9,254 results match your criteria Neuromodulation: Technology at the Neural Interface [Journal]


Miniature electroparticle-cuff for wireless peripheral neuromodulation.

J Neural Eng 2019 Apr 24. Epub 2019 Apr 24.

Bioengineering, University of Texas at Dallas Erik Jonsson School of Engineering and Computer Science, 800 W. Campbell Rd., BSB 13.637, Richardson, Texas, 75080-3021, UNITED STATES.

Recent developments in peripheral nerve electrodes allow the efficient and selective neuromodulation of somatic and autonomic nerves, which has proven beneficial in specific bioelectronic medical applications. However, current most clinical devices are wired and powered by implantable batteries which suffer from several limitations. We recently developed a sub-millimeter inductively powered neural stimulator (electroparticle; EP), and in this study, we report the integration of the EP onto commercial cuff electrodes (EP-C) allowing the wireless activation of peripheral nerves. Read More

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http://dx.doi.org/10.1088/1741-2552/ab1c36DOI Listing

A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP.

PLoS Comput Biol 2019 Apr 24;15(4):e1006975. Epub 2019 Apr 24.

Institute of Biophysics, National Research Council, Palermo, Italy.

Across the mammalian nervous system, neurotrophins control synaptic plasticity, neuromodulation, and neuronal growth. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) is known to promote structural and functional synaptic plasticity in the hippocampus, the cerebral cortex, and many other brain areas. In recent years, a wealth of data has been accumulated revealing the paramount importance of BDNF for neuronal function. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006975DOI Listing

Manual or electroacupuncture as an add-on therapy to SSRIs for depression: A randomized controlled trial.

J Psychiatr Res 2019 Apr 9;114:24-33. Epub 2019 Apr 9.

Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese Medicine, Beijing, 100029, China. Electronic address:

Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants, however, only around 60% of patients could benefit from them. Acupuncture is supported by insufficient evidence to help with symptom relieving and SSRIs tolerance. This pragmatic randomized controlled trial compared SSRIs alone versus SSRIs together with manual acupuncture (MA) or electroacupuncture (EA) in moderate to severe depressed patients. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.04.005DOI Listing

Transcranial direct current stimulation treatment in chronic after-stroke dysphagia: A clinical case.

Psicothema 2019 May;31(2):179-183

Universidad de Almería, Instituto de Neurorehabilitación InPaula.

Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that has shown positive effects in a variety of motor diseases including dysphagia. However, its clinical application and underlying microstructural effects are still being researched. We tested whether tDCS applied together with swallowing training could benefit a treatment-resistent patient with dysphagia after a stroke. Read More

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http://dx.doi.org/10.7334/psicothema2018.310DOI Listing

The Accuracy and Feasibility of Robotic Assisted Lead Implantation in Nonhuman Primates.

Neuromodulation 2019 Apr 23. Epub 2019 Apr 23.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Objectives: Deep brain stimulation (DBS) and stereo-electroencephalography (SEEG) electrode implantation are the most important and frequent manipulations in nonhuman primates (NHP) neuromodulation research. However, traditional methods tend to be arduous and inaccurate.

Materials And Methods: Twelve adult male rhesus monkeys were selected for the study, with six subthalamic nucleus (STN) DBS, six anterior nucleus of the thalamus (ANT) DBS and six hippocampus-SEEG (Hippo-SEEG) electrodes implantation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ner.12951
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http://dx.doi.org/10.1111/ner.12951DOI Listing
April 2019
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[Express]A Novel Neuromodulation Strategy to Enhance the Prefrontal Control to Treat Pain.

Mol Pain 2019 Apr 23:1744806919845739. Epub 2019 Apr 23.

New York University Langone Medical Center.

Effective pharmacological treatment options for chronic pain remain very limited, and continued reliance on opioid analgesics has contributed to an epidemic in the U.S. On the other hand, non-pharmacologic neuromodulatory interventions provide a promising avenue for relief of chronic pain without the complications of dependence and addiction. Read More

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http://dx.doi.org/10.1177/1744806919845739DOI Listing

Feasibility of a Fully Implanted, Nickel Sized and Shaped Tibial Nerve Stimulator for the Treatment of Overactive Bladder Syndrome with Urgency Urinary Incontinence.

J Urol 2019 May;201(5):967-972

Medical University of South Carolina , Charleston , South Carolina.

Purpose: We performed a clinical feasibility trial to evaluate the safety and efficacy of a fully implanted, primary battery powered, nickel sized and shaped neuromodulation device called the eCoin® for tibial nerve stimulation to treat refractory urgency urinary incontinence.

Materials And Methods: This prospective, single arm, open label study included 46 participants with refractory urgency urinary incontinence. It was performed at multiple sites in the United States and New Zealand. Read More

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http://www.jurology.com/doi/10.1016/j.juro.2018.10.017
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http://dx.doi.org/10.1016/j.juro.2018.10.017DOI Listing
May 2019
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Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats.

PLoS Comput Biol 2019 Apr 22;15(4):e1006838. Epub 2019 Apr 22.

Department of Psychiatry, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, United States of America.

The ventral striatum (VS) is a central node within a distributed network that controls appetitive behavior, and neuromodulation of the VS has demonstrated therapeutic potential for appetitive disorders. Local field potential (LFP) oscillations recorded from deep brain stimulation (DBS) electrodes within the VS are a pragmatic source of neural systems-level information about appetitive behavior that could be used in responsive neuromodulation systems. Here, we recorded LFPs from the bilateral nucleus accumbens core and shell (subregions of the VS) during limited access to palatable food across varying conditions of hunger and food palatability in male rats. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006838DOI Listing

Lesion Localization of Poststroke Lateropulsion.

Stroke 2019 May;50(5):1067-1073

Iowa Neuroimaging and Noninvasive Brain Stimulation Laboratory, Departments of Pediatrics, Neurology & Psychiatry, University of Iowa Hospitals and Clinics, Iowa City (F.M.A., A.D.B.).

Background and Purpose- Hemispheric stroke studies associating lateropulsion (pusher syndrome) with the location of brain lesions have had mixed results from small, unmatched samples. This study was designed to determine whether lateropulsion localizes to specific brain regions across patients with stroke using a case-control design. Methods- Fifty patients with lateropulsion after stroke were matched with 50 stroke patients without lateropulsion using age, time since onset of stroke, admission motor Functional Independence Measure score, lesion side, and gender. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023445DOI Listing

A Retrospective Database Review of the Indications, Complications, and Incidence of Subsequent Spine Surgery in 12,297 Spinal Cord Stimulator Patients.

Neuromodulation 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.

Study Design: Retrospective review.

Objective: To analyze the indications, incidence of minor and major complications, and rate of subsequent spinal surgery or revision after spinal cord stimulator (SCS) placement for degenerative spine disease.

Summary Of Background Data: Despite the application of SCS in various chronic pain conditions, there remains a growing debate on the efficacy and necessity of SCS in degenerative spine disease. Read More

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http://dx.doi.org/10.1111/ner.12952DOI Listing

Pilot trial of home-administered transcranial direct current stimulation for the treatment of depression.

J Affect Disord 2019 Apr 10;252:475-483. Epub 2019 Apr 10.

School of Psychiatry, University of New South Wales/Black Dog Institute, Hospital Road, Randwick, NSW 2031, Australia; St George Hospital, South Eastern Sydney Health, Level 2, James Laws House, Gray St, Kogarah, NSW 2217, Australia.

Background: Transcranial Direct Current Stimulation (tDCS) is a non-invasive, neuromodulation approach with promising efficacy for treating depression. To date, tDCS has been limited to clinical or research centre settings with treatment administered by staff. The aim of this study is to examine the efficacy, tolerability and feasibility of home-administered, remotely-supervised tDCS for depression. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.041DOI Listing
April 2019
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Levetiracetam-induced a new seizure type in a girl with a novel SV2A gene mutation.

Clin Neurol Neurosurg 2019 Mar 28;181:64-66. Epub 2019 Mar 28.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; The Beijing Key Laboratory of Neuromodulation, Beijing 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorder, Beijing 100069, China; Department of Pediatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Electronic address:

The target brain binding site of levetiracetam (LEV) is synaptic vesicle glycoprotein 2A (SV2A). Up to now, only a homozygous pathogenic SV2A gene mutation was reported in human. We now report a novel heterozygous pathogenic SV2A gene mutation both in a girl and her mother result in epilepsy and poor response to LEV. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193008
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http://dx.doi.org/10.1016/j.clineuro.2019.03.020DOI Listing
March 2019
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Therapeutic interventions in patients with prolonged disorders of consciousness.

Lancet Neurol 2019 Apr 16. Epub 2019 Apr 16.

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium.

The management of patients with severe brain injuries and prolonged disorders of consciousness raises important issues particularly with respect to their therapeutic options. The scarcity of treatment options is challenged by new clinical and neuroimaging data indicating that some patients with prolonged disorders of consciousness might benefit from therapeutic interventions, even years after the injury. Most studies of interventions aimed at improving patients' level of consciousness and functional recovery were behavioural and brain imaging open-label trials and case reports, but several randomised controlled trials have been done, particularly focused on the effects of drugs or use of non-invasive brain stimulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14744422193003
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http://dx.doi.org/10.1016/S1474-4422(19)30031-6DOI Listing
April 2019
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Clinical outcome of V-Y flap with latissimus dorsi and gluteal advancement for treatment of large thoracolumbar myelomeningocele defects: a comparative study.

J Neurosurg Pediatr 2019 Apr 19:1-10. Epub 2019 Apr 19.

1Department of Neurosurgery.

OBJECTIVESurgical repair and closure of myelomeningocele (MMC) defects are important and vital, as the mortality rate is as high as 65%-70% in untreated patients. Closure of large MMC defects is challenging for pediatric neurosurgeons and plastic surgeons. The aim of the current study is to report the operative characteristics and outcome of a series of Iranian patients with large MMC defects utilizing the V-Y flap and with latissimus dorsi or gluteal muscle advancement. Read More

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http://dx.doi.org/10.3171/2019.1.PEDS18232DOI Listing

Natural history of neuromodulation devices and therapies: a patient-centered survival analysis.

J Neurosurg 2019 Apr 19:1-7. Epub 2019 Apr 19.

OBJECTIVEDespite rapid development and expansion of neuromodulation technologies, knowledge about device and/or therapy durability remains limited. The aim of this study was to evaluate the long-term rate of hardware and therapeutic failure of implanted devices for several neuromodulation therapies.METHODSThe authors performed a retrospective analysis of patients' device and therapy survival data (Kaplan-Meier survival analysis) for deep brain stimulation (DBS), vagus nerve stimulation (VNS), and spinal cord stimulation (SCS) at a single institution (years 1994-2015). Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2019.2.JNS182450DOI Listing
April 2019
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GLP-1: Molecular mechanisms and outcomes of a complex signaling system.

Neurochem Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Meal ingestion provokes the release of hormones and transmitters, which in turn regulate energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01970186193009
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http://dx.doi.org/10.1016/j.neuint.2019.04.010DOI Listing
April 2019
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Transcranial Magnetic Stimulation to the Middle Frontal Gyrus During Attention Modes Induced Dynamic Module Reconfiguration in Brain Networks.

Front Neuroinform 2019 3;13:22. Epub 2019 Apr 3.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

The interaction between dorsal and ventral attention networks (VANs) is mediated by the middle frontal gyrus (MFG), which is functionally connected to both networks. However, the direct role of the MFG in selective and sustained attention remains controversial. In the current study, we used transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to probe the connectivity dynamic changes of MFG-associated regions during different attention modes. Read More

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http://dx.doi.org/10.3389/fninf.2019.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456710PMC

Abnormal Phase Coupling in Parkinson's Disease and Normalization Effects of Subthreshold Vestibular Stimulation.

Front Hum Neurosci 2019 3;13:118. Epub 2019 Apr 3.

Pacific Parkinson's Research Centre, Vancouver, BC, Canada.

The human brain is a highly dynamic structure requiring dynamic coordination between different neural systems to perform numerous cognitive and behavioral tasks. Emerging perspectives on basal ganglia (BG) and thalamic functions have highlighted their role in facilitating and mediating information transmission among cortical regions. Thus, changes in BG and thalamic structures can induce aberrant modulation of cortico-cortical interactions. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456700PMC

Long-Term Surface Electrode Impedance Recordings Associated with Gliosis for a Closed-Loop Neurostimulation Device.

Ann Neurosci 2018 Dec 14;25(4):289-298. Epub 2019 Jan 14.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Background: Closed-loop neurostimulation is a novel alternative therapy for medically intractable focal epilepsy for patients who are not candidates for surgical resection of a seizure focus. Electrodes for this system can be implanted either within the brain parenchyma or in the subdural space. The electrodes then serve the dual role of detecting seizures and delivering an electrical signal aimed at aborting seizure activity. Read More

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http://dx.doi.org/10.1159/000481805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470334PMC
December 2018

Computational model of the mechanoelectrophysiological coupling in axons with application to neuromodulation.

Phys Rev E 2019 Mar;99(3-1):032406

Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.

For more than half a century, the action potential (AP) has been considered a purely electrical phenomenon. However, experimental observations of membrane deformations occurring during APs have revealed that this process also involves mechanical features. This discovery has recently fuelled a controversy on the real nature of APs: whether they are mechanical or electrical. Read More

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https://link.aps.org/doi/10.1103/PhysRevE.99.032406
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http://dx.doi.org/10.1103/PhysRevE.99.032406DOI Listing
March 2019
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Role of inflammation in depression relapse.

J Neuroinflammation 2019 Apr 17;16(1):90. Epub 2019 Apr 17.

Department of Psychiatry, University of Connecticut Health Center, Farmington, CT, 06030, USA.

Major depressive disorder (MDD) is a leading cause of disability worldwide. After the first episode, patients with remitted MDD have a 60% chance of experiencing a second episode. Consideration of therapy continuation should be viewed in terms of the balance between the adverse effects of medication and the need to prevent a possible relapse. Read More

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http://dx.doi.org/10.1186/s12974-019-1475-7DOI Listing

Machine-learning identifies parkinson's disease patients based on resting-state between-network functional connectivity.

Br J Radiol 2019 Apr 17:20180886. Epub 2019 Apr 17.

1 Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty , Dusseldorf , Germany.

Objectives: Evaluation of a data-driven, model-based classification approach to discriminate idiopathic Parkinson's disease (PD) patients from healthy controls (HC) based on between-network connectivity in whole-brain resting-state functional MRI (rs-fMRI).

Methods: Whole-brain rs-fMRI (EPI/TR = 2.2  s/TE = 30  ms/flip angle = 90°/resolution = 3. Read More

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http://dx.doi.org/10.1259/bjr.20180886DOI Listing

Process-based framework for precise neuromodulation.

Nat Hum Behav 2019 Apr 15. Epub 2019 Apr 15.

Sagol Brain Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.

Functional MRI neurofeedback (NF) allows humans to self-modulate neural patterns in specific brain areas. This technique is regarded as a promising tool to translate neuroscientific knowledge into brain-guided psychiatric interventions. However, its clinical implementation is restricted by unstandardized methodological practices, by clinical definitions that are poorly grounded in neurobiology, and by lack of a unifying framework that dictates experimental choices. Read More

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http://www.nature.com/articles/s41562-019-0573-y
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http://dx.doi.org/10.1038/s41562-019-0573-yDOI Listing
April 2019
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Care Bundle Approach to Minimizing Infection Rates after Neurosurgical Implants for Neuromodulation: A Single Surgeon Experience.

World Neurosurg 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery, U.S. Department of Veterans Affairs Medical Center, Milwaukee, WI 53295; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226.

Introduction: Implant-related infections carry a high morbidity. Infectious rates for neuromodulation implants range from 1-9% for DBS, 0-10% for SCS systems, and 3-15% for IT pump systems. Meanwhile, studies on care bundles report infection rate reduction to 1. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.003DOI Listing

Electrical stimulation for neuroregeneration in urology: a new therapeutic paradigm.

Curr Opin Urol 2019 Apr 9. Epub 2019 Apr 9.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic.

Purpose Of Review: The present review highlights regenerative electrical stimulation (RES) as potential future treatment options for patients with nerve injuries leading to urological dysfunction, such as urinary incontinence, voiding dysfunction or erectile dysfunction. Additionally, it will highlight the mechanism of nerve injury and regeneration as well as similarities and differences between RES and current electrical stimulation treatments in urology, functional electrical stimulation (FES) and neuromodulation.

Recent Findings: It has been demonstrated that RES upregulates brain-derived neurotrophic factor (BDNF) and its receptor to facilitate neuroregeneration, facilitating accurate reinnervation of muscles by motoneurons. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000632DOI Listing
April 2019
2 Reads

Targeted Vagus Nerve Stimulation for Rehabilitation After Stroke.

Front Neurosci 2019 29;13:280. Epub 2019 Mar 29.

Texas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, United States.

Stroke is a leading cause of disability worldwide, and in approximately 60% of individuals, upper limb deficits persist 6 months after stroke. These deficits adversely affect the functional use of the upper limb and restrict participation in day to day activities. An important goal of stroke rehabilitation is to improve the quality of life by enhancing functional independence and participation in activities. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2019.00280
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http://dx.doi.org/10.3389/fnins.2019.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449801PMC
March 2019
2 Reads

Deep Brain Stimulation of the Subthalamic Nucleus Induces Impulsive Responses to Bursts of Sensory Evidence.

Front Neurosci 2019 29;13:270. Epub 2019 Mar 29.

Department of Neurosurgery, Center for Neuromodulation, NYU Langone Health, New York, NY, United States.

Decisions are made through the integration of external and internal inputs until a threshold is reached, triggering a response. The subthalamic nucleus (STN) has been implicated in adjusting the decision bound to prevent impulsivity during difficult decisions. We combine model-based and model-free approaches to test the theory that the STN raises the decision bound, a process impaired by deep brain stimulation (DBS). Read More

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http://dx.doi.org/10.3389/fnins.2019.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450191PMC
March 2019
2 Reads

Sphenopalatine Ganglion Block and Radiofrequency Ablation: Technical Notes and Efficacy.

Ochsner J 2019 ;19(1):32-37

Department of Neurosurgery, Ochsner Clinic Foundation, New Orleans, LA.

Sphenopalatine ganglion (SPG) blockade or lesioning can offer significant pain relief for cluster headaches (CHs) and a variety of other pain syndromes involving the head and face. We reviewed the literature on the efficacy of SPG block and radiofrequency ablation (RFA) using PubMed and Google Scholar. The infrazygomatic technique can be used to directly access the SPG for injection of local anesthetic or lesioning using RFA. Read More

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http://dx.doi.org/10.31486/toj.18.0163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447206PMC
January 2019

Prokinetic effects of spinal cord stimulation and its autonomic mechanisms in dogs.

Neurogastroenterol Motil 2019 Apr 14:e13596. Epub 2019 Apr 14.

Division of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, Maryland.

Background: Spinal cord stimulation (SCS) is widely used to treat chronic pain by inhibiting sympathetic activity; however, it is unknown whether it exerts a prokinetic effect on gastric motility. Our aim was to explore effects and possible mechanisms of SCS on glucagon-induced gastric dysmotility and dysrhythmia.

Methods: Seven female dogs with electrodes chronically placed on the dorsal column of the spinal cord between T10 and T12 segments were studied in 2 randomized sessions (glucagon + sham-SCS, glucagon + SCS). Read More

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http://dx.doi.org/10.1111/nmo.13596DOI Listing

The computational pharmacology of oculomotion.

Psychopharmacology (Berl) 2019 Apr 13. Epub 2019 Apr 13.

Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, WC1N 3BG, UK.

Many physiological and pathological changes in brain function manifest in eye-movement control. As such, assessment of oculomotion is an invaluable part of a clinical examination and affords a non-invasive window on several key aspects of neuronal computation. While oculomotion is often used to detect deficits of the sort associated with vascular or neoplastic events; subtler (e. Read More

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http://dx.doi.org/10.1007/s00213-019-05240-0DOI Listing

Two cases of beneficial side effects from chronic electrical stimulation for treatment of focal epilepsy.

Brain Stimul 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.03.077DOI Listing

Nongenetic optical neuromodulation with silicon-based materials.

Nat Protoc 2019 Apr 12. Epub 2019 Apr 12.

Department of Chemistry, The University of Chicago, Chicago, IL, USA.

Optically controlled nongenetic neuromodulation represents a promising approach for the fundamental study of neural circuits and the clinical treatment of neurological disorders. Among the existing material candidates that can transduce light energy into biologically relevant cues, silicon (Si) is particularly advantageous due to its highly tunable electrical and optical properties, ease of fabrication into multiple forms, ability to absorb a broad spectrum of light, and biocompatibility. This protocol describes a rational design principle for Si-based structures, general procedures for material synthesis and device fabrication, a universal method for evaluating material photoresponses, detailed illustrations of all instrumentation used, and demonstrations of optically controlled nongenetic modulation of cellular calcium dynamics, neuronal excitability, neurotransmitter release from mouse brain slices, and brain activity in the mouse brain in vivo using the aforementioned Si materials. Read More

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http://www.nature.com/articles/s41596-019-0135-9
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http://dx.doi.org/10.1038/s41596-019-0135-9DOI Listing
April 2019
4 Reads

Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects.

J Clin Med 2019 Apr 11;8(4). Epub 2019 Apr 11.

Department of Internal Medicine, Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Previous studies showed that transcutaneous vagus nerve stimulation (tVNS) modulates the autonomic nervous system (ANS) in resting condition. However, the autonomic regulation in response to an orthostatic challenge during tVNS in healthy subjects remains unknown. We tested the hypothesis that tVNS reduces heart rate (HR) and alters the responsivity of ANS to orthostatic stress in healthy subjects. Read More

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http://dx.doi.org/10.3390/jcm8040496DOI Listing
April 2019
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Extracellular mild acidosis decreases the Ca permeability of the human NMDA receptors.

Cell Calcium 2019 Apr 4;80:63-70. Epub 2019 Apr 4.

Dipartimento di Fisiologia e Farmacologia "V. Erspamer", Sapienza Università di Roma, Rome, Italy; IRCCS Neuromed, Pozzilli, Italy. Electronic address:

NMDA receptors (NMDARs) are glutamate-gated ion channels involved in excitatory synaptic transmission and in others physiological processes such as synaptic plasticity and development. The overload of Ca ions through NMDARs, caused by an excessive activation of receptors, leads to excitotoxic neuronal cell death. For this reason, the reduction of Ca flux through NMDARs has been a central focus in finding therapeutic strategies to prevent neuronal cell damage. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.04.001DOI Listing
April 2019
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Commentary on: Sacral neuromodulation treating chronic pelvic pain: a meta-analysis and systematic review of the literature.

Authors:
Rachel High

Int Urogynecol J 2019 Apr 11. Epub 2019 Apr 11.

Baylor Scott & White Health, Temple, TX, USA.

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http://dx.doi.org/10.1007/s00192-019-03927-8DOI Listing
April 2019
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Psychiatric Neurosurgery: A Survey on the Perceptions of Psychiatrists and Residents.

Can J Neurol Sci 2019 Apr 12:1-8. Epub 2019 Apr 12.

Department of Psychiatry, McGill University Health Center,McGill University,Montreal, Quebec,Canada.

Objectives: To evaluate the attitudes and perceptions of psychiatrists and psychiatry residents regarding neurosurgical procedures for treating psychiatric disorders and to identify potential barriers to patient referral.

Methods: A survey consisting of 25 questions was created using SurveyMonkey and was distributed to psychiatrists and psychiatry residents in Quebec. The study was approved by the McGill University Health Center's Research Ethics Board. Read More

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http://dx.doi.org/10.1017/cjn.2019.5DOI Listing
April 2019
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Burst and Tonic Spinal Cord Stimulation in the Mechanical Conflict-Avoidance System: Cognitive-Motivational Aspects.

Neuromodulation 2019 Apr 11. Epub 2019 Apr 11.

Department of Anesthesiology and Pain Management, MUMC, Pain Management and Research Centre, Maastricht, The Netherlands.

Background: Clinical research suggests that a novel spinal cord stimulation (SCS) waveform, known as Burst-SCS, specifically targets cognitive-motivational aspects of pain. The objective of the present study was to assess the cognitive-motivational aspects of Tonic- and Burst SCS-induced pain relief, by means of exit latency in the mechanical conflict-avoidance system (MCAS), in a rat model of chronic neuropathic pain.

Methods: Exit latency on the MCAS operant testing setup was evaluated at various probe heights for rats (n = 26) with chronic neuropathic pain induced by a partial sciatic nerve ligation (PSNL). Read More

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http://dx.doi.org/10.1111/ner.12955DOI Listing

Magnetic Resonance Imaging Exploration of the Human Brain During 10 kHz Spinal Cord Stimulation for Failed Back Surgery Syndrome: A Resting State Functional Magnetic Resonance Imaging Study.

Neuromodulation 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurosurgery, Universitair Ziekenhuis Brussel, Brussels, Belgium.

Introduction: Apart from the clinical efficacy of high frequency spinal cord stimulation at 10 kHz, the underlying mechanism of action remains unclear. In parallel with spinal or segmental theories, supraspinal hypotheses have been recently proposed. In order to unveil hidden altered brain connectome patterns, a resting state functional magnetic resonance imaging (rsfMRI) protocol was performed in subjects routinely treated for back and/or leg pain with high-frequency spinal cord stimulation (HF-SCS) HF-SCS at 10 kHz. Read More

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http://dx.doi.org/10.1111/ner.12954DOI Listing
April 2019
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1.785 Impact Factor

Neuromuscular dentistry and the role of the autonomic nervous system: Sphenopalatine ganglion blocks and neuromodulation. An International College of Cranio Mandibular Orthopedics (ICCMO) position paper.

Authors:
Ira L Shapira

Cranio 2019 May;37(3):201-206

a Regent, Master & Fellow , International College of Cranio Mandibular Orthopedics (ICCMO), Private Practice, Delany Dental Care, Gurnee, IL and Think Better Life , Highland Park , IL , USA.

The Sphenopalatine Ganglion (SPG) is known to play an integral role in the pathophysiology of a wide variety of orofacial pains involving the jaws, sinuses, eyes and the trigeminal autonomic cephalalgias. It supplies direct parasympathetic innervation to the trigeminal and facial nerves. Sympathetic innervation from the superior sympathetic chain passes thru the SPG to the trigeminal and facial nerves. Read More

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http://dx.doi.org/10.1080/08869634.2019.1592807DOI Listing

Percutaneous tibial nerve stimulation (PTNS): an alternative treatment option for chronic therapy resistant anal fissure.

Tech Coloproctol 2019 Apr 10. Epub 2019 Apr 10.

Department of Surgery, Pelvic Floor Centre, Skåne University Hospital-SUS, Lund University, 205 02, Malmö, Sweden.

Background: The aim of the present study was to evaluate percutaneous tibial nerve stimulation (PTNS) for treatment resistant chronic anal fissure.

Methods: Consecutive patients with chronic anal fissure were treated with neuromodulation via the posterior tibial nerve between October 2013 and January 2014. Patients had PTNS for 30 min on 10 consecutive days. Read More

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http://dx.doi.org/10.1007/s10151-019-01972-5DOI Listing
April 2019
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Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study.

Front Neurol 2019 26;10:279. Epub 2019 Mar 26.

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.

This study presents the first implementation of functional ultrasound (fUS) imaging of the spinal cord to monitor local hemodynamic response to epidural electrical spinal cord stimulation (SCS) on two small and large animal models. SCS has been successfully applied to control chronic refractory pain and recently was evolved to alleviate motor impairment in Parkinson's disease and after spinal cord injury. At present, however, the mechanisms underlying SCS remain unclear, and current methods for monitoring SCS are limited in their capacity to provide the required sensitivity and spatiotemporal resolutions to evaluate functional changes in response to SCS. Read More

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http://dx.doi.org/10.3389/fneur.2019.00279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445046PMC

Amygdala Modulation During Emotion Regulation Training With fMRI-Based Neurofeedback.

Front Hum Neurosci 2019 26;13:89. Epub 2019 Mar 26.

CIBIT, ICNAS-Institute of Nuclear Sciences Applied to Health-and CNC.IBILI-Faculty of Medicine, Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Azinhaga de Santa Comba, Coimbra, Portugal.

Available evidence suggests that individuals can enhance their ability to modulate brain activity in target regions, within the Emotion Regulation network, using fMRI-based neurofeedback. However, there is no systematic review that investigates the effectiveness of this method on amygdala modulation, a core region within this network. The major goal of this study was to systematically review and analyze the effects of real-time fMRI-Neurofeedback concerning the neuromodulation of the amygdala during Emotion Regulation training. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444080PMC
March 2019
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NPY Receptors Reduce Tonic Action Potential-Independent GABA Currents in the Basolateral Amygdala.

J Neurosci 2019 Apr 10. Epub 2019 Apr 10.

Department of Pharmacology, University of Alberta, Edmonton Alberta, Canada, T6G 2H7

Although neuropeptide Y (NPY) has potent anxiolytic actions within the basolateral amygdala (BLA), selective activation of BLA NPY Y receptors (YR) acutely increases anxiety by an unknown mechanism. Using male rat brain slice electrophysiology, we show that the selective YR agonist, [ahx]NPY, reduced the frequency of GABA-mediated miniature inhibitory post synaptic currents (mIPSC) in BLA principal neurons (PN). [ahx]NPY also reduced tonic activation of GABA receptors (GABAR), which increased PN excitability through inhibition of a tonic, inwardly-rectifying potassium current ( ). Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2226-1
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http://dx.doi.org/10.1523/JNEUROSCI.2226-18.2019DOI Listing
April 2019
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Safety of transcranial direct current stimulation in a patient with deep brain stimulation electrodes.

Arq Neuropsiquiatr 2019 Mar;77(3):174-178

Universidade de Brasília, Departamento de Ciências Fisiológicas, Instituto de Biologia, Brasília DF, Brasil.

Background: Transcranial direct current stimulation (tDCS) has been investigated in movement disorders, making it a therapeutic alternative in clinical settings. However, there is still no consensus on the most appropriate treatment protocols in most cases, and the presence of deep brain stimulation (DBS) electrodes has been regarded as a contraindication to the procedure. We recently studied the effects of cerebellar tDCS on a female patient already undergoing subthalamic nucleus deep brain stimulation (STN-DBS) for generalized dystonia. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/0004-282X20190019DOI Listing
March 2019
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Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands.

Methods Mol Biol 2019 ;1947:103-136

Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA.

G protein-coupled receptors (GPCRs) respond to a wide range of extracellular cues to initiate complex downstream signaling cascades that control myriad aspects of cell function. Despite a long-standing appreciation of their importance to both basic physiology and disease treatment, it remains a major challenge to understand the dynamic activation patterns of GPCRs and the mechanisms by which they modulate biological processes at the molecular, cellular, and tissue levels. Unfortunately, classical methods of pharmacology and genetic knockout are often unable to provide the requisite precision needed to probe such questions. Read More

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http://link.springer.com/10.1007/978-1-4939-9121-1_6
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http://dx.doi.org/10.1007/978-1-4939-9121-1_6DOI Listing
January 2019
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Photobiomodulation-induced analgesia in experimental temporomandibular disorder involves central inhibition of fractalkine.

Lasers Med Sci 2019 Apr 10. Epub 2019 Apr 10.

Laboratory of Neuromodulation of Experimental Pain, Department of Anatomy, Insitute of Biomedical Sciences, University of São Paulo, Av. Professor Lineu Prestes 2415, ICB III, Cidade Universitária, Sao Paulo, 05508-900, Brazil.

Temporomandibular disorder (TMD) is a collective term that encompasses a set of clinical problems that affect the masticatory muscles, the temporomandibular joint, and associated structures. Despite their high clinical prevalence, the mechanisms of chronic craniofacial muscle pain are not yet well understood. Treatments for TMD pain relief and control should be minimally invasive, reversible, and conservative. Read More

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http://dx.doi.org/10.1007/s10103-019-02785-6DOI Listing
April 2019
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Binding and transport of D-aspartate by the glutamate transporter homolog Glt.

Elife 2019 Apr 10;8. Epub 2019 Apr 10.

Groningen Biomolecular Sciences and Biotechnology Institute, Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.

Mammalian glutamate transporters are crucial players in neuronal communication as they perform neurotransmitter reuptake from the synaptic cleft. Besides L-glutamate and L-aspartate, they also recognize D-aspartate, which might participate in mammalian neurotransmission and/or neuromodulation. Much of the mechanistic insight in glutamate transport comes from studies of the archeal homologs Glt from and Glt from . Read More

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https://elifesciences.org/articles/45286
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http://dx.doi.org/10.7554/eLife.45286DOI Listing
April 2019
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Gamma tACS over the temporal lobe increases the occurrence of Eureka! moments.

Sci Rep 2019 Apr 8;9(1):5778. Epub 2019 Apr 8.

Brain Investigation & Neuromodulation Laboratory (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Siena, Italy.

The solution to a problem might manifest itself as a burst of unexpected, unpredictable clarity. Such Eureka! events, or Insight moments, are among the most fascinating mysteries of human cognition, whose neurophysiological substrate seems to include a role for oscillatory activity within the α and γ bands in the right parietal and temporal brain regions. We tested this hypothesis on thirty-one healthy participants using transcranial Alternating Current Stimulation (tACS) to externally amplify α (10 Hz) and γ (40 Hz) activity in the right parietal and temporal lobes, respectively. Read More

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http://dx.doi.org/10.1038/s41598-019-42192-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453961PMC

Childhood trauma history is linked to abnormal brain connectivity in major depression.

Proc Natl Acad Sci U S A 2019 Apr 8;116(17):8582-8590. Epub 2019 Apr 8.

Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

Patients with major depressive disorder (MDD) present with heterogeneous symptom profiles, while neurobiological mechanisms are still largely unknown. Brain network studies consistently report disruptions of resting-state networks (RSNs) in patients with MDD, including hypoconnectivity in the frontoparietal network (FPN), hyperconnectivity in the default mode network (DMN), and increased connection between the DMN and FPN. Using a large, multisite fMRI dataset ( = 189 patients with MDD, = 39 controls), we investigated network connectivity differences within and between RSNs in patients with MDD and healthy controls. Read More

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http://dx.doi.org/10.1073/pnas.1900801116DOI Listing
April 2019
8 Reads