8,176 results match your criteria Neuroprotective Agents in Stroke


Combination therapy of the granulocyte colony stimulating factor and intravenous lipid emulsion protect the hippocampus after global ischemia in rat: focusing on CA1 region.

Metab Brain Dis 2020 May 26. Epub 2020 May 26.

Department of Basic Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Brain stroke is one of the causes of human death and disability worldwide. Global ischemia results in the accumulation of free radicals in the neurons. It leads to histologically brain damage. Read More

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http://dx.doi.org/10.1007/s11011-020-00579-2DOI Listing

Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model.

Int J Mol Sci 2020 May 24;21(10). Epub 2020 May 24.

Department of Medical Science, Chungnam National University, Daejeon 35015, Korea.

Neonatal ischemic stroke has a higher incidence than childhood stroke. Seizures are the first sign for the need for clinical assessment in neonates, but many questions remain regarding treatments and follow-up modalities. In the absence of a known pathophysiological mechanism, only supportive care is currently provided. Read More

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http://dx.doi.org/10.3390/ijms21103703DOI Listing

Intra-arterial neuroprotective therapy as an adjunct to endovascular intervention in acute ischemic stroke: A review of the literature and future directions.

Interv Neuroradiol 2020 May 19:1591019920925677. Epub 2020 May 19.

Department of Neurology, Weill Cornell Medical Institution New York Presbyterian Hospital, New York, NY, USA.

Mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion has been shown to significantly improve outcomes. However, despite efficient rates of recanalization (60-90%), the rates of functional independence remain suboptimal (14-58%), most likely due to pathways of cell death in the brain that have already committed despite successful reperfusion. Pharmacologic neuroprotection provides a potential means of preventing this inevitable damage through targeting excitotoxicity, reactive oxygen species, cellular apoptosis, and inflammation. Read More

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http://dx.doi.org/10.1177/1591019920925677DOI Listing

Tyrosol as a neuroprotector: strong effects of a "weak" antioxidant.

Curr Neuropharmacol 2020 May 6. Epub 2020 May 6.

Siberian State Medical University, Tomsk. Russian Federation.

The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biophenol, is present in a variety of natural sources, mainly in foods, such as olive oil and wine. Read More

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http://dx.doi.org/10.2174/1570159X18666200507082311DOI Listing

Design, synthesis, and biological evaluation of novel stachydrine derivatives as potent neuroprotective agents for cerebral ischemic stroke.

Naunyn Schmiedebergs Arch Pharmacol 2020 May 5. Epub 2020 May 5.

School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.

Stachydrine is a natural product with multiple protective biological activities, including those involved in preventing cancer, ischemia, and cardiovascular disease. However, its use has been limited by low bioavailability and unsatisfactory efficacy. To address this problem, a series of stachydrine derivatives (A1/A2/A3/A4/B1/B2/B3/B4) were designed and synthesized, and biological studies were carried out in vitro and in vivo. Read More

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http://dx.doi.org/10.1007/s00210-020-01868-4DOI Listing
May 2020
2.471 Impact Factor

Ciprofloxacin-rasagiline drug interaction leading to dopaminergic effects.

Nurse Pract 2020 05;45(5):11-12

Kathryn B. Chappell is a clinical pharmacist, internal medicine at CHRISTUS Trinity Mother Frances Hospital, Tyler, Tex. Samarth P. Shah is a clinical pharmacy specialist, internal medicine/acute stroke at Methodist University Hospital, Memphis, Tenn. B. Tate Cutshall is a clinical pharmacy specialist, internal medicine at Methodist University Hospital, Memphis, Tenn. Christopher W. Sands is a hospitalist at Methodist University Hospital, Memphis, Tenn., and an assistant professor at the University of Tennessee Health Science Center, Memphis, Tenn.

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http://dx.doi.org/10.1097/01.NPR.0000660368.67226.adDOI Listing

Neuroprotective Effects of Emodin against Ischemia/Reperfusion Injury through Activating ERK-1/2 Signaling Pathway.

Int J Mol Sci 2020 Apr 21;21(8). Epub 2020 Apr 21.

Center for Neurotrauma and Neuroregeneration, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan.

Background: Stroke is one of the leading causes of death and disability worldwide and places a heavy burden on the economy in our society. Current treatments, such as the use of thrombolytic agents, are often limited by a narrow therapeutic time window. However, the regeneration of the brain after damage is still active days, even weeks, after stroke occurs, which might provide a second window for treatment. Read More

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http://dx.doi.org/10.3390/ijms21082899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215870PMC

The impact of single and combined PPAR-α and PPAR-γ activation on the neurological outcomes following cerebral ischemia reperfusion.

Life Sci 2020 Jul 20;252:117679. Epub 2020 Apr 20.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Egypt.

Aim: The neuronal damage and accompanied functional deficits induced by cerebral ischemia are among the most common causes of disabilities in adults. Activation of subtypes of peroxisome proliferator-activated receptors (PPARs); PPAR-α and PPAR-γ have shown neuroprotective effects in different neurodegenerative diseases including stroke. Thus, this study aimed to compare the effects of two different agonists: PPAR-α (fenofibrate) and PPAR-γ (pioglitazone) as well as the effect of their combination in ameliorating post-ischemia behavioral deficits. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117679DOI Listing

[Lithium ascorbate as a cerebroprotective agent in a model of ischemic stroke].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(3. Vyp. 2):29-32

National Research Tomsk Polytechnic University, Research School of Chemical and Biomedical Technologies, Tomsk, Russia.

Introduction: Ischemic stroke is one of the most severe neurological pathologies with high mortality and disability. In this connection, the development and study of new drugs for the prevention and treatment of stroke is an extremely important task. A new approach to neuroprotection is the use of lithium salts with antioxidant activity. Read More

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http://dx.doi.org/10.17116/jnevro202012003229DOI Listing

Antithrombin gamma attenuates macrophage/microglial activation and brain damage after transient focal cerebral ischemia in mice.

Life Sci 2020 Jul 17;252:117665. Epub 2020 Apr 17.

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

Aims: Thrombin formation is increased in patients with acute cerebral ischemic stroke, and augments coagulation and inflammation in the brain. Administration of antithrombin (AT) was previously reported to be protective against renal and myocardial ischemic injury. Thus, we hypothesized that treatment with AT would be neuroprotective against cerebral ischemic injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117665DOI Listing

Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke.

Antioxidants (Basel) 2020 Mar 31;9(4). Epub 2020 Mar 31.

Department of Research, IRYCIS, Hospital Ramón y Cajal, Ctra. Colmenar km 9.1, 28034 Madrid, Spain.

Nitrones have a well-recognized capacity as spin-traps and are considered powerful free radical scavengers, which are two important issues in hypoxia-induced oxidative stress and cell death in brain ischemia. Consequently, nitrones have been proposed as therapeutic agents in acute ischemic stroke (AIS). In this paper, we update the biological and pharmacological characterization of ISQ-201, a previously identified cholesteronitrone hybrid with antioxidant and neuroprotective activity. Read More

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http://dx.doi.org/10.3390/antiox9040291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222207PMC

Regio- and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants.

Angew Chem Int Ed Engl 2020 Apr 3. Epub 2020 Apr 3.

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Muelheim, Germany.

Steroidal C7β alcohols and their respective esters have shown significant promise as neuroprotective and anti-inflammatory agents to treat chronic neuronal damage like stroke, brain trauma, and cerebral ischemia. Since C7 is spatially far away from any functional groups that could direct C-H activation, these transformations are not readily accessible using modern synthetic organic techniques. Reported here are P450-BM3 mutants that catalyze the oxidative hydroxylation of six different steroids with pronounced C7 regioselectivities and β stereoselectivities, as well as high activities. Read More

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http://dx.doi.org/10.1002/anie.202003139DOI Listing

[Advances in research on pharmacological and neuroprotective effects of traditional Chinese medicine after cerebral ischemia].

Zhongguo Zhong Yao Za Zhi 2020 Feb;45(3):513-517

Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.

Cerebral ischemia is also known as ischemic stroke. In recent years, research on neuroprotection after ischemia has became a hot spot as stroke can result in symptoms of nerve damages such as hemiplegia, learning and memory disorders. The key factors that cause the death of cells include excitotoxicity, oxidative damage, nitrosative stress and inflammation. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191022.403DOI Listing
February 2020

Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury.

Front Mol Neurosci 2020 5;13:28. Epub 2020 Mar 5.

Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

The cerebral ischemia injury can result in neuronal death and/or functional impairment, which leads to further damage and dysfunction after recovery of blood supply. Cerebral ischemia/reperfusion injury (CIRI) often causes irreversible brain damage and neuronal injury and death, which involves many complex pathological processes including oxidative stress, amino acid toxicity, the release of endogenous substances, inflammation and apoptosis. Oxidative stress and inflammation are interactive and play critical roles in ischemia/reperfusion injury in the brain. Read More

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http://dx.doi.org/10.3389/fnmol.2020.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066113PMC

Protective Effects and Mechanisms of Action of Ulinastatin against Cerebral Ischemia-Reperfusion Injury.

Curr Pharm Des 2020 03 2. Epub 2020 Mar 2.

Emergency Department, First Hospital of Jilin University, China.

Background: Cerebral ischemia-reperfusion injury is an extremely complicated pathological process that is clinically characterized by high rates of disability and mortality. It is imperative to explore some effective neuroprotective agents for treatment of cerebral ischemia-reperfusion injury. Ulinastatin is a protease inhibitor, with anti-inflammatory and antioxidant activity. Read More

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http://dx.doi.org/10.2174/1381612826666200303114955DOI Listing

Neutrophil-Related Oxidants Drive Heart and Brain Remodeling After Ischemia/Reperfusion Injury.

Front Physiol 2019 4;10:1587. Epub 2020 Feb 4.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, Genoa, Italy.

The inflammatory response associated with myocardial and brain ischemia/reperfusion injury (IRI) is a critical determinant of tissue necrosis, functional organ recovery, and long-term clinical outcomes. In the post-ischemic period, reactive oxygen species (ROS) are involved in tissue repair through the clearance of dead cells and cellular debris. Neutrophils play a critical role in redox signaling due to their early recruitment and the large variety of released ROS. Read More

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http://dx.doi.org/10.3389/fphys.2019.01587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010855PMC
February 2020

Recanalization following Endovascular treatment and imaging of PErfusion, Regional inFarction and atrophy to Understand Stroke Evolution-NA1 (REPERFUSE-NA1).

Int J Stroke 2020 Apr 1;15(3):343-349. Epub 2020 Mar 1.

Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, Canada.

Rationale: Following endovascular treatment, poor clinical outcomes are more frequent if the initial infarct core or volume of irreversible brain damage is large. Clinical outcomes may be improved using neuroprotective agents that reduce stroke volume and improve recovery.

Aim: The aim of the REPERFUSE NA1 was to replicate the preclinical neuroprotection study that significantly reduced infarct volume in a primate model of ischemia reperfusion. Read More

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http://dx.doi.org/10.1177/1747493019895666DOI Listing

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.

Lancet 2020 03 20;395(10227):878-887. Epub 2020 Feb 20.

NoNO, Toronto, ON, Canada.

Background: Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke.

Methods: For this multicentre, double-blind, randomised, placebo-controlled study done in 48 acute care hospitals in eight countries, we enrolled patients with acute ischaemic stroke due to large vessel occlusion within a 12 h treatment window. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)30258-0DOI Listing
March 2020
45.217 Impact Factor

Edaravone reduces depression severity in patients with symptomatic intracranial stenosis and is associated with the serum expression of sex hormones.

Medicine (Baltimore) 2020 Feb;99(8):e19316

Institute of Neuropsychiatry and Mental Health Center.

Objective: To investigate the effect of edaravone on depression relief in symptomatic patients with intracranial stenosis and its relationship with the expression of sex hormones.

Methods: We recruited 112 patients with symptomatic intracranial arterial stenosis from Renmin Hospital, Wuhan University, between October 2014 and October 2017. All patients were divided into the traditional or experimental (traditional treatment + intravenous infusion of edaravone 30 mg twice a day for 14 days) treatment groups. Read More

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http://dx.doi.org/10.1097/MD.0000000000019316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034658PMC
February 2020

Shengui Sansheng Pulvis maintains blood-brain barrier integrity by vasoactive intestinal peptide after ischemic stroke.

Phytomedicine 2020 Feb 23;67:153158. Epub 2019 Dec 23.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa 999078, Macao. Electronic address:

Background Shengui Sansheng Pulvis (SSP) has about 300 years history used for stroke treatment, and evidences suggest it has beneficial effects on neuro-angiogenesis and cerebral energy metabolic amelioration post-stroke. However, its protective action and mechanisms on blood-brain barrier (BBB) is still unknown. Purpose Based on multiple neuroprotective properties of vasoactive intestinal peptide (VIP) in neurological disorders, we investigate if SSP maintaining BBB integrity is associated with VIP pathway in rat permanent middle cerebral artery occlusion (MCAo) model. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.153158DOI Listing
February 2020
3.126 Impact Factor

Treadmill exercise improves neurological function by inhibiting autophagy and the binding of HMGB1 to Beclin1 in MCAO juvenile rats.

Life Sci 2020 Feb 8;243:117279. Epub 2020 Jan 8.

Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China. Electronic address:

Aims: Treadmill exercise is a beneficial treatment following childhood stroke. Thus, studies focusing on the neuroprotective mechanism of exercise training during postischemic treatment in children with ischemic stroke are urgently needed. We evaluated the effects of treadmill exercise on autophagy after cerebral ischemia in young rats. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117279DOI Listing
February 2020

Development of Novel -hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents.

J Med Chem 2020 Feb 22;63(3):1051-1067. Epub 2020 Jan 22.

State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , 130 Mei Long Road , Shanghai 200237 , China.

Our previous study had identified ciclopirox (CPX) as a promising lead compound for treatment of ischemic stroke. To find better neuroprotective agents, a series of -hydroxypyridone derivatives based on CPX were designed, synthesized, and evaluated in this study. Among these derivatives, compound exhibits significant neuroprotection against oxygen glucose deprivation and oxidative stress-induced injuries in neuronal cells. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b01338DOI Listing
February 2020
5.447 Impact Factor

Modelling heme-mediated brain injury associated with cerebral malaria in human brain cortical organoids.

Sci Rep 2019 12 16;9(1):19162. Epub 2019 Dec 16.

Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr, Atlanta, GA, 30310, USA.

Human cerebral malaria (HCM), a severe encephalopathy associated with Plasmodium falciparum infection, has a 20-30% mortality rate and predominantly affects African children. The mechanisms mediating HCM-associated brain injury are difficult to study in human subjects, highlighting the urgent need for non-invasive ex vivo human models. HCM elevates the systemic levels of free heme, which damages the blood-brain barrier and neurons in distinct regions of the brain. Read More

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http://dx.doi.org/10.1038/s41598-019-55631-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914785PMC
December 2019

Efficacy of Neuroprotective Drugs in Acute Ischemic Stroke: Is It Helpful?

J Neurosci Rural Pract 2019 Oct 11;10(4):576-581. Epub 2019 Dec 11.

Department of Neurology, Ramaiah Medical College and Hospital, Bengaluru, Karnataka, India.

Out of several neuroprotective drugs (NPDs) studied in animals and humans, four NPDs (citicoline, edaravone, cerebrolysin, and minocycline) have been found to have beneficial effects in acute ischemic stroke (AIS). The purpose is to evaluate the efficacy of citicoline, edaravone, minocycline, and cerebrolysin compared with placebo in patients with middle cerebral artery (MCA) territory AIS. This was a prospective, single center, single-blinded, and hospital-based study. Read More

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http://dx.doi.org/10.1055/s-0039-1700790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906097PMC
October 2019

Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract of and in Metabolic Syndrome Rats.

Oxid Med Cell Longev 2019 11;2019:9658267. Epub 2019 Nov 11.

Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

The novel strategy against ischemic stroke in metabolic syndrome (MetS) targeting at oxidative stress and inflammation has gained attention due to the limitation of the current therapy. Due to the antioxidant and anti-inflammation of the combined extract of and , the cerebroprotective effect against cerebral ischemia in MetS condition has been focused. Since no data were available, this study was set up to determine the effects of the combined extract of L. Read More

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http://dx.doi.org/10.1155/2019/9658267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885298PMC

Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function.

Oxid Med Cell Longev 2019 11;2019:7850154. Epub 2019 Nov 11.

Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China.

Leonurine, also named SCM-198, which was extracted from , displayed a protective effect on various cardiovascular and brain diseases, like ischemic stroke. Ischemic stroke which is the leading cause of morbidity and mortality, ultimately caused irreversible neuron damage. This study is aimed at exploring the possible therapeutic potential of SCM-198 in the protection against postischemic neuronal injury and possible underlying mechanisms. Read More

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http://dx.doi.org/10.1155/2019/7850154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885260PMC

[Possibilities of neurotrophic therapy in early recovery after stroke].

Authors:
A N Bogolepova

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(8. Vyp. 2):84-89

Pirogov Russian National Research Medical University, Moscow, Russia.

The high prevalence and disability of patients with ischemic stroke make the further development of the rehabilitation system relevant. The implementation of neuroplasticity mechanisms is largely provided by neurotrophic factors. One of the most well-known neurotrophic drugs is cerebrolysin, the efficacy of which in patients with stroke has been confirmed in many clinical studies. Read More

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http://dx.doi.org/10.17116/jnevro201911908284DOI Listing
January 2020

Idiopathic hypereosinophilic syndrome presenting as monoplegia.

BMJ Case Rep 2019 Dec 8;12(12). Epub 2019 Dec 8.

Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Idiopathic hypereosinophilic syndrome (IHES) is a rare disorder. It is characterised by persistent eosinophilia with eosinophil mediated tissue infiltration and organ dysfunction. Clinical features of IHES vary widely, as it may present with dermatological, pulmonary, gastrointestinal, cardiac or neurological symptoms. Read More

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http://dx.doi.org/10.1136/bcr-2019-232889DOI Listing
December 2019

[Comparative studies of neurotrophic drugs based on brain hydrolysates].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(10):134-140

Institute of Macroheterocyclic Compounds, Ivanovo State University of Chemistry and Technology, 153000 Ivanovo, Russia; Russian Research Institute of Physiology, Biochemistry and Animal Nutrition, Borovsk, Russia.

The results of the analysis of comparative studies of neurotrophic drugs based on brain hydrolysates (BH) are presented. The most comprehensive comparative study of the BH drugs carried out by Zhang, et al. 2019 investigated the effects of four drugs (cognistar, cerebrolysate, cortexin, cerebrolysin) on a model of ischemic stroke in rats. Read More

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http://dx.doi.org/10.17116/jnevro2019119101134DOI Listing
December 2019
4 Reads

Young male with syphilitic cerebral arteritis presents with signs of acute progressive stroke: A case report.

Medicine (Baltimore) 2019 Nov;98(48):e18147

Hospital of Chengdu University of Traditional Chinese Medicine.

Introduction: Neurosyphilis is a chronic infection of the central nervous system that is commonly found in adult with long latency periods. Neurosyphilis-attributed deaths in young patients have grown exponentially in the past decade, yet there have been few studies on the early stages of neurosyphilis.

Patient Concerns: A young male patient with syphilitic cerebral arteritis was evaluated in our clinic for the clinical signs of progressive ischemic stroke. Read More

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http://dx.doi.org/10.1097/MD.0000000000018147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890281PMC
November 2019

Biochanin A Provides Neuroprotection Against Cerebral Ischemia/Reperfusion Injury by Nrf2-Mediated Inhibition of Oxidative Stress and Inflammation Signaling Pathway in Rats.

Med Sci Monit 2019 Nov 26;25:8975-8983. Epub 2019 Nov 26.

Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China (mainland).

BACKGROUND Oxidative stress and neuroinflammation are 2 pivotal mechanisms in the progression of cerebral ischemia/reperfusion injury. Biochanin A, a natural phytoestrogen, has been reported to protect against ischemic brain injury in animal experiments, but the possible pharmacological mechanisms of its neuroprotection remain elusive. In this research, we sought to investigate the neuroprotective effects of biochanin A in experimental stroke rats and the probable mechanisms underlying oxidative stress and inflammation signaling pathways. Read More

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http://dx.doi.org/10.12659/MSM.918665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896748PMC
November 2019

Neurosarcoidosis presenting with a partial Claude syndrome.

BMJ Case Rep 2019 Nov 19;12(11). Epub 2019 Nov 19.

Neurology, North Middlesex University Hospital NHS Trust, London, UK.

Neurosarcoidosis when encountered by neurologists most commonly presents as cranial neuropathy, peripheral mononeuropathy,polyneuropathy, myopathy, meningitis or myelopathy. There are limited reports in the current literature on the cases of neurosarcoidosis patients presenting with ischaemic stroke. We discuss a 52-year-old patient with a known previous history of cutaneous sarcoidosis presenting with an acute third nerve palsy, facial weakness and ataxia. Read More

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http://dx.doi.org/10.1136/bcr-2019-232317DOI Listing
November 2019

Neuroprotective effect of Convolvulus pluricaulis Choisy in oxidative stress model of cerebral ischemia reperfusion injury and assessment of MAP2 in rats.

J Ethnopharmacol 2020 Mar 16;249:112393. Epub 2019 Nov 16.

Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, B.V.V.S Campus, Bagalkot, Karnataka, India.

Ethnopharmacological Relevance: Convolvulus pluricaulis Choisy commonly known as Shankhapushpi, is traditionally prescribed for nerve debility, loss of memory, epilepsy and as nervine tonic. Plant also proved to have diverse pharmacological activity but the neuroprotection in ischemic stroke were not found.

Aim Of The Study: To investigate the effect of Convolvulus pluricaulis against bilateral common carotid artery (BCCA) occlusion induced cerebral ischemic reperfusion injury. Read More

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http://dx.doi.org/10.1016/j.jep.2019.112393DOI Listing

Ligusticum chuanxiong exerts neuroprotection by promoting adult neurogenesis and inhibiting inflammation in the hippocampus of ME cerebral ischemia rats.

J Ethnopharmacol 2020 Mar 12;249:112385. Epub 2019 Nov 12.

Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

Ethnopharmacological Relevance: Cerebral ischemia, also known as stroke, can stimulate the proliferation and migration of endogenous neural stem cells (NSC) in subventricular zone of the lateral ventricle and subgranularzone of the dentate gyrus in the adult hippocampus as a defense response to damage. However, the proliferation of endogenous NSC is insufficient for central nervous system repair. Neurogenesis and anti-neuroinflammation are two important aspects for neuroprotection. Read More

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http://dx.doi.org/10.1016/j.jep.2019.112385DOI Listing

A Case of Wallenberg's Syndrome Presenting with Spontaneous Thrombosis of a Vertebral Artery Aneurysm.

J Stroke Cerebrovasc Dis 2020 Jan 11;29(1):104492. Epub 2019 Nov 11.

Department of Neurosurgery, Hiratsuka City Hospital, Hiratsuka, Kanagawa, Japan.

Complete spontaneous thrombosis of intracranial aneurysms is uncommon. Although this type of thrombosis is largely asymptomatic, in rare cases it can be accompanied by parent artery occlusion and ischemic stroke. There are limited reports of complete thrombosis of an unruptured aneurysm of the internal carotid artery and middle cerebral artery. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104492DOI Listing
January 2020

Gastrodin Attenuates Neuronal Apoptosis and Neurological Deficits after Experimental Intracerebral Hemorrhage.

J Stroke Cerebrovasc Dis 2020 Jan 11;29(1):104483. Epub 2019 Nov 11.

Department of neurosurgery, Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, People's Republic of China. Electronic address:

Objective: Gastrodin, a glucoside of gastrodigenin, inhibits cerebral oxidant stress and apoptosis in multiple central nervous system injury, but its effect in intracerebral hemorrhage (ICH) remains unclear. This study investigated the effect of gastrodin on neuronal apoptosis and neurological deficits in rat ICH model.

Methods: In vitro experiments were performed using hematoma lysate-induced cell damage model in primary cortical neurons. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104483DOI Listing
January 2020

Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke.

J Neuroinflammation 2019 Nov 14;16(1):222. Epub 2019 Nov 14.

Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA.

Background: Stroke remains a leading cause of death and disability worldwide despite recent treatment breakthroughs. A primary event in stroke pathogenesis is the development of a potent and deleterious local and peripheral inflammatory response regulated by the pro-inflammatory cytokine interleukin-1 (IL-1). While the role of IL-1β (main released isoform) has been well studied in stroke, the role of the IL-1α isoform remains largely unknown. Read More

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http://dx.doi.org/10.1186/s12974-019-1599-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857151PMC
November 2019
5.408 Impact Factor

Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study.

Ann Neurol 2020 02 29;87(2):233-245. Epub 2019 Nov 29.

Research Headquarters, Shin Poong Pharmaceutical, Ansan, Korea.

Objective: Otaplimastat is a neuroprotectant that inhibits matrix metalloprotease pathway, and reduces edema and intracerebral hemorrhage induced by recombinant tissue plasminogen activator (rtPA) in animal stroke models. We aimed to assess the safety and efficacy of otaplimastat in patients receiving rtPA.

Methods: This was a phase 2, 2-part, multicenter trial in stroke patients (19-80 years old) receiving rtPA. Read More

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http://dx.doi.org/10.1002/ana.25644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003891PMC
February 2020

Neuroprotection in Rats Following Ischaemia-Reperfusion Injury by GLP-1 Analogues-Liraglutide and Semaglutide.

Cardiovasc Drugs Ther 2019 12;33(6):661-667

The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK.

Purpose: A substantial number of ischaemic stroke patients who receive reperfusion therapy in the acute phase do not ever fully recover. This reveals the urgent need to develop new adjunctive neuroprotective treatment strategies alongside reperfusion therapy. Previous experimental studies demonstrated the potential of glucagon-like peptide-1 (GLP-1) to reduce acute ischaemic damage in the brain. Read More

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http://dx.doi.org/10.1007/s10557-019-06915-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994526PMC
December 2019

Hydrogels for neuroprotection and functional rewiring: a new era for brain engineering.

Neural Regen Res 2020 May;15(5):783-789

Center for Biomedical Technology; Departamento de Tecnología Fotónica y Bioingeniería, ETSI Telecomunicaciones, Universidad Politécnica de Madrid; Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal pathologies. High-performance preclinical results have failed at clinical level, as it has been the case for a wide variety of neuroprotective agents and cell-based therapies employed to treat high prevalent brain pathologies such as stroke, Alzheimer's and Parkinson's diseases. An unquestionable reality is the current absence of effective therapies to neuroprotect the brain, to arrest neurodegeneration and rewire the impaired brain circuits. Read More

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http://dx.doi.org/10.4103/1673-5374.268891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990788PMC

Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review.

Neural Regen Res 2020 May;15(5):773-782

Halal Research Center of IRI, FDA, Tehran; Biotechnology Research Center, Pharmaceutical Technology Institute; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and considering the inclusion and exclusion criteria of the study. Studies were included if focal cerebral ischemia model was performed in mammals and including a control group that has been compared with a minocycline group. Read More

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http://dx.doi.org/10.4103/1673-5374.268898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990777PMC
May 2020
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Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents.

Ann Neurol 2020 01 26;87(1):40-51. Epub 2019 Nov 26.

Department of Neurology, Institute of Translational Neurology, University of Münster, Münster.

Objective: To analyze why numerous acute stroke treatments were successful in the laboratory but failed in large clinical trials.

Methods: We searched all phase 3 trials of medical treatments for acute ischemic stroke and corresponding early clinical and experimental studies. We compared the overall efficacy and assessed the impact of publication bias and study design on the efficacy. Read More

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http://dx.doi.org/10.1002/ana.25643DOI Listing
January 2020

An 81-Year-Old Male with Advanced Dementia and Recurrent Cerebrovascular Events: Is There a Place for Cannabidiol Therapy?

Isr Med Assoc J 2019 Nov;21(11):759-760

Yezreel Valley College, Emek Yezreel, Israel.

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November 2019

Statins for neuroprotection in spontaneous intracerebral hemorrhage.

Neurology 2019 12 11;93(24):1056-1066. Epub 2019 Nov 11.

From the Department of Neurological Surgery (C.-J.C., N.I., T.J.B.), University of Virginia Health System, Charlottesville, VA; Department of Neurological Surgery (D.D., R.F.J.), University of Louisville School of Medicine, Louisville, KY; Clinical Trials Office (L.J.E., A.W.), University of Virginia School of Medicine; Department of Pharmacology (A.P.A.), University of Virginia Health System, Charlottesville, VA; Department of Public Health Sciences (S.J.R., B.B.W., A.M.S.), University of Virginia School of Medicine, Charlottesville, VA; Department of Neurosurgery (N.S.N.), Baptist Health, Jacksonville, FL; and Department of Neurology (B.B.W., K.C.J., A.M.S.), University of Virginia Health System, Charlottesville, VA.

Statins, a common drug class for treatment of dyslipidemia, may be neuroprotective for spontaneous intracerebral hemorrhage (ICH) by targeting secondary brain injury pathways in the surrounding brain parenchyma. Statin-mediated neuroprotection may stem from downregulation of mevalonate and its derivatives, targeting key cell signaling pathways that control proliferation, adhesion, migration, cytokine production, and reactive oxygen species generation. Preclinical studies have consistently demonstrated the neuroprotective and recovery enhancement effects of statins, including improved neurologic function, reduced cerebral edema, increased angiogenesis and neurogenesis, accelerated hematoma clearance, and decreased inflammatory cell infiltration. Read More

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http://dx.doi.org/10.1212/WNL.0000000000008627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937496PMC
December 2019

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis.

Molecules 2019 Nov 7;24(22). Epub 2019 Nov 7.

School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, China.

Diosgenin, a natural product with steroidal structure, has a wide range of clinical applications in China. It also shows great potential in the treatment of blood clots and nerve damage. To enhance the bioavailability as well as efficacy of diosgenin, eighteen diosgenin-amino acid derivatives were designed and synthesized. Read More

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http://dx.doi.org/10.3390/molecules24224025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891328PMC
November 2019

Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat.

PLoS One 2019 7;14(11):e0224870. Epub 2019 Nov 7.

Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia.

Background: Cationic arginine-rich peptides (CARPs) have demonstrated neuroprotective and/or behavioural efficacy in ischemic and hemorrhagic stroke and traumatic brain injury models. Therefore, in this study we investigated the safety and neuroprotective efficacy of the CARPs poly-arginine-18 (R18; 18-mer of arginine) and its D-enantiomer R18D given in the acute bleeding phase in an intracerebral hemorrhage (ICH) model.

Methods: One hundred and fifty-eight male Sprague-Dawley rats received collagenase-induced ICH. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224870PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837498PMC

Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition CREB/PGC-1α Pathway.

Front Pharmacol 2019 22;10:1245. Epub 2019 Oct 22.

Jiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.

Neuroinflammation is one of the important factors aggravating brain injury after ischemic stroke. We aimed to investigate the effects of cerebrolysin (CBL) on neuroinflammation and and the underlying mechanisms. The gene expressions of pro-inflammatory factors and anti-inflammatory factors were analyzed by real time PCR in rat transient middle cerebral artery occlusion (tMCAO) model, lipopolysaccharides-induced neuroinflammatory mice model and LPS-treated mouse primary microglia cells. Read More

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http://dx.doi.org/10.3389/fphar.2019.01245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818051PMC
October 2019
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Edaravone Administration Confers Neuroprotection after Experimental Intracerebral Hemorrhage in Rats via NLRP3 Suppression.

J Stroke Cerebrovasc Dis 2020 Jan 4;29(1):104468. Epub 2019 Nov 4.

Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address:

Objectives: Intracerebral hemorrhage (ICH) is one of the leading causes of disability and mortality in adult, which lacks effective therapies. Edaravone has showed its neuroprotective effects after ischemia stroke, but its effects and possible mechanisms after ICH are poorly understood. Here, we investigated whether edaravone confers neuroprotection after ICH in rats and explored the potential mechanisms involved. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104468DOI Listing
January 2020

[Lysophosphatidic Acid Receptor Signaling Underlying Chronic Pain and Neuroprotective Mechanisms through Prothymosin α].

Authors:
Hiroshi Ueda

Yakugaku Zasshi 2019 ;139(11):1403-1415

Department of Pharmacology and Therapeutic Innovation, Nagasaki University, Institute of Biomedical Sciences.

For my Ph.D. research topic, I isolated endogenous morphine-like analgesic dipeptide, kyotorphin, which mediates Met-enkephalin release, and discovered kyotorphin synthetase, a putative receptor and antagonist. Read More

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http://dx.doi.org/10.1248/yakushi.19-00160DOI Listing
February 2020

EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia.

Int J Mol Sci 2019 Oct 31;20(21). Epub 2019 Oct 31.

Institute of Biochemistry and Molecular Immunology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.

Ischemic stroke is known to cause the accumulation of misfolded proteins and loss of calcium homeostasis leading to impairment of endoplasmic reticulum (ER) function. The unfolded protein response (UPR) is an ER-located and cytoprotective pathway that aims to resolve ER stress. Transmembrane BAX inhibitor-1 motif-containing (TMBIM) protein family member TMBIM3/GRINA is highly expressed in the brain and mostly located at the ER membrane suppressing ER calcium release by inositol-1,4,5-trisphosphate receptors. Read More

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http://dx.doi.org/10.3390/ijms20215421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862264PMC
October 2019
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