323 results match your criteria Neuromodulation Surgery for Psychiatric Disorders


Risk Factors and Survival Analysis of Spinal Cord Stimulator Explantation.

Neuromodulation 2020 Jun 3. Epub 2020 Jun 3.

Department of Epidemiology, University of Iowa, Iowa City, IA, USA.

Objective: The treatment failure rate for spinal cord stimulators (SCS) remains unacceptably high, with reports of removal in up to 30% of patients. The purpose of this study is to perform survival and multivariate regression analyses of patients who have undergone SCS explantation in order to identify patient characteristics that may predict treatment failure.

Materials And Methods: We identified 253 patients who underwent SCS placement using current procedural terminology codes in a private health insurance data base spanning 2003-2016. Read More

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http://dx.doi.org/10.1111/ner.13173DOI Listing

Single-Session of Combined tDCS-TMS May Increase Therapeutic Effects in Subjects With Tinnitus.

Front Neurol 2020 27;11:160. Epub 2020 Mar 27.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam-si, South Korea.

To treat motor and psychiatric disorders, transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are used in clinics worldwide. We combined these two types of neuromodulation technique to increase the effective response of a single session of neuromodulation in subjective tinnitus. Eighty tinnitus subjects were split into four different treatment groups: tDCS, tDCS with sham TMS, tDCS-TMS, and TMS group. Read More

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http://dx.doi.org/10.3389/fneur.2020.00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118567PMC

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.

Authors:
Azmeraw T Amare Klaus Oliver Schubert Liping Hou Scott R Clark Sergi Papiol Micah Cearns Urs Heilbronner Franziska Degenhardt Fasil Tekola-Ayele Yi-Hsiang Hsu Tatyana Shekhtman Mazda Adli Nirmala Akula Kazufumi Akiyama Raffaella Ardau Bárbara Arias Jean-Michel Aubry Lena Backlund Abesh Kumar Bhattacharjee Frank Bellivier Antonio Benabarre Susanne Bengesser Joanna M Biernacka Armin Birner Clara Brichant-Petitjean Pablo Cervantes Hsi-Chung Chen Caterina Chillotti Sven Cichon Cristiana Cruceanu Piotr M Czerski Nina Dalkner Alexandre Dayer Maria Del Zompo J Raymond DePaulo Bruno Étain Stephane Jamain Peter Falkai Andreas J Forstner Louise Frisen Mark A Frye Janice M Fullerton Sébastien Gard Julie S Garnham Fernando S Goes Maria Grigoroiu-Serbanescu Paul Grof Ryota Hashimoto Joanna Hauser Stefan Herms Per Hoffmann Andrea Hofmann Esther Jiménez Jean-Pierre Kahn Layla Kassem Po-Hsiu Kuo Tadafumi Kato John R Kelsoe Sarah Kittel-Schneider Sebastian Kliwicki Barbara König Ichiro Kusumi Gonzalo Laje Mikael Landén Catharina Lavebratt Marion Leboyer Susan G Leckband Alfonso Tortorella Mirko Manchia Lina Martinsson Michael J McCarthy Susan L McElroy Francesc Colom Marina Mitjans Francis M Mondimore Palmiero Monteleone Caroline M Nievergelt Markus M Nöthen Tomas Novák Claire O'Donovan Norio Ozaki Urban Ösby Andrea Pfennig James B Potash Andreas Reif Eva Reininghaus Guy A Rouleau Janusz K Rybakowski Martin Schalling Peter R Schofield Barbara W Schweizer Giovanni Severino Paul D Shilling Katzutaka Shimoda Christian Simhandl Claire M Slaney Alessio Squassina Thomas Stamm Pavla Stopkova Mario Maj Gustavo Turecki Eduard Vieta Julia Veeh Stephanie H Witt Adam Wright Peter P Zandi Philip B Mitchell Michael Bauer Martin Alda Marcella Rietschel Francis J McMahon Thomas G Schulze Bernhard T Baune

Mol Psychiatry 2020 Mar 16. Epub 2020 Mar 16.

Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.

Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtained from 2586 bipolar patients who received lithium treatment and took part in the Consortium on Lithium Genetics (ConLiGen) study. Read More

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http://dx.doi.org/10.1038/s41380-020-0689-5DOI Listing

Purinergic Signaling and Related Biomarkers in Depression.

Brain Sci 2020 Mar 12;10(3). Epub 2020 Mar 12.

Department of Medicine and Surgery, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy.

It is established that purinergic signaling can shape a wide range of physiological functions, including neurotransmission and neuromodulation. The purinergic system may play a role in the pathophysiology of mood disorders, influencing neurotransmitter systems and hormonal pathways of the hypothalamic-pituitary-adrenal axis. Treatment with mood stabilizers and antidepressants can lead to changes in purinergic signaling. Read More

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http://dx.doi.org/10.3390/brainsci10030160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139781PMC

Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation.

Neural Regen Res 2020 Aug;15(8):1437-1450

Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education of the People's Republic of China, Tongji University; Spine Surgery Division of Department of Orthopedics, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Spinal cord injury is linked to the interruption of neural pathways, which results in irreversible neural dysfunction. Neural repair and neuroregeneration are critical goals and issues for rehabilitation in spinal cord injury, which require neural stem cell repair and multimodal neuromodulation techniques involving personalized rehabilitation strategies. Besides the involvement of endogenous stem cells in neurogenesis and neural repair, exogenous neural stem cell transplantation is an emerging effective method for repairing and replacing damaged tissues in central nervous system diseases. Read More

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http://dx.doi.org/10.4103/1673-5374.274332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059565PMC

Tractographic description of major subcortical projection pathways passing the anterior limb of the internal capsule. Corticopetal organization of networks relevant for psychiatric disorders.

Neuroimage Clin 2020 11;25:102165. Epub 2020 Jan 11.

Department of Stereotactic and Functional Neurosurgery, Freiburg University Medical Center and Medical Faculty of Freiburg University, Breisacher Strasse 64, Freiburg im Breisgau 79106, Germany.

Background: Major depression (MD) and obsessive-compulsive disorder (OCD) are psychiatric diseases with a huge impact on individual well-being. Despite optimal treatment regiments a subgroup of patients remains treatment resistant and stereotactic surgery (stereotactic lesion surgery, SLS or Deep Brain Stimulation, DBS) might be an option. Recent research has described four networks related to MD and OCD (affect, reward, cognitive control, default network) but only on a cortical and the adjacent sub-cortical level. Read More

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http://dx.doi.org/10.1016/j.nicl.2020.102165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965747PMC
January 2020

A novel tDCS sham approach based on model-driven controlled shunting.

Brain Stimul 2020 Mar - Apr;13(2):507-516. Epub 2019 Nov 9.

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Italy; Berenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique able to transiently modulate brain activity, is surging as one of the most promising therapeutic solutions in many neurological and psychiatric disorders. However, profound limitations exist in current placebo (sham) protocols that limit single- and double-blinding, especially in non-naïve subjects.

Objective: To ensure better blinding and strengthen reliability of tDCS studies and trials, we tested a new optimization algorithm aimed at creating an "active" sham tDCS condition (ActiSham hereafter) capable of inducing the same scalp sensations perceived during real stimulation while preventing currents from reaching the cortex and cause changes in brain excitability. Read More

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http://dx.doi.org/10.1016/j.brs.2019.11.004DOI Listing
November 2019

Bouncing back: Brain rehabilitation amid opioid and stimulant epidemics.

Neuroimage Clin 2019 5;24:102068. Epub 2019 Nov 5.

Laureate Institute for Brain Research, Tulsa, OK, United States; Department of Community Medicine, University of Tulsa, Tulsa, OK, United States.

Recent methamphetamine and opioid use epidemics are a major public health concern. Chronic stimulant and opioid use are characterized by significant psychosocial, physical and mental health costs, repeated relapse, and heightened risk of early death. Neuroimaging research highlights deficits in brain processes and circuitry that are linked to responsivity to drug cues over natural rewards as well as suboptimal goal-directed decision-making. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.102068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978215PMC
November 2019

Clinical trials for deep brain stimulation: Current state of affairs.

Brain Stimul 2020 Mar - Apr;13(2):378-385. Epub 2019 Nov 23.

Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Deep brain stimulation (DBS) is a surgical neuromodulation procedure with a historically wide range of possible therapeutic indications, including movement disorders, neuropsychiatric conditions, and cognitive disorders. Ongoing research in this field is critical to gain further insights into the mechanisms of DBS, to discover novel brain targets for new and existing indications, and to refine targeting and post-operative programming techniques for the optimization of therapeutic outcomes.

Objective: To update on the state of DBS-related clinical human research by cataloging and summarizing clinical trials that have been completed or are currently ongoing in this field worldwide. Read More

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http://dx.doi.org/10.1016/j.brs.2019.11.008DOI Listing
November 2019

Deep brain stimulation: new possibilities for the treatment of mental disorders.

Psychiatr Pol 2019 Aug 31;53(4):789-806. Epub 2019 Aug 31.

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Katedra i Klinika Neurochirurgii.

Deep brain stimulation (DBS) is a treatment method that is currently getting more and more attention from psychiatrists. It has proven to be efficacious and safe in the treatment of neurological disorders, mainly Parkinson's disease (PD), dystonia and essential tremor. DBS has very often contributed to successful treatment in cases that had proved resistant to all other methods of treatment. Read More

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http://dx.doi.org/10.12740/PP/OnlineFirst/103090DOI Listing

Nucleus Accumbens as a Novel Target for Deep Brain Stimulation in the Treatment of Addiction: A Hypothesis on the Neurochemical and Morphological Basis.

Neurol India 2019 Sep-Oct;67(5):1220-1224

Department of Neurosurgery, University of Illinois at Chicago, Chicago,IL, USA.

Addiction is a major cause of mortality and morbidity. Apart from psychotropic substances, alcohol and nicotine remain the common addictive materials responsible for the majority of deaths. Conventional conservative therapies are beneficial to certain populations, but the majority may require interventional treatments such as deep brain stimulation (DBS) in view of increasing mortality from drug abuse in recent years. Read More

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http://dx.doi.org/10.4103/0028-3886.271239DOI Listing

Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.

Mol Psychiatry 2019 Nov 11. Epub 2019 Nov 11.

Centre for Human Genetics, University of Marburg, Marburg, Germany.

Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. Read More

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http://dx.doi.org/10.1038/s41380-019-0590-2DOI Listing
November 2019
14.496 Impact Factor

Ethical Challenges of Risk, Informed Consent, and Posttrial Responsibilities in Human Research With Neural Devices: A Review.

JAMA Neurol 2019 Oct 17. Epub 2019 Oct 17.

Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia.

Importance: Developing more and better diagnostic and therapeutic tools for central nervous system disorders is an ethical imperative. Human research with neural devices is important to this effort and a critical focus of the National Institutes of Health Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Despite regulations and standard practices for conducting ethical research, researchers and others seek more guidance on how to ethically conduct neural device studies. Read More

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http://dx.doi.org/10.1001/jamaneurol.2019.3523DOI Listing
October 2019
1 Read

Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics.

Front Neurosci 2019 12;13:936. Epub 2019 Sep 12.

Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.

The annual deep brain stimulation (DBS) Think Tank aims to create an opportunity for a multidisciplinary discussion in the field of neuromodulation to examine developments, opportunities and challenges in the field. The proceedings of the Sixth Annual Think Tank recapitulate progress in applications of neurotechnology, neurophysiology, and emerging techniques for the treatment of a range of psychiatric and neurological conditions including Parkinson's disease, essential tremor, Tourette syndrome, epilepsy, cognitive disorders, and addiction. Each section of this overview provides insight about the understanding of neuromodulation for specific disease and discusses current challenges and future directions. Read More

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http://dx.doi.org/10.3389/fnins.2019.00936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751331PMC
September 2019
1 Read

Economic evaluation of deep-brain stimulation for Tourette's syndrome: an initial exploration.

J Neurol 2019 Dec 4;266(12):2997-3008. Epub 2019 Sep 4.

Asia-Pacific Centre for Neuromodulation, Queensland Brain Institute, The University of Queensland, Brisbane, Australia.

Background: Deep-brain stimulation (DBS) can be effective in controlling medically intractable symptoms of Tourette's syndrome (TS). There is no evidence to date, though, of the potential cost-effectiveness of DBS for this indication.

Objective: To provide the first estimates of the likely cost-effectiveness of DBS in the treatment of severe TS. Read More

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http://dx.doi.org/10.1007/s00415-019-09521-8DOI Listing
December 2019

Network Basis of Seizures Induced by Deep Brain Stimulation: Literature Review and Connectivity Analysis.

World Neurosurg 2019 Dec 23;132:314-320. Epub 2019 Aug 23.

University Health Network, Toronto, Ontario, Canada. Electronic address:

Background: Whereas transient, self-limiting seizures are an infrequent but known complication of deep brain stimulation (DBS) implantation surgery, stimulation itself has occasionally been reported to result in seizure activity at delayed time points. The neural circuitry implicated in stimulation-induced seizures is unknown.

Case Description: A 47-year-old woman underwent chronic subcallosal cingulate DBS for treatment of refractory anorexia nervosa and experienced seizure with stimulation onset. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.094DOI Listing
December 2019
2 Reads
2.417 Impact Factor

Frontal white matter architecture predicts efficacy of deep brain stimulation in major depression.

Transl Psychiatry 2019 08 21;9(1):197. Epub 2019 Aug 21.

Department of Stereotactic and Functional Neurosurgery, Freiburg University Medical Center, Freiburg, Germany.

Major depression is a frequent and severe disorder, with a combination of psycho- and pharmacotherapy most patients can be treated. However, ~20% of all patients suffering from major depressive disorder remain treatment resistant; a subgroup might be treated with deep brain stimulation (DBS). We present two trials of DBS to the superolateral medial forebrain bundle (slMFB DBS; FORESEE I and II). Read More

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http://dx.doi.org/10.1038/s41398-019-0540-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704187PMC
August 2019
4 Reads
4.360 Impact Factor

Essential tremor: diagnosis and management.

Authors:
Vicki Shanker

BMJ 2019 Aug 5;366:l4485. Epub 2019 Aug 5.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Essential tremor is one of the most common movement disorders in adults and can affect both children and adults. An updated consensus statement in 2018 redefined essential tremor as an isolated action tremor present in bilateral upper extremities for at least three years. Tremor may also be present in other locations, commonly the neck or the vocal cords. Read More

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http://dx.doi.org/10.1136/bmj.l4485DOI Listing
August 2019
2 Reads

Surgical decision making for deep brain stimulation should not be based on aggregated normative data mining.

Brain Stimul 2019 Nov - Dec;12(6):1345-1348. Epub 2019 Jul 22.

Department of Clinical Neuroscience, University Hospital, 90185, Umeå, Sweden.

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http://dx.doi.org/10.1016/j.brs.2019.07.014DOI Listing
February 2020
2 Reads

Field potential 1/ activity in the subcallosal cingulate region as a candidate signal for monitoring deep brain stimulation for treatment-resistant depression.

J Neurophysiol 2019 09 17;122(3):1023-1035. Epub 2019 Jul 17.

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.

Subcallosal cingulate cortex deep brain stimulation (SCC-DBS) is an experimental therapy for treatment-resistant depression (TRD). Refinement and optimization of SCC-DBS will benefit from increased study of SCC electrophysiology in context of ongoing high-frequency SCC-DBS therapy. The study objective was a 7-mo observation of frequency-domain 1/ slope in off-stimulation local field potentials (SCC-LFPs) alongside standardized measurements of depression severity in 4 patients undergoing SCC-DBS. Read More

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http://dx.doi.org/10.1152/jn.00875.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766743PMC
September 2019

Stimuli, presentation modality, and load-specific brain activity patterns during n-back task.

Hum Brain Mapp 2019 09 9;40(13):3810-3831. Epub 2019 Jun 9.

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Siena, Italy.

Working memory (WM) refers to a set of cognitive processes that allows for the temporary storage and manipulation of information, crucial for everyday life skills. WM deficits are present in several neurological, psychiatric, and neurodevelopmental disorders, thus making the full understanding of its neural correlates a key aspect for the implementation of cognitive training interventions. Here, we present a quantitative meta-analysis focusing on the underlying neural substrates upon which the n-back, one of the most commonly used tasks for WM assessment, is believed to rely on, as highlighted by functional magnetic resonance imaging and positron emission tomography findings. Read More

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http://dx.doi.org/10.1002/hbm.24633DOI Listing
September 2019
12 Reads

Consensus Paper: Experimental Neurostimulation of the Cerebellum.

Cerebellum 2019 Dec;18(6):1064-1097

Department of Pathology and Immunology, Department of Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX, 77030, USA.

The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscored by its involvement in a diverse and increasing number of neurological and neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson's disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Read More

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http://dx.doi.org/10.1007/s12311-019-01041-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867990PMC
December 2019
27 Reads

Magnetic Resonance-Guided Focused Ultrasound for Psychiatric Disorders.

Clin Pharmacol Ther 2019 10 24;106(4):720-722. Epub 2019 May 24.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpt.1467DOI Listing
October 2019
5 Reads

A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders.

Transl Psychiatry 2019 05 23;9(1):150. Epub 2019 May 23.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Major depressive disorder and the anxiety disorders are highly prevalent, disabling and moderately heritable. Depression and anxiety are also highly comorbid and have a strong genetic correlation (r ≈ 1). Cognitive behavioural therapy is a leading evidence-based treatment but has variable outcomes. Read More

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http://dx.doi.org/10.1038/s41398-019-0481-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533285PMC
May 2019
12 Reads
4.360 Impact Factor

Can cognitive decline be the nemesis of motor improvement secondary to deep brain stimulation?

Neurol India 2019 Mar-Apr;67(2):393-394

Department of Neurological Surgery, Center for Neuromodulation, Neuroscience Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.4103/0028-3886.258016DOI Listing
February 2020

Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans.

BMC Neurosci 2019 04 29;20(1):20. Epub 2019 Apr 29.

Department of Neurology, University Hospital of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.

Background: Prepulse inhibition (PPI) of the acoustic startle response, a measurement of sensorimotor gaiting, is modulated by monoaminergic, presumably dopaminergic neurotransmission. Disturbances of the dopaminergic system can cause deficient PPI as found in neuropsychiatric diseases. A target specific influence of deep brain stimulation (DBS) on PPI has been shown in animal models of neuropsychiatric disorders. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-019-0503-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489177PMC
April 2019
15 Reads

Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats.

PLoS Comput Biol 2019 04 22;15(4):e1006838. Epub 2019 Apr 22.

Department of Psychiatry, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, United States of America.

The ventral striatum (VS) is a central node within a distributed network that controls appetitive behavior, and neuromodulation of the VS has demonstrated therapeutic potential for appetitive disorders. Local field potential (LFP) oscillations recorded from deep brain stimulation (DBS) electrodes within the VS are a pragmatic source of neural systems-level information about appetitive behavior that could be used in responsive neuromodulation systems. Here, we recorded LFPs from the bilateral nucleus accumbens core and shell (subregions of the VS) during limited access to palatable food across varying conditions of hunger and food palatability in male rats. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497302PMC
April 2019
11 Reads

Psychiatric Neurosurgery: A Survey on the Perceptions of Psychiatrists and Residents.

Can J Neurol Sci 2019 05 12;46(3):303-310. Epub 2019 Apr 12.

Department of Psychiatry, McGill University Health Center,McGill University,Montreal, Quebec,Canada.

Objectives: To evaluate the attitudes and perceptions of psychiatrists and psychiatry residents regarding neurosurgical procedures for treating psychiatric disorders and to identify potential barriers to patient referral.

Methods: A survey consisting of 25 questions was created using SurveyMonkey and was distributed to psychiatrists and psychiatry residents in Quebec. The study was approved by the McGill University Health Center's Research Ethics Board. Read More

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http://dx.doi.org/10.1017/cjn.2019.5DOI Listing
May 2019
13 Reads

Safety of transcranial direct current stimulation in a patient with deep brain stimulation electrodes.

Arq Neuropsiquiatr 2019 03;77(3):174-178

Universidade de Brasília, Departamento de Ciências Fisiológicas, Instituto de Biologia, Brasília DF, Brasil.

Background: Transcranial direct current stimulation (tDCS) has been investigated in movement disorders, making it a therapeutic alternative in clinical settings. However, there is still no consensus on the most appropriate treatment protocols in most cases, and the presence of deep brain stimulation (DBS) electrodes has been regarded as a contraindication to the procedure. We recently studied the effects of cerebellar tDCS on a female patient already undergoing subthalamic nucleus deep brain stimulation (STN-DBS) for generalized dystonia. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/0004-282X20190019DOI Listing
March 2019
14 Reads

Spinal Cord Stimulation for Restless Legs Syndrome: Case Series and Mechanistic Hypothesis.

Stereotact Funct Neurosurg 2019 4;97(1):31-36. Epub 2019 Apr 4.

Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA,

Background: Spinal cord stimulation (SCS) is a well-established therapy for chronic pain syndromes, with growing applicability to other conditions. Restless legs syndrome (RLS) is a widespread, chronic movement disorder managed primarily and incompletely by medication, and its etiology can be classified as idiopathic or secondary.

Methods: Three patients underwent SCS implantation for chronic back and/or leg pain with concomitant targeting of RLS: (1) a 34-year-old man with sporadic RLS symptoms that strongly intensified after military-related spinal fractures, (2) a 54-year-old man with RLS likely secondary to meralgia paresthetica, and (3) a 42-year-old man with low back and right lower extremity pain after a military motor vehicle accident. Read More

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https://www.karger.com/Article/FullText/494737
Publisher Site
http://dx.doi.org/10.1159/000494737DOI Listing
February 2020
24 Reads

Current therapies and therapeutic decision making for childhood-onset movement disorders.

Mov Disord 2019 05 28;34(5):637-656. Epub 2019 Mar 28.

Kids Neuroscience Centre, The Kids Research Institute at the Children's Hospital at Westmead, Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.

Movement disorders differ in children to adults. First, neurodevelopmental movement disorders such as tics and stereotypies are more prevalent than parkinsonism, and second, there is a genomic revolution which is now explaining many early-onset dystonic syndromes. We outline an approach to children with movement disorders starting with defining the movement phenomenology, determining the level of functional impairment due to abnormal movements, and screening for comorbid psychiatric conditions and cognitive impairments which often contribute more to disability than the movements themselves. Read More

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http://dx.doi.org/10.1002/mds.27661DOI Listing
May 2019
13 Reads

Deep Brain Stimulation for Depression: An Emerging Indication.

Neurosurg Clin N Am 2019 Apr 18;30(2):243-256. Epub 2019 Feb 18.

Department of Neurosurgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

Depression is a heterogenous disorder, with roughly 30% of patients deemed resistant to conventional treatments. In these cases, neurosurgical interventions such as lesion procedures or deep brain stimulation offer possible therapeutic options. Here, we review neurosurgical interventions for treatment-resistant depression, focusing on the recent advancements and future directions of deep brain stimulation. Read More

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http://dx.doi.org/10.1016/j.nec.2018.12.007DOI Listing
April 2019
5 Reads

Optogenetic Stimulation of the M2 Cortex Reverts Motor Dysfunction in a Mouse Model of Parkinson's Disease.

J Neurosci 2019 04 19;39(17):3234-3248. Epub 2019 Feb 19.

Centro de Tecnologia em Medicina Molecular,

Neuromodulation of deep brain structures (deep brain stimulation) is the current surgical procedure for treatment of Parkinson's disease (PD). Less studied is the stimulation of cortical motor areas to treat PD symptoms, although also known to alleviate motor disturbances in PD. We were able to show that optogenetic activation of secondary (M2) motor cortex improves motor functions in dopamine-depleted male mice. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2277-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788829PMC
April 2019
35 Reads

Connectivity Profile Predictive of Effective Deep Brain Stimulation in Obsessive-Compulsive Disorder.

Biol Psychiatry 2019 05 9;85(9):735-743. Epub 2019 Jan 9.

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany; Department of Psychiatry and Psychotherapy, Johanniter Hospital Oberhausen, Oberhausen, Germany.

Background: Deep brain stimulation for obsessive-compulsive disorder is a rapidly developing treatment strategy for treatment-refractory patients. Both the exact target and impact on distributed brain networks remain a matter of debate. Here, we investigated which regions connected to stimulation sites contribute to clinical improvement effects and whether connectivity is able to predict outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193000
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http://dx.doi.org/10.1016/j.biopsych.2018.12.019DOI Listing
May 2019
20 Reads

Indian guidelines on neurosurgical interventions in psychiatric disorders.

Indian J Psychiatry 2019 Jan-Feb;61(1):13-21

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Neurosurgery for psychiatric disorders (NPD) has been practiced for >80 years. However, the interests have waxed and waned, from 1000s of surgeries in 1940-1950s to handful of surgery in 60-80s. This changed with the application of deep brain stimulation surgery, a surgery, considered to be "reversible" there has been a resurgence in interest. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_536_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341921PMC
February 2019
12 Reads

Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels.

Int J Mol Med 2019 Apr 28;43(4):1747-1757. Epub 2019 Jan 28.

Department of Anesthesiology, The First Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

The cardiopulmonary bypass (CPB) is an important risk factor for the development of postoperative cognitive dysfunction (POCD). The pathological mechanism of the neuro‑modulation receptor degradation protein ring finger protein 41 (Nrdp1) in CPB‑induced cognitive dysfunction remains unclear. In the present study, aged Sprague‑Dawley male rats and CPB treatment were selected to duplicate the POCD model. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4080
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http://dx.doi.org/10.3892/ijmm.2019.4080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414174PMC
April 2019
22 Reads

EuroInf 2: Subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease.

Mov Disord 2019 03 4;34(3):353-365. Epub 2019 Feb 4.

National Parkinson Foundation International Centre of Excellence, King's College Hospital, London, United Kingdom.

Objective: Real-life observational report of clinical efficacy of bilateral subthalamic stimulation (STN-DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on quality of life, motor, and nonmotor symptoms (NMS) in Parkinson's disease (PD).

Methods: In this prospective, multicenter, international, real-life cohort observation study of 173 PD patients undergoing STN-DBS (n = 101), IJLI (n = 33), or APO (n = 39) were followed-up using PDQuestionnaire-8, NMSScale (NMSS), Unified PD Rating Scale (UPDRS)-III, UPDRS-IV, and levodopa equivalent daily dose (LEDD) before and 6 months after intervention. Outcome changes were analyzed with Wilcoxon signed-rank or paired t test when parametric tests were applicable. Read More

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http://dx.doi.org/10.1002/mds.27626DOI Listing
March 2019
10 Reads

Deep brain stimulation: potential for neuroprotection.

Ann Clin Transl Neurol 2019 01 8;6(1):174-185. Epub 2018 Nov 8.

Krembil Research Institute University Health Network Toronto Western Hospital Toronto Ontario Canada.

Over the last two decades there has been an exponential rise in the number of patients receiving deep brain stimulation (DBS) to manage debilitating neurological symptoms in conditions such as Parkinson's disease, essential tremor, and dystonia. Novel applications of DBS continue to emerge including treatment of various psychiatric conditions (e.g. Read More

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http://dx.doi.org/10.1002/acn3.682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331208PMC
January 2019
9 Reads

Eternal sunshine of the neuromodulated mind: Altering fear memories through neuromodulation.

Exp Neurol 2019 04 10;314:9-19. Epub 2019 Jan 10.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:

Anxiety disorders pose one of the greatest threats to mental health. Modern treatment methods exist but are hindered by relapse, toxicity, and low efficacy. The use of neuromodulation to treat anxiety disorders has shown promising results, yet its underpinning mechanisms remain poorly understood. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.01.004DOI Listing
April 2019
18 Reads

CM-Pf deep brain stimulation and the long term management of motor and psychiatric symptoms in a case of Tourette syndrome.

J Clin Neurosci 2019 Apr 3;62:269-272. Epub 2019 Jan 3.

Functional Neurosurgery and DBS, Centro Chirurgico Toscano, Via dei Lecci, 22, 52100 Arezzo, Italy.

Tourette syndrome is a rare neuropsychiatric disorder affecting the cortico-striato-thalamo-cortical system. The disease manifests in childhood with tics and various psychiatric comorbidities. Cases of refractory Tourette syndrome are valuable candidates for functional neurosurgery. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.12.029DOI Listing
April 2019
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Leveraging Neuroplasticity to Enhance Adaptive Learning: The Potential for Synergistic Somatic-Behavioral Treatment Combinations to Improve Clinical Outcomes in Depression.

Biol Psychiatry 2019 03 20;85(6):454-465. Epub 2018 Sep 20.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

Until recently, therapeutic development in psychiatry was targeted solely toward symptom reduction. While this is a worthwhile goal, it has yielded little progress in improved therapeutics in the last several decades in the field of mood disorders. Recent advancements in our understanding of pathophysiology suggests that an impairment of neuroplasticity may be a critical part of the development of neuropsychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380941PMC
March 2019
4 Reads

The Role of Cognitive Reserve in Alzheimer's Disease and Aging: A Multi-Modal Imaging Review.

J Alzheimers Dis 2018 ;66(4):1341-1362

Brain Investigation and Neuromodulation Lab, Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Italy.

Comforts in modern society have generally been associated with longer survival rates, enabling individuals to reach advanced age as never before in history. With the increase in longevity, however, the incidence of neurodegenerative diseases, especially Alzheimer's disease, has also doubled. Nevertheless, most of the observed variance, in terms of time of clinical diagnosis and progression, often remains striking. Read More

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http://dx.doi.org/10.3233/JAD-180549DOI Listing
November 2019
2 Reads

Multiple-therapy-resistant major depressive disorder: a clinically important concept.

Br J Psychiatry 2018 05;212(5):274-278

Centre for Affective Disorders,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London and South London and Maudsley NHS Foundation Trust,London.

Many novel therapeutic options for depression exist that are either not mentioned in clinical guidelines or recommended only for use in highly specialist services. The challenge faced by clinicians is when it might be appropriate to consider such 'non-standard' interventions. This analysis proposes a framework to aid this decision. Read More

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http://dx.doi.org/10.1192/bjp.2017.33DOI Listing
May 2018
6 Reads

Transcranial direct current stimulation to prevent and treat surgery-induced opioid dependence: a systematic review.

Pain Manag 2019 Jan 5;9(1):93-106. Epub 2018 Dec 5.

Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, 02129, USA.

Opioid misuse leading to dependence is a major health issue. Recent studies explored valid alternatives to treat pain in postsurgical settings. This systematic review aims to discuss the role of transcranial direct current stimulation (tDCS) in preventing and treating postoperative pain and opioid dependence. Read More

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http://dx.doi.org/10.2217/pmt-2018-0053DOI Listing
January 2019
6 Reads

Novel Concept Enabling an Old Idea: A Flexible Electrode Array to Treat Neurogenic Erectile Dysfunction.

J Sex Med 2018 11;15(11):1558-1569

National and Kapodistrian University of Athens, Medical School, 1st Urology Department, Laikon Hospital, Athens, Greece.

Introduction: Many studies have shown that electrostimulation of the cavernosal nerve can induce and maintain penile erection. Based on these discoveries, neurostimulation to activate the erectile response has been considered a potential solution to treat erectile dysfunction (ED). However, despite recognized potential, this technology has not been further developed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17436095183116
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http://dx.doi.org/10.1016/j.jsxm.2018.09.003DOI Listing
November 2018
37 Reads

Is Molecular Inflammatory Profiling a Useful Tool for Personalized Brain Stimulation in Psychiatric Disorders?

Neuromodulation 2018 Dec 5;21(8):826-827. Epub 2018 Nov 5.

Department of Psychiatry, Division of Medical Psychology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/ner.12881DOI Listing
December 2018
4 Reads

Neuromodulation: Past, Present, and Future.

Child Adolesc Psychiatr Clin N Am 2019 01 18;28(1):xi-xii. Epub 2018 Sep 18.

Child and Adolescent Services, Sheppard Pratt Health System, 6501 North Charles Street, Baltimore, MD 21204, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chc.2018.08.003DOI Listing
January 2019
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Electroconvulsive Therapy and Other Neuromodulation Techniques for the Treatment of Psychosis.

Child Adolesc Psychiatr Clin N Am 2019 01 31;28(1):91-100. Epub 2018 Aug 31.

Department of Psychiatry, Vanderbilt University Medical Center, Vanderbilt Psychiatric Hospital, 1601 23rd Avenue South, Nashville, TN 37212, USA.

Electroconvulsive therapy is an established treatment for symptoms of psychosis and is currently recommended for use in patients who are experiencing an acute exacerbation of positive symptoms or who have had catatonia. There is also evidence to suggest that electroconvulsive therapy can be a safe, effective treatment in first episode psychosis, such as schizophrenia spectrum disorders, particularly in treatment-resistant patients. Other forms of neuromodulation (transcranial magnetic stimulation, transcranial direct current stimulation, vagus nerve stimulation, deep brain stimulation) have less of an evidence base to support their use and are not formally indicated for the treatment of psychosis. Read More

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http://dx.doi.org/10.1016/j.chc.2018.07.004DOI Listing
January 2019
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Chronic fornix deep brain stimulation in a transgenic Alzheimer's rat model reduces amyloid burden, inflammation, and neuronal loss.

Brain Struct Funct 2019 Jan 19;224(1):363-372. Epub 2018 Oct 19.

Université Côte d'Azur, INSERM, CNRS/UMR7275, IPMC, Team Labeled "Laboratory of Excellence (LABEX) Distalz", 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

Recent studies have suggested deep brain stimulation (DBS) as a promising therapy in patients with Alzheimer's disease (AD). Particularly, the stimulation of the forniceal area was found to slow down the cognitive decline of some AD patients, but the biochemical and anatomical modifications underlying these effects remain poorly understood. We evaluated the effects of chronic forniceal stimulation on amyloid burden, inflammation, and neuronal loss in a transgenic Alzheimer rat model TgF344-AD, as well as in age-matched control rats. Read More

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http://dx.doi.org/10.1007/s00429-018-1779-xDOI Listing
January 2019
5 Reads

Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.

Acta Anaesthesiol Scand 2018 11;62(10):1473-1480

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderly patients after anaesthesia and surgery, and cognitive changes have been identified up to 7. Read More

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http://dx.doi.org/10.1111/aas.13250DOI Listing
November 2018
10 Reads