392,243 results match your criteria Neurology Today[Journal]


Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia.

Neuropsychopharmacology 2019 Feb 22. Epub 2019 Feb 22.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Previously, we demonstrated that dendritic spine density (DSD) in deep layer 3 of the primary auditory cortex (A1) lower, due to having fewer small spines, in subjects with schizophrenia (SZ) than non-psychiatric control (NPC) subjects. We also previously demonstrated that microtubule-associated-protein-2 immunoreactivity (MAP2-IR) in A1 deep layer 3 is lower, and positively correlated with DSD, in SZ subjects. Here, we first sought to confirm these findings in an independent cohort of 25 SZ-NPC subject pairs (cohort 1). Read More

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http://dx.doi.org/10.1038/s41386-019-0350-7DOI Listing
February 2019

Unilateral Thalamic Deep Brain Stimulation vs. Focused Ultrasound Thalamotomy for Essential Tremor.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Departments of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: The predominant neurosurgical approach to medication-refractory essential tremor (ET) is thalamic deep brain stimulation (DBS). The emergence of magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy has reawakened the debate surrounding the use of DBS vs. thalamotomy for this indication. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.281DOI Listing
February 2019

Impact of dual-layer duraplasty during hemicraniectomy on morbidity and operative metrics of cranioplasty; a retrospective case-control study comparing a single to dual-layer technique.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/j.wneu.2019.01.276DOI Listing
February 2019

Diagnostic and prognostic potential of serum cell-free microRNA-214 in glioma.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Linyi People's Hospital, Shandong University, Linyi, Shandong Province, China. Electronic address:

Objectives: We aimed to expound feasibility of serum cell-free microRNA-214 (miR-214) as a noninvasive biomarker for glioma in this study.

Patients And Methods: We detected expression of miR-214 in medium from 2 glioma cell lines to confirm whether it is secretory in screening phase. Then we verified cell-free miR-214 expression in serum samples from an independent set of 100 preoperative glioma patients, 30 matching postoperative patients and 100 healthy controls. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.009DOI Listing
February 2019

AUTOLOGOUS HEMATOPOIETIC CELL TRANSPLANTATION FOR TREATMENT-REFRACTORY RELAPSING MULTIPLE SCLEROSIS: POSITION STATEMENT FROM THE AMERICAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Multiple sclerosis (MS) is a chronic, disabling, immune-mediated, central nervous system demyelinating and degenerative disease. Approved disease modifying therapies may be incompletely effective in some patients with highly active relapsing disease and high risk of disability. Immunoablative or myeloablative therapy followed by autologous hematopoietic cell transplantation (AHCT) has been investigated in retrospective studies, clinical trials, and meta-analyses/systematic reviews as an approach to address this unmet clinical need. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.014DOI Listing
February 2019

Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates pathological cardiac hypertrophy through miR-155-mediated IKKi signaling.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 19. Epub 2019 Feb 19.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China; Department of Cardiology, The Fifth Affiliated Hospital of Xin Jiang Medical University, Urumchi 830001, China; Qianjiang Central Hospital of Hubei Province, Qianjiang 433100, China. Electronic address:

Pathological cardiac hypertrophy, which may lead to heart failure and sudden death, can be affected by multiple factors. In our previous study, we revealed that IKKi deficiency induced cardiac hypertrophy through the activation of the AKT and NF-kB signaling pathway in response to aortic banding (AB). Non-coding RNAs, mainly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial role in normal developmental and pathological processes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.014DOI Listing
February 2019

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.

Cell 2019 Feb;176(5):1143-1157.e13

Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Electronic address:

We tested a newly described molecular memory system, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre-motor cortex leads to early recovery of motor control. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.044DOI Listing
February 2019

Impact of a selective cyclooxygenase-2 inhibitor, celecoxib, on cortical excitability and electrophysiological properties of the brain in healthy volunteers: A randomized, double-blind, placebo-controlled study.

PLoS One 2019 22;14(2):e0212689. Epub 2019 Feb 22.

Department of Neurology, Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.

The inflammatory response is considered a defence mechanism against physical or infectious insults and is prevalent within the central nervous system. Seizures also result in a robust inflammatory cascade, leading to enhanced activation of excitatory synaptic networks. Ample evidence based on animal models of epilepsy has demonstrated that celecoxib, a highly selective inhibitor of cyclooxygenase-2, has anticonvulsant effects. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212689PLOS
February 2019

Feasibility of integrated, multilevel care for cardiovascular diseases (CVD) and HIV in low- and middle-income countries (LMICs): A scoping review.

PLoS One 2019 22;14(2):e0212296. Epub 2019 Feb 22.

Department of Epidemiology, New York University College of Global Public Health, New York, New York, United States of America.

Background: Integrated cardiovascular disease (CVD) and HIV (CVD-HIV) care interventions are being adopted to tackle the growing burden of noncommunicable diseases (NCDs) in low-and middle-income countries (LMICs) but there is a paucity of studies on the feasibility of these interventions in LMICs. This scoping review aims to present evidence of the feasibility of integrated CVD-HIV care in LMICs, and the alignment of feasibility reporting in LMICs with the existing implementation science methodology.

Methods: A systematic search of published articles including systematic and narrative reviews that reported on integrated CVD-HIV care was conducted, using multiple search engines including PubMed/Medline, Global Health, and Web of Science. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212296PLOS
February 2019

CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review.

PLoS One 2019 22;14(2):e0212198. Epub 2019 Feb 22.

Friedrich Baur Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.

Introduction: The system of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (cas) is a new technology that allows easier manipulation of the genome. Its potential to edit genes opened a new door in treatment development for incurable neurological monogenic diseases (NMGDs). The aim of this systematic review was to summarise the findings on the current development of CRISPR-cas for therapeutic purposes in the most frequent NMGDs and provide critical assessment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212198PLOS
February 2019

Cognitive functions and jugular venous reflux in severe mitral regurgitation: A pilot study.

PLoS One 2019 22;14(2):e0207832. Epub 2019 Feb 22.

School of Medicine, National Yang Ming University, Taipei, Taiwan.

Cardiac diseases with elevated central venous pressure have higher frequency of jugular venous reflux (JVR), which is associated with decreased cerebral blood flow and white matter hyperintensities. Whether patients with severe mitral-regurgitation (SMR) have poorer cognitive functions and whether JVR is involved were determined in this pilot study. Patients with SMR and age/sex-matched controls were prospectively recruited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207832PLOS
February 2019

[Epidemiological and Etiological Characteristics of Myelopathies in the Neurology Department of the University Hospital Center of Cocody, Abidjan (Ivory Coast)].

Bull Soc Pathol Exot 2018 ;111(4):201-204

Service de neurologie, CHU de Cocody, BP V 13 Abidjan, Côte-d'Ivoire.

The term myelopathy defines a suffering of the spinal cord whatever the etiologies. They often represent real therapeutic emergencies and are burdened by serious functional sequelae. The aim of this work was to describe the epidemiological, clinical, and etiological aspects of all myelopathies. Read More

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http://dx.doi.org/10.3166/bspe-2018-0043DOI Listing
January 2018

The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation.

Sleep 2019 Feb 22. Epub 2019 Feb 22.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing vs planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates. Read More

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http://dx.doi.org/10.1093/sleep/zsz050DOI Listing
February 2019

Brief (<4 hour) sleep episodes are insufficient for restoring performance in first-year resident physicians working overnight extended-duration work shifts.

Sleep 2019 Feb 22. Epub 2019 Feb 22.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, USA.

Study Objectives: The Accreditation Council for Graduate Medical Education (ACGME) recently reinstated extended-duration (24-28 hour) work shifts (EDWS) for postgraduate year 1 (PGY-1) resident physicians. This study examined the relationship between overnight sleep duration during EDWS and subsequent 'post-call' performance in PGY-1 resident physicians.

Methods: Thirty-four PGY-1 resident physicians (23 males; 24-32 years) were studied between 2002-2004 during three-week Q3 'on-call' rotation schedules in the Medical and Cardiac Intensive Care Units at Brigham and Women's Hospital in Boston. Read More

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http://dx.doi.org/10.1093/sleep/zsz041DOI Listing
February 2019

Validation and iteration of CT perfusion defined malignant profile thresholds for acute ischemic stroke.

Int J Stroke 2019 Feb 22:1747493019832987. Epub 2019 Feb 22.

1 Department of Neurology, University of California, San Francisco, CA, USA.

Background: Malignant profile computed tomography perfusion (CTP) lesions are associated with poor outcomes after administration of intravenous tissue-plasminogen activator (IV-tPA) for ischemic stroke.

Aims: To determine whether published CTP-based lesion thresholds predictive of poor outcomes in a predominantly 8 cm of CTP anatomic coverage cohort would predict poor outcomes in an independent 4 cm of CTP anatomic coverage cohort and to generate optimized 4 cm CTP thresholds.

Methods: Ischemic stroke patients with baseline CTP imaging with 4 cm of anatomic coverage before receiving IV-tPA at a single institution were retrospectively studied. Read More

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http://dx.doi.org/10.1177/1747493019832987DOI Listing
February 2019

The Association of Very Early Serum levels of S100B, GFAP, UCH-L1, and SBDP with Outcome in ProTECT III.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

Emory University, Emergency Medicine , Emergency Medicine Research Center , 49 Jesse Hill Jr. Dr. , Atlanta, Georgia, United States , 30303 ;

Rapid risk-stratification of patients with acute traumatic brain injury (TBI) would inform management decisions and prognostication. The objective of this serum biomarker study (BIO-ProTECT) was to test the hypothesis that serum biomarkers of structural brain injury, measured at a single very early timepoint, add value beyond relevant clinical covariates when predicting unfavorable outcome 6-months after moderate-to-severe acute TBI. BIO-ProTECT utilized prospectively collected samples obtained from subjects with moderate-to-severe TBI enrolled in the ProTECT III clinical trial of progesterone. Read More

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http://dx.doi.org/10.1089/neu.2018.5809DOI Listing
February 2019

Mental Illness, Not Obesity Status, is Associated with Food Insecurity Among the Elderly in the Health and Retirement Study.

J Nutr Gerontol Geriatr 2019 Feb 22:1-24. Epub 2019 Feb 22.

g Providence VA Medical Center , Center of Innovation in Long-Term Services and Supports , Providence , RI , USA.

Objectives: Food insecurity, limited or uncertain access to adequate nutrition, is an increasingly recognized determinant of health outcomes and is often associated with having obesity. It is unclear, however, if this association persists in elderly populations.

Methods: We conducted a cross-sectional study of 2868 participants' aged 65+ years from the Health and Retirement Study. Read More

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http://dx.doi.org/10.1080/21551197.2019.1565901DOI Listing
February 2019

Capture and display of antibodies secreted by hybridoma cells enables fluorescent on-cell screening.

MAbs 2019 Feb 22:1-13. Epub 2019 Feb 22.

a Lankenau Institute for Medical Research , Wynnewood , PA , USA.

Hybridoma methods for monoclonal antibody (mAb) cloning are a mainstay of biomedical research, but they are hindered by the need to maintain hybridomas in oligoclonal pools during antibody screening. Here, we describe a system in which hybridomas specifically capture and display the mAbs they secrete: On-Cell mAb Screening (OCMS™). In OCMS™, mAbs displayed on the cell surface can be rapidly assayed for expression level and binding specificity using fluorescent antigens with high-content (image-based) methods or flow cytometry. Read More

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http://dx.doi.org/10.1080/19420862.2019.1574520DOI Listing
February 2019

Performance validity measures in clinical patients with aphasia.

J Clin Exp Neuropsychol 2019 Feb 22:1-8. Epub 2019 Feb 22.

a Department of Neurology , Medical University of Innsbruck , Innsbruck , Austria.

Introduction: Performance validity testing has developed into an indispensible element of neuropsychological assessment, mostly applied in forensic determinations. Its aim is to distinguish genuine patient performance from invalid test profiles. Limits to the applicability of performance validity tests (PVTs) may arise when genuine cognitive symptoms are present. Read More

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http://dx.doi.org/10.1080/13803395.2019.1579783DOI Listing
February 2019

Acute Effect of Caffeine on Pattern-Reversal Visual Evoked Potential: A Randomized-Controlled Study.

Cutan Ocul Toxicol 2019 Feb 22:1-12. Epub 2019 Feb 22.

c Ege University Medical Faculty, Department of Neurology , Izmir , Turkey.

Purpose: This study was aimed to investigate the acute effect of caffeine intake on pattern-reversal (PR) visual evoked potential (VEP).

Methods: This randomized controlled study included 40 participants who were divided into two groups randomly (group 1 [study group, n = 20] and group 2 [control group, n = 20]). While the study group received coffee beverages made from 6 grams pure coffee beans (36 mg of caffeine per gram) containing approximately 216 mg caffeine, the control group was given beverages containing 200 mg lactose without caffeine. Read More

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http://dx.doi.org/10.1080/15569527.2019.1583248DOI Listing
February 2019

Early diagnosis of ATTR amyloidosis through targeted follow-up of identified carriers of TTR gene mutations.

Amyloid 2019 Feb 22:1-7. Epub 2019 Feb 22.

k Department of Neurology , Kumamoto University , Kumamoto , Japan.

Diagnosis in the early stages of hereditary transthyretin (ATTR) amyloidosis is imperative to support timely treatment to prevent or delay disease progression. Genetic testing in the setting of genetic counselling enables identification of carriers of a TTR gene mutation who are therefore at risk of developing TTR-associated disease. Knowledge of different genotypes and how they manifest in symptomatic disease should facilitate development of a structured and targeted approach to enable diagnosis of symptomatic disease in ATTR amyloidosis mutation carriers on the first manifestation of the earliest detectable sign or symptom. Read More

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http://dx.doi.org/10.1080/13506129.2018.1556156DOI Listing
February 2019

Emerging patterns in HIV-1 gp120 variable domains in anatomical tissues in the absence of a plasma viral load.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

The AIDS and Cancer Specimen Resource , University of California, San Francisco , San Francisco, United States , 94121.

The HIV envelope protein contains five hypervariable domains (V1-V5) that are fundamental for cell entry. We contrasted modifications in the variable domains derived from a panel of 24 tissues from 7 subjects with no measurable plasma viral load (NPVL) to variable domains from 76 tissues from 15 subjects who had a detectable plasma viral load (PVL) at death. NPVL subject's V1 and V2 domains were usually highly length variable, whereas length variation in PVL sequences was more conserved. Read More

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http://dx.doi.org/10.1089/AID.2018.0267DOI Listing
February 2019

Association between working hours, work engagement, and work productivity in employees: A cross-sectional study of the Japanese Study of Health, Occupation, and Psychosocial Factors Relates Equity.

J Occup Health 2019 Feb 22. Epub 2019 Feb 22.

Department of Public Health, Kitasato University School of Medicine, Sagamihara, Japan.

Objectives: The aims of the study were to investigate the association between working hours, work engagement, and work productivity, and to examine if work engagement moderates the influence of working hours on work productivity.

Methods: We used cross-sectional data from the Japanese occupational cohort survey, which involved 2093 employees in a manufacturing industry. Working hours were self-reported by the study participants. Read More

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http://dx.doi.org/10.1002/1348-9585.12023DOI Listing
February 2019

The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma.

Magn Reson Med 2019 Feb 22. Epub 2019 Feb 22.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, Maryland.

Purpose: The mammalian target of rapamycin is an enzyme that regulates cell metabolism and proliferation. It is up-regulated in aggressive tumors, such as glioblastoma, leading to increased glucose uptake and consumption. It has been suggested that glucose CEST signals reflect the delivery and tumor uptake of glucose. Read More

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http://dx.doi.org/10.1002/mrm.27683DOI Listing
February 2019

The genotypic spectrum of ALDH7A1 mutations resulting in pyridoxine dependent epilepsy: A common epileptic encephalopathy.

J Inherit Metab Dis 2019 Feb 22. Epub 2019 Feb 22.

Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Pyridoxine dependent epilepsy (PDE) is a treatable epileptic encephalopathy characterized by a positive response to pharmacologic doses of pyridoxine. Despite seizure control, at least 75% of individuals have intellectual disability and developmental delay. Current treatment paradigms have resulted in improved cognitive outcomes emphasizing the importance of an early diagnosis. Read More

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http://dx.doi.org/10.1002/jimd.12045DOI Listing
February 2019

Successful treatment of refractory mechanic's hands with ustekinumab in a patient with the antisynthetase syndrome.

Rheumatology (Oxford) 2019 Feb 21. Epub 2019 Feb 21.

Muscle Disease Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, USA.

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http://dx.doi.org/10.1093/rheumatology/kez020DOI Listing
February 2019

Screening for Post-Stroke Depression and Cognitive Impairment at Baseline Predicts Long-Term Patient-Centered Outcomes After Stroke.

J Geriatr Psychiatry Neurol 2019 Jan;32(1):40-48

1 Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Background:: Independence and reintegration into community roles are important patient-centered outcomes after stroke. Depression and cognitive impairment are common post-stroke conditions that may impair long-term function even years after a stroke. However, screening for these post-stroke comorbidities remains infrequent in stroke prevention clinics and the utility of this screening for predicting long-term higher-level function has not been evaluated. Read More

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http://dx.doi.org/10.1177/0891988718819859DOI Listing
January 2019

Accuracy and safety of B-scan optic nerve ultrasonography to predict increased intracranial pressure in idiopathic intracranial hypertension.

Neuroradiol J 2019 Feb 22:1971400919831463. Epub 2019 Feb 22.

Department of Neurology, Cairo University, Egypt.

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http://dx.doi.org/10.1177/1971400919831463DOI Listing
February 2019

Mental illness and obesity among Veterans undergoing percutaneous coronary intervention: Insights from the VA CART program.

Clin Obes 2019 Feb 21:e12300. Epub 2019 Feb 21.

Division of Cardiology, Anschutz School of Medicine, University of Colorado, Aurora, CO, USA.

Mental illness and obesity are highly prevalent in patients with coronary disease and are frequently comorbid. While mental illness is an established risk factor for major adverse cardiac and cerebrovascular events (MACCEs), prior studies suggest improved outcomes in people with obesity. It is unknown if obesity and mental illness interact to affect cardiac outcomes or if they independently influence MACCE. Read More

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http://dx.doi.org/10.1111/cob.12300DOI Listing
February 2019

Inhibition of P53/miR-34a improves diabetic endothelial dysfunction via activation of SIRT1.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Toxicology and Nutrition, School of Public Health, Shandong University, Jinan, Shandong, China.

Endothelial dysfunction contributes to diabetic macrovascular complications, resulting in high mortality. Recent findings demonstrate a pathogenic role of P53 in endothelial dysfunction, encouraging the investigation of the effect of P53 inhibition on diabetic endothelial dysfunction. Thus, high glucose (HG)-treated endothelial cells (ECs) were subjected to pifithrin-α (PFT-α)-a specific inhibitor of P53, or P53-small interfering RNA (siRNA), both of which attenuated the HG-induced endothelial inflammation and oxidative stress. Read More

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http://dx.doi.org/10.1111/jcmm.14253DOI Listing
February 2019

EED and EZH2 constitutive variants: A study to expand the Cohen-Gibson syndrome phenotype and contrast it with Weaver syndrome.

Am J Med Genet A 2019 Feb 21. Epub 2019 Feb 21.

Department of Clinical Genetics, St George's University of London, London, United Kingdom.

Overgrowth-intellectual disability (OGID) syndromes are characterized by increased growth (height and/or head circumference ≥+2 SD) in association with an intellectual disability. Constitutive EED variants have previously been reported in five individuals with an OGID syndrome, eponymously designated Cohen-Gibson syndrome and resembling Weaver syndrome. Here, we report three additional individuals with constitutive EED variants, identified through exome sequencing of an OGID patient series. Read More

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http://dx.doi.org/10.1002/ajmg.a.61066DOI Listing
February 2019

Safety and efficacy of tirofiban combined with endovascular treatment in acute ischemic stroke.

Eur J Neurol 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China.

Background: Tirofiban is off-label used in clinical practice for acute ischemic stroke (AIS). However, whether tirofiban increases the bleeding risk or improves the outcome of endovascular treatment (EVT) in AIS is unknown. This study evaluated the efficacy and safety of tirofiban in combination with EVT for AIS. Read More

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http://dx.doi.org/10.1111/ene.13946DOI Listing
February 2019

Oxidative Lipoprotein Markers Predict Poor Functional Outcome in Patients with Minor Stroke or Transient Ischemic Attack.

Eur J Neurol 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background And Purpose: Oxidative stress plays an important role in acute ischemic stroke. However, the association of oxidative lipoprotein markers, including oxidized low-density lipoprotein (oxLDL), oxLDL/ high density lipoprotein (HDL), and oxLDL/ low density lipoprotein (LDL), with functional outcome of minor stroke or transient ischemic attack (TIA) remains unclear. We aimed to investigate the association between oxidative lipoprotein markers and poor functional outcome in patients with minor stroke or TIA. Read More

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http://dx.doi.org/10.1111/ene.13943DOI Listing
February 2019

Clinical, neuroimaging and prognostic study of 127 cases with infarction of the corpus callosum.

Eur J Neurol 2019 Feb 21. Epub 2019 Feb 21.

Deparment of Neurology, Changhai Hospital, 168 Changhai Road, 200433, Shanghai, P.R. China.

Background And Purpose: To investigate retrospectively clinical and neuroimaging characteristics in the largest sample size of patients with corpus callosum infarction up to now, and then follow up for 1year to obtain the prognosis of this rare stroke entity.

Methods: 127 patients with acute callosal infarction of 5584 patients with acute ischemic stroke were included in this study. The recruited patients were divided into pure callosal infarction group and complex callosal infarction group (coupled with other infarct locations simultaneously) and clinical and neuroimaging features were analyzed. Read More

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http://dx.doi.org/10.1111/ene.13942DOI Listing
February 2019

IV thrombolysis in stroke mimics - Results from the SITS International Stroke Thrombolysis Register (SITS-ISTR).

Eur J Neurol 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurology, Karolinska University Hospital and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm.

Background And Purpose: Patients with stroke mimics, conditions with stroke-like symptoms, may risk harm if treated with intravenous thrombolysis (IVT). Current guidelines state low risk of intracranial hemorrhage (ICH) based on studies comprising a total of <400 stroke mimic cases. We aimed to compare safety and outcomes following IVT between patients with acute ischemic stroke and mimicking conditions. Read More

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http://dx.doi.org/10.1111/ene.13944DOI Listing
February 2019

Clinical applicability of diagnostic biomarkers in early onset cognitive impairment.

Eur J Neurol 2019 Feb 21. Epub 2019 Feb 21.

Alzheimer's disease and other cognitive disorders Unit. Service of Neurology, Hospital Clínic de Barcelona, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: Several diagnostic biomarkers are currently available for its clinical use in early onset cognitive impairment. The decision of which biomarker is used in each patient depends on several factors such as its predictive value or tolerability.

Methods: Forty subjects with early onset cognitive complaints (<65 years): 26 with Alzheimer's disease (AD), 5 with fronto-temporal dementia and 9 with non-neurodegenerative disorder diagnostic suspicion. Read More

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http://dx.doi.org/10.1111/ene.13945DOI Listing
February 2019

The minimum clinically important difference (MCID): which direction to take.

Eur J Neurol 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurology, Maastricht University Medical Centre+, Maastricht, the Netherlands.

Over the past decades in modern medicine, there has been a shift from statistical significance to clinical relevance when it comes to interpreting results from clinical trials. A concept that is increasingly being used as a surrogate for clinical relevance and effect size calculation is the minimum clinically important difference (MCID). In this paper, we will present an overview of the most important aspects of the MCID concept used in research trials and we will discuss what this means for the neurological patient in clinical trials and daily practice. Read More

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http://dx.doi.org/10.1111/ene.13941DOI Listing
February 2019

Susceptibility-weighted imaging in malignant melanoma brain metastasis.

J Magn Reson Imaging 2019 Feb 21. Epub 2019 Feb 21.

Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.

Background: The value of cerebral susceptibility-weighted imaging (SWI) in malignant melanoma (MM) patients remains controversial and the effect of melanin on SWI is not well understood.

Purpose: To systematically analyze the spectrum of intracerebral findings in MM brain metastases (BM) on SWI and to determine the diagnostic value of SWI.

Study Type: Retrospective. Read More

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http://dx.doi.org/10.1002/jmri.26692DOI Listing
February 2019

Network abnormalities among non-manifesting Parkinson disease related LRRK2 mutation carriers.

Hum Brain Mapp 2019 Feb 21. Epub 2019 Feb 21.

Sagol Brain Institute Tel-Aviv Medical Center, Tel-Aviv, Israel.

Non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene represent an "at risk" group for future development of Parkinson's disease (PD) and have demonstrated task related fMRI changes. However, resting-state networks have received less research focus, thus this study aimed to assess the integrity of the motor, default mode (DMN), salience (SAL), and dorsal attention (DAN) networks among this unique population by using two different connectivity measures: interregional functional connectivity analysis and Dependency network analysis (D NA). Machine learning classification methods were used to distinguish connectivity between the two groups of participants. Read More

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http://dx.doi.org/10.1002/hbm.24543DOI Listing
February 2019

Cerebrospinal fluids from Alzheimer's disease patients exhibit neurotoxic effects on neuronal cell cultures.

Eur J Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Neuroscience Institute, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50161, Kaunas, Lithuania.

A growing number of studies suggest amyloid-β and tau present in cerebrospinal fluid (CSF) and blood as putative biomarkers for Alzheimer's disease (AD). However, there is a question whether these compounds present in patients' bodily fluids can directly cause neurotoxic effects. We investigated effects of AD and other dementia (OD) patients' blood serum and CSF on viability of cells in primary cerebellar granule cell cultures. Read More

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http://dx.doi.org/10.1111/ejn.14389DOI Listing
February 2019

Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells.

Glia 2019 Apr 28;67(4):718-728. Epub 2018 Nov 28.

Neuroprotection Research Laboratory, Department of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.

During development or after brain injury, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes to supplement the number of oligodendrocytes. Although mechanisms of OPC differentiation have been extensively examined, the role of epigenetic regulators, such as histone deacetylases (HDACs) and DNA methyltransferase enzymes (DNMTs), in this process is still mostly unknown. Here, we report the differential roles of epigenetic regulators in OPC differentiation. Read More

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http://dx.doi.org/10.1002/glia.23567DOI Listing

Splenic arterial injury caused by use of a lumen-apposing metal stent for walled-off pancreatic necrosis drainage.

Dig Endosc 2019 Feb 21. Epub 2019 Feb 21.

Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa, 761-0793, Japan.

Walled-off pancreatic necrosis (WON) is a severe complication of acute necrotizing pancreatitis with pancreatic fluid collection. Endoscopic ultrasound (EUS)-guided drainage has been proposed as first-line treatment for WON. A newly developed lumen-apposing metal stent (LAMS) was recently introduced for WON drainage. Read More

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http://dx.doi.org/10.1111/den.13376DOI Listing
February 2019

The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy.

J Inherit Metab Dis 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatric Neurology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Introduction: Currently, no therapies are available for Zellweger spectrum disorders (ZSDs), a group of genetic metabolic disorders characterised by a deficiency of functional peroxisomes. In a previous study, we showed that oral cholic acid (CA) treatment can suppress bile acid synthesis in ZSD patients and, thereby, decrease plasma levels of toxic C -bile acid intermediates, one of the biochemical abnormalities in these patients. However, no effect on clinically relevant outcome measures could be observed after 9 months of CA treatment. Read More

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http://doi.wiley.com/10.1002/jimd.12042
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http://dx.doi.org/10.1002/jimd.12042DOI Listing
February 2019
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An update on the genetics, clinical presentation, and pathomechanisms of human riboflavin transporter deficiency.

J Inherit Metab Dis 2019 Jan 12. Epub 2019 Jan 12.

MRC Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

Riboflavin transporter deficiency (RTD) is a rare neurological condition that encompasses the Brown-Vialetto-Van Laere and Fazio-Londe syndromes since the discovery of pathogenic mutations in the SLC52A2 and SLC52A3 genes that encode human riboflavin transporters RFVT2 and RFVT3. Patients present with a deteriorating progression of peripheral and cranial neuropathy that causes muscle weakness, vision loss, deafness, sensory ataxia, and respiratory compromise which when left untreated can be fatal. Considerable progress in the clinical and genetic diagnosis of RTDs has been made in recent years and has permitted the successful lifesaving treatment of many patients with high dose riboflavin supplementation. Read More

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http://dx.doi.org/10.1002/jimd.12053DOI Listing
January 2019

MUL1 Gene Polymorphisms And Parkinson's Disease Risk.

Acta Neurol Scand 2019 Feb 22. Epub 2019 Feb 22.

Neurology Department of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, PR China.

Objectives: Parkinson's disease (PD) is afflicting millions of patients worldwide, and gene therapy may be a hope for cure. Recent researches have shown that MUL1 may play a key role in PD pathogenesis, but no specific genetic variants has been identified. This study was aimed to verify the hypothesis that variants in MUL1 gene were associated with PD risk in a Chinese cohort. Read More

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http://dx.doi.org/10.1111/ane.13081DOI Listing
February 2019

Authors' Reply to Rana et al. "Efficacy and Safety of Intravenous Tenecteplase Bolus in Acute Ischemic Stroke: Results of Two Open-Label, Multicenter Trials".

Am J Cardiovasc Drugs 2019 Feb 22. Epub 2019 Feb 22.

K.G. Hospital and Post Graduate Institute, Coimbatore, Tamil Nadu, 641018, India.

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http://dx.doi.org/10.1007/s40256-019-00334-8DOI Listing
February 2019

Management of De Novo Carotid Stenosis and Postintervention Restenosis-Carotid Endarterectomy Versus Carotid Artery Stenting-a Review of Literature.

Transl Stroke Res 2019 Feb 22. Epub 2019 Feb 22.

Department of Neurological Surgery, University of South Florida, 2 Tampa General Circle, Tampa, FL, 33606, USA.

The current literature indicates carotid endarterectomy (CEA) as the preferred treatment for symptomatic, moderate to severe carotid artery stenosis. However, recommendations for the management of acute tandem stenosis and complete occlusion, as well as postintervention restenosis of the carotid artery, remain controversial. Here, we review the literature evaluating these conditions and provide suggestions for clinical decision-making. Read More

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http://dx.doi.org/10.1007/s12975-019-00693-zDOI Listing
February 2019

Erenumab for Preventive Treatment of Migraine: A Systematic Review and Meta-Analysis of Efficacy and Safety.

Drugs 2019 Feb 22. Epub 2019 Feb 22.

Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Via Conca 71, 60020, Ancona, Italy.

Background: Novel therapeutic options with improved efficacy and safety profiles are needed for the prophylaxis of migraine. In recent years, the inhibition of calcitonin gene-related peptide (CGRP) signaling has attracted growing interest in the pharmacological research on migraine. Erenumab is the first fully human monoclonal antibody directed against the CGRP receptor to be approved for use in migraineurs. Read More

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http://dx.doi.org/10.1007/s40265-019-01069-1DOI Listing
February 2019

An Active Duty Sailor With Worsening Headaches and Blurry Vision.

Mil Med 2019 Feb 22. Epub 2019 Feb 22.

Optometry, Branch Health Clinic Naval Station Norfolk, 1721 Admiral Taussig Blvd, Norfolk, VA.

Headaches are a typical presentation to a military medical department or emergency room. Having a broad differential diagnosis and utilizing a thorough physical exam can assist providers in honing down the list of pathology and in identifying potentially life-threatening causes of cephalgia such as intracranial tumors. In this case, a 27-year-old man presented with progressive headaches along with vision changes for the preceding 2-3 months. Read More

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http://dx.doi.org/10.1093/milmed/usy401DOI Listing
February 2019

Smartphone problem-solving therapy to reduce fear of cancer recurrence among breast cancer survivors: an open single-arm pilot study.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Division of Psycho-Oncology and Palliative Care, Nagoya City University Hospital, Mizuho-cho, Mizuho-ku, Nagoya, Japan.

Objectives: The purpose of this study was to investigate a newly developed smartphone problem-solving therapy (PST) application's feasibility and preliminary effectiveness for reducing fear of cancer recurrence (FCR) among breast cancer survivors.

Methods: Female disease-free breast cancer survivors aged 20-49 years who were more than 6 months post-breast surgery participated in the study. The patients received the smartphone PST using an iPhone or iPad for 8 weeks. Read More

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http://dx.doi.org/10.1093/jjco/hyz005DOI Listing
February 2019