6,472 results match your criteria Neurological Sciences[Journal]


Endovascular therapy for acute ischemic stroke: which role for neurologists?

Neurol Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Behavioural and Clinical Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina, 306, Rome, Italy.

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http://dx.doi.org/10.1007/s10072-019-03759-wDOI Listing
February 2019

Intestinal barrier dysfunction following traumatic brain injury.

Neurol Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Critical Care Medicine, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, Xinjiang, China.

Traumatic brain injury (TBI) can cause non-neurological injuries to other organs such as the intestine. Newer studies have shown that paracellular hyperpermeability is the basis of intestinal barrier dysfunction following TBI. Ischemia-reperfusion injury, inflammatory response, abnormal release of neurotransmitters and hormones, and malnutrition contribute to TBI-induced intestinal barrier dysfunction. Read More

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http://dx.doi.org/10.1007/s10072-019-03739-0DOI Listing
February 2019

Benito's neuralgia: the first description of the occipital neuralgia was made for Spanish doctors at the beginning of the nineteenth century.

Neurol Sci 2019 Feb 15. Epub 2019 Feb 15.

Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Avda Ramon y Cajal 3, 47005, Valladolid, Spain.

Background: The occipital neuralgia affects 3 out of every 100,000 people and includes the neuralgia of the greater occipital nerve (GON) and the neuralgia of the minor and third occipital nerves. These nerves emerge from the posterior branches of the first cervical roots, innervate the muscles of the nape, and provide the sensitivity of the scalp. The most frequent issue is not to find causes that justify neuralgia for what is usually idiopathic. Read More

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http://dx.doi.org/10.1007/s10072-019-03734-5DOI Listing
February 2019

Assessing seasonal dynamics of Guillain-Barré syndrome with search engine query data.

Neurol Sci 2019 Feb 14. Epub 2019 Feb 14.

Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 48, 20132, Milan, Italy.

Background And Objective: In previous studies, data deriving from Google Trends showed promising correlation with disease incidence trends assessed with public health control systems. The aim of this work is to use search engine query data to investigate seasonal dynamics in Guillain-Barré syndrome (GBS) in the USA.

Methods: Average Google monthly search volumes for GBS from 2008 to 2017 were analysed for the USA overall and on regional base with generalized estimating equation models. Read More

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http://dx.doi.org/10.1007/s10072-019-03757-yDOI Listing
February 2019

Maternal germline mosaicism in Fabry disease.

Neurol Sci 2019 Feb 14. Epub 2019 Feb 14.

Division of Neurology, Madonna del Soccorso Hospital, AV5, San Benedetto del Tronto, Italy.

Fabry disease (FD) is an X-linked monogenic disorder caused by mutations in the GLA gene which leads to a deficiency of the functionally active lysosomal α-galactosidase A enzyme. Here, we report on a family of five members: unaffected parents, one unaffected son, and another son and daughter both carrying the same mutation (p.G138E) in the GLA gene. Read More

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http://dx.doi.org/10.1007/s10072-019-03754-1DOI Listing
February 2019

Methylation of cation-chloride cotransporters NKCC1 and KCC2 in patients with juvenile myoclonic epilepsy.

Neurol Sci 2019 Feb 13. Epub 2019 Feb 13.

Faculty of Medicine Department of Neurology and Clinical Neurophysiology, Muğla Sıtkı Koçman University, Muğla, Turkey.

The etiology of juvenile myoclonic epilepsy (JME) is still unknown and the process of elaboration of multiple genetic mechanisms is ongoing. The aim of this study was to investigate the potential role of NKCC1 (SCL12A2) and KCC2 (SCL12A5) in JME by comparing their DNA methylation status in patients with JME versus healthy controls. Forty-nine patients with JME and 39 healthy individuals were compared for DNA methylation at the 5CpG islands. Read More

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http://dx.doi.org/10.1007/s10072-019-03743-4DOI Listing
February 2019

Stroke during sleep and obstructive sleep apnea: there is a link.

Neurol Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, King Saud University, Riyadh, Saudi Arabia.

Objectives: The onset of ischemic stroke symptoms has been established to have a diurnal variation, with a sizeable proportion (8-28%) occurring during sleep. Obstructive sleep apnea (OSA) has been established as an important risk factor for ischemic stroke. However, data on the relationship between OSA and wake-up stroke (WUS) has been scarce. Read More

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http://dx.doi.org/10.1007/s10072-019-03753-2DOI Listing
February 2019

Source localization of epileptiform discharges in childhood absence epilepsy using a distributed source model: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.

Neurol Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Localizing the source of epileptiform discharges in generalized epilepsy has been controversial for the past few decades. Recent neuroimaging studies have shown that epileptiform discharges in generalized epilepsy can be localized to a particular region. Childhood absence epilepsy (CAE) is the most common generalized epilepsy in childhood and is considered the prototype of idiopathic generalized epilepsy (IGE). Read More

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http://dx.doi.org/10.1007/s10072-019-03751-4DOI Listing
February 2019

Association of uric acid with stenosis of intracranial and extracranial arteries in elderly patients with cerebral infarction.

Neurol Sci 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, Second Affiliated Hospital of Fujian Medical University, Zhongshan North Road 34, Quanzhou, 362000, Fujan, China.

Background: To determine whether uric acid (UA) and intracranial and extracranial atherosclerosis stenosis of elderly patients suffering from ischaemic stroke are inter-related.

Methods: Elderly patients with ischaemic stroke underwent computed tomography angiography (CTA) were enrolled between October 2015 and December 2017. We collected clinical assessment, image data, and laboratory tests, and divided patients into four groups: (1) intracranial stenosis atherosclerosis (ICAS) group, (2) combined intracranial and extracranial atherosclerosis stenosis (COAS) group, (3) extracranial carotid stenosis atherosclerosis (ECAS) group, and (4) non-cerebral stenosis atherosclerosis (NCAS) group. Read More

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http://dx.doi.org/10.1007/s10072-019-03737-2DOI Listing
January 2019
1 Read

Attenuation of ALS progression during pregnancy-lessons to be learned or just a coincidence?

Neurol Sci 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Clinical Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.

ALS is the most frequent motor neuron disorder in adults with suggested complex relationship regarding gender. Studies investigating ALS and hormones have provided varying results. ALS onset during pregnancy is uncommon and pregnancy after the ALS symptom onset is even rarer. Read More

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http://dx.doi.org/10.1007/s10072-019-03748-zDOI Listing
February 2019

Efficacy of ultrasound-guided suprascapular nerve block treatment in patients with painful hemiplegic shoulder.

Neurol Sci 2019 Feb 9. Epub 2019 Feb 9.

Istanbul Physical Medicine and Rehabilitation Training and Research Hospital, Istanbul, Turkey.

Objective: The aim of this study was to evaluate the efficacy of ultrasound-guided suprascapular block treatment in patients with painful hemiplegic shoulder whose pain was not reduced after conservative treatment.

Design: The patients were those whose hemiplegic shoulder pain was not reduced by standard conservative treatment prior to discharge. The study group (n = 21) included patients who had undergone an ultrasound-guided suprascapular nerve block (SSNB). Read More

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http://dx.doi.org/10.1007/s10072-019-03749-yDOI Listing
February 2019

Accuracy of MDS-UPDRS section IV for detecting motor fluctuations in Parkinson's disease.

Neurol Sci 2019 Feb 9. Epub 2019 Feb 9.

Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.

Background: In a precedent paper, we validated part IV of the Unified Parkinson's Disease Rating Scale (UPDRS) for detecting motor fluctuations in Parkinson's Disease (PD) patients using a 12-h Waking-Day Motor Assessment (WDMA) as gold standard, showing a high sensitivity (> 80%) and a lower specificity (< 45%). The aim of this study was to validate the Movement Disorder Society-UPDRS (MDS-UPDRS) part IV, especially items 4.3 and 4. Read More

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http://dx.doi.org/10.1007/s10072-019-03745-2DOI Listing
February 2019
1 Read

Mutations in the SPAST gene causing hereditary spastic paraplegia are related to global topological alterations in brain functional networks.

Neurol Sci 2019 Feb 8. Epub 2019 Feb 8.

Institute of Applied Sciences and Intelligent Systems, CNR, Pozzuoli, Italy.

Aim: Our aim was to describe the rearrangements of the brain activity related to genetic mutations in the SPAST gene.

Methods: Ten SPG4 patients and ten controls underwent a 5 min resting state magnetoencephalography recording and neurological examination. A beamformer algorithm reconstructed the activity of 90 brain areas. Read More

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http://dx.doi.org/10.1007/s10072-019-3725-yDOI Listing
February 2019

Peculiar EEG signatures, ictal drinking and long-term follow-up in anti-LGI1 encephalitis.

Neurol Sci 2019 Feb 7. Epub 2019 Feb 7.

Clinical Neurology Unit, Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia, 15, 33010, Udine, Italy.

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http://dx.doi.org/10.1007/s10072-019-3729-7DOI Listing
February 2019

A rare case of pure sensitive Parsonage-Turner syndrome.

Neurol Sci 2019 Feb 7. Epub 2019 Feb 7.

Neurology Clinic, Azienda Ospedaliero Universitaria Santa Maria della Misericordia, Udine, Italy.

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http://dx.doi.org/10.1007/s10072-019-03747-0DOI Listing
February 2019

A multimodal imaging features of the brain in adult-onset neuronal intranuclear inclusion disease.

Neurol Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, Foshan Hospital Affiliated to Sun Yat-sen University, No. 81, Lingnan North Road, Foshan, 528000, Guangdong, China.

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http://dx.doi.org/10.1007/s10072-019-03742-5DOI Listing
February 2019

Recumbent stepping aerobic exercise in amyotrophic lateral sclerosis: a pilot study.

Neurol Sci 2019 Feb 4. Epub 2019 Feb 4.

Brain Plasticity Lab, Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, 1919 West Taylor Street, Chicago, IL, 60612, USA.

Objectives: Aerobic exercise can promote neuroplastic responses in the healthy and injured brain. Although the role of exercise in amyotrophic lateral sclerosis (ALS) is debated, new evidence suggests that exercise may reduce disease progression. While common exercise modalities such as the treadmill and cycle ergometer have been explored in ALS, the safety and feasibility of a total body recumbent stepper have not been investigated. Read More

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http://link.springer.com/10.1007/s10072-019-03736-3
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http://dx.doi.org/10.1007/s10072-019-03736-3DOI Listing
February 2019
4 Reads

Plasma alpha-synuclein levels in patients with Parkinson's disease: a systematic review and meta-analysis.

Neurol Sci 2019 Feb 4. Epub 2019 Feb 4.

Neurochemistry laboratory, 1st Department of Neurology and Movement Disorders, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, 72-74 Vasilissis Sofias Avenue, 11528, Athens, Greece.

Objective: To date, there are no definitive biomarkers for diagnose Parkinson's disease (PD). The detection of α-synuclein (α-Syn) in plasma of PD patients has yielded promising but inconclusive results. To determine the performance of α-Syn as a diagnostic biomarker of PD, we used a meta-analysis. Read More

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http://dx.doi.org/10.1007/s10072-019-03738-1DOI Listing
February 2019

Withdrawal from acute medication normalises short-term cortical synaptic potentiation in medication overuse headache.

Neurol Sci 2019 Feb 1. Epub 2019 Feb 1.

Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome Polo Pontino, Corso della Repubblica 79, 04100, Latina, Italy.

Objectives: To study the effects of a standard acute medication withdrawal program on short-term cortical plasticity mechanisms in patients with medication overuse headache (MOH).

Methods: Thirteen patients with MOH and 16 healthy volunteers underwent repetitive transcranial magnetic stimulation (rTMS) over the left motor cortex; in patients with MOH, recordings were performed before and after a 3-week medication withdrawal program. Ten trains of 10 stimuli each (120% resting motor threshold) were delivered at 1 Hz or 5 Hz in two separate sessions in a randomised order. Read More

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http://dx.doi.org/10.1007/s10072-019-03735-4DOI Listing
February 2019
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Uremia presented as acute cranial neuropathy.

Neurol Sci 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurology, Chonbuk National University Medical School, Jeonju, 54907, South Korea.

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http://link.springer.com/10.1007/s10072-019-03741-6
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http://dx.doi.org/10.1007/s10072-019-03741-6DOI Listing
February 2019
2 Reads

Diagnostic performance of DWI for differentiating primary central nervous system lymphoma from glioblastoma: a systematic review and meta-analysis.

Neurol Sci 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurosurgery, Second Affiliated Hospital, Zhejiang University School of Medicine, NO.88 Jiefang Rd, Zhejiang, 310009, Hangzhou, China.

Objective: The purpose of this meta-analysis was to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) for differentiating primary central nervous system lymphoma (PCNSL) from glioblastoma (GBM).

Materials And Methods: A thorough search of the databases including PubMed, EMBASE, and Cochrane Library was carried out and the data acquired were up to November 1, 2017. The quality of the studies involved was evaluated using QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies, revised version). Read More

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http://dx.doi.org/10.1007/s10072-019-03732-7DOI Listing
January 2019
1 Read

Methylphenidate modifies activity in the prefrontal and parietal cortex accelerating the time judgment.

Neurol Sci 2019 Jan 28. Epub 2019 Jan 28.

Neuro-innovation Technology and Brain Mapping Laboratory, Federal University of Piauí, Av. São Sebastião, 2819, Bairro São Benedito, Parnaíba, Piauí, CEP: 64202-020, Brazil.

Methylphenidate produces its effects via actions on cortical areas involved with attention and working memory, which have a direct role in time estimation judgment tasks. In particular, the prefrontal and parietal cortex has been the target of several studies to understand the effect of methylphenidate on executive functions and time interval perception. However, it has not yet been studied whether acute administration of methylphenidate influences performance in time estimation task and the changes in alpha band absolute power in the prefrontal and parietal cortex. Read More

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http://dx.doi.org/10.1007/s10072-018-3699-1DOI Listing
January 2019

Effects of fluoroscopy-guıded intraartıcular injectıon, suprascapular nerve block, and combınatıon therapy ın hemıplegıc shoulder paın: a prospective double-blınd, randomızed clınıcal study.

Neurol Sci 2019 Jan 28. Epub 2019 Jan 28.

Department of Physical Medicine and Rehabilitation, Division of Pain Medicine, Faculty of Medicine, Marmara University, Mimar Sinan Caddesi No:41 Üst Kaynarca Fevzi Çakmak Mahallesi Pendik, Postal code 34906, Istanbul, Turkey.

Objective: To investigate the effect and superiority of fluoroscopy-guided intraarticular shoulder injection (IAI), suprascapular nerve block (SSNB), and combination treatment in hemiplegic shoulder pain (HSP).

Design: We included 30 patients diagnosed with HSP. Patients were divided into three groups: IAI, SSNB, and combination treatment. Read More

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http://dx.doi.org/10.1007/s10072-019-03733-6DOI Listing
January 2019
1 Read

Pictures portrayed by children with migraine with aura: a Turkish case series.

Neurol Sci 2019 Jan 28. Epub 2019 Jan 28.

Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, Child Psychiatry Department, University of Health Sciences, Ankara, Turkey.

Background: Migraine is one of the most debilitating disorders with its chronic nature seen in childhood characterized by episodic bilateral or unilateral throbbing pain on the head that strikes at any time. It is divided into two categories as with or without aura and is diagnosed according to the 2013 International Headache Society criteria.

Aim And Method: This study aims to present the pictures depicted by adolescents aged 14-18 who were diagnosed with migraine with visual aura by Ankara Training and Research Hospital Child Neurology Department. Read More

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http://dx.doi.org/10.1007/s10072-019-3713-2DOI Listing
January 2019
3 Reads

Efficacy and safety of prothrombin complex concentrate for vitamin K antagonist-associated intracranial hemorrhage: a systematic review and meta-analysis.

Neurol Sci 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, Guangdong, China.

Background: Prothrombin complex concentrate (PCC) is the treatment of choice in vitamin K antagonist-associated intracranial hemorrhage (VKA-ICH). However, the efficiency and safety associated with their use remain unclear.

Aims: This study aimed to assess the current evidence of the clinical outcomes in patients with VKA-ICH treated with or without PCC. Read More

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http://dx.doi.org/10.1007/s10072-019-3726-xDOI Listing
January 2019

Late-onset and fast progressive neuropathy and cardiomyopathy in Val32Ala transthyretin gene mutation.

Neurol Sci 2019 Jan 26. Epub 2019 Jan 26.

Neuroalgology Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria, 11, 20133, Milan, Italy.

More than 100 mutations of the transthyretin gene have been reported in autosomal dominant familial amyloid polyneuropathy. This rare disease causes severe motor and sensory disability, dysautonomia, and in some patients also cardiomyopathy. The diagnosis can be challenging mainly in sporadic adult patients showing clinical, laboratory, and neurophysiological findings overlapping other forms of chronic neuropathy. Read More

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http://dx.doi.org/10.1007/s10072-019-3716-zDOI Listing
January 2019

Autoimmune autonomic ganglionopathy associated with monoclonal gammopathy of undetermined significance: a case report.

Neurol Sci 2019 Jan 26. Epub 2019 Jan 26.

Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori, 030-8551, Japan.

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http://dx.doi.org/10.1007/s10072-019-3731-0DOI Listing
January 2019

Expression analysis of long non-coding RNAs and their target genes in multiple sclerosis patients.

Neurol Sci 2019 Jan 24. Epub 2019 Jan 24.

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, PO Box 1985717443, Tehran, Iran.

Multiple sclerosis (MS) is a progressive chronic autoimmune-mediated disease. Recently, long non-coding RNAs (lncRNAs) are characterized to participate in the adjustment of immune responses. Here, we evaluated the expression levels of GSTT1-AS1 and IFNG-AS1 lncRNAs and their targets (TNF and IFNG, respectively) in Iranian MS patients. Read More

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http://dx.doi.org/10.1007/s10072-019-3720-3DOI Listing
January 2019

Comprehensive risk factor evaluation of postoperative delirium following major surgery: clinical data warehouse analysis.

Neurol Sci 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7, Keunjaebong-gil, Hwaseong, Gyeonggi-do, 18450, Republic of Korea.

Background: Postoperative delirium (POD) in older adults is a very serious complication. Due to the complexity of too many risk factors (RFs), an overall assessment of RFs may be needed. The aim of this study was to evaluate comprehensively the RFs of POD regardless of the organ undergoing operation, efficiently incorporating the concept of comprehensive big data using a smart clinical data warehouse (CDW). Read More

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http://link.springer.com/10.1007/s10072-019-3730-1
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http://dx.doi.org/10.1007/s10072-019-3730-1DOI Listing
January 2019
2 Reads

Headache, chest pain, and multiplex cranial neuropathy.

Neurol Sci 2019 Jan 23. Epub 2019 Jan 23.

Neuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1007/s10072-019-3718-xDOI Listing
January 2019

Protective effects of CX3CR1 on autoimmune inflammation in a chronic EAE model for MS through modulation of antigen-presenting cell-related molecular MHC-II and its regulators.

Neurol Sci 2019 Jan 23. Epub 2019 Jan 23.

Department of Laboratory Science, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.

Background: Recent evidences have implicated neuroprotective effects of CX3CR1 in multiple sclerosis (MS). But whether CX3CR1 is involved in modulation of antigen-presenting cell (APC)-related molecular MHC-II and what the possible mechanism is remain unidentified.

Objective: In this study, we intended to investigate the effects of CX3CR1 on MHC-II expressions on brain myeloid cells in experimental autoimmune encephalomyelitis (EAE) mice and explore the possible regulators for it. Read More

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http://dx.doi.org/10.1007/s10072-019-3721-2DOI Listing
January 2019

Typical clinical and imaging manifestations of encephalitis with anti-γ-aminobutyric acid B receptor antibodies: clinical experience and a literature review.

Neurol Sci 2019 Jan 22. Epub 2019 Jan 22.

Department of Emergency, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, No.16766 Jingshi Road, Lixia District, Jinan, 250014, Shandong, China.

Objective: To explore the clinical, imaging, and electroencephalogram (EEG) findings, as well as the treatment and prognosis of five patients with anti-γ-aminobutyric acid B receptor (GABAR) encephalitis and review the current literature to gain a deeper understanding and improve the clinical diagnostic ability of the disease.

Methods: Clinical data such as blood examination, imaging, computed tomography (CT), EEG, and magnetic resonance imaging (MRI) findings from five patients with anti-GABAR encephalitis were retrospectively analyzed.

Results: Based on the imaging data, autoimmune encephalitis with anti-GABAR antibodies displayed subacute onset of episodic memory loss, seizures, and confusion, in addition to signal changes in the medial temporal lobe and/or hippocampus. Read More

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http://dx.doi.org/10.1007/s10072-018-3679-5DOI Listing
January 2019
2 Reads

Body image in multiple sclerosis patients: a descriptive review.

Neurol Sci 2019 Jan 22. Epub 2019 Jan 22.

IRCCS Centro Neurolesi "Bonino Pulejo", S.S. 113 Via Palermo, C.da Casazza, 98124, Messina, Italy.

Objective: Multiple sclerosis is a neurological disorder-may in some patients have impact on body image; this could contribute to neurological disability, psychological distress, and can reduce quality of life. This review has been conducted on studies investigating the representation of body image.

Method: We have researched PubMed and Web of Science databases and included screening references for studies and review articles about this topic. Read More

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http://dx.doi.org/10.1007/s10072-019-3722-1DOI Listing
January 2019
3 Reads

Report on a child with neurofibromatosis type 2 and unilateral moyamoya: further evidence of cerebral vasculopathy in NF2.

Neurol Sci 2019 Jan 21. Epub 2019 Jan 21.

Referral Centre of Neurofibromatosis, Department of Woman and Child, Specialistic and General Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Via L. De Crecchio 4, 80138, Naples, Italy.

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http://dx.doi.org/10.1007/s10072-019-3728-8DOI Listing
January 2019
1 Read

Dementia: new vistas and opportunities.

Neurol Sci 2019 Jan 21. Epub 2019 Jan 21.

Department of Clinical Neurological Sciences, Western University, 339 Windermere Road, London, Ontario, N6A 5A5, Canada.

Over the past four decades, Alzheimer disease has become near synonymous with dementia and the amyloid/tau hypothesis as its dominant explanation. However, this monorail approach to etiology has failed to yield a single disease-modifying drug. Part of the explanation stems from the fact that most dementias in the elderly result from interactive Alzheimer and cerebrovascular pathologies. Read More

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http://dx.doi.org/10.1007/s10072-019-3714-1DOI Listing
January 2019

Post-lumbar puncture headache: an adverse effect in multiple sclerosis work-up.

Neurol Sci 2019 Jan 21. Epub 2019 Jan 21.

Neurology Unit, Department of Translational Medicine, AOU Maggiore della Carità and University of Piemonte Orientale, Novara, Italy.

Background: Lumbar puncture (LP) is a safe procedure commonly performed in the diagnostic work-up of multiple sclerosis (MS), and its main adverse event is post-LP headache (PLPH). Predictors for PLPH in MS are not established.

Aims: To describe the occurrence of, and, factors related to PLPH in patients with suspected MS, studied on a daily-basis admission. Read More

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http://dx.doi.org/10.1007/s10072-019-3724-zDOI Listing
January 2019
1 Read

What is the role of diffusion tensor imaging (DTI) in detecting subclinical pyramidal tract dysfunction in Behçet's and neuro-Behçet's cases?

Neurol Sci 2019 Jan 19. Epub 2019 Jan 19.

Radiology Department, Ege University Faculty of Medicine, Izmir, Turkey.

The aim of this study is to investigate the pyramidal tract integrity with DTI in Behçet's and neuro-Behçet's cases. We performed this technique in two subgroups of neuro-Behçet's patients (parenchymal and vascular), and Behçet's cases without neurological involvement and control group. Totally, 28 patients were investigated. Read More

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http://dx.doi.org/10.1007/s10072-019-3727-9DOI Listing
January 2019
1 Read

Predicting cerebral edema in ischemic stroke patients.

Neurol Sci 2019 Jan 19. Epub 2019 Jan 19.

Stroke Unit - Medical Department of Continuity of Care and Disability, S.Orsola-Malpighi Hospital, Bologna, Italy.

Objectives: To produce a scoring system for predicting the development of edema in ischemic stroke patients without edema on admission.

Methods: This retrospective study included 572 ischemic stroke patients (73.3 ± 13. Read More

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http://dx.doi.org/10.1007/s10072-019-3717-yDOI Listing
January 2019
1 Read

Evaluation of anxiety and depression scales and quality of LIFE in cervical dystonia patients on botulinum toxin therapy and their relatives.

Neurol Sci 2019 Jan 18. Epub 2019 Jan 18.

Medical Faculty, Department of Biostatistics, Uludag University, Bursa, Turkey.

Objective: In this study, quality of life and psychiatric comorbid disorders were investigated in patients with cervical dystonia and their spouses and we also investigated the effect of botulinum toxin (BTX) treatment on these parameters.

Material And Method: Thirty patients with cervical dystonia (CD) on BTX treatment and their spouses (n = 30) were included. Beck Depression Scale (BDS), State-Trait Anxiety Inventory I and II (STAI-I, STAI-II), Hospital Anxiety Scale (HAS), Hospital Depression Scale (HDS) for psychiatric comorbid disease assessment, Toronto Western Spasmodic Torticollis Scale (TWSTRS) for disease activity assessment, and Craniocervical Dystonia Questionnaire (CDQ-24), Cervical Dystonia Impact Profile (CDIP-58), and Short Form 36 (SF-36) questionnaires for quality of life assessment were used. Read More

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http://dx.doi.org/10.1007/s10072-019-3719-9DOI Listing
January 2019
1 Read

Exploring the feasibility of a mild and short 4-week combined upper limb and breathing exercise program as a possible home base program to decrease fatigue and improve quality of life in ambulatory and non-ambulatory multiple sclerosis individuals.

Neurol Sci 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurosurgery, Clinical Hospital Center, Rijeka, Croatia.

Purpose: To evaluate the feasibility of a combined upper limb and breathing exercise for a home-based program and to explore its effect on primary fatigue and quality of life in ambulatory and non-ambulatory individuals with multiple sclerosis (MS) in a short time.

Method: Nineteen individuals with MS were assigned into semi-controlled pre-post feasibility study based on Expanded Disability Status Scale (EDSS) status and divided into two groups: exercise (five ambulatory, five non-ambulatory; EDSS 1.0-8. Read More

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http://dx.doi.org/10.1007/s10072-019-3707-0DOI Listing
January 2019
6 Reads

Characteristics of obstructive sleep apnea in myasthenia gravis patients: a single center study.

Neurol Sci 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurology, Kyungpook National University Chilgok Hospital, Daegu, South Korea.

Background: Recent studies have shown a high prevalence of obstructive sleep apnea in myasthenia gravis compared to the normal population. The aim of this study was to elucidate clinical and polysomnographic differences between clinically stable Korean MG patients with and without OSA.

Methods: A total of 18 consecutively stable MG patients were included in this prospective study. Read More

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http://dx.doi.org/10.1007/s10072-019-3706-1DOI Listing
January 2019
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Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study.

Neurol Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Biostatistics, Selcuk University Faculty of Veterinary Medicine, Konya, Turkey.

Background: Migraine is a common neurovascular disease associated with vascular risks, especially in young adult females, but the mechanism underlying these associations remains unknown. This study evaluated the relationships between plasma endothelial dysfunction biomarkers and carotid intima-media thickness (IMT) in young adult females with migraine.

Methods: This case-control study included 148 female patients (age range: 18-50 years). Read More

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http://dx.doi.org/10.1007/s10072-019-3710-5DOI Listing
January 2019
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Normative values of the Rao's Brief Repeatable Battery in an Italian young adolescent population: the influence of age, gender, and education.

Neurol Sci 2019 Jan 15. Epub 2019 Jan 15.

Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Via Sergio Pansini, 5 - Building 17, Ground floor, Naples, Italy.

Aim: The Brief Repeatable Battery of Neuropsychological Tests (BRB) is frequently used to estimate cognitive function in adults with multiple sclerosis (MS), while it has been included in few studies on young MS, also because of the absence of normative values. We aim to evaluate the impact of age, gender, and education on BRB scores in a young adolescent population.

Methods: We administered the BRB to 76, 14-to-17-year-old, healthy subjects. Read More

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http://dx.doi.org/10.1007/s10072-019-3712-3DOI Listing
January 2019

Serum orexin-A levels are associated with disease progression and motor impairment in multiple sclerosis.

Neurol Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Neurology, Haydarpasa Numune Education and Research Hospital, Istanbul University, Istanbul, Turkey.

Objective: Diencephalon is frequently affected in multiple sclerosis (MS), and lesions of this region are associated with increased disability. Orexin-A and melatonin, two foremost mediators of diencephalon, modulate cognitive and motor functions through several pathways including the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) signaling pathway. In this pilot study, our aim was to investigate the prognostic value of these factors in progression of cognitive and physical disability. Read More

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http://dx.doi.org/10.1007/s10072-019-3708-zDOI Listing
January 2019
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Highlights of the Issue 2, 2019.

Authors:

Neurol Sci 2019 Feb;40(2):231-234

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http://dx.doi.org/10.1007/s10072-019-3715-0DOI Listing
February 2019

Inflammatory cytokines expression in Wilson's disease.

Neurol Sci 2019 Jan 14. Epub 2019 Jan 14.

Hospital Affiliated to Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, China.

Background: Wilson's disease (WD) is an autosomal recessive inherited disorder of copper (Cu) metabolism. Inflammation is a self-defensive reaction aimed at eliminating or neutralizing injurious stimuli, and restoring tissue integrity. Copper deposition may lead to inflammation in the organs and tissues of WD patients. Read More

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http://dx.doi.org/10.1007/s10072-018-3680-zDOI Listing
January 2019
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Methotrexate-induced toxic leukoencephalopathy: an uncommon stroke mimic.

Neurol Sci 2019 Jan 13. Epub 2019 Jan 13.

Department of Neurology and Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1007/s10072-019-3711-4DOI Listing
January 2019