391,792 results match your criteria Neurology Now [Journal]


[Study on the relationship between age-related hearing loss and cognitive impairment].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):110-115

Department of Otorhinolaryngology, Peking University People's Hospital, Beijing 100044, China.

To investigate the correlation between age-related hearing loss and cognitive impairment. 201 elderly patients, who were admitted to the Department of Otorhinolaryngology of Peking University People's Hospital from March 1, 2017 to March 31, 2017, were evaluated with hearing screening and the Montreal Cognitive Assessment Scale. Among them, 101 were female and 100 were male, aged 60-90 years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.003DOI Listing
February 2019

Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease.

Cortex 2019 Jan 29;115:99-111. Epub 2019 Jan 29.

Neurology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Parkinson's disease (PD) is characterized by dysfunction in frontal cortical and striatal networks that regulate action control. We investigated the pharmacological effect of dopamine agonist replacement therapy on frontal cortical activity and motor inhibition. Using Arterial Spin Labeling MRI, we examined 26 PD patients in the off- and on-dopamine agonist medication states to assess the effect of dopamine agonists on frontal cortical regional cerebral blood flow. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.01.016DOI Listing
January 2019

Spastic dystonia in stroke subjects: prevalence and features of the neglected phenomenon of the upper motor neuron syndrome.

Clin Neurophysiol 2019 Feb 6;130(4):521-527. Epub 2019 Feb 6.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Italy; Department of Neuroscience, IRCCS Ospedale Policlinico San Martino, Genova, Italy. Electronic address:

Objective: Spastic dystonia is one of the positive phenomena of the upper motor neuron syndrome (UMNS). It is characterised by the inability to relax a muscle leading to a spontaneous, although stretch-sensitive, tonic contraction. Although spastic dystonia is a recognized cause of muscle hypertonia, its prevalence among hypertonic muscles of stroke subjects has never been investigated. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.012DOI Listing
February 2019

The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 Feb 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
February 2019

CADASIL presenting with focal and generalised epilepsy due to a novel NOTCH3 mutation.

Seizure 2019 Jan 30;66:36-38. Epub 2019 Jan 30.

Department of Neurology, Auckland City Hospital, Private Bag 92024, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1016/j.seizure.2019.01.026DOI Listing
January 2019

Cerebrovascular disease burden in late-onset non-lesional focal epilepsy.

Seizure 2019 Feb 8;66:31-35. Epub 2019 Feb 8.

Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain. Electronic address:

Purpose: Late-onset non-lesional focal epilepsy, defined as new-onset seizures in patients older than 60 years, is diagnosed increasingly more often in relation to aging of the population. It has been attributed mainly to occult cerebral small vessel disease (SVD), although high levels of evidence to support this notion are lacking. This study aimed to evaluate the burden of leukoaraiosis, a marker of cerebral SVD, and hippocampal atrophy in patients with late-onset epilepsy (LOE). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.004DOI Listing
February 2019

Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome.

Seizure 2019 Jan 28;66:26-30. Epub 2019 Jan 28.

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Electronic address:

Purpose: This study aimed to investigate the genetic etiology of epilepsy in a cohort of Chinese children.

Methods: Targeted next-generation sequencing (NGS) was performed for 120 patients with unexplained epilepsy, including 71 patients with early-onset epileptic encephalopathies, and 16 patients with Dravet syndrome (including three patients with a Dravet-like phenotype) but without SCN1A pathogenic variants.

Results: Pathogenic variants of 14 genes were discovered in 22 patients (18%). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.025DOI Listing
January 2019

Generation of induced pluripotent stem cell line (ZZUi0012-A) from a patient with Fahr's disease caused by a novel mutation in SLC20A2 gene.

Stem Cell Res 2019 Jan 28;35:101395. Epub 2019 Jan 28.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:

Several SLC20A2 mutations have been implicated as potential causes of Fahr's disease, a subtype of primary familial brain calcification (PFBC), but very few patient-derived induced pluripotent stem cell (iPSC) models have been established. We have identified a novel SLC20A2 mutation in a family with Fahr's disease. We subsequently obtained dermal fibroblasts from a patient in this family. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101395DOI Listing
January 2019

The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals.

Neurobiol Aging 2019 Jan 21;77:26-36. Epub 2019 Jan 21.

Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Many individuals live to older ages without clinical impairment. It is unknown whether brain pathologies in these individuals are associated with subtle clinical deficits. We analyzed the brains of 161 clinically normal (Clinical Dementia Rating score = 0) older individuals enrolled in the Mayo Clinic Patient Registry or Study of Aging. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.008DOI Listing
January 2019

Reliability of supraspinal correlates to lower urinary tract stimulation in healthy participants - A fMRI study.

Neuroimage 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland. Electronic address:

Previous functional neuroimaging studies provided evidence for a specific supraspinal network involved in lower urinary tract (LUT) control. However, data on the reliability of blood oxygenation level-dependent (BOLD) signal changes during LUT task-related functional magnetic resonance imaging (fMRI) across separate measurements are lacking. Proof of the latter is crucial to evaluate whether fMRI can be used to assess supraspinal responses to LUT treatments. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.031DOI Listing
February 2019

Intra-arterial dantrolene for refractory cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.

World Neurosurg 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, University of Missouri Hospital and Clinics, Columbia, Missouri, USA.

Background: Dantrolene has a safe side-effect profile and a mechanism of action that makes it attractive as an option for treatment of cerebral vasospasm. The authors report two cases of refractory cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that were successfully treated with intra-arterial dantrolene.

Case Descriptions: Two patients, a 63-year-old woman and 36-year-old woman, developed severe vasospasm refractory to intra-arterial vasodilators after rupture of anterior communicating artery aneurysms. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.239DOI Listing
February 2019

Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women.

Brain Behav Immun 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan; Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan.

Background: Omega-3 polyunsaturated fatty acids (PUFAs) reduce depressive symptoms through an anti-inflammatory effect, and injection of both omega-3 PUFAs and estradiol (E2) induces antidepressant-like effects in rats by regulating the expression of inflammatory cytokines. The aims of this study were to examine the association of increased E2 during pregnancy with depressive symptoms and with inflammatory cytokines in women who were and were not supplemented with omega-3 PUFAs.

Methods: Pregnant women with Edinburgh Postnatal Depression Scale scores ≥ 9 were recruited at 12-24 weeks of gestation. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.014DOI Listing
February 2019

TELOMERE LENGTH AND HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSES OF OBSERVATIONAL STUDIES.

Ageing Res Rev 2019 Feb 15. Epub 2019 Feb 15.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy; Ambulatory of Nutrition, IRCCS "S. de Bellis" National Institute of Gastroenterology-Research Hospital Castellana Grotte Bari Italy, Italy. Electronic address:

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. Read More

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http://dx.doi.org/10.1016/j.arr.2019.02.003DOI Listing
February 2019
4.940 Impact Factor

A Palm-Worn Device to Quantify Rigidity in Parkinson's Disease.

J Neurosci Methods 2019 Feb 15. Epub 2019 Feb 15.

Bionics Institute, East Melbourne, Victoria, Australia; Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia.

Background: Parkinsonian rigidity is identified on clinical examination as resistance to passive movement. Measurement of rigidity commonly relies on ordinal rating scales (MDS-UPDRS), however instrumented objective measures may provide greater mechanistic insight.

New Method: We present a palm-worn instrument to objectively quantify rigidity on a continuous scale. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.02.006DOI Listing
February 2019
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Relative quantification of plasma N-glycans in type II congenital disorder of glycosylation patients by mass spectrometry.

Clin Chim Acta 2019 Feb 15. Epub 2019 Feb 15.

Laboratório de Síntese e Análise de Biomoléculas - LSAB, Instituto de Química - IQ, Universidade de Brasília - UnB, Brasília, DF, Brazil. Electronic address:

Background: Type II Congenital Disorders of Glycosylation (CDG-II) are a group of diseases with challenging diagnostics characterized by defects in the processing of glycans in the Golgi apparatus. Mass Spectrometry (MS) has been a valuable tool in the definition of CDG-II subtypes. While some CDG-II subtypes are associated with specific N-glycan structures, others only produce changes in relative levels, reinforcing the demand for quantification methods. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.013DOI Listing
February 2019

α-Synuclein induced mitochondrial dysfunction via cytochrome c oxidase subunit 2 in SH-SY5Y cells.

Exp Cell Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou 510080, China. Electronic address:

The transfer of misfolded α-Synuclein (α-Syn) from cell to cell as a prion protein is important in α-Synucleinopathies. Extraneous α-Syn induces apoptosis of dopaminergic neurons by causing mitochondrial dysfunction. However, the mechanism by which α-Syn disrupts the mitochondrial function is still unclear. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.02.006DOI Listing
February 2019

Endogenous multidien rhythm of epilepsy in rats.

Exp Neurol 2019 Feb 15. Epub 2019 Feb 15.

Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.

Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal. Here, we analyzed chronic EEG data (>30 days) in male epileptic rats and unraveled not only circadian but also, slower, multidien rhythms of interictal epileptiform activity with periodicity of about 2-3 and 5-7 days. Importantly, seizures were not uniformly distributed over time, but rather clustered at preferential phases of these underlying rhythms, delineating critical circadian times and multidien phase of heightened seizure risk. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.02.006DOI Listing
February 2019

[Editorial. Neurodevelopment and autism].

Authors:
Roberto Tuchman

Medicina (B Aires) 2019 ;79 Suppl 1:2-3

Department of Neurology. Nicklaus Children's Hospital. Miami Children's Health System. Florida. USA. E-mail:

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January 2019

Age-specific Associations between Estradiol, Cortico-Amygdalar Structural Covariance, Verbal and Spatial Skills.

J Neuroendocrinol 2019 Feb 18:e12698. Epub 2019 Feb 18.

Brain Development Cooperative Group.

Estradiol is known to play an important role in the developing human brain, but little is known on the entire network of potential regions which might be affected and on how these effects may vary from childhood to early adulthood, which in turn can explain sexually differentiated behaviors. Here we examined the relationship between estradiol, cortico-amygdalar structural covariance, and cognitive or behavioral measures typically showing sex differences (verbal/spatial skills, anxious-depressed symptomatology) in 152 children and adolescents (6-22 years old). Cortico-amygdalar structural covariance shifted from positive to negative across the age range. Read More

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http://dx.doi.org/10.1111/jne.12698DOI Listing
February 2019

Comparative sensitivity of the MoCA and Mattis Dementia Rating Scale-2 in Parkinson's disease.

Mov Disord 2019 Feb 10;34(2):285-291. Epub 2018 Dec 10.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.

Background: Clinicians and researchers commonly use global cognitive assessments to screen for impairment. Currently there are no published studies directly comparing the sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 in PD. The objective of this study was to identify the relative sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 in PD. Read More

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http://dx.doi.org/10.1002/mds.27575DOI Listing
February 2019

Investigative practice into sudden death in epilepsy: A global survey.

Acta Neurol Scand 2019 Feb 18. Epub 2019 Feb 18.

Department of Intellectual Disability Neuropsychiatry, Cornwall Partnership NHS Foundation Trust, Truro, TR1 3QB, UK.

Objectives: Sudden death is a recognised consequence of epilepsy. Little is known about the practice of confirming the cause of sudden death from most nations. We sought to determine how often autopsy is undertaken, clinician confidence in cause of death, and identify the factors which may influence autopsy utilization. Read More

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http://dx.doi.org/10.1111/ane.13080DOI Listing
February 2019

Clinical Outcomes of Escalation vs Early Intensive Disease-Modifying Therapy in Patients With Multiple Sclerosis.

JAMA Neurol 2019 Feb 18. Epub 2019 Feb 18.

Institute of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom.

Importance: Uncertainty remains about how aggressively to treat early multiple sclerosis. High-efficacy disease-modifying therapies (DMTs) are often reserved for individuals expressing poor prognostic features at baseline.

Objective: To analyze long-term outcomes in a population-based cohort according to initial treatment strategy. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.4905DOI Listing
February 2019

Effect of vestibular rehabilitation on recovery rate and functioning improvement in patients with chronic unilateral vestibular hypofunction and bilateral vestibular hypofunction.

NeuroRehabilitation 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology, County General and Veterans Hospital Vukovar, Vukovar, Croatia.

Background: The minimal number of studies have documented the impact of Vestibular rehabilitation (VR) on the recovery rate of patients with Chronic Unilateral Vestibular Hypofunction (CUVH) and Bilateral Vestibular Hypofunction (BVH).

Objectives: The goal of the study was to show and compare the impact of vestibular rehabilitation (VR) in patients with CUVH and BVH.

Methods: We analysed the data of 30 patients with CUVH and 20 with BVH treated with VR. Read More

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http://dx.doi.org/10.3233/NRE-182524DOI Listing
February 2019

Huntington's Disease Clinical Trials Corner: January 2019.

J Huntingtons Dis 2019 ;8(1):115-125

UCL Huntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, UK.

In this edition of the Huntington's Disease Clinical Trials Corner we expand on the GENERATION-HD1 and PACE-HD trials, and we list all currently registered and ongoing clinical trials in Huntington's disease. Read More

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http://dx.doi.org/10.3233/JHD-190001DOI Listing
January 2019

Is Alzheimer's Disease Risk Modifiable?

J Alzheimers Dis 2019 ;67(3):795-819

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Population-based clinic-pathological studies have established that the most common pathological substrate of dementia in community-dwelling elderly people is mixed, especially Alzheimer's disease (AD) and cerebrovascular ischemic disease (CVID), rather than pure AD. While these could be just two frequent unrelated comorbidities in the elderly, epidemiological research has reinforced the idea that mid-life (age <65 years) vascular risk factors increase the risk of late-onset (age ≥ 65 years) dementia, and specifically AD. By contrast, healthy lifestyle choices such as leisure activities, physical exercise, and Mediterranean diet are considered protective against AD. Read More

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http://dx.doi.org/10.3233/JAD181028DOI Listing
January 2019

Connectivity Between Brain Networks Dynamically Reflects Cognitive Status of Parkinson's Disease: A Longitudinal Study.

J Alzheimers Dis 2019 ;67(3):971-984

Applied Neuroscience Research Group, Central European Institute of Technology, Masaryk University (CEITEC MU), Brno, Czech Republic.

Background: Cognitive impairment in Parkinson's disease (PD) is associated with altered connectivity of the resting state networks (RSNs). Longitudinal studies in well cognitively characterized PD subgroups are missing.

Objectives: To assess changes of the whole-brain connectivity and between-network connectivity (BNC) of large-scale functional networks related to cognition in well characterized PD patients using a longitudinal study design and various analytical methods. Read More

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http://dx.doi.org/10.3233/JAD-180834DOI Listing
January 2019

Cognitive Improvement with Glutathione Supplement in Alzheimer's Disease: A Way Forward.

J Alzheimers Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting millions of people worldwide. The actual cause of AD is still unknown. Oxidative stress is believed to be important player in AD. Read More

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http://dx.doi.org/10.3233/JAD-181054DOI Listing
February 2019

Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease.

J Alzheimers Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health (DINOGMI), University of Genoa, Italy.

Background: Several automatic tools have been implemented for semi-quantitative assessment of brain [18]F-FDG-PET.

Objective: We aimed to head-to-head compare the diagnostic performance among three statistical parametric mapping (SPM)-based approaches, another voxel-based tool (i.e. Read More

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http://dx.doi.org/10.3233/JAD-181022DOI Listing
February 2019

FTIR Spectroscopy of Cerebrospinal Fluid Reveals Variations in the Lipid: Protein Ratio at Different Stages of Alzheimer's Disease.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Faculty of Mathematics and Natural Sciences, Centre for Innovation and Transfer of Natural Sciences and Engineering Knowledge, University of Rzeszow, Poland.

Alzheimer's disease (AD) is a disease of advanced civilization and a common form of dementia in people over 65 years of age. We used Fourier transform infrared (FTIR) spectroscopy combined with principal component analysis (PCA) to determine changes in the quantity and quality of the cerebrospinal fluid from AD patients at three different stages of the disease (ADI, ADII, and ADIII), as well as from patients with mild cognitive impairment (MCI). Moreover, based on the FTIR spectra, we calculated the ratio of α-helix and β-sheet secondary protein structures as well as the lipid-protein balance as potential AD markers. Read More

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http://dx.doi.org/10.3233/JAD-181008DOI Listing
February 2019

Neuropathological Diagnoses of Demented Hispanic, Black, and Non-Hispanic White Decedents Seen at an Alzheimer's Disease Center.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, University of California, Davis, Sacramento, CA, USA.

Our nation is becoming increasingly diverse; however, few autopsy studies examine multiple ethnoracial groups, especially Hispanics. We examined differences in neuropathological diagnoses of 435 deceased participants with dementia from three ethnoracial groups (35 Black, 28 Hispanic, and 360 non-Hispanic White) evaluated at the University of California Davis Alzheimer's Disease Center. We used novel applications of bootstrap resampling and logistic regression standardization to project neuropathological diagnostic rates for non-Hispanic Whites to minority sample characteristics to improve inference of findings. Read More

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http://dx.doi.org/10.3233/JAD-180992DOI Listing
February 2019

White Matter Hyperintensities in Alzheimer's Disease: A Lesion Probability Mapping Study.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Medical University of Graz, Graz, Austria.

Background/objective: Higher white matter hyperintensity (WMH) load has been reported in Alzheimer's disease (AD) patients in different brain regions when compared to controls. We aimed to assess possible differences of WMH spatial distribution between AD patients and age-matched controls by means of lesion probability maps.

Methods: The present study included MRI scans of 130 probable AD patients with a mean age of 73. Read More

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http://dx.doi.org/10.3233/JAD-180982DOI Listing
February 2019

Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

Hyperhomocysteinemia is an independent risk factor of Alzheimer's disease (AD), which is not diagnosed for many years before onset due to lack of peripherally detectable early biomarkers. Visual dysfunction is prevalent in AD patients and correlates with the severity of cognitive defects. Importantly, alterations in eyes can be non-invasively detected. Read More

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http://dx.doi.org/10.3233/JAD-180978DOI Listing
February 2019

Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.

Genome-wide association studies identified a single nucleotide polymorphism (SNP) in the MSRB3 gene encoding Methionine Sulfoxide Reductase-B3 (MsrB3) to be associated with the risk for low hippocampal volume and late onset Alzheimer's disease (AD). Subsequently, we identified AD-associated abnormal patterns of neuronal and vascular MsrB3 expression in postmortem hippocampi. The present study investigated the relationship between the MSRB3 SNP rs61921502, G (minor/risk allele) and MRI measures of brain injury including total brain volume, hippocampal volume, and white matter hyperintensities using linear regression models; the presence of brain infarcts using logistic regression models; and the incidence of stroke, dementia, and AD using Cox proportional hazards models in 2,038 Framingham Heart Study Offspring participants with MRI administered close to examination cycle 7 (1998-2001). Read More

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http://dx.doi.org/10.3233/JAD-180977DOI Listing
February 2019

The Influence of BDNF Val66Met Polymorphism on Cognition, Cerebrospinal Fluid, and Neuroimaging Markers in Non-Demented Elderly.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Background: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism emerged as a risk factor for Alzheimer's disease (AD). However, little was known about its effects on the process of potential AD.

Objective: To explore the effects of the Val66Met polymorphism on cognition, cerebrospinal fluid (CSF), and neuroimaging markers in non-demented elderly individuals. Read More

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http://dx.doi.org/10.3233/JAD-180971DOI Listing
February 2019

Vascular Burden Score Impacts Cognition Independent of Amyloid PET and MRI Measures of Alzheimer's Disease and Vascular Brain Injury.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

UC Davis Department of Neurology and Center for Neuroscience, Davis, CA, USA.

Background/objective: To determine the impact of vascular burden on rates of decline in episodic memory and executive function. We hypothesize that greater vascular burden will have an additive negative impact on cognition after accounting for baseline cognitive impairment, positron emission tomography (PET) amyloid burden, and magnetic resonance imaging (MRI) measures.

Methods: Individuals were followed an average of 5 years with serial cognitive assessments. Read More

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http://dx.doi.org/10.3233/JAD-180965DOI Listing
February 2019

Deep White Matter Lesions Are Associated with Early Recognition of Dementia in Alzheimer's Disease.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Neuroimages of cerebral amyloid-β (Aβ) accumulation and small vessel disease (SVD) were examined in patients with various types of cognitive disorders using 11C-labeled Pittsburgh Compound B-positron emission tomography (PiB-PET) and magnetic resonance imaging (MRI). The mean cortical standardized uptake value ratio (mcSUVR) was applied for a quantitative analysis of PiB-PET data. The severity of white matter lesions (WML) and enlarged perivascular spaces (EPVS) on MRI were assessed to evaluate complicating cerebral SVD using semiquantitative scales. Read More

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http://dx.doi.org/10.3233/JAD-180939DOI Listing
February 2019

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.

J Alzheimers Dis 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurology, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Type 2 diabetes mellitus (T2DM) increases the risk of vascular cognitive impairment (VCI). It is unknown which type of vascular lesions and co-morbid etiologies, in particular Alzheimer's disease pathology, are associated with T2DM in patients with VCI, and how this relates to cognition and prognosis.

Objective: To compare brain MRI and cerebrospinal fluid (CSF) markers, cognition, and prognosis in patients with possible VCI with and without T2DM. Read More

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http://dx.doi.org/10.3233/JAD-180914DOI Listing
February 2019

Early-Stage Alzheimer's Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA.

Background: Brain insulin resistance is a well-recognized abnormality in Alzheimer's disease (AD) and the likely mediator of impaired glucose utilization that emerges early and progresses with disease severity. Moreover, the rates of mild cognitive impairment (MCI) or AD are significantly greater in people with diabetes mellitus or obesity.

Objective: This study was designed to determine whether systemic and central nervous system (CNS) insulin resistant disease states emerge together and thus may be integrally related. Read More

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http://dx.doi.org/10.3233/JAD-180906DOI Listing
February 2019

CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.

J Alzheimers Dis 2019 Feb 9. Epub 2019 Feb 9.

Department of Neurology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

We previously demonstrated that microglia play an essential role in clearance of amyloid-β (Aβ) in Alzheimer's disease (AD)-like pathology. Our prior work also showed that several receptors expressed on microglia participated in Aβ phagocytosis. However, clathrin-mediated endocytosis (CME), which is associated with production and release of Aβ in neurons, has received much less attention in the context of microglial Aβ uptake. Read More

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http://dx.doi.org/10.3233/JAD-180904DOI Listing
February 2019

Distinctive Neurochemistry in Alzheimer's Disease via 7 T In Vivo Magnetic Resonance Spectroscopy.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

This study's objective was to increase understanding of biological mechanisms underlying clinical Alzheimer's disease (AD) by noninvasively measuring an expanded neurochemical profile and exploring how well this advanced technology distinguishes AD from cognitively normal controls. We measured concentrations of 14 neurochemicals using ultra-high field (7 T) ultra-short echo time (8 ms) magnetic resonance spectroscopy (MRS) in 16 participants with mild to moderate clinical AD and 33 age- and gender-matched control participants. MRS was localized to the posterior cingulate cortex (PCC), a region known to be impacted by AD, and the occipital cortex (OCC), a control region. Read More

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http://dx.doi.org/10.3233/JAD-180861DOI Listing
February 2019

Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Read More

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http://dx.doi.org/10.3233/JAD-180785DOI Listing
February 2019

The Alz-tau Biomarker for Alzheimer's Disease: Study in a Caucasian Population.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Laboratory of Neuroscience, International Center for Biomedicine (ICC) and Faculty of Sciences, University of Chile, Santiago, Chile.

The establishment of a molecular biomarker for early detection of Alzheimer's disease (AD) is critical for diagnosis and follow up of patients, and as a quantitative parameter in the evaluation of potential new drugs to control AD. A list of blood biomarkers has been reported but none has been validated for the Alzheimer's clinic. The changes in hyperphosphorylated tau and amyloid peptide in the cerebrospinal fluid is currently used as a tool in the clinics and for research purposes, but this method is highly invasive. Read More

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http://dx.doi.org/10.3233/JAD-180637DOI Listing
February 2019

Early Identification of Central Retinal Artery Occlusion Using Point-of-care Ultrasound.

Clin Pract Cases Emerg Med 2019 Feb 4;3(1):13-15. Epub 2019 Jan 4.

University of Washington School of Medicine, Department of Emergency Medicine, Seattle, Washington.

A 69-year-old woman with a history of untreated hypertension presented with acute-onset monocular vision loss. Initial workup was delayed due to lack of immediate specialty consultation and dilated funduscopic exam. Point-of-care ultrasound in the emergency department identified a small hyperechoic structure within the distal area of the central retinal artery; in conjunction with specialty ophthalmologic evaluation in a tertiary care center, the diagnosis of central retinal artery occlusion was made. Read More

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http://dx.doi.org/10.5811/cpcem.2018.11.39406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366367PMC
February 2019

Floppy eyelid syndrome in stickler syndrome.

Am J Ophthalmol Case Rep 2019 Jun 31;14:14-15. Epub 2019 Jan 31.

Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.

Purpose: To report the possible connection between Stickler syndrome and floppy eyelid syndrome.

Observations: A 36-year-old man with genetically confirmed Stickler syndrome presented with prominent bilateral eyelid laxity consistent with floppy eyelid syndrome. He had a high-arched palate and reported years of apneic episodes during sleep consistent with obstructive sleep apnea (OSA). Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365810PMC

Chemotherapy-related cognitive dysfunction and effects on quality of life in gynecologic cancer patients.

Expert Rev Qual Life Cancer Care 2018 26;3(1):19-26. Epub 2018 Feb 26.

Department of Neurology, Department of Neurological Surgery, and Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.

Introduction: chemotherapy-related cognitive dysfunction (CRCD) is a growing problem due to rising cancer rates and increasing numbers of cancer survivors. upwards of 70% of ovarian cancer patients report cognitive-changes following treatment for their cancer.

Areas Covered: the underlying mechanisms of CRCD are a subject of active research and debate. Read More

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http://dx.doi.org/10.1080/23809000.2018.1443811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377208PMC
February 2018

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice.

Sci Adv 2019 Feb 6;5(2):eaau8317. Epub 2019 Feb 6.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Read More

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http://dx.doi.org/10.1126/sciadv.aau8317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365110PMC
February 2019

A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease.

Sci Adv 2019 Feb 6;5(2):eaau7220. Epub 2019 Feb 6.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London, UK.

A blood-based assessment of preclinical disease would have huge potential in the enrichment of participants for Alzheimer's disease (AD) therapeutic trials. In this study, cognitively unimpaired individuals from the AIBL and KARVIAH cohorts were defined as Aβ negative or Aβ positive by positron emission tomography. Nontargeted proteomic analysis that incorporated peptide fractionation and high-resolution mass spectrometry quantified relative protein abundances in plasma samples from all participants. Read More

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http://dx.doi.org/10.1126/sciadv.aau7220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365111PMC
February 2019

Human consciousness is supported by dynamic complex patterns of brain signal coordination.

Sci Adv 2019 Feb 6;5(2):eaat7603. Epub 2019 Feb 6.

INSERM, U 1127, F-75013 Paris, France.

Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns. Read More

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http://dx.doi.org/10.1126/sciadv.aat7603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365115PMC
February 2019

Measles Virus-Based Treatments Trigger a Pro-inflammatory Cascade and a Distinctive Immunopeptidome in Glioblastoma.

Mol Ther Oncolytics 2019 Mar 31;12:147-161. Epub 2018 Dec 31.

Interdisciplinary Division of Neuro-Oncology, Hertie Institute for Clinical Brain Research, Departments of Neurology and Neurosurgery, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen 72076, Germany.

Glioblastoma is an aggressive primary brain tumor with bad prognosis. On the other hand, oncolytic measles virus (MeV) therapy is an experimental glioma treatment strategy with clinical safety and first evidence of anti-tumoral efficacy. Therefore, we investigated the combination of MeV with conventional therapies by cytotoxic survival assays in long-term glioma cell lines LN229, LNZ308, and glioma stem-like GS8 cells, as well as the basal viral infectivity in primary glioblastoma cultures T81/16, T1094/17, and T708/16. Read More

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http://dx.doi.org/10.1016/j.omto.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365369PMC

From brain collections to modern brain banks: A historical perspective.

Alzheimers Dement (N Y) 2019 5;5:52-60. Epub 2019 Feb 5.

University of Pavia, Pavia, Italy.

Our current knowledge of the structure, function, and diseases of the brain comes from direct examination of its substance. In the last centuries, only a few elite had managed to retrieve, gather, and preserve the elusive brain for their own research. The resulting brain collections, stored in formalin-filled jars or dried up in cabinets, served anatomical, neuropathological, anthropometric, ideological, and diagnostic purposes. Read More

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http://dx.doi.org/10.1016/j.trci.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365388PMC
February 2019