4,234 results match your criteria Neurological Research[Journal]


Dynamic expression of glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1 in the mouse spinal cord dorsal horn under pathological pain states.

Neurol Res 2019 Apr 19:1-11. Epub 2019 Apr 19.

a Department of Physiology, Laboratory of Pain Neurobiology, Ribeirão Preto School of Medicine , University of São Paulo , Ribeirão Preto , Brazil.

Objective: Animal models of chronic pain have demonstrated that glial cells are promising target for development of analgesic drugs. However, preclinical studies on glial response under chronic pain conditions vary depending on the cellular markers, the species used, the experimental design and model. Therefore, we investigate the expression profile of GFAP and Iba-1 during the behavioral manifestation of sensory disorder in inflammatory and neuropathic pain models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1603804DOI Listing

From big data to battling disease: notes from the frontiers of cerebrovascular science.

Neurol Res 2019 Apr 14:1-2. Epub 2019 Apr 14.

a Department of Neurosurgery , Wayne State University School of Medicine , Detroit , MI , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1603592DOI Listing

Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.

Neurol Res 2019 Apr 11:1-15. Epub 2019 Apr 11.

f Department of Medical Biochemistry , Faculty of Medicine, Mansoura University , Mansoura , Egypt.

Recent evidence has suggested that cadmium (Cd) ions-induced neurotoxicity is associated with increased oxidative stress and mitochondrial-dependent and endoplasmic reticulum (ER) stress-induced apoptosis. This study aimed to investigate if rutin hydrate (RH), a well-reported neuroprotective and an antioxidant flavonoid, can ameliorate cadmium chloride (CdCl2)-induced neurotoxicity by inhibiting the resultant ER stress. Rats were divided into 4 groups (n = 16/group) of control, control + RH (100 mg/kg), CdCl (5 mg/kg), and CdCl + RH. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01616412.2019.1
Publisher Site
http://dx.doi.org/10.1080/01616412.2019.1596206DOI Listing
April 2019
3 Reads

Low-dose ethanol ameliorates amnesia induced by a brief seizure model: the role of NMDA signaling.

Neurol Res 2019 Apr 9:1-9. Epub 2019 Apr 9.

a Physiology Research Center , Kashan University of Medical Sciences , Kashan , Iran.

Objective: The present study aimed to evaluate the ameliorative effect of low-dose ethanol (Eth) on amnesia induced by a brief seizure model and the role of N-methyl D-aspartate (NMDA) signaling in this event.

Materials And Methods: Four groups of rats (total number = 36; n = 9, each group) were used: control, Eth (0.5 g/kg/i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1602322DOI Listing

Microalbuminuria in patients with acute ischemic stroke.

Neurol Res 2019 Apr 1:1-6. Epub 2019 Apr 1.

b Department of Neurology , Renmin Hospital of Wuhan University , Wuhan , China.

Objective: Microalbuminuria could be detected in patients with acute stroke. However, the association between microalbuminuria and the severity of ischemic stroke has not been systematically investigated. This study aimed to systematically explore the prevalence of microalbuminuria in ischemic stroke patients, and the association of microalbuminuria with the severity of ischemic stroke, as well as the prognostic value of microalbuminuria in cerebral infarction patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1576320DOI Listing
April 2019
5 Reads
1.449 Impact Factor

Activation and blockade of serotonin receptors in the lateral habenula improve working memory in unilateral 6-hydroxydopamine-lesioned Parkinson's rats.

Neurol Res 2019 Mar 30:1-9. Epub 2019 Mar 30.

a Department of Physiology and Pathophysiology, School of Basic Medical Sciences , Xi'an Jiaotong University Health Science Center , Xi'an , China.

Objective: The aim of the present study was to investigate the effects and mechanism of 6-hydroxydopamine (6-OHDA) lesions and serotonin  (5-HT) receptors in the lateral habenula (LHb) on Parkinson's disease (PD) related working memory.

Methods: The working memory was measured by the T-maze rewarded alternation test in sham rats and rats with unilateral 6-OHDA lesions of substantia nigra pars compacta (SNc). The concentrations of dopamine (DA), noradrenaline (NA) and 5-HT in the related brain regions were measured by neurochemistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1596055DOI Listing
March 2019
1 Read
1.449 Impact Factor

Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis.

Neurol Res 2019 Mar;41(3):199-203

a Department of Neurology , Beijing Ditan Hospital, Capital Medical University , Beijing , China.

Objective To investigate the diagnostic value of electroencephalogram (EEG) complexity in patients with neurosyphilis by comparing the changes of electroencephalogram Lempel-Ziv complexity (EEG-LZC) before and after anti-syphilis treatment. Methods The EEG complexity of neurosyphilis patients diagnosed in our hospital from July in 2015 to June in 2017 was analyzed and compared with other diagnostic results such as serology examination and cerebrospinal fluid examination. Results A total of 27 patients were diagnosed, including 19 males and 8 females, of which 6 were mesenchymal(cerebrospinal membrane and meningeal vascular), 16 were parenchymal(paralytic dementia, spinal cord tuberculosis and optic neuropathy), and 5 were asymptomatic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1520438DOI Listing
March 2019
1 Read

Preparation and characterization of a novel acellular swim bladder as dura mater substitute.

Neurol Res 2019 Mar 13;41(3):242-249. Epub 2019 Jan 13.

a Qingdao Chunghao Tissue Engineering Co,LTD , Qingdao , Shandong Province , China.

Objectives: This paper aimed to develop a novel dura mater substitute made from swim bladders.

Methods: The swim bladders were decellularized by diverse methods. The physical structure, residual DNA amount, mechanical properties and hemolysis rate were tested. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1550139DOI Listing

The effect of harmaline on seizures induced by amygdala kindling in rats.

Neurol Res 2019 Mar 19:1-8. Epub 2019 Mar 19.

c Cellular and Molecular Research Center , Sabzevar University of Medical Sciences , Sabzevar , Iran.

Objective: Harmaline and other beta-carbolines act as an inverse agonist for GABA-A receptors and cause central nervous system stimulation and anxiety; thus, it may act hypothetically as a potential seizure augmenter. To examine the hypothesis, the effect of harmaline during the seizures induced by amygdala kindling is investigated here.

Methods: Seven groups of male rats were kindled by daily electrical stimulation of the amygdala. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1580460DOI Listing
March 2019
1 Read

Characteristics of patients with vitamin B12-responsive neuropathy: a case series with systematic repeated electrophysiological assessment.

Neurol Res 2019 Mar 19:1-8. Epub 2019 Mar 19.

e Department of Neurology , Groupe Hospitalier Pellegrin , Bordeaux , France.

Background: Vitamin B12 (B12) has a fundamental role in both central and peripheral nervous system function at all ages. Neurologic manifestations may be the earliest and often the only manifestation of B12 deficiency. Mostly because of the poor sensitivity of methods of determination for B12 levels, peripheral neuropathy remains a classical but underdiagnosed complication of B12 deficiency. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01616412.2019.1
Publisher Site
http://dx.doi.org/10.1080/01616412.2019.1588490DOI Listing
March 2019
7 Reads

The effect of lithium chloride on BDNF, NT3, and their receptor mRNA levels in the spinal contusion rat models.

Neurol Res 2019 Mar 17:1-7. Epub 2019 Mar 17.

a Department of Anatomy , School of Medicine, Zanjan University of Medical Sciences (ZUMS) , Zanjan , Iran.

Objective: Nowadays, there seems to be no decisive way for treatment of spinal cord injury (SCI).Extensive cell death (apoptosis and necrosis) occurring in SCI can cause considerable progressive sensorimotor disabilities. Preventing cell death by improving endogenous regenerative capability could an effective strategy for the treatment of SCI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1588507DOI Listing

Family history of stroke and death or vascular events within one year after ischemic stroke.

Neurol Res 2019 May 4;41(5):466-472. Epub 2019 Mar 4.

b Department of Epidemiology , Tulane University School of Public Health and Tropical Medicine , New Orleans , LA , USA.

Background And Aims: The association between family history of stroke and clinical outcomes after ischemic stroke remains unclear.

Methods: A total of 3878 acute ischemic stroke patients from CATIS were included. The participants with ischemic stroke were divided into groups according to types of family history of stroke, stroke onset age and stroke subtypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1577342DOI Listing
May 2019
1 Read
1.449 Impact Factor

Low-dose rt-PA may not decrease the incidence of symptomatic intracranial haemorrhage in patients with high risk of symptomatic intracranial haemorrhage.

Neurol Res 2019 May 1;41(5):473-479. Epub 2019 Mar 1.

b Center of Stroke, Beijing Tiantan Hospital , Capital Medical University , Beijing , China.

Background: Recombinant tissue plasminogen activator (rt-PA) has been used as the standard treatment for acute ischemic stroke (AIS). The following study investigates whether low-dose rt-PA can decrease the incidence of symptomatic intracranial haemorrhage (sICH) in AIS patients with high-risk sICH compared to standard-dose rt-PA.

Materials And Methods: Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) studies were assessed to explore risk factors for sICH after intravenous thrombolysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1580454DOI Listing
May 2019
2 Reads
1.449 Impact Factor

Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion.

Neurol Res 2019 Mar 1:1-10. Epub 2019 Mar 1.

d Pharmacology Department, School of pharmacy , Anadolu University , Eskisehir , Turkey.

Objectives: Neuropathic pain reduces the life qualities of patients with Diabetes mellitus. Clinical guidelines recommend relief in diabetic neuropathic pain through the use of some antidepressants, anticonvulsants, opioids as well as capsaicin cream or lidocaine patches. However, since the majority of patients do not or partially respond to current treatments, there is a growing necessity for new drugs increasing the pain relief in patients with diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1580462DOI Listing
March 2019
2 Reads

Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.

Neurol Res 2019 Mar 1:1-9. Epub 2019 Mar 1.

a Course of Physical Therapy, School of Health Sciences, Faculty of Medicine , Kagoshima University , Kagoshima , Japan.

Objective: Preconditioning exercise can exert neuroprotective effects after stroke; however, the effects of exercise intensity, frequency, duration are unknown. We investigated the neuroprotective effect of different frequency preconditioning exercise on neuronal apoptosis after cerebral ischemia in rats.

Methods: Rats were divided into the following five groups: 5 times a week of exercise (5/w-Ex) group, 3 times a week of exercise (3/w-Ex) group, once a week of exercise (1/w-Ex) group, no exercise (No-Ex) group, and intact control (control) group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1580458DOI Listing
March 2019
7 Reads

JM-20 protects memory acquisition and consolidation on scopolamine model of cognitive impairment.

Neurol Res 2019 May 1;41(5):385-398. Epub 2019 Mar 1.

a Laboratorio de Neurofarmacología Molecular , Centro de Investigación y Desarrollo de Medicamentos , La Habana , Cuba.

Objective: JM-20, a novel hybrid synthetic molecule, has been reported to have antioxidant, mitoprotective, anti-excitotoxic, anti-apoptotic and anti-inflammatory properties. However, the neuroprotective effect of JM-20 against memory impairment in preclinical AD-like models has not been analyzed. The aim of this study was to evaluate the potential neuroprotection of JM-20 that preserves essential memory process from cholinergic dysfunction and other molecular damages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1573285DOI Listing
May 2019
2 Reads
1.449 Impact Factor

Forward deployed coil embolization with multiple overlapping stents for ruptured blood blister-like aneurysms: technical considerations and outcomes.

Neurol Res 2019 Mar 1:1-7. Epub 2019 Mar 1.

d Department of Neurosurgery , Ajou University Hospital, Ajou University School of Medicine , Suwon , Republic of Korea.

Background: Coil embolization with multiple overlapping stents was performed as an alternative treatment option for blood blister-like aneurysms (BBAs). However, coil placement into the BBAs has the inherent risks of rupture and regrowth. We describe a safe dense coil packing technique into and just proximal of BBAs using a semi-jailing technique for the treatment of BBAs of the internal carotid artery (ICA) and report the long-term clinical outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1584424DOI Listing

Microarray gene expression profiling and bioinformatics analysis reveal key differentially expressed genes in clival and sacral chordoma cell lines.

Neurol Res 2019 Mar 1:1-8. Epub 2019 Mar 1.

a Department of Neurosurgery , West China Hospital, Sichuan University , Chengdu , Sichuan , China.

Objective: Chordoma is a rare tumor with a certain rate of distant metastasis. Skull base and sacrum are the two most common origin sites. This study tends to identify key differentially expressed genes (DEGs) between classical clival and sacral chordomas, provide new targets for future treatment options of chordomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1582182DOI Listing

Exposure to female estrous is beneficial for male mice against transient ischemic stroke.

Neurol Res 2019 Feb 27:1-8. Epub 2019 Feb 27.

a School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.

Objective: Exposure to female estrous, a natural rewarding experience, alleviates anxiety and depression, and the contribution of this behavior to stroke outcome is unknown. The aim of this study was to evaluate whether exposure to female estrous is beneficial to recovery following transient ischemic stroke in male mice.

Methods: Cerebral ischemia was induced in male ICR mice with thread occlusion of the middle cerebral artery (MCAO) for 30 min followed by reperfusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1580461DOI Listing
February 2019
3 Reads

Cilostazol may improve cognition better than clopidogrel in non-surgical adult patients with ischemic moyamoya disease: subanalysis of a prospective cohort.

Neurol Res 2019 May 18;41(5):480-487. Epub 2019 Feb 18.

a Department of Neurosurgery , School of Medicine, Iwate Medical University , Morioka , Japan.

Objective: Adult patients with ischemic moyamoya disease (MMD) who receive treatment with antiplatelet drugs reportedly show improvements in neuropsychological test scores after around 2 years. The purpose of the present study subanalyzing the same patient cohort used in a previous study was to determine which antiplatelet drug, clopidogrel or cilostazol, results in better improvement of cognitive function among non-surgical adult patients showing ischemic MMD without severe hemodynamic compromise.

Methods: Sixty-six patients without cerebral misery perfusion on O gas positron emission tomography were treated with pharmacotherapy alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1580455DOI Listing
May 2019
1 Read

Progesterone treatment in rats after severe global cerebral ischemia promotes hippocampal dentate gyrus neurogenesis and functional recovery.

Neurol Res 2019 May 14;41(5):429-436. Epub 2019 Feb 14.

a Unidad de Investigación Médica en Farmacología , CMN Siglo XXI, IMSS , México , México.

Objective: Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of newly generated hippocampal neurons, in relation to the performance of ischemic rats in a spatial learning task, was assessed in this study.

Methods: Adult male rats were subjected to a severe global cerebral ischemia episode (30 min) and treated with P4 or its vehicle at 15 min, 2, 6, 24, 48 and 72 h of reperfusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1576356DOI Listing

Expression of telomere repeat binding factor 1 and TRF2 in Alzheimer's disease and correlation with clinical parameters.

Neurol Res 2019 Feb 14:1-6. Epub 2019 Feb 14.

b Department of Neurology , The Second Affiliated Hospital of Zhengzhou University , Zhengzhou , China.

Objective: The objective of this study was to investigate the expression of serum telomere repeat binding factor 1 (TRF1) and TRF2 in patients with Alzheimer's disease (AD) and their correlation with clinicopathological features.

Methods: Fifty AD subjects and 50 healthy controls were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the expression of TRF1 and TRF2 in the peripheral blood plasma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1580456DOI Listing
February 2019
1 Read

Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model.

Neurol Res 2019 May 13;41(5):446-455. Epub 2019 Feb 13.

e Department of Neurology, Shandong Provincial Qianfoshan Hospital , Shandong University , Jinan , China.

Background: Post-stroke depression (PSD) is one of the most prevalent emotional disorders after stroke and often results in poor outcomes. However, the underlying physiopathologic mechanism and effective treatment of PSD remain poorly elucidated.

Objective: To investigate whether paeoniflorin has antidepressant-like activity in a rat model of PSD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1576361DOI Listing
May 2019
3 Reads

ECAS progression score: a web-based model to predict progression of extracranial carotid artery stenosis.

Neurol Res 2019 May 13;41(5):456-465. Epub 2019 Feb 13.

i Department of Cardiology , Kangji Hospital , Hebei , China.

Background And Purpose: To develop and validate a risk model (Extracranial Carotid Artery Stenosis progression score, ECAS-PS) and to predict risk of ECAS progression.

Methods: The ECAS-PS was developed based on the Renqiu Stroke Screening Study (RSSS), in which eligible participants were randomly divided into derivation (60%) and validation (40%) cohorts. ECAS at baseline and follow-up was diagosed by carotid duplex ultrasound according to the published criteria. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01616412.2019.1
Publisher Site
http://dx.doi.org/10.1080/01616412.2019.1576375DOI Listing
May 2019
21 Reads

COX-2 contributed to the remifentanil-induced hyperalgesia related to ephrinB/EphB signaling.

Neurol Res 2019 Feb 13:1-9. Epub 2019 Feb 13.

b Department of Anesthesiology , First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu Province , China.

Background and Objectives: Studying the underlying mechanisms of opiate-induced hyperalgesia is fundamental to understanding and treating pain. Our previous study has proved that ephrinB/EphB signaling contributes to opiate-induced hyperagesia, but the manner in which ephrinB/EphB signaling acts on spinal nociceptive information networks to produce hyperalgesia remains unclear. Other studies have suggested that ephrinB/EphB signaling, NMDA receptor and COX-2 act together to participate in the modulation of nociceptive information processes at the spinal level. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1580459DOI Listing
February 2019
2 Reads

Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.

Neurol Res 2019 May 11;41(5):437-445. Epub 2019 Feb 11.

b Institute of Materia Medica , Dali University , Dali , Yunnan , China.

Objective:  To investigate the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B (TrkB) protein in the hippocampus of model rats of comorbid epilepsy and depression.

Methods: A rat model of epilepsy was established using lithium chloride.pilocarpine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1576358DOI Listing
May 2019
2 Reads
1.449 Impact Factor

Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.

Neurol Res 2019 Apr 9;41(4):378-383. Epub 2019 Feb 9.

a Department of Neurosurgery, The National Key Clinic Specialty, Hainan General Hospital , Hainan Clinical Medicine Research Institution , Haikou , Hainan , P.R. China.

Objectives: We attempted to determine whether a functional polymorphism of TRPM6 (rs2274924) is associated with susceptibility to epilepsy following ischemic stroke, and to further explore the effect of this polymorphism on serum levels of Mg in post-stroke patients.

Methods: We carried out a case-control study on 378 post-stroke epilepsy patients and 420 controls (stroke patients without secondary epilepsy). We used DNA sequencing to determine the genotypes of the TRPM6 rs2274924 polymorphism, and used the ion selective electrode method to measure serum levels of Mg. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1568755DOI Listing

Neuroprotective effects of Ellagic acid against acrylamide-induced neurotoxicity in rats.

Neurol Res 2019 May 8;41(5):419-428. Epub 2019 Feb 8.

h Razi Drug Research Center , Iran University of Medical Sciences , Tehran , Iran.

Acrylamide (ACR) is an environmental contaminant and a well-known neurotoxin. Ellagic acid (EA), a natural plant polyphenol, has shown a variety of beneficial effects. The present study was designed to explore whether EA could attenuate ACR-induced neurotoxicity in rats and to explore the underlying mechanisms. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01616412.2019.1
Publisher Site
http://dx.doi.org/10.1080/01616412.2019.1576319DOI Listing
May 2019
8 Reads
1.449 Impact Factor

Bax inhibitor-1 overexpression in prelimbic cortex protects rats against depression-like behavior induced by olfactory bulbectomy and reduces apoptotic and inflammatory signals.

Neurol Res 2019 Apr 8;41(4):369-377. Epub 2019 Feb 8.

a City College , Wuhan University of Science and Technology , Wuhan , China.

Background And Purpose: Depression is a mental disorder characterized by a pervasive low mood and loss of pleasure or interest in usual activities, and often results in the impairment of learning and memory. Bax inhibitor-1 (BI-1) has been reported to be involved in the pathological mechanisms for neurodegenerative disorders including depression. Here, we aimed to investigate the role of BI-1 in regulating depression-like behavior induced by olfactory bulbectomy (OB) in rats and the possible mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1565649DOI Listing
April 2019
9 Reads

Dynamic thiol-disulphide homeostasis in patients with Guillain-Barre Syndrome.

Neurol Res 2019 May 7;41(5):413-418. Epub 2019 Feb 7.

d Faculty of Medicine, Department of Biochemistry , Ankara Yildirim Beyazit University , Ankara , Turkey.

Objective: The aim of this study was to evaluate dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in patients with Guillain-Barre syndrome (GBS).

Methods: A total of 130 participants were included in this study, 70 of whom were diagnosed with GBS. Total thiol (-SH+-S-S-) and native thiol (-SH) levels in serum were measured in all patients and healthy individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1573955DOI Listing
May 2019
1 Read
1.449 Impact Factor

Effect of folic acid supplementation on nerve conduction velocity in diabetic polyneuropathy patients.

Neurol Res 2019 Apr 7;41(4):364-368. Epub 2019 Feb 7.

a Food Security Research Center , Isfahan University of Medical Sciences , Isfahan , Iran.

Objectives: In diabetic polyneuropathy (DPN) patients, the effect of folic acid and homocysteine has been related to components of nerve conduction velocity (NCV). The objective of this study was to determine the effect of folic acid supplementation on NCV in DPN patients.

Methods: Patients were randomized to receive either 1 mg of folic acid (n = 40) or placebo (n = 40) for 16 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1565180DOI Listing
April 2019
2 Reads
1.449 Impact Factor

Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.

Neurol Res 2019 May 1;41(5):399-412. Epub 2019 Feb 1.

a Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Frederiksberg , Denmark.

Objective: Ischaemic brain lesions and brain abscesses are frequent in both human and animal cases of septic embolic stroke. However, existing models of brain infection do not reflect central aspects of septic embolic stroke. Our aim was to compare septic and non-septic embolic stroke in order to identify gene expressions, inflammatory mediators and brain damage in a rat model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2019.1573455DOI Listing
May 2019
1 Read
1.449 Impact Factor

Portable fibrobronchoscopic treatment for non-severe ischemic stroke-associated pneumonia patients with dysphagia: a pilot study.

Neurol Res 2019 Mar 18;41(3):216-222. Epub 2019 Jan 18.

e Department of Neurology, Huai'an First People's Hospital , The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University , Huai'an , Jiangsu , China.

Objective: To investigate the efficacy and safety of portable fibrobronchoscopy on the non-severe ischemic stroke-associated pneumonia (SAP) patients with dysphagia.

Methods: A total of 86 non-severe ischemic SAP patients with dysphagia were randomly and equally divided into the treatment group and control group. The control group was given routine sputum suction, anti-infection drugs, and sputum-reducing drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1548723DOI Listing
March 2019
1 Read

COMT Val158Met polymorphism and Parkinson's disease risk: a pooled analysis in different populations.

Neurol Res 2019 Apr 15;41(4):319-325. Epub 2019 Jan 15.

a Department of Neurology , Ba-nan people's Hospital , Chongqing , China.

Objective: Many studies have analyzed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and Parkinson's disease (PD), which yield inconsistent results. This meta-analysis was designed to determine the possible association between the COMT Val158Met polymorphism and the risk of PD in different populations.

Methods: The PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure and Chinese Biology Medicine databases were used for literature searching up to May 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1564183DOI Listing
April 2019
9 Reads

The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Neurol Res 2019 Apr 13;41(4):341-353. Epub 2019 Jan 13.

b Institute of Anatomy , University of Leipzig , Leipzig , Germany.

Introduction: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load.

Methods: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months.

Results: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
Publisher Site
http://dx.doi.org/10.1080/01616412.2018.1564191DOI Listing
April 2019
9 Reads

Sericin silk protein in peripheral nervous repair associated with the physical exercise of swimming in Wistar rats.

Neurol Res 2019 Apr 13;41(4):326-334. Epub 2019 Jan 13.

a Bioscience and Health Program , State University of the West of Paraná , Cascavel , Brazil.

Objective: To verify the action of sericin associated to swim exercise with overload, on sciatic nerve repair in Wistar rats, after 22 days of nerve compression.

Methods: Forty animals been composed of five groups: control, injury, injury-sericin, injury-swimming and injury-sericin-swimming. During the lesion procedure, sericin, in hydrolyzed form, applied directly to the injury in the injury-sericin and injury-sericin-swimming groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1564187DOI Listing
April 2019
2 Reads

Small ruptured intracranial aneurysms: the risk of massive bleeding and rebleeding.

Neurol Res 2019 Apr 13;41(4):312-318. Epub 2019 Jan 13.

a Department of Neurosurgery , The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.

Objective: The risk of hemorrhagic events in small ruptured aneurysms remains unclear. Due to less arterial wall, small ruptured aneurysms may be correlated with massive bleeding and rebleeding. Therefore, it may contribute to treatment to evaluate the amount of bleeding and the risk of rebleeding in small ruptured aneurysms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1563737DOI Listing
April 2019
1 Read

Serum levels of insulin-like growth factor-1 and brain-derived neurotrophic factor as potential recovery biomarkers in stroke.

Neurol Res 2019 Apr 8;41(4):354-363. Epub 2019 Jan 8.

a Recovery and Performance Laboratory, Faculty of Medicine , Memorial University , St. John's , Canada.

Objectives: Our objectives were: 1) to determine whether maximal aerobic exercise increased serum neurotrophins in chronic stroke and 2) to determine the factors that predict resting and exercise-dependent levels.

Methods: We investigated the potential predictors of resting and exercise-dependent serum insulin-like growth factor-1 and brain-derived neurotrophic factor among 35 chronic stroke patients. Predictors from three domains (demographic, disease burden, and cardiometabolic) were entered into 4 separate stepwise linear regression models with outcome variables: resting insulin-like growth factor, resting brain-derived neurotrophic factor, exercise-dependent change in insulin-like growth factor, and exercise-dependent change brain-derived neurotrophic factor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1564451DOI Listing
April 2019
1 Read

A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm.

Neurol Res 2019 Apr 5;41(4):335-340. Epub 2019 Jan 5.

a Department of Neurosurgery , XinHua Hospital (The Cranial Nerve Disease Center of Shanghai), Shanghai JiaoTong University School of Medicine , Shanghai , China.

Background: It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic pain, we attempt to analyze the correlation between cytokines and these hyperactive cranial nerve disorders.

Method: The consecutive patients whose diagnosis were confirmed by microvascular decompression surgery as primary TN or HFS caused by vascular compression and healthy volunteers between March and May 2018 in XinHua Hospital Shanghai JiaoTong University School of Medicine were recruited. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
Publisher Site
http://dx.doi.org/10.1080/01616412.2018.1564188DOI Listing
April 2019
2 Reads

Occipital petalia as a predictive imaging sign for transverse sinus dominance.

Neurol Res 2019 Apr 2;41(4):306-311. Epub 2019 Jan 2.

a Department of Neurology, Faculty of Medicine , Hacettepe University , Ankara , Turkey.

Objectives: Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the association between occipital petalia and TS hypoplasia on MRI studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1560643DOI Listing

Magnesium promotes the viability and induces differentiation of neural stem cells both in vitro and in vivo.

Neurol Res 2019 Mar 30;41(3):208-215. Epub 2018 Dec 30.

e Department of Endodontics , Jinan Stomatological Hospital , Jinan , China.

Objective: Neural stem cells (NSCs) are multipotent stem cells that generating various neural cells, including neurons, astrocytes and oligodendrocytes. This showed that NSCs is an ideal candidate in the application of neural disease treatment. In the current study, we established a simple and efficient method to promote the viability and induce the differentiation of NSCs by stimulating with magnesium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1544400DOI Listing

Adsorptive properties of graphene oxide on vitamin B12 and their effect on the promotion of peripheral nerve regeneration.

Neurol Res 2019 Mar 25;41(3):282-288. Epub 2018 Dec 25.

a Department of anatomy, College of Basic Medical Science , China Medical University , Shenyang , China.

Objectives: To observe whether Graphene oxide (GO) can absorb vitamin B12 (VB12) and Decellularized scaffold - acellular nerve allograft (ANA) modified GO-VB12 promote the repair of ischiadic nervus defects in a rat model.

Methods: The adsorption of GO on vitamin and the optimum adsorption conditions were investigated by single factor experiment. The adsorption properties of the material were observed by scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) to determine the success of adsorption on VB12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1557868DOI Listing

Intracerebroventricular infusion of D-serine decreases nociceptive behaviors induced by electrical stimulation of the dura mater of rat.

Neurol Res 2019 Mar 25;41(3):204-207. Epub 2018 Dec 25.

a Department of neurology , The Chinese PLA general hospital , Beijing , China.

Objective And Method: D-serine acts as an obligatory ligand for the glycine sites of N-methyl-D-aspartate receptors. To investigate its effect on head-facial pain, nociceptive behaviors of rats induced by electrical stimulation of the dura mater were observed after cerebroventricular infusion of D-serine.

Results: Rats in the D-serine infusion group showed significantly fewer nociceptive behaviors, including grooming and head flicking, than rats in the saline infusion group and control rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1531200DOI Listing
March 2019
1 Read

The effect of duloxetine on penicillin-induced epileptiform activity in rats.

Neurol Res 2019 Apr 24;41(4):298-305. Epub 2018 Dec 24.

b Department of Physiology, Faculty of Medicine , Tokat Gaziosmanpasa University , Tokat , Turkey.

Aim: Previous studies showed the existence of a relationship between epilepsy and depression. Duloxetine is a potent and selective inhibitor of serotonin and norepinephrine reuptake (SNRI) used in the treatment of the major depressive disorder. The aim of the present study was to investigate the effect of duloxetine on penicillin-induced epileptiform activity in an experimental rat model of acute partial epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1560642DOI Listing
April 2019
4 Reads

Diffusion tensor tractography to visualize axonal outgrowth and regeneration in a 4-cm reverse autograft sciatic nerve rabbit injury model.

Neurol Res 2019 Mar 24;41(3):257-264. Epub 2018 Dec 24.

a Department of Plastic Surgery , Vanderbilt University Medical Center , Nashville , TN , USA.

Background: Diffusion tensor tractography (DTT) has recently been shown to accurately detect nerve injury and regeneration. This study assesses whether 7-tesla (7T) DTT imaging is a viable modality to observe axonal outgrowth in a 4 cm rabbit sciatic nerve injury model fixed by a reverse autograft (RA) surgical technique.

Methods: Transection injury of unilateral sciatic nerve (4 cm long) was performed in 25 rabbits and repaired using a RA surgical technique. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1554284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435384PMC
March 2019
2 Reads

Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke.

Neurol Res 2019 Apr 21;41(4):289-297. Epub 2018 Dec 21.

a Biotech Research and Innovation Centre , University of Copenhagen , Copenhagen , Denmark.

Objective: In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatment.

Methods: Data from 10 patients already on statins at stroke onset (Pre-S group) was compared with data from both 29 patients starting statin treatment right after stroke onset (Post-S group) and with 8 healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1558000DOI Listing
April 2019
1.449 Impact Factor

Assessment of pre and post-thymectomy myasthenia gravis.

Neurol Res 2019 Mar 21;41(3):275-281. Epub 2018 Dec 21.

a Department of Neuromicrobiology , National Institute of Mental Health and Neurosciences , Bangalore , India.

Objective: To evaluate transcervical and transsternal thymectomy benefits in large myasthenia gravis (MG) cohort.

Method: We retrospectively evaluated MG patients (n = 184) who had undergone thymectomy between 2004 and 2015 at National Institute of Mental Health and Neurosciences, Bangalore (India). Myasthenia gravis foundation of America guidelines were followed to assess clinical outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1557433DOI Listing
March 2019
1 Read

Regenerative activity of Hericium erinaceus on axonal injury model using in vitro laser microdissection technique.

Neurol Res 2019 Mar 20;41(3):265-274. Epub 2018 Dec 20.

b Neuroscience Research Unit, School of Medicine , Van Yüzüncü Yıl University , Van , Turkey.

Objective: Peripheral nerve injury (PNI) is an important global health problem. Nerve Growth Factor (NGF) plays crucial role in the survival, growth, and maintenance of various neurons in the mammalian nervous system, human included. Hericium erinaceus (HE), an edible and medicinal mushroom, has been extensively studied for its neuroprotective properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1556494DOI Listing

Hyperuricemia and prognosis of acute ischemic stroke in diabetic patients.

Neurol Res 2019 Mar 11;41(3):250-256. Epub 2018 Dec 11.

b Department of Neurology , the first Affiliated Hospital of Harbin Medical University , Harbin , China.

Objectives: The relationship between hyperuricemia (HUA) and prognosis of acute ischemic stroke (AIS) is unclear. This prospective cohort study aims to evaluate potential value of HUA as a prognostic factor for AIS independent of diabetic status.

Methods: A total of 1041 consecutive patients aged from 25 to 96 with AIS were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1553347DOI Listing
March 2019
4 Reads

Structural and cognitive correlates of fatigue in progressive multiple sclerosis.

Neurol Res 2019 Feb 4;41(2):168-176. Epub 2018 Dec 4.

a Danish Multiple Sclerosis Centre (DMSC), Department of Neurology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

Background: Fatigue in multiple sclerosis (MS) is a debilitating symptom and experienced by most patients. In recent studies investigating this phenomenon, the majority of patients had a relapsing-remitting disease course.

Methods: Patients with progressive MS participating in one of three treatment trials during a period from 2010 to 2014 were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1547813DOI Listing
February 2019
1 Read