8,724 results match your criteria Neuromodulation: Technology at the Neural Interface [Journal]


Status of Noninvasive Brain Stimulation in the Therapy of Alzheimer's Disease.

Chin Med J (Engl) 2018 Dec;131(24):2899-2903

Department of Neurology, Xuanwu Hospital, Capital Medical University; Beijing Key Laboratory of Neuromodulation, Beijing 100053; Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China.

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December 2018
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Prefronto-cerebellar neuromodulation affects appetite in obesity.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Bariatric and Nutritional Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Human neuroimaging studies have consistently reported changes in cerebellar function and integrity in association with obesity. To date, however, the nature of this link has not been studied directly. Emerging evidence suggests a role for the cerebellum in higher cognitive functions through reciprocal connections with the prefrontal cortex. Read More

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December 2018

Hiccups amelioration following a transcranial direct current stimulation protocol targeting central structures.

Aust N Z J Psychiatry 2018 Dec 11:4867418816823. Epub 2018 Dec 11.

1 The Clinical Neuromodulation Laboratory, Santa Casa School of Medical Sciences, São Paulo, Brazil.

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December 2018

[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018
3 Reads

Sacral neuromodulation: standardized tined lead implantation technique: two-year clinical outcome and sensory response upon lead stimulation comparing the use of the curved versus straight stylet.

BJU Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology, Antwerp University Hospital, Edegem, Belgium.

Objectives: To assess clinical follow-up data over 24 months using the standardized tined lead implantation technique, comparing the use of the curved vs straight stylet.

Patients And Methods: Single tertiary center, prospective study (August 2013 - June 2015) involving 40 patients with overactive bladder and 15 with non-obstructive urinary retention refractory to first-line treatment.

Primary Outcome: successful tined lead procedure; intention to treat analysis at 12 and 24 months. Read More

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December 2018

Trial Versus No Trial of Spinal Cord Stimulation for Chronic Neuropathic Pain: Cost Analysis in United Kingdom National Health Service.

Neuromodulation 2018 Dec 10. Epub 2018 Dec 10.

Basildon and Thurrock University Hospitals, Basildon, UK.

Objectives: The aim of the current project was to evaluate the spinal cord stimulation (SCS) screening trial success rate threshold to obtain the same cost impact across two identical sets of patients following either a prolonged screening trial prior to implantation strategy or a full implant without a screening trial.

Materials And Methods: A cost impact analysis was carried out from a health care perspective and considered trial to implant rates reported in the literature. Items of resource use were costed using national averages obtained from the National Health Service (NHS) reference cost data base. Read More

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December 2018

A chemogenetic approach for treating experimental Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: PD is a common neurodegenerative disease primarily affecting the cortico-basal ganglia loop.

Objective: To investigate whether chemogenetic-mediated neuromodulation of various nuclei and pathways can counterbalance basal ganglia network abnormalities and improve motor disability in experimental PD.

Methods: Experimental PD was induced by stereotactic injection of 6-OHDA to the medial forebrain bundle. Read More

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December 2018
3 Reads

Determinants for Meaningful Clinical Improvement of Pain and Health-Related Quality of Life After Spinal Cord Stimulation for Chronic Intractable Pain.

Neuromodulation 2018 Dec 10. Epub 2018 Dec 10.

Center for Applied Neuroscience (CeNAp), University Hospital (HU), Federal University of Santa Catarina State (UFSC), Florianópolis, SC, Brazil.

Objectives: Previous studies demonstrated significant improvement in mean pain scores and quality of life (QOL) scales in patients with chronic pain who underwent spinal cord stimulation (SCS). However, the number of individuals who experience relevant improvements in QOL, termed the meaningful clinical improvement (MCI), is not known. The present study investigated changes in pain measurements based on MCI after SCS. Read More

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December 2018

The American Headache Society Position Statement On Integrating New Migraine Treatments Into Clinical Practice.

Authors:

Headache 2018 Dec 10. Epub 2018 Dec 10.

Objective: To provide healthcare professionals with updated guidance in the use of novel preventive and acute treatments for migraine in adults.

Background: The principles of preventive and acute pharmacotherapy for patients with migraine have been outlined previously, but the emergence of new technologies and treatments, as well as new formulations of previously established treatments, has created a need for an updated guidance on the preventive and acute treatment of migraine.

Methods: This statement is based on a review of existing guidelines and principles for preventive and acute treatment of migraine, as well as the results of recent clinical trials of drugs and devices for these indications. Read More

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December 2018
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Efficacy of Invasive and Non-Invasive Brain Modulation Interventions for Addiction.

Neuropsychol Rev 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychiatry, Academic Medical Center, University of Amsterdam, PA3.227, PO box 22660, 1100DD, Amsterdam, The Netherlands.

It is important to find new treatments for addiction due to high relapse rates despite current interventions and due to expansion of the field with non-substance related addictive behaviors. Neuromodulation may provide a new type of treatment for addiction since it can directly target abnormalities in neurocircuits. We review literature on five neuromodulation techniques investigated for efficacy in substance related and behavioral addictions: transcranial direct current stimulation (tDCS), (repetitive) transcranial magnetic stimulation (rTMS), EEG, fMRI neurofeedback and deep brain stimulation (DBS) and additionally report on effects of these interventions on addiction-related cognitive processes. Read More

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December 2018
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Sacral neuromodulation and sexual function: a systematic review and meta-analysis of the literature.

Int Urogynecol J 2018 Dec 7. Epub 2018 Dec 7.

James Cook University Hospital, Middlesbrough, TS4 3BW, UK.

Introduction And Hypothesis: Sexual function is being increasingly recognized as an important patient-reported outcome. Sacral neuromodulation (SNM) is a treatment with an expanding list of indications. The effect of sacral neuromodulation on sexual function has been examined in a number of studies with variable results. Read More

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December 2018

The first Iraqi experience in sacral neuromodulation for patients with lower urinary tract dysfunction.

Arab J Urol 2018 Dec 7;16(4):391-396. Epub 2018 Aug 7.

Department of Neurosurgery, Al-Mustansiriya University, Baghdad, Iraq.

Objectives: To present our experience, in Iraq, with sacral neuromodulation (SNM) in patients with refractory lower urinary tract dysfunction, with discussion of the factors that affect the response rate.

Patients And Methods: In this prospective, clinical, interventional study, 24 patients were evaluated and treated by a team comprised of a Urologist and a Neurosurgeon with SNM over a 1.5-year period. Read More

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December 2018

Intermittent Theta Burst Stimulation Over Ventral Premotor Cortex or Inferior Parietal Lobule Does Not Enhance the Rubber Hand Illusion.

Front Neurosci 2018 23;12:870. Epub 2018 Nov 23.

Research Unit of Neurophysiology and Neuroengineering of Human-Technology Interaction, Università Campus Bio-Medico, Rome, Italy.

An enhanced sense of prosthesis ownership may be the key for higher amputees' quality of life. In this study in 28 healthy subjects, neuronavigated intermittent Theta Burst Stimulation (iTBS) delivered over the right ventral premotor cortex or inferior parietal lobule has been tested, compared to sham stimulation, to enhance embodiment in the rubber hand illusion paradigm. Neuromodulation of both areas did not result in an enhancement of embodiment, as assessed by the results collected from a self-evaluation questionnaire for the extent of self-attribution of the rubber hand and proprioceptive drift. Read More

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November 2018

Nil effects of μ-rhythm phase-dependent burst-rTMS on cortical excitability in humans: A resting-state EEG and TMS-EEG study.

PLoS One 2018 7;13(12):e0208747. Epub 2018 Dec 7.

Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Repetitive transcranial magnetic stimulation (rTMS) can induce excitability changes of a stimulated brain area through synaptic plasticity mechanisms. High-frequency (100 Hz) triplets of rTMS synchronized to the negative but not the positive peak of the ongoing sensorimotor μ-rhythm isolated with the concurrently acquired electroencephalography (EEG) resulted in a reproducible long-term potentiation like increase of motor evoked potential (MEP) amplitude, an index of corticospinal excitability (Zrenner et al. 2018, Brain Stimul 11:374-389). Read More

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December 2018

Opportunities and challenges for developing closed-loop bioelectronic medicines.

Neural Regen Res 2019 Jan;14(1):46-50

Medical Devices and Neuromodulation, Battelle Memorial Institute, Columbus, OH, USA.

The peripheral nervous system plays a major role in the maintenance of our physiology. Several peripheral nerves intimately regulate the state of the brain, spinal cord, and visceral systems. A new class of therapeutics, called bioelectronic medicines, are being developed to precisely regulate physiology and treat dysfunction using peripheral nerve stimulation. Read More

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January 2019

Leveraging Neuroplasticity to Enhance Adaptive Learning: The Potential for Synergistic Somatic-Behavioral Treatment Combinations to Improve Clinical Outcomes in Depression.

Biol Psychiatry 2018 Sep 20. Epub 2018 Sep 20.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

Until recently, therapeutic development in psychiatry was targeted solely toward symptom reduction. While this is a worthwhile goal, it has yielded little progress in improved therapeutics in the last several decades in the field of mood disorders. Recent advancements in our understanding of pathophysiology suggests that an impairment of neuroplasticity may be a critical part of the development of neuropsychiatric disorders. Read More

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September 2018

Neuromodulation - science and practice in epilepsy: Vagus nerve stimulation, thalamic deep brain stimulation, and responsive neurostimulation.

Expert Rev Neurother 2018 Dec 11:1-13. Epub 2018 Dec 11.

a Department of Neurology and Neurological Sciences , Stanford University School of Medicine , Stanford , CA , USA.

Introduction: Neuromodulation devices can be safe and effective for the treatment of drug-resistant epilepsy. A body of scientific work supports peripheral, subcortical and cortical targets, each with different fundamental methods of action. Areas covered: High-quality evidence is available for vagal nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS). Read More

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December 2018

Interleaving programming in pallidal deep brain stimulation improves outcomes in a patient with Meige syndrome.

Br J Neurosurg 2018 Dec 11:1-2. Epub 2018 Dec 11.

a Beijing Institute of Function Neurosurgery , Xuanwu Hospital, Capital Medical University , Xicheng , Beijing , China.

We present the effectiveness of interleaving programming in pallidal deep brain stimulation in a patient with Meige syndrome. This patient's symptoms were initially inadequately relieved by conventional programming methods. Then, we switched to the interleaving programming strategy, which produced an individual electrical density and improved her symptoms significantly. Read More

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December 2018

Migraine and Tension-Type Headache.

Semin Neurol 2018 Dec 6;38(6):608-618. Epub 2018 Dec 6.

Department of Neurology, Boston Medical Center, Boston, Massachusetts.

Migraine and tension-type headache (TTH) are common primary disorders that carry significant morbidity and socioeconomic effect. In this article, we will review the epidemiology, presentation, and diagnosis of these disorders. First-line acute treatment for migraine consists of analgesics, triptans, and antiemetics, while nonsteroidal anti-inflammatory drugs are the mainstay treatment for TTH. Read More

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December 2018
2 Reads

Structure and function of dual-source cholinergic modulation in early vision.

J Comp Neurol 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina.

Behavioral states such as arousal and attention have profound effects on sensory processing, determining how - even whether - a stimulus is perceived. This state-dependence is believed to arise, at least in part, in response to inputs from subcortical structures that release neuromodulators such as acetylcholine, often non-synaptically. The mechanisms that underlie the interaction between these non-synaptic signals and the more point-to-point synaptic cortical circuitry are not well understood. Read More

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December 2018

Multilevel diffusion tensor imaging classification technique for characterizing neurobehavioral disorders.

Brain Imaging Behav 2018 Dec 5. Epub 2018 Dec 5.

Institute for Biological and Medical Engineering, Schools of Engineering, Biology and Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

This proposed novel method consists of three levels of analyses of diffusion tensor imaging data: 1) voxel level analysis of fractional anisotropy of white matter tracks, 2) connection level analysis, based on fiber tracks between specific brain regions, and 3) network level analysis, based connections among multiple brain regions. Machine-learning techniques of (Fisher score) feature selection, (Support Vector Machine) pattern classification, and (Leave-one-out) cross-validation are performed, for recognition of the neural connectivity patterns for diagnostic purposes. For validation proposes, this multilevel approach achieved an average classification accuracy of 90% between Alzheimer's disease and healthy controls, 83% between Alzheimer's disease and mild cognitive impairment, and 83% between mild cognitive impairment and healthy controls. Read More

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December 2018
6 Reads

Transcriptional changes in the Japanese scallop (Mizuhopecten yessoensis) shellinfested by Polydora provide insights into the molecular mechanism of shell formation and immunomodulation.

Sci Rep 2018 Dec 5;8(1):17664. Epub 2018 Dec 5.

Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian, China.

The Japanese scallop (Mizuhopecten yessoensis) is one of the most important aquaculture species in Asian countries; however, it has suffered severe infection by Polydora in northern China in recent years, causing great economic losses. The Polydora parasitizes the shell of scallops, badly destroying the shell's structure. To investigate the molecular response mechanism of M. Read More

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December 2018
4 Reads

Association of Seizure Spread With Surgical Failure in Epilepsy.

JAMA Neurol 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut.

Importance: Seizures recur in as many as half of patients who undergo surgery for drug-resistant temporal lobe epilepsy (TLE). Understanding why TLE is resistant to surgery in some patients may reveal insights into epileptogenic networks and direct new therapies to improve outcomes.

Objective: To characterize features of surgically refractory TLE. Read More

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December 2018
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The Role of Cognitive Reserve in Alzheimer's Disease and Aging: A Multi-Modal Imaging Review.

J Alzheimers Dis 2018 Nov 26. Epub 2018 Nov 26.

Brain Investigation and Neuromodulation Lab, Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Italy.

Comforts in modern society have generally been associated with longer survival rates, enabling individuals to reach advanced age as never before in history. With the increase in longevity, however, the incidence of neurodegenerative diseases, especially Alzheimer's disease, has also doubled. Nevertheless, most of the observed variance, in terms of time of clinical diagnosis and progression, often remains striking. Read More

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November 2018
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Progress in noninvasive, abortive neuromodulation therapy for treating acute pain in primary headache disorders.

Pain Manag 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology & Critical Care Medicine, Division of Pain Medicine. The Johns Hopkins University School of Medicine, Baltimore, MD, USA, 21287.

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December 2018
3 Reads

Effects of Tonic Spinal Cord Stimulation on Sensory Perception in Chronic Pain Patients: A Systematic Review.

Neuromodulation 2018 Dec 2. Epub 2018 Dec 2.

Centre de recherche du CHU de Québec - Université Laval, Axe neurosciences, Quebec city, Quebec, Canada.

Objectives: Even if spinal cord stimulation (SCS) is widely used and effective in treating intractable chronic neuropathic pain conditions, little is known about its possible impacts on sensory perception. Quantitative sensory testing (QST) is a useful tool to assess this issue. The aim of this study was to review the impact of tonic SCS on somatosensory perception quantified by QST in chronic pain patients. Read More

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December 2018

Intrapallidal injection of botulinum toxin A recovers gait deficits in a parkinsonian rodent model.

Acta Physiol (Oxf) 2018 Dec 3:e13230. Epub 2018 Dec 3.

Department of Physiology and Pharmacology, Western University, London, Ontario, Canada.

Aim: Modulation of electrical activity in the subthalamic nucleus has been therapeutically effective in Parkinson's disease. Pharmacological manipulation of glutamate release from subthalamic neurons could also favourably alter basal ganglia activity to improve motor symptoms. The present study investigates the efficacy of selective suppression of hyperactive glutamatergic input from the subthalamic nucleus to the globus pallidus internal segment by botulinum toxin A (BoNT-A) in a parkinsonian model. Read More

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December 2018
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Cathodal Skin Lesions Induced by Transcranial Direct Current Stimulation (tDCS).

Neuromodulation 2018 Dec 2. Epub 2018 Dec 2.

Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, China.

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December 2018

Effect of Early Sacral Neuromodulation on Bladder Function in a Rat Model of Incomplete Spinal Cord Injury Due to Focal Contusion.

Neuromodulation 2018 Dec 2. Epub 2018 Dec 2.

Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.

Objectives: Incomplete spinal cord injury (SCI) accounts for two-thirds of all SCIs in clinical practice. Preclinical research on the effect of sacral neuromodulation (SNM) on bladder function, however, has been focused only on animal models of complete SCI. We aimed to evaluate the effect of early SNM on bladder responses in a rat model of incomplete SCI. Read More

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December 2018
1 Read

A Case of Pocket Fill Causing Baclofen Withdrawal.

Neuromodulation 2018 Dec 2. Epub 2018 Dec 2.

EHC-Hôpital de Morges, Morges, Switzerland.

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December 2018

Use of a Double-Cone Coil in Transcranial Magnetic Stimulation for Depression Treatment.

Neuromodulation 2018 Dec 2. Epub 2018 Dec 2.

Neuropsychiatry, Behavioral Science Postgraduate Program at the Universidade Federal de Pernambuco, Recife, Brazil.

Introduction: Approximately 15% of all people will experience a depressive episode throughout their lives, and by 2020, depression will be the second largest cause of disability around the world. Transcranial magnetic stimulation (TMS) has been shown to be an effective option for treating this condition. Devices such as the double-cone coil may bring new insights regarding depression treatment. Read More

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December 2018
3 Reads

Preliminary Findings on the Optimization of Visual Performance in Patients with Age-Related Macular Degeneration Using Biofeedback Training.

Appl Psychophysiol Biofeedback 2018 Nov 30. Epub 2018 Nov 30.

Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.

Biofeedback training has been used to improve fixation stability in subjects with central vision loss, but the psychophysiological mechanisms underlying the functional improvements resulted was not reported. The aim of this study was to investigate the effects of microperimetric biofeedback training on different visual functions and self-reported quality of vision in subjects with age-related macular degeneration. This case-control study included six subjects (72. Read More

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November 2018

Feasibility of using a novel non-invasive ambulatory tibial nerve stimulation device for the home-based treatment of overactive bladder symptoms.

Transl Androl Urol 2018 Dec;7(6):912-919

Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery and UCL Institute of Neurology, London, UK.

Background: To evaluate safety, acceptability and pilot efficacy of transcutaneous low-frequency tibial nerve stimulation (TNS) using a novel device as home-based neuromodulation.

Methods: In this single-centre pilot study, 48 patients with overactive bladder (OAB) (24 with neurogenic and 24 with idiopathic OAB) were randomized to use a self-applicating ambulatory skin-adhering device stimulating transcutaneously the tibial nerve at 1 Hz for 30 minutes, either once daily or once weekly, for 12 weeks. Changes in OAB symptoms and QoL were measured at baseline, weeks 4, 8, and 12 using validated scoring instruments (ICIQ-OAB and ICIQ-LUTSqol), 3-day bladder diary and a Global Response Assessment (GRA) at week 12. Read More

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December 2018
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Glial responses to implanted electrodes in the brain.

Nat Biomed Eng 2017 Nov 10;1(11):862-877. Epub 2017 Nov 10.

Department of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.

The use of implants that can electrically stimulate or record electrophysiological or neurochemical activity in nervous tissue is rapidly expanding. Despite remarkable results in clinical studies and increasing market approvals, the mechanisms underlying the therapeutic effects of neuroprosthetic and neuromodulation devices, as well as their side effects and reasons for their failure, remain poorly understood. A major assumption has been that the signal-generating neurons are the only important target cells of neural-interface technologies. Read More

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November 2017
1 Read

Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals.

Brain Stimul 2018 Nov 17. Epub 2018 Nov 17.

School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea. Electronic address:

Background: Current transcranial ultrasound stimulation for small animal in vivo experiment is limited to acute stimulation under anesthesia in stereotaxic fixation due to bulky and heavy curved transducers.

Methods: We developed a miniaturized ultrasound ring array transducer which is capable of invoking motor responses through neuromodulation of freely-moving awake mice.

Results: The developed transducer is a 32-element, 183-kHz ring array with a weight of 0. Read More

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November 2018
1 Read

Ultrasound-responsive droplets for therapy: A review.

J Control Release 2018 Nov 29;293:144-154. Epub 2018 Nov 29.

Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.

The last two decades have seen the development of acoustically activated droplets, also known as phase-change emulsions, from a diagnostic tool to a therapeutic agent. Through bubble effects and triggered drug release, these superheated agents have found potential applications from oncology to neuromodulation. The aim of this review is to summarise the key developments in therapeutic droplet design and use, to discuss the current challenges slowing clinical translation, and to highlight the new frontiers progressing towards clinical implementation. Read More

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November 2018
5 Reads

Concomitant Behavioral and Prefrontal Cortex Neuronal Responses Following Acute and Chronic Methylphenidate Exposure in Adolescent and Adult Rats.

Brain Res Bull 2018 Nov 28. Epub 2018 Nov 28.

University of Texas McGovern Medical School at Houston, Department of Neurobiology and Anatomy, 6431 Fannin Street, Houston TX, 77030, United States. Electronic address:

There is growing concern that the psychostimulant Methylphenidate (MPD) is being abused for cognitive enhancement and recreation by healthy adults and adolescents seeking to improve their work or academic performance. This study concomitantly recorded the behavioral and prefrontal cortex (PFC) neuronal activity in freely behaving animals exposed to acute and chronic MPD doses (0.6, 2. Read More

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November 2018
1 Read

Spatial characteristics of spontaneous and stimulus-induced individual functional connectivity networks in severe disorders of consciousness.

Brain Cogn 2018 Nov 27. Epub 2018 Nov 27.

Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany. Electronic address:

Background: Functional connectivity (fcMRI) analyses of resting state functional magnetic resonance imaging (fMRI) data revealed substantial differences between states of consciousness. The underlying cause-effect linkage, however, remains unknown to the present day. The aim of this study was to examine the relationship between fcMRI measures and Disorders of Consciousness (DOC) in resting state and under adequate stimulation. Read More

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November 2018

Developing an optimized strategy with transcranial direct current stimulation to enhance the endogenous pain control system in fibromyalgia.

Expert Rev Med Devices 2018 Dec 3;15(12):863-873. Epub 2018 Dec 3.

a Laboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation , Spaulding Rehabilitation Hospital, Harvard Medical School , Boston , MA , USA.

Introduction: Fibromyalgia affects more than 5 million people in the United States and has a detrimental impact on individuals' quality of life. Current pharmacological treatments provide limited benefits to relieve the pain of fibromyalgia, along with a risk of adverse effects; a scenario that explains the increasing interest for multimodal approaches. A tailored strategy to focus on this dysfunctional endogenous pain inhibitory system is transcranial direct current stimulation (tDCS) of the primary motor cortex. Read More

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December 2018
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Multiple-therapy-resistant major depressive disorder: a clinically important concept.

Br J Psychiatry 2018 May;212(5):274-278

Centre for Affective Disorders,Institute of Psychiatry,Psychology and Neuroscience,King's College London,London and South London and Maudsley NHS Foundation Trust,London.

SummaryMany novel therapeutic options for depression exist that are either not mentioned in clinical guidelines or recommended only for use in highly specialist services. The challenge faced by clinicians is when it might be appropriate to consider such 'non-standard' interventions. This analysis proposes a framework to aid this decision. Read More

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May 2018
1 Read

Transcranial direct current stimulation to prevent and treat surgery-induced opioid dependence: a systematic review.

Pain Manag 2018 Dec 5. Epub 2018 Dec 5.

Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, 02129, USA.

Opioid misuse leading to dependence is a major health issue. Recent studies explored valid alternatives to treat pain in postsurgical settings. This systematic review aims to discuss the role of transcranial direct current stimulation (tDCS) in preventing and treating postoperative pain and opioid dependence. Read More

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December 2018

A Prospective Study of the Impact of Transcranial Alternating Current Stimulation on EEG Correlates of Somatosensory Perception.

Front Psychol 2018 20;9:2117. Epub 2018 Nov 20.

Department of Neuroscience, Brown University, Providence, RI, United States.

The (8-12 Hz) neocortical alpha rhythm is associated with shifts in attention across sensory systems, and is thought to represent a sensory gating mechanism for the inhibitory control of cortical processing. The present preliminary study sought to explore whether alpha frequency transcranial alternating current stimulation (tACS) could modulate endogenous alpha power in the somatosensory system, and whether the hypothesized modulation would causally impact perception of tactile stimuli at perceptual threshold. We combined electroencephalography (EEG) with simultaneous brief and intermittent tACS applied over primary somatosensory cortex at individuals' endogenous alpha frequency during a tactile detection task ( = 12 for EEG, = 20 for behavior). Read More

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November 2018
2 Reads

Novel Insights of Effects of Pregabalin on Neural Mechanisms of Intracortical Disinhibition in Physiopathology of Fibromyalgia: An Explanatory, Randomized, Double-Blind Crossover Study.

Front Hum Neurosci 2018 19;12:406. Epub 2018 Nov 19.

Post-Gradaution in Medical Science at Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

The fibromyalgia (FM) physiopathology involves an intracortical excitability/inhibition imbalance as measured by transcranial magnetic stimulation measures (TMS). TMS measures provide an index that can help to understand how the basal neuronal plasticity state (i.e. Read More

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November 2018
2 Reads

Two distinct profiles of fMRI and neurophysiological activity elicited by acetylcholine in visual cortex.

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, D-72076 Tübingen, Germany.

Cholinergic neuromodulation is involved in all aspects of sensory processing and is crucial for processes such as attention, learning and memory, etc. However, despite the known roles of acetylcholine (ACh), we still do not how to disentangle ACh contributions from sensory or task-evoked changes in functional magnetic resonance imaging (fMRI). Here, we investigated the effects of local injection of ACh on fMRI and neural signals in the primary visual cortex (V1) of anesthetized macaques by combining pharmaco-based MRI (phMRI) with electrophysiological recordings, using single electrodes and electrode arrays. Read More

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December 2018

Reframing the Role of Neuromodulation Therapy in the Chronic Pain Treatment Paradigm.

Pain Physician 2018 Nov;21(6):507-513

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Blaustein Pain Treatment Center, Johns Hopkins Hospital, Baltimore MD.

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November 2018
1 Read

Late life depression: nursing actions that can help.

Authors:
Sherri Melrose

Perspect Psychiatr Care 2018 Nov 30. Epub 2018 Nov 30.

Faculty of Health Disciplines, Centre for Nursing and Health Studies, Athabasca University, Athabasca, Alberta.

Purpose: This article explains the symptoms of late life depression (LLD) and discusses evidence-informed actions that nurses can implement to provide older adults with the help they need.

Conclusions: Recognizing and addressing depression in older adults can enhance quality of life.

Practice Implications: People with LLD may not appear sad or express feelings of depression. Read More

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November 2018
3 Reads

Predictors of successful percutaneous tibial nerve stimulation (PTNS) in the treatment of overactive bladder syndrome.

Int Urogynecol J 2018 Nov 29. Epub 2018 Nov 29.

Division of Urogynecology, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, 9650 Gross Point Road, Suite 3900, Skokie, IL, 60076, USA.

Introduction And Hypothesis: Multiple publications have demonstrated the efficacy of percutaneous tibial nerve stimulation (PTNS) for overactive bladder syndrome (OAB). However, patient characteristics associated with successful treatment have not been well established. The aim of this study was to identify prognostic factors for successful PTNS treatment. Read More

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November 2018