2,583 results match your criteria Neuropsychiatric Disease and Treatment[Journal]


Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms.

Neuropsychiatr Dis Treat 2019 29;15:375-383. Epub 2019 Jan 29.

Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan,

Background: A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility polymorphisms may affect white matter (WM) integrity. This study aimed to investigate the relationship between WM alterations and 17 SNPs in candidate genes for MDD in the first depressive episode of drug-naive MDD patients using a tract-based spatial statistics (TBSS) method. Read More

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http://dx.doi.org/10.2147/NDT.S190268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357876PMC
January 2019
1 Read

Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway.

Neuropsychiatr Dis Treat 2019 25;15:369-374. Epub 2019 Jan 25.

Department of Emergency, Zhuji People's Hospital of Zhejiang Province, Zhuji, Zhejiang, China,

Background: Given that the therapeutic effect of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) has been debated for a long time, it is necessary to clarify the mechanism underlying the effect of HBO on acute TBI.

Methods: This study investigated the effect of HBO therapy on neuronal apoptosis induced by acute TBI using the mouse model of TBI. The number of apoptotic cells and expression of apoptosis-associated factors (including caspase 3, pAkt/Akt, pGSK3β/GSK3β, and β-catenin) in pericontusional cortices of mice exposed to sham, TBI, and TBI + HBO treatment were measured and analyzed using TUNEL assay, quantitative reverse-transcription PCR, and Western blot. Read More

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http://dx.doi.org/10.2147/NDT.S183632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354685PMC
January 2019

Lack of association between genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses.

Neuropsychiatr Dis Treat 2019 25;15:357-367. Epub 2019 Jan 25.

Department of Cardiology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China,

Background: In recent years, there has been substantial research evaluating the relationship between arachidonate 5-lipoxygenase-activating protein () polymorphisms and ischemic stroke (IS). The objective of this study was to systematically review and analyze the existing evidence.

Methods: A comprehensive search of major electronic databases for studies published between 1990 and 2018 was carried out. Read More

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http://dx.doi.org/10.2147/NDT.S182674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354695PMC
January 2019

A novel approach to cardiovascular disturbances in patients with schizophrenia spectrum disorders treated with long-acting injectable medication.

Neuropsychiatr Dis Treat 2019 25;15:349-355. Epub 2019 Jan 25.

Medical Semiology II, Department of Internal Medicine I, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.

Purpose: This research article assesses the cardiovascular impact of long-term injectable antipsychotic therapy on patients diagnosed with schizophrenia spectrum disorders. In our study, we attempted to quantify the potential causes of cardiovascular damage, assess cardiovascular parameters, and correlate them with the time elapsed from the onset of the psychosis until the initiation of injectable antipsychotic therapy, as well as the duration of long-acting therapy, and finally, to compare two of the most utilized long-acting injectable (LAI) medications (olanzapine vs risperidone).

Patients And Methods: This cross-sectional study recruited 64 patients of 2 outpatient clinics undergoing treatment with LAI antipsychotics for schizophrenic spectrum disorder. Read More

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http://dx.doi.org/10.2147/NDT.S186892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354682PMC
January 2019

The association between gene rs13212041 polymorphism and onset of alcohol abuse.

Neuropsychiatr Dis Treat 2019 24;15:339-347. Epub 2019 Jan 24.

Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia,

Background: Alcohol dependence displays a wide variety of clinical phenotypes. Various typology classifications of alcoholism include age of onset of alcohol abuse as one of the major phenotypic features. Serotonergic changes have been associated with alcoholism, while serotonin receptors type 1B (5-HT1B) play an important role in regulating serotonergic neurotransmission. Read More

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http://dx.doi.org/10.2147/NDT.S191457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353223PMC
January 2019

Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy.

Neuropsychiatr Dis Treat 2019 23;15:323-337. Epub 2019 Jan 23.

Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province 710038, China,

Background: Both protective and therapeutic functions of insulin-like growth factor-1 (IGF-1) in brain injury have been reported, but its effects on cognitive sequelae after septic encephalopathy (SE) remain unclear.

Materials And Methods: This study was divided into three parts, and a septic model was built by cecal ligation and puncture (CLP). First, survival analysis was performed, and IGF-1's effects on long-term cognition and depressive emotion were assessed. Read More

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http://dx.doi.org/10.2147/NDT.S190845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353230PMC
January 2019
1 Read

Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation.

Neuropsychiatr Dis Treat 2019 23;15:311-321. Epub 2019 Jan 23.

CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada,

Background: Cigarette smoking is the leading preventable cause of death; however, quitting is difficult and early relapse is common. Dysphoric mood during early cigarette withdrawal is associated with relapse, and with the exception of bupropion and nortriptyline, few interventions have been developed to prevent this. During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood. Read More

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http://dx.doi.org/10.2147/NDT.S172334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352866PMC
January 2019

Cytokines and chemokines expression in serum of patients with neuromyelitis optica.

Neuropsychiatr Dis Treat 2019 21;15:303-310. Epub 2019 Jan 21.

Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, People's Republic of China,

Objective: To study the differences in immunopathogenesis based on chemokine profile in neuromyelitis optica patients positive for AQP4 antibodies or MOG antibodies.

Patients And Methods: We measured 52 cytokines/chemokines using ELISA in 59 serum samples, which were divided into three groups according to CBA results: HCs (n=16), AQP4+ (n=20) and MOG+ (n=23). The regression equation (>0. Read More

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http://dx.doi.org/10.2147/NDT.S185336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345185PMC
January 2019

Negative and positive self-thoughts predict subjective quality of life in people with schizophrenia.

Neuropsychiatr Dis Treat 2019 21;15:293-301. Epub 2019 Jan 21.

Department of Psychiatry, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Purpose: Recently, cognitive variables such as negative and positive self-belief and thoughts have attracted much attention because they are associated with functional outcomes and quality of life (QOL). However, it is unclear how cognitive variables affect subjective and objective QOL. This study aimed to investigate the relationship of negative and positive self-belief and thoughts with subjective and objective QOL. Read More

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http://dx.doi.org/10.2147/NDT.S190381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345191PMC
January 2019
2 Reads

Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study.

Neuropsychiatr Dis Treat 2019 18;15:283-291. Epub 2019 Jan 18.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, China,

Background: The results of previous studies have indicated that pain-associated diseases can result in marked functional and anatomical alterations in the brain. However, differences in spontaneous brain activity occurring in toothache (TA) patients remain unclear.

Objective: This study investigated intrinsic brain activity changes in TA subjects using the amplitude of low-frequency fluctuation (ALFF) technique. Read More

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https://www.dovepress.com/altered-intrinsic-brain-activity-i
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http://dx.doi.org/10.2147/NDT.S189962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342150PMC
January 2019
2 Reads

Frequency-dependent neural activity in primary angle-closure glaucoma.

Neuropsychiatr Dis Treat 2019 18;15:271-282. Epub 2019 Jan 18.

Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi 330006, People's Republic of China,

Objective: In this study, we aimed to investigate the frequency-dependent spontaneous neural activity in primary angle-closure glaucoma (PACG) using the amplitude of low-frequency fluctuations (ALFF) method.

Patients And Methods: In total, 52 PACG individuals (24 males and 28 females) and 52 normal-sighted controls (NS; 24 males and 28 females) who were closely matched in age, sex, and education underwent resting-state magnetic resonance imaging scans. A repeated-measures ANOVA and post hoc two-sample -tests were conducted to analyze the different ALFF values in two different frequency bands (slow-4, 0. Read More

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https://www.dovepress.com/frequency-dependent-neural-activit
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http://dx.doi.org/10.2147/NDT.S187367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342137PMC
January 2019
4 Reads

Association between anxious distress in a major depressive episode and bipolarity.

Neuropsychiatr Dis Treat 2019 15;15:267-270. Epub 2019 Jan 15.

Department of Psychiatry, Tokyo Women's Medical University Hospital, Tokyo, Japan.

Purpose: Mixed features in a major depressive episode (MDE) predict bipolar disorder (BD). The mixed features specifier included in the Fifth Edition (DSM-5) could be restrictive because it excludes the symptoms common to both mania/hypomania and depression, including psychomotor agitation. On the other hand, an anxious distress (ANXD) specifier has also been introduced in the DSM-5, and psychomotor agitation has been defined as a severity of ANXD. Read More

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http://dx.doi.org/10.2147/NDT.S188947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339637PMC
January 2019
1 Read

Serum BICC1 levels are significantly different in various mood disorders.

Neuropsychiatr Dis Treat 2019 15;15:259-265. Epub 2019 Jan 15.

Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, PR China,

Purpose: Mood disorders are recurrent chronic disorders with fluctuating mood states and energy, and misdiagnosis is common when based solely on clinical interviews because of overlapping symptoms. Because misdiagnosis may lead to inappropriate treatment and poor prognosis, finding an easily implemented objective tool for the discrimination of different mood disorders is very necessary and urgent. However, there has been no accepted objective tool until now. Read More

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http://dx.doi.org/10.2147/NDT.S190048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339641PMC
January 2019

Brexpiprazole for the maintenance treatment of adults with schizophrenia: an evidence-based review and place in therapy.

Neuropsychiatr Dis Treat 2019 15;15:247-257. Epub 2019 Jan 15.

Department of Psychiatry and Behavioral Science, New York Medical College, Valhalla, NY, USA,

The purpose of this review is to describe the available data for brexpiprazole in the maintenance treatment of schizophrenia. This objective was completed by searching the databases PubMed, Embase, and ClinicalTrials.gov to identify relevant study results presented as papers or abstracts. Read More

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https://www.dovepress.com/brexpiprazole-for-the-maintenance-
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http://dx.doi.org/10.2147/NDT.S169369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339638PMC
January 2019
5 Reads

Reliability and validity of the Depression and Somatic Symptoms Scale among patients with chronic low back pain.

Neuropsychiatr Dis Treat 2019 14;15:241-246. Epub 2019 Jan 14.

Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan,

Background: The Depression and Somatic Symptoms Scale (DSSS), which is a free scale that includes a depression subscale (DS) and a somatic subscale (SS), was developed to evaluate depression and somatic symptoms simultaneously. This study aimed to examine the reliability and validity of the DSSS among patients with chronic low back pain (CLBP).

Methods: Two-hundred and twenty-five patients with CLBP were enrolled. Read More

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http://dx.doi.org/10.2147/NDT.S188277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338111PMC
January 2019

Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder.

Neuropsychiatr Dis Treat 2019 14;15:233-240. Epub 2019 Jan 14.

Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic,

Background: Mitochondrial dysfunctions are implicated in the pathophysiology of mood disorders. We measured and examined the following selected mitochondrial parameters: citrate synthase (CS) activity, electron transport system (ETS) complex (complexes I, II, and IV) activities, and mitochondrial respiration in blood platelets.

Patients And Methods: The analyses were performed for 24 patients suffering from a depressive episode of bipolar affective disorder (BD), compared to 68 patients with MDD and 104 healthy controls. Read More

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http://dx.doi.org/10.2147/NDT.S188964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338116PMC
January 2019

Lower vitamin D levels are associated with depression in patients with gout.

Neuropsychiatr Dis Treat 2019 14;15:227-231. Epub 2019 Jan 14.

Department of Endocrinology, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China,

Background: Depression is commonly observed among patients with gout. Low levels of vitamin D have been associated with depression in non-gout subjects. We examined the association of vitamin D levels with depression in patients with gout. Read More

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http://dx.doi.org/10.2147/NDT.S193114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338117PMC
January 2019
1 Read

Health-related quality of life and its correlates in Japanese patients with myotonic dystrophy type 1.

Neuropsychiatr Dis Treat 2019 14;15:219-226. Epub 2019 Jan 14.

Department of Clinical Research Support, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan.

Purpose: Myotonic dystrophy type 1 (DM1) is a common form of muscular dystrophy that presents with a variety of symptoms that can affect patients' quality of life (QoL). Despite the importance of clarifying patients' subjective experience in both physical and psychosocial aspects for improved symptom management, there is lack of evidence concerning QoL of patients with DM1 in Japan.

Patients And Methods: A cross-sectional study was performed with 51 DM1 patients who completed questionnaires that measured health-related QoL (HRQoL), depression, and daytime sleepiness. Read More

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http://dx.doi.org/10.2147/NDT.S187607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338121PMC
January 2019

Association analysis of polymorphisms in and near in Alzheimer's disease patients carrying the ε4 Allele.

Neuropsychiatr Dis Treat 2019 11;15:213-218. Epub 2019 Jan 11.

Department of Geriatric Psychiatry, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, Wuxi, Jiangsu Province, China,

Background And Purpose: Lipid metabolism plays an important role in Alzheimer's disease (AD), and recent evidence suggests that single nucleotide polymorphisms (SNPs) in the StAR-related lipid transfer domain 6 () and near the enzyme enoyl CoA hydratase domain containing 3 () gene are related to plasma lipid levels or lipid traits in AD.

Materials And Methods: To identify whether the variants in or near the and genes contribute to AD susceptibility, we carried out an association analysis of rs10164112 and rs7920721 in combination with the apolipoprotein E () ε4 allele in a case-control study (278 cases, 509 controls) in China.

Results: We identified that SNP rs10164112 in the gene was a risk factor associated with AD and the ε4 carriers (all <0. Read More

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http://dx.doi.org/10.2147/NDT.S186705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333153PMC
January 2019
2.154 Impact Factor

Attitudes toward long-acting injectable antipsychotics among patients with schizophrenia in Japan.

Neuropsychiatr Dis Treat 2019 9;15:205-211. Epub 2019 Jan 9.

Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan,

Background: Long-acting injectable antipsychotics (LAIs) are regarded as an important alternative to oral medication for patients with schizophrenia. However, LAIs remain under-utilized in clinical practice.

Aims: The aims of this investigation were to 1) obtain information on patients' attitudes toward LAIs and 2) assess factors associated with patients' acceptance of LAIs, and 3) identify predictors of the discrepancy between patients and referring psychiatrists' opinions regarding the appropriateness for LAIs. Read More

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https://www.dovepress.com/attitudes-toward-long-acting-injec
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http://dx.doi.org/10.2147/NDT.S188337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330975PMC
January 2019
13 Reads

Prevalence and associated factors of comorbid anxiety disorders in late-life depression: findings from geriatric tertiary outpatient settings.

Neuropsychiatr Dis Treat 2019 7;15:199-204. Epub 2019 Jan 7.

Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Purpose: The study evaluated the prevalence of comorbid anxiety disorders in late-life depression (LLD) and identified their associated factors.

Patients And Methods: This study involved 190 elderly Thais with depressive disorders diagnosed according to the Mini-International Neuropsychiatric Interview (MINI). Anxiety disorders were also diagnosed by the MINI. Read More

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http://dx.doi.org/10.2147/NDT.S184585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328289PMC
January 2019
2 Reads
2.154 Impact Factor

Effectiveness of 1-year treatment with long-acting formulation of aripiprazole, haloperidol, or paliperidone in patients with schizophrenia: retrospective study in a real-world clinical setting.

Neuropsychiatr Dis Treat 2019 7;15:183-198. Epub 2019 Jan 7.

Private Accredited Psychiatric Hospital, Villa Igea, Modena, Italy.

Background: Schizophrenia is a chronic mental illness that requires lifelong antipsychotic treatment. Therapy discontinuation, often due to poor adherence, increases the risk of relapses after both first and subsequent psychotic episodes. Long-acting injectable (LAI) antipsychotic drugs (APDs) have been introduced to increase therapeutic adherence, reducing blood-level variability compared to corresponding oral preparations. Read More

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http://dx.doi.org/10.2147/NDT.S189245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328290PMC
January 2019
4 Reads

The impact of short and long sleep duration on instrumental activities of daily living among stroke survivors.

Neuropsychiatr Dis Treat 2019 4;15:177-182. Epub 2019 Jan 4.

Department of Population Health, Center for Healthful Behavior Change, NYU Langone Health, NY, New York, USA,

Objective: Stroke survivors generally have problems completing instrumental activities of daily living (IADL; eg, preparing meals, chores, taking a bath, and managing finances). However, it is unclear how stroke survivors might stave off IADL issues. Studies indicating that sleep has restorative neurological effects provide potential mechanisms to address issues with IADL. Read More

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https://www.dovepress.com/the-impact-of-short-and-long-sleep
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http://dx.doi.org/10.2147/NDT.S177527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324604PMC
January 2019
7 Reads

Risk factors for developing dementia in type 2 diabetes mellitus patients with mild cognitive impairment.

Neuropsychiatr Dis Treat 2019 3;15:167-175. Epub 2019 Jan 3.

Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania,

Background: Dementia and cognitive dysfunction have many causes. There is strong evidence that diabetes mellitus (DM) increases the risk of cognitive impairment and dementia. Optimal glycemic control, identification of diabetic risk factors, and prophylactic approach are essential in the prevention of cognitive complications. Read More

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https://www.dovepress.com/risk-factors-for-developing-dement
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http://dx.doi.org/10.2147/NDT.S189905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322491PMC
January 2019
12 Reads

Risk factors for the difficulties in general activities across the day in Chinese children and adolescents with attention-deficit/hyperactivity disorder.

Neuropsychiatr Dis Treat 2019 31;15:157-166. Epub 2018 Dec 31.

Changsha Normin Health Technology Ltd., Changsha, People's Republic of China.

Objectives: To explore the factors significantly associated with the difficulties of general activities during specific time periods across the day in Chinese children and adolescents with attention-deficit/hyperactivity disorder (ADHD).

Methods: A cross-sectional study assessing the validity and reliability of Questionnaire-Children with Difficulties (QCD) for difficulties of general activities during specific time periods of the day in 200 Chinese children and adolescents with ADHD was the data source for this post-hoc analysis. Multivariate linear regression analyses were conducted to identify the factors significantly associated with the total and subscale scores of QCD respectively. Read More

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https://www.dovepress.com/risk-factors-for-the-difficulties-
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http://dx.doi.org/10.2147/NDT.S187882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318709PMC
December 2018
5 Reads

Association between the gene and schizophrenia: an updated meta-analysis.

Neuropsychiatr Dis Treat 2019 28;15:143-155. Epub 2018 Dec 28.

School of Forensic Medicine, China Medical University, Shenyang 110122, People's Republic of China,

Background: In order to explore the association between the gene and the risk of schizophrenia, an updated meta-analysis was conducted using a total of 46 scientific articles.

Methods: Through a literature search, papers studied included 35 articles on serotonin-transporter-linked polymorphic region (5-HTTLPR) with 8,752 cases and 10,610 controls, 17 articles on second intron variable number of tandem repeats with 7,284 cases and 8,544 controls, four studies on rs1042173 with 1,351 cases and 2,101 controls, and four studies on rs140700 with 1,770 cases and 2,386 controls. Pooled, subgroup, and sensitivity analyses were performed, and the results were visualized by forest and funnel plots. Read More

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http://dx.doi.org/10.2147/NDT.S190563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314053PMC
December 2018
7 Reads

Differences in etiological beliefs about schizophrenia among patients, family, and medical staff.

Neuropsychiatr Dis Treat 2019 27;15:137-142. Epub 2018 Dec 27.

Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan,

Objectives: To determine whether etiological beliefs are different among schizophrenia patients, their family, and medical staff.

Patients And Methods: A cross-sectional study was performed at five hospitals and one mental clinic and included 212 patients, 144 family members, and 347 medical staff other than psychiatrists. A questionnaire about the possible etiological causes of schizophrenia was used. Read More

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http://dx.doi.org/10.2147/NDT.S185483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311336PMC
December 2018
5 Reads

Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis.

Neuropsychiatr Dis Treat 2019 27;15:127-135. Epub 2018 Dec 27.

Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Traumatic brain injury (TBI) remains a main public health problem being associated with high mortality and morbidity. The functional outcome of TBI remains unfavorable despite several surgical and medical therapies. Cerebrolysin is a neuropeptide with potential neuroregenerative entities. Read More

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http://dx.doi.org/10.2147/NDT.S186865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311329PMC
December 2018

Frequent attenders in general medical practice in Italy: a preliminary report on clinical variables related to low functioning.

Neuropsychiatr Dis Treat 2019 24;15:115-125. Epub 2018 Dec 24.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy,

Background: Frequent attenders (FAs), defined as patients reporting a disproportionate number of visits to general practitioners (GPs), may represent up to one-third of GP patients responsible for a high burden of care not always justified by the severity of the medical condition. The aim of this study was to explore sociodemographic and clinical characteristics of FAs of GP in Italy with particular attention to functional impairment.

Methods: A total sample of 75 FAs (defined as individuals who had consulted GPs 15 times or more during 2015) of GPs of three primary care centers (Pisa, Livorno, and Lucca) in Italy were enrolled and assessed by sociodemographic scale, Structured Clinical Interview for (SCID-5), global functioning (Global Assessment of Functioning [GAF]), illness behavior and perceived health (Illness Behavior Inventory), and somatic comorbidity (Cumulative Illness Rating Scale). Read More

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http://dx.doi.org/10.2147/NDT.S179013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309017PMC
December 2018
2 Reads
2.154 Impact Factor

A literature-based algorithm for the assessment, management, and monitoring of drug-induced QTc prolongation in the psychiatric population.

Authors:
M Zolezzi L Cheung

Neuropsychiatr Dis Treat 2019 24;15:105-114. Epub 2018 Dec 24.

Pharmacy Department, Grey Nuns Community Hospital, Edmonton, AB, Canada.

Background: Certain psychotropics and a number of other medications used to treat medical conditions in psychiatric patients can increase the risk of prolonging the corrected QT (QTc) interval on the electrocardiogram, which puts patients at risk of life-threatening ventricular arrhythmias such as torsades de pointes. Pharmacists are often consulted about medications which are known to prolong the QTc interval. Although this information is often accessible, advising how to identify, assess, manage, and refer psychiatric patients at risk for drug-induced QTc prolongation is more challenging. Read More

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http://dx.doi.org/10.2147/NDT.S186474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309020PMC
December 2018
1 Read

Poststroke epilepsy: current perspectives on diagnosis and treatment.

Neuropsychiatr Dis Treat 2019 24;15:95-103. Epub 2018 Dec 24.

Department of Paediatric Neurology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.

Seizures and epilepsy are quite a common outcome of arterial ischemic stroke (AIS) both in pediatric and adult patients, with distinctly higher occurrence in children. These poststroke consequences affect patients' lives, often causing disability. Poststroke seizure (PSS) may also increase mortality in patients with AIS. Read More

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http://dx.doi.org/10.2147/NDT.S169579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309019PMC
December 2018

Associations of polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test.

Neuropsychiatr Dis Treat 2019 24;15:83-94. Epub 2018 Dec 24.

Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea,

Background: Alcohol dependence (AD) is a common disorder that is influenced by genetic as well as environmental factors. A previous genome-wide association study (GWAS) of the Korean population performed by our research group identified a number of genes, including () and (), as novel genetic markers of AD.

Methods: The present investigation was a fine-mapping follow-up study of 459 AD and 455 non-AD subjects of Korean descent to determine the associations between and polymorphisms and AD. Read More

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https://www.dovepress.com/associations-of-brap-polymorphisms
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http://dx.doi.org/10.2147/NDT.S184067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309135PMC
December 2018
4 Reads

Intrinsic thalamocortical connectivity varies in the age of onset subtypes in major depressive disorder.

Neuropsychiatr Dis Treat 2019 21;15:75-82. Epub 2018 Dec 21.

Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada,

Background: Differences in the thalamocortical system have been shown in patients with major depressive disorder (MDD). Given prior evidence of phenotypic heterogeneity by the age of onset in MDD, we examined whether differences in thalamocortical connectivity could identify biological subtypes of MDD defined by the age of illness onset.

Methods: A total of 94 subjects including 20 early-onset (EO) MDD (onset, 18 years), 34 adult-onset (AO) MDD, and 40 healthy controls (HCs) underwent resting-state functional MRI. Read More

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https://www.dovepress.com/intrinsic-thalamocortical-connecti
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http://dx.doi.org/10.2147/NDT.S184425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306066PMC
December 2018
8 Reads

Treatment of acute thromboembolic complication after stent-assisted coil embolization of ruptured intracranial aneurysm: a case report.

Neuropsychiatr Dis Treat 2019 21;15:69-74. Epub 2018 Dec 21.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun 130021, China,

A 45-year-old Chinese man presented with acute severe headache for 2 days. He was diagnosed as subarachnoid hemorrhage. Head CT and subsequent head digital subtraction angiography (DSA) showed left internal carotid artery (ICA) aneurysm in the supraclinoid segment. Read More

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http://dx.doi.org/10.2147/NDT.S184372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306058PMC
December 2018
6 Reads

The factor structure, reliability and validity of the Chinese version of the Van Dream Anxiety Scale.

Neuropsychiatr Dis Treat 2019 21;15:57-67. Epub 2018 Dec 21.

Department of Clinical Psychology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China,

Background/purpose: Dream emotions and contents are associated with psychological well-being. Dream disturbances, such as frequent nightmares and dream anxiety, are associated with a variety of psychopathological conditions. Therefore, it is important to consider nightmares and the resulting dream anxiety. Read More

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http://dx.doi.org/10.2147/NDT.S192891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306070PMC
December 2018

Association between rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects.

Neuropsychiatr Dis Treat 2019 21;15:47-55. Epub 2018 Dec 21.

Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China,

Introduction: Previous epidemiological studies have suggested that rs2569190 C>T polymorphism plays an important role in ischemic stroke (IS) risk, but the results were inconsistent. Therefore, we conducted a meta-analysis to determine the association between rs2569190 C>T polymorphism and IS susceptibility.

Methods: Online databases were searched from inception up to July 1, 2018, for studies concerning rs2569190 C>T polymorphism and its association with IS susceptibility. Read More

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http://dx.doi.org/10.2147/NDT.S185313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306072PMC
December 2018

Adjunctive brexpiprazole in patients with major depressive disorder and anxiety symptoms: post hoc analyses of three placebo-controlled studies.

Neuropsychiatr Dis Treat 2019 20;15:37-45. Epub 2018 Dec 20.

Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, Canada.

Objective: Episodes of major depressive disorder (MDD) characterized by high levels of anxiety symptoms are less likely to respond to some forms of antidepressant treatment (ADT). This report examines the effects of adjunctive brexpiprazole on depressive symptoms among patients with MDD and anxiety symptoms.

Materials And Methods: This was a post hoc analysis of 1,171 patients from the 6-week, randomized, double-blind phases of three studies in adults with MDD and inadequate response to ADTs (NCT01360645, NCT01360632, NCT02196506). Read More

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http://dx.doi.org/10.2147/NDT.S185815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305164PMC
December 2018
3 Reads

Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm.

Neuropsychiatr Dis Treat 2019 19;15:33-36. Epub 2018 Dec 19.

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China,

Objective: To explore the efficacy of botulinum toxin type A (BTX-A) therapy in relieving anxiety and depression in patients with hemifacial spasm (HFS) and benign essential blepharospasm (BEB).

Patients And Method: Ninety idiopathic HFS patients and 90 BEB patients were enrolled. The anxiety and depression status were evaluated by self-rating anxiety scale (SAS) and self-rating depression scale (SDS), respectively, before and after the injection of BTX-A. Read More

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http://dx.doi.org/10.2147/NDT.S181820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304258PMC
December 2018

Influence of Xiaoyaosan on depressive-like behaviors in chronic stress-depressed rats through regulating tryptophan metabolism in hippocampus.

Neuropsychiatr Dis Treat 2019 18;15:21-31. Epub 2018 Dec 18.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China,

Background: Tryptophan metabolism has always been considered to play a vital role in mental disorder diseases, and how traditional Chinese formula Xiaoyaosan regulates the tryptophan metabolism is a complement to the pathogenesis of depression. This study established a depression rat model by the chronic immobilization stress (CIS) method and observed the change in tryptophan metabolism in hippocampus and the effects of Xiaoyaosan.

Methods: Forty-eight male Sprague Dawley (SD) rats were randomly divided into the following four groups: control group, CIS group, Xiaoyaosan group, and fluoxetine group. Read More

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http://dx.doi.org/10.2147/NDT.S185295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302818PMC
December 2018

Levetiracetam for epilepsy: an evidence map of efficacy, safety and economic profiles.

Neuropsychiatr Dis Treat 2019 17;15:1-19. Epub 2018 Dec 17.

Department of Pharmacy, Peking University Third Hospital, Beijing, China,

Objective: To evaluate the efficacy, safety and economics of levetiracetam (LEV) for epilepsy.

Materials And Methods: PubMed, Scopus, the Cochrane Library, OpenGrey.eu and ClinicalTrials. Read More

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https://www.dovepress.com/levetiracetam-for-epilepsy-an-evid
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http://dx.doi.org/10.2147/NDT.S181886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301299PMC
December 2018
12 Reads

Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia.

Neuropsychiatr Dis Treat 2018 13;14:3393-3403. Epub 2018 Dec 13.

Department of Forensic Medicine, Chongqing Medical University, Chongqing, China,

To investigate the autoimmune mechanisms of schizophrenia, we explored the relationship between schizophrenia and cancer using gene expression data of peripheral blood mononuclear cells from GSE27383 datasets. Gene screening and enrichment analysis using Gene Set Enrichment Analysis were applied to identify possible connections between schizophrenia and cancer. Real-time PCR (quantitative PCR), Western blotting and immunohistochemistry were performed on the brain tissue from both schizophrenia patients and normal controls. Read More

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http://dx.doi.org/10.2147/NDT.S188210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298395PMC
December 2018
2 Reads

Jian-Pi-Zhi-Dong-Decoction regulates the expression of glutamate transporters to attenuate glutamate excitotoxicity and exerts anti-tics effects in Tourette syndrome model rats.

Neuropsychiatr Dis Treat 2018 17;14:3381-3392. Epub 2018 Dec 17.

Department of Pediatrics, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China,

Purpose: This study explored whether Jian-Pi-Zhi-Dong-Decoction (JPZDD) could regulate the metabolism of glutamate (GLU) and its transporters in the striatum to exert anti-tics effects in Tourette syndrome (TS) rats.

Materials And Methods: We randomly assigned 56 Sprague Dawley rats into four groups, each with 14 rats: control, model, tiapride (Tia), and JPZDD. TS groups (model, Tia, and JPZDD) received intraperitoneal injection of 3,3'-iminodipropionitrile for 7 days to establish TS model. Read More

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https://www.dovepress.com/jian-pi-zhi-dong-decoction-regulat
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http://dx.doi.org/10.2147/NDT.S185169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301307PMC
December 2018
2 Reads
2.154 Impact Factor

Influence of olanzapine on serum prolactin levels and BMI in female patients with schizophrenia.

Neuropsychiatr Dis Treat 2018 13;14:3373-3379. Epub 2018 Dec 13.

Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China,

Objectives: It has been well documented that elevation of serum prolactin (PRL) level and weight gain are common in patients receiving treatment with atypical antipsychotics. The existing evidences show that serum PRL is elevated in schizophrenic patients treated with olanzapine. However, little is known about the long-term effects of olanzapine on PRL levels and weight gain in female patients with schizophrenia. Read More

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https://www.dovepress.com/influence-of-olanzapine-on-serum-p
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http://dx.doi.org/10.2147/NDT.S180303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298388PMC
December 2018
10 Reads
2.154 Impact Factor

Cognitive dysfunction and negative symptoms in patients with schizophrenia and their first-degree relatives from simplex and multiplex families.

Neuropsychiatr Dis Treat 2018 5;14:3339-3348. Epub 2018 Dec 5.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China,

Purpose: This study aimed to investigate cognitive functioning, negative symptoms, and the relationships in schizophrenia (SP) pedigrees and to explore the effect of genetic loading on those endophenotypes.

Patients And Methods: Forty-four patients with SP, 81 first-degree non-psychotic relatives of patients from simplex and multiplex families, 14 matched control probands, and 29 first-degree relatives of the patients from communities were assessed by the vocabulary subtest (VS) of Wechsler Adult Intelligence Scale, memory span subtests of the Multiple Memory Assessment Scale (MMAS), Wisconsin Card Sorting Test (WCST), Continuous Performance Test (CPT), and Negative Scale of Positive and Negative Syndrome Scale.

Results: Compared with controls, patients with SP and their relatives had worse performances in WCST and CPT, and more serious negative symptoms. Read More

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https://www.dovepress.com/cognitive-dysfunction-and-negative
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http://dx.doi.org/10.2147/NDT.S179534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287416PMC
December 2018
7 Reads

Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder.

Neuropsychiatr Dis Treat 2018 3;14:3329-3337. Epub 2018 Dec 3.

National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China,

Background: Gut microbiota can affect human behavior and mood in many ways. Several studies have shown that patients with depression were also accompanied with gut microbiota disorder, in which Firmicutes are related to the protective function of intestinal barrier. In this study, we explore the changes and effects of Firmicutes in the patients with major depressive disorder (MDD). Read More

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http://dx.doi.org/10.2147/NDT.S188340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284853PMC
December 2018
1 Read

Altered functional connectivity of primary visual cortex in late blindness.

Neuropsychiatr Dis Treat 2018 3;14:3317-3327. Epub 2018 Dec 3.

Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China,

Background: Previous studies demonstrated that early blindness is associated with abnormal intrinsic functional connectivity (FC) between the primary visual cortex (V1) and other sensory areas. However, the V1 pattern of spontaneous neural activity occurring in late blindness (LB) remains unknown. The purpose of this study was to investigate the intrinsic FC patterns of V1 in LB. Read More

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http://dx.doi.org/10.2147/NDT.S183751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284854PMC
December 2018
7 Reads

Sensory function in cluster headache: an observational study comparing the symptomatic and asymptomatic sides.

Neuropsychiatr Dis Treat 2018 10;14:3363-3371. Epub 2018 Dec 10.

Cognitive Motor Neuroscience Group, Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK.

Background: Based on inconsistent sensory alterations demonstrated in cluster headache (CH), the aim of this study was to determine whether patients with CH develop sensory changes in the symptomatic side compared to the asymptomatic side.

Methods: Quantitative sensory testing (QST), including pressure pain threshold (PPT), tactile detection threshold (TDT), prick detection threshold (PDT), and two-point detection threshold (2PDT), was evaluated in 16 patients (seven women; age 41.9±6. Read More

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http://dx.doi.org/10.2147/NDT.S186051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292232PMC
December 2018
3 Reads

Effectiveness of parent training in improving stress-coping capability, anxiety, and depression in mothers raising children with autism spectrum disorder.

Neuropsychiatr Dis Treat 2018 7;14:3355-3362. Epub 2018 Dec 7.

Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan,

Purpose: Raising a child with autism spectrum disorder (ASD) can be a stressor, and mothers of ASD children often present with high levels of stress and depression. Interventional steps to enhance parental coping skills and resiliency are more important for parental mental health and the family-centered care of children with ASD than merely reducing parental stress. Although the importance of stress-coping skills is well established, only a few studies have investigated interventional steps to improve parental coping or resiliency. Read More

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http://dx.doi.org/10.2147/NDT.S188387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292242PMC
December 2018