6,600 results match your criteria Neurological Sciences[Journal]


The predictive dysphagia score (PreDyScore) in the short- and medium-term post-stroke: a putative tool in PEG indication.

Neurol Sci 2019 Apr 19. Epub 2019 Apr 19.

Unità Operativa Dietetica e Nutrizione Clinica, IRCCS per l'Oncologia e la Neurologia, Ospedale Policlinico San Martino, Genoa, Italy.

Purpose: We performed an evaluation of dysphagia in an unselected series of strokes to identify factors causing persisting dysphagia at 1 month after onset and to formulate a predictive score.

Methods: We evaluated the association between dysphagia and clinical aspects (univariate analysis) at the 7th and 30th days after admission. We performed a multivariate logistic regression at the 30th day on the factors that were significant. Read More

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http://dx.doi.org/10.1007/s10072-019-03896-2DOI Listing

Carrier frequency of spinal muscular atrophy in Thailand.

Neurol Sci 2019 Apr 19. Epub 2019 Apr 19.

Department of Internal Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Spinal muscular atrophy (SMA) is one of the leading causes of death in infants and young children from heritable diseases. Patients diagnosed with SMA develop symmetrical progressive muscle weakness and atrophy from degeneration of alpha motor neurons. Approximately 95% of patients have a homozygous deletion of survival motor neuron 1 (SMN1) gene in exon 7 and inherited in autosomal recessive pattern. Read More

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http://link.springer.com/10.1007/s10072-019-03885-5
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http://dx.doi.org/10.1007/s10072-019-03885-5DOI Listing
April 2019
1 Read

Causes of chronic neuropathies: a single-center experience.

Neurol Sci 2019 Apr 18. Epub 2019 Apr 18.

Unit of Neurology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, via Álvaro del Portillo, 21, 00128, Rome, Italy.

Objectives: Chronic neuropathies are a common cause of neurological disability worldwide. However, few reports have evaluated, in real life, the prevalence of the several conditions which can cause it.

Patients And Methods: The authors reviewed informatic database for outpatient office to confirm identification of chronic neuropathy in a 3-year interval period. Read More

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http://link.springer.com/10.1007/s10072-019-03899-z
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http://dx.doi.org/10.1007/s10072-019-03899-zDOI Listing
April 2019
3 Reads

A complex relation between depression and multiple sclerosis: a descriptive review.

Neurol Sci 2019 Apr 18. Epub 2019 Apr 18.

IRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113 Via Palermo, C.da Casazza, 98124, Messina, Italy.

Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease that affects central nervous system (CNS). MS patients are more likely to develop depressive symptoms than patients with other chronic diseases.

Objective: In this review, we have analysed if there is a correlation between brain lesions (BL), structural damage (SD) and depressive symptoms (DS). Read More

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http://link.springer.com/10.1007/s10072-019-03889-1
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http://dx.doi.org/10.1007/s10072-019-03889-1DOI Listing
April 2019
1 Read

Tonic pupils: an unusual autonomic involvement in chronic inflammatory demyelinating polyneuropathy (CIDP).

Neurol Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, São Paulo, SP, 04039-002, Brazil.

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neuropathy which affects mainly large myelinated axons and has a typically mild autonomic dysfunction mainly from postganglionic nerve fiber involvement.

Case Report: We report here an acute onset CIDP initially diagnosed as Guillain-Barré syndrome (GBS), unresponsive to treatment with intravenous immunoglobulin (IVIg), which later responded to plasmapheresis and corticoids. The patient had a markedly distal demyelination, prominent cranial nerve involvement and, interestingly, bilateral fixed dilated pupils. Read More

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http://dx.doi.org/10.1007/s10072-019-03890-8DOI Listing
April 2019
1 Read

Sexual abuse and psychogenic nonepileptic seizures.

Neurol Sci 2019 Apr 14. Epub 2019 Apr 14.

Neuroscience Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: We investigated the frequency of reported sexual abuse in patients with psychogenic nonepileptic seizures (PNES) in a Middle-Eastern culture (Iran) and tried to characterize the association between a history of sexual abuse and the clinical characteristics of PNES in these patients.

Methods: In this retrospective database study, patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 until 2018, were studied. Patients were categorized into two groups: (1) those with a history of sexual abuse and (2) those without such a history. Read More

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http://dx.doi.org/10.1007/s10072-019-03887-3DOI Listing
April 2019
1 Read

Sixth cranial nerve palsy and ipsilateral segmental carotid arteritis after tooth alveolectomy.

Neurol Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurology, University Hospital Centre Zagreb, School of Medicine, Referral Centre of the Ministry of Health of the Republic of Croatia for Intensive Neurology and Endovascular Treatment of Stroke and Vascular Malformations of the Central Nervous System, University of Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.

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http://dx.doi.org/10.1007/s10072-019-03888-2DOI Listing

On the central role of mitochondria dysfunction and oxidative stress in Alzheimer's disease.

Neurol Sci 2019 Apr 13. Epub 2019 Apr 13.

Johns Hopkins University, Baltimore, MD, USA.

Background: Alzheimer's disease (AD) is the commonest cause of dementia, with approximately 5 million new cases occurring annually. Despite decades of research, its complex pathophysiology and etiopathogenesis presents a major hindrance to the development of an effective treatment and prevention strategy. Aging is the biggest risk factor for the development of AD, and the total number of older people in the population is going to significantly increase in the next decades, suggesting that AD incidence and prevalence is likely to increase in the future. Read More

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http://dx.doi.org/10.1007/s10072-019-03863-xDOI Listing
April 2019
13 Reads

Cerebrospinal fluid vitamin D-binding protein as a new biomarker for the diagnosis of meningitis.

Neurol Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Gangnam-ro, Jinju-si, Gyeongsangnam-do, 52727, Republic of Korea.

Background: Meningitis is an inflammatory process involving meninges. It is difficult to diagnose because of the absence of a diagnostic biomarker. We first report here the possibility of cerebrospinal fluid (CSF) vitamin D-binding protein (VDBP) as a new biomarker for the diagnosis of meningitis. Read More

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http://dx.doi.org/10.1007/s10072-019-03873-9DOI Listing

The potential roles of aquaporin 4 in amyotrophic lateral sclerosis.

Neurol Sci 2019 Apr 13. Epub 2019 Apr 13.

Computer Center, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China.

Aquaporin 4 (AQP4) is a primary water channel found on astrocytes in the central nervous system (CNS). Besides its function in water and ion homeostasis, AQP4 has also been documented to be involved in a myriad of acute and chronic cerebral pathologies, including autoimmune neurodegenerative diseases. AQP4 has been postulated to be associated with the incidence of a progressive neurodegenerative disorder known as amyotrophic lateral sclerosis (ALS), a disease that targets the motor neurons, causing muscle weakness and eventually paralysis. Read More

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http://link.springer.com/10.1007/s10072-019-03877-5
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http://dx.doi.org/10.1007/s10072-019-03877-5DOI Listing
April 2019
2 Reads

Rivaroxaban in cervical and "cervico-cerebral" artery dissections: a new therapeutic option?

Neurol Sci 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine, Maggiore Hospital, Bologna, BO, Italy.

Antiplatelet agents and vitamin K antagonists (VKA) are usually used in the treatment of cervical (carotid or vertebral) artery dissections (CADs); however, data about the use of direct oral anticoagulants (DOACs) in these conditions are very limited. DOACs have proven to be effective in stroke reduction in non-valvular atrial fibrillation and, when possible, they are preferred to warfarin because of their better safety profile. We describe four cases of CADs and, firstly in literature, cervico-cerebral (CCADs) in young patients (average age of 42 years) treated with rivaroxaban 20 mg daily. Read More

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http://dx.doi.org/10.1007/s10072-019-03882-8DOI Listing
April 2019
2 Reads

Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine.

Neurol Sci 2019 Apr 10. Epub 2019 Apr 10.

Biobanca InterIstituzionale Multidisciplinare, IRCCS San Raffaele Pisana, Rome, Italy.

Dopamine-beta-hydroxylase (DBH) enzyme activity is modulated at the genetic level by the presence of several polymorphisms. Among these, the 19-bp insertion/deletion (I/D) polymorphism (rs72393728/rs141116007) was investigated in several genetic association studies for its correlation with the susceptibility to develop episodic migraine, but conflicting results were achieved. In the present study we analyzed this genetic variant in a carefully characterized population of migraineurs encompassing both episodic and chronic migraine (with and without medication overuse) with the aim to perform a replication study and verify any possible correlation with migraine endophenotypes. Read More

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http://dx.doi.org/10.1007/s10072-019-03865-9DOI Listing

Small-fiber neuropathy definition, diagnosis, and treatment.

Neurol Sci 2019 Apr 9. Epub 2019 Apr 9.

Laboratory of the Mosaic of Autoimmunity, Federal State Budget Educational Institution of Higher Education "St. Petersburg State University", University Emb., 7-9, Saint-Petersburg, Russia, 199034.

In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. Read More

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http://dx.doi.org/10.1007/s10072-019-03871-xDOI Listing
April 2019
1 Read

Effect of taping on scapular kinematics of patients with facioscapulohumeral muscular dystrophy.

Neurol Sci 2019 Apr 9. Epub 2019 Apr 9.

Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.

The aim of this study is to investigate the effects of scapular taping on scapular kinematics by three-dimensional electromagnetic system during shoulder elevation in facioscapulohumeral muscular dystrophy patients. A total of 11 patients with facioscapulohumeral muscular dystrophy were included in the study. Scapular anterior-posterior tilt, upward-downward rotation, and internal-external rotations were evaluated using the three-dimensional electromagnetic system during the elevation of the upper limbs in the scapular plane before and after kinesio taping. Read More

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http://dx.doi.org/10.1007/s10072-019-03846-yDOI Listing

Working memory in posterior cortical atrophy.

Neurol Sci 2019 Apr 8. Epub 2019 Apr 8.

INSERM U 1127, CNRS UMR 7225, Institut du cerveau et de la moelle épinière (ICM), Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France.

We used an ad hoc created neuropsychological battery to evaluate in details both verbal and visuospatial working memory (WM) in patients with posterior cortical atrophy (PCA, n = 5). PCA is a rare, early-onset neurodegenerative dementia, often due to Alzheimer's disease (AD) pathology. Clinically, PCA patients present with visual, visuospatial, and visuomotor deficits, and no memory complaints. Read More

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http://link.springer.com/10.1007/s10072-019-03869-5
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http://dx.doi.org/10.1007/s10072-019-03869-5DOI Listing
April 2019
4 Reads

Dystonin/BPAG1 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis.

Neurol Sci 2019 Apr 8. Epub 2019 Apr 8.

Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan.

Dementia is one of the diabetic complications under intensive study. Alteration of synaptic adhesion protein (SAP) associates with neurological diseases, including Alzheimer's disease. However, the regulation of SAPs in the brain of diabetes mellitus remains elusive. Read More

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http://dx.doi.org/10.1007/s10072-019-03879-3DOI Listing

Clinical characteristics and factors associated with short-term prognosis in adult patients with autoimmune encephalitis of non-neoplastic etiology.

Neurol Sci 2019 Apr 7. Epub 2019 Apr 7.

Department of Neurology, Shengjing Hospital, China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, People's Republic of China.

Background: Reports that autoimmune encephalitis (AE) is associated with antibodies have increased; however, little is known about the distribution of clinical symptoms, imaging changes, and prognostic factors in patients with AE of non-neoplastic etiology. Accordingly, we evaluated the clinical characteristics and factors associated with short-term prognosis.

Methods: From January 2016 to June 2018, 31 adult patients were diagnosed with AE of non-neoplastic etiology at Shengjing Hospital of China Medical University and their demographic and clinical characteristics were abstracted. Read More

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http://dx.doi.org/10.1007/s10072-019-03883-7DOI Listing
April 2019
3 Reads

KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment.

Neurol Sci 2019 Apr 5. Epub 2019 Apr 5.

Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

KIBRA is a signal transducer protein, mainly expressed in the kidney and brain. A single-nucleotide polymorphism (SNP rs17070145, T → C exchange) has been linked to different cognitive function. In 2008, we studied 70 subjects who complained of subjective cognitive decline (SCD) and found that CT/TT carriers performed worse than CC carriers on a long-term memory test. Read More

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http://dx.doi.org/10.1007/s10072-019-03866-8DOI Listing
April 2019
2 Reads

Correction to: Normative values of the Rao's Brief Repeatable Battery in an Italian young adolescent population: the influence of age, gender, and education.

Neurol Sci 2019 Apr 5. Epub 2019 Apr 5.

Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Via Sergio Pansini, 5 - Building 17, Ground floor, Naples, Italy.

The published version of this article unfortunately contained a mistake in Table 2. Read More

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http://dx.doi.org/10.1007/s10072-019-03880-wDOI Listing
April 2019
2 Reads

One-year single-center experience with the Aperio thrombectomy device in large vessel occlusion in the anterior circulation: safety, efficacy, and clinical outcome.

Neurol Sci 2019 Apr 4. Epub 2019 Apr 4.

Medical Faculty, Department of Diagnostic and Interventional Radiology, University Duesseldorf, Moorenstr.5, 40225, Duesseldorf, Germany.

Background And Purpose: The Aperio thrombectomy device (Aperio) is a stent retriever designed to achieve rapid and substantial flow restoration in acute ischemic stroke due to large-vessel occlusions (LVOs). We evaluated the safety and efficacy of the Aperio device and compared it with published data of established stent retrievers.

Methods: We retrospectively analyzed institutional data of consecutive stroke procedures in patients with LVO in the anterior circulation that were treated between January 2017 and December 2017 with the Aperio. Read More

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http://dx.doi.org/10.1007/s10072-019-03861-zDOI Listing
April 2019
1 Read

Correction to: A review of electrophysiological studies of lower motor neuron involvement in amyotrophic lateral sclerosis.

Neurol Sci 2019 Apr 3. Epub 2019 Apr 3.

Canadian Neurological Center, Mississauga, ON, Canada.

The published version of this article unfortunately contained a mistake. The sequence of authorship and the corresponding author is incorrect. The correct sequence and corresponding author is presented here. Read More

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http://dx.doi.org/10.1007/s10072-019-03876-6DOI Listing
April 2019
1 Read

Incidence and prevalence of Parkinson's disease in the Italian region of Umbria: a population-based study using healthcare administrative databases.

Neurol Sci 2019 Apr 3. Epub 2019 Apr 3.

Neurology Clinic, University of Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.

Parkinson's disease is known to pose a significant burden on society in industrialized countries. However, few studies have been conducted in Italy using administrative healthcare databases for epidemiological purposes. We wanted to estimate the incidence and prevalence rates of Parkinson's disease in the Italian region of Umbria by means of linkage between several sources of administrative healthcare data: hospitalization episodes, exemptions from medical charges, drug prescriptions from general practitioners and physicians working in the public sector. Read More

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http://dx.doi.org/10.1007/s10072-019-03872-wDOI Listing

Cluster headache: insights from resting-state functional magnetic resonance imaging.

Neurol Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Neuroradiology, IRCCS Fondazione Istituto Neurologico 'Carlo Besta', 20133, Milan, Italy.

The comprehension of cluster headache (CH) has greatly benefited from the tremendous progress of the neuroimaging techniques over the last 20 years. Since the pioneering study of May et al. (1998), the neuroimaging results have indeed revolutionized the conception of this disease, now considered as a dysfunction of the central nervous system. Read More

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http://dx.doi.org/10.1007/s10072-019-03874-8DOI Listing
April 2019
5 Reads

A Delphi consensus statement of the Neuropathic Pain Special Interest Group of the Italian Neurological Society on pharmacoresistant neuropathic pain.

Neurol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Human Neuroscience, University Sapienza, Viale Università 30, 00185, Rome, Italy.

To improve patient care and help clinical research, the Neuropathic Pain Special Interest Group of the Italian Neurological Society appointed a task force to elaborate a consensus statement on pharmacoresistant neuropathic pain. The task force included 19 experts in neuropathic pain. These experts participated in a Delphi survey consisting of three consecutive rounds of questions and a face-to-face meeting, designed to achieve a consensus definition of pharmacoresistant neuropathic pain. Read More

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http://dx.doi.org/10.1007/s10072-019-03870-yDOI Listing
April 2019
1 Read

Emotional consciousness preserved in patients with disorders of consciousness?

Neurol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurology & Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.

Increasing evidence from studies of brain responses to subject's own name (SON) indicates that residual consciousness is preserved in patients with disorders of consciousness (DOC) and that specific network activation might provide evidence of consciousness. However, it remains unclear whether SON is suitable for detection of emotional consciousness; moreover, the particular aspects of brain network organization that are critical for consciousness are unknown. The present study used an innovative approach to explore affective consciousness in patients with DOC during emotional stimuli. Read More

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http://link.springer.com/10.1007/s10072-019-03848-w
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http://dx.doi.org/10.1007/s10072-019-03848-wDOI Listing
April 2019
5 Reads

Adherence to recommendations and clinical outcomes of patients hospitalized for stroke: the role of the admission ward-a real-life investigation from Italy.

Neurol Sci 2019 Apr 2. Epub 2019 Apr 2.

National Centre for Healthcare Research & Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy.

Objective: To determine whether out-of-hospital healthcare and adverse outcomes are better in stroke patients admitted to a neurology ward compared with those admitted to general wards.

Methods: Beneficiaries of the National Health Service from the Italian Lombardy Region who were discharged alive after hospital admission during the year 2009 for ischemic stroke (9776 patients) or intracerebral or subarachnoid hemorrhage (1102 patients) entered into the cohort and were followed until 2012. Exposure of interest was the ward type where inpatients were admitted (neuro vs. Read More

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http://link.springer.com/10.1007/s10072-019-03867-7
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http://dx.doi.org/10.1007/s10072-019-03867-7DOI Listing
April 2019
6 Reads

Combined hypertrophic olivary degeneration and Wallerian degeneration of the bilateral middle cerebellar peduncles: a case report.

Neurol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

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http://dx.doi.org/10.1007/s10072-019-03858-8DOI Listing
April 2019
1 Read

Convexal subarachnoid hemorrhage and acute ischemic stroke: a border zone matter?

Neurol Sci 2019 Apr 2. Epub 2019 Apr 2.

Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70100, Bari, Italy.

Background: Convexal subarachnoid hemorrhage (c-SAH) is an infrequent condition with variable causes. c-SAH concomitant to acute ischemic stroke (AIS) is even less frequent, and the relationship between the two conditions remains unclear.

Methods: Between January 2016 and January 2018, we treated four patients who were referred to our stroke unit with ischemic stroke and concomitant nontraumatic c-SAH. Read More

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http://dx.doi.org/10.1007/s10072-019-03868-6DOI Listing
April 2019
2 Reads

Complex multisystem phenotype associated with the mitochondrial DNA m.5522G>A mutation.

Neurol Sci 2019 Apr 1. Epub 2019 Apr 1.

Molecular Medicine for Neurodegenerative and Neuromuscular Diseases Unit, IRCCS Stella Maris Foundation, via dei Giacinti 2, 56128, Pisa, Italy.

Mitochondrial tRNAs are responsible for more than half of pathogenic point mutations in the mitochondrial genome (mtDNA). Different mutations give rise to widely differing phenotypes, ranging from isolated organ-specific diseases to multisystem conditions. Herein, we report a 40-year-old woman presenting with a complex multisystem phenotype including sensorineural hearing loss, retinopathy, severe dilated cardiomyopathy, non-insulin dependent diabetes mellitus, and renal failure. Read More

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http://link.springer.com/10.1007/s10072-019-03864-w
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http://dx.doi.org/10.1007/s10072-019-03864-wDOI Listing
April 2019
9 Reads

Analysis of characteristics affecting instrumental activities of daily living in Parkinson's disease patients without dementia.

Neurol Sci 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 58128, South Korea.

Patients with Parkinson's disease (PD) are liable to experience impairment in their activities of daily living (ADL), which include ambulating, eating, dressing, bathing, and personal hygiene. The aim of this study is to assess which clinical characteristics contribute significantly to instrumental ADL (IADL) in PD patients without dementia. We included 106 PD patients in our study, and each patient's motor and non-motor status and basic and instrumental ADL were assessed using the appropriate scales. Read More

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http://dx.doi.org/10.1007/s10072-019-03860-0DOI Listing
April 2019
2 Reads

Identification of a novel splice mutation in CTNNB1 gene in a Chinese family with both severe intellectual disability and serious visual defects.

Neurol Sci 2019 Mar 30. Epub 2019 Mar 30.

Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, China.

The CTNNB1 gene encode the β-catenin protein which is a core unit of the cadherin/catenin multiprotein complex. The loss-of-function mutation of the CTNNB1 gene recently has been confirmed as a cause of intellectual disability. Previous studies have found that patients with CTNNB1 gene mutation may have other clinical manifestation such as microcephaly, abnormal facial features, motor and language delays, and mild visual defects. Read More

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http://dx.doi.org/10.1007/s10072-019-03823-5DOI Listing
March 2019
2 Reads

Degenerative and acquired sporadic adult onset ataxia.

Neurol Sci 2019 Mar 29. Epub 2019 Mar 29.

Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.

The diagnosis of sporadic adult onset ataxia is a challenging task since a large collection of hereditary and non-hereditary disorders should be taken into consideration. Sporadic adult onset ataxias include degenerative non-hereditary, hereditary, and acquired ataxias. Multiple system atrophy and idiopathic late cerebellar ataxia are degenerative non-hereditary ataxias. Read More

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http://dx.doi.org/10.1007/s10072-019-03856-wDOI Listing
March 2019
1 Read

Erenumab: from scientific evidence to clinical practice-the first Italian real-life data.

Neurol Sci 2019 Mar 29. Epub 2019 Mar 29.

Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Via della Pisana 235, 00163, Rome, Italy.

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http://dx.doi.org/10.1007/s10072-019-03839-xDOI Listing

Does the migraine attack start in the cortex and is the cortex critical in the migraine process?

Neurol Sci 2019 Mar 29. Epub 2019 Mar 29.

Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Via della Pisana 235, 00163, Rome, Italy.

Migraine is a pure human neurovascular disorder with no reliable corresponding animal model. The cerebral cortex (CC) has long been discussed as a crucial element of its complex mechanism. The present review considers the state of the art of experimental evidence on the involvement of CC in migraine. Read More

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http://dx.doi.org/10.1007/s10072-019-03838-yDOI Listing

When does the brain choose pain?

Neurol Sci 2019 Mar 28. Epub 2019 Mar 28.

Primary Emeritus of the C. Besta Neurological Institute IRCCS Foundation, Milan, Italy.

Why does the brain choose pain? Why does an organ that is able to mask pain, even when intense as in fractures or in fighting wounds, decide to let pain pass and begin conscious, such as that of migraine, when there is no noxa patogena and there is no threat to the integrity of the organism, failing in the main function of pain, that of protection? In this brief review, we retrace the journey that led to the identification of the first complex mechanism of regulation of painful input, the spinal gate control system, through the identification of the predominantly thalamocortical supraspinal centers of the neuromatrix, up to the recognition of a pain matrix extremely articulate and sophisticated that integrates elementary sensations with much more complex functions, related to memory, affectivity, emotion, autonomic self-regulation, and homeostasis systems and so on. Why does the protection system lose its fundamental function in migraine in a behavioral harakiri that periodically damages only itself? This is the challenge facing those dealing with primary headaches in the next future: why migraine? The great strides made in the last decades that have led to the understanding of complex pathogenetic mechanisms risk remaining orphans if we fail to identify the primum movens at the base of one of the most common pathologies in the human race. Read More

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http://dx.doi.org/10.1007/s10072-019-03849-9DOI Listing

Ischemic stroke due to sarcoidosis: the arterial wall enhancement on magnetic resonance imaging.

Authors:
Makoto Kobayashi

Neurol Sci 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurology, Asahi General Hospital, 1326 I, Asahi, Chiba, 289-2511, Japan.

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http://dx.doi.org/10.1007/s10072-019-03862-yDOI Listing
March 2019
1 Read

Preliminary design and validation of the "6-K-scale" for bulbar symptoms evaluation in SBMA.

Neurol Sci 2019 Mar 26. Epub 2019 Mar 26.

Neuromuscular Center, Department of Neurosciences, University of Padova, Padua, Italy.

Background: Spinal and bulbar muscular atrophy (SBMA) is a late onset, X-linked neuromuscular disease. Bulbar symptoms are a main characteristic of the disease but a tool for their clinical evaluation still does not exist. The aim of this study was to design and test a new scale (6-K-scale) for evaluation of bulbar function in SBMA. Read More

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http://dx.doi.org/10.1007/s10072-019-03850-2DOI Listing

Behavioral and psychological aspects of cluster headache: an overview.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

Department of Psychology, University of Memphis, 400 Innovation Drive, Memphis, TN, 38152, USA.

This paper overviews available literature addressing behavioral and psychological aspects of cluster headache. Behavioral correlates of sleep and drug use are explored, as are the psychological correlates pertaining to psychopathology and cognitive functioning. We conclude with a review of the few investigations addressing adjunctive behavioral treatments for cluster headache, and provide suggestions for possible ways to enhance effects of behavioral interventions for this painful and difficult to treat headache disorder. Read More

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http://dx.doi.org/10.1007/s10072-019-03831-5DOI Listing

Clinical features of cluster headache in relation to age of onset: results from a retrospective study of a large case series.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

Headache Center, Department of Medicine and Surgery, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1007/s10072-019-03801-xDOI Listing

Imaging the migrainous brain: the present and the future.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurology, IRCCS Ospedale San Raffaele, Vita-salute University, Via Olgettina 48, 20100, Milan, Italy.

In the last 20 years, we observed significant improvements in the use of magnetic resonance imaging (MRI) for the evaluation of patients affected by migraine. Before these technological advances, knowledge of the pathogenesis of migraine was particularly based on clinical assessment. Complementary to clinical evaluation, conventional MRI provides both specific information for differential diagnosis (particularly if cortical or subcortical lesions are detected in the migrainous brain) and unsurpassable opportunities in migraine research. Read More

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http://dx.doi.org/10.1007/s10072-019-03851-1DOI Listing

Sleep disorder-related headaches.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy.

Migraine with and without aura, cluster headache, hypnic headache, and paroxysmal hemicranias are each reported as intrinsically related to sleep. Chronic migraine, chronic tension-type headache, and medication overuse headache may cause sleep disturbance. Otherwise, both headache and sleep disorder may be manifestations of a same systemic dysfunction. Read More

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http://dx.doi.org/10.1007/s10072-019-03837-zDOI Listing
March 2019
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Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

Department of Medicine, Institute of Clinical Sciences, Lund University, Lund, Sweden.

Migraine is a common, severe disease, affecting the brain and blood vessels, causing much pain, time missed from work and family, and severe disability. It affects approximately 12% of most Western populations studied and affects women three times more than men. Cluster headache is a much less common dysfunction of the hypothalamus, involving the sphenopalatine ganglion and other areas; it causes more frequent, shorter, and even more intense pain than migraine. Read More

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http://dx.doi.org/10.1007/s10072-019-03828-0DOI Listing
March 2019
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Chronic migraine and medication overuse: which strategy for a complex scenario.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

Neuroalgology Unit, Headache Center, Neurological Institute "C. Besta" IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy.

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http://dx.doi.org/10.1007/s10072-019-03829-zDOI Listing

Cerebral lipiodol embolism after transarterial hepatic chemoembolization studied with susceptibility-weighted imaging.

Neurol Sci 2019 Mar 23. Epub 2019 Mar 23.

Institution of Radiology at 'University of Study of Campania, Luigi Vanvitelli', piazza Miraglia 2, 80138, Naples, Italy.

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http://dx.doi.org/10.1007/s10072-019-03854-yDOI Listing

Efficacy and safety of deferiprone for the treatment of superficial siderosis: results from a long-term observational study.

Neurol Sci 2019 Mar 22. Epub 2019 Mar 22.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genova, Genoa, Italy.

Background: Superficial siderosis (SS) of the central nervous system is a rare and heterogeneous condition due to deposition of hemosiderin on the surface of the brain and spinal cord. The usually progressive clinical course is characterized by a combination of hearing loss, cerebellar ataxia, and myelopathy. There is no known treatment for SS, but the iron chelator deferiprone (DFP) has been proposed as a potentially useful treatment. Read More

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http://dx.doi.org/10.1007/s10072-019-03847-xDOI Listing

Neuropsychiatric symptoms differently affect mild cognitive impairment and Alzheimer's disease patients: a retrospective observational study.

Neurol Sci 2019 Mar 22. Epub 2019 Mar 22.

Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.

Alzheimer's disease (AD) is the most common form of dementia characterized by the prevalent memory impairment. Mild cognitive impairment (MCI) may represent the early stage of AD, in particular when MCI patients show biomarkers consistent with AD pathology (MCI due to AD). Neuropsychiatric symptoms (NPS) frequently affect both MCI and AD patients. Read More

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http://dx.doi.org/10.1007/s10072-019-03840-4DOI Listing
March 2019
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PON1 is a disease modifier gene in amyotrophic lateral sclerosis: association of the Q192R polymorphism with bulbar onset and reduced survival.

Neurol Sci 2019 Mar 22. Epub 2019 Mar 22.

Department of Neurology - Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano, IRCCS, Piazzale Brescia 20, 20149, Milan, Italy.

Introduction: Previous studies have associated single-nucleotide polymorphisms (SNPs) in the gene encoding the detoxifying enzyme paraoxonase 1 (PON1) to the risk of sporadic ALS. Here, we aimed to assess the role of the coding rs662 (Q192R) SNP as a modifier of ALS phenotype.

Materials And Methods: We genotyped a cohort of 409 patients diagnosed with ALS at our Center between 2002 and 2009 (269 males and 140 females; mean age at onset, 58. Read More

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http://dx.doi.org/10.1007/s10072-019-03834-2DOI Listing
March 2019
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Subacute combined degeneration of the spinal cord is associated with tripterygium glycoside tablet usage.

Neurol Sci 2019 Mar 21. Epub 2019 Mar 21.

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, 45 Changchun St, Xicheng District, Beijing, 100053, China.

Background: Subacute combined degeneration (SCD) is a neurodegenerative disease caused by vitamin B deficiency. The lesions mainly involve the posterior cord, lateral cord, and peripheral nerves. Occasionally, the lesions also involve brain white matter and optic nerves in severe cases. Read More

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http://link.springer.com/10.1007/s10072-019-03845-z
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http://dx.doi.org/10.1007/s10072-019-03845-zDOI Listing
March 2019
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Stress and perceived stigma among parents of children with epilepsy.

Neurol Sci 2019 Mar 22. Epub 2019 Mar 22.

Department of Psychiatric Social Work, National Institute of Mental Health and Neurosciences, Govindswamy Building (2nd Floor), Hosur Road, Near Bangalore Milk Dairy, Landmark: SBI NIMHANS Branch, Bangalore, 560 029, India.

Purpose: The present study aimed at understanding the stress and perceived stigma among parents of children with epilepsy seeking treatment at a tertiary referral center for neurology in South India.

Materials And Methods: Parents of sixty children suffering from epilepsy in the age group of 4-15 years were interviewed to explore parental stress and perceived stigma. They were recruited consecutively over a period of 6 months in 2015. Read More

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http://link.springer.com/10.1007/s10072-019-03822-6
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http://dx.doi.org/10.1007/s10072-019-03822-6DOI Listing
March 2019
4 Reads