398,163 results match your criteria Neurology Reviews[Journal]


Encephalopathy in neonates with subgaleal hemorrhage is a key predictor of outcome.

Pediatr Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Objective: Subgaleal hemorrhage (SGH) is reported to be associated with severe hemodynamic instability, coagulopathy, and even mortality. The importance of the presence or absence of neonatal encephalopathy in predicting SGH outcomes has not been explored. The aim of this study was to determine the relationship of clinical encephalopathy to short-term outcomes in neonates with SGH. Read More

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http://dx.doi.org/10.1038/s41390-019-0400-1DOI Listing

Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing

History of dietary treatment: Guelpa & Marie first report of intermittent fasting for epilepsy in 1911.

Epilepsy Behav 2019 Apr 15;94:277-280. Epub 2019 Apr 15.

Expert Centre for Rare Epilepsies, Department of Pediatric Neurology, CHU Hôpital Robert-Debré, APHP, Paris, France. Electronic address:

We analyzed the article of Guelpa & Marie, published in 1911 and often quoted in the history of dietary treatment, as the basis for the use of ketogenic diet to mimic fasting. In this paper, the authors treated 21 patients with a diet consisting of daily administration of 30 g of sodium sulphate for 4 days, with unlimited aqueous beverage and no food, followed by a vegetarian diet restricted to half of the ordinary intake. This is the first report of intermittent fasting as treatment strategy for epilepsy. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.018DOI Listing

Unverricht-Lundborg disease: Clinical course and seizure management based on the experience of polish centers.

Authors:
Anetta Lasek-Bal

Seizure 2019 Apr 10;69:87-91. Epub 2019 Apr 10.

Department of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635, Katowice, Poland. Electronic address:

The purpose of this paper was to present our experience following the longterm treatment of 11 patients with Unverricht-Lundborg disease (ULD) confirmed by molecular testing.

Methods: We analyzed the clinical course, cognitive state, neuroimaging and neurophysiology results.

Results: The data were collected from 9 unrelated families (F/M: 4/7) aged 25-49. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.04.008DOI Listing

Principles of progenitor temporal patterning in the developing invertebrate and vertebrate nervous system.

Curr Opin Neurobiol 2019 Apr 15;56:185-193. Epub 2019 Apr 15.

Department of Basic Neurosciences, University of Geneva, Switzerland; Department of Neurology, Geneva University Hospital, Geneva, Switzerland. Electronic address:

During the development of the central nervous system, progenitors successively generate distinct types of neurons which assemble into the circuits that underlie our ability to interact with the environment. Spatial and temporal patterning mechanisms are partially evolutionarily conserved processes that allow generation of neuronal diversity from a limited set of progenitors. Here, we review examples of temporal patterning in neuronal progenitors in the Drosophila ventral nerve cord and in the mammalian cerebral cortex. Read More

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http://dx.doi.org/10.1016/j.conb.2019.03.004DOI Listing

A SCA7 premutation may be a novel Mendelian modifier of MS course: A case report.

Mult Scler Relat Disord 2019 Apr 13;31:148-150. Epub 2019 Apr 13.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

A proportion of patients with the phenotype of complex genetic disorders carry dominantly inherited Mendelian traits, exemplified by hereditary spastic paraparesis influencing pyramidal symptoms in some MS cases. We here describe a mutable ATXN7 gene, a SCA7 premutation, in a patient fulfilling contemporary definitions of primary progressive MS. His onset age, and onset with a severely progressive cerebellar ataxia syndrome, was outside the reported range of symptoms in a representative MS material. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348193016
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http://dx.doi.org/10.1016/j.msard.2019.04.009DOI Listing
April 2019
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Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test.

Arch Gerontol Geriatr 2019 Apr 1;83:114-120. Epub 2019 Apr 1.

Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University of Madrid, Spain.

Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674943193008
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http://dx.doi.org/10.1016/j.archger.2019.03.025DOI Listing
April 2019
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Intravenous Infusion of Mesenchymal Stem Cells Improves Impaired Cognitive Function in a Cerebral Small Vessel Disease Model.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan; Department of Neurology, Yale University School of Medicine, New Haven, CT, 06510, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

Cerebral small vessel disease (CSVD) is not only a cause of vascular dementia (VD) but also a contributing factor to Alzheimer's disease (AD). The essential pathological feature of CSVD is the disruption of blood-brain barrier (BBB). Dysfunction of BBB due to degeneration of both endothelial cells and pericytes in capillaries leads to neuronal damage and progressive brain atrophy. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.018DOI Listing

Physical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa.

Behav Brain Res 2019 Apr 15:111915. Epub 2019 Apr 15.

Department of Neurology, Charité-Universitätsmedizin, Charitéplatz 1, 10117, Berlin, Germany. Electronic address:

The neurodegenerative disorder Parkinson's disease affects motor abilities as well as cognition. The gold standard therapy is L-Dopa, which mainly restores motor skills. Therefore, we require additional interventions to sustain cognitive functions in Parkinson's disease. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111915DOI Listing

Prioritized Brain Selenium Retention and Selenoprotein Expression: Nutritional Insights into Parkinson's Disease.

Mech Ageing Dev 2019 Apr 15. Epub 2019 Apr 15.

Department of Geriatrics and Neurology, the Second Affiliated Hospital and Yuying Children's Hospital, China; Department of Preventive Medicine, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Selenium (Se), an essential trace mineral, confers its physiological functions mainly through selenoproteins, most of which are oxidoreductases. Results from animal, epidemiological, and human genetic studies link Parkinson's disease to Se and certain selenoproteins. Parkinson's disease is characterized by multiple motor and non-motor symptoms that are difficult to diagnose at early stages of the pathogenesis. Read More

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http://dx.doi.org/10.1016/j.mad.2019.04.004DOI Listing

Untangling Narcolepsy and Diabetes: Pathomechanisms with Eyes on Therapeutic Options.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Student's Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran; NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Narcolepsy (NA) is a primary sleep disorder characterized by loss of hypocretinergic/orexinergic neurons. NA is associated with an increased risk for metabolic disorders such as diabetes mellitus (DM). Proposed mechanisms for this association are alterations in food intake, disruption of energy balance, glucose tolerance, and insulin sensitivity, as well as inflammation and genetic factors. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.013DOI Listing

Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Anatomy & Neurobiology, 72 E. Concord Street, L-1004, Boston University School of Medicine, Boston, MA 02118 USA; Department of Neurology, 72 E. Concord Street, C3, Boston University School of Medicine, Boston, MA 02118 USA.

Cortical injury elicits long-term cytotoxic and cytoprotective mechanisms within the brain and the balance of these pathways can determine the functional outcome for the individual. Cytotoxicity is exacerbated by production of reactive oxygen species, accumulation of iron, and peroxidation of cell membranes and myelin. There are currently no neurorestorative treatments to aid in balancing the cytotoxic and cytoprotective mechanisms following cortical injury. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.015DOI Listing

Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Neuroradiology, University Medical Center Freiburg, Germany.

Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 age-matched controls were examined with transcranial Doppler. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193020
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http://dx.doi.org/10.1016/j.brainres.2019.04.014DOI Listing
April 2019
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Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers.

Clin Biochem 2019 Apr 15. Epub 2019 Apr 15.

Centre for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.011DOI Listing

Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions.

Neuron 2019 Apr;102(2):294-320

Department of Neurology, The Sean M. Healey and AMG Center for ALS at Mass General, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA. Electronic address:

RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of RNA binding proteins and widespread RNA processing defects are increasingly recognized as critical determinants of neurological diseases. Read More

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http://dx.doi.org/10.1016/j.neuron.2019.03.014DOI Listing

A Retrospective Study Investigating: Factors associated with mode of arrival and emergency department management for patients with acute stroke.

Australas Emerg Care 2018 Aug 17;21(3):99-104. Epub 2018 Aug 17.

University of Melbourne, Department of Medicine, Australia; Royal Melbourne Hospital, Emergency Department, Australia. Electronic address:

Background: Presentation by ambulance to the emergency department is critical for stroke patients to receive time dependent treatments. However, little is known of the factors that influence presentation by ambulance.

Methods: Retrospective analysis of all patients with an emergency department medical diagnosis of stroke who presented to one of three Victorian emergency departments over a three-year period (2011-2013). Read More

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http://dx.doi.org/10.1016/j.auec.2018.07.001DOI Listing

Therapeutic Window for Phosphodiesterase 6-Related Retinitis Pigmentosa.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology and Pathology and Cell Biology, Columbia Stem Cell Initiative, Institute of Human Nutrition, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.6381DOI Listing

Mediating effect of mindfulness cognition on the development of empathy in a university context.

PLoS One 2019 18;14(4):e0215569. Epub 2019 Apr 18.

Department of Science Education, University of Burgos, Castile and León, Spain.

Numerous interventions propose mindfulness training as a means of improving empathy. Our aim is to analyse the relationship between mindfulness practice and empathy through the mediating process of trait mindfulness. This sample comprised 264 undergraduate students ([Formula: see text], SD = 11,39). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215569PLOS

Strategies of selective changing: Preparatory neural processes seem to be responsible for differences in complex inhibition.

PLoS One 2019 18;14(4):e0214652. Epub 2019 Apr 18.

Institute of Medical Psychology and Medical Sociology, University Hospital of RWTH Aachen University, Aachen, Germany.

Selective inhibition describes the stopping of an action while other actions are further executed. It can be differentiated between two strategies to stop selectively: the fast but global stop all, then discriminate strategy and the slower but more selective first discriminate, then stop strategy. It is assumed that the first discriminate, then stop strategy is especially used when information regarding which action might have to be stopped is already available beforehand. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214652PLOS

Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients.

PLoS One 2019 18;14(4):e0214733. Epub 2019 Apr 18.

Department of Clinical Pharmacology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.

The study aims to clarify the mechanism in patients with neurally mediated syncope (NMS), focusing on the adenylate cyclase (AC) activity level in lymphocytes. This study included 40 subjects: 22 healthy volunteers and 18 NMS patients. We investigated the changes in AC activity that occur during of syncope at rest and during the head-up tilt (HUT) test. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214733PLOS

Barriers and facilitators of communication about off periods in Parkinson's disease: Qualitative analysis of patient, carepartner, and physician Interviews.

PLoS One 2019 18;14(4):e0215384. Epub 2019 Apr 18.

Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, Toronto, Ontario, Canada.

Background: Successful patient-physician communication is critical for improving health outcomes, but research regarding optimal communication practices in Parkinson's disease is limited. The objective of the current study was to investigate barriers and facilitators of communication between persons with Parkinson's disease, carepartners, and physicians, specifically in the setting of off periods, with the goal of identifying ways to improve patient-carepartner-physician communication.

Method: We interviewed persons with Parkinson's, carepartners, and physicians (specialists and non-specialists) using a semi-structured questionnaire to identify and describe experiences, barriers, and facilitators relating to communication about off periods in Parkinson's disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215384PLOS

SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species.

PLoS Comput Biol 2019 Apr 18;15(4):e1006968. Epub 2019 Apr 18.

Department of Computer Science, ETH Zurich, Zürich, Switzerland.

Understanding sleep and its perturbation by environment, mutation, or medication remains a central problem in biomedical research. Its examination in animal models rests on brain state analysis via classification of electroencephalographic (EEG) signatures. Traditionally, these states are classified by trained human experts by visual inspection of raw EEG recordings, which is a laborious task prone to inter-individual variability. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006968DOI Listing

Dual diagnosis causing severe phenotype in a patient with Angelman syndrome.

Clin Dysmorphol 2019 Apr 15. Epub 2019 Apr 15.

Sheffield Clinical Genetics Service.

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http://dx.doi.org/10.1097/MCD.0000000000000280DOI Listing

'Likelihood to be diagnosed or misdiagnosed': application to meta-analytic data for cognitive screening instruments.

Neurodegener Dis Manag 2019 Apr 18. Epub 2019 Apr 18.

Cognitive Function Clinic, Walton Center for Neurology & Neurosurgery, Liverpool, UK.

To extend use of the recently described 'likelihood to be diagnosed or misdiagnosed' (LDM) metric for test accuracy studies through application to recent meta-analytic data of commonly used cognitive screening instruments. Raw data (true positives and negatives, false positives and negatives) were extracted from meta-analyses (minimum 5 studies or 1000 patients), from which LDM was calculated. LDM values were compared with those previously reported for single test accuracy studies. Read More

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http://dx.doi.org/10.2217/nmt-2018-0041DOI Listing

Usability of a daily mHealth application designed to address mobility, speech and dexterity in Parkinson's disease.

Neurodegener Dis Manag 2019 Apr 18. Epub 2019 Apr 18.

Program in Physical Therapy, Washington University School of Medicine, St Louis, MO, USA.

This study investigated the usability of a mobile health (mHealth) smartphone application to treat gait, speech and dexterity in people with Parkinson's disease. Participants either used an mHealth application (intervention) or maintained their normal routine (control) for 12 weeks and were evaluated at baseline and post-test time points for primary outcome measures of adherence, gait, speech and dexterity. mHealth application adherence was compared with percent change scores on gait, speech and dexterity measures. Read More

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http://dx.doi.org/10.2217/nmt-2018-0036DOI Listing

Prevalence and ethnic pattern of overweight and obesity among middle-aged and elderly adults in China.

Eur J Prev Cardiol 2019 Apr 18:2047487319845129. Epub 2019 Apr 18.

1 Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China.

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http://dx.doi.org/10.1177/2047487319845129DOI Listing

Associations of intercellular adhesion molecule-1 rs5498 polymorphism with ischemic stroke: A meta-analysis.

Mol Genet Genomic Med 2019 Apr 17:e643. Epub 2019 Apr 17.

Department of General Practice, Shanghai Pudong New District Dongming Community Healthcare Center, Shanghai, China.

Background: Recently, associations between intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and ischemic stroke (IS) were investigated by several pilot studies, but with inconsistent results. In this study, a meta-analysis was performed to better assess the relationship between ICAM-1rs5498 polymorphism and IS.

Methods: PubMed, Medline, Embase, and CNKI were searched for eligible studies. Read More

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http://dx.doi.org/10.1002/mgg3.643DOI Listing

Senescence as a main mechanism of Ritonavir and Ritonavir-NO action against melanoma.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Department of Immunology, Institute for Biological Research "Siniša Stanković", Belgrade University, Belgrade, Serbia.

The main focus of this study is exploring the effect and mechanism of two HIV-protease inhibitors: Ritonavir and Ritonavir-nitric oxide (Ritonavir-NO) on in vitro growth of melanoma cell lines. NO modification significantly improved the antitumor potential of Ritonavir, as the IC values of Ritonavir-NO were approximately two times lower than IC values of the parental compound. Our results showed for the first time, that both compounds induced senescence in primary and metastatic melanoma cell lines. Read More

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http://dx.doi.org/10.1002/mc.23020DOI Listing

Rap2B promotes cell adhesion, proliferation, migration and invasion of human glioma.

J Neurooncol 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, 99 Huaihai Road West, Xuzhou, 221002, Jiangsu, People's Republic of China.

Purpose: Rap2B, a member of the GTP-binding proteins, is generally up-regulated in numerous types of tumors. Nevertheless, the influence and regulatory mechanisms of Rap2B in gliomas are still not corroborated. Therefore, we analyzed the expression of Rap2B in glioma tissues and cells, and researched its significance in adhesion, proliferation, migration and invasion of the glioma cell line. Read More

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http://dx.doi.org/10.1007/s11060-019-03163-6DOI Listing

Tonic pupils: an unusual autonomic involvement in chronic inflammatory demyelinating polyneuropathy (CIDP).

Neurol Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, São Paulo, SP, 04039-002, Brazil.

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neuropathy which affects mainly large myelinated axons and has a typically mild autonomic dysfunction mainly from postganglionic nerve fiber involvement.

Case Report: We report here an acute onset CIDP initially diagnosed as Guillain-Barré syndrome (GBS), unresponsive to treatment with intravenous immunoglobulin (IVIg), which later responded to plasmapheresis and corticoids. The patient had a markedly distal demyelination, prominent cranial nerve involvement and, interestingly, bilateral fixed dilated pupils. Read More

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http://dx.doi.org/10.1007/s10072-019-03890-8DOI Listing

Exploring hyperhidrosis and related thermoregulatory symptoms as a possible clinical identifier for the dysautonomic subtype of Parkinson's disease.

J Neurol 2019 Apr 17. Epub 2019 Apr 17.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neurosciences, De Crespigny Park, London, SE5 8AF, UK.

Objective: To identify associated (non-)motor profiles of Parkinson's disease (PD) patients with hyperhidrosis as a dominant problem.

Methods: This is a cross-sectional, exploratory, analysis of participants enrolled in the Non-motor Longitudinal International Study (NILS; UKCRN No: 10084) at the Parkinson's Centre at King's College Hospital (London, UK). Hyperhidrosis scores (yes/no) on question 28 of the Non-Motor Symptom Questionnaire were used to classify patients with normal sweat function (n = 172) and excessive sweating (n = 56) (Analysis 1; n = 228). Read More

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http://dx.doi.org/10.1007/s00415-019-09325-wDOI Listing

Electrophysiologic evaluation of facial nerve functions after oxaliplatin treatment.

Cancer Chemother Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Audiology, Faculty of Health Sciences, Medipol University, Istanbul, Turkey.

Purpose: This study analyzes the effect of oxaliplatin treatment on the facial nerve. The facial nerve is the most commonly paralyzed cranial motor nerve because it advances through a long, curved bone canal. Electroneurography and blink reflex are the electrophysiological measurements used for evaluating facial nerve function. Read More

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http://dx.doi.org/10.1007/s00280-019-03841-2DOI Listing

A Rare but Disabling Stroke.

Ann Acad Med Singapore 2019 Mar;48(3):109-111

Division of Neurology, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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Behavioural and Psychological Symptoms in Neurocognitive Disorders: Specific Patterns in Dementia Subtypes.

Open Med (Wars) 2019 4;14:307-316. Epub 2019 Apr 4.

Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.

Background: Behavioural and psychological symptoms in dementia (BPSD) form an important sub-syndrome of dementia. We assessed the frequency and severity of BPSD in a random sample of Hungarian treatment-naïve dementia patients. Furthermore, we examined the relationship between cognitive symptoms and BPSD and the pattern of BPSD in specific types of dementias. Read More

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http://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019
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http://dx.doi.org/10.1515/med-2019-0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463819PMC
April 2019
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The obesity paradox in lung cancer: is there a missing biological link?

J Thorac Dis 2019 Mar;11(Suppl 3):S363-S366

Neurology Laboratory, Medical School, University of Crete, Heraklion, Greece.

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http://dx.doi.org/10.21037/jtd.2018.12.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424778PMC

Low frequency of pre-treatment and post-treatment haematological abnormalities in dogs with non-infectious meningoencephalitis treated with cytosine arabinoside and prednisolone.

Vet Rec Open 2019 27;6(1):e000315. Epub 2019 Feb 27.

Department of Neurology, Langford Veterinary Services, Langford, UK.

Background: Cytosine arabinoside (CA) and prednisolone are drugs commonly used together in the management of canine non-infectious meningoencephalitis (NIME). The aim of this study was to report the haematological findings before and after CA and prednisolone treatment and identify any adverse haematological events in this clinical setting, following the veterinary cooperative oncology group established common terminology criteria for recording adverse events following administration of chemotherapy or biological antineoplastic therapy.

Results: While 48 patients with a presumptive diagnosis of NIME had pretreatment haematology results, only 12 patients met the inclusion criteria of also having post-treatment haematology results available for review after being treated with prednisolone and CA at a standard dose (200 mg/m) in a single referral hospital in the UK. Read More

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http://dx.doi.org/10.1136/vetreco-2018-000315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446212PMC
February 2019

Utility of transoral pharyngeal ultrasonography for puncture drainage of peritonsillar abscess.

Clin Case Rep 2019 Apr 19;7(4):839-840. Epub 2019 Feb 19.

Department of Neurology St. Marianna University School of Medicine Kawasaki Japan.

Puncture drainage is usually needed to treat peritonsillar abscess. However, inadvertent carotid artery puncture may result in devastating complications. Preoperative transoral carotid ultrasonography (TOCU) is useful to delineate the anatomical relationship between the abscess and carotid artery. Read More

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http://dx.doi.org/10.1002/ccr3.2032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452502PMC

Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review.

Clin Case Rep 2019 Apr 19;7(4):638-643. Epub 2019 Feb 19.

Department of Neurology, EMG and Neuropathic Pain Unit Hospital Clínic Barcelona Spain.

Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination. The absence of lumbosacral F waves motor responses without demyelinating findings may indicate early direct root toxicity. Early electromyography (EMG) screening could be a valuable tool for detecting peripheral neurotoxicity. Read More

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http://dx.doi.org/10.1002/ccr3.2026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452470PMC

Developmental delay, coarse facial features, and epilepsy in a patient with gene variants.

Clin Case Rep 2019 Apr 19;7(4):632-637. Epub 2019 Feb 19.

Department of Clinical Genomics Mayo Clinic Rochester Minnesota.

We report a patient with developmental delay, autism, epilepsy, macrocephaly, facial dysmorphism, gastrointestinal, and behavioral issues due to compound heterozygous likely pathogenic variants. This case report expands the gene mutation database and the clinical spectrum of patients with deficiencies in the heparan sulfate pathway. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2010
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http://dx.doi.org/10.1002/ccr3.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452521PMC
April 2019
1 Read

Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody.

Neurol Int 2019 Mar 11;11(1):7958. Epub 2019 Mar 11.

Department of Neurology.

Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren's syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. Read More

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http://dx.doi.org/10.4081/ni.2019.7958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444563PMC

Large left posterior fossa meningioma presenting with quadriplegia in a woman with history of carbidopa-levodopa resistant parkinsonism.

Neurol Int 2019 Mar 11;11(1):7815. Epub 2019 Mar 11.

Radiology Unit, Surgi-Med Clinic.

A 56-year-old Afro-Trinidadian woman with a history of a carbidopa-levodopa resistance Parkinsonian-like syndrome for 2 years, presented with acute onset spastic quadriplegia and decreased responsiveness. Diagnosis involved clinical and MR-imaging correlation consistent with a large left posterior fossa meningioma. Surgical removal of the tumor led to complete reversibility of the neurological manifestations associated with cerebellar tonsillar herniation beyond the foramen magnum and mass effect on the brainstem, cerebellum and midbrain regions. Read More

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http://dx.doi.org/10.4081/ni.2019.7815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444560PMC

Transcranial motor-evoked potentials for prediction of postoperative neurologic and motor deficit following surgery for thoracolumbar scoliosis.

Orthop Rev (Pavia) 2019 Feb 12;11(1):7757. Epub 2019 Mar 12.

Department of Orthopedic Surgery, Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI, USA.

Transcranial motor-evoked potentials (TcMEPs) are used to monitor the descending motor pathway during scoliosis surgery. By comparing potentials before and after correction, surgeons may prevent postoperative functional loss in distal muscles. There is currently no consensus as to which muscles should be monitored. Read More

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https://www.pagepress.org/journals/index.php/or/article/view
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http://dx.doi.org/10.4081/or.2019.7757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452093PMC
February 2019
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Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease.

ACS Med Chem Lett 2019 Apr 8;10(4):621-626. Epub 2019 Feb 8.

Department of Chemistry "Ugo Schiff", University of Firenze, via della Lastruccia n. 3-13, 50019 Sesto Fiorentino (FI), Italy.

Pharmacological chaperones (PCs) are small molecules that bind and stabilize enzymes. They can rescue the enzymatic activity of misfolded or deficient enzymes when they are used at subinhibitory concentration, thus with minimal side effects. Pharmacological Chaperone Therapy (PCT) is an emerging treatment for many lysosomal storage disorders (LSDs) including Gaucher disease, the most common, which is characterized by a deficiency in the GCase enzyme. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467014PMC

Comparison of gait with and without ankle-foot orthoses after lower limb surgery in children with unilateral cerebral palsy.

J Child Orthop 2019 Apr;13(2):180-189

Medical Faculty, Department of Interdisciplinary Health Science, University of Oslo, Oslo, Norway.

Purpose: Children with spastic unilateral cerebral palsy (SUCP) frequently undergo lower limb surgery to improve gait. Postoperatively, ankle-foot orthoses (AFOs) are used to maintain the surgical corrections and provide adequate mechanical support. Our aim was to evaluate changes in gait and impacts of AFOs one-year postoperatively. Read More

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http://dx.doi.org/10.1302/1863-2548.13.180146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442508PMC

PANDAS/PANS in childhood: Controversies and evidence.

Paediatr Child Health 2019 May 9;24(2):85-91. Epub 2018 Dec 9.

Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Since first defined in 1998, paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and its later, broader iteration, paediatric acute-onset neuropsychiatric syndrome (PANS), have garnered significant attention and controversy. The role of streptococcal infection in children with explosive onset obsessive-compulsive disorder and new onset tics, the natural history of this entity, and the role of symptomatic and disease-modifying therapies, including antibiotics, immunotherapy, and psychoactive drugs, are all issues that have yet to be definitively addressed. While definitive proof of the autoimmune hypothesis of PANDAS is lacking, given the heightened attention to this entity and apparent rise in use of this diagnostic category, addressing questions around diagnosis, treatment, and etiology is imperative. Read More

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https://academic.oup.com/pch/article/24/2/85/5236858
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http://dx.doi.org/10.1093/pch/pxy145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462125PMC
May 2019
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[Clinical features of long segmental myelopathy caused by nitrous oxide].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):288-292

Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China.

Objective: To analyze the clinical and imaging characteristics of the neurological damage caused by nitrous oxide (NO).

Methods: In the study, 10 patients in the Department of Neurology of China-Japan Friendship Hospital from October 2015 to February 2018 were retrospectively analyzed for the demographic data, the history of inhaled NO, clinical features, blood examination, electrophysiological examination, spinal magnetic resonance imaging and therapeutic efficacy profiles.

Results: The male-to-female ratio was 4:6 and it presented with an age-of-onset 17-26 years [the average age: (20. Read More

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[Mechanical thrombectomy treatment in patients with acute ischemic stroke: a single center study].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):256-259

Department of Interventional Radiologyand Vascular Surgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To evaluate the effectiveness and safety of mechanical thrombectomy treatment in patients with acute ischemic stroke (AIS),and to explore influential factors of the clinical prognosis preliminarily.

Methods: Clinical data of 26 patients with acute cerebral arterial occlusion treated with mechanical thrombectomy in Peking University Third Hospital from January 2014 to June 2017 were retrospectively collected. The immediate effects of the 26 patients in this group after mechanical thrombectomy treatment were analyzed,The national institutes of health stroke scale (NIHSS) scores between preoperative and at discharge of the 26 patients in this group were compared,and modified Rankin scale (mRS) scores of 90 days post operation were analyzed to assess the prognosis of the 26 patients in this group. Read More

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Restoration of brain circulation and cellular functions hours post-mortem.

Nature 2019 Apr 17;568(7752):336-343. Epub 2019 Apr 17.

Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.

The brains of humans and other mammals are highly vulnerable to interruptions in blood flow and decreases in oxygen levels. Here we describe the restoration and maintenance of microcirculation and molecular and cellular functions of the intact pig brain under ex vivo normothermic conditions up to four hours post-mortem. We have developed an extracorporeal pulsatile-perfusion system and a haemoglobin-based, acellular, non-coagulative, echogenic, and cytoprotective perfusate that promotes recovery from anoxia, reduces reperfusion injury, prevents oedema, and metabolically supports the energy requirements of the brain. Read More

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http://www.nature.com/articles/s41586-019-1099-1
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http://dx.doi.org/10.1038/s41586-019-1099-1DOI Listing
April 2019
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Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells.

Sci Rep 2019 Apr 17;9(1):6400. Epub 2019 Apr 17.

Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42588-xDOI Listing