7,629 results match your criteria Neuroprotective Agents in Stroke


Clinical Effects of Early Edaravone Use in Acute Ischemic Stroke Patients Treated by Endovascular Reperfusion Therapy.

Stroke 2019 Feb 11:STROKEAHA118023815. Epub 2019 Feb 11.

Department of Acute Critical Care and Disaster Medicine (M.E., Y.O.), Tokyo Medical and Dental University Graduate School of Medicine, Japan.

Background and Purpose- Although several clinical studies suggested the beneficial effects of edaravone in acute ischemic stroke, most were performed under settings that differ from those in the current treatment strategy, which has dramatically changed with progress in reperfusion therapies. This study aimed to evaluate the efficacy of edaravone in patients with acute ischemic stroke treated by emergent endovascular reperfusion therapy. Methods- We conducted a retrospective observational study using a national administrative database. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023815DOI Listing
February 2019
1 Read

Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review.

Diabetes Ther 2019 Feb 6. Epub 2019 Feb 6.

First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.

Diabetes mellitus (DM) is a major risk factor for ischemic stroke. Moreover, patients with DM suffer more severe strokes and have worse functional outcome following an acute stroke than patients without DM. In this context, data from animal studies and emerging evidence from clinical studies suggest that incretin-based antihyperglycemic agents might exert beneficial effects in patients with DM who suffer ischemic stroke. Read More

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http://dx.doi.org/10.1007/s13300-019-0580-zDOI Listing
February 2019

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.

Nat Commun 2019 01 18;10(1):321. Epub 2019 Jan 18.

WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.

Context-dependent inhibition of N-methyl-D-aspartate (NMDA) receptors has important therapeutic implications for the treatment of neurological diseases that are associated with altered neuronal firing and signaling. This is especially true in stroke, where the proton concentration in the afflicted area can increase by an order of magnitude. A class of allosteric inhibitors, the 93-series, shows greater potency against GluN1-GluN2B NMDA receptors in such low pH environments, allowing targeted therapy only within the ischemic region. Read More

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http://dx.doi.org/10.1038/s41467-019-08291-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338780PMC
January 2019
1 Read

Neuroprotective Agents in the Intensive Care Unit: -Neuroprotective Agents in ICU.

J Pharmacopuncture 2018 Dec 31;21(4):226-240. Epub 2018 Dec 31.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Neuroprotection or prevention of neuronal loss is a complicated molecular process that is mediated by various cellular pathways. Use of different pharmacological agents as neuroprotectants has been reported especially in the last decades. These neuroprotective agents act through inhibition of inflammatory processes and apoptosis, attenuation of oxidative stress and reduction of free radicals. Read More

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http://dx.doi.org/10.3831/KPI.2018.21.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333194PMC
December 2018
3 Reads

Protection against stroke with glucagon-like peptide 1 receptor agonists: a systematic review and meta-analysis.

Eur J Neurol 2019 Jan 10. Epub 2019 Jan 10.

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

In experimental stroke models pretreatment with the newly introduced antidiabetic agents, glucagon-like peptide 1 receptor (GLP-1R) agonists, has been shown to exert neuroprotective effects. Published evidence with regard to the effect of treatment with GLP-1R agonists on the risk of stroke was evaluated. Data from prospective randomized placebo-controlled trials up to October 2018 involving GLP-1R agonists which reported cardiovascular outcomes as primary end-points of efficacy and/or safety were meta-analysed. Read More

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http://doi.wiley.com/10.1111/ene.13905
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http://dx.doi.org/10.1111/ene.13905DOI Listing
January 2019
2 Reads

Prolyl hydroxylase domain inhibitors: can multiple mechanisms be an opportunity for ischemic stroke?

Neuropharmacology 2018 Dec 20;148:117-130. Epub 2018 Dec 20.

UCD School of Biomolecular & Biomedical Science, UCD Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

Stroke and cerebrovascular disease are now the fifth most common cause of death behind other diseases such as heart, cancer and respiratory disease and accounts for approximately 40-50 fatalities per 100,000 people each year in the United States. Currently the only therapy for acute stroke, is intravenous administration of tissue plasminogen activator which was approved in 1996 by the FDA. Surprisingly no new treatments have come on the market since, although endovascular mechanical thrombectomy is showing promising results in trials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183067
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http://dx.doi.org/10.1016/j.neuropharm.2018.12.021DOI Listing
December 2018
11 Reads

Marine Compound Xyloketal B as a Potential Drug Development Target for Neuroprotection.

Mar Drugs 2018 Dec 19;16(12). Epub 2018 Dec 19.

Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

Xyloketal B is a natural compound isolated from the mangrove fungus, sp. in the South China Sea. In the past decade, studies have shown that xyloketal B exhibits anti-oxidative, anti-inflammatory, and anti-apoptotic abilities and may serve as a treatment for ischemic stroke. Read More

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http://www.mdpi.com/1660-3397/16/12/516
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http://dx.doi.org/10.3390/md16120516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316771PMC
December 2018
5 Reads

Ceria Nanoparticles Synthesized With Aminocaproic Acid for the Treatment of Subarachnoid Hemorrhage.

Stroke 2018 Dec;49(12):3030-3038

From the Laboratory of Innovative Nanotechnology, Biomedical Research Institute and Department of Neurology, Seoul National University Hospital, Republic of Korea (H.-G.J., D.-W.K., D.Y.K., S.K.K., S.I.K., J.h.H., W.Y., C.K.K., S.-H.L.).

Background and Purpose- Despite early aneurysm repair and aggressive management for complications, subarachnoid hemorrhage (SAH) results in at least 25% mortality rate and 50% persistent neurological deficit. We investigated whether ceria nanoparticles which have potent antioxidative activities can protect against subarachnoid hemorrhage via attenuating fatal brain injuries. Methods- Uniform, 3 nm, water-dispersed ceria nanoparticles were prepared from short sol-gel reaction of cerium (III) ions with aminocaproic acid in aqueous phase. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.022631DOI Listing
December 2018
1 Read

Neuroprotective agents in Acute Ischemic Stroke-A Reality Check.

Biomed Pharmacother 2019 Jan 5;109:2539-2547. Epub 2018 Dec 5.

Department of Clinical Pharmacology, SRM Medical College Hospital & Research Centre, Kattankulathur, Chennai, Tamil Nadu, 603203 India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183639
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http://dx.doi.org/10.1016/j.biopha.2018.11.041DOI Listing
January 2019
9 Reads
2.023 Impact Factor

Synthetic approaches to isocarbacyclin and analogues as potential neuroprotective agents against ischemic stroke.

Bioorg Med Chem 2019 Jan 6;27(2):338-342. Epub 2018 Dec 6.

Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro 27402, USA. Electronic address:

Isocarbacyclin is a valuable synthetic analogue of prostacyclin with potential neuroprotective effects for the treatment of ischemic stroke. Herein, we describe the synthesis of isocarbacyclin and bicyclic analogues in only 7-10 steps, with the ω-side chain diversified at a late stage. A combination of new reaction design, function-oriented synthesis, and late-stage diversification led to a series of compounds that were tested for their neuroprotective activities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183189
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http://dx.doi.org/10.1016/j.bmc.2018.12.010DOI Listing
January 2019
1 Read

Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies.

Cells 2018 Dec 12;7(12). Epub 2018 Dec 12.

Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

Cerebral ischemia-reperfusion is a complicated pathological process. The injury and cascade reactions caused by cerebral ischemia and reperfusion are characterized by high mortality, high recurrence, and high disability. However, only a limited number of antithrombotic drugs, such as recombinant tissue plasminogen activator (r-TPA), aspirin, and heparin, are currently available for ischemic stroke, and its safety concerns is inevitable which associated with reperfusion injury and hemorrhage. Read More

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http://dx.doi.org/10.3390/cells7120270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316103PMC
December 2018
1 Read

Nutrition, Energy Expenditure, Dysphagia, and Self-Efficacy in Stroke Rehabilitation: A Review of the Literature.

Brain Sci 2018 Dec 7;8(12). Epub 2018 Dec 7.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

While significant research has been performed regarding the use of thrombolytic agents and thrombectomy in the setting of acute stroke, other factors, such as nutritional status of stroke patients, is a less explored topic. The topic of nutrition is critical to the discussion of stroke, as up to half of stroke survivors may be considered malnourished at discharge. Dysphagia, old age, restricted upper limb movement, visuospatial impairment, and depression are all important risk factors for malnutrition in this cohort. Read More

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http://dx.doi.org/10.3390/brainsci8120218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316714PMC
December 2018

Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF-κB Pathways.

J Stroke Cerebrovasc Dis 2019 Jan 24;28(1):175-184. Epub 2018 Oct 24.

Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China. Electronic address:

Background: Stevioside, isolated from the herb Stevia rebaudiana, has been widely used as a food sweetener all over the world. Isosteviol Sodium (STV-Na), an injectable formulation of isosteviol sodium salt, has been proved to possess much greater solubility and bioavailability and exhibit protective effects against cerebral ischemia injury in vivo by inhibiting neuron apoptosis. However, the underlying mechanisms of the neuroprotective effects STV-Na are still not completely known. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183052
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.020DOI Listing
January 2019
6 Reads

Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: combined therapies using estrogen.

Curr Neuropharmacol 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires. Argentina.

Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge on underlying mechanisms triggering these insults may help establish neuroprotective treatments. Read More

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http://dx.doi.org/10.2174/1570159X17666181206101314DOI Listing
December 2018
9 Reads

Potential of Exosomes for the Treatment of Stroke.

Cell Transplant 2018 Dec 6:963689718816990. Epub 2018 Dec 6.

1 Department of Anatomy, Histology and Embryology, Discipline of Neuroscience, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood-brain barrier (BBB), and their important role in communication between cells. Read More

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http://dx.doi.org/10.1177/0963689718816990DOI Listing
December 2018
20 Reads

Behavioral tests that reveal long-term deficits after permanent focal cerebral ischemia in mouse.

Behav Brain Res 2019 03 27;360:69-80. Epub 2018 Nov 27.

Equipe de recherche "Pharmacologie de la Circulation Cérébrale" EA 4475, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, 75006 Paris, France. Electronic address:

Efforts are still needed regarding the research of therapeutics for ischemic stroke. While in experimental studies the protective effect of pharmacological agents is often highlighted by a reduction of the lesion size evaluated in the short term (days), in clinical studies a functional recovery of patients suffering from stroke is expected on the long-term (months and years). Long-term functional preclinical studies are highly recommended to evaluate potential neuroprotective agents for stroke, rather than an assessment of the infarction size at a short time point. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.11.040DOI Listing

Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.

Eur J Med Chem 2019 Jan 7;162:132-146. Epub 2018 Nov 7.

Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China. Electronic address:

Stroke is a central nervous system disease that seriously affects people's quality of life and has the second highest rate of morbidity and mortality in the world. At present, clinical treatment strategies for acute ischemic stroke are mainly thrombolytic and thrombectomy therapy. However, these strategies are not able to protect patients from ischemic injuries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183096
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http://dx.doi.org/10.1016/j.ejmech.2018.11.014DOI Listing
January 2019
13 Reads

Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia.

Int J Mol Med 2019 Jan 5;43(1):452-460. Epub 2018 Nov 5.

Department of Internal Neurology, The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan 570311, P.R. China.

The overall incidence rate of stroke is increasing worldwide. Inflammatory damage following a stroke is a leading cause for the poor prognosis and high disability rate observed in stroke patients. Microglia are considered to be the main causative agents of inflammatory injury following cerebral infarction, as they secrete various inflammatory cytokines and cytotoxic factors. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3974
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http://dx.doi.org/10.3892/ijmm.2018.3974DOI Listing
January 2019
10 Reads

Brain Peptides for the Treatment of Neuropsychiatric Disorders.

Curr Pharm Des 2018 ;24(33):3905-3917

Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.

The realization of the importance of growth factors in adult CNS led to several studies investigating their roles in neuropsychiatric disorders. Based on the observations that chronic stress decreases brain-derived neurotrophic factor (BDNF) and antidepressant treatments reverse BDNF to normal levels, "neurotrophic hypothesis of depression" was proposed. Subsequent studies found that several other growth factors, including fibroblast growth factor (FGF), vascular endothelial growth factor, nerve growth factor were also decreased by chronic stress. Read More

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http://dx.doi.org/10.2174/1381612824666181112112309DOI Listing
January 2018
10 Reads

Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke.

Life Sci 2019 Jan 7;216:49-58. Epub 2018 Nov 7.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India. Electronic address:

Aim: Stroke is devastating with a limited choice of intervention. Many pharmacological entities are available but none of them have evolved successfully in counteracting the multifaceted molecular alterations following stroke. Myeloperoxidase (MPO) has been reported to play an important role in neuroinflammation following neurodegenerative diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183072
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http://dx.doi.org/10.1016/j.lfs.2018.11.014DOI Listing
January 2019
10 Reads

Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke.

Br J Pharmacol 2019 Feb 18;176(3):400-415. Epub 2018 Dec 18.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Background And Purpose: Ischaemic stroke is a leading cause of death and long-term disability. Promising neuroprotective compounds are urgently needed to overcome clinical therapeutic limitations. Neuroprotective agents are limited to single-target agents, which further limit their clinical effectiveness. Read More

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http://doi.wiley.com/10.1111/bph.14537
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http://dx.doi.org/10.1111/bph.14537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329622PMC
February 2019
8 Reads

Cerebrolysin for the Treatment of Aneurysmal Subarachnoid Hemorrhage in Adults: A Retrospective Chart Review.

Adv Ther 2018 Dec 9;35(12):2224-2235. Epub 2018 Nov 9.

Department of Neurosurgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Introduction: Cerebrolysin is a neuroprotective drug used in the treatment of acute ischemic stroke. To our knowledge, this drug has never been evaluated in patients with aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to evaluate the effect of Cerebrolysin in patients with aneurysmal SAH. Read More

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http://link.springer.com/10.1007/s12325-018-0832-8
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http://dx.doi.org/10.1007/s12325-018-0832-8DOI Listing
December 2018
12 Reads

The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells.

Biomed Pharmacother 2019 Jan 2;109:181-187. Epub 2018 Nov 2.

Department of Neurology, Xianyang Hospital of Yan'an University, Xianyang, 712000, China.

Endothelial damage and blood brain barrier disruption contribute to ischemic stroke and brain injury. Gliptins are a novel class of treatment agents for diabetes, and recent studies have linked the use of gliptins to neuroprotection. Alogliptin is a type of orally available gliptin that was approved for clinical use by the FDA in 2013. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183390
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http://dx.doi.org/10.1016/j.biopha.2018.10.064DOI Listing
January 2019
14 Reads

An Update on Pediatric Stroke Protocol.

Pediatr Emerg Care 2018 Nov;34(11):810-815

Fellows (McKinney, Magruder) and Professor (Abramo), Pediatric Emergency Medicine, University of Arkansas for Medical, Sciences/Arkansas Children's Hospital.

Pediatric stroke is relatively rare, with approximately 1000 childhood strokes in the United States per year. However, the occurrence of stroke in children leads to significant morbidity and mortality, warranting the development proven screening tools, protocols, and treatment options. Because significant delays in seeking medical attention can occur, time to recognition of pediatric stroke in the emergency department is uniquely challenging and critical. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001653DOI Listing
November 2018
1 Read
0.923 Impact Factor

The protective mechanisms of polydatin in cerebral ischemia.

Eur J Pharmacol 2019 Jan 30;842:133-138. Epub 2018 Oct 30.

School of Pharmacy, Monash University Malaysia, Malaysia.

The prevalence of stroke is high in both developing and developed nations. It causes a heavy social and financial burden to the sufferers and their caregivers. Thrombolytic therapy is the only pharmacological treatment available for stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183062
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http://dx.doi.org/10.1016/j.ejphar.2018.10.039DOI Listing
January 2019
9 Reads

8e Protects against Acute Cerebral Ischemia by Inhibition of PI3Kγ-Mediated Superoxide Generation in Microglia.

Molecules 2018 Oct 31;23(11). Epub 2018 Oct 31.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.

The inflammatory response mediated by microglia plays a critical role in the progression of ischemic stroke. Phosphoinositide 3-kinase gamma (PI3Kγ) has been implicated in multiple inflammatory and autoimmune diseases, making it a promising target for therapeutic intervention. The aim of this study was to evaluate the efficacy of , a hydrogen sulfide (H₂S) releasing derivative of 3--butylphthalide (NBP), on brain damage and PI3Kγ signaling following cerebral ischemia injury. Read More

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http://www.mdpi.com/1420-3049/23/11/2828
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http://dx.doi.org/10.3390/molecules23112828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278485PMC
October 2018
3 Reads

Acteoside Attenuates Oxidative Stress and Neuronal Apoptosis in Rats with Focal Cerebral Ischemia-Reperfusion Injury.

Biol Pharm Bull 2018 ;41(11):1645-1651

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University.

Acteoside (ACT) has been shown to exert antioxidant and neuroprotective effects in neurodegenerative diseases. However, the effect of ACT on cerebral ischemia-reperfusion (I/R) injury is not yet clear. In this study, we found that ACT administration reduced infarct volume and brain edema, and improved neurological deficits, as indicated by the decreased modified neurological severity score. Read More

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https://www.jstage.jst.go.jp/article/bpb/41/11/41_b18-00210/
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http://dx.doi.org/10.1248/bpb.b18-00210DOI Listing
February 2019
3 Reads

The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4.

Cell Mol Life Sci 2019 Feb 30;76(3):523-537. Epub 2018 Oct 30.

Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Ischemic stroke is the most common cerebrovascular disease and considered as a worldwide leading cause of death. After cerebral ischemia, different pathophysiological processes including neuroinflammation, invasion and aggregation of inflammatory cells and up-regulation of cytokines occur simultaneously. In this respect, Toll-like receptors (TLRs) are the first identified important mediators for the activation of the innate immune system and are widely expressed in glial cells and neurons following brain trauma. Read More

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http://link.springer.com/10.1007/s00018-018-2953-2
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http://dx.doi.org/10.1007/s00018-018-2953-2DOI Listing
February 2019
3 Reads

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.

Cochrane Database Syst Rev 2018 10 30;10:CD009622. Epub 2018 Oct 30.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China, 100053.

Background: Gamma aminobutyric acid (GABA) receptor agonists have been shown to have a neuroprotectant effect in reducing infarct size and improving functional outcome in animal models of cerebrovascular disease. However, the sedative effects of GABA receptor agonists have limited their wider application in people with acute stroke, due to the potential risk of stupor. This is an update of a Cochrane Review first published in 2013, and previously updated in 2014 and 2016. Read More

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http://doi.wiley.com/10.1002/14651858.CD009622.pub5
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http://dx.doi.org/10.1002/14651858.CD009622.pub5DOI Listing
October 2018
4 Reads

Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam.

Epilepsia 2018 Dec 25;59(12):2206-2218. Epub 2018 Oct 25.

US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.

Objective: Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neuropathology, and long-term behavioral and cognitive deficits. Rodent models, widely used to evaluate novel medical countermeasures (MCMs) against CWNA exposure, normally express plasma carboxylesterase, an enzyme involved in the metabolism of certain organophosphorus compounds. To better predict the efficacy of novel MCMs against CWNA exposure in human casualties, it is crucial to use appropriate animal models that mirror the human condition. Read More

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http://doi.wiley.com/10.1111/epi.14582
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http://dx.doi.org/10.1111/epi.14582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334636PMC
December 2018
12 Reads

Protective effect of polysaccharide peptide on cerebral ischemia‑reperfusion injury in rats.

Mol Med Rep 2018 Dec 23;18(6):5371-5378. Epub 2018 Oct 23.

Department of Emergency, Shanghai Sixth People's Hospital East Area Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201306, P.R. China.

In the present study, the protective effects and regulatory mechanism of polysaccharide peptide (PSP) were investigated in rats with cerebral ischemia‑reperfusion (IR) injury. Neuroblastoma N2a cells were divided into five groups: Negative control; IR injury; PSP low dose treatment; PSP middle dose treatment; and PSP high dose treatment. In vitro, the cell viability was detected by an MTT assay. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2018.9579
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http://dx.doi.org/10.3892/mmr.2018.9579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236317PMC
December 2018
4 Reads

Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors.

Front Cell Dev Biol 2018 10;6:132. Epub 2018 Oct 10.

Institute for Science and Technology in Medicine, Keele University, Staffordshire, United Kingdom.

Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures optimum ATP production and cell integrity, and is associated both directly and indirectly with reactive oxygen species (ROS) formation. HIF activation can either reduce ROS formation by suppressing the function of mitochondrial tricarboxylic acid cycle (TCA cycle), or increase ROS formation via NADPH oxidase (NOX), a target gene of HIF pathway. Read More

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https://www.frontiersin.org/article/10.3389/fcell.2018.00132
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http://dx.doi.org/10.3389/fcell.2018.00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192379PMC
October 2018
4 Reads

Buyang Huanwu Decoction Attenuates Infiltration of Natural Killer Cells and Protects Against Ischemic Brain Injury.

Cell Physiol Biochem 2018 24;50(4):1286-1300. Epub 2018 Oct 24.

School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai,

Background/aims: Natural killer (NK) cells are among the first immune cells that respond to an ischemic insult in human brains. The infiltrated NK cells damage blood-brain barrier (BBB) and exacerbate brain infarction. Buyang Huanwu Decoction (BHD), a classic Chinese traditional herbal prescription, has long been used for the treatment of ischemic stroke. Read More

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https://www.karger.com/Article/FullText/494587
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http://dx.doi.org/10.1159/000494587DOI Listing
November 2018
13 Reads

Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects.

Int J Mol Sci 2018 Oct 19;19(10). Epub 2018 Oct 19.

Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei 11031, Taiwan.

Due to its high oxygen demand and abundance of peroxidation-susceptible lipid cells, the brain is particularly vulnerable to oxidative stress. Induced by a redox state imbalance involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system, oxidative stress plays a central role in a common pathophysiology that underpins neuronal cell death in acute neurological disorders epitomized by stroke and chronic ones such as Alzheimer's disease. After cerebral ischemia, for example, inflammation bears a key responsibility in the development of permanent neurological damage. Read More

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http://www.mdpi.com/1422-0067/19/10/3252
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http://dx.doi.org/10.3390/ijms19103252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213994PMC
October 2018
8 Reads

Resveratrol Preconditioning Induces Genomic and Metabolic Adaptations within the Long-Term Window of Cerebral Ischemic Tolerance Leading to Bioenergetic Efficiency.

Mol Neurobiol 2018 Oct 20. Epub 2018 Oct 20.

Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.

Neuroprotective agents administered post-cerebral ischemia have failed so far in the clinic to promote significant recovery. Thus, numerous efforts were redirected toward prophylactic approaches such as preconditioning as an alternative therapeutic strategy. Our laboratory has revealed a novel long-term window of cerebral ischemic tolerance mediated by resveratrol preconditioning (RPC) that lasts for 2 weeks in mice. Read More

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http://link.springer.com/10.1007/s12035-018-1380-6
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http://dx.doi.org/10.1007/s12035-018-1380-6DOI Listing
October 2018
10 Reads

Association of platelet response to cilostazol with clinical outcome and CYP genotype in patients with cerebral infarction.

Thromb Res 2018 12 10;172:14-20. Epub 2018 Oct 10.

Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Japan; Department of Blood Transfusion and Cell Therapy, Ehime University Graduate School of Medicine, Japan. Electronic address:

Introduction: Cilostazol, an anti-platelet drug that inhibits phosphodiesterase 3, is beneficial for patients with atherothrombosis. In contrast to other anti-platelet drugs such as aspirin and thienopyridines, little information is available on the relationship between platelet responses to cilostazol and clinical outcomes.

Materials And Methods: We conducted a prospective study on patients with cerebral infarction who were treated with cilostazol. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848183055
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http://dx.doi.org/10.1016/j.thromres.2018.10.003DOI Listing
December 2018
4 Reads

Calpeptin Reduces Neurobehavioral Deficits and Neuronal Apoptosis Following Subarachnoid Hemorrhage in Rats.

J Stroke Cerebrovasc Dis 2019 Jan 16;28(1):125-132. Epub 2018 Oct 16.

Department of Neurosurgery, Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science, Xiangyang, Hubei, China. Electronic address:

Background: Inhibition of calpain activity provides neuroprotection in multiple central nervous system injury, but the role and mechanism of calpain in subarachnoid hemorrhage (SAH) remain unclear. This study was undertaken to determine the effects of inhibition of calpain on neurological deficit and neuronal apoptosis following experimental SAH.

Methods: The endovascular perforation model of SAH was produced in male Sprague-Dawley rats. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.026DOI Listing
January 2019

The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3β inhibition in intracerebral hemorrhage rats.

Eur J Pharmacol 2018 Dec 15;840:50-59. Epub 2018 Oct 15.

Department of Biopharmaceutical Sciences (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University, Heilongjiang, China. Electronic address:

To the clinical cognitive impairment following intracerebral hemorrhage, comprehensive neuropsychological assessments and efficacious interventions have rarely been conducted. Lithium chloride, a classical treatment for bipolar disorder, has shown neuroprotective effects through glycogen synthase kinase-3β inhibition in a variety of central nervous system diseases, including stroke. Since neurons that contain glutamate play crucial roles in psychological functions, such as learning and memory, the glutamate-mediated excitotoxicity and consequent neuronal death and cognitive impairment in hippocampus may co-determine the clinical course of intracerebral hemorrhage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183059
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http://dx.doi.org/10.1016/j.ejphar.2018.10.019DOI Listing
December 2018
15 Reads

Reperfusion Changes After Stroke and Practical Approaches for Neuroprotection.

Neuroimaging Clin N Am 2018 Nov;28(4):663-682

Center for Unruptured Brain Aneurysms, Neurological Surgery PC, 1991 Marcus Avenue, Suite 108, Lake Success, NY 11042, USA; Hybernia Medical LLC, 626 RexCorp Plaza, Uniondale, NY 11556, USA.

Reperfusion is the first line of care in a growing number of eligible acute ischemic stroke patients. Early reperfusion with thrombolytic drugs and endovascular mechanical devices is associated with improved outcome and lower mortality rates compared with natural history. Reperfusion is not without risk, however, and may result in reperfusion injury, which manifests in hemorrhagic transformation, brain edema, infarct progression, and neurologic worsening. Read More

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http://dx.doi.org/10.1016/j.nic.2018.06.008DOI Listing
November 2018

Potential application value of xenon in stroke treatment.

Med Gas Res 2018 Jul-Sep;8(3):116-120. Epub 2018 Sep 25.

Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Stroke is an acute disease with extremely high mortality and disability, including ischemic stroke and hemorrhagic stroke. Currently only limited drugs and treatments have been shown to have neuroprotective effects in stroke. As a medical gas, xenon has been proven to have neuroprotective effect in considerable amount of previous study. Read More

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http://dx.doi.org/10.4103/2045-9912.241077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178644PMC
September 2018
4 Reads

MMP-9 Upregulation is Attenuated by the Monoclonal TLR2 Antagonist T2.5 After Oxygen-Glucose Deprivation and Reoxygenation in Rat Brain Microvascular Endothelial Cells.

J Stroke Cerebrovasc Dis 2019 Jan 8;28(1):97-106. Epub 2018 Oct 8.

Department of Neurology, The First People's Hospital of Yunnan Province, Kunming, China. Electronic address:

Background: Blood-brain barrier (BBB) disruption plays a key role in the pathophysiology of acute ischemic stroke. Matrix metalloproteinases-2/9 (MMP-2/9) have been shown to participate in the disruption of the BBB and hemorrhagic transformation after cerebral ischemia. Toll-like receptor 2 (TLR2) may also be correlated with endothelial cell injury during ischemia-reperfusion events. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.014DOI Listing
January 2019
1 Read

(-)-α-bisabolol prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice.

Eur J Pharmacol 2019 Jan 1;842:270-280. Epub 2018 Oct 1.

Post-Graduate Programme in Pharmacology, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil; Post-Graduate Programme in Medical Sciences, Department of Medicine, Federal University of Ceará, Fortaleza, Brazil; Institute of Biomedicine of Brazilian Semi-arid, Fortaleza, Brazil. Electronic address:

The pathophysiology of ischemic stroke involves multiple events such as inflammation and oxidative stress which will lead to neuronal death and cognitive deficits. The (-)-α-bisabolol is a monocyclic sesquiterpene alcohol found in various plants and mainly in Matricaria chamomilla, which exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. The aim of this work was to investigate the neuroprotective effects of (-)-α-bisabolol in mice underwent permanent occlusion of the middle cerebral artery (pMCAO). Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.09.036DOI Listing
January 2019

Recurrent cerebral microbleeds with acute stroke symptoms: A case report.

Medicine (Baltimore) 2018 Sep;97(39):e12480

Department of Neurology, Chonbuk National University School of Medicine and Hospital, Jeonju, South Korea.

Rationale: Cerebral microbleeds are lesions that appear as round low signal intensity areas with a diameter of 2-5 mm on gradient echo T2-weighted sequence magnetic resonance imaging. Cerebral microblees are hemorrhages found in the brain parenchyma and they are caused by the extravasation of the blood. Although more patients with ischemic stroke are found to have cerebral microbleeds, only a few studies have evaluated other neurologic abnormalities outside of cognitive dysfunction due to cerebral microbleeds. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809280-0005
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http://dx.doi.org/10.1097/MD.0000000000012480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181546PMC
September 2018
7 Reads

B355252, A Novel Small Molecule, Confers Neuroprotection Against Cobalt Chloride Toxicity In Mouse Hippocampal Cells Through Altering Mitochondrial Dynamics And Limiting Autophagy Induction.

Int J Med Sci 2018 7;15(12):1384-1396. Epub 2018 Sep 7.

Department of Pharmaceutical Sciences, Biomanufacturing Research Institute Biotechnology Enterprise (BRITE), North Carolina Central University, Durham, NC USA.

Cerebral hypoxia as often occurs in cases of stroke, hemorrhage, or other traumatic brain injuries, is one of the leading causes of death worldwide and a main driver of disabilities in the elderly. Using a chemical mimetic of hypoxia, cobalt chloride (CoCl), we tested the ability of a novel small molecule, 4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide (B355252), to alleviate CoCl-induced damage in mouse hippocampal HT22 cells. A dose-dependent decrease in cell viability was observed during CoCl treatment along with increases in mitochondrial membrane potential and generation of reactive oxygen species (ROS). Read More

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http://www.medsci.org/v15p1384.htm
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http://dx.doi.org/10.7150/ijms.24702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158673PMC
January 2019
3 Reads

Thrombopoietin could protect cerebral tissue against ischemia-reperfusion injury by suppressing NF-κB and MMP-9 expression in rats.

Int J Med Sci 2018 10;15(12):1341-1348. Epub 2018 Aug 10.

Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

To determine the neuroprotective effects and underpinning mechanisms of thrombopoietin (TPO), Matrix Metalloproteinase-9(MMP-9) and Nuclear Factor-κB (NF-κB) after focal cerebral ischemia-reperfusion in rats. Male rats underwent 2 hours of right middle cerebral artery occlusion (MCAO) followed by 22 hours of reperfusion. PBS or TPO (0. Read More

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http://www.medsci.org/v15p1341.htm
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http://dx.doi.org/10.7150/ijms.27543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158660PMC
January 2019
4 Reads

Berberine attenuates ischemia-reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation.

Acta Pharmacol Sin 2018 Nov;39(11):1706-1715

Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.

Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke. Berberine is a natural medicine with multiple beneficial biological activities. In this study, we explored the mechanisms underlying the neuroprotective action of berberine in mice subjected transient middle cerebral artery occlusion (tMCAO). Read More

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http://dx.doi.org/10.1038/s41401-018-0160-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289370PMC
November 2018
15 Reads

Imidazoline Receptor Agonists for Managing Hypertension May Hold Promise for Treatment of Intracerebral Hemorrhage.

Curr Mol Med 2018 ;18(4):241-251

Department of Neurology, University of Minnesota, Minneapolis, MN, United States.

Intracerebral hemorrhage (ICH), which accounts for 10% of all strokes, leads to higher morbidity and mortality compared with other stroke subtypes. Hypertension has been recognized as a major risk factor for ICH. Current antihypertensive options have not been fully effective for either prevention of ICH or ameliorating its complications. Read More

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http://dx.doi.org/10.2174/1566524018666180926163712DOI Listing
January 2018
6 Reads

IMM-H004, a Novel Coumarin Derivative Compound, Inhibits HO-Induced Neurotoxicity via Antioxidant and Antiapoptosis in PC12 Cells.

J Stroke Cerebrovasc Dis 2018 Dec 19;27(12):3396-3403. Epub 2018 Sep 19.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China. Electronic address:

IMM-H004 [7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-coumarin] is a novel derivative of coumarin, which played neuroprotective roles in brain ischemia in rats in previous studies. Although antiapoptosis and improving synapsis structure were proved, the effects and mechanisms of IMM-H004 in brain ischemia need further study. In this paper, the effect of IMM-H004 on HO-induced neurotoxicity in pheochromocytoma (PC12) cells was researched. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183026
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.05.022DOI Listing
December 2018
16 Reads

Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke.

Elife 2018 09 21;7. Epub 2018 Sep 21.

Department of Pharmacology, Center for Cardiovascular Research, University of Nevada, Reno, United States.

Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transient receptor potential ankyrin 1 (TRPA1) channel in cerebral artery endothelial cells, leading to vasodilation. We hypothesized that TRPA1 channels in endothelial cells are activated by hypoxia-derived reactive oxygen species, leading to cerebral artery dilation and reduced ischemic damage. Using isolated cerebral arteries expressing a Ca biosensor in endothelial cells, we show that 4-hydroxynonenal and hypoxia increased TRPA1 activity, detected as TRPA1 sparklets. Read More

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https://elifesciences.org/articles/35316
Publisher Site
http://dx.doi.org/10.7554/eLife.35316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177258PMC
September 2018
6 Reads

inhibition enhances progesterone-induced functional recovery in a mouse model of ischemia.

Proc Natl Acad Sci U S A 2018 10 20;115(41):E9668-E9677. Epub 2018 Sep 20.

Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107;

Progesterone (P4) is a potent neuroprotectant and a promising therapeutic for stroke treatment. However, the underlying mechanism(s) remain unclear. Our laboratory recently reported that brain-derived neurotrophic factor (BDNF) is a critical mediator of P4's protective actions and that P4-induced BDNF release from cortical astrocytes is mediated by a membrane-associated progesterone receptor, Pgrmc1. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1803384115
Publisher Site
http://dx.doi.org/10.1073/pnas.1803384115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187141PMC
October 2018
4 Reads