49,551 results match your criteria Neurology[Journal]


Correction to Lancet Neurol 2019; 18: 177-84.

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Lancet Neurol 2019 Mar 12;18(3):e2. Epub 2019 Feb 12.

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http://dx.doi.org/10.1016/S1474-4422(19)30036-5DOI Listing

Correction to Lancet Neurol 2019; 18: 46-55.

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Lancet Neurol 2019 Mar 12;18(3):e2. Epub 2019 Feb 12.

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http://dx.doi.org/10.1016/S1474-4422(19)30037-7DOI Listing

Correction to Lancet Neurol 2018; 17: 47-53.

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Lancet Neurol 2019 Mar 12;18(3):e2. Epub 2019 Feb 12.

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http://dx.doi.org/10.1016/S1474-4422(19)30038-9DOI Listing

Association between circadian rhythms and neurodegenerative diseases.

Lancet Neurol 2019 Mar 12;18(3):307-318. Epub 2019 Feb 12.

Department of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA; San Francisco VA Medical Center, San Francisco, CA, USA.

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease. Manifestations of circadian rhythm disruptions differ according to the type and severity of neurodegenerative disease and, for some patients, occur before the onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30461-7DOI Listing

Traumatic brain injury in China.

Lancet Neurol 2019 Mar 12;18(3):286-295. Epub 2019 Feb 12.

Department of Neurosurgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

China has more patients with traumatic brain injury (TBI) than most other countries in the world, making this condition a major public health concern. Population-based mortality of TBI in China is estimated to be approximately 13 cases per 100 000 people, which is similar to the rates reported in other countries. The implementation of various measures, such as safety legislation for road traffic, establishment of specialised neurosurgical intensive care units, and the development of evidence-based guidelines, have contributed to advancing prevention and care of patients with TBI in China. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30469-1DOI Listing

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study.

Lancet Neurol 2019 Mar 12;18(3):248-258. Epub 2019 Feb 12.

Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and University of Oxford, Oxford, UK.

Background: Risk of dementia after stroke is a major concern for patients and carers. Reliable data for risk of dementia, particularly after transient ischaemic attack or minor stroke, are scarce. We studied the risks of, and risk factors for, dementia before and after transient ischaemic attack and stroke. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30442-3DOI Listing

Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I).

Lancet Neurol 2019 Mar 12;18(3):238-247. Epub 2019 Feb 12.

Waseda University Faculty of Science and Engineering, Tokyo, Japan.

Background: The effect of prasugrel in terms of the prevention of recurrence of ischaemic stroke is unknown. We investigated the non-inferiority of prasugrel to clopidogrel for prevention of ischaemic stroke, myocardial infarction, and death from other vascular causes in Japanese patients with non-cardioembolic stroke.

Methods: In this phase 3 randomised, double-blind, non-inferiority trial, patients aged 20-74 years who had had a non-cardioembolic stroke in the previous 1-26 weeks were recruited from 224 hospitals in Japan. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30449-6DOI Listing

Felix Mendelssohn's family's brain condition.

Lancet Neurol 2019 Mar 12;18(3):237. Epub 2019 Feb 12.

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http://dx.doi.org/10.1016/S1474-4422(19)30016-XDOI Listing

Outbreaks of acute flaccid myelitis? What neurologists need to know.

Authors:
Adrian Burton

Lancet Neurol 2019 Mar 12;18(3):234-235. Epub 2019 Feb 12.

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http://dx.doi.org/10.1016/S1474-4422(19)30015-8DOI Listing

The Madwoman: a portrait of a choreic woman?

Lancet Neurol 2019 Mar 12;18(3):233. Epub 2019 Feb 12.

Clinica Neurologica, Dipartimento di Medicina, Azienda Ospedaliero, Universitaria di Perugia, Italy.

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http://dx.doi.org/10.1016/S1474-4422(18)30502-7DOI Listing

Optimal stroke prevention in patients with PFO.

Lancet Neurol 2019 Mar 12;18(3):231. Epub 2019 Feb 12.

Neurovascular Treatment Unit, Department of Human Neurosciences, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1016/S1474-4422(19)30017-1DOI Listing

The risk of PML from natalizumab - Authors' reply.

Lancet Neurol 2019 Mar 12;18(3):230-231. Epub 2019 Feb 12.

Biogen, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/S1474-4422(19)30022-5DOI Listing

The risk of PML from natalizumab.

Authors:
Bastian Tugemann

Lancet Neurol 2019 Mar 12;18(3):230. Epub 2019 Feb 12.

Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30021-3DOI Listing

The long journey towards uniform epidemiological monitoring of TBI around the globe.

Authors:
Marc Maegele

Lancet Neurol 2019 Mar 12;18(3):228-229. Epub 2019 Feb 12.

Department of Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Center, University of Witten/Herdecke, 200, Cologne, 51109, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30019-5DOI Listing

Dementia risk after transient ischaemic attack and stroke.

Authors:
Martin Dichgans

Lancet Neurol 2019 Mar 12;18(3):223-225. Epub 2019 Feb 12.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Feodor-Lynen-Straße 17, D-81377, Munich, Germany; German Center for Neurodegenerative Diseases, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30497-6DOI Listing

Prasugrel or clopidogrel for long-term secondary stroke prevention?

Authors:
Graeme J Hankey

Lancet Neurol 2019 Mar 12;18(3):222-223. Epub 2019 Feb 12.

Medical School, Faculty of Health and Medical Sciences, The University of Western Australia, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, Perth 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30018-3DOI Listing

Complicated decisions on new migraine-prevention therapies.

Lancet Neurol 2019 Mar 12;18(3):221. Epub 2019 Feb 12.

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http://dx.doi.org/10.1016/S1474-4422(19)30041-9DOI Listing

Fibrinogen links vascular pathology to cognitive decline.

Authors:
Heather Wood

Nat Rev Neurol 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Neurology, .

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http://dx.doi.org/10.1038/s41582-019-0154-8DOI Listing
February 2019

Therapeutic landscape for Batten disease: current treatments and future prospects.

Nat Rev Neurol 2019 Feb 19. Epub 2019 Feb 19.

Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA.

Batten disease (also known as neuronal ceroid lipofuscinoses) constitutes a family of devastating lysosomal storage disorders that collectively represent the most common inherited paediatric neurodegenerative disorders worldwide. Batten disease can result from mutations in 1 of 13 genes. These mutations lead to a group of diseases with loosely overlapping symptoms and pathology. Read More

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http://dx.doi.org/10.1038/s41582-019-0138-8DOI Listing
February 2019

A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze.

BMC Neurol 2019 Feb 19;19(1):28. Epub 2019 Feb 19.

Department of Neurology, Harrison International Peace Hospital, 2 Renmin Zhong Road, Taocheng District, Hengshui, 050000, Hebei, China.

Background: Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports. To our knowledge, there was no report on anti GQ1b antibody syndrome accompanied by PPG. This paper reported a case of anti GQ1b antibody syndrome with Bickerstaff's Encephalitis (BBE) overlapping classic Guillain-Barre Syndrome (GBS) after aortic valve replacement, accompanied by an excessive PPG in the course of diagnosis and treatment, this was indeed rarely. Read More

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http://dx.doi.org/10.1186/s12883-019-1258-xDOI Listing
February 2019

Promoting faster pathways to surgery: a clinical audit of patients with refractory epilepsy.

BMC Neurol 2019 Feb 19;19(1):29. Epub 2019 Feb 19.

Australian Institute of Health Innovation, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Background: Individuals with epilepsy who cannot be adequately controlled with anti-epileptic drugs, refractory epilepsy, may be suitable for surgical treatment following detailed assessment. This is a complex process and there are concerns over delays in referring refractory epilepsy patients for surgery and subsequent treatment. The aim of this study was to explore the different patient pathways, referral and surgical timeframes, and surgical and medical treatment options for refractory epilepsy patients referred to two Tertiary Epilepsy Clinics in New South Wales, Australia. Read More

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http://dx.doi.org/10.1186/s12883-019-1255-0DOI Listing
February 2019

Long-term outcomes of deep brain stimulation in Parkinson disease.

Nat Rev Neurol 2019 Feb 18. Epub 2019 Feb 18.

Department of Clinical and Movement Neurosciences, University College London, Queen Square Institute of Neurology, London, UK.

The efficacy of deep brain stimulation (DBS) for Parkinson disease (PD) is well established for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically discuss the evidence on the long-term outcomes of DBS and consider the clinical implications. Although many patients are lost to follow-up, the evidence indicates that subthalamic nucleus DBS improves motor function for up to 10 years, although the magnitude of improvement tends to decline over time. Read More

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http://dx.doi.org/10.1038/s41582-019-0145-9DOI Listing
February 2019

Exploring vascular Aβ pathology using microvessel extracts from frozen human brain samples.

Authors:
Rebecca Kelsey

Nat Rev Neurol 2019 Feb 18. Epub 2019 Feb 18.

Nature Reviews Neurology, .

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http://dx.doi.org/10.1038/s41582-019-0152-xDOI Listing
February 2019

Iron deposition in periaqueductal grey matter as a biomarker of chronic migraine.

Authors:
Rebecca Kelsey

Nat Rev Neurol 2019 Feb 18. Epub 2019 Feb 18.

Nature Reviews Neurology, .

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http://dx.doi.org/10.1038/s41582-019-0151-yDOI Listing
February 2019

Prodromal symptoms might vary between multiple sclerosis subtypes.

Authors:
Rebecca Kelsey

Nat Rev Neurol 2019 Feb 18. Epub 2019 Feb 18.

Nature Reviews Neurology, .

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http://dx.doi.org/10.1038/s41582-019-0150-zDOI Listing
February 2019

Teaching Video NeuroImages: Horizontal gaze palsy with progressive scoliosis.

Neurology 2019 Feb;92(8):e886-e887

From the Departments of Ophthalmology (H.K.Y., J.-M.H.), Neurology (J.-Y.C., K.S.P.), and Radiology (J.H.K.), Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

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http://dx.doi.org/10.1212/WNL.0000000000006962DOI Listing
February 2019

Teaching NeuroImages: MRI findings in an infant with cavitating leukoencephalopathy.

Neurology 2019 Feb;92(8):e884-e885

From the Division of Child Neurology, Department of Pediatrics (A.H., S.K.), and Department of Radiology (P.A.), Cohen Children's Medical Center, New Hyde Park, NY.

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http://dx.doi.org/10.1212/WNL.0000000000006965DOI Listing
February 2019

Education Research: An arts-based curriculum for neurology residents.

Neurology 2019 Feb;92(8):e879-e883

From the Department of Neurology, University of Virginia School of Medicine, Charlottesville.

Objective: To determine the feasibility and educational value of an arts-based curriculum for neurology residents, with the following specific learning objectives: to enhance communication and observational skills, increase awareness of point of view, and deepen appreciation of the narrative content of illness.

Methods: Narrative medicine and visual thinking exercises, adopted from the study of literature and art history, were offered as monthly sessions in the neurology residents' conference schedule. Participants completed an institutional review board-approved anonymous evaluation using a 5-point Likert scale to rate course effectiveness and perform a retrospective pre- and post-self-assessment of communication and visual observation skills. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006961DOI Listing
February 2019

Development of a neurology training program in Haiti.

Neurology 2019 Feb;92(8):391-394

From Partners in Health/Zanmi Lasante (K.I., L.M., M.E.M., A.L.B.), Hôpital Universitaire de Mirebalais, Haiti; Dartmouth College (S.M.S.), Hanover, NH; Faculté de Médecine et de Pharmacie de l'Universite d'Etat d'Haiti (S.P.), Port-au-Prince, Haiti; and Division of Global Health Equity, Department of Medicine (M.E.M.), and Department of Neurology (A.L.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000006960DOI Listing
February 2019

Right Brain: Flip to the other side.

Neurology 2019 Feb;92(8):390

From the Departments of Neuroanesthesia (D.G.) and Neurosurgery (K.C.J.), Cleveland Clinic, OH.

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http://dx.doi.org/10.1212/WNL.0000000000006951DOI Listing
February 2019

Shape-similar errors in Chinese pure alexia.

Neurology 2019 Feb;92(8):388-389

From the Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1212/WNL.0000000000006964DOI Listing
February 2019

What's happening in .

Authors:

Neurology 2019 Feb;92(8):376

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http://dx.doi.org/10.1212/WNL.0000000000006939DOI Listing
February 2019

Intracerebral haemorrhage during alemtuzumab administration.

Lancet Neurol 2019 Feb 15. Epub 2019 Feb 15.

College Park Family Care Center, Overland Park, KS, USA.

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http://dx.doi.org/10.1016/S1474-4422(19)30076-6DOI Listing
February 2019

Status Epilepticus in the Neonate: Updates in Treatment Strategies.

Curr Treat Options Neurol 2019 Feb 18;21(2). Epub 2019 Feb 18.

Division of Neurology, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University, 611 E Livingston Avenue FB4, Columbus, OH, 43205, USA.

Purpose Of Review: The purpose of this review is to report recent advances in treatment of neonatal seizures, with a specific focus on new literature since a 2013 systematic review performed by this author (Slaughter) and others. There is a paucity of data with regard to well-defined status epilepticus (SE) in neonates, so treatment of recurrent seizures was also included in this inquiry. We aimed to summarize the efficacy and safety profiles of current therapeutic options as well as describe trends in medication selection in the neonatal intensive care unit (NICU) setting. Read More

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http://dx.doi.org/10.1007/s11940-019-0546-5DOI Listing
February 2019

An unparalleled assessment of the global burden of epilepsy.

Authors:
W Allen Hauser

Lancet Neurol 2019 Feb 14. Epub 2019 Feb 14.

Sergievsky Center, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30042-0DOI Listing
February 2019

Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Authors:

Lancet Neurol 2019 Feb 14. Epub 2019 Feb 14.

Background: Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and location using data from the Global Burden of Diseases, Injuries, and Risk Factors Study. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30454-XDOI Listing
February 2019
21.896 Impact Factor

Validation of an algorithm for identifying MS cases in administrative health claims datasets.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Veterans Affairs Post Deployment Health Services (W.J.C., M.T.W.), Multiple Sclerosis Center of Excellence; University of Maryland (W.J.C.), Baltimore; Departments of Internal Medicine and Community Health Sciences (R.A.M., S.L.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Neurology Department (A.L.-G., L.H.C.), Kaiser Permanente Southern California, Los Angeles; Georgetown University School of Medicine (M.T.W.), Washington, DC; University of Colorado (J.C.), Denver; Stanford University School of Medicine (L.M.N.), CA; McKing Consulting Corp (W.E.K., L.W.), Atlanta, GA; Faculty of Medicine (Neurology) and Centre for Brain Health (H.T.), University of British Columbia, Vancouver; College of Pharmacy and Nutrition (C.E.), University of Saskatchewan; Health Quality Council (Saskatchewan) (S.Y.), Saskatoon, Canada; and National Multiple Sclerosis Society (N.G.L.), New York, NY.

Objective: To develop a valid algorithm for identifying multiple sclerosis (MS) cases in administrative health claims (AHC) datasets.

Methods: We used 4 AHC datasets from the Veterans Administration (VA), Kaiser Permanente Southern California (KPSC), Manitoba (Canada), and Saskatchewan (Canada). In the VA, KPSC, and Manitoba, we tested the performance of candidate algorithms based on inpatient, outpatient, and disease-modifying therapy (DMT) claims compared to medical records review using sensitivity, specificity, positive and negative predictive values, and interrater reliability (Youden J statistic) both overall and stratified by sex and age. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007043DOI Listing
February 2019

WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Institute for Stroke and Dementia Research, University Hospital (M.K.G., M. Duering, M. Dichgans), and Graduate School for Systemic Neurosciences (M.K.G.), Ludwig-Maximilians-Universität LMU, Munich, Germany; Division of Neuroimaging Science (J.M.W.), Centre for Clinical Brain Science, Edinburgh Imaging and UK Dementia Research Institute, University of Edinburgh, UK; Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans); and German Centre for Neurodegenerative Diseases (M. Dichgans), Munich, Germany.

Objective: To investigate the relationship between baseline white matter hyperintensities (WMH) in patients with ischemic stroke and long-term risk of dementia, functional impairment, recurrent stroke, and mortality.

Methods: Following the Meta-analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO protocol: CRD42018092857), we systematically searched Medline and Scopus for cohort studies of ischemic stroke patients examining whether MRI- or CT-assessed WMH at baseline are associated with dementia, functional impairment, recurrent stroke, and mortality at 3 months or later poststroke. We extracted data and evaluated study quality with the Newcastle-Ottawa scale. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007142DOI Listing
February 2019

The prevalence of MS in the United States: A population-based estimate using health claims data.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Veterans Affairs Multiple Sclerosis Center of Excellence (M.T.W., W.J.C.); Georgetown University School of Medicine (M.T.W.), Washington, DC; University of Maryland (W.J.C.), Baltimore; University of Colorado (J.D.C., P.D.), Aurora; Stanford University School of Medicine (L.M.N., B.T.), CA; Southern California Permanente Medical Group (A.L.-G., L.H.C.), Pasadena; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; University of Alabama at Birmingham (G.R.C.); McKing Consulting Corp (W.E.K., L.W.), Atlanta, GA; Faculty of Medicine (Neurology) and Centre for Brain Health (H.T.), University of British Columbia, Vancouver, Canada; Brown University (S.L.B.), Providence, RI; and National Multiple Sclerosis Society (N.G.L.), New York, NY.

Objective: To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets.

Methods: A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 2008 and 2010. In each dataset, we determined the 3-year cumulative prevalence overall and stratified by age, sex, and census region. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007035DOI Listing
February 2019

The underacknowledged PPA-ALS: A unique clinicopathologic subtype with strong heritability.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Brain and Mind Centre and Central Clinical School (R.H.T., B.G., C.D.-S., J.B.J.K., M.C.K., J.R.H., G.M.H.) and School of Medical Sciences (J.J.K.), Faculty of Medicine and Health, and Brain and Mind Centre and School of Psychology (O.P.), The University of Sydney; School of Medical Sciences (R.H.T., C.D.-S., G.M.H.), University of New South Wales & Neuroscience Research Australia; Department of Neurology (M.C.K.), Royal Prince Alfred Hospital; ARC Centre of Excellence in Cognition and its Disorders (J.R.H., O.P.); and Division of Neuroscience (B.G.), Garvan Institute of Medical Research and St Vincent's Clinical School, UNSW Sydney, New South Wales, Australia.

Objective: To assess the incidence, heritability, and neuropathology of primary progressive aphasia (PPA) with amyotrophic lateral sclerosis (ALS) in a large Australian cohort.

Methods: A total of 130 patients with a primary nonfluent variant of PPA (nfvPPA) or semantic variant of PPA (svPPA) were assessed for concomitant ALS and a strong family history of neurodegenerative diseases (Goldman score ≤3). Neuropathologic examination was carried out in 28% (n = 36) of these PPA and PPA-ALS cases that had come to autopsy. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007146DOI Listing
February 2019
1 Read

Vitamin D: A novel protective factor for delirium?

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Unit of Cardiovascular and Nutritional Epidemiology (S.C.L.), Institute of Environmental Medicine, Karolinska Institutet, Stockholm; Department of Surgical Sciences (S.C.L.), Uppsala University, Sweden; and Medical School (L.F.), University of Western Australia, Perth.

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http://dx.doi.org/10.1212/WNL.0000000000007121DOI Listing
February 2019

Enlightened PD: A novel treatment for Parkinson disease?

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Neurology (A.V.), Massachusetts General Hospital, Harvard Medical School, Boston; and Neuropsychology Section (L.M.), Departments of Psychiatry and Neurology, University Hospital of Patras, University of Patras Medical School, Rio, Greece.

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http://dx.doi.org/10.1212/WNL.0000000000007078DOI Listing
February 2019
1 Read

Bright light therapy for depression in Parkinson disease: A randomized controlled trial.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From Amsterdam UMC (S.R., C.V., J.H.S., E.J.W.v.S., A.W.H., O.A.v.d.H.), Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience; Department of Research and Innovation (S.R., J.H.S., A.W.H., O.A.v.d.H.), GGZ InGeest; Amsterdam UMC (C.V., H.W.B., Y.D.v.d.W.), Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience; Amsterdam UMC (H.W.B.), Vrije Universiteit Amsterdam, Department of Neurology, Amsterdam Neuroscience; Department of Sleep and Cognition (E.J.W.v.S., Y.D.v.d.W.), Netherlands Institute for Neuroscience; Department of Integrative Neurophysiology (E.J.W.v.S.), Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University; and Amsterdam UMC (J.W.T.), Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam, the Netherlands.

Objective: To assess the efficacy of bright light therapy (BLT) in reducing depressive symptoms in patients with Parkinson disease (PD) and major depressive disorder (MDD) compared to a control light.

Methods: In this double-blind controlled trial, we randomized patients with PD and MDD to treatment with BLT (±10,000 lux) or a control light (±200 lux). Participants were treated for 3 months, followed by a 6-month naturalistic follow-up. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007090DOI Listing
February 2019