398,083 results match your criteria Neurology Today[Journal]


Intracranial hypertension in a patient with Class V lupus nephritis.

Nephrology (Carlton) 2019 May;24(5):585

Department of Nephrology, Liverpool Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/nep.13432DOI Listing

Meta-analysis of the prognosis of Different treatments of symptomatic moyamoya disease.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China; Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education in China and Tianjin, Tianjin Neurological Institute, Tianjin, 30052China. Electronic address:

Objective: The purpose of this study was to evaluate the efficacy of surgical revascularization versus conservative treatment and different surgical modalities, in order to provide evidence for the patient with MMD to choose the appropriate treatment.

Methods: We comprehensively searched PubMed, Embase, Web of Science and the Cochrane Library for the articles published regarding MMD treatment. If the I value, which evaluated the heterogeneity, was less than 50%, a fixed effect model was used; if not, a random effect model was applied. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.062DOI Listing

Percutaneous Transverse Sinus Cannulation for Dural Arteriovenous Fistula Coiling: Operative Video.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Neurosurgery Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

This is the case of an 84-year old woman, found to have a symptomatic transverse sinus dural arteriovenous fistula. The transverse sinus was isolated from all venous circulation and its arterial feeders stemmed from the occipital artery, precluding both arterial and venous access for effective obliteration of the fistula. Therefore, the patient underwent a combined open surgical/endovascular approach, where the sinus was percutaneously cannulated through a single burr hole, allowing access for effective coiling of the fistula. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.082DOI Listing

Evoked potentials improve multimodal prognostication after cardiac arrest.

Resuscitation 2019 Apr 14. Epub 2019 Apr 14.

Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

Aim: Predicting recovery in comatose post-cardiac arrest patients requires multiple modalities of prognostic assessment. In isolation, absent N20 cortical responses in somatosensory evoked potentials (SSEPs) are a specific predictor of poor outcome. It is unknown whether SSEP results, when assessed in the context of prior knowledge (demographic and clinical information), change the pretest predicted probability of recovery. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.011DOI Listing

Case 12-2019: A 60-Year-Old Man with Weakness and Difficulty Chewing.

N Engl J Med 2019 Apr;380(16):1566-1574

From the Department of Neurology, Brigham and Women's Hospital (C.T.D.), the Departments of Neurology (A.C.G.), Physical Medicine and Rehabilitation (S.P.), and Pathology (E.T.H.-W.), Massachusetts General Hospital, Spaulding Rehabilitation Hospital (S.P.), and the Departments of Neurology (C.T.D., A.C.G.), Physical Medicine and Rehabilitation (S.P.), and Pathology (E.T.H.-W.), Harvard Medical School - all in Boston.

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http://www.nejm.org/doi/10.1056/NEJMcpc1900141
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http://dx.doi.org/10.1056/NEJMcpc1900141DOI Listing
April 2019
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ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1644-1656

Department of Neurology, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Purpose: We investigate morphologic and physiologic alterations of ganglion cells (GCs) in a streptozocin (STZ)-induced diabetic mouse model.

Methods: Experiments were conducted in flat-mount retinas of mice 3 months after the induction of diabetes. Changes in morphology of four subtypes of GCs (ON-type RGA2 [ON-RGA2], OFF-type RGA2 [OFF-RGA2], ON-type RGC1 [ON-RGC1], and ON-OFF type RGD2 [ON-OFF RGD2]) were characterized in Thy1-YFP transgenic mice. Read More

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http://dx.doi.org/10.1167/iovs.18-26359DOI Listing

QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis.

PLoS One 2019 17;14(4):e0215162. Epub 2019 Apr 17.

University Children's Hospital, Division of Child Neurology and Metabolic Diseases, Heidelberg, Germany.

Dihydropteridine reductase (QDPR) catalyzes the recycling of tetrahydrobiopterin (BH4), a cofactor in dopamine, serotonin, and phenylalanine metabolism. QDPR-deficient patients develop neurological symptoms including hypokinesia, truncal hypotonia, intellectual disability and seizures. The underlying pathomechanisms are poorly understood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215162PLOS

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice.

PLoS Genet 2019 Apr 17;15(4):e1008069. Epub 2019 Apr 17.

Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B (CMT1B) neuropathy, one of the most diffused genetic disorders of the PNS. We previously showed that several mutations, such as the deletion of serine 63 (P0-S63del), result in misfolding and accumulation of P0 in the endoplasmic reticulum (ER), with activation of the unfolded protein response (UPR). Read More

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http://dx.plos.org/10.1371/journal.pgen.1008069
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http://dx.doi.org/10.1371/journal.pgen.1008069DOI Listing
April 2019
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Cognitive fatigue and cortical-striatal network in old age.

Aging (Albany NY) 2019 Apr 17. Epub 2019 Apr 17.

School of Nursing, University of Rochester Medical Center, Rochester, NY 14623, USA.

Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort. Here we examined the relationship between the cortical-striatal network and CF (assessed by the 18-item visual analogue scale) when a group of cognitively and physically healthy older adults participated in a 30-minute cognitively fatiguing task-related fMRI experiment. We also explored whether CF would interfere with the "Posterior-Anterior Shifting in Aging" (PASA) phenomenon, an aging-associated neural reliance on frontal regions to support cognitive capacity. Read More

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http://dx.doi.org/10.18632/aging.101915DOI Listing

Expression of OX40 Gene and its Serum Levels in Neuromyelitis Optica Patients.

Biomol Concepts 2019 Apr 11;10(1):62-67. Epub 2019 Apr 11.

Isfahan Neuroscience Research Center, Department of Neurology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Neuromyelitis optica (NMO), also known as Devic's disease, is an autoimmune disorder of the central nervous system (CNS) in which immune system cells and antibodies primarily attack the optic nerves and the spinal cord. OX40 (CD134) is a tumor necrosis factor (TNF)-receptor family member expressed primarily on activated CD4+ and CD8+ T-cells. In an autoimmune disease, OX40 is typically up-regulated at sites of inflammation, and increases in the number of peripheral CD4+ T-cells expressing OX40. Read More

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http://dx.doi.org/10.1515/bmc-2019-0007DOI Listing

Evolution of Surgical Treatment of Carotid Artery Stenosis: a single centre observational study.

Acta Chir Belg 2019 Apr 17:1-28. Epub 2019 Apr 17.

a Department of Thoracic and Vascular Surgery , Ghent University Hospital , Ghent , Belgium.

Background: In 2009 and 2011 respectively ESVS and AHA/ASA guidelines recommended to operate patients with a symptomatic carotid artery stenosis within 14 days. This study aimed primarily to determine if an academic hospital has implemented these international guidelines about indication and timing of surgical treatment of carotid stenosis. Secondary, the influence of referral from another hospital on time from symptoms to surgery and the influence of time between neurological event and surgery on 30-day complication rate was studied. Read More

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April 2019
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Galvanic vestibular stimulation: from basic concepts to clinical applications.

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Department Biology II, Ludwig-Maximilians-University Munich, Germany.

Galvanic vestibular stimulation (GVS) plays an important role in the quest to understand sensory signal processing in the vestibular system under normal and pathological conditions. It has become a highly relevant tool to probe neuronal computations and to assist in the differentiation and treatment of vestibular syndromes. Following its accidental discovery, GVS became a diagnostic tool that generates eye movements in the absence of head/body motion. Read More

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https://www.physiology.org/doi/10.1152/jn.00035.2019
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http://dx.doi.org/10.1152/jn.00035.2019DOI Listing
April 2019
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Receptor-dependence of BDNF Actions in Superficial Dorsal Horn; Relation to Central Sensitization and Actions of Macrophage Colony Stimulating Factor 1 (CSF-1).

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Neuroscience and Mental Health Institute and Dept. of Pharmacology, University of Alberta, Canada.

Peripheral nerve injury elicits an enduring increase in the excitability of the spinal dorsal horn. This change, which contributes to the development of neuropathic pain, is a consequence of release and prolonged exposure of dorsal horn neurons to various neurotrophins and cytokines. We have shown in rats that nerve injury increases excitatory synaptic drive to excitatory neurons but decreases drive to inhibitory neurons. Read More

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http://dx.doi.org/10.1152/jn.00839.2018DOI Listing

Psychometric validation of Anti-Clot Treatment Scale and Treatment Satisfaction Questionnaire for Medication version II in Japanese patients with atrial fibrillation.

J Med Econ 2019 Apr 17. Epub 2019 Apr 17.

i Modus Outcomes Ltd , Letchworth Garden City , UK.

Aims: The Anti-Clot Treatment Scale (ACTS) and Treatment Satisfaction Questionnaire for Medication version II (TSQM-II) are validated treatment satisfaction patient-reported outcome (PRO) instruments. The ACTS includes two domains: Burdens and Benefits; the TSQM-II includes four: Effectiveness, Side Effects, Convenience, and Global Satisfaction. Japanese-language versions of the ACTS and TSQM-II have been developed and linguistically validated. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609003DOI Listing

TIPE2 as a potential therapeutic target in chronic viral hepatitis.

Expert Opin Ther Targets 2019 Apr 17. Epub 2019 Apr 17.

a Department of Hepatology , Qilu Hospital of Shandong University , Jinan , China.

Introduction: Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) is a novel negative regulator of innate and adaptive immune responses by binding to caspase-8. The binding of TIPE2 and caspase-8 can inhibit the activity of activating protein-1(AP-1) and nuclear factor-κB (NF-κB), ultimately promoting Fas-induced apoptosis in immune cells. Therefore, TIPE2-caspase-8-NF-κB signaling might serve as a biomarker and a potential target for therapeutic intervention. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1608948DOI Listing
April 2019
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Quantifying the Severity of Parkinson Disease by Use of Dopaminergic Neuroimaging.

AJR Am J Roentgenol 2019 Apr 17:1-6. Epub 2019 Apr 17.

1 Department of Radiology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Parkinson disease is characterized by dopaminergic neuron loss in the substantia nigra pars compacta resulting in presynaptic nigrostriatal dopamine dysfunction. The purpose of this study was to search for an optimal image biomarker to quantify the severity of Parkinson disease by comparing neuromelanin MRI and dopamine transporter SPECT. Forty patients with Parkinson disease (Hoehn and Yahr [HY] stage 1, four patients; stage 2, 18 patients; stage 3, eight patients; stage 4, six patients; stage 5, four patients) who underwent neuromelanin MRI and dopamine transporter SPECT were included. Read More

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http://dx.doi.org/10.2214/AJR.18.20655DOI Listing

Thrombectomy of Ventricular Assist Device-Originated Embolic Stroke: A Clinical Decision Model.

J Neuroimaging 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Loyola University Chicago, Stritch School of Medicine.

Background And Purpose: The use of ventricular assist devices (VADs) for the treatment of heart failure has become increasingly common. These patients have a considerable risk of cerebral embolism. We describe such a patient and his successful treatment by thrombectomy, compare his attributes with those previously published, and describe the construct of a clinical decision model, whose results bear practical implications for patient management. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12621
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http://dx.doi.org/10.1111/jon.12621DOI Listing
April 2019
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Free Recall of Bound Information Held in Short-Term Memory is Unimpaired by Age and Education.

Arch Clin Neuropsychol 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh Campus, Edinburgh, UK.

Objectives: It has been challenging to identify cognitive markers to differentiate healthy brain aging from neurodegeneration due to Alzheimer's disease (AD) that are not affected by age and education. The Short-Term Memory Binding (STMB) showed not to be affected by age or education when using the change detection paradigm. However, no previous study has tested the effect of age and education using the free recall paradigm of the STMB. Read More

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http://dx.doi.org/10.1093/arclin/acz015DOI Listing

Pathogenic effects of agrin V1727F mutation are isoform-specific and decrease its expression and affinity for HSPGs and LRP4.

Hum Mol Genet 2019 Apr 17. Epub 2019 Apr 17.

Department of Physiology and Membrane Biology, University of California Davis, Davis, California, USA.

Agrin is a large extracellular matrix protein whose isoforms differ in their tissue distribution and function. Motoneuron-derived y+z+ agrin regulates the formation of the neuromuscular junction (NMJ), while y-z- agrin is widely expressed and has diverse functions. Previously we identified a missense mutation (V1727F) in the second laminin-G domain (LG2) of agrin that causes severe congenital myasthenic syndrome. Read More

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http://dx.doi.org/10.1093/hmg/ddz081DOI Listing

The Landscape of Parkin Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson's Disease.

Hum Mol Genet 2019 Apr 17. Epub 2019 Apr 17.

McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Mutations in Parkin (PARK2), which encodes an E3 ubiquitin ligase implicated in mitophagy, are the most common cause of early onset Parkinson's Disease (PD). Hundreds of naturally occurring Parkin variants have been reported, both in PD patient and population databases. However, the effects of the majority of these variants on the function of Parkin and in PD pathogenesis remains unknown. Read More

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http://dx.doi.org/10.1093/hmg/ddz080DOI Listing

Metastasis from glioblastoma multiforme: a meta-analysis.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):424-433. Epub 2019 Apr 11.

Chairman of the Program of Postgraduation in Neurooncology of the Teaching and Research Institute at Hospital Sirio-Libanês, São Paulo, SP.

Objective: Extracranial metastases of glioblastoma multiforme (GBM) are rare due to the short survival experienced by the patients. Therefore, the natural history of GBM metastases remains elusive. The identification of clinical factors promoting GBM metastases may help elucidate the mechanisms of tumor cell invasion in the brain. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.424DOI Listing
March 2019
1 Read

Hydrogen sulfide protects H9c2 cardiomyoblasts against H2O2-induced apoptosis.

Braz J Med Biol Res 2019 15;52(4):e7626. Epub 2019 Apr 15.

Department of Intensive Care Unit, Renmin Hospital, Hubei University of Medicine, Shiyan, China.

Reactive oxygen species (ROS) are highly reactive chemical species that may cause irreversible tissue damage, and play a critical role in cardiovascular diseases. Hydrogen sulfide (H2S) is a gasotransmitter that acts as a ROS scavenger with cardio-protective effects. In this study, we investigated the cytoprotective effect of H2S against H2O2-induced apoptosis in cardiomyocytes. Read More

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http://dx.doi.org/10.1590/1414-431X20187626DOI Listing

Prevention of catheter-associated urinary tract infection in neurological post-operation patients: a best practice implementation project.

JBI Database System Rev Implement Rep 2019 Apr 15. Epub 2019 Apr 15.

Indiana Center for Evidence Based Nursing Practice: a Joanna Briggs Institute Affiliated Group.

Objective: The objective of this evidence based implementation project was to promote evidence based practice in the prevention of catheter-associated urinary tract infection (CAUTI) in the neurology and neurosurgery units of a Taipei hospital.

Introduction: Catheter-associated urinary tract infection has been associated with increased morbidity, mortality, hospital costs and length of stay. Urinary drainage systems are often reservoirs of infection in patients, thus effective prevention of CAUTI requires an evidence-based approach. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003945DOI Listing

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.

Elife 2019 Apr 17;8. Epub 2019 Apr 17.

Department of Neurology, University of Texas Medical Branch, Galveston, United States.

How huntingtin (HTT) triggers neurotoxicity in Huntington's disease (HD) remains unclear. We report that HTT forms a transcription-coupled DNA repair (TCR) complex with RNA polymerase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucleotide-kinase-3'-phosphatase (PNKP), and cyclic AMP-response element-binding (CREB) protein (CBP). This complex senses and facilitates DNA damage repair during transcriptional elongation, but its functional integrity is impaired by mutant HTT. Read More

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https://elifesciences.org/articles/42988
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http://dx.doi.org/10.7554/eLife.42988DOI Listing
April 2019
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Affective theory of mind in human aging: is there any relation with executive functioning?

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Apr 17:1-13. Epub 2019 Apr 17.

c Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit , Istanbul University , Istanbul , Turkey.

Theory of Mind (ToM) refers to the ability to make inferences on other's mental or emotional states. Although there is evidence suggesting that impaired executive functions due to aging could have a negative impact on cognitive ToM, there is still controversy about the effect of age and age-related executive dysfunctions on affective ToM. To investigate affective ToM in healthy aging and its relationship with executive functions, we examined Reading Mind in the Eyes Test (RMET) performance and executive functions among young and older adults. Read More

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http://dx.doi.org/10.1080/13825585.2019.1602706DOI Listing

Classic galactosaemia in the Greek Cypriot population: An epidemiological and molecular study.

Ann Hum Genet 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemical Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

Classic galactosaemia is an inherited metabolic disorder of galactose metabolism caused by deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT) resulting from mutations in the GALT gene. The objectives of the present study were the determination of the carrier frequency of classic galactosaemia in the Greek Cypriot population and the molecular characterization of the disease alleles. We performed an epidemiological study involving 528 Greek Cypriots originating from all parts of Cyprus. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ahg.12318
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http://dx.doi.org/10.1111/ahg.12318DOI Listing
April 2019
1 Read

Increasing use of immunotherapy and prolonged survival among younger patients with primary CNS lymphoma: a population-based study.

Acta Oncol 2019 Apr 17:1-10. Epub 2019 Apr 17.

a Institute of Neurology , Medical University of Vienna , Vienna , Austria.

Background: Primary CNS lymphoma is a highly aggressive and rare type of extranodal non-Hodgkin lymphoma. Although, new therapeutic approaches have led to improved survival, the management of the disease poses a challenge, practice patterns vary across institutions and countries, and remain ill-defined for vulnerable patient subgroups.

Material And Methods: Using information from the Austrian Brain Tumor Registry we followed a population-based cohort of 189 patients newly diagnosed from 2005 to 2010 through various lines of treatment until death or last follow-up (12-31-2016). Read More

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http://dx.doi.org/10.1080/0284186X.2019.1599137DOI Listing

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes.

J Am Heart Assoc 2019 May;8(9):e011201

2 Hubrecht Institute (Royal Netherlands Academy of Arts and Sciences (KNAW)) University Medical Center, Utrecht the Netherlands.

Background We previously showed that intracranial aneurysm ( IA )-associated single-nucleotide polymorphisms are enriched in promoters and putative enhancers identified in the human circle of Willis, on which IA s develop, suggesting a role for promoters and enhancers in IAs . We further investigated the role of putative enhancers in the pathogenesis of IA by identifying their potential target genes and validating their regulatory activity. Methods and Results Using our previously published circle of Willis chromatin immunoprecipitation and sequencing data, we selected 34 putative enhancers in IA -associated regions from genome-wide association studies. Read More

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http://dx.doi.org/10.1161/JAHA.118.011201DOI Listing

Machine-learning identifies parkinson's disease patients based on resting-state between-network functional connectivity.

Br J Radiol 2019 Apr 17:20180886. Epub 2019 Apr 17.

1 Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty , Dusseldorf , Germany.

Objectives: Evaluation of a data-driven, model-based classification approach to discriminate idiopathic Parkinson's disease (PD) patients from healthy controls (HC) based on between-network connectivity in whole-brain resting-state functional MRI (rs-fMRI).

Methods: Whole-brain rs-fMRI (EPI/TR = 2.2  s/TE = 30  ms/flip angle = 90°/resolution = 3. Read More

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http://dx.doi.org/10.1259/bjr.20180886DOI Listing

A Challenging Case of Tapia Syndrome After Total Thyroidectomy.

Ear Nose Throat J 2019 Apr 17:145561319841202. Epub 2019 Apr 17.

2 Department of Neurology, Umraniye Education and Research Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1177/0145561319841202DOI Listing

Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity.

Diabetes Metab J 2019 Apr;43(2):144-155

Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

Obstructive sleep apnea (OSA) and diabetes has been known to be closely related to each other and both diseases impact highly on the public health. There are many evidence of reports that OSA is associated with diabetes with a bidirectional correlation. A possible causal mechanism of OSA to diabetes is intermittent hypoxemia and diabetes to OSA is microvascular complication. Read More

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http://dx.doi.org/10.4093/dmj.2018.0256DOI Listing

IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells.

Mol Genet Genomic Med 2019 Apr 16:e686. Epub 2019 Apr 16.

Vanderbilt Center for Undiagnosed Disease, Vanderbilt University, Nashville, Tennessee.

Background: Family screening of a 48-year-old male with recently diagnosed IgG4-related disease (IgG4-RD) revealed unanticipated elevations in plasma IgG4 in his two healthy teenaged sons.

Methods: We performed gene sequencing, immune cell studies, HLA typing, and analyses of circulating cytotoxic CD4+ T lymphocytes and plasmablasts to seek clues to pathogenesis. DNA from a separate cohort of 99 patients with known IgG4-RD was also sequenced for the presence of genetic variants in a specific gene, FGFBP2. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.686
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http://dx.doi.org/10.1002/mgg3.686DOI Listing
April 2019
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Mouse Extraocular Muscles and the Musculotopic Organization of their Innervation.

Anat Rec (Hoboken) 2019 Apr 16. Epub 2019 Apr 16.

Departments of Neurobiology & Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.

The organization of extraocular muscles and their motor nuclei was investigated in the mouse due to the increased importance of this model for oculomotor research. Mice showed a standard extraocular muscle organization pattern, although their eyes are set at the side of the head. They do have more prominent oblique muscles, whose insertion points differ from those of frontal-eyed species. Read More

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http://dx.doi.org/10.1002/ar.24141DOI Listing

Evaluation of an Online Residency Training in Tobacco Use Disorder.

Am J Addict 2019 Apr 16. Epub 2019 Apr 16.

Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey.

Background And Objectives: Despite the overwhelming need for tobacco use disorder (TUD) treatment in behavioral health settings, few models have emerged for training psychiatry residents. One barrier may be a lack of curricula or faculty expertize in this area. The goal of this project was to develop and evaluate a 3 hour online webinar-based course for teaching psychiatry residents about TUD. Read More

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http://dx.doi.org/10.1111/ajad.12885DOI Listing

Intermittent glucocorticoid regimes for younger boys with Duchenne muscular dystrophy: balancing efficacy with side-effects.

Authors:
Hugh J McMillan

Muscle Nerve 2019 Apr 17. Epub 2019 Apr 17.

Division of Neurology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1002/mus.26490DOI Listing

Treatment in childhood central nervous system demyelinating disorders.

Dev Med Child Neurol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatric Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

The last two decades witnessed significant advances in the treatment of acquired demyelinating disorders: thirteen new agents have been approved for the treatment of multiple sclerosis in adults by the European Medicines Agency and US Food and Drug Administration in the last twenty years. Although the long-term efficacy and safety profiles of some new drugs are still being assessed in paediatric MS, clinicians may have to use them in the management of paediatric onset MS resistant to first-line medications, based on results obtained in adult-onset disease. This review summarizes the current approach to treatment in children with demyelinating syndromes. Read More

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http://dx.doi.org/10.1111/dmcn.14228DOI Listing

Trends in phenotype in the English paediatric Neurofibromatosis Type 2 cohort stratified by genetic severity.

Clin Genet 2019 Apr 16. Epub 2019 Apr 16.

Oxford NF2 Unit, Oxford University Hospitals NHS Foundation Trust.

Childhood onset neurofibromatosis type 2 can be severe and genotype dependent. We present a retrospective phenotypic analysis of all ascertained children in England Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13551
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http://dx.doi.org/10.1111/cge.13551DOI Listing
April 2019
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Cannabis derived medicinal products in child neurology.

Dev Med Child Neurol 2019 Apr 16. Epub 2019 Apr 16.

Paediatric Neuroscience, UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1111/dmcn.14232DOI Listing

Medical treatment for botulism.

Cochrane Database Syst Rev 2019 Apr 17;4:CD008123. Epub 2019 Apr 17.

Department of Neurology & Neurosurgery, McGill University, Montreal General Hospital - Room L7-313, 1650 Cedar Avenue, Montreal, QC, Canada, H3G 1A4.

Background: Botulism is an acute paralytic illness caused by a neurotoxin produced by Clostridium botulinum. Supportive care, including intensive care, is key, but the role of other medical treatments is unclear. This is an update of a review first published in 2011. Read More

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http://doi.wiley.com/10.1002/14651858.CD008123.pub4
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http://dx.doi.org/10.1002/14651858.CD008123.pub4DOI Listing
April 2019
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CADASIL with Atypical Clinical Symptoms, Magnetic Resonance Imaging, and Novel Mutations: Two Case Reports and a Review of the Literature.

J Mol Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Celal Bayar University, 45000, Manisa, Turkey.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy with adult onset caused by a missense mutation in the NOTCH3 gene in chromosome 19p13. It presents with autosomal dominant arteriopathy, subcortical infarctions, and leukoencephalopathy. Its common clinical presentations are seen as recurrent strokes, migraine or migraine-like headaches, progressive dementia, pseudobulbar paralysis, and psychiatric conditions. Read More

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http://dx.doi.org/10.1007/s12031-019-01313-zDOI Listing

Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care.

Ann Intensive Care 2019 Apr 16;9(1):47. Epub 2019 Apr 16.

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.

The 2018 Paris Intensive Care symposium entitled "Update in Neurocritical Care" was organized in Paris, June 21-22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educational symposium comprised several chapters, aiming first to provide all-board intensivists with current standards for the clinical assessment of altered consciousness states (including coma and delirium) and peripheral nervous system in critically ill patients, monitoring of brain function (specifically, electro-encephalography) and best practices for sedation-analgesia-delirium management. An update on the treatment of specific severe brain pathologies-including ischaemic/haemorrhagic stroke, cerebral venous thrombosis, hypoxic-ischaemic brain injury, immune-mediated and infectious encephalitis and refractory status epilepticus-was also provided. Read More

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http://dx.doi.org/10.1186/s13613-019-0523-xDOI Listing

The role of caveolin-1 in tumors of the brain - functional and clinical implications.

Cell Oncol (Dordr) 2019 Apr 16. Epub 2019 Apr 16.

Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA.

Background: Caveolin-1 (cav-1) is the major structural protein of caveolae, the flask-shaped invaginations of the plasma membrane mainly involved in cell signaling. Today, cav-1 is believed to play a role in a variety of disease processes including cancer, owing to the variations of its expression in association with tumor progression, invasive behavior, metastasis and therapy resistance. Since first detected in the brain, a number of studies has particularly focused on the role of cav-1 in the various steps of brain tumorigenesis. Read More

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http://link.springer.com/10.1007/s13402-019-00447-x
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http://dx.doi.org/10.1007/s13402-019-00447-xDOI Listing
April 2019
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The Responsiveness of Triaxial Accelerometer Measurement of Gait Ataxia Is Higher than That of the Scale for the Assessment and Rating of Ataxia in the Early Stages of Spinocerebellar Degeneration.

Cerebellum 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, 060-8638, Japan.

We reported previously that the average medial-lateral gait amplitude while walking on a straight path determined using triaxial accelerometers fixed on the middle of the upper back may be a quantitative and concise indicator for the severity of cerebellar ataxia. Considering that gait ataxia is a typical initial symptom in a variety of spinocerebellar degeneration (SCD), we aimed to develop quantitative biomarkers for cerebellar ataxia as metric variables. We used triaxial accelerometers to analyze gait parameters in 14 patients with SCD at 3 points over 3 years (at baseline, 1. Read More

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http://dx.doi.org/10.1007/s12311-019-01025-5DOI Listing

Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach.

Eur J Epidemiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

Chronological age alone is not a sufficient measure of the true physiological state of the body. The aims of the present study were to: (1) quantify biological age based on a physiological biomarker composite model; (2) and evaluate its association with death and age-related disease onset in the setting of an elderly population. Using structural equation modeling we computed biological age for 1699 individuals recruited from the first and second waves of the Rotterdam study. Read More

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http://dx.doi.org/10.1007/s10654-019-00497-3DOI Listing

Chronic lower leg pain: entrapment of common peroneal nerve or tibial nerve.

Unfallchirurg 2019 Apr 16. Epub 2019 Apr 16.

Departments of Surgery, Neurology and Sports Medicine, Maxima Medical Center, De Run 4600, 7777, 5500 MB, Veldhoven, The Netherlands.

Young individuals with chronic exercise-induced lower leg pain (ELP) who have normal compartmental muscle pressures and normal imaging occasionally suffer from a nerve entrapment syndrome. These patients have consistently undergone a variety of diagnostic tests and often futile therapies prior to arriving at the correct diagnosis. Awareness among traumatologists regarding these nerve entities is low. Read More

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http://dx.doi.org/10.1007/s00113-019-0645-5DOI Listing

Work Related Violence As A Predictor Of Stress And Correlated Disorders In Emergency Department Healthcare Professionals.

Clin Ter 2019 Mar-Apr;170(2):e110-e123

Department of Neurology and Psychiatry University of Rome Sapienza.

Aims: The aim of the study was to investigate the frequency, type, causes and consequences of violence and aggression experienced by Emergency Department workers during their interactions with patient, their relatives or companions and whether the phenomenon of violence at work is a specific risk factor predicting stress and possible stress related pathologies in emergency health workers. The study proposes a model of effective intervention for the prevention and management of violence and stress.

Methods: A cross-sectional retrospective study was performed with a sample of 323 healthcare workers at Department of Emergency and Acceptance of Level II and the Psychiatric Services of Diagnosis and Care of the University Hospital Policlinico Umberto I, in Rome, Italy, between June 2016 and February 2017. Read More

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http://dx.doi.org/10.7417/CT.2019.2120DOI Listing

"Klingon headache" - a case report of mimic new daily persistent headache associated to primary essential cutis verticis gyrata.

Clin Ter 2019 Mar-Apr;170(2):e77-e80

Pain Center "Enzo Borzomati", University Hospital of Rome "Policlinico Umberto I", Rome.

Background: Primary essential cutis verticis gyrata is a condition that usually affects healthy subjects associated to convoluted folds and furrows formed from thickened skin of the scalp resembling cerebriform pattern.

Case: we describe a case of association between primary essential cutis verticis gyrata and new daily persistent headache.

Discussion/conclusions: In our knowledge this is the first description of new daily persistent headache associated with primary essential cutis verticis gyrata. Read More

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http://dx.doi.org/10.7417/CT.2019.2112DOI Listing

Artificial intelligence-Developments in medicine in the last two years.

Chronic Dis Transl Med 2019 Mar 9;5(1):64-68. Epub 2019 Jan 9.

Ufa State Aviation Technical University Institute of Aviation Technological Systems, Ufa 450077, Russia.

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http://dx.doi.org/10.1016/j.cdtm.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449768PMC

Examining the Inter Hemispheric Transfer Time Test: A new computerized cognitive test to incorporate into therapeutic strategy for patients with brain metastases? A pilot study.

Clin Transl Radiat Oncol 2019 May 20;16:48-54. Epub 2018 Nov 20.

INSERM CIC 1402, CHU, Poitiers, France.

Objective: To evaluate the computerized Inter Hemispheric Transfer Time Test (IHTTT), a cognitive test designed for the detection of information processing speed impairment in patients undergoing stereotactic radiation therapy for brain metastases.

Methods: Inclusion criteria: age ≥18 years, brain metastases treated by stereotactic radiotherapy (SRT) with dose schedule: 33 Gy in 3 fractions, solid tumour, ≥70 Karnofsky Performance Status, Mini-Mental State Evaluation (MMSE) ≥ 24, no history of stroke brain injury. Twenty-nine patients were recruited from June 2014 to April 2015. Read More

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http://dx.doi.org/10.1016/j.ctro.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449743PMC

The Clinical and Vascular Characteristics of RNF213 c.14576G>A Variant-Related Intracranial Major Artery Disease in China.

Behav Neurol 2019 12;2019:7908392. Epub 2019 Mar 12.

Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Background And Purpose: Recently, several studies indicated the c.14576G>A variant on the ring finger protein 213 (RNF213), a founder variant of moyamoya diseases (MMD), was associated with non-MMD intracranial major artery stenosis/occlusion (non-MMD ICASO). We proposed that RNF213 variant-related ICASO including MMD might be a special entity with its own characteristics based on a genetic background. Read More

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https://www.hindawi.com/journals/bn/2019/7908392/
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http://dx.doi.org/10.1155/2019/7908392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434291PMC
March 2019
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