7,557 results match your criteria Neuroprotective Agents in Stroke


Neuroprotective agents in Acute Ischemic Stroke-A Reality Check.

Biomed Pharmacother 2019 Jan 5;109:2539-2547. Epub 2018 Dec 5.

Department of Clinical Pharmacology, SRM Medical College Hospital & Research Centre, Kattankulathur, Chennai, Tamil Nadu, 603203 India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183639
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http://dx.doi.org/10.1016/j.biopha.2018.11.041DOI Listing
January 2019
1 Read

Synthetic approaches to isocarbacyclin and analogues as potential neuroprotective agents against ischemic stroke.

Bioorg Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro 27402, USA. Electronic address:

Isocarbacyclin is a valuable synthetic analogue of prostacyclin with potential neuroprotective effects for the treatment of ischemic stroke. Herein, we describe the synthesis of isocarbacyclin and bicyclic analogues in only 7-10 steps, with the ω-side chain diversified at a late stage. A combination of new reaction design, function-oriented synthesis, and late-stage diversification led to a series of compounds that were tested for their neuroprotective activities. Read More

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http://dx.doi.org/10.1016/j.bmc.2018.12.010DOI Listing
December 2018

Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies.

Cells 2018 Dec 12;7(12). Epub 2018 Dec 12.

Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

Cerebral ischemia-reperfusion is a complicated pathological process. The injury and cascade reactions caused by cerebral ischemia and reperfusion are characterized by high mortality, high recurrence, and high disability. However, only a limited number of antithrombotic drugs, such as recombinant tissue plasminogen activator (r-TPA), aspirin, and heparin, are currently available for ischemic stroke, and its safety concerns is inevitable which associated with reperfusion injury and hemorrhage. Read More

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http://dx.doi.org/10.3390/cells7120270DOI Listing
December 2018

Nutrition, Energy Expenditure, Dysphagia, and Self-Efficacy in Stroke Rehabilitation: A Review of the Literature.

Brain Sci 2018 Dec 7;8(12). Epub 2018 Dec 7.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

While significant research has been performed regarding the use of thrombolytic agents and thrombectomy in the setting of acute stroke, other factors, such as nutritional status of stroke patients, is a less explored topic. The topic of nutrition is critical to the discussion of stroke, as up to half of stroke survivors may be considered malnourished at discharge. Dysphagia, old age, restricted upper limb movement, visuospatial impairment, and depression are all important risk factors for malnutrition in this cohort. Read More

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http://dx.doi.org/10.3390/brainsci8120218DOI Listing
December 2018

Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: combined therapies using estrogen.

Curr Neuropharmacol 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires. Argentina.

Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge on underlying mechanisms triggering these insults may help establish neuroprotective treatments. Read More

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http://dx.doi.org/10.2174/1570159X17666181206101314DOI Listing
December 2018
3 Reads

Potential of Exosomes for the Treatment of Stroke.

Cell Transplant 2018 Dec 6:963689718816990. Epub 2018 Dec 6.

1 Department of Anatomy, Histology and Embryology, Discipline of Neuroscience, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood-brain barrier (BBB), and their important role in communication between cells. Read More

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http://dx.doi.org/10.1177/0963689718816990DOI Listing
December 2018
3 Reads

Behavioral tests that reveal long-term deficits after permanent focal cerebral ischemia in mouse.

Behav Brain Res 2018 Nov 27;360:69-80. Epub 2018 Nov 27.

Equipe de recherche "Pharmacologie de la Circulation Cérébrale" EA 4475, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie de Paris, 75006 Paris, France. Electronic address:

Efforts are still needed regarding the research of therapeutics for ischemic stroke. While in experimental studies the protective effect of pharmacological agents is often highlighted by a reduction of the lesion size evaluated in the short term (days), in clinical studies a functional recovery of patients suffering from stroke is expected on the long-term (months and years). Long-term functional preclinical studies are highly recommended to evaluate potential neuroprotective agents for stroke, rather than an assessment of the infarction size at a short time point. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.11.040DOI Listing
November 2018

Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.

Eur J Med Chem 2018 Nov 7;162:132-146. Epub 2018 Nov 7.

Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China. Electronic address:

Stroke is a central nervous system disease that seriously affects people's quality of life and has the second highest rate of morbidity and mortality in the world. At present, clinical treatment strategies for acute ischemic stroke are mainly thrombolytic and thrombectomy therapy. However, these strategies are not able to protect patients from ischemic injuries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183096
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http://dx.doi.org/10.1016/j.ejmech.2018.11.014DOI Listing
November 2018
7 Reads

Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia.

Int J Mol Med 2019 Jan 5;43(1):452-460. Epub 2018 Nov 5.

Department of Internal Neurology, The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan 570311, P.R. China.

The overall incidence rate of stroke is increasing worldwide. Inflammatory damage following a stroke is a leading cause for the poor prognosis and high disability rate observed in stroke patients. Microglia are considered to be the main causative agents of inflammatory injury following cerebral infarction, as they secrete various inflammatory cytokines and cytotoxic factors. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3974
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http://dx.doi.org/10.3892/ijmm.2018.3974DOI Listing
January 2019
4 Reads

Brain Peptides for the Treatment of Neuropsychiatric Disorders.

Curr Pharm Des 2018 Nov 11. Epub 2018 Nov 11.

Institute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara. Turkey.

The realization of the importance of growth factors in adult CNS led to several studies investigating their roles in neuropsychiatric disorders. Based on the observations that chronic stress decreases brain-derived neurotrophic factor (BDNF) and antidepressant treatments reverse BDNF to normal levels, "neurotrophic hypothesis of depression" was proposed. Subsequent studies found that several other growth factors, including fibroblast growth factor (FGF), vascular endothelial growth factor, nerve growth factor were also decreased by chronic stress. Read More

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http://dx.doi.org/10.2174/1381612824666181112112309DOI Listing
November 2018
3 Reads

Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke.

Br J Pharmacol 2018 Nov 10. Epub 2018 Nov 10.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Background And Purpose: Ischemic stroke is a leading cause of death and long-term disability. Promising neuroprotective compounds are urgently needed to overcome the clinical therapeutic limitations. Neuroprotective agents are limited to single-target agents, which further limited their clinical effectiveness. Read More

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http://doi.wiley.com/10.1111/bph.14537
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http://dx.doi.org/10.1111/bph.14537DOI Listing
November 2018
3 Reads

Cerebrolysin for the Treatment of Aneurysmal Subarachnoid Hemorrhage in Adults: A Retrospective Chart Review.

Adv Ther 2018 Dec 9;35(12):2224-2235. Epub 2018 Nov 9.

Department of Neurosurgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Introduction: Cerebrolysin is a neuroprotective drug used in the treatment of acute ischemic stroke. To our knowledge, this drug has never been evaluated in patients with aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to evaluate the effect of Cerebrolysin in patients with aneurysmal SAH. Read More

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http://link.springer.com/10.1007/s12325-018-0832-8
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http://dx.doi.org/10.1007/s12325-018-0832-8DOI Listing
December 2018
8 Reads

The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells.

Biomed Pharmacother 2019 Jan 2;109:181-187. Epub 2018 Nov 2.

Department of Neurology, Xianyang Hospital of Yan'an University, Xianyang, 712000, China.

Endothelial damage and blood brain barrier disruption contribute to ischemic stroke and brain injury. Gliptins are a novel class of treatment agents for diabetes, and recent studies have linked the use of gliptins to neuroprotection. Alogliptin is a type of orally available gliptin that was approved for clinical use by the FDA in 2013. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183390
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http://dx.doi.org/10.1016/j.biopha.2018.10.064DOI Listing
January 2019
8 Reads

An Update on Pediatric Stroke Protocol.

Pediatr Emerg Care 2018 Nov;34(11):810-815

Fellows (McKinney, Magruder) and Professor (Abramo), Pediatric Emergency Medicine, University of Arkansas for Medical, Sciences/Arkansas Children's Hospital.

Pediatric stroke is relatively rare, with approximately 1000 childhood strokes in the United States per year. However, the occurrence of stroke in children leads to significant morbidity and mortality, warranting the development proven screening tools, protocols, and treatment options. Because significant delays in seeking medical attention can occur, time to recognition of pediatric stroke in the emergency department is uniquely challenging and critical. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001653DOI Listing
November 2018
1 Read

The protective mechanisms of polydatin in cerebral ischemia.

Eur J Pharmacol 2019 Jan 30;842:133-138. Epub 2018 Oct 30.

School of Pharmacy, Monash University Malaysia, Malaysia.

The prevalence of stroke is high in both developing and developed nations. It causes a heavy social and financial burden to the sufferers and their caregivers. Thrombolytic therapy is the only pharmacological treatment available for stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183062
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http://dx.doi.org/10.1016/j.ejphar.2018.10.039DOI Listing
January 2019
4 Reads

Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam.

Epilepsia 2018 Dec 25;59(12):2206-2218. Epub 2018 Oct 25.

US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.

Objective: Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neuropathology, and long-term behavioral and cognitive deficits. Rodent models, widely used to evaluate novel medical countermeasures (MCMs) against CWNA exposure, normally express plasma carboxylesterase, an enzyme involved in the metabolism of certain organophosphorus compounds. To better predict the efficacy of novel MCMs against CWNA exposure in human casualties, it is crucial to use appropriate animal models that mirror the human condition. Read More

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http://doi.wiley.com/10.1111/epi.14582
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http://dx.doi.org/10.1111/epi.14582DOI Listing
December 2018
3 Reads

Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors.

Front Cell Dev Biol 2018 10;6:132. Epub 2018 Oct 10.

Institute for Science and Technology in Medicine, Keele University, Staffordshire, United Kingdom.

Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures optimum ATP production and cell integrity, and is associated both directly and indirectly with reactive oxygen species (ROS) formation. HIF activation can either reduce ROS formation by suppressing the function of mitochondrial tricarboxylic acid cycle (TCA cycle), or increase ROS formation via NADPH oxidase (NOX), a target gene of HIF pathway. Read More

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https://www.frontiersin.org/article/10.3389/fcell.2018.00132
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http://dx.doi.org/10.3389/fcell.2018.00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192379PMC
October 2018
3 Reads

Buyang Huanwu Decoction Attenuates Infiltration of Natural Killer Cells and Protects Against Ischemic Brain Injury.

Cell Physiol Biochem 2018 24;50(4):1286-1300. Epub 2018 Oct 24.

School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai,

Background/aims: Natural killer (NK) cells are among the first immune cells that respond to an ischemic insult in human brains. The infiltrated NK cells damage blood-brain barrier (BBB) and exacerbate brain infarction. Buyang Huanwu Decoction (BHD), a classic Chinese traditional herbal prescription, has long been used for the treatment of ischemic stroke. Read More

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https://www.karger.com/Article/FullText/494587
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http://dx.doi.org/10.1159/000494587DOI Listing
November 2018
6 Reads

Resveratrol Preconditioning Induces Genomic and Metabolic Adaptations within the Long-Term Window of Cerebral Ischemic Tolerance Leading to Bioenergetic Efficiency.

Mol Neurobiol 2018 Oct 20. Epub 2018 Oct 20.

Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.

Neuroprotective agents administered post-cerebral ischemia have failed so far in the clinic to promote significant recovery. Thus, numerous efforts were redirected toward prophylactic approaches such as preconditioning as an alternative therapeutic strategy. Our laboratory has revealed a novel long-term window of cerebral ischemic tolerance mediated by resveratrol preconditioning (RPC) that lasts for 2 weeks in mice. Read More

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http://link.springer.com/10.1007/s12035-018-1380-6
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http://dx.doi.org/10.1007/s12035-018-1380-6DOI Listing
October 2018
5 Reads

Potential application value of xenon in stroke treatment.

Med Gas Res 2018 Jul-Sep;8(3):116-120. Epub 2018 Sep 25.

Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Stroke is an acute disease with extremely high mortality and disability, including ischemic stroke and hemorrhagic stroke. Currently only limited drugs and treatments have been shown to have neuroprotective effects in stroke. As a medical gas, xenon has been proven to have neuroprotective effect in considerable amount of previous study. Read More

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http://dx.doi.org/10.4103/2045-9912.241077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178644PMC
September 2018
3 Reads

Recurrent cerebral microbleeds with acute stroke symptoms: A case report.

Medicine (Baltimore) 2018 Sep;97(39):e12480

Department of Neurology, Chonbuk National University School of Medicine and Hospital, Jeonju, South Korea.

Rationale: Cerebral microbleeds are lesions that appear as round low signal intensity areas with a diameter of 2-5 mm on gradient echo T2-weighted sequence magnetic resonance imaging. Cerebral microblees are hemorrhages found in the brain parenchyma and they are caused by the extravasation of the blood. Although more patients with ischemic stroke are found to have cerebral microbleeds, only a few studies have evaluated other neurologic abnormalities outside of cognitive dysfunction due to cerebral microbleeds. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809280-0005
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http://dx.doi.org/10.1097/MD.0000000000012480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181546PMC
September 2018
2 Reads

Imidazoline Receptor Agonists for Managing Hypertension May Hold Promise for Treatment of Intracerebral Hemorrhage.

Curr Mol Med 2018 ;18(4):241-251

Department of Neurology, University of Minnesota, Minneapolis, MN, United States.

Intracerebral hemorrhage (ICH), which accounts for 10% of all strokes, leads to higher morbidity and mortality compared with other stroke subtypes. Hypertension has been recognized as a major risk factor for ICH. Current antihypertensive options have not been fully effective for either prevention of ICH or ameliorating its complications. Read More

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http://dx.doi.org/10.2174/1566524018666180926163712DOI Listing
January 2018
4 Reads

inhibition enhances progesterone-induced functional recovery in a mouse model of ischemia.

Proc Natl Acad Sci U S A 2018 10 20;115(41):E9668-E9677. Epub 2018 Sep 20.

Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107;

Progesterone (P4) is a potent neuroprotectant and a promising therapeutic for stroke treatment. However, the underlying mechanism(s) remain unclear. Our laboratory recently reported that brain-derived neurotrophic factor (BDNF) is a critical mediator of P4's protective actions and that P4-induced BDNF release from cortical astrocytes is mediated by a membrane-associated progesterone receptor, Pgrmc1. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1803384115
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http://dx.doi.org/10.1073/pnas.1803384115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187141PMC
October 2018
3 Reads

Protective Effects of Oleuropein Against Cerebral Ischemia/Reperfusion by Inhibiting Neuronal Apoptosis.

Med Sci Monit 2018 Sep 19;24:6587-6598. Epub 2018 Sep 19.

Department of Nursing, Tangshan Gongren Hospital, Tangshan, Hebei, China (mainland).

BACKGROUND In this study, we investigated the potential neuroprotective effect of oleuropein (OLE) on apoptotic changes via modulating Akt/glycogen synthase kinase 3 beta (Akt/GSK-3b) signaling in a rat model of cerebral ischemia/reperfusion injury (IRI). MATERIAL AND METHODS Sprague-Dawley male rats (12 weeks, n=200) were randomly assigned to 5 groups: sham group, vehicle (IRI+ vehicle) group, OLE (IRI+OLE) group, OLE+LY294002 (IRI+OLE+LY294002) group, and LY294002(IRI+LY294002) group. The rats were subjected to cerebral ischemia/reperfusion injury (IRI) model and treated once daily for 5 days with vehicle and OLE (100 mg/kg via intraperitoneal injection) after IRI injury. Read More

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http://dx.doi.org/10.12659/MSM.912336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158998PMC
September 2018
1 Read

Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice.

Transl Stroke Res 2018 12 17;9(6):654-668. Epub 2018 Sep 17.

Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University, No 25 Taiping Street, Jiangyang District, Luzhou, 646000, Sichuan Province, China.

Subarachnoid hemorrhage (SAH) is a neurologically destructive stroke in which early brain injury (EBI) plays a pivotal role in poor patient outcomes. Expanding upon our previous work, multiple techniques and methods were used in this preclinical study to further elucidate the mechanisms underlying the beneficial effects of apolipoprotein E (ApoE) against EBI after SAH in murine apolipoprotein E gene-knockout mice (Apoe, KO) and wild-type mice (WT) on a C57BL/6J background. We reported that Apoe deficiency resulted in a more extensive EBI at 48 h after SAH in mice demonstrated by MRI scanning and immunohistochemical staining and exhibited more extensive white matter injury and neuronal apoptosis than WT mice. Read More

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http://link.springer.com/10.1007/s12975-018-0665-4
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http://dx.doi.org/10.1007/s12975-018-0665-4DOI Listing
December 2018
8 Reads
1.940 Impact Factor

Cilostazol for treatment of cerebral infarction.

Expert Opin Pharmacother 2018 Oct 13;19(15):1719-1726. Epub 2018 Sep 13.

a Department of Cardiovascular Regeneration and Medicine , Research Center for Radiation Genome Medicine, Research Institute for Radiation Biology and Medicine (RIRBM), Hiroshima University , Hiroshima , Japan.

Introduction: Stroke not only causes critical disability and death but is also a cause of anxiety with the possibility of secondary cardiovascular events including secondary ischemic stroke. Indeed, patients with a history of previous stroke have a high rate of stroke recurrence, indicating the clinical importance of secondary stroke prevention. Area of covered: This review provides an overview of the pooled evidence for cilostazol's use in the management of secondary stroke prevention. Read More

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http://dx.doi.org/10.1080/14656566.2018.1515199DOI Listing
October 2018

Post-stroke DHA Treatment Protects Against Acute Ischemic Brain Injury by Skewing Macrophage Polarity Toward the M2 Phenotype.

Transl Stroke Res 2018 12 10;9(6):669-680. Epub 2018 Sep 10.

Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, People's Republic of China.

Systemic docosahexaenoic acid (DHA) has been explored as a clinically feasible protectant in stroke models. However, the mechanism for DHA-afforded neuroprotection remains elusive. Transient middle cerebral artery occlusion (tMCAO) was induced for 1 h. Read More

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http://dx.doi.org/10.1007/s12975-018-0662-7DOI Listing
December 2018

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury.

Proc Natl Acad Sci U S A 2018 09 10;115(39):E9230-E9238. Epub 2018 Sep 10.

Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA 15213;

Recombinant tissue plasminogen activator (tPA) is a Food and Drug Administration-approved thrombolytic treatment for ischemic stroke. tPA is also naturally expressed in glial and neuronal cells of the brain, where it promotes axon outgrowth and synaptic plasticity. However, there are conflicting reports of harmful versus neuroprotective effects of tPA in acute brain injury models. Read More

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http://dx.doi.org/10.1073/pnas.1810693115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166834PMC
September 2018
1 Read

Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion.

J Pharmacol Sci 2018 Sep 25;138(1):16-22. Epub 2018 Aug 25.

Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, 100053, China; Beijing Institute for Brain Disorders, Beijing, 100053, China. Electronic address:

Nitrosative/oxidative stress plays an important role in neuronal death following cerebral ischemia/reperfusion (I/R). Chrysophanol (CHR) has been shown to afford significant neuroprotection on ischemic stroke, however, whether its mechanism is related to attenuating nitrosative/oxidative stress is not clear. In the present study, we investigated the effect of CHR on neuronal injury related to nitric oxide (NO) production by using mouse middle cerebral artery occlusion (MCAO) model. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.002DOI Listing
September 2018
7 Reads

Memory deficits and hippocampal inflammation in cerebral hypoperfusion and reperfusion in male rats: Neuroprotective role of vanillic acid.

Life Sci 2018 Oct 6;211:126-132. Epub 2018 Sep 6.

Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Ischemic stroke is one of the leading causes of neurological deterioration and mortality worldwide. Neuroprotective strategies are being investigated to minimize cognitive deficits after ischemic events. Here we investigated the neuroprotective potential of vanillic acid (VA) in an animal model of transient bilateral common carotid artery occlusion and reperfusion (BCCAO/R). Read More

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http://dx.doi.org/10.1016/j.lfs.2018.08.065DOI Listing
October 2018
1 Read

Design of lactoferrin modified lipid nano-carriers for efficient brain-targeted delivery of nimodipine.

Mater Sci Eng C Mater Biol Appl 2018 Nov 6;92:1031-1040. Epub 2018 Feb 6.

College Pharmacy, Jiamusi University, 148 Xuefu Street, Jiamusi, Heilongjiang 154007, China. Electronic address:

Blood-brain barrier (BBB) was the major obstacle for efficient delivery of therapeutic agents to brain tissue. To overcome this barrier, a novel lactoferrin modified long circulation nanostructured lipid carriers (Lf-NLC) was designed and synthesized for the efficient delivery of neuroprotective agent nimodipine (NMD) to brain tissue. NMD loaded Lf-NLC was optimized to exhibit a small and uniform particle size distribution and high loading content. Read More

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http://dx.doi.org/10.1016/j.msec.2018.02.004DOI Listing
November 2018

Co-Administration of Progesterone and Melatonin Attenuates Ischemia-Induced Hippocampal Damage in Rats.

J Mol Neurosci 2018 Oct 4;66(2):251-260. Epub 2018 Sep 4.

Tehran University of Medical Sciences, Tehran, Iran.

Stroke is the second leading reason for death worldwide and is one of the fundamental causes of long-term disabilities. The aim of this investigation was to assess the impact of combined administration progesterone (PROG) and melatonin (MEL) on stroke complications. Male Wistar rats (9-10 weeks) weighing 250-300 g were used as a part of this examination. Read More

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http://dx.doi.org/10.1007/s12031-018-1163-6DOI Listing
October 2018
7 Reads
2.343 Impact Factor

Plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses TNF-α/NF-κB pathway induced inflammation and matrix metalloproteinase-2/9 expression in rat cerebral ischemia.

Saudi J Biol Sci 2018 Sep 14;25(6):1033-1039. Epub 2017 Mar 14.

Department of Neurology, Linyi People's Hospital, Linyi 276003, Shandong, China.

Cerebral ischemic damage and infarction are well documented in stroke, which is presenting a foremost health concern globally with very high mortality and morbidity rates. Mechanisms that are associated with excitotoxicity, inflammation and oxidative stress are found to be critically involved in ischemic damage. Adverse effects of current therapies are imposing the need in development of neuroprotective agents that are very effective. Read More

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http://dx.doi.org/10.1016/j.sjbs.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116857PMC
September 2018
4 Reads

Comparison of Effects between Clopidogrel and Cilostazol on Cerebral Perfusion in Nonsurgical Adult Patients with Symptomatically Ischemic Moyamoya Disease: Subanalysis of a Prospective Cohort.

J Stroke Cerebrovasc Dis 2018 Nov 31;27(11):3373-3379. Epub 2018 Aug 31.

Department of Neurosurgery, Iwate Medical University, Morioka, Japan; Cyclotron Research Center, Iwate Medical University, Morioka, Japan. Electronic address:

Background And Purpose: Adult patients with symptomatically ischemic moyamoya disease (MMD) initially undergo medical treatment alone including antiplatelet drugs when symptomatic cerebral hemispheres do not exhibit hemodynamic compromise. The purpose of the present study subanalyzing the same patient cohort used in a previous study was to determine which antiplatelet drug, clopidogrel or cilostazol, provides better improvement of cerebral perfusion in such patients.

Methods: All patients without cerebral misery perfusion on O gas positron emission tomography (PET) did not undergo revascularization surgery and were treated with medication alone, including antiplatelet therapy. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.041DOI Listing
November 2018
1 Read

A facile approach for synthesis of nano-CeO particles loaded co-polymer matrix and their colossal role for blood-brain barrier permeability in Cerebral Ischemia.

J Photochem Photobiol B 2018 Oct 3;187:184-189. Epub 2018 May 3.

Department of Neurosurgery, Huaihe Hospital of Henan University, Kaifeng, Henan Province, 475000, China.

A prospective resource of pharmacological treatment of ischemic brains stroke is rapid interference using potential neuroprotective materials. Cerium oxide nanoparticles have been shown to defend against blood brain barrier damage in cerebral ischemic brain stroke. While cerium oxide nanoparticles is highly permeable across the blood-brain barrier and also these nanoparticles are effective antioxidants, due to its ability to either donate or obtain electrons with alternative +3 and +4 valence states. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2018.05.003DOI Listing
October 2018

Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date.

Drug Des Devel Ther 2018 15;12:2539-2552. Epub 2018 Aug 15.

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA,

Glyburide (also known as glibenclamide) is a second-generation sulfonylurea drug that inhibits sulfonylurea receptor 1 (Sur1) at nanomolar concentrations. Long used to target K (Sur1-Kir6.2) channels for the treatment of diabetes mellitus type 2, glyburide was recently repurposed to target Sur1-transient receptor potential melastatin 4 (Trpm4) channels in acute central nervous system injury. Read More

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http://dx.doi.org/10.2147/DDDT.S150043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101021PMC
December 2018
8 Reads

Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders.

J Mol Neurosci 2018 Oct 25;66(2):197-206. Epub 2018 Aug 25.

West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.

Ferroptosis is a recently defined form of cell death with the involvement of iron and reactive oxygen species (ROS), which is distinct from apoptosis, autophagy and other forms of cell death. Emerging evidence suggested that iron accumulation and lipid peroxidation can be discovered in various neurological diseases, accompanied with reduction of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In addition, ferroptotic inhibitors have been shown to protect neurons, and recover the cognitive function in disease animal models. Read More

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http://dx.doi.org/10.1007/s12031-018-1155-6DOI Listing
October 2018
12 Reads

Neuroprotective Action of the CB1/2 Receptor Agonist, WIN 55,212-2, against DMSO but Not Phenobarbital-Induced Neurotoxicity in Immature Rats.

Neurotox Res 2018 Aug 24. Epub 2018 Aug 24.

Department of Pharmacology and Physiology, Georgetown University, Washington, DC, 20007, USA.

The developing brain is uniquely susceptible to drug-induced increases in programmed cell death or apoptosis. Many compounds, including anticonvulsant drugs, anesthetic agents, and ethanol, when administered in a narrow postnatal window in rodents, result in increased pruning of neurons. Here, we report that dimethyl sulfoxide (DMSO) triggers widespread neurodegeneration in the immature (postnatal day, P7) rat brain, an effect consistent with a prior report in neonatal mice. Read More

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http://dx.doi.org/10.1007/s12640-018-9944-9DOI Listing
August 2018
2 Reads

[An experimental evaluation of the therapeutic window of the neuroprotective activity of a low-molecular nerve growth factor mimetic GK-2].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(7):49-53

Zakusov Research Institute of Pharmacology, Moscow, Russia.

Aim: To identify the time interval for the preservation of the effect of GK-2 depending on the start of administration after modeling ischemic stroke by the transient occlusion of the middle cerebral artery in rats.

Material And Methods: The experiments were performed on 33 wild-type male rats and 81 male Wistar rats. Animals were kept in standard conditions. Read More

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http://dx.doi.org/10.17116/jnevro20181187149DOI Listing
January 2018

The Effects of Mouse Recombinant Resistin on mRNA Expression of Proinflammatory and Anti-Inflammatory Cytokines and Heat Shock Protein-70 in Experimental Stroke Model.

J Stroke Cerebrovasc Dis 2018 Nov 16;27(11):3272-3279. Epub 2018 Aug 16.

Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Background: Our recent research showed that resistin has a neuroprotective effect against stroke-induced injury through suppressing apoptosis and oxidative stress. However, the molecular mechanism of neuroprotection of resistin is unclear. This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.030DOI Listing
November 2018
3 Reads
1.993 Impact Factor

Neuroprotective role of fucoxanthin against cerebral ischemic/reperfusion injury through activation of Nrf2/HO-1 signaling.

Biomed Pharmacother 2018 Oct 24;106:1484-1489. Epub 2018 Jul 24.

Department of Neurology, Jining No.1 People's Hospital, Jining City, Shandong Province, China. Electronic address:

In the present study, an attempt was made to determine whether administration of fucoxanthin could attenuate cerebral ischemic/reperfusion (I/R) injury and its possible mechanisms using an in vivo middle cerebral artery occlusion (MCAO) model and an in vitro oxygen-glucose deprivation and reoxygenation (OGD/R) model. Fucoxanthin was intragastrically administrated in different doses (30 mg/kg, 60 mg/kg, and 90 mg/kg, respectively) to the rats 1 h before MCAO induction. The neurological function, infarct area and brain water content of rats were then evaluated. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.07.088DOI Listing
October 2018
9 Reads

From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives.

Pharmacol Res 2018 Sep 11;135:201-211. Epub 2018 Aug 11.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. Electronic address:

Discovering effective agents to slow or stop neurodegeneration is a challenging task. Over decades, only a few drugs were approved by Food and Drug Administration (FDA) and most ended in failure. The lessons learned have switched the strategy of drug discovery from designing highly selective ligands to a network pharmacology approach. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.08.007DOI Listing
September 2018
4 Reads

Fullerenol Nanoparticles Decrease Blood-Brain Barrier Interruption and Brain Edema during Cerebral Ischemia-Reperfusion Injury Probably by Reduction of Interleukin-6 and Matrix Metalloproteinase-9 Transcription.

J Stroke Cerebrovasc Dis 2018 Nov 7;27(11):3053-3065. Epub 2018 Aug 7.

Department of Nanotechnology, School of New Sciences and Technology, Islamic Aazad University Pharmaceutical Sciences Branch, Tehran.

Background: The present study aimed to examine the protective role of fullerenol nanoparticles against blood-brain barrier (BBB) interruption and brain edema during cerebral ischemia-reperfusion injury probably by reduction of interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) transcription.

Methods: The male Wistar rats (weighting 280-320 g) were randomly assigned into four groups as follows: sham, control ischemic, pretreated ischemic, and posttreated ischemic groups. Cerebral ischemia-reperfusion (IR) injury was performed by occlusion of middle cerebral artery (MCA) for 90 minutes followed by twenty-four hours reperfusion. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.042DOI Listing
November 2018

Efficacy of Cilostazol in Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis.

J Stroke Cerebrovasc Dis 2018 Nov 6;27(11):2979-2985. Epub 2018 Aug 6.

Department of Neurology, Wayne State University/Detroit Medical Center, Detroit, MI.

Objectives: Cilostazol, a selective inhibitor of phosphodiesterase 3, may reduce symptomatic vasospasm and improve outcome in patients with aneurysmal subarachnoid hemorrhage considering its anti-platelet and vasodilatory effects. We aimed to analyze the effects of cilostazol on symptomatic vasospasm and clinical outcome among patients with aneurysmal subarachnoid hemorrhage (aSAH).

Patients And Methods: We searched PubMed and Embase databases to identify 1) prospective randomized trials, and 2) retrospective trials, between May 2009 and May 2017, that investigated the effect of cilostazol in patients with aneurysmal aSAH. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.027DOI Listing
November 2018
10 Reads

Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquaporin 4.

J Stroke Cerebrovasc Dis 2018 Nov 6;27(11):3247-3255. Epub 2018 Aug 6.

Department of Neurology, The Second Affiliated Hospital of Nanchang University, China. Electronic address:

Background: Cerebral edema, a serious complication of acute cerebral infarction, has a crucial impact on morbidity and mortality in the early stage of cerebral infarction. And aquaporin 4 (AQP4), a bidirectional water transporting protein, plays a pivotal role in edema formation. At experimental model, it has proven that atorvastatin could exert pleiotropic neuroprotection on acute cerebral infarction independent of its cholesterol-lowering action. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.07.011DOI Listing
November 2018
12 Reads

Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice.

J Stroke Cerebrovasc Dis 2018 Nov 3;27(11):3084-3094. Epub 2018 Aug 3.

Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan. Electronic address:

Background: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both potentials of thrombolytic and neuroprotective effects, but its detailed neuroprotective mechanisms in ischemic stroke are still unclear. Here, we assessed the neuroprotective effects of SMTP-7 for anti-inflammatory and antiapoptosis mechanisms after 60 minutes of transient middle cerebral artery occlusion (tMCAO) in mice.

Methods: After 60minutes of tMCAO, 0. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.039DOI Listing
November 2018
1 Read
1.990 Impact Factor

The neuroprotective effects and probable mechanisms of Ligustilide and its degradative products on intracerebral hemorrhage in mice.

Int Immunopharmacol 2018 Oct 31;63:43-57. Epub 2018 Jul 31.

Department of Pharmacology & Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address:

Background: Intracerebral hemorrhage (ICH) is a common neurological emergency with higher mortality and disability rate than cerebral ischemia. Although diverse therapeutic interventions have been explored for potential neuroprotection from ICH, no effective drugs until now are available for improvement of survival rate or the life quality of survivors after ICH. Just like cerebral ischemia, inflammatory mechanism is highly thought to play a vital role in hemorrhagic brain injury. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.06.045DOI Listing
October 2018
5 Reads

Combination Therapy with LXW7 and Ceria Nanoparticles Protects against Acute Cerebral Ischemia/Reperfusion Injury in Rats.

Curr Med Sci 2018 Feb 15;38(1):144-152. Epub 2018 Mar 15.

Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, 518000, China.

Ischemia/reperfusion is known to greatly increase oxidative stress in the penumbra, which results in brain damage. Integrin αvβ3 is selectively up-regulated with ischemic injury to the brain and remains elevated throughout reperfusion. We determined whether or not a new compound biotinylated-LXW7-ceria nanoparticle (CeNP) (bLXW7-CeNP) plays a role in brain protection in the rat model of middle cerebral artery occlusion/reperfusion and shows better effects than CeNPs alone in improving the outcomes of focal oxidative stress and apoptosis more effectively. Read More

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http://dx.doi.org/10.1007/s11596-018-1858-5DOI Listing
February 2018
2 Reads

SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury.

Med Sci Monit 2018 Aug 3;24:5391-5397. Epub 2018 Aug 3.

Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).

BACKGROUND Activation of AKT pathway attenuates brain damage and neuronal apoptosis during cerebral ischemia/reperfusion (I/R) injury. SC79 is a novel, selective and highly-efficient Akt activator. This study aimed to investigate the neuroprotective effect of SC79 against cerebral I/R injury in a rat model, and to explore the possible underlying mechanisms. Read More

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http://dx.doi.org/10.12659/MSM.910191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087033PMC
August 2018
1 Read

Role of Steroid Therapy after Ischemic Stroke by n-Methyl-d-Aspartate Receptor Gene Regulation.

J Stroke Cerebrovasc Dis 2018 Nov 30;27(11):3066-3075. Epub 2018 Jul 30.

Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

Background: Stroke is the main cause of cerebrovascular disease mortality. Prolonged stimulation of n-methyl-d-aspartate (NMDA) receptor subtypes by the accumulation of glutamate neurotransmitter in the extracellular space after a stroke could activate cell death pathways. It is reported that progesterone provides different mechanisms of neuroprotection and could be considered as a candidate for stroke treatment. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.06.041DOI Listing
November 2018
1 Read