An Explanation of the Wide Variability in Neurocognitive Phenotype?

Front Neurol 2020 5;11:368. Epub 2020 May 5.

ToNIC, Toulouse NeuroImaging Center, University of Toulouse, Inserm, UPS, Toulouse, France.

Cognitive impairment is the most common neurological manifestation in NF1 and occurs in 30-70% of NF1 cases. The onset and severity of each specific cognitive deficit varies greatly from child to child, with no apparent external causes. The wide variability of phenotype is the most complex aspect in terms of management and care. Read More

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http://dx.doi.org/10.3389/fneur.2020.00368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214842PMC

Associations between NIH Toolbox Cognition Battery and brain amyloid and tau pathology in non-demented older adults.

Alzheimers Dement (Amst) 2020 15;12(1):e12018. Epub 2020 May 15.

Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania.

Introduction: The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB-CB) was developed to be a common assessment metric across a broad array of research studies. We investigated associations between NIHTB-CB and brain amyloid and tau deposition in cognitively unimpaired older adults.

Methods: One hundred eighteen community-based volunteers completed magnetic resonance imaging (MRI), Pittsburgh compound B (PiB)-PET (positron emission tomography) and AV-1451-PET neuroimaging, a neuropsychological evaluation, NIHTB-CB, and the Clinical Dementia Rating (CDR) scale. Read More

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http://dx.doi.org/10.1002/dad2.12018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228102PMC

Exploring driving characteristics of fit- and unfit-to-drive neurological patients: a driving simulator study.

Traffic Inj Prev 2020 May 18:1-6. Epub 2020 May 18.

Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia.

To identify driving characteristics of fit-, unfit-, and conditionally fit-to-drive neurological patient populations using a driving simulator with three high-risk scenarios comprising rural, highway, and urban environments. The study included 91 neurological patients undergoing a multidisciplinary assessment for driver's license revalidation, consisting of a clinical, neuropsychological, functional, and on-road evaluation. The groups drove through three independent driving scenarios, during which a variety of measures describing reaction time, vehicular control, and traffic rule compliance were performed. Read More

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http://dx.doi.org/10.1080/15389588.2020.1764547DOI Listing

Neuropsychological features in patients with severe mental disorders and risk of violence: A prospective multicenter study in Italy.

Psychiatry Res 2020 May 7;289:113027. Epub 2020 May 7.

Epidemiological and Evaluation Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, 25125 Brescia, Italy. Electronic address:

In Severe Mental Disorders (SMDs) the most important cognitive deficits involve the Executive Functions (EFs). In this study we examined the association between EFs and aggressive behaviour in outpatients with SMDs. We included a total of 247 outpatients divided into two groups: 'cases', patients with a history of violence (N=126) and 'non-violent' (N=121). Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113027DOI Listing

CSF p-tau/Aβ ratio and brain FDG-PET may reliably detect MCI "imminent" converters to AD.

Eur J Nucl Med Mol Imaging 2020 May 15. Epub 2020 May 15.

Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Purpose: To know whether mild cognitive impairment (MCI) patients will develop Alzheimer's disease (AD) dementia in very short time or remain stable is of crucial importance, also considering new experimental drugs usually tested within very short time frames. Here we combined cerebrospinal fluid (CSF) AD biomarkers and a neurodegeneration marker such as brain FDG-PET to define an objective algorithm, suitable not only to reliably detect MCI converters to AD dementia but also to predict timing of conversion.

Methods: We included 77 consecutive MCI patients with neurological/neuropsychological assessment, brain 18F-FDG-PET and CSF analysis available at diagnosis and a neuropsychological/neurological evaluation every 6 months for a medium- to a long-term follow-up (at least 2 and up to 8 years). Read More

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http://dx.doi.org/10.1007/s00259-020-04853-4DOI Listing

A Neuropsychological Investigation of Perfectionism.

Behav Ther 2020 May 12;51(3):488-502. Epub 2019 Sep 12.

Texas State University. Electronic address:

Perfectionism entails a burdensome preoccupation with one's self-evaluation in the context of performance outcomes. Although perfectionism has been subject to extensive research, scant literature on its effect on cognitive functioning is available, let alone in nonclinical populations. The aim of the present study is to utilize a comprehensive neuropsychological battery to assess cognitive functions among college students with high and low levels of perfectionism. Read More

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http://dx.doi.org/10.1016/j.beth.2019.09.002DOI Listing

Social Cognition in Rehabilitation Context: Different Evolution of Affective and Cognitive Theory of Mind in Mild Cognitive Impairment.

Behav Neurol 2020 4;2020:5204927. Epub 2020 Jan 4.

Department of Human and Social Science, Università degli Studi di Bergamo, Bergamo, Italy.

Maintaining social skills such as Theory of Mind (ToM) competences is important to counteract the conversion into dementia in Mild Cognitive Impairment (MCI). Multidimensional nonpharmacological interventions demonstrated their potential in improving cognitive and behavioral abilities; however, little is known about the long-term effect of such interventions on social skills in people with MCI. The aim of this longitudinal study was to monitor ToM competences considering both cognitive and affective domains in an amnestic MCI (aMCI) sample involved in a home-based multistimulation treatment (MST@H). Read More

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http://dx.doi.org/10.1155/2020/5204927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199603PMC
January 2020

Cross-validation of non-memory-based embedded performance validity tests for detecting invalid performance among patients with and without neurocognitive impairment.

J Clin Exp Neuropsychol 2020 May 13:1-14. Epub 2020 May 13.

Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA.

: Embedded performance validity tests (PVTs) allow for continuous and economical validity assessment during neuropsychological evaluations; however, similar to their freestanding counterparts, a limitation of well-validated embedded PVTs is that the majority are memory-based. This study cross-validated several previously identified non-memory-based PVTs derived from language, processing speed, and executive functioning tests within a single mixed clinical neuropsychiatric sample with and without cognitive impairment.: This cross-sectional study included data from 124 clinical patients who underwent outpatient neuropsychological evaluation. Read More

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http://dx.doi.org/10.1080/13803395.2020.1758634DOI Listing

Understanding the neuropsychological effects of 3q29 deletion Syndrome: A fraternal twin case study.

Appl Neuropsychol Child 2020 May 12:1-7. Epub 2020 May 12.

The Neuropsychology Center of Louisiana at Gretna, Gretna, LA, USA.

In 2005, the 3q29 Deletion Syndrome was identified and defined as a rare chromosomal anomaly that effects approximately one in 30,000-40,000 children. It has a complex neuropsychiatric profile but often results in developmental delay, intellectual disability, attentional deficits, classic physical traits, behavioral health disturbances, as well as social and emotional issues. Rarely has this syndrome been seen and evaluated in fraternal twins, only one of whom has the 3q29 Deletion Syndrome. Read More

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http://dx.doi.org/10.1080/21622965.2020.1757445DOI Listing

Epilepsy surgery beyond 50 years: Long-term seizure and cognitive outcomes.

J Neurol Sci 2020 May 1;414:116872. Epub 2020 May 1.

Epilepsy Unit, Department of Neurology, Hospital Universitario y Politécnico La Fe, Avinguda de Fernando Abril Martorell, 106, 46026 Valencia, Spain.

Introduction: Surgery is a well-demonstrated effective treatment for patients with refractory epilepsy. However, there are scarce data about the efficacy in older patients. Endpoint was to evaluate the outcome of epilepsy surgery in pharmacorresistant patients operated in middle-late adulthood. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116872DOI Listing

Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning.

Brain Behav Immun 2020 May 6. Epub 2020 May 6.

Memory and Aging Center, Department of Neurology, University of California, San Francisco, United States; Weill Institute for Neurosciences, United States.

Objective: Exercise is one of the most potent strategies available to support cognitive health with age, yet substantial variability exists. Sexual dimorphism is evident for brain and immune functioning, the latter being implicated as important pathway for exercise. We examined the moderating role of sex on the relationship between physical activity and systemic inflammatory and brain health outcomes in support of more personalized approaches to behavioral interventions. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.05.014DOI Listing

[Cognitive impairment after intensive care unit discharge: a Meta-analysis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Mar;32(3):350-356

Center of Evidence-Based Medicine, Lanzhou University, Lanzhou 730000, Gansu, China. Corresponding author: Zhang Zhigang, Email:

Objective: To investigate the cognitive impairment after intensive care unit (ICU) discharge and provide theoretical basis for prevention and intervention.

Methods: Studies about cognitive impairment after ICU discharge were retrieved in PubMed, Embase, Cochrane Library, Web of Science, Wanfang data, CNKI and SinoMed from their foundation to December 2019. The literature screening and data extraction were performed by two researchers independently, and the quality of different types of researches was evaluated using Cochrane Handbook 5. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20200213-00180DOI Listing

The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG).

J Clin Med 2020 May 6;9(5). Epub 2020 May 6.

IRCCS Fondazione Don Carlo Gnocchi ONLUS, via Capecelatro 66, 20148 Milan, Italy.

Due to the lack of pharmacological treatment for dementia, timely detection of subjects at risk can be of seminal importance for preemptive rehabilitation interventions. The aim of the study was to determine the usability of the smart aging serious game (SASG), a virtual reality platform, in assessing the cognitive profile of an amnestic mild cognitive impairment (aMCI) population, its validity in discriminating aMCI from healthy controls (HC), and in detecting hippocampal degeneration, a biomarker of clinical progression towards dementia. Thirty-six aMCI and 107 HC subjects were recruited and administered the SASG together with a neuropsychological evaluation. Read More

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http://dx.doi.org/10.3390/jcm9051355DOI Listing

Assessing the predictive value of primary evaluation with the Immediate Post-Concussion Assessment and Cognitive Test following head injury.

J Neurosurg Pediatr 2020 May 8:1-8. Epub 2020 May 8.

1Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York.

Objective: Concussions are a major public health concern, especially for high school and college student athletes. However, there are few prognostic metrics that can accurately quantify concussion severity in order to anticipate recovery time and symptom regression. The Immediate Post-Concussion Assessment and Cognitive Test (ImPACT) is a widely used neurocognitive assessment that can diagnose and track recovery from concussions. Read More

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http://dx.doi.org/10.3171/2020.2.PEDS19709DOI Listing

A new clinical evaluation of asomatognosia in right brain damaged patients using visual and reaching tasks.

J Clin Exp Neuropsychol 2020 May 7:1-14. Epub 2020 May 7.

Department of Psychology, University of Milano Bicocca, Milan, Italy.

: The term asomatognosia refers to a unilateral disturbance of body ownership following a cerebrovascular incident. Patients with asomatognosia consider the contralesional limbs as missing or having disappeared from awareness. This neuropsychological disorder modifies body ownership in terms of perceptual experience, visual identification and sense of belonging of contralesional body parts. Read More

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http://dx.doi.org/10.1080/13803395.2020.1757040DOI Listing

The Behavior Rating Inventory of Executive Function®-Adult Version is Related to Emotional Distress, Not Executive Dysfunction, in a Veteran Sample.

Arch Clin Neuropsychol 2020 May 7. Epub 2020 May 7.

Department of Veterans Affairs Medical Center, Memphis, TN, USA.

Objective: In three studies, we explore the impact of response bias, symptom validity, and psychological factors on the self-report form of the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) and the relationship between self-reported executive functioning (EF) and objective performance.

Method: Each study pulled from a sample of 123 veterans who were administered a BRIEF-A and Minnesota Multiphasic Personality Inventory-2 (MMPI-2) during a neuropsychological evaluation. Participants were primarily middle-aged, and half carried a mood disorder diagnosis. Read More

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http://dx.doi.org/10.1093/arclin/acaa024DOI Listing

The Impact of Self-Efficacy and Health Locus of Control on Performance Validity Testing.

Arch Clin Neuropsychol 2020 May 7. Epub 2020 May 7.

Desmond Doss Health Clinic, Schofield Barracks, HI, USA.

Objective: Recent research has examined potential influences to performance validity testing beyond intentional feigning. The current study sought to examine the hypothesized relationships of two psychological constructs (self-efficacy and health locus of control) with performance validity testing (PVT).

Method: Retrospective review of 158 mild traumatic brain injury (mTBI) cases referred to an Army outpatient clinic for neuropsychological evaluation. Read More

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http://dx.doi.org/10.1093/arclin/acaa027DOI Listing

Web-Based Intervention Effects on Mild Cognitive Impairment Based on Apolipoprotein E Genotype: Quasi-Experimental Study.

J Med Internet Res 2020 May 7;22(5):e14617. Epub 2020 May 7.

Medical Physics Laboratory, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer disease and mild cognitive impairment (MCI). Computer-based training programs can improve cognitive performance in elderly populations. However, the effects of computer-based interventions on MCI APOE ε4 carriers have never been studied before. Read More

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http://dx.doi.org/10.2196/14617DOI Listing

Retrospective Analysis of the Test of Memory Malingering in a Low Intellectual Quotient Intractable Epilepsy Sample.

Arch Clin Neuropsychol 2020 May 6. Epub 2020 May 6.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Objective: The Test of Memory Malingering (TOMM) is commonly used by neuropsychologists (Sharland, M. J., & Gfeller, J. Read More

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http://dx.doi.org/10.1093/arclin/acaa022DOI Listing

Multidimensional Malingering Criteria for Neuropsychological Assessment: A 20-Year Update of the Malingered Neuropsychological Dysfunction Criteria.

Arch Clin Neuropsychol 2020 May 6. Epub 2020 May 6.

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.

Objectives: Empirically informed neuropsychological opinion is critical for determining whether cognitive deficits and symptoms are legitimate, particularly in settings where there are significant external incentives for successful malingering. The Slick, Sherman, and Iversion (1999) criteria for malingered neurocognitive dysfunction (MND) for malingered neurocognitive dysfunction (MND) are considered a major milestone in the field's operationalization of neurocognitive malingering and have strongly influenced the development of malingering detection methods, including serving as the criterion of malingering in the validation of several performance validity tests (PVTs) and symptom validity tests (SVTs) (Slick, D.J. Read More

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http://dx.doi.org/10.1093/arclin/acaa019DOI Listing

Community-Based Eye Health Screening Study in the Elderly Hispanic Population in North Texas.

Tex Public Health J 2020 ;72(2):19-21

North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX.

The Hispanic population is underserved and underrepresented in health care. Epidemiological studies are cmcial for providing insight to identify disparities and unmet eye health needs in this vulnerable group. The purpose of our study is to examine the prevalence of ocular conditions in the elderly Hispanic population in North Texas and identify the frequency in which these conditions were undiagnosed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202570PMC
January 2020

Development and Evaluation of Maze-Like Puzzle Games to Assess Cognitive and Motor Function in Aging and Neurodegenerative Diseases.

Front Aging Neurosci 2020 21;12:87. Epub 2020 Apr 21.

Gerontechnology & Rehabilitation, University of Bern, Bern, Switzerland.

There is currently a need for engaging, user-friendly, and repeatable tasks for assessment of cognitive and motor function in aging and neurodegenerative diseases. This study evaluated the feasibility of a maze-like Numberlink puzzle game in assessing differences in game-based measures of cognition and motor function due to age and neurodegenerative diseases. Fifty-five participants, including young (18-31 years, = 18), older (64-79 years, = 14), and oldest adults (86-98 years, = 14), and patients with Parkinson's (59-76 years, = 4) and Huntington's disease (HD; 35-66 years, = 5) played different difficulty levels of the Numberlink puzzle game and completed usability questionnaires and tests for psychomotor, attentional, visuospatial, and constructional and executive function. Read More

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http://dx.doi.org/10.3389/fnagi.2020.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188385PMC

Cognitive phenotypes in temporal lobe epilepsy utilizing data- and clinically driven approaches: Moving toward a new taxonomy.

Epilepsia 2020 May 4. Epub 2020 May 4.

San Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.

Objective: To identify cognitive phenotypes in temporal lobe epilepsy (TLE) and test their reproducibility in a large, multi-site cohort of patients using both data-driven and clinically driven approaches.

Method: Four-hundred seven patients with TLE who underwent a comprehensive neuropsychological evaluation at one of four epilepsy centers were included. Scores on tests of verbal memory, naming, fluency, executive function, and psychomotor speed were converted into z-scores based on 151 healthy controls (HCs). Read More

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http://dx.doi.org/10.1111/epi.16528DOI Listing

Evaluation of the risk factors for neurological and neurocognitive impairment after selective cerebral perfusion in thoracic aortic surgery.

J Anesth 2020 May 2. Epub 2020 May 2.

Department of Anesthesiology, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.

Purpose: Neurologic complications are seen often after the surgery of the thoracic aorta that uses selective antegrade cerebral perfusion. The objective of this study was to evaluate the impact of atherosclerotic risk factors on neurologic complications in patients who underwent surgery to the thoracic aorta using SCP.

Methods: Data were collected retrospectively on 94 patients who underwent elective ascending aorta/aortic arch replacement. Read More

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http://dx.doi.org/10.1007/s00540-020-02783-xDOI Listing

Effects of 2-year treatment with dimethyl fumarate on cognition and functional impairment in patients with relapsing remitting multiple sclerosis.

Neurol Sci 2020 May 1. Epub 2020 May 1.

Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy.

Background: A significant proportion of patients with multiple sclerosis (MS) show cognitive impairment.

Objective: To evaluate the effect of 2-year treatment with oral dimethyl fumarate (DMF) on cognition in relapsing remitting MS (RRMS).

Methods: In this prospective single-arm study RRMS patients treated with DMF underwent a wide battery of tests, including an extensive neuropsychological evaluation, clinical and patient-reported outcomes (PROs) and quality of life (QoL). Read More

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http://dx.doi.org/10.1007/s10072-020-04320-wDOI Listing

Test of variables of attention performance among ADHD children with credible vs. non-credible PVT performance.

Appl Neuropsychol Child 2020 May 1:1-7. Epub 2020 May 1.

The Nicholls Group, Scottdale, AZ, USA.

The assessment of effort is a crucial step in the evaluation of children and adolescents who present with symptoms of an Attention-Deficit/Hyperactivity Disorder (ADHD). Studies with adults have found that a large percentage of individuals claiming to have ADHD fail performance validity measures. In children, failure on PVT measures is associated with lower scores on a wide array of neuropsychological measures. Read More

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http://dx.doi.org/10.1080/21622965.2020.1751787DOI Listing

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer's disease.

Alzheimers Res Ther 2020 Apr 30;12(1):50. Epub 2020 Apr 30.

School of Psychology, Vita-Salute San Raffaele University, Milan, Italy.

Background: Early-onset Alzheimer's disease (EOAD) is characterized by young age of onset (< 65 years), severe neurodegeneration, and rapid disease progression, thus differing significantly from typical late-onset Alzheimer's disease. Growing evidence suggests a primary role of neuroinflammation in AD pathogenesis. However, the role of microglia activation in EOAD remains a poorly explored field. Read More

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http://dx.doi.org/10.1186/s13195-020-00619-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193377PMC

Late-Onset Epilepsy With Unknown Etiology: A Pilot Study on Neuropsychological Profile, Cerebrospinal Fluid Biomarkers, and Quantitative EEG Characteristics.

Front Neurol 2020 15;11:199. Epub 2020 Apr 15.

Neurology Clinic, University of Perugia-S. Maria della Misericordia Hospital, Perugia, Italy.

Despite the fact that epilepsy has been associated with cognitive decline, neuropsychological, neurobiological, and neurophysiological features in patients with late-onset epilepsy of unknown etiology (LOEU) are still unknown. This cross-sectional study aims to investigate the neuropsychological profile, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD), and resting-state quantitative electroencephalographic (qEEG) cortical rhythms in LOEU patients with mild cognitive impairment (LOEU-MCI) and with normal cognition (LOEU-CN), compared to non-epileptic MCI (NE-MCI) and cognitively normal (CN) controls. Consecutive patients in two clinical Units diagnosed with LOEU-CN (19), LOEU-MCI (27), and NE-MCI (21) were enrolled, and compared to age and sex-matched cognitively normal subjects CN (11). Read More

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http://dx.doi.org/10.3389/fneur.2020.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174783PMC

Performance Validity Testing in Multiple Sclerosis.

J Int Neuropsychol Soc 2020 Apr 28:1-8. Epub 2020 Apr 28.

Department of Neurology, Cleveland Clinic, Cleveland, OH, USA.

Objective: Performance validity tests (PVTs) are designed to detect nonvalid responding on neuropsychological testing, but their associations with disease-specific and other factors are not well understood in multiple sclerosis (MS). We examined PVT performance among MS patients and associations with clinical characteristics, cognition, mood, and disability status.

Method: Retrospective data analysis was conducted on a sample of patients with definite MS (n = 102) who were seen for a clinical neuropsychological evaluation. Read More

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http://dx.doi.org/10.1017/S1355617720000466DOI Listing

Assessment of Cortical Auditory Function Using Electrophysiological and Neuropsychological Measurements in Children with Bone-Anchored Hearing Aids.

J Med Life 2020 Jan-Mar;13(1):102-106

Department of Neurosciences, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Children suffering from conductive or mixed hearing loss may benefit from a bone-anchored hearing aid system (BAHA Attract implantable prosthesis). After audiological rehabilitation, different aspects of development are improving. The objective of this case report is to propose a comprehensive framework for monitoring cortical auditory function after implantation of a bone-anchored hearing aid system by using electrophysiological and neuropsychological measurements. Read More

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http://dx.doi.org/10.25122/jml-2019-0097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175444PMC

High-frequency cardiopulmonary coupling during sleep correlates with memory in depressed patients: A pilot study.

J Affect Disord 2020 Jun 8;270:118-123. Epub 2020 Apr 8.

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

Background: It has been demonstrated that a reduction in the amount of high-frequency cardiopulmonary coupling (CPC) is indicative of unstable sleep in unmedicated patients with major depressive disorder (MDD). Considering the close relationship between sleep quality and memory consolidation, this study sought to investigate the potential of high-frequency CPC as a novel biomarker for objective evaluation of memory impairment in MDD.

Methods: A total of 64 depressed patients and 35 healthy controls were included in this cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.jad.2020.03.058DOI Listing

Two distinct phenotypes, hemiplegic migraine and episodic Ataxia type 2, caused by a novel common CACNA1A variant.

BMC Neurol 2020 Apr 26;20(1):155. Epub 2020 Apr 26.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialities, Specialities "G. D'Alessandro," University of Palermo, Palermo, Italy.

Background: To investigate the genetic and environmental factors responsible for phenotype variability in a family carrying a novel CACNA1A missense mutation. Mutations in the CACNA1A gene were identified as responsible for at least three autosomal dominant disorders: FHM1 (Familial Hemiplegic Migraine), EA2 (Episodic Ataxia type 2), and SCA6 (Spinocerebellar Ataxia type 6). Overlapping clinical features within individuals of some families sharing the same CACNA1A mutation are not infrequent. Read More

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http://dx.doi.org/10.1186/s12883-020-01704-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183684PMC

Early putamen hypertrophy and ongoing hippocampus atrophy predict cognitive performance in the first ten years of relapsing-remitting multiple sclerosis.

Neurol Sci 2020 Apr 24. Epub 2020 Apr 24.

Multiple Sclerosis Center, Neurology Unit, Department of Medical Sciences, University Hospital and Health Services of Trieste, University of Trieste, Strada di Fiume, 447, 34149, Trieste, Italy.

Background: The first years of relapsing-remitting multiple sclerosis (RRMS) constitute the most vulnerable phase for the progression of cognitive impairment (CImp), due to a gradual decrease of compensatory mechanisms. In the first 10 years of RRMS, the temporal volumetric changes of deep gray matter structures must be clarified, since they could constitute reliable cognitive biomarkers for diagnostic, prognostic, and therapeutic purposes.

Methods: Forty-five cognitively asymptomatic patients with RRMS lasting ≤ 10 years, and with a brain MRI performed in a year from the neuropsychological evaluation (Te-MRI), were included. Read More

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http://dx.doi.org/10.1007/s10072-020-04395-5DOI Listing

132 Treating Comorbid Childhood Bipolar Disorder and ADHD.

CNS Spectr 2020 Apr;25(2):283-284

Clinical Assistant; The Neuropsychology Center of Louisiana; Baton Rouge, LA.

Objectives: According to Nemeth et al. (2011), pediatric mania is difficult to distinguish from childhood hyperactivity. Both share 3 common symptoms: distractibility, motoric hyperactivity, and talkativeness (Biederman, 2000). Read More

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http://dx.doi.org/10.1017/S1092852920000486DOI Listing

[Neuropsychological assessment protocol for adults in epilepsy surgery].

Rev Neurol 2020 May;70(9):341-347

Fundación San Andrés, Mendoza., Argentina.

Introduction: Refractory epilepsy means that the seizures are untreatable, and therefore one of the interventions that makes it possible to eliminate them or to accomplish a reduction in the number of seizures is neurosurgery.

Development: A neuropsychological evaluation model aimed at measuring the cognitive performance of adult patients who are candidates for epilepsy surgery is proposed. In line with the proposals most frequently put forward by the various reference centres for epilepsy, an open protocol is proposed that is aimed at obtaining a baseline of overall cognitive performance, cognitive reserve and manual dominance, as well as cognitive processes such as attention, language, visuoconstructive and manipulative skills, memory and executive functions, among others, without neglecting the psychopathological examination and the patient's quality of life. Read More

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http://dx.doi.org/10.33588/rn.7009.2019441DOI Listing

Report of a Case of Creutzfeldt-Jakob Disease With an Unusual Clinical Presentation.

Front Behav Neurosci 2020 9;14:55. Epub 2020 Apr 9.

Department of Neurology, Neuropsychology and Behavioral Neurology Research Unit, Neurocenter of Southern Switzerland, Lugano, Switzerland.

We describe the clinical features, neuropsychological tests, laboratory, electroencephalography (EEG), magnetic resonance imaging (MRI) and positron emission tomography (PET) findings of a 59-year-old woman who presented to our Centre for cognitive impairment since few months, with language disturbances, particularly anomia, dyscalculia, and memory loss. The clinical and neuropsychological features were non-specific and overlapping with those of other rapidly progressing neurodegenerative disorders. However, brain MRI played a pivotal role in the diagnosis, showing cortical diffusion restriction, particularly in the parietal lobes and posterior cingulum, with sparing of the perirolandic cortex, typical of Creutzfeldt-Jakob disease (CJD). Read More

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http://dx.doi.org/10.3389/fnbeh.2020.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161217PMC

The use of functional magnetic resonance imaging techniques in the evaluation of patients with disorders of consciousness: a case report.

Pol J Radiol 2020 4;85:e118-e124. Epub 2020 Mar 4.

Department of Radiological and Isotopic Diagnosis and Therapy, Medical University of Lodz, Poland.

Purpose: The management of patients with disorders of consciousness (DOC) constitutes a challenge for clinicians.

Case Report: We present the case of a 66-year-old man who developed coma with subsequent DOC after a severe traumatic brain injury. Behavioural assessment constitutes the gold standard in the evaluation of patients with DOC. Read More

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http://dx.doi.org/10.5114/pjr.2020.93664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172223PMC

South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial.

J Clin Neurol 2020 Apr;16(2):292-303

Department of Neurology, Inha University School of Medicine, Incheon, Korea.

Background And Purpose: The prevalence of dementia is increasing in South Korea. Multidomain interventions may be useful for preventing dementia. Such programs need to be disseminated to elderly Koreans throughout the country. Read More

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http://dx.doi.org/10.3988/jcn.2020.16.2.292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174118PMC

Base Rates of Invalid Test Performance Across Clinical Non-forensic Contexts and Settings.

Arch Clin Neuropsychol 2020 Apr 21. Epub 2020 Apr 21.

Department of Psychiatry and Behavioral Sciences, University of Kansas School of Medicine, Wichita, KS, USA.

Objective: Base rates of invalidity in forensic neuropsychological contexts are well explored and believed to approximate 40%, whereas base rates of invalidity across clinical non-forensic contexts are relatively less known.

Methods: Adult-focused neuropsychologists (n = 178) were surveyed regarding base rates of invalidity across various clinical non-forensic contexts and practice settings. Median values were calculated and compared across contexts and settings. Read More

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http://dx.doi.org/10.1093/arclin/acaa017DOI Listing

Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis.

Neurology 2020 May 21;94(18):e1876-e1884. Epub 2020 Apr 21.

From the Department of Clinical Neurosciences (A.L.); Department of Neurology (A.L., L.G., R.Y., P.K.P.); Department of Neuroimaging and Interventional Radiology (J.S.); Department of Psychiatry (S.S.A.); Department of Clinical Psychology (S.H.), National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India; Symbiosis Center for Medical Image Analysis (M.I., A.S.), Symbiosis Institute of Technology (M.I.), Symbiosis International (Deemed University), Lavale, India; and Department of Neurology (A.L.), MedStar Georgetown University Hospital, Washington, DC.

Objective: The objective of the current study was to compare the microstructural integrity of the white matter (WM) tracts in patients having Parkinson disease (PD) with and without psychosis (PD-P and PD-NP) through diffusion tensor imaging (DTI).

Methods: This cross-sectional study involved 48 PD-NP and 42 PD-P who were matched for age, sex, and education. Tract-based spatial statistics (TBSS) was used to compare several DTI metrics from the diffusion-weighted MRIs obtained through a 3-Tesla scanner. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009363DOI Listing

Neuropsychological management of the awake patient surgery: A protocol based on 3-year experience with glial tumors.

Neurocirugia (Astur) 2020 Apr 18. Epub 2020 Apr 18.

Servicio de Neurocirugía, Hospital 12 de Octubre, Madrid, España; Instituto de Investigación Biomédica i+12, Madrid, España; Departamento de Cirugía, Facultad de Medicina UCM, Madrid, España.

Introduction: Glial brain tumours usually require neurosurgical treatment and they are associated with cognitive, emotional and behavioural impairments. Awake intraoperative brain mapping is the gold standard technique used to optimize the onco-functional balance. Neuropsychological assessment and intervention have relevance in this type of procedures. Read More

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http://dx.doi.org/10.1016/j.neucir.2020.02.005DOI Listing

The correlation of neuropsychological evaluation with 11C-PiB and 18F-FC119S amyloid PET in mild cognitive impairment and Alzheimer disease.

Medicine (Baltimore) 2020 Apr;99(16):e19620

Department of Neurology.

For the diagnosis of mild cognitive impairment (MCI) and Alzheimer disease (AD), variable neuroimaging and neuropsychological tests have been used. We aimed to evaluate the correlation of neuropsychological domain with new amyloid positron emission tomography (PET) study and to validate the availability of new PET tracer.We enrolled 20 patients who underwent C-PiB-PET/CT, new PET tracer F-FC119S PET/CT from November, 2014 to July, 2015. Read More

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http://dx.doi.org/10.1097/MD.0000000000019620DOI Listing