8,989 results match your criteria Neuromodulation: Technology at the Neural Interface [Journal]


Chronic electrical stimulation reduces hyperalgesia and associated spinal changes induced by peripheral nerve injury.

Neuromodulation 2019 Feb 20. Epub 2019 Feb 20.

Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autònoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, Spain.

Objectives: We aimed to investigate if different protocols of electrical stimulation following nerve injury might improve neuropathic pain outcomes and modify associated plastic changes at the spinal cord level.

Materials And Methods: Adult rats were subjected to sciatic nerve transection and repair, and distributed in four groups: untreated (SNTR, n = 12), repeated acute electrical stimulation (rAES, 50 Hz, one hour, n = 12), chronic electrical stimulation (CES, 50 Hz, one hour, n = 12), and increasing-frequency chronic electrical stimulation (iCES, one hour, n = 12) delivered during two weeks following the lesion. The threshold of nociceptive withdrawal to mechanical stimuli was evaluated by means of a Von Frey algesimeter during three weeks postlesion. Read More

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http://dx.doi.org/10.1111/ner.12927DOI Listing
February 2019

Suppression of Urinary Voiding "on Demand" by High-Frequency Stimulation of the S1 Sacral Nerve Root in Anesthetized Rats.

Neuromodulation 2019 Feb 20. Epub 2019 Feb 20.

Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.

Objectives: High-frequency (kHz) stimulation of preganglionic pelvic nerve afferents can inhibit voiding in both anesthetized and conscious rats. The afferents travel via the S1 sacral nerve root, which is easier to access than the distal pelvic nerve fibers within the abdominal cavity. We therefore investigated whether voiding could be inhibited by high-frequency stimulation at S1 and how this compared to distal pelvic nerve stimulation. Read More

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http://dx.doi.org/10.1111/ner.12928DOI Listing
February 2019

Evaluation Through Transcutaneous Tissue Oximetry (Near Infrared Spectroscopy) of Spinal Cord Stimulation in Patients With Complex Regional Pain Syndrome Type I.

Neuromodulation 2019 Feb 20. Epub 2019 Feb 20.

Pain Unit, Anesthesiology and Resuscitation Department, University Care Complex of Salamanca (Complejo Asistencial Universitario de Salamanca), Salamanca, Spain.

Objective: One of the physiopathological hypothesis behind complex regional pain syndrome (CRPS) type I involves the deep-tissue hypoxia of the affected areas. Spinal cord stimulation (SCS) appears to be effective in the treatment of these patients. We evaluated whether ESCS modifies tissue oxygen saturation (StO ) measured with near-infrared spectroscopy (NIRS) in the affected limbs in patients diagnosed with CRPS type I. Read More

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http://dx.doi.org/10.1111/ner.12931DOI Listing
February 2019

Spontaneous Ascending Migration of a Paddle Lead.

Neuromodulation 2019 Feb 20. Epub 2019 Feb 20.

Neurosurgery Department, Hospital Universitario La Paz, Madrid, Spain.

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http://dx.doi.org/10.1111/ner.12933DOI Listing
February 2019

A double-blind pilot dosing study of low field magnetic stimulation (LFMS) for treatment-resistant depression (TRD).

J Affect Disord 2019 Feb 14;249:286-293. Epub 2019 Feb 14.

Department of Psychiatry, Weill Cornell Medical College-New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10065, USA; Institute of Geriatric Psychiatry, Weill Cornell Medical College-New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10065, USA.

Background: Low field magnetic stimulation is a potentially rapid-acting treatment for depression with mood-enhancing effects in as little as one 20-min session. The most convincing data for LFMS has come from treating bipolar depression. We examined whether LFMS also has rapid mood-enhancing effects in treatment-resistant major depressive disorder, and whether these effects are dose-dependent. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.039DOI Listing
February 2019

AAV-Mediated Gene Delivery to the Enteric Nervous System by Intracolonic Injection.

Methods Mol Biol 2019 ;1950:407-415

Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.

The enteric nervous system of the lower gastrointestinal tract comprises intrinsic neural circuits as well as extrinsic afferent and efferent innervation. The development of strategies for neuronal gene transfer has created new opportunities for functional analysis, circuit mapping, and neuromodulation in the enteric nervous system. Studies of AAV-mediated gene transfer to enteric neurons and dorsal root ganglion neurons (DRG) have provided proofs-of-concept for the utility of AAV vectors for genetic manipulations of the intrinsic and extrinsic components of the enteric nervous system. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_24DOI Listing
January 2019

Percutaneous Neurolysis for Pain Management in Oncological Patients.

Cardiovasc Intervent Radiol 2019 Feb 19. Epub 2019 Feb 19.

Division of Interventional Radiology, Department of Radiology, University Hospital Waterford, Ardkeen, Waterford City, Ireland.

Cancer pain is most commonly classified as nociceptive (somatic or visceral) or neuropathic. Different types of pain or pain syndromes are present in all phases of cancer (early and metastatic) and are inadequately treated in 56% to 82.3% of patients. Read More

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http://dx.doi.org/10.1007/s00270-019-02185-xDOI Listing
February 2019

A wave of the WAND for neuromodulation.

Authors:
Jim Kling

Lab Anim (NY) 2019 Mar;48(3):85

Freelance writer, Bellingham, Washington, USA.

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http://dx.doi.org/10.1038/s41684-019-0250-9DOI Listing

Optogenetic stimulation of the M2 cortex reverts motor dysfunction in a mouse model of Parkinson's Disease.

J Neurosci 2019 Feb 19. Epub 2019 Feb 19.

Centro de Tecnologia em Medicina Molecular

Neuromodulation of deep brain structures (deep brain stimulation - DBS) is the current surgical procedure for treatment of Parkinson's disease. Less studied is the stimulation of cortical motor areas to treat PD symptoms, although also known to alleviate motor disturbances in PD. We were able to show that optogenetic activation of secondary (M2) motor cortex improves motor functions in dopamine-depleted male mice. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2277-18.2019DOI Listing
February 2019

Impact of a specific training programme on the neuromodulation of pain in female patient with fibromyalgia (DouFiSport): a 24-month, controlled, randomised, double-blind protocol.

BMJ Open 2019 Jan 25;9(1):e023742. Epub 2019 Jan 25.

LIEN, EA4685, University of Western Brittany (UBO), Brest, France.

Introduction: The main symptom of fibromyalgia (FM) is diffuse pain. There is currently no aetiological treatment for FM. However, all pain associations and best practice guidelines strongly advocate the practice of aerobic physical activity to improve the symptoms of FM subjects. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023742DOI Listing
January 2019

Low-intensity pulsed ultrasound modulates multi-frequency band phase synchronization between LFPs and EMG in mice.

J Neural Eng 2019 Feb 19. Epub 2019 Feb 19.

1Institute of Electrical Engineering, Yanshan University, Qinhuangdao, CHINA.

Objective: Low-intensity pulsed ultrasound stimulation (LIPUS) targeted to the mouse motor cortex can simultaneously induce local field potentials (LFPs) and electromyogram (EMG) responses. However, the functional coupling relationship between LFP and EMG signals has not been elucidated to date. This study aimed to investigate the phase synchronization between LFP and EMG signals induced by LIPUS over the mouse motor cortex. Read More

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http://dx.doi.org/10.1088/1741-2552/ab0879DOI Listing
February 2019

Does outpatient palliative care improve patient-centered outcomes in Parkinson's disease: Rationale, design, and implementation of a pragmatic comparative effectiveness trial.

Contemp Clin Trials 2019 Feb 16. Epub 2019 Feb 16.

Division of Neurology, University of Alberta, 11350-83 Avenue, 7-112 Clinical Sciences Building, Edmonton, AB T6G 2G3, Canada. Electronic address:

Patients with Parkinson's disease and related disorders (PDRD) and their families have considerable unmet needs including non-motor symptom management, caregiver support, spiritual wellbeing, advance care planning, and end-of-life care. There is increasing interest in applying palliative care (PC) models to better meet these needs. While PC has been shown to improve care and quality of life (QOL) for people with cancer and heart failure, few studies have evaluated the role of PC for people with PDRD. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.005DOI Listing
February 2019
1 Read

Combining rTMS With Intensive Language-Action Therapy in Chronic Aphasia: A Randomized Controlled Trial.

Front Neurosci 2018 4;12:1036. Epub 2019 Feb 4.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient (ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013; Martin et al. Read More

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http://dx.doi.org/10.3389/fnins.2018.01036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369187PMC
February 2019

Where does the balance lie between doing what's right for our patients and patients' rights? Spinal cord stimulation in chronic pain smokers.

Authors:
Nagy Mekhail

Reg Anesth Pain Med 2019 Mar;44(3):421-422

Evidence-Based Pain Management Department, Cleveland Clinic, Cleveland, Ohio, USA

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http://dx.doi.org/10.1136/rapm-2018-100321DOI Listing

Connectivity Profile Predictive of Effective Deep Brain Stimulation in Obsessive-Compulsive Disorder.

Biol Psychiatry 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany; Department of Psychiatry and Psychotherapy, Johanniter Hospital Oberhausen, Oberhausen, Germany.

Background: Deep brain stimulation for obsessive-compulsive disorder is a rapidly developing treatment strategy for treatment-refractory patients. Both the exact target and impact on distributed brain networks remain a matter of debate. Here, we investigated which regions connected to stimulation sites contribute to clinical improvement effects and whether connectivity is able to predict outcomes. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.019DOI Listing
January 2019

Parsing the Hippocampus in Depression: Chronic Stress, Hippocampal Volume, and Major Depressive Disorder.

Biol Psychiatry 2019 Mar;85(6):436-438

Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, the Rockefeller University, New York, New York.

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http://dx.doi.org/10.1016/j.biopsych.2019.01.011DOI Listing

IL-17c is involved in olfactory mucosa responses to Poly(I:C) mimicking virus presence.

Brain Behav Immun 2019 Feb 15. Epub 2019 Feb 15.

NBO, INRA, Univ Paris-Saclay, 78350 Jouy-en-Josas, France; Université de Versailles Saint-Quentin en Yvelines, 78000 Versailles, France. Electronic address:

At the interface of the environment and the nervous system, the olfactory mucosa (OM) is a privileged pathway for environmental toxicants and pathogens towards the central nervous system. The OM is known to produce antimicrobial and immunological components but the mechanisms of action of the immune system on the OM remain poorly explored. IL-17c is a potent mediator of respiratory epithelial innate immune responses, whose receptors are highly expressed in the OM of mice. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.012DOI Listing
February 2019

A Driving-Force Predictor for Estimating Pathway Activation in Patient-Specific Models of Deep Brain Stimulation.

Neuromodulation 2019 Feb 18. Epub 2019 Feb 18.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Objective: Detailed biophysical modeling of deep brain stimulation (DBS) provides a theoretical approach to quantify the cellular response to the applied electric field. However, the most accurate models for performing such analyses, patient-specific field-cable (FC) pathway-activation models (PAMs), are so technically demanding to implement that their use in clinical research is greatly limited. Predictive algorithms can simplify PAM calculations, but they generally fail to reproduce the output of FC models when evaluated over a wide range of clinically relevant stimulation parameters. Read More

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http://dx.doi.org/10.1111/ner.12929DOI Listing
February 2019

The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 25;5(1):41-48. Epub 2018 Sep 25.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.

Objectives: Obstructive sleep apnea (OSA) is a prevalent disease with significant health impacts. While first line therapy is CPAP, long-term compliance is low and device misuse is common, highlighting the need for alternative therapies. Upper airway surgery is one alternative, but substantial side effects hamper efficacy. Read More

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http://dx.doi.org/10.1016/j.wjorl.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364516PMC

The paraventricular thalamic nucleus: A key hub of neural circuits underlying drug addiction.

Pharmacol Res 2019 Feb 14;142:70-76. Epub 2019 Feb 14.

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. Electronic address:

Drug addiction is a chronic relapsing brain disease characterized by compulsive, out-of-control drug use and the appearance of negative somatic and emotional consequences when drug access is prevented. The limited efficacy of treatment urges researchers toward a deeper understanding of the neural mechanism of drug addiction. Brain circuits that regulate reward and motivation are considered to be the neural substrate of drug addiction. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.014DOI Listing
February 2019

Development of evidence-based quality indicators for deep brain stimulation in patients with Parkinson's disease and first year experience of implementation of a nation-wide registry.

Parkinsonism Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany; Comprehensive Heart Failure Center, University Würzburg, Clincial Trial Center Würzburg, University Hospital Würzburg, Germany.

Introduction: Deep Brain Stimulation (DBS) is a complex, invasive and cost-intensive therapy that requires a high level of expertise. To date, data on quality of DBS in clinical routine in the German health care system are lacking.

Methods: The development of evidence-based QIs for DBS in PD patients was performed following a standardized process by a multidisciplinary board between 2014 and 2016. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.016DOI Listing
February 2019

Ultrasound-guided percutaneous peripheral nerve stimulation: neuromodulation of the suprascapular nerve and brachial plexus for postoperative analgesia following ambulatory rotator cuff repair. A proof-of-concept study.

Reg Anesth Pain Med 2019 Feb 15. Epub 2019 Feb 15.

Departments of Orthopaedic Surgery, University of California San Diego, San Diego, California, USA.

Background And Objectives: Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through an introducing needle followed by the delivery of electric current. This modality has been reported to treat chronic pain as well as postoperative pain following knee and foot surgery. However, it remains unknown if this analgesic technique may be used in ambulatory patients following upper extremity surgery. Read More

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http://dx.doi.org/10.1136/rapm-2018-100121DOI Listing
February 2019
11 Reads

Double-Blind, Sham-Controlled, Pilot Study of Trigeminal Nerve Stimulation for ADHD.

J Am Acad Child Adolesc Psychiatry 2019 Jan 28. Epub 2019 Jan 28.

Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at UCLA, Los Angeles, CA.

Objective: Trigeminal nerve stimulation (TNS), a minimal risk, non-invasive neuromodulation method, has showed potential benefits for attention-deficit/hyperactivity disorder (ADHD) in an unblinded open study. This blinded sham-controlled trial was conducted to assess efficacy and safety of TNS for ADHD, as well as potential changes in brain spectral power using resting-state quantitative electroencephalography (qEEG).

Method: 62 children aged 8-12 years, with full-scale IQ ≥ 85 and KSADS-diagnosed ADHD, were randomized to four weeks nightly treatment with active or sham TNS, followed by one-week without intervention. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193004
Publisher Site
http://dx.doi.org/10.1016/j.jaac.2018.11.013DOI Listing
January 2019
5 Reads

Shorter pulse width reduces gait disturbances following deep brain stimulation for essential tremor.

J Neurol Neurosurg Psychiatry 2019 Feb 14. Epub 2019 Feb 14.

Charité - Universitätsmedizin Berlin, Department of Neurology, Movement Disorder and Neuromodulation Unit, Berlin, Germany

Objective: Gait disturbances are frequent side effects occurring during chronic thalamic deep brain stimulation (DBS) in patients with essential tremor (ET). Adapting stimulation settings to shorter pulse widths has been shown to reduce side effects of subthalamic DBS. Here, we assess how a reduction of pulse width changes gait performance of affected patients. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319427DOI Listing
February 2019

The effect of dopamine on response inhibition in Parkinson's disease relates to age-dependent patterns of nigrostriatal degeneration.

Parkinsonism Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

Charité - Universitätsmedizin Berlin, Movement Disorders and Neuromodulation Unit, Department of Neurology, Campus Virchow Klinikum and Campus Mitte, Charitéplatz 1, 10119, Berlin, Germany. Electronic address:

Introduction: Motor but also non-motor effects are modulated by dopamine (DA) in Parkinson's disease (PD). Impaired inhibition has been related to dopamine overdosing of the associative striatum. We compared effects of dopaminergic medication on inhibitory control in patients with young (age at onset <50 years, YOPD) and late onset PD (LOPD) and related them to nigrostriatal degeneration. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.003DOI Listing
February 2019
1 Read

Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation.

Neuron 2019 Feb 7. Epub 2019 Feb 7.

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Electronic address:

The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas of the primate brain. Here, we demonstrate that a focused transcranial ultrasound stimulation (TUS) protocol impacts activity even in deep brain areas: a subcortical brain structure, the amygdala (experiment 1), and a deep cortical region, the anterior cingulate cortex (ACC, experiment 2), in macaques. Read More

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http://dx.doi.org/10.1016/j.neuron.2019.01.019DOI Listing
February 2019

Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study.

Am J Psychiatry 2019 Feb 15:appiajp201818091096. Epub 2019 Feb 15.

The Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto (Kaster, Knyahnytska, Daskalakis, Blumberger); the Department of Psychiatry (Kaster, Downar, Giacobbe, Kennedy, Daskalakis, Blumberger), the Institute of Medical Science (Downar, Giacobbe, Kennedy, Daskalakis, Blumberger), and the Dalla Lana School of Public Health (Thorpe), University of Toronto, Toronto; the MRI-Guided rTMS Clinic, Toronto Western Hospital, Toronto (Downar); the Krembil Research Institute, University Health Network, Toronto (Downar, Kennedy); the Department of Psychiatry, University of British Columbia, Vancouver (Vila-Rodriguez, Lam); the Non-Invasive Neurostimulation Therapies Laboratory, University of British Columbia, Vancouver (Vila-Rodriguez); the Shalvata Mental Health Center, Hod-Hasharon, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv (Feffer); the Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo (Noda); the Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto (Giacobbe); and the Li Ka Shing Knowledge Institute, Saint Michael's Hospital, Toronto (Kennedy).

Objective:: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for refractory major depressive disorder, yet no studies have characterized trajectories of rTMS response. The aim of this study was to characterize response trajectories for patients with major depression undergoing left dorsolateral prefrontal cortex rTMS and to determine associated baseline clinical characteristics.

Methods:: This was a secondary analysis of a randomized noninferiority trial (N=388) comparing conventional 10-Hz rTMS and intermittent theta burst stimulation (iTBS) rTMS. Read More

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18
Publisher Site
http://dx.doi.org/10.1176/appi.ajp.2018.18091096DOI Listing
February 2019
5 Reads

Dorsal Root Ganglion Stimulation as a Potentially Effective Treatment for Painful Hereditary and Idiopathic Axonal Polyneuropathy: A Retrospective Case Series.

Neuromodulation 2019 Feb 14. Epub 2019 Feb 14.

Department of Anesthesiology, Pain Medicine, University of Florida, Gainesville, FL, USA.

Objectives: Dorsal root ganglion (DRG) stimulation has been demonstrated to be effective in treating painful diabetic polyneuropathy in a small case series. However, diabetic polyneuropathy only accounts for 41% of all polyneuropathies and the efficacy of DRG on other types of polyneuropathy is unclear. The objective of this study is to evaluate the efficacy of DRG stimulation in treating painful hereditary and idiopathic axonal polyneuropathy. Read More

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http://dx.doi.org/10.1111/ner.12924DOI Listing
February 2019

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Nature 2019 Feb 13;566(7744):388-392. Epub 2019 Feb 13.

Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.

Microglia have critical roles not only in neural development and homeostasis, but also in neurodegenerative and neuroinflammatory diseases of the central nervous system. These highly diverse and specialized functions may be executed by subsets of microglia that already exist in situ, or by specific subsets of microglia that develop from a homogeneous pool of cells on demand. However, little is known about the presence of spatially and temporally restricted subclasses of microglia in the central nervous system during development or disease. Read More

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http://www.nature.com/articles/s41586-019-0924-x
Publisher Site
http://dx.doi.org/10.1038/s41586-019-0924-xDOI Listing
February 2019
4 Reads

Methylation of cation-chloride cotransporters NKCC1 and KCC2 in patients with juvenile myoclonic epilepsy.

Neurol Sci 2019 Feb 13. Epub 2019 Feb 13.

Faculty of Medicine Department of Neurology and Clinical Neurophysiology, Muğla Sıtkı Koçman University, Muğla, Turkey.

The etiology of juvenile myoclonic epilepsy (JME) is still unknown and the process of elaboration of multiple genetic mechanisms is ongoing. The aim of this study was to investigate the potential role of NKCC1 (SCL12A2) and KCC2 (SCL12A5) in JME by comparing their DNA methylation status in patients with JME versus healthy controls. Forty-nine patients with JME and 39 healthy individuals were compared for DNA methylation at the 5CpG islands. Read More

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http://dx.doi.org/10.1007/s10072-019-03743-4DOI Listing
February 2019

Response to "Spinal Cord Stimulation-The Implantable Systems Performance Registry".

Neuromodulation 2019 Feb;22(2):231

Department of Neurosciences, Research Group Experimental Neurosurgery and Neuroanatomy, KU Leuven - University, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1111/ner.12935DOI Listing
February 2019

Assessment of Clinical Meaningfulness of Endpoints in the Generation Program by the Insights to Model Alzheimer's Progression in Real Life (iMAP) Study.

J Prev Alzheimers Dis 2019 ;6(2):85-89

Ana Graf, Senior Global Program Head, Novartis Pharma AG, Fabrikstrasse 12-4.03.35A, CH-4002 Basel, Switzerland, E-mail:

We are launching the Insights to Model Alzheimer's Progression in Real Life study in parallel with the Alzheimer Prevention Initiative Generation Program. This is a 5-year, multinational, prospective, longitudinal, non-interventional cohort study that will collect data across the spectrum of Alzheimer's disease. The primary objective is to assess the ability of the Alzheimer's Prevention Initiative Cognitive Composite Test Score and Repeatable Battery for the Assessment of Neuropsychological Status to predict clinically meaningful outcomes such as diagnosis of mild cognitive impairment or dementia due to Alzheimer's disease, and change in Clinical Dementia Rating - Global Score. Read More

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http://dx.doi.org/10.14283/jpad.2018.49DOI Listing
January 2019
1 Read

Medical Methods Patents in Neuromodulation.

Neuromodulation 2019 Feb 12. Epub 2019 Feb 12.

Department of Clinical Neurosciences and Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

There is a rapidly growing number of patents on methods of modulating brain regions. Despite this trend, and the massive potential of neuromodulation for treating patients, researchers and physicians who use neuromodulation techniques and technologies often have little idea of the significant ways these patents could affect their work. This article describes medical method patents, including a brief history of their development, and analyzes their potential direct and indirect effects on neuromodulation treatment and research efforts. Read More

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http://dx.doi.org/10.1111/ner.12919DOI Listing
February 2019

Alternate Subthalamic Nucleus Deep Brain Stimulation Parameters to Manage Motor Symptoms of Parkinson's Disease: Systematic Review and Meta-analysis.

Mov Disord Clin Pract 2019 Jan 8;6(1):17-26. Epub 2018 Nov 8.

School of Behavioural and Health Sciences Australian Catholic University Brisbane Queensland Australia.

Background: The use of alternate frequencies, amplitudes, and pulse widths to manage motor symptoms in Parkinson's disease (PD) patients with subthalamic nucleus deep brain stimulation (STN-DBS) is of clinical interest, but currently lacks systematic evidence.

Objective/hypothesis: Systematically review whether alternate STN-DBS settings influence the therapy's efficacy for managing PD motor symptoms.

Methods: Systematic searches identified studies that; involved bilateral STN-DBS PD patients; manipulated ≥ 1 STN-DBS parameter (e. Read More

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http://dx.doi.org/10.1002/mdc3.12681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335519PMC
January 2019
1 Read

Noninvasive brain stimulation in obsessive-compulsive disorder.

Indian J Psychiatry 2019 Jan;61(Suppl 1):S66-S76

Department of Psychiatry, WISER Neuromodulation Program, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Obsessive-compulsive disorder (OCD) is a complex neuropsychiatric disorder with a chronic course, contributing to significant socio-occupational dysfunction. Forty percent of patients remain treatment refractive despite mainstream treatment options such as serotonin-reuptake inhibitors and cognitive behavior therapy. Noninvasive brain stimulation approaches such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have piqued interest as add-on treatment options in OCD. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_522_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343411PMC
January 2019
1 Read

Indian guidelines on neurosurgical interventions in psychiatric disorders.

Indian J Psychiatry 2019 Jan-Feb;61(1):13-21

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Neurosurgery for psychiatric disorders (NPD) has been practiced for >80 years. However, the interests have waxed and waned, from 1000s of surgeries in 1940-1950s to handful of surgery in 60-80s. This changed with the application of deep brain stimulation surgery, a surgery, considered to be "reversible" there has been a resurgence in interest. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_536_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341921PMC
February 2019
1 Read

Optogenetic Control of the Peripheral Nervous System.

Authors:
Rui B Chang

Cold Spring Harb Perspect Med 2019 Feb 11. Epub 2019 Feb 11.

Department of Neuroscience, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520.

The peripheral nervous system (PNS) is highly complicated and heterogenous. Conventional neuromodulatory approaches have revealed numerous essential biological functions of the PNS and provided excellent tools to treat a large variety of human diseases. Yet growing evidence indicated the importance of cell-type-specific neuromodulation in the PNS in not only biological research using animal models but also potential human therapies. Read More

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http://dx.doi.org/10.1101/cshperspect.a034397DOI Listing
February 2019

Restoring Movement in Paralysis with a Bioelectronic Neural Bypass Approach: Current State and Future Directions.

Authors:
Chad E Bouton

Cold Spring Harb Perspect Med 2019 Feb 11. Epub 2019 Feb 11.

Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York 11030.

Bioelectronic medicine is a rapidly growing field that explores targeted neuromodulation in new treatment options addressing both disease and injury. New bioelectronic methods are being developed to monitor and modulate neural activity directly. The therapeutic benefit of these approaches has been validated in recent clinical studies in various conditions, including paralysis. Read More

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http://dx.doi.org/10.1101/cshperspect.a034306DOI Listing
February 2019

Light at the end of the tunnel: Improvement of post-stroke visual field defect after open-label navigated perilesional rTMS.

Brain Stimul 2019 Jan 31. Epub 2019 Jan 31.

Ain Shams Neuromodulation Research Lab, Neurology dep, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.01.018DOI Listing
January 2019

Effects of High- and Low-Frequency Stimulation of the Thalamic Reticular Nucleus on Pentylentetrazole-Induced Seizures in Rats.

Neuromodulation 2019 Feb 11. Epub 2019 Feb 11.

Laboratorio de Neurofisiología del Control y la Regulación. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico.

Rationale: The use of electrical stimulation therapy to treat epilepsy is currently being studied in experimental animals and patients. Our study was designed to evaluate the effects of electrical stimulation applied in the thalamic reticular nucleus (TRN) on the development of pentylentetrazole-induced seizures.

Materials And Methods: Experiments were performed using male Wistar rats with electrodes stereotaxically implanted in the left TRN. Read More

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http://dx.doi.org/10.1111/ner.12926DOI Listing
February 2019
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From neuroimunomodulation to bioelectronic treatment of rheumatoid arthritis.

Bioelectron Med (Lond) 2018 May;1(2):151-165

Department of Surgery, Center of Immunology & Inflammation, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ 07101, USA.

Neuronal stimulation is an emerging field in modern medicine to control organ function and reestablish physiological homeostasis during illness. The nervous system innervates most of the peripheral organs and provides a fine tune to control the immune system. Most of these studies have focused on vagus nerve stimulation and the physiological, cellular and molecular mechanisms regulating the immune system. Read More

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http://dx.doi.org/10.2217/bem-2018-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366640PMC
May 2018
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Human caudate nucleus subdivisions in tinnitus modulation.

J Neurosurg 2019 Feb 8:1-7. Epub 2019 Feb 8.

Departments of1Otolaryngology-Head and Neck Surgery and.

OBJECTIVEThe object of this study was to define caudate nucleus locations responsive to intraoperative direct electrical stimulation for tinnitus loudness modulation and relate those locations to functional connectivity maps between caudate nucleus subdivisions and auditory cortex.METHODSSix awake study participants who underwent bilateral deep brain stimulation (DBS) electrode placement in the caudate nucleus as part of a phase I clinical trial were analyzed for tinnitus modulation in response to acute stimulation at 20 locations. Resting-state 3-T functional MRI (fMRI) was used to compare connectivity strength between centroids of tinnitus loudness-reducing or loudness-nonreducing caudate locations and the auditory cortex in the 6 DBS phase I trial participants and 14 other neuroimaging participants with a Tinnitus Functional Index > 50. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181659DOI Listing
February 2019

The dynamical signature of anhedonia in major depressive disorder: positive emotion dynamics, reactivity, and recovery.

BMC Psychiatry 2019 Feb 8;19(1):59. Epub 2019 Feb 8.

Research group of Quantitative Psychology and Individual Differences, KU Leuven, Tiensestraat 102 - bus 3713, 3000, Leuven, Belgium.

Background: Major Depressive Disorder (MDD) is the leading cause of disability worldwide. The cardinal features of MDD are depressed mood and anhedonia. Anhedonia is defined as a "markedly diminished interest or pleasure in all, or almost all, activities of the day", and has generally been investigated on group-level using retrospective data (e. Read More

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http://dx.doi.org/10.1186/s12888-018-1983-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368777PMC
February 2019

Chronic pain is underestimated and undertreated in dialysis patients: A retrospective case study.

Hemodial Int 2019 Feb 8. Epub 2019 Feb 8.

Department of Anesthesiology and Critical Care Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv University, Institute of Pain Medicine, Tel Aviv, Israel.

Significant chronic pain is highly prevalent in chronic kidney disease patients and is associated with morbidity and mortality. In this study, we retrospectively evaluated the incidence and treatment of pain in the dialysis unit of our tertiary referral center. The cohort included 147 patients. Read More

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http://dx.doi.org/10.1111/hdi.12736DOI Listing
February 2019

Polarity Specific Effects of Cross-Hemispheric tDCS Coupled With Approach-Avoidance Training on Chocolate Craving.

Front Pharmacol 2018 24;9:1500. Epub 2019 Jan 24.

Neurotherapeutics and Experimental Psychopatology Group, Psychological Neuroscience Laboratory, Centro de Investigação em Psicologia (CIPsi), School of Psychology, University of Minho, Braga, Portugal.

Transcranial Direct Current Stimulation (tDCS) over the Dorsolateral Prefrontal Cortex (DLPFC) has already been shown to decrease craving for food. However, it remains unclear whether a single session of tDCS combined with a cognitive bias modification (CBM) task may affect explicit and implicit measures of craving for chocolate. Fifty-one healthy volunteers (38 females; mean age: 22. Read More

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http://dx.doi.org/10.3389/fphar.2018.01500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353830PMC
January 2019

Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats.

Brain Stimul 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Surgery, University of California, Davis, USA; Center for Neuroscience, University of California, Davis, USA. Electronic address:

Background: Temporal lobe epilepsy is most prevalent among focal epilepsies, and nearly one-third of patients are refractory to pharmacological intervention. Persistent cognitive and neurobehavioral comorbidities also occur due to the recurrent nature of seizures and medication-related side effects.

Hypothesis: Electrical neuromodulation is an effective strategy to reduce seizures both in animal models and clinically, but its efficacy to modulate cognition remains unclear. Read More

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http://dx.doi.org/10.1016/j.brs.2019.01.005DOI Listing
January 2019

Neuromodulation of autism spectrum disorders using vagal nerve stimulation.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Cornwall Partnership NHS Foundation Trust, Threemilestone Industrial Estate, Truro TR4 9LD, UK; Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro TR1 3HD, UK. Electronic address:

Influential theories propose an important role for the autonomic nervous system in social behaviour and emotion regulation. Difficulties with these capabilities occur in autism spectrum disorders (ASD). Vagus nerve stimulation (VNS) is a neuromodulation technique that stimulates autonomic pathways by means of an electrode implanted around the left vagus nerve in the neck. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.042DOI Listing
February 2019
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Linking invasive and noninvasive neuromodulation techniques to study network properties of the brain.

Clin Neurophysiol 2019 Jan 18. Epub 2019 Jan 18.

Movement Disorder and Neuromodulation Unit, Dept. of Neurology, Charité Universitaetsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2018.12.006DOI Listing
January 2019