2,622 results match your criteria Neuropsychiatric Disease and Treatment[Journal]


Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy.

Neuropsychiatr Dis Treat 2019 28;15:753-761. Epub 2019 Mar 28.

Department of Psychology, Chung Shan Medical University, Taichung, Taiwan,

Purpose: This cross-sectional pilot study aimed to compare the effects of chemotherapy and targeted therapy on neuropsychological performance and psychiatric symptoms in patients with non-small-cell lung cancer (NSCLC).

Patients And Methods: A total of 113 patients with NSCLC were recruited. According to their type of cancer treatment, the patients were classified into chemotherapy (n=40), targeted therapy (n=33), and untreated control (n=40) groups. Read More

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http://dx.doi.org/10.2147/NDT.S194642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446983PMC

Relationships between Internet addiction and clinicodemographic and behavioral factors.

Neuropsychiatr Dis Treat 2019 26;15:739-752. Epub 2019 Mar 26.

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan,

Backgrounds And Aims: While the Internet became an indispensable component of our contemporary life, public and academic attention is also gathered to its negative impact, namely Internet addiction (IA). Although clinicodemographic and behavioral factors are hypothetically implicated in the mechanism of IA, it still remains largely unknown how such factors are linked to IA severity. Thus, this study sought to examine relationships among IA severity and factors potentially associated with IA in Japanese students in different educational stages. Read More

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http://dx.doi.org/10.2147/NDT.S193357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440534PMC

Predictors of achieving remission in schizophrenia patients treated with paliperidone palmitate 3-month formulation.

Neuropsychiatr Dis Treat 2019 22;15:731-737. Epub 2019 Mar 22.

Janssen Scientific Affairs, LLC, Titusville, NJ 08560, USA,

Purpose: Long-acting injectable (LAI) antipsychotic paliperidone palmitate 3-month formulation (PP3M) is indicated in the United States for the treatment of schizophrenia only after adequate treatment with paliperidone palmitate 1-month formulation (PP1M) for ≥4 months. This analysis aimed to identify patient and disease characteristics during PP1M treatment associated with greater likelihood of achieving remission after transition to PP3M.

Methods: A post hoc analysis of a randomized, Phase III, double-blind, noninferiority trial of PP3M vs PP1M (ClinicalTrials. Read More

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http://dx.doi.org/10.2147/NDT.S194264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435125PMC
March 2019
1 Read

Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies.

Neuropsychiatr Dis Treat 2019 21;15:721-729. Epub 2019 Mar 21.

Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, People's Republic of China.

Objective: The zinc finger protein 804A () gene encodes the protein 804A containing the C2H2 zinc finger structure, which plays an important role in embryonic nerve development and repair. Previous studies have shown a significant association between the genetic variation polymorphism rs1344706 and the risk of schizophrenia and brain structure abnormalities. However, the findings are inconsistent. Read More

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http://dx.doi.org/10.2147/NDT.S174728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432899PMC
March 2019
1 Read

Impaired comprehension of metaphorical expressions in very mild Alzheimer's disease.

Neuropsychiatr Dis Treat 2019 20;15:713-720. Epub 2019 Mar 20.

Department of Neurology, Kurashiki Heisei Hospital, Kurashiki, Okayama, Japan.

Background: Brain-damaged patients often have difficulty understanding non-literal language. However, whether patients with Alzheimer's disease (AD) have comprehension deficits of metaphorical expressions, in contrast with non-metaphorical (literal) expressions, remains unclear.

Patients And Methods: The subjects were 40 AD patients; 20 had mild AD (17-23 points on the Mini-Mental State Examination [MMSE]), and 20 had very mild AD (≥24 points). Read More

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http://dx.doi.org/10.2147/NDT.S193645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430997PMC
March 2019
1 Read

Repetitive transcranial magnetic stimulation in trauma-related conditions.

Neuropsychiatr Dis Treat 2019 19;15:701-712. Epub 2019 Mar 19.

Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea,

Some of trauma-exposed individuals develop posttraumatic stress disorder (PTSD), an incapacitating psychiatric disorder that is characterized by intrusion, avoidance, negative changes in mood and cognition, and hyperarousal. A number of other trauma-related conditions are very frequently found in individuals with PTSD. Traumatic brain injury (TBI) is one of the most frequently observed trauma-related conditions that trauma-exposed individuals with PTSD may experience. Read More

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http://dx.doi.org/10.2147/NDT.S189498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430993PMC
March 2019
1 Read
2.154 Impact Factor

Identification of key genes, pathways, and miRNA/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis.

Neuropsychiatr Dis Treat 2019 14;15:685-700. Epub 2019 Mar 14.

Shandong Co-Innovation Center of Classic TCM formula, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, People's Republic of China,

Introduction: Major depressive disorder (MDD) is a recurrent, devastating mental disorder, which affects >350 million people worldwide, and exerts substantial public health and financial costs to society. Thus, there is a significant need to discover innovative therapeutics to treat depression efficiently. Stress-induced dysfunction in the subtype of neuronal cells and the change of synaptic plasticity and structural plasticity of nucleus accumbens (NAc) are implicated in depression symptomology. Read More

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http://dx.doi.org/10.2147/NDT.S200264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421879PMC
March 2019
1 Read
2.154 Impact Factor

The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis.

Neuropsychiatr Dis Treat 2019 12;15:675-684. Epub 2019 Mar 12.

Department of Endocrinology, Tianjin First Center Hospital, Tianjin, China,

Objective: Recent controversial evidence suggests that maternal diabetes may increase the risk of attention deficit and hyperactivity disorder (ADHD) in offspring. To examine this potential association, a systematic literature search and meta-analysis was performed.

Methods: OR or risk ratio (RR) from each study was obtained and combined for evaluating the risk. Read More

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http://dx.doi.org/10.2147/NDT.S189200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419587PMC
March 2019
1 Read

Effects of prenatal exposure to temephos on behavior and social interaction.

Neuropsychiatr Dis Treat 2019 11;15:669-673. Epub 2019 Mar 11.

Neurobiology Laboratory of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil,

The neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (OP). The OP is neurotoxic and has been associated with neurological diseases pathophysiology. The OP temephos is widely used against in Brazil's public health programs. Read More

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http://dx.doi.org/10.2147/NDT.S193896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417020PMC
March 2019
1 Read

Effects of melatonin in children with attention-deficit/hyperactivity disorder with sleep disorders after methylphenidate treatment.

Neuropsychiatr Dis Treat 2019 7;15:663-667. Epub 2019 Mar 7.

Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK.

Purpose: Methylphenidate (MPH), the first-line medication in children with attention-deficit/hyperactivity disorder (ADHD), is associated with increased risk of sleep disorders. Melatonin has both hypnotic and chronobiotic properties that influence circadian rhythm sleep disorders. This study explores the effectiveness of melatonin in children with ADHD who developed sleep problems after starting MPH. Read More

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http://dx.doi.org/10.2147/NDT.S193891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410756PMC
March 2019
6 Reads

and genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity.

Neuropsychiatr Dis Treat 2019 7;15:657-661. Epub 2019 Mar 7.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, P.R. China,

Purpose: Venlafaxine is one of the commonly prescribed antidepressants for major depressive disorder (MDD). Accumulated evidence revealed the involvement of glutamatergic system in the pathophysiology of MDD and antidepressant treatment.

Methods: We recruited 193 MDD patients who have been taking venlafaxine for 6 weeks, and investigated whether single nucleotide polymorphisms (SNPs) in and were associated with treatment response. Read More

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http://dx.doi.org/10.2147/NDT.S191376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410750PMC
March 2019
1 Read

Erratum: Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations [Corrigendum].

Authors:

Neuropsychiatr Dis Treat 2019 5;15:655. Epub 2019 Mar 5.

[This corrects the article on p. 1535 in vol. 14, PMID: 29950838. Read More

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http://dx.doi.org/10.2147/NDT.S205205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407900PMC
March 2019
1 Read

Odor perception and hedonics in chronic schizophrenia and in first episode psychosis.

Neuropsychiatr Dis Treat 2019 5;15:647-654. Epub 2019 Mar 5.

Department of Affective and Psychotic Disorders, Medical University of Łódź, Łódź, Poland,

Background And Purpose: The study evaluated olfactory performance and pleasantness rating of odors in patients with first episode psychosis (FEP) and chronic schizophrenia (SCH) with regard to the severity of psychopathological symptoms and plasma β-endorphin concentration.

Patients And Methods: Twenty patients with FEP, 27 with SCH and 29 healthy individuals, were recruited to the research . The University of Pennsylvania Smell Identification Test (UPSIT), subjective odor hedonic judgment and plasma levels of β-endorphin (BE) assay were performed in all participants. Read More

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http://dx.doi.org/10.2147/NDT.S192523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407904PMC
March 2019
1 Read

Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints.

Neuropsychiatr Dis Treat 2019 4;15:637-645. Epub 2019 Mar 4.

Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea,

Purpose: We aimed to investigate the relationships of cerebral amyloid beta (Aβ) deposition and neurodegeneration (ND) with subjective memory complaints (SMCs) in cognitively normal (CN) individuals, focusing specially on the modulating effects of vascular risk (VR) on those relationships.

Participants And Methods: A total of 230 CN elderly individuals underwent comprehensive clinical assessments including the Subjective Memory Complaints Questionnaire (SMCQ), VR assessment, and multimodal brain imaging including [C] Pittsburgh compound B positron emission tomography (PET), [F] fluorodeoxyglucose-PET, and magnetic resonance imaging.

Results: We found a significant overall positive association between cerebral Aβ retention and SMCQ score. Read More

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http://dx.doi.org/10.2147/NDT.S192231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404991PMC

Prevalence and outcomes of Guillain-Barré syndrome among pediatrics in Saudi Arabia: a 10-year retrospective study.

Neuropsychiatr Dis Treat 2019 1;15:627-635. Epub 2019 Mar 1.

Science and Technology Unit, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia,

Background: Guillain-Barré syndrome (GBS) is a progressive acute form of paralysis most probably secondary to an immune-mediated process. GBS among Saudis has been seldom investigated, which leaves both clinicians and researchers with scarcity in knowledge. Therefore, this study aims to assess the prevalence and clinical prognosis of GBS among pediatrics admitted with acute paralysis at a large healthcare facility in Riyadh, Saudi Arabia. Read More

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http://dx.doi.org/10.2147/NDT.S187994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400135PMC
March 2019
1 Read

Social cognitive training for adults with Noonan syndrome: a feasibility study.

Neuropsychiatr Dis Treat 2019 26;15:611-626. Epub 2019 Feb 26.

Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands,

Purpose: Noonan syndrome (NS) is a genetic disorder that is associated with social cognitive problems. While treatment aimed at the improvement of social cognition is available for other neuropsychiatric disorders, no such interventions yet exist for NS patients. In this study, the development of the first social cognitive training for NS patients is described and its applicability and feasibility evaluated. Read More

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http://dx.doi.org/10.2147/NDT.S179527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396661PMC
February 2019
1 Read

Racial and ethnic differences in depression: current perspectives.

Neuropsychiatr Dis Treat 2019 22;15:603-609. Epub 2019 Feb 22.

Department of Psychiatry, Wake Forest School of Medicine, Winston-Salem, NC, USA,

Major depressive disorder (MDD) is among the most prevalent disorders in the US that often goes underdiagnosed and untreated. The burden of disability among those untreated is heaviest among untreated minority populations. Recent studies show that among African Americans, those with socioeconomic stress are less likely to report psychological symptoms or remain compliant with initiated treatment. Read More

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http://dx.doi.org/10.2147/NDT.S128584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390869PMC
February 2019
6 Reads

Efficacy and safety of paliperidone palmitate 3-month versus 1-month formulation in patients with schizophrenia: comparison between European and non-European population.

Neuropsychiatr Dis Treat 2019 21;15:587-602. Epub 2019 Feb 21.

Medical & Scientific Affairs, Janssen Cilag EMEA, Neuss, Germany.

Purpose: This randomized, double-blind (DB), non-inferiority phase 3 study was conducted to assess the efficacy and safety of paliperidone palmitate 3-month (PP3M) vs 1-month formulation (PP1M) in European and non-European patients with schizophrenia.

Patients And Methods: In this randomized, DB, parallel-group study, adult patients (18-70 years) with schizophrenia (per DSM-IV-TR) having Positive and Negative Syndrome Scale (PANSS) total score between 70 and 120; previously stabilized on PP1M were enrolled. The study had 4 phases: screening (3 weeks), open-label (OL) stabilization (17 weeks), DB (48 weeks) and follow-up (4-12 weeks) phase. Read More

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http://dx.doi.org/10.2147/NDT.S189668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391122PMC
February 2019
3 Reads

Evaluation of plasma levels of neopterin and soluble CD40 ligand in patients with acute ischemic stroke in upper Egypt: can they surrogate the severity and functional outcome?

Neuropsychiatr Dis Treat 2019 22;15:575-586. Epub 2019 Feb 22.

Department of Clinical Pathology, Faculty of Medicine, Aswan University, Aswan, Egypt.

Background: Inflammation constitutes a major component of ischemic stroke pathology. The prognostic value of "neopterin" and soluble CD40 ligand (sCD40L), as a potential biomarker of ischemic stroke, has been less extensively studied.

Objectives Of The Study: This study aims at assessing the serum levels of neopterin and sCD40L in acute ischemic stroke (AIS), to clarify its association with the severity, etiology, and risk factors of stroke, and to evaluate their relationship with the stroke functional outcome in our study sample within 90 days of follow-up. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390873PMC
http://dx.doi.org/10.2147/NDT.S177726DOI Listing
February 2019

Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach.

Neuropsychiatr Dis Treat 2019 20;15:557-573. Epub 2019 Feb 20.

The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia,

Much of human interaction is predicated upon our innate capacity to infer the thoughts, beliefs, emotions, and perspectives of others, in short, to possess a "theory of mind" (ToM). While the term has evolved considerably since its inception, ToM encompasses our unique ability to apprehend the mental states of others, enabling us to anticipate and predict subsequent behavior. From a developmental perspective, ToM has been a topic of keen research interest, with numerous studies seeking to explicate the origins of this fundamental capacity and its disruption in developmental disorders such as autism. Read More

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http://dx.doi.org/10.2147/NDT.S158996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388953PMC
February 2019

Clinical feature and outcome of late-onset cobalamin C disease patients with neuropsychiatric presentations: a Chinese case series.

Neuropsychiatr Dis Treat 2019 21;15:549-555. Epub 2019 Feb 21.

Department of Neurology, Qilu Hospital, Shandong University, Jinan, China,

Objective: The Cobalamin C (cblC) disease is an inborn error of cobalamin metabolism. Late-onset cblC disease was diagnosed in patients having overt symptoms after 4 years of age. The late-onset cblC disease patients were rare and easily misdiagnosed. Read More

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http://dx.doi.org/10.2147/NDT.S196924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391119PMC
February 2019

Aripiprazole for the treatment of psychotic symptoms in patients with dementia with Lewy bodies: a case series.

Neuropsychiatr Dis Treat 2019 22;15:543-547. Epub 2019 Feb 22.

Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita 010-8543, Japan,

Purpose: The core features of dementia with Lewy bodies (DLB) are cognitive fluctuations, visual hallucinations, and parkinsonian symptoms. Although there have been several reports on the efficacy of treatments for psychotic symptoms in patients with DLB, little is known regarding the treatment effects of aripiprazole. The aim of this study was to evaluate the efficacy and safety of aripiprazole for the treatment of psychotic symptoms in patients with DLB. Read More

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http://dx.doi.org/10.2147/NDT.S189050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390858PMC
February 2019
2 Reads

Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats.

Neuropsychiatr Dis Treat 2019 20;15:531-542. Epub 2019 Feb 20.

Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates,

Background: Alzheimer disease (AD) is the main cause of dementia in elderly people. The potential of histamine H3 receptor (H3R) antagonists as a pharmacological treatment of several neuropsychiatric diseases is well established.

Methods: The novel non-imidazole-based H3R antagonist E177 was screened for its pro-cognitive effects on the inhibitory avoidance paradigm (IAP) and novel object recognition (NOR) task in a dizocilpine (DIZ)-induced model of amnesia in male Wistar rats. Read More

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http://dx.doi.org/10.2147/NDT.S193125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388968PMC
February 2019
3 Reads

The interactive effects of stress and coping style on cognitive function in patients with schizophrenia.

Neuropsychiatr Dis Treat 2019 21;15:523-530. Epub 2019 Feb 21.

Division of Nursing Fundamentals, School of Nursing, Shandong University, Jinan, Shandong, China,

Purpose: Previous studies have not determined the interactive effects of stress and coping style on cognitive function in patients with schizophrenia, and the current studies have been restricted to the relationship between stress and stress response, which may be associated with cognitive impairment in individuals with schizophrenia. The present research was aimed to determine whether stress is related to cognitive function in patients with schizophrenia. In addition, this research further investigates the moderating effects of coping style on the relationship between stress and cognitive function in patients with schizophrenia on the basis of stress and coping theory. Read More

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http://dx.doi.org/10.2147/NDT.S181471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391124PMC
February 2019
2 Reads

Diabetes and elevated preoperative HbA1c level as risk factors for postoperative delirium after cardiac surgery: an observational cohort study.

Neuropsychiatr Dis Treat 2019 20;15:511-521. Epub 2019 Feb 20.

Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Szczecin, Poland,

Introduction: Postoperative delirium (POD) is a common complication of cardiac surgery associated with increased mortality, morbidity, and long-term cognitive dysfunction. Diabetic patients, especially those with poor diabetes control and long-standing hyperglycemia, may be at risk of developing delirium. The aim of this study was to analyze whether the occurrence of POD in cardiac surgery is associated with diabetes or elevated preoperative glycated hemoglobin (HbA1c) level. Read More

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http://dx.doi.org/10.2147/NDT.S196973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388975PMC
February 2019
3 Reads

Bipolar spectrum disorders and associated factors among adults attending an antiretroviral therapy clinic in Gedeo zone health centers, southern Ethiopia.

Neuropsychiatr Dis Treat 2019 20;15:503-509. Epub 2019 Feb 20.

Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Bipolar spectrum disorders (BPSDs) are more common among HIV-positive individuals than the general population. Although BPSDs have very diverse and devastating consequences (immune suppression, cognitive impairment and poor medication adherence), little is known about BPSDs among HIV-positive individuals in Ethiopia. Therefore, this study was aimed to assess the prevalence and associated factors of BPSDs among adults attending antiretroviral therapy (ART) clinics in Gedeo zone health centers, southern Ethiopia. Read More

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http://dx.doi.org/10.2147/NDT.S187669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388964PMC
February 2019
2 Reads

Aberrant attentive and inattentive brain activity to auditory negative words, and its relation to persecutory delusion in patients with schizophrenia.

Neuropsychiatr Dis Treat 2019 14;15:491-502. Epub 2019 Feb 14.

Department of Psychiatry, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu City, Japan,

Background And Purpose: Previous research has suggested that deficits in emotion recognition are involved in the pathogenesis of persecutory delusion in schizophrenia. Although disruption in auditory and language processing is crucial in the pathophysiology of schizophrenia, the neural basis for the deficits in emotion recognition of auditorily presented language stimuli and its relation to persecutory delusion have not yet been clarified.

Patients And Methods: The current functional magnetic resonance imaging study used a dichotic listening task for 15 patients with schizophrenia and 23 healthy controls matched for age, sex, parental socioeconomic background, handedness, dexterous ear, and intelligence quotient. Read More

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http://dx.doi.org/10.2147/NDT.S194353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387602PMC
February 2019
2.154 Impact Factor

Stimuli may have little impact on the deficit of visual working memory accuracy in first-episode schizophrenia.

Neuropsychiatr Dis Treat 2019 18;15:481-489. Epub 2019 Feb 18.

Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China,

Purpose: Working memory (WM) deficits have been observed in people with schizophrenia (SZ) and are considered a core cognitive dysfunction in these patients. However, little is known about how stimuli and memory load influence visual WM deficits.

Patients And Methods: In the present study, we adopted a match-to-sample task to examine the visual WM in 18 first-episode patients with SZ and 18 healthy controls (HCs). Read More

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http://dx.doi.org/10.2147/NDT.S188645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387591PMC
February 2019
1 Read
2.154 Impact Factor

Radio electric asymmetric conveyer neuromodulation in depression, anxiety, and stress.

Neuropsychiatr Dis Treat 2019 13;15:469-480. Epub 2019 Feb 13.

Department of Neuro Psycho Physio Pathology and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy,

Background: The purpose of this study was to assess the efficacy of specific neuromodulation treatments performed with radio electric asymmetric conveyer (REAC) technology in the treatment of the symptomatic triad depression, anxiety, and stress by the use of a specific psychometric test such as the Depression Anxiety Stress Scale-42 items (DASS-42) version, which assesses simultaneously the severity of expression of this triad.

Patients And Methods: The design of this study was planned to compare two populations that performed DASS-42 test twice within a similar period of time. The first population performed the first DASS test before the treatment and the second test about 3 months later, at the end of two specific REAC neuromodulation treatments, neuropostural optimization (NPO) and neuropsychophysical optimization (NPPO), that have previously shown an efficacy in the treatment of depression, anxiety and stress. Read More

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http://dx.doi.org/10.2147/NDT.S195466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387613PMC
February 2019
1 Read

Durability of symptomatic responses obtained with adjunctive vagus nerve stimulation in treatment-resistant depression.

Neuropsychiatr Dis Treat 2019 13;15:457-468. Epub 2019 Feb 13.

Department of Psychiatry and Behavioral Sciences, National University of Singapore, Singapore.

Objective: To compare the durations of response achieved with adjunctive vagus nerve stimulation (VNS + TAU) vs treatment as usual (TAU) alone in treatment-resistant depression (TRD) over a 5-year period in the TRD registry.

Materials And Methods: Data from 271 participants on TAU and 328 participants on VNS + TAU were analyzed. Response was defined as ≥50% decrease in baseline Montgomery-Åsberg Depression Rating Scale (MADRS) score at postbaseline visit and was considered retained until the decrease was <40%. Read More

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http://dx.doi.org/10.2147/NDT.S196665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387594PMC
February 2019
1 Read
2.154 Impact Factor

Addenbrooke's cognitive examination III in the diagnosis of dementia: a critical review.

Neuropsychiatr Dis Treat 2019 15;15:441-447. Epub 2019 Feb 15.

Neuropsicología y Rehabilitación Cognitiva, Instituto de Neurociencias Cognitivas y Traslacional (INCyT), Fundación INECO, Universidad Favaloro, CONICET, Buenos Aires, Argentina,

Addenbrooke's cognitive examination III is a screening test that is composed of tests of attention, orientation, memory, language, visual perceptual and visuospatial skills. It is useful in the detection of cognitive impairment, especially in the detection of Alzheimer's disease and fronto-temporal dementia. The aim of this study is to do a critical review of the Addenbrooke's cognitive examination III. Read More

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http://dx.doi.org/10.2147/NDT.S151253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387595PMC
February 2019
13 Reads

Role of paliperidone palmitate 3-monthly in the management of schizophrenia: insights from clinical practice.

Neuropsychiatr Dis Treat 2019 11;15:449-456. Epub 2019 Feb 11.

Department of Pharmacy Practice, Nova Southeastern University, Fort Lauderdale, FL, USA,

Schizophrenia is a complex, chronic psychiatric disorder associated with reduced quality of life and shortened life span. The majority of patients with schizophrenia will relapse within 1 year following an acute episode. The ultimate goals of treatment are to improve functional capabilities, minimize residual symptoms during periods of remission, and decrease relapse frequency and duration, as each relapse brings with it the possibility of a worsening prognosis. Read More

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http://dx.doi.org/10.2147/NDT.S140383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375110PMC
February 2019
1 Read

The effect of night shift on sleep quality and depressive symptoms among Chinese nurses.

Neuropsychiatr Dis Treat 2019 7;15:435-440. Epub 2019 Feb 7.

Anji County People's Hospital, Huzhou 313300, China,

Purpose: Night shift is associated with adverse physical and psychological health outcomes such as poor sleep quality and depressive symptoms. We aimed to compare sleep quality as well as depressive symptoms in nurses working night shifts to those working day shifts only and explore the association between sleep quality and depressive symptoms among nurses.

Patients And Methods: Eight hundred sixty-five nurses were enrolled in the current study. Read More

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http://dx.doi.org/10.2147/NDT.S190689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369837PMC
February 2019
1 Read

Stimulus intensity determined by dose-titration versus age-based methods in electroconvulsive therapy in Thai patients.

Neuropsychiatr Dis Treat 2019 7;15:429-434. Epub 2019 Feb 7.

Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Objectives: This study aimed to compare the accuracy of the stimulus intensity (SI) calculated by age-based methods with that using the dose-titration method.

Methods: The initial seizure threshold (IST) was determined using a standardized dose titration in hospitalized Thai patients treated with right unilateral (RUL, n=32) and bilateral (BL, n=57) electrode placement. The correlation between the IST and clinical variables was analyzed. Read More

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http://dx.doi.org/10.2147/NDT.S187589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369840PMC
February 2019
3 Reads

Analysis of motor performance in individuals with cerebral palsy using a non-immersive virtual reality task - a pilot study.

Neuropsychiatr Dis Treat 2019 4;15:417-428. Epub 2019 Feb 4.

Postgraduate Program in Rehabilitation Sciences, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil,

Purpose: To evaluate the performance improvement of individuals with hemiparesis cerebral palsy (CP) using a virtual task.

Participants And Methods: Twenty individuals were selected and distributed into two groups. The experimental group (CP group) comprised ten individuals with a medical diagnosis of CP, and ten individuals with typical development (sex- and age-matched) composed the control group (TD group). Read More

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http://dx.doi.org/10.2147/NDT.S184510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366350PMC
February 2019
2 Reads

HDAC4 gene silencing alleviates epilepsy by inhibition of GABA in a rat model.

Neuropsychiatr Dis Treat 2019 4;15:405-416. Epub 2019 Feb 4.

Department of Neurosurgery and Laboratory of Neurosurgery, Lanzhou University Second Hospital, Lanzhou 730030, People's Republic of China,

Objectives: Despite the availability of effective antiepileptic drugs, epileptic patients still suffer from intractable seizures and adverse events. Better control of both seizures and fewer side effects is needed in order to enhance the patient's quality of life. We performed the present study with an attempt to explore the effect that HDAC4 gene silencing would have on epilepsy simulated by model rats. Read More

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http://dx.doi.org/10.2147/NDT.S181669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366349PMC
February 2019
2 Reads

Mild cognitive decline in type 2 diabetes mellitus patients - risk factors and pathogenesis: role of DPP4 activity and future possible therapeutic targets.

Authors:
Owais Gul Saqib Gul

Neuropsychiatr Dis Treat 2019 4;15:403-404. Epub 2019 Feb 4.

Department of Medicine, Hamdard University, Karachi, Pakistan.

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http://dx.doi.org/10.2147/NDT.S200663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366363PMC
February 2019
2 Reads

Clinical factors influencing resilience in patients with anorexia nervosa.

Neuropsychiatr Dis Treat 2019 30;15:391-395. Epub 2019 Jan 30.

Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima-shi, Tokushima, Japan.

Purpose: This study was to elucidate clinical factors influencing resilience in anorexia nervosa (AN) patients.

Patients And Methods: Twenty female patients with AN (median age =30.0 years, quartile deviation =6. Read More

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http://dx.doi.org/10.2147/NDT.S190725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365225PMC
January 2019
4 Reads

Evacuation of chronic and subacute subdural hematoma via transcranial neuroendoscopic approach.

Neuropsychiatr Dis Treat 2019 30;15:385-390. Epub 2019 Jan 30.

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province 430060, China Email

Objective: To evaluate the effectiveness and safety of neuroendoscopic surgery for chronic or subacute subdural hematoma.

Patients And Methods: Between September 2016 and September 2018, neuroendoscopic surgery was performed on 25 patients with chronic and subacute subdural hematoma. Hematoma evacuation was performed with a 0°, 4 mm diameter rigid neuroendoscope via a transcranial neuroendoscopic approach. Read More

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http://dx.doi.org/10.2147/NDT.S193548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365224PMC
January 2019
1 Read

Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms.

Neuropsychiatr Dis Treat 2019 29;15:375-383. Epub 2019 Jan 29.

Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan,

Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Read More

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https://www.dovepress.com/genetic-effects-on-white-matter-in
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http://dx.doi.org/10.2147/NDT.S190268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357876PMC
January 2019
3 Reads

Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway.

Neuropsychiatr Dis Treat 2019 25;15:369-374. Epub 2019 Jan 25.

Department of Emergency, Zhuji People's Hospital of Zhejiang Province, Zhuji, Zhejiang, China,

Background: Given that the therapeutic effect of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) has been debated for a long time, it is necessary to clarify the mechanism underlying the effect of HBO on acute TBI.

Methods: This study investigated the effect of HBO therapy on neuronal apoptosis induced by acute TBI using the mouse model of TBI. The number of apoptotic cells and expression of apoptosis-associated factors (including caspase 3, pAkt/Akt, pGSK3β/GSK3β, and β-catenin) in pericontusional cortices of mice exposed to sham, TBI, and TBI + HBO treatment were measured and analyzed using TUNEL assay, quantitative reverse-transcription PCR, and Western blot. Read More

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http://dx.doi.org/10.2147/NDT.S183632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354685PMC
January 2019
1 Read

Lack of association between genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses.

Neuropsychiatr Dis Treat 2019 25;15:357-367. Epub 2019 Jan 25.

Department of Cardiology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China,

Background: In recent years, there has been substantial research evaluating the relationship between arachidonate 5-lipoxygenase-activating protein () polymorphisms and ischemic stroke (IS). The objective of this study was to systematically review and analyze the existing evidence.

Methods: A comprehensive search of major electronic databases for studies published between 1990 and 2018 was carried out. Read More

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http://dx.doi.org/10.2147/NDT.S182674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354695PMC
January 2019
1 Read

A novel approach to cardiovascular disturbances in patients with schizophrenia spectrum disorders treated with long-acting injectable medication.

Neuropsychiatr Dis Treat 2019 25;15:349-355. Epub 2019 Jan 25.

Medical Semiology II, Department of Internal Medicine I, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.

Purpose: This research article assesses the cardiovascular impact of long-term injectable antipsychotic therapy on patients diagnosed with schizophrenia spectrum disorders. In our study, we attempted to quantify the potential causes of cardiovascular damage, assess cardiovascular parameters, and correlate them with the time elapsed from the onset of the psychosis until the initiation of injectable antipsychotic therapy, as well as the duration of long-acting therapy, and finally, to compare two of the most utilized long-acting injectable (LAI) medications (olanzapine vs risperidone).

Patients And Methods: This cross-sectional study recruited 64 patients of 2 outpatient clinics undergoing treatment with LAI antipsychotics for schizophrenic spectrum disorder. Read More

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http://dx.doi.org/10.2147/NDT.S186892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354682PMC
January 2019
3 Reads

The association between gene rs13212041 polymorphism and onset of alcohol abuse.

Neuropsychiatr Dis Treat 2019 24;15:339-347. Epub 2019 Jan 24.

Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia,

Background: Alcohol dependence displays a wide variety of clinical phenotypes. Various typology classifications of alcoholism include age of onset of alcohol abuse as one of the major phenotypic features. Serotonergic changes have been associated with alcoholism, while serotonin receptors type 1B (5-HT1B) play an important role in regulating serotonergic neurotransmission. Read More

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http://dx.doi.org/10.2147/NDT.S191457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353223PMC
January 2019
4 Reads

Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy.

Neuropsychiatr Dis Treat 2019 23;15:323-337. Epub 2019 Jan 23.

Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province 710038, China,

Background: Both protective and therapeutic functions of insulin-like growth factor-1 (IGF-1) in brain injury have been reported, but its effects on cognitive sequelae after septic encephalopathy (SE) remain unclear.

Materials And Methods: This study was divided into three parts, and a septic model was built by cecal ligation and puncture (CLP). First, survival analysis was performed, and IGF-1's effects on long-term cognition and depressive emotion were assessed. Read More

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http://dx.doi.org/10.2147/NDT.S190845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353230PMC
January 2019
2 Reads
2.154 Impact Factor

Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation.

Neuropsychiatr Dis Treat 2019 23;15:311-321. Epub 2019 Jan 23.

CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada,

Background: Cigarette smoking is the leading preventable cause of death; however, quitting is difficult and early relapse is common. Dysphoric mood during early cigarette withdrawal is associated with relapse, and with the exception of bupropion and nortriptyline, few interventions have been developed to prevent this. During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood. Read More

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http://dx.doi.org/10.2147/NDT.S172334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352866PMC
January 2019

Cytokines and chemokines expression in serum of patients with neuromyelitis optica.

Neuropsychiatr Dis Treat 2019 21;15:303-310. Epub 2019 Jan 21.

Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, People's Republic of China,

Objective: To study the differences in immunopathogenesis based on chemokine profile in neuromyelitis optica patients positive for AQP4 antibodies or MOG antibodies.

Patients And Methods: We measured 52 cytokines/chemokines using ELISA in 59 serum samples, which were divided into three groups according to CBA results: HCs (n=16), AQP4+ (n=20) and MOG+ (n=23). The regression equation (>0. Read More

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http://dx.doi.org/10.2147/NDT.S185336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345185PMC
January 2019

Negative and positive self-thoughts predict subjective quality of life in people with schizophrenia.

Neuropsychiatr Dis Treat 2019 21;15:293-301. Epub 2019 Jan 21.

Department of Psychiatry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Purpose: Recently, cognitive variables such as negative and positive self-belief and thoughts have attracted much attention because they are associated with functional outcomes and quality of life (QOL). However, it is unclear how cognitive variables affect subjective and objective QOL. This study aimed to investigate the relationship of negative and positive self-belief and thoughts with subjective and objective QOL. Read More

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http://dx.doi.org/10.2147/NDT.S190381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345191PMC
January 2019
4 Reads

Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study.

Neuropsychiatr Dis Treat 2019 18;15:283-291. Epub 2019 Jan 18.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, China,

Background: The results of previous studies have indicated that pain-associated diseases can result in marked functional and anatomical alterations in the brain. However, differences in spontaneous brain activity occurring in toothache (TA) patients remain unclear.

Objective: This study investigated intrinsic brain activity changes in TA subjects using the amplitude of low-frequency fluctuation (ALFF) technique. Read More

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https://www.dovepress.com/altered-intrinsic-brain-activity-i
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http://dx.doi.org/10.2147/NDT.S189962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342150PMC
January 2019
5 Reads