4,216 results match your criteria Neurological Research[Journal]


Progesterone treatment in rats after severe global cerebral ischemia promotes hippocampal dentate gyrus neurogenesis and functional recovery.

Neurol Res 2019 Feb 14:1-8. Epub 2019 Feb 14.

a Unidad de Investigación Médica en Farmacología , CMN Siglo XXI, IMSS , México , México.

Objective: Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of newly generated hippocampal neurons, in relation to the performance of ischemic rats in a spatial learning task, was assessed in this study.

Methods: Adult male rats were subjected to a severe global cerebral ischemia episode (30 min) and treated with P4 or its vehicle at 15 min, 2, 6, 24, 48 and 72 h of reperfusion. Read More

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http://dx.doi.org/10.1080/01616412.2019.1576356DOI Listing
February 2019

Expression of telomere repeat binding factor 1 and TRF2 in Alzheimer's disease and correlation with clinical parameters.

Neurol Res 2019 Feb 14:1-6. Epub 2019 Feb 14.

b Department of Neurology , The Second Affiliated Hospital of Zhengzhou University , Zhengzhou , China.

Objective: The objective of this study was to investigate the expression of serum telomere repeat binding factor 1 (TRF1) and TRF2 in patients with Alzheimer's disease (AD) and their correlation with clinicopathological features.

Methods: Fifty AD subjects and 50 healthy controls were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the expression of TRF1 and TRF2 in the peripheral blood plasma. Read More

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http://dx.doi.org/10.1080/01616412.2019.1580456DOI Listing
February 2019

Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model.

Neurol Res 2019 Feb 13:1-10. Epub 2019 Feb 13.

e Department of Neurology, Shandong Provincial Qianfoshan Hospital , Shandong University , Jinan , China.

Background: Post-stroke depression (PSD) is one of the most prevalent emotional disorders after stroke and often results in poor outcomes. However, the underlying physiopathologic mechanism and effective treatment of PSD remain poorly elucidated.

Objective: To investigate whether paeoniflorin has antidepressant-like activity in a rat model of PSD. Read More

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http://dx.doi.org/10.1080/01616412.2019.1576361DOI Listing
February 2019

ECAS progression score: a web-based model to predict progression of extracranial carotid artery stenosis.

Neurol Res 2019 Feb 13:1-10. Epub 2019 Feb 13.

i Department of Cardiology , Kangji Hospital , Hebei , China.

Background And Purpose: To develop and validate a risk model (Extracranial Carotid Artery Stenosis progression score, ECAS-PS) and to predict risk of ECAS progression.

Methods: The ECAS-PS was developed based on the Renqiu Stroke Screening Study (RSSS), in which eligible participants were randomly divided into derivation (60%) and validation (40%) cohorts. ECAS at baseline and follow-up was diagosed by carotid duplex ultrasound according to the published criteria. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2019.1
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http://dx.doi.org/10.1080/01616412.2019.1576375DOI Listing
February 2019
2 Reads

COX-2 contributed to the remifentanil-induced hyperalgesia related to ephrinB/EphB signaling.

Neurol Res 2019 Feb 13:1-9. Epub 2019 Feb 13.

b Department of Anesthesiology , First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu Province , China.

Background and Objectives: Studying the underlying mechanisms of opiate-induced hyperalgesia is fundamental to understanding and treating pain. Our previous study has proved that ephrinB/EphB signaling contributes to opiate-induced hyperagesia, but the manner in which ephrinB/EphB signaling acts on spinal nociceptive information networks to produce hyperalgesia remains unclear. Other studies have suggested that ephrinB/EphB signaling, NMDA receptor and COX-2 act together to participate in the modulation of nociceptive information processes at the spinal level. Read More

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http://dx.doi.org/10.1080/01616412.2019.1580459DOI Listing
February 2019

Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.

Neurol Res 2019 Feb 11:1-9. Epub 2019 Feb 11.

b Institute of Materia Medica , Dali University , Dali , Yunnan , China.

Objective:  To investigate the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B (TrkB) protein in the hippocampus of model rats of comorbid epilepsy and depression.

Methods: A rat model of epilepsy was established using lithium chloride.pilocarpine. Read More

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http://dx.doi.org/10.1080/01616412.2019.1576358DOI Listing
February 2019

Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.

Neurol Res 2019 Feb 9:1-6. Epub 2019 Feb 9.

a Department of Neurosurgery, The National Key Clinic Specialty, Hainan General Hospital , Hainan Clinical Medicine Research Institution , Haikou , Hainan , P.R. China.

Objectives: We attempted to determine whether a functional polymorphism of TRPM6 (rs2274924) is associated with susceptibility to epilepsy following ischemic stroke, and to further explore the effect of this polymorphism on serum levels of Mg in post-stroke patients.

Methods: We carried out a case-control study on 378 post-stroke epilepsy patients and 420 controls (stroke patients without secondary epilepsy). We used DNA sequencing to determine the genotypes of the TRPM6 rs2274924 polymorphism, and used the ion selective electrode method to measure serum levels of Mg. Read More

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http://dx.doi.org/10.1080/01616412.2019.1568755DOI Listing
February 2019

Neuroprotective effects of Ellagic acid against acrylamide-induced neurotoxicity in rats.

Neurol Res 2019 Feb 8:1-10. Epub 2019 Feb 8.

h Razi Drug Research Center , Iran University of Medical Sciences , Tehran , Iran.

Acrylamide (ACR) is an environmental contaminant and a well-known neurotoxin. Ellagic acid (EA), a natural plant polyphenol, has shown a variety of beneficial effects. The present study was designed to explore whether EA could attenuate ACR-induced neurotoxicity in rats and to explore the underlying mechanisms. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2019.1
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http://dx.doi.org/10.1080/01616412.2019.1576319DOI Listing
February 2019
1 Read

Bax inhibitor-1 overexpression in prelimbic cortex protects rats against depression-like behavior induced by olfactory bulbectomy and reduces apoptotic and inflammatory signals.

Neurol Res 2019 Feb 8:1-9. Epub 2019 Feb 8.

a City College , Wuhan University of Science and Technology , Wuhan , China.

Background And Purpose: Depression is a mental disorder characterized by a pervasive low mood and loss of pleasure or interest in usual activities, and often results in the impairment of learning and memory. Bax inhibitor-1 (BI-1) has been reported to be involved in the pathological mechanisms for neurodegenerative disorders including depression. Here, we aimed to investigate the role of BI-1 in regulating depression-like behavior induced by olfactory bulbectomy (OB) in rats and the possible mechanism. Read More

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http://dx.doi.org/10.1080/01616412.2019.1565649DOI Listing
February 2019
1 Read

Dynamic thiol-disulphide homeostasis in patients with Guillain-Barre Syndrome.

Neurol Res 2019 Feb 7:1-6. Epub 2019 Feb 7.

d Faculty of Medicine, Department of Biochemistry , Ankara Yildirim Beyazit University , Ankara , Turkey.

Objective: The aim of this study was to evaluate dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in patients with Guillain-Barre syndrome (GBS).

Methods: A total of 130 participants were included in this study, 70 of whom were diagnosed with GBS. Total thiol (-SH+-S-S-) and native thiol (-SH) levels in serum were measured in all patients and healthy individuals. Read More

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http://dx.doi.org/10.1080/01616412.2019.1573955DOI Listing
February 2019
1 Read

Effect of folic acid supplementation on nerve conduction velocity in diabetic polyneuropathy patients.

Neurol Res 2019 Feb 7:1-5. Epub 2019 Feb 7.

e Department of Community Nutrition, School of Nutrition and Food Science , Isfahan University of Medical Sciences , Isfahan , Iran.

Objectives: In diabetic polyneuropathy (DPN) patients, the effect of folic acid and homocysteine has been related to components of nerve conduction velocity (NCV). The objective of this study was to determine the effect of folic acid supplementation on NCV in DPN patients.

Methods: Patients were randomized to receive either 1 mg of folic acid (n = 40) or placebo (n = 40) for 16 weeks. Read More

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http://dx.doi.org/10.1080/01616412.2019.1565180DOI Listing
February 2019
2 Reads
1.449 Impact Factor

Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.

Neurol Res 2019 Feb 1:1-14. Epub 2019 Feb 1.

a Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Frederiksberg , Denmark.

Objective: Ischaemic brain lesions and brain abscesses are frequent in both human and animal cases of septic embolic stroke. However, existing models of brain infection do not reflect central aspects of septic embolic stroke. Our aim was to compare septic and non-septic embolic stroke in order to identify gene expressions, inflammatory mediators and brain damage in a rat model. Read More

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http://dx.doi.org/10.1080/01616412.2019.1573455DOI Listing
February 2019

Portable fibrobronchoscopic treatment for non-severe ischemic stroke-associated pneumonia patients with dysphagia: a pilot study.

Neurol Res 2019 Jan 18:1-7. Epub 2019 Jan 18.

e Department of Neurology, Huai'an First People's Hospital , The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University , Huai'an , Jiangsu , China.

Objective: To investigate the efficacy and safety of portable fibrobronchoscopy on the non-severe ischemic stroke-associated pneumonia (SAP) patients with dysphagia.

Methods: A total of 86 non-severe ischemic SAP patients with dysphagia were randomly and equally divided into the treatment group and control group. The control group was given routine sputum suction, anti-infection drugs, and sputum-reducing drugs. Read More

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http://dx.doi.org/10.1080/01616412.2018.1548723DOI Listing
January 2019

COMT Val158Met polymorphism and Parkinson's disease risk: a pooled analysis in different populations.

Neurol Res 2019 Jan 15:1-7. Epub 2019 Jan 15.

a Department of Neurology , Ba-nan people's Hospital , Chongqing , China.

Objective: Many studies have analyzed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and Parkinson's disease (PD), which yield inconsistent results. This meta-analysis was designed to determine the possible association between the COMT Val158Met polymorphism and the risk of PD in different populations.

Methods: The PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure and Chinese Biology Medicine databases were used for literature searching up to May 2018. Read More

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http://dx.doi.org/10.1080/01616412.2018.1564183DOI Listing
January 2019
3 Reads

The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Neurol Res 2019 Jan 13:1-13. Epub 2019 Jan 13.

b Institute of Anatomy , University of Leipzig , Leipzig , Germany.

Introduction: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load.

Methods: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months.

Results: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1564191DOI Listing
January 2019
4 Reads

Sericin silk protein in peripheral nervous repair associated with the physical exercise of swimming in Wistar rats.

Neurol Res 2019 Jan 13:1-9. Epub 2019 Jan 13.

a Bioscience and Health Program , State University of the West of Paraná , Cascavel , Brazil.

Objective: To verify the action of sericin associated to swim exercise with overload, on sciatic nerve repair in Wistar rats, after 22 days of nerve compression.

Methods: Forty animals been composed of five groups: control, injury, injury-sericin, injury-swimming and injury-sericin-swimming. During the lesion procedure, sericin, in hydrolyzed form, applied directly to the injury in the injury-sericin and injury-sericin-swimming groups. Read More

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http://dx.doi.org/10.1080/01616412.2018.1564187DOI Listing
January 2019

Small ruptured intracranial aneurysms: the risk of massive bleeding and rebleeding.

Neurol Res 2019 Jan 13:1-7. Epub 2019 Jan 13.

a Department of Neurosurgery , The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.

Objective: The risk of hemorrhagic events in small ruptured aneurysms remains unclear. Due to less arterial wall, small ruptured aneurysms may be correlated with massive bleeding and rebleeding. Therefore, it may contribute to treatment to evaluate the amount of bleeding and the risk of rebleeding in small ruptured aneurysms. Read More

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http://dx.doi.org/10.1080/01616412.2018.1563737DOI Listing
January 2019
1 Read

Serum levels of insulin-like growth factor-1 and brain-derived neurotrophic factor as potential recovery biomarkers in stroke.

Neurol Res 2019 Jan 8:1-10. Epub 2019 Jan 8.

a Recovery and Performance Laboratory, Faculty of Medicine , Memorial University , St. John's , Canada.

Objectives: Our objectives were: 1) to determine whether maximal aerobic exercise increased serum neurotrophins in chronic stroke and 2) to determine the factors that predict resting and exercise-dependent levels.

Methods: We investigated the potential predictors of resting and exercise-dependent serum insulin-like growth factor-1 and brain-derived neurotrophic factor among 35 chronic stroke patients. Predictors from three domains (demographic, disease burden, and cardiometabolic) were entered into 4 separate stepwise linear regression models with outcome variables: resting insulin-like growth factor, resting brain-derived neurotrophic factor, exercise-dependent change in insulin-like growth factor, and exercise-dependent change brain-derived neurotrophic factor. Read More

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http://dx.doi.org/10.1080/01616412.2018.1564451DOI Listing
January 2019
1 Read

A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm.

Neurol Res 2019 Jan 5:1-6. Epub 2019 Jan 5.

a Department of Neurosurgery , XinHua Hospital (The Cranial Nerve Disease Center of Shanghai), Shanghai JiaoTong University School of Medicine , Shanghai , China.

Background: It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic pain, we attempt to analyze the correlation between cytokines and these hyperactive cranial nerve disorders.

Method: The consecutive patients whose diagnosis were confirmed by microvascular decompression surgery as primary TN or HFS caused by vascular compression and healthy volunteers between March and May 2018 in XinHua Hospital Shanghai JiaoTong University School of Medicine were recruited. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1564188DOI Listing
January 2019
1 Read

Occipital petalia as a predictive imaging sign for transverse sinus dominance.

Neurol Res 2019 Jan 2:1-6. Epub 2019 Jan 2.

a Department of Neurology, Faculty of Medicine , Hacettepe University , Ankara , Turkey.

Objectives: Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the association between occipital petalia and TS hypoplasia on MRI studies. Read More

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http://dx.doi.org/10.1080/01616412.2018.1560643DOI Listing
January 2019

Magnesium promotes the viability and induces differentiation of neural stem cells both in vitro and in vivo.

Neurol Res 2018 Dec 30:1-8. Epub 2018 Dec 30.

e Department of Endodontics , Jinan Stomatological Hospital , Jinan , China.

Objective: Neural stem cells (NSCs) are multipotent stem cells that generating various neural cells, including neurons, astrocytes and oligodendrocytes. This showed that NSCs is an ideal candidate in the application of neural disease treatment. In the current study, we established a simple and efficient method to promote the viability and induce the differentiation of NSCs by stimulating with magnesium. Read More

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http://dx.doi.org/10.1080/01616412.2018.1544400DOI Listing
December 2018

Adsorptive properties of graphene oxide on vitamin B12 and their effect on the promotion of peripheral nerve regeneration.

Neurol Res 2018 Dec 25:1-7. Epub 2018 Dec 25.

a Department of anatomy, College of Basic Medical Science , China Medical University , Shenyang , China.

Objectives: To observe whether Graphene oxide (GO) can absorb vitamin B12 (VB12) and Decellularized scaffold - acellular nerve allograft (ANA) modified GO-VB12 promote the repair of ischiadic nervus defects in a rat model.

Methods: The adsorption of GO on vitamin and the optimum adsorption conditions were investigated by single factor experiment. The adsorption properties of the material were observed by scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) to determine the success of adsorption on VB12. Read More

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http://dx.doi.org/10.1080/01616412.2018.1557868DOI Listing
December 2018

Intracerebroventricular infusion of D-serine decreases nociceptive behaviors induced by electrical stimulation of the dura mater of rat.

Neurol Res 2018 Dec 25:1-4. Epub 2018 Dec 25.

a Department of neurology , The Chinese PLA general hospital , Beijing , China.

Objective And Method: D-serine acts as an obligatory ligand for the glycine sites of N-methyl-D-aspartate receptors. To investigate its effect on head-facial pain, nociceptive behaviors of rats induced by electrical stimulation of the dura mater were observed after cerebroventricular infusion of D-serine.

Results: Rats in the D-serine infusion group showed significantly fewer nociceptive behaviors, including grooming and head flicking, than rats in the saline infusion group and control rats. Read More

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http://dx.doi.org/10.1080/01616412.2018.1531200DOI Listing
December 2018

The effect of duloxetine on penicillin-induced epileptiform activity in rats.

Neurol Res 2018 Dec 24:1-8. Epub 2018 Dec 24.

b Department of Physiology, Faculty of Medicine , Tokat Gaziosmanpasa University , Tokat , Turkey.

Aim: Previous studies showed the existence of a relationship between epilepsy and depression. Duloxetine is a potent and selective inhibitor of serotonin and norepinephrine reuptake (SNRI) used in the treatment of the major depressive disorder. The aim of the present study was to investigate the effect of duloxetine on penicillin-induced epileptiform activity in an experimental rat model of acute partial epilepsy. Read More

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http://dx.doi.org/10.1080/01616412.2018.1560642DOI Listing
December 2018

Diffusion tensor tractography to visualize axonal outgrowth and regeneration in a 4-cm reverse autograft sciatic nerve rabbit injury model.

Neurol Res 2018 Dec 24:1-8. Epub 2018 Dec 24.

a Department of Plastic Surgery , Vanderbilt University Medical Center , Nashville , TN , USA.

Background: Diffusion tensor tractography (DTT) has recently been shown to accurately detect nerve injury and regeneration. This study assesses whether 7-tesla (7T) DTT imaging is a viable modality to observe axonal outgrowth in a 4 cm rabbit sciatic nerve injury model fixed by a reverse autograft (RA) surgical technique.

Methods: Transection injury of unilateral sciatic nerve (4 cm long) was performed in 25 rabbits and repaired using a RA surgical technique. Read More

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http://dx.doi.org/10.1080/01616412.2018.1554284DOI Listing
December 2018
1 Read

Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke.

Neurol Res 2018 Dec 21:1-9. Epub 2018 Dec 21.

a Biotech Research and Innovation Centre , University of Copenhagen , Copenhagen , Denmark.

Objective: In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatment.

Methods: Data from 10 patients already on statins at stroke onset (Pre-S group) was compared with data from both 29 patients starting statin treatment right after stroke onset (Post-S group) and with 8 healthy controls. Read More

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http://dx.doi.org/10.1080/01616412.2018.1558000DOI Listing
December 2018
1.449 Impact Factor

Assessment of pre and post-thymectomy myasthenia gravis.

Neurol Res 2018 Dec 21:1-7. Epub 2018 Dec 21.

a Department of Neuromicrobiology , National Institute of Mental Health and Neurosciences , Bangalore , India.

Objective: To evaluate transcervical and transsternal thymectomy benefits in large myasthenia gravis (MG) cohort.

Method: We retrospectively evaluated MG patients (n = 184) who had undergone thymectomy between 2004 and 2015 at National Institute of Mental Health and Neurosciences, Bangalore (India). Myasthenia gravis foundation of America guidelines were followed to assess clinical outcome. Read More

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http://dx.doi.org/10.1080/01616412.2018.1557433DOI Listing
December 2018
1 Read

Regenerative activity of Hericium erinaceus on axonal injury model using in vitro laser microdissection technique.

Neurol Res 2018 Dec 20:1-10. Epub 2018 Dec 20.

b Neuroscience Research Unit, School of Medicine , Van Yüzüncü Yıl University , Van , Turkey.

Objective: Peripheral nerve injury (PNI) is an important global health problem. Nerve Growth Factor (NGF) plays crucial role in the survival, growth, and maintenance of various neurons in the mammalian nervous system, human included. Hericium erinaceus (HE), an edible and medicinal mushroom, has been extensively studied for its neuroprotective properties. Read More

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http://dx.doi.org/10.1080/01616412.2018.1556494DOI Listing
December 2018

Hyperuricemia and prognosis of acute ischemic stroke in diabetic patients.

Neurol Res 2018 Dec 11:1-7. Epub 2018 Dec 11.

b Department of Neurology , the first Affiliated Hospital of Harbin Medical University , Harbin , China.

Objectives: The relationship between hyperuricemia (HUA) and prognosis of acute ischemic stroke (AIS) is unclear. This prospective cohort study aims to evaluate potential value of HUA as a prognostic factor for AIS independent of diabetic status.

Methods: A total of 1041 consecutive patients aged from 25 to 96 with AIS were included. Read More

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http://dx.doi.org/10.1080/01616412.2018.1553347DOI Listing
December 2018
3 Reads

Structural and cognitive correlates of fatigue in progressive multiple sclerosis.

Neurol Res 2019 Feb 4;41(2):168-176. Epub 2018 Dec 4.

a Danish Multiple Sclerosis Centre (DMSC), Department of Neurology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

Background: Fatigue in multiple sclerosis (MS) is a debilitating symptom and experienced by most patients. In recent studies investigating this phenomenon, the majority of patients had a relapsing-remitting disease course.

Methods: Patients with progressive MS participating in one of three treatment trials during a period from 2010 to 2014 were included. Read More

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http://dx.doi.org/10.1080/01616412.2018.1547813DOI Listing
February 2019
1 Read

Early microalbuminuria as a clinical marker for acute cerebral small vessel infarction.

Neurol Res 2019 Feb 26;41(2):151-155. Epub 2018 Nov 26.

a Department of Neurology , ShengJing Hospital of China Medical University , Shenyang , Liaoning , P.R. China.

Background: Previous studies have shown the potential interactions between cerebrovascular diseases and microalbuminuria. However, the relationship between urine microalbumin and acute lacunar infarction caused by cerebral small vessel disease (CSVD) remains unknown.

Methods: The clinical data of 148 patients with acute lacunar infarction admitted to the Department of Neurology, Shengjing Hospital of China Medical University between April 2016 and April 2017 were analyzed. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1545413DOI Listing
February 2019
12 Reads

Both thapsigargin- and tunicamycin-induced endoplasmic reticulum stress increases expression of Hrd1 in IRE1-dependent fashion.

Neurol Res 2019 Feb 26;41(2):177-188. Epub 2018 Nov 26.

a Jessenius Faculty of Medicine in Martin (JFM CU), Biomedical Center Martin JFM CU and Department of Medical Biochemistry JFM CU , Comenius University in Bratislava , Martin , Slovakia.

Objectives: We have investigated the impact of endoplasmic reticulum (ER) stress, which is often implicated in neurodegenerative diseases, on the expression of Hrd1, an E3 ubiquitin ligase that plays a central role in the process of ER-associated degradation (ERAD).

Methods: SH-SY5Y neuroblastoma cells, a frequently used model for studying neurotoxicity in dopaminergic neurons and the mechanisms of neurodegeneration associated with Parkinson's disease, and parental SK-N-SH cells were studied.

Results: We demonstrate that ER stress, induced by thapsigargin or tunicamycin, correlates with the increased expression of Hrd1 in both SH-SY5Y and SK-N-SH cells. Read More

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http://dx.doi.org/10.1080/01616412.2018.1547856DOI Listing
February 2019
3 Reads

Active caspase-3 upregulation is augmented in at-risk cerebellar Purkinje cells following inferior olive chemoablation in the shaker mutant rat: an immunofluorescence study.

Authors:
Nour S Erekat

Neurol Res 2018 Nov 21:1-8. Epub 2018 Nov 21.

a Department of Anatomy, Faculty of Medicine , Jordan University of Science and Technology (JUST) , Irbid , Jordan.

Objectives: Mechanisms underlying Purkinje cell (PC) death, which leads to many diseases in humans, are still poorly elucidated. Progressive PC degeneration occurs in shaker mutant rat due to an X-linked recessive mutation leading to gait ataxia and total-body tremors. Chemoablation of the inferior olive (IO) and olivocerebellar deafferentation temporally accelerated PC death from the natural 6-8 week time-course to 1-2 weeks in the shaker mutant rat. Read More

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http://dx.doi.org/10.1080/01616412.2018.1548792DOI Listing
November 2018
11 Reads

Factors related to excessive sleepiness in patients with Parkinson's disease.

Neurol Res 2018 Nov 21:1-7. Epub 2018 Nov 21.

c Department of Neuroscience, Faculty of Medicine of Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.

Introduction: Excessive sleepiness (ES) can affect up to 60% of Parkinson's disease (PD) patients, and it has a multifactorial etiology. It is related to the neurodegenerative processes affecting brain regions responsible for the sleep-wake cycle, the effects of drugs acting on the central nervous system, and the excessive sleep fragmentation of this population.

Objectives: To identify the factors associated with the presence of ES in patients with PD. Read More

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http://dx.doi.org/10.1080/01616412.2018.1548746DOI Listing
November 2018
14 Reads

Time-dependent effect of oligomeric amyloid-β (1-42)-induced hippocampal neurodegeneration in rat model of Alzheimer's disease.

Neurol Res 2019 Feb 19;41(2):139-150. Epub 2018 Nov 19.

a Molecular Gerontology Laboratory, Department of Biochemistry , School of Life Sciences, Bharathidasan University , Tiruchirappalli , India.

Objective: Alzheimer's disease (AD) is characterized with an abnormal deposition of insoluble amyloid-beta (Aβ) peptide plaques, tangles formation and synaptic dysfunction. These result in impaired functioning of neuronal circuits and alter the behavioral response owing to activation of neurotransmitter receptors. Recently, it has been implicated that Aβ influences N-methyl d-aspartate (NMDA) receptor activation in AD; however, the molecular mechanism underlying remains unclear. Read More

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http://dx.doi.org/10.1080/01616412.2018.1544745DOI Listing
February 2019
5 Reads

Forced FoxO1:SV expression suppressed glioma cell proliferation through G2/M cell cycle arrests and increased apoptosis.

Neurol Res 2019 Feb 20;41(2):189-198. Epub 2018 Nov 20.

a Department of Neurology, Department of Neurology , the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.

Objective: Forkhead box O1 (FoxO1) plays a crucial role in the development of many tumors. Cyclin D kinase (CDK) 1 could influence the nuclear export and activity of FoxO1 through phosphorylation of serine (S). However, the effects of S phosphorylation in the development of glioma remain unclear. Read More

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http://dx.doi.org/10.1080/01616412.2018.1548724DOI Listing
February 2019

A novel cognitive-behavioral stress management method for multiple sclerosis. A brief report of an observational study.

Neurol Res 2018 Nov 19:1-4. Epub 2018 Nov 19.

b Post Graduate Course, "Stress Management and Health Promotion", Faculty of Medicine , National Kapodistrian University of Athens , Athens , Greece.

Objectives: Psychological stress is an important risk factor for multiple sclerosis (MS) onset, relapse, neurological symptoms and psychosocial adjustment to the disease. Mounting evidence suggests that stress management could halt the disease progression and improve patients' wellbeing. The aim of this study was to investigate the effectiveness of a novel cognitive-behavioral stress management technique (called Pythagorean Self-Awareness Intervention - PSAI) routinely used in our clinics in patients with MS. Read More

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http://dx.doi.org/10.1080/01616412.2018.1548745DOI Listing
November 2018
5 Reads

Reversed ophthalmic artery flow following ischemic stroke: a possible predictor of outcomes following carotid artery stenting.

Neurol Res 2019 Feb 15;41(2):132-138. Epub 2018 Nov 15.

f Institute of Statistics and Big Data Research Center , National Chiao Tung University , Hsinchu , Taiwan.

Stroke is the leading cause of death worldwide and stenosis of the carotid artery accounts for more than half of all cases. Carotid duplex is an effective non-invasive ultrasound test which identifies stroke patients with moderate to severe carotid stenosis who are candidates for preventative intervention to reduce the risk of recurrence. In patients with moderate to severe carotid stenosis, reversed ophthalmic artery flow (ROAF) is often observed at the time of the carotid duplex scan. Read More

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http://dx.doi.org/10.1080/01616412.2018.1544744DOI Listing
February 2019
13 Reads

Serum leptin is associated with first-ever ischemic stroke, lesion size and stroke severity in a Chinese cohort.

Neurol Res 2019 Feb 15;41(2):125-131. Epub 2018 Nov 15.

a Department of Neurology , The First Affiliated Hospital of Kunming Medical University , Kunming , PR China.

Objective: Leptin may be associated with cardiovascular disease. We tested to determine whether leptin is a marker for first-ever acute ischemic stroke (AIS) in a nested case-referent study.

Methods: Consecutive patients with first-ever AIS from May 2017 to December 2017 were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1544399DOI Listing
February 2019
9 Reads

Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.

Neurol Res 2019 Feb 10;41(2):118-124. Epub 2018 Nov 10.

e Department of Molecular Biology and Genetics, Joint Graduate Program in Biochemistry , Middle East Technical University , Ankara , Turkey.

Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role in the antioxidant system. The single nucleotide polymorphisms (SNPs), C419A and A424G in GST omega genes can cause a decrease in enzyme activity. Read More

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http://dx.doi.org/10.1080/01616412.2018.1544385DOI Listing
February 2019
1 Read

Analysis of biochemical laboratory values to determine etiology and prognosis in patients with subarachnoid hemorrhage: a clinical study.

Neurol Res 2019 Feb 10;41(2):156-167. Epub 2018 Nov 10.

a Faculty of Medicine, Department of Neurosurgery , Kirikkale University , Kirikkale , Turkey.

Objectives: The aim of this study was to establish prognostic and predictive markers in patients with subarachnoid hemorrhage (SAH) using simple laboratory methods.

Methods: A retrospective examination was made of patients with SAH diagnosed secondary to isolated head trauma, isolated anterior communicating artery aneurysm rupture, and angiography-negative SAH. Age, gender, Glasgow Coma Scale (GCS) scores, and Fisher's grade scores, Glasgow Outcome Scale (GOS) scores, leukocyte count, neutrophil count, lymphocyte count, platelet count, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio results (PLR) were evaluated. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1545414DOI Listing
February 2019
10 Reads

Influence of mTOR signaling pathway on ketamine-induced injuries in the hippocampal neurons of rats.

Neurol Res 2019 Jan 29;41(1):77-86. Epub 2018 Oct 29.

a Department of Anesthesiology , Third Hospital of Hebei Medical University , Shijiazhuang , China.

Objective: To explore the influences of mammalian target of rapamycin (mTOR) signaling pathway on ketamine-induced apoptosis, oxidative stress and Ca concentration in the hippocampal neurons of rats.

Methods: The primary hippocampal neurons isolated from fetal Sprague Dawley rats were treated with ketamine (0, 50, 100 and 500 μM) for 4 days to observe its effect on mTOR signaling pathway and apoptosis of rat hippocampal neurons. Then, the hippocampal neurons were divided into C (Control), R (Rapamycin, an inhibitor of mTOR signaling pathway), K (Ketamine) and R + K (Rapamycin + Ketamine) groups to detect the apoptosis, reactive oxygen species (ROS) production, and Ca concentration via the terminal transferase uridyl nick end labelling (TUNEL) assay, dichloro-dihydro-fluorescein diacetate (DCFH-DA) method and Fluo-3 acetoxymethyl ester (Fluo-3AM) staining, respectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1531203DOI Listing
January 2019
22 Reads

MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson's disease and multiple system atrophy.

Neurol Res 2019 Feb 30;41(2):110-117. Epub 2018 Oct 30.

a Department of Radiology , Ege University Medical Faculty , Izmir , Turkey.

Objectives: To evaluate the magnetic resonance imaging (MRI)-derived parameters in differentiation of patients with progressive supranuclear palsy (PSP) from patients with Parkinson's disease (PD), multiple system atrophy (MSA), and control subjects was aimed.

Methods: Thirty-three patients [mean age, 65.21 ± 4. Read More

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http://dx.doi.org/10.1080/01616412.2018.1541115DOI Listing
February 2019
3 Reads

A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis.

Neurol Res 2018 Dec;40(12):1040-1047

b Neonatal Intensive Care Unit, Linyi Central Hospital , Linyi , P. R. China.

Objectives: Multiple sclerosis (MS) is a T-cell-mediated disease of the central nervous system that develops in individuals possessing a complex susceptibility trait. We explored relationship between gene polymorphisms in MS.

Methods: To identify the associations of CXCR5 and IL2RA gene polymorphisms with susceptibility to MS, we recruited 263 MS patients from the Han nationality and 138 from the Hui nationality as MS group and 284 healthy volunteers from the Han nationality and 156 from the Hui nationality as controls. Read More

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http://dx.doi.org/10.1080/01616412.2018.1517110DOI Listing
December 2018
7 Reads

Hereditary and idiopathic spastic paraparesis: preliminary findings of a single center experience.

Neurol Res 2018 Dec;40(12):1088-1093

b Department of Neurology , Chinese PLA General Hospital , Beijing , China.

Objectives: Hereditary spastic paraplegias (HSP) is a heterogeneous group of inherited neurologic disorders with diversified clinical manifestations. The purpose of this study was to summarize the clinical manifestations of HSP by analyzing the clinical data of 56 HSP patients.

Methods: A total of 56 HSP patients treated in our hospital from January 2014 to March 2016 were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1522412DOI Listing
December 2018
2 Reads

Seizure forecasting using single robust linear feature as correlation vector of seizure-like events in brain slices preparation in vitro.

Neurol Res 2019 Feb 17;41(2):99-109. Epub 2018 Oct 17.

c Institute of Neurophysiology Charite - Universitatmedizin , Berlin , Germany.

Objective: Epilepsy is a neurological disorder affecting 50 million individuals globally. Modern research has inspected the likelihood of forecasting epileptic seizures. Algorithmic investigations are giving promising results for seizure prediction. Read More

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http://dx.doi.org/10.1080/01616412.2018.1532481DOI Listing
February 2019
5 Reads

Rapamycin alleviates proinflammatory cytokines and nociceptive behavior induced by chemotherapeutic paclitaxel.

Neurol Res 2018 Oct 16:1-8. Epub 2018 Oct 16.

a Department of Pulmonary Medicine , The First Hospital (Eastern Division) of Jilin University , Changchun , China.

Background/aims: Paclitaxel is largely used as a chemotherapeutic agent for the treatment of several types of cancers. However, one of the significant limiting complications of paclitaxel is painful peripheral neuropathy during its therapy. The purposes of this study were to examine (1) the effects of blocking mammalian target of rapamycin (mTOR) on mechanical and thermal hypersensitivity evoked by paclitaxel; and (2) the underlying mechanisms responsible for the role of mTOR in regulating paclitaxel-induced neuropathic pain. Read More

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http://dx.doi.org/10.1080/01616412.2018.1531199DOI Listing
October 2018
2 Reads

Diabetes mellitus inhibits complete recanalization in patients with middle cerebral artery occlusion.

Neurol Res 2018 Oct 15:1-8. Epub 2018 Oct 15.

d Tokushima University Hospital, Tokushima University , Tokushima , Japan.

Methods: This was a retrospective cohort study. Data from 165 patients, with middle cerebral occlusion before t-PA therapy (from the YAMATO study databank), were retrospectively evaluated. Patients were classified into diabetic (D) or non-diabetic (ND) groups based on the history of diabetes mellitus (DM) or hemoglobin A1c levels of ≥ 6. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1531201DOI Listing
October 2018
9 Reads

D-dimer >2.785 μg/ml and multiple infarcts ≥3 vascular territories are two characteristics of identifying cancer-associated ischemic stroke patients.

Neurol Res 2018 Nov;40(11):948-954

a Department of Neurology , First Affiliated Hospital of Anhui Medical University , Hefei , China.

Background: The patterns and mechanisms underlying stroke in cancer patients differ from those of the conventional etiology. In this study, we further investigated the characteristics distinguishing cancer-associated ischemic stroke (CAIS) and the relationship of D-dimer value with CAIS.

Methods: Sixty-one acute ischemic stroke patients with cancer (cancer group) and 76 stroke patients without cancer (control group) were recruited. Read More

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http://dx.doi.org/10.1080/01616412.2018.1504179DOI Listing
November 2018
3 Reads

Effect of regular swimming exercise to duration-intensity on neurocognitive function in cerebral infarction rat model.

Neurol Res 2018 Oct 12:1-8. Epub 2018 Oct 12.

a Department of Physical & Rehabilitation Medicine , Chonnam National University Hospital & Medical School , Gwangju , Republic of Korea.

Objective: This study investigated the effect of regular swimming exercise according to the duration-intensity on neurocognitive function in a cerebral infarction rat model.

Methods: Forty male Sprague-Dawley 10-week-old rats, weighing 300 ± 50 g, were subjected to photothrombotic cerebral infarction. The remaining 36 rats were randomly divided into four groups (n = 9 per group: non-exercise (group A); swimming exercise of short duration-intensity (5 min/day, group B); swimming exercise of moderate duration-intensity (10 min/day, group C); and swimming exercise of long duration-intensity (20 min/day, group D). Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1524087DOI Listing
October 2018
1 Read