2,297 results match your criteria Neurological History and Physical Examination


Intracranial Hemorrhage in Children With Inherited Bleeding Disorders: A Single Center Study in China.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Intracranial hemorrhage (ICH) is a life-threatening condition in children. Inherited bleeding disorders (IBD) have high risk of ICH.

Aim: This single center study aims to identify the incidence, risk factors, and neurological outcome of ICH in children who suffer from IBD. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001358DOI Listing
December 2018

Atypical cerebral palsy: genomics analysis enables precision medicine.

Genet Med 2018 Dec 13. Epub 2018 Dec 13.

BC Children's Hospital Research Institute, Vancouver, BC, Canada.

Purpose: The presentation and etiology of cerebral palsy (CP) are heterogeneous. Diagnostic evaluation can be a prolonged and expensive process that might remain inconclusive. This study aimed to determine the diagnostic yield and impact on management of next-generation sequencing (NGS) in 50 individuals with atypical CP (ACP). Read More

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http://www.nature.com/articles/s41436-018-0376-y
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http://dx.doi.org/10.1038/s41436-018-0376-yDOI Listing
December 2018
7 Reads

Periodontal Ehlers-Danlos syndrome is associated with leukoencephalopathy.

Neurogenetics 2018 Dec 8. Epub 2018 Dec 8.

Department of Child Neurology and Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Here, we report brain white matter alterations in individuals clinically and genetically diagnosed with periodontal Ehlers-Danlos syndrome, a rare disease characterized by premature loss of teeth and connective tissue abnormalities. Eight individuals of two families clinically diagnosed with periodontal Ehlers-Danlos syndrome were included in the present study and underwent general physical, dental, and neurological examination. Whole exome sequencing was performed, and all patients included in the study underwent MRI of the brain. Read More

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http://link.springer.com/10.1007/s10048-018-0560-x
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http://dx.doi.org/10.1007/s10048-018-0560-xDOI Listing
December 2018
6 Reads

Caroli's-type ductal plate malformation and a portosystemic shunt in a 4-month-old kitten.

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918812329. Epub 2018 Nov 20.

Small Animal Specialist Hospital, Sydney, Australia.

Case Summary: A 4-month-old neutered male Russian Blue kitten had a 4 week history of hypersalivation and failure to thrive. In addition, there was a 2 week history of soft tissue swelling on the ventral abdomen, which had failed to improve with antimicrobial therapy. There were no significant physical examination or neurological deficits on examination; however, the cat had a quiet demeanour for its age. Read More

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http://dx.doi.org/10.1177/2055116918812329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247498PMC
November 2018
1 Read

Neonatal hypotonia: is it a diagnostic challenge?

Rev Neurol 2018 Oct;67(8):287-292

Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal.

Introduction: Hypotonia is a frequent sign of disease in newborns. However, it's a nonspecific clinical finding: may be the presentation form of a systemic or neurological disease.

Aims: To study the main causes of neonatal hypotonia as well as to evaluate the diagnostic accuracy of the anamnesis and physical examination of the hypotonic newborn. Read More

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October 2018
12 Reads

Functional neurological disorders: acute presentations and management.

Clin Med (Lond) 2018 Oct;18(5):414-417

Institute of Molecular and Clinical Sciences, St George's University of London, London, UK

Functional neurological disorders (FND) are common and associated with significant morbidity and healthcare costs. Patients with FND often present acutely, particularly with dissociative seizures (resembling epilepsy) or persistent weakness resembling a stroke. History and careful observation and examination are critical to diagnosis, as investigations will often be normal or non-contributory. Read More

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http://www.clinmed.rcpjournal.org/lookup/doi/10.7861/clinmed
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http://dx.doi.org/10.7861/clinmedicine.18-5-414DOI Listing
October 2018
4 Reads

[Pollution and Chronic Arsenic Poisoning Associated with the Operation of Former Toroku Mine in Takachiho Town, Miyazaki Prefecture].

Authors:
Atsushi Ohtsubo

Nihon Eiseigaku Zasshi 2018 ;73(3):275-276

Environment and Forestry Department, Miyazaki Prefectural Government.

Japan has laws in place that are intended to reduce health risks from environmental pollution, including air pollution. On the basis of the "polluters pay" principle, these laws are designed to support pollution victims. In Miyazaki Prefecture, people were chronically exposed to arsenic in Takachiho Town as a result of the operation of Toroku Mine. Read More

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http://dx.doi.org/10.1265/jjh.73.275DOI Listing
October 2018
2 Reads

Neurosyphilis Presenting with Anxiety: A Case Report.

Cureus 2018 Jul 22;10(7):e3020. Epub 2018 Jul 22.

Surgery Student, West Virginia School of Osteopathic Medicine, Lewisburg , USA.

The number of cases of late and late latent syphilis in the United States is on the rise. This diagnosis is often forgotten when an elderly patient is being worked up for altered mental status. Rarely does a 70-year-old male with neurosyphilis present simply with anxiety. Read More

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http://dx.doi.org/10.7759/cureus.3020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150767PMC
July 2018
8 Reads

The approach of physiatrists to low back pain across Europe.

J Back Musculoskelet Rehabil 2018 Sep 7. Epub 2018 Sep 7.

Department of Rehabilitation Medicine, General Teaching Hospital Prague, Prague, Czech Republic.

Background: Low back pain (LBP) is the most common type of musculoskeletal pain, thus it is one of the most commonly encountered conditions in Physical and Rehabilitation Medicine. The physicians who are primarily responsible for the nonsurgical management of LBP are physiatrists.

Objective: The present study aimed to investigate the approaches of physiatrists to low back pain across Europe. Read More

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http://dx.doi.org/10.3233/BMR-171001DOI Listing
September 2018
2 Reads

Chronic intestinal pseudo-obstruction due to al amyloidosis: a case report and literature review.

Clin J Gastroenterol 2018 Sep 19. Epub 2018 Sep 19.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Minami 1-Jo Nishi 16-Chome, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.

A 59-year-old woman presented to our hospital with a 6-month history of nausea, weight loss, and abdominal distension. Physical examination revealed abdominal distension without tenderness, and edema, numbness, and multiple peripheral neuropathy in the limbs. Blood test results showed anemia, hypoproteinemia, and hypoalbuminemia. Read More

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http://dx.doi.org/10.1007/s12328-018-0909-6DOI Listing
September 2018
1 Read

[Possibilities of diagnostics in unilateral fibular-nerve-paresis in a calf].

Schweiz Arch Tierheilkd 2018 09;160(9):539-545

Klinik für Wiederkäuer mit Ambulanz und Bestandsbetreuung, Ludwig-Maximilians-Universität München.

Introduction: The present case report describes the workup of unilateral fibular-nerve-paresis in a female neonatal Fleckvieh calf. The calf was admitted to the Clinic for Ruminants with Ambulatory and Herd Health Services, Ludwig- Maximilians-University Munich as part of an investigation into a herd problem. The herd problem was presented as movement disorder in neonatal calves with an incidence of 10%. Read More

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http://sat.gstsvs.ch/de/pubmed/?doi=10.17236/sat00175
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http://dx.doi.org/10.17236/sat00175DOI Listing
September 2018
6 Reads

Intellectual Disability and Psychotropic Medications.

J Dev Behav Pediatr 2018 Sep;39(7):591-593

Division of Developmental Behavioral Pediatrics, University of Michigan Medical School, Ann Arbor, MI.

Case: Andrew is a 17-year-old male with trisomy 21, commonly known as Down syndrome, and accompanying severe intellectual disability who presents to your primary care office with his father for the first time to establish care and assistance with transition. Andrew has a history of a complete atrioventricular canal that was repaired as an infant and poorly controlled infantile spasms. Currently, he struggles with constipation, esophageal strictures, medullary nephrocalcinosis, urinary retention, sleep dysregulation, G-tube dependency, and hip dysplasia. Read More

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http://Insights.ovid.com/crossref?an=00004703-900000000-9926
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http://dx.doi.org/10.1097/DBP.0000000000000613DOI Listing
September 2018
13 Reads

Wearables for gait and balance assessment in the neurological ward - study design and first results of a prospective cross-sectional feasibility study with 384 inpatients.

BMC Neurol 2018 Aug 16;18(1):114. Epub 2018 Aug 16.

Department of Neurology and Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University Tübingen, 72076, Tübingen, Germany.

Background: Deficits in gait and balance are common among neurological inpatients. Currently, assessment of these patients is mainly subjective. New assessment options using wearables may provide complementary and more objective information. Read More

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http://dx.doi.org/10.1186/s12883-018-1111-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094895PMC
August 2018
2 Reads

Survival patterns and cancer determinants in families with myotonic dystrophy type 1.

Eur J Neurol 2019 Jan 16;26(1):58-65. Epub 2018 Sep 16.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Background And Purpose: Research indicates that patients with myotonic dystrophy type 1 (DM1) are at increased risk of cancer and early death. Family data may provide insights given DM1 phenotypic heterogeneity, the broad range of non-muscular manifestations and the usual delays in the diagnosis of DM1.

Method: Family history data were collected from 397 genetically and/or clinically confirmed DM1 patients (respondents) enrolled in the US or UK myotonic dystrophy registries. Read More

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http://doi.wiley.com/10.1111/ene.13763
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http://dx.doi.org/10.1111/ene.13763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283697PMC
January 2019
10 Reads

Infection, Immunodeficiency, and Inflammatory Diseases in Autoimmune Neurology.

Semin Neurol 2018 Jun 16;38(3):379-391. Epub 2018 Jul 16.

Department of Neurology, University of Utah, Salt Lake City, Utah.

When patients present with neurological syndromes, such as encephalopathy/encephalitis, meningitis, and/or myelopathy/myelitis, the differential diagnosis is often broad, including infectious, inflammatory, autoimmune, vascular, and neoplastic etiologies. Just with inflammatory and autoimmune etiologies alone, there are numerous causative diseases. A comprehensive history and physical examination investigating for extraneurologic manifestations of immune-mediated disease is often necessary. Read More

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http://dx.doi.org/10.1055/s-0038-1660820DOI Listing
June 2018
4 Reads

Minimally Invasive Microsurgical Resection of Primary, Intradural Spinal Tumors is Feasible and Safe: A Consecutive Series of 83 Patients.

Neurosurgery 2018 Mar;82(3):365-371

Faculty of Medicine, University of Oslo, Oslo, Norway.

Background: To date, the traditional approach to intraspinal tumors has been open laminectomy or laminoplasty followed by microsurgical tumor resection. Recently, however, minimally invasive approaches have been attempted by some.

Objective: To investigate the feasibility and safety of minimally invasive surgery (MIS) for primary intradural spinal tumors. Read More

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http://dx.doi.org/10.1093/neuros/nyx253DOI Listing
March 2018
1 Read

Occipital Headaches and Neuroimaging in Children.

Curr Pain Headache Rep 2018 Jul 10;22(9):59. Epub 2018 Jul 10.

The University of California, San Francisco (UCSF), Department of Neurology, Pediatric Brain Center, Child & Adolescent Headache Program, Mission Hall, Box 0137, 550 16th Street, 4th Floor, San Francisco, California, 94158, USA.

Purpose Of Review: The goal of this review is to outline the prevalence and significance of occipital headaches in children and how they relate to neuroimaging findings. We seek to evaluate the concern that occipital headaches in children are indicative of secondary headache pathology by reviewing the yield of neuroimaging in pediatric patients with occipital headache location.

Recent Findings: Occipital headaches are a common presentation of primary headache disorders in children, seen in 7-16% of children presenting for evaluation of headache and in up to 20% of children diagnosed with migraine in the emergency department. Read More

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http://link.springer.com/10.1007/s11916-018-0712-6
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http://dx.doi.org/10.1007/s11916-018-0712-6DOI Listing
July 2018
21 Reads

Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview.

Eur Spine J 2018 Nov 3;27(11):2791-2803. Epub 2018 Jul 3.

Department of General Practice, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Objective: The aim of this study was to provide an overview of the recommendations regarding the diagnosis and treatment contained in current clinical practice guidelines for patients with non-specific low back pain in primary care. We also aimed to examine how recommendations have changed since our last overview in 2010.

Method: The searches for clinical practice guidelines were performed for the period from 2008 to 2017 in electronic databases. Read More

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http://dx.doi.org/10.1007/s00586-018-5673-2DOI Listing
November 2018
12 Reads

Early urological care of patients with spinal cord injury.

World J Urol 2018 Oct 9;36(10):1537-1544. Epub 2018 Jun 9.

Neuro-Urology, Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

Purpose: After spinal cord injury (SCI), the initial goals of urological management include maintaining safe storage of urine with efficient bladder emptying, maximising urinary continence, and minimising the risk of urological complications.

Methods: This review was performed according to the methodology recommended by the Joint SIU-ICUD International Consultation. Embase and Medline databases were used to identify literature relevant to the early urological care of SCI patients. Read More

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http://link.springer.com/10.1007/s00345-018-2367-7
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http://dx.doi.org/10.1007/s00345-018-2367-7DOI Listing
October 2018
16 Reads

Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography.

JAMA Neurol 2018 Oct;75(10):1198-1205

National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust NHS Foundation Trust and UCL Institute of Ophthalmology, London, England.

Importance: Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia.

Objective: To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people.

Design, Setting, And Participants: UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 years at enrollment who underwent baseline retinal optical coherence tomography imaging, a physical examination, and a questionnaire. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.1578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233846PMC
October 2018

Could an increase in vigilance for spinal tuberculosis at primary health care level, enable earlier diagnosis at district level in a tuberculosis endemic country?

Afr J Prim Health Care Fam Med 2018 Jun 18;10(1):e1-e9. Epub 2018 Jun 18.

Private Practice,Centani.

Background: Expert clinicians and researchers in the field of spinal tuberculosis (STB) advocate for early identification and diagnosis as a key to reducing disability, severity of disease, expensive surgery and death, especially in tuberculosis (TB) endemic countries like South Africa. South Africa has the highest incidence per capita of tuberculosis in the world, and a conservative estimate of the incidence of STB in South Africa is 8-16:100 000. People living with STB may initially present to primary health care (PHC) centres, where the opportunity exists for early identification. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018652PMC
http://dx.doi.org/10.4102/phcfm.v10i1.1666DOI Listing
June 2018
10 Reads

Ulcerative colitis with Guillain-Barré syndrome: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11013

Department of Gastroenterology.

Rationale: Ulcerative colitis is a chronic and recurrent inflammatory disease involving the intestine. It is reported that about 40% of patients with ulcerative colitis have extraintestinal manifestations, where as the literature on neurological involvement as extraintestinal manifestation is rather limited. Guillain-Barré syndrome is an abnormal immune-mediated and acute-acquired demyelinating disease that mainly affects the peripheral nervous system and often has a phenomenon of protein-cell separation of cerebrospinal fluid. Read More

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http://dx.doi.org/10.1097/MD.0000000000011013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024027PMC

Expanding spectrum of 2 gene disorders: Myoclonic epilepsy, mental retardation, spasticity, and extrapyramidal features.

Epilepsia Open 2018 Jun 23;3(2):270-275. Epub 2018 Mar 23.

Department of Neurology St. John's Medical College Hospital Bengaluru Karnataka India.

Pontocerebellar hypoplasia type 6 (PCH6) is an autosomal recessive mitochondrial disease, typically characterized by pontine atrophy, vermian hypoplasia, infantile encephalopathy, generalized hypotonia, and intractable seizures. The purpose of this study is to describe the seizures and other neurological manifestations of 2 gene mutations and to compare the clinical features with other causes of progressive myoclonic epilepsy. Detailed history, physical examination, and clinical and genetic work-up were performed in 2 siblings who presented with progressive myoclonic epilepsy. Read More

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http://dx.doi.org/10.1002/epi4.12108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983106PMC
June 2018
23 Reads

Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study.

Neurol Sci 2018 Aug 28;39(8):1345-1353. Epub 2018 May 28.

Pharmaceutical Sciences Research Center, and Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Phytotherapy is a source of finding new remedies for migraine. Traditional chamomile oil (chamomile extraction in sesame oil) is a formulation in Persian medicine (PM) for pain relief in migraine. An oleogel preparation of reformulated traditional chamomile oil was prepared and then standardized based on chamazulene (as a marker in essential oil) and apigenin via gas chromatography (GC) and high-performance liquid chromatography (HPLC) methods, respectively. Read More

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http://dx.doi.org/10.1007/s10072-018-3415-1DOI Listing
August 2018
4 Reads

Spinal tophaceous gout presenting in a young adult without pain.

BMJ Case Rep 2018 May 26;2018. Epub 2018 May 26.

Department of Internal Medicine, University at Buffalo Catholic Health, Buffalo, New York, USA.

A 26-year-old man with a medical history of gout and morbid obesity presented with a 7-day history of decreased sensation to light touch and temperature from the feet to the level of the nipples. He also noted incomplete voiding. Laboratory investigations showed an elevated serum uric acid level (10. Read More

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http://dx.doi.org/10.1136/bcr-2018-224406DOI Listing
May 2018
9 Reads

Diagnostic yield of neuroimaging in syncope patients without high-risk symptoms indicating neurological syncope.

Am J Emerg Med 2018 May 16. Epub 2018 May 16.

Department of Emergency Medicine, Tepecik Training and Research Hospital, Turkey.

Objectives: Diagnostic tests are widely used for patients with syncope in the emergency department (ED). This study aimed to determine the diagnostic yield of neuroimaging in patients with syncope without high-risk symptoms.

Methods: Adult patients who presented to the ED with syncope in 2016 were screened retrospectively. Read More

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http://dx.doi.org/10.1016/j.ajem.2018.05.033DOI Listing

Dynamical Properties of Postural Control in Obese Community-Dwelling Older Adults .

Sensors (Basel) 2018 May 24;18(6). Epub 2018 May 24.

Muhammad Ali Parkinson Center (MAPC), Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.

Postural control is a key aspect in preventing falls. The aim of this study was to determine if obesity affected balance in community-dwelling older adults and serve as an indicator of fall risk. The participants were randomly assigned to receive a comprehensive geriatric assessment followed by a longitudinal assessment of their fall history. Read More

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http://dx.doi.org/10.3390/s18061692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021983PMC

Preliminary Use of the Physical and Neurological Examination of Subtle Signs for Detecting Subtle Motor Signs in Adolescents With Sport-Related Concussion.

Am J Phys Med Rehabil 2018 Jun;97(6):456-460

From the Kennedy Krieger Institute, Baltimore, Maryland (JAS, MBD, BSS, EMM, SJS); Department of Physical Medicine and Rehabilitation (JAS, SJS), Department of Neurology (MBD), Department of Psychiatry (MBD), Department of Pediatrics (TM, BSS, SJS), and Department of Psychiatry and Behavioral Sciences (BSS, EMM), Johns Hopkins School of Medicine, Baltimore, Maryland; and Department of Occupational Therapy, Colorado State University, Fort Collins (JAS).

Sensitive examination tools are needed to optimize evaluation after sports-related concussion. The Physical and Neurological Examination of Subtle Signs was preliminarily examined for sensitivity to motor changes in a pilot cohort of adolescents aged 13-17 yrs with sports-related concussion. A total of 15 adolescents (5 female adolescents) with sports-related concussion were evaluated up to three times: within 2 wks of injury, approximately 1 mo later (mean, 35 days between visits), and for those not recovered at the second visit, again after clinical recovery (mean, 70 days between the first and last visits for all participants). Read More

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http://dx.doi.org/10.1097/PHM.0000000000000906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987775PMC

[Neonatal facial palsy: identification of herpes simplex virus 1 in cerebrospinal fluid. Case report].

Arch Argent Pediatr 2018 06;116(3):e468-e470

Hospital Universitario Puerta del Mar. Cádiz, España.

Neonatal facial palsy is very uncommon and is generally diagnosed at birth. We present the first published case of neonatal facial palsy with identification of herpes simplex virus 1 in cerebrospinal fluid. A 35-day-old male was presented at the Emergency Department with mouth deviation to the left and impossibility of full closure of the right eye. Read More

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http://dx.doi.org/10.5546/aap.2018.e468DOI Listing
June 2018
1 Read

Motor neuron disease of paraneoplastic origin: a rare but treatable condition.

J Neurol 2018 Jul 3;265(7):1590-1599. Epub 2018 May 3.

Département de Neurophysiologie clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

Paraneoplastic motor neuron disorders (MND) are rare conditions; their exact clinical and electrophysiological phenotype have not been exhaustively described yet. The purpose of this study is to depict the main characteristics of paraneoplastic MND to highlight the features that may allow its diagnosis. Based on the description of eight original cases, and on the revision of 21 patients identified from a systematic review of the literature, the main features of paraneoplastic MND can be summarized as follows: (1) subacute; (2) lower motor neuron syndrome, associated or not with upper motor neuron involvement; (3) predominant asymmetric upper limb involvement; (4) presence of other non-motor neurological manifestations, including sensory neuronopathy; (5) signs of inflammation in the cerebrospinal fluid (CSF); (6) neurological improvement or stabilization after immunotherapy and tumor treatment. Read More

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http://dx.doi.org/10.1007/s00415-018-8881-0DOI Listing
July 2018
3 Reads

Analysis of Risk Factors in Patients With Peripheral Vertigo or Central Vertigo.

Neurologist 2018 May;23(3):75-78

Otology, First Hospital of Qinhuangdao, Qinhuangdao, China.

Introduction: This study was aimed to determine risk factors for central vertigo (CV) in patients with isolated vertigo accompanied by hearing loss or not.

Patients And Methods: Patients with CV or peripheral vertigo (PV) who were admitted to our hospital between January 2014 and July 2016 were retrospectively reviewed. All patients underwent thorough physical examination with detailed medical histories recorded, including smoking, hypertension, diabetes, cardiovascular disease, and stroke history. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000179DOI Listing
May 2018
13 Reads

Long-term neurological and neuropsychological complications of sulfur mustard and Lewisite mixture poisoning in Chinese victims exposed to chemical warfare agents abandoned at the end of WWII.

Toxicol Lett 2018 Sep 24;293:9-15. Epub 2018 Apr 24.

Department of Neurology, Usioda General Hospital, Yokohama, Japan.

In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We carried out a total of six regular check-ups between 2006 and 2014, and from 2008 we added neurological evaluations including neuropsychological test and autonomic nervous function test in parallel with medical follow-up as much as was possible. Read More

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http://dx.doi.org/10.1016/j.toxlet.2018.04.017DOI Listing
September 2018
8 Reads

Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer.

Cir Cir 2018 ;86(1):79-83

Medicina de Rehabilitación, Facultad de Medicina, Universidad de Guanajuato. León, Gto., México.

Background: Neurological paraneoplastic syndromes are rare, occur in 0.01% of all cancer patients; like part of them, the Lambert-Eaton syndrome is an autoimmune presynaptic disorder of neuromuscular transmission characterized by muscle weakness and neurovegetative dysfunction, and often associated with small cell lung cancer.

Case Report: A 72 years old female with a family history of lung cancer and leukemia, with 7 months of dry cough and 3 months with waist and pelvic muscle weakness, oropharyngeal dysphagia, dry mouth, chronic constipation and weight loss of 10 kg. Read More

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http://dx.doi.org/10.24875/CIRU.M18000006DOI Listing
November 2018
13 Reads

Technology-enabled examinations of cardiac rhythm, optic nerve, oral health, tympanic membrane, gait and coordination evaluated jointly with routine health screenings: an observational study at the 2015 Kumbh Mela in India.

BMJ Open 2018 04 20;8(4):e018774. Epub 2018 Apr 20.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Objectives: Technology-enabled non-invasive diagnostic screening (TES) using smartphones and other point-of-care medical devices was evaluated in conjunction with conventional routine health screenings for the primary care screening of patients.

Design: Dental conditions, cardiac ECG arrhythmias, tympanic membrane disorders, blood oxygenation levels, optic nerve disorders and neurological fitness were evaluated using FDA-approved advanced smartphone powered technologies. Routine health screenings were also conducted. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-018774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914894PMC
April 2018
7 Reads

Pediatric Head Injury: A Study of 403 Cases in a Tertiary Care Hospital in a Developing Country.

J Pediatr Neurosci 2017 Oct-Dec;12(4):332-337

Department of Anaesthesiology, Sher-I Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Introduction: Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldwide. Falls are the most common type of injury, followed by motor vehicle-related accidents and child abuse.

Aims And Objectives: The aim and objective of this study was to elucidate the various modes of injury, prognostic factors, complications, incidence of various modes of injury, and outcome in TBI in pediatric population. Read More

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http://dx.doi.org/10.4103/jpn.JPN_80_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890552PMC
April 2018
1 Read

The course of awake breathing disturbances across the lifespan in Rett syndrome.

Brain Dev 2018 Aug 12;40(7):515-529. Epub 2018 Apr 12.

University of Alabama at Birmingham, AL, United States.

Rett syndrome (RTT), an X-linked dominant neurodevelopmental disorder caused by mutations in MECP2, is associated with a peculiar breathing disturbance exclusively during wakefulness that is distressing, and can even prompt emergency resuscitation. Through the RTT Natural History Study, we characterized cross sectional and longitudinal characteristics of awake breathing abnormalities in RTT and identified associated clinical features. Participants were recruited from 2006 to 2015, and cumulative lifetime prevalence of breathing dysfunction was determined using the Kaplan-Meier estimator. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026556PMC
August 2018
12 Reads

Neurofilament light protein levels in cerebrospinal fluid predict long-term disability of Guillain-Barré syndrome: A pilot study.

Acta Neurol Scand 2018 Aug 6;138(2):143-150. Epub 2018 Apr 6.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: Although the recovery from Guillain-Barré syndrome (GBS) is good in most patients, some develop permanent severe disability or even die. Early predictors would increase the likelihood to identify patients at risk for poor outcome at the acute stage, allowing them intensified therapeutic intervention.

Materials And Method: Eighteen patients with a history of GBS 9-17 years ago were reassessed with scoring of neurological disability and quality of life assessment (QoL). Read More

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http://doi.wiley.com/10.1111/ane.12927
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http://dx.doi.org/10.1111/ane.12927DOI Listing
August 2018
1 Read

Quality of care for patients with diabetes done by family medicine team during the period 2013-2016.

Med Glas (Zenica) 2018 Aug;15(2):199-204

Family Medicine Teaching Centre, Primary Health Care Zenica, Zenica, Bosnia and Herzegovina.

Aim To assess whether the quality of diabetes care provided by a family medicine team changed over the course of four years and to identify potential gaps in our practice in order to improve it in the future. Methods An audit was carried out for randomly selected 120 medical records (MC) from the Diabetes Registry of patients with type 1 or 2 diabetes mellitus treated by one family medicine team for four consecutive years, from 2013 to 2016. We examined demographic data (gender, age, diabetes type, family history), annual examinations (glycated haemoglobin, blood glucose, lipid profile, neurological examination, urinalysis, foot care, ocular fundus and body mass index), prescribed insulin or other drugs and patients' education. Read More

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http://dx.doi.org/10.17392/934-18DOI Listing
August 2018
1 Read

Clinical characteristics of Spirocerca lupi migration in the spinal cord.

Vet Parasitol 2018 Apr 15;253:16-21. Epub 2018 Feb 15.

Koret School of Veterinary Medicine, Veterinary Teaching Hospital, Hebrew University of Jerusalem, P.O. Box 12, Rehovot, 76100, Israel.

Spirocerca lupi is a nematode infecting dogs mostly in tropical and subtropical areas. Although its typical target is the esophageal wall, aberrant migration is not uncommon, including migration of unknown incidence into the spinal cord. While successful treatment of intraspinal S. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.02.025DOI Listing
April 2018
2 Reads

[Chronic prurigo].

Hautarzt 2018 Apr;69(4):321-330

Kompetenzzentrum Chronischer Pruritus (KCP), Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland.

Chronic prurigo is a disease characterized by the presence of chronic pruritus and singular or multiple usually hyperkeratotic symmetrically distributed itchy papules, nodules, and/or plaques. This condition is difficult to treat and leads to a substantial impairment of the quality of life. It may originate from dermatological, systemic, neurological, psychiatric/psychosomatic, multifactorial or unknown conditions causing itch, which lead to prolonged scratching behavior and sensitization mechanisms and ultimately to the development of pruriginous lesions. Read More

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http://dx.doi.org/10.1007/s00105-018-4145-2DOI Listing

Stunting, wasting, and mid upper arm circumference status among children admitted to Nemazee Teaching Hospital.

Nutr Hosp 2018 Jan 10;35(1):33-37. Epub 2018 Jan 10.

.

Introduction And Aim: The aim of this study was to evaluate nutritional status in children without prior hospital admission or evidence of chronic disease.

Subjects And Methods: The current study is a cross-sectional and observational study which was conducted for assessing the nutritional status of children. In this study, consecutive sampling was used, with a sample size about 400 children aged 6 months to 18 years at first hospital admission. Read More

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http://dx.doi.org/10.20960/nh.1143DOI Listing
January 2018
8 Reads

Painful torticollis following adenotonsillectomy: a cardinal sign of atlantoaxial subluxation.

BMJ Case Rep 2018 Mar 1;2018. Epub 2018 Mar 1.

Department of Otolaryngology, St George's Hospital, London, UK.

An 11-year-old boy with a history of autism spectrum disorder attended the emergency department with his mother 8 days after an adenotonsillectomy reporting postoperative bleeding. Detailed physical examination revealed no active bleeding, but a rigid neck posture was noted. A head and neck CT scan demonstrated unilateral rotatory atlantoaxial subluxation and possible damage to the anterior spinal ligament. Read More

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http://dx.doi.org/10.1136/bcr-2017-223567DOI Listing
March 2018
13 Reads

The Global Spine Care Initiative: a systematic review for the assessment of spine-related complaints in populations with limited resources and in low- and middle-income communities.

Eur Spine J 2018 Sep 28;27(Suppl 6):816-827. Epub 2018 Feb 28.

Department of Neurological Surgery, Başkent University School of Medicine, Ankara, Turkey.

Purpose: The purpose of this systematic literature review was to develop recommendations for the assessment of spine-related complaints in medically underserved areas with limited resources.

Methods: We conducted a systematic review and best evidence synthesis of guidelines on the assessment of spine-related complaints. Independent reviewers critically appraised eligible guidelines using the Appraisal of Guidelines for Research and Evaluation-II criteria. Read More

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http://link.springer.com/10.1007/s00586-017-5446-3
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http://dx.doi.org/10.1007/s00586-017-5446-3DOI Listing
September 2018
12 Reads
2.470 Impact Factor

Sudden Onset of Severe Cervical Pain in an Adolescent Girl: Case Report and Review of Literature.

Pediatr Emerg Care 2018 Feb 28. Epub 2018 Feb 28.

A previously healthy 13-year-old girl presented with a 9-day history of acute onset severe neck pain associated with limited range of movement. Medical evaluation at day 2 was suggestive of muscle contracture, and she was discharged home with diazepam, antiinflammatory agents, and rest; however, she returned because of progressive clinical worsening with left arm distal paresthesia and paralysis since day 3. There was no history of trauma or other systemic complaints, and her familial medical history was unremarkable. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001437DOI Listing
February 2018
2 Reads

The adverse effects of oral desmopressin lyophilisate (MELT): personal experience on enuretic children.

Turk J Urol 2018 Jan 8;44(1):51-55. Epub 2018 Jan 8.

Public Health and Statistics, Campus Bio-Medico University, Rome, Italy.

Objective: The aim of this study was to evaluate adverse effects of oral desmopressin lyophilisate (MELT) in enuretic children.

Material And Methods: We enrolled 260 children with nocturnal enuresis (NE) referred to the Pediatric Service, 'Campus Bio-Medico' University of Rome, from April 2014 to April 2017 in the study, of these 23 were excluded. The study was characterized by 2 phases. Read More

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http://dx.doi.org/10.5152/tud.2018.03285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821283PMC
January 2018
2 Reads

NINDS Common Data Elements for Congenital Muscular Dystrophy Clinical Research: A National Institute for Neurological Disorders and Stroke Project.

J Neuromuscul Dis 2018;5(1):75-84

The EMMES Corporation, Rockville, MD, USA.

Background: A Congenital Muscular Dystrophy (CMD) Working Group (WG) consisting of international experts reviewed common data elements (CDEs) previously developed for other neuromuscular diseases (NMDs) and made recommendations for all types of studies on CMD.

Objectives: To develop a comprehensive set of CDEs, data definitions, case report forms and guidelines for use in CMD clinical research to facilitate interoperability of data collection, as part of the CDE project at the National Institute of Neurological Disorders and Stroke (NINDS).

Methods: One working group composed of ten experts reviewed existing NINDS CDEs and outcome measures, evaluated the need for new elements, and provided recommendations for CMD clinical research. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JND-170248DOI Listing
June 2018
16 Reads

Effects of tooth loss on brain structure: a voxel-based morphometry study.

J Prosthodont Res 2018 Jul 21;62(3):337-341. Epub 2018 Feb 21.

Department of Prosthodontics and Oral Implantology, School of Dentistry, Iwate Medical University, Morioka, Japan,. Electronic address:

Purpose: One of the most prominent issues in a super-aging society is the rapid increase in dementia patients. Cross-sectional studies in dentistry have indicated that patients with dementia have worse oral health compared to healthy people. The purpose of this study was to clarify the influence of tooth loss on brain structure by comparing the volumes of gray matter (GM) and white matter (WM) between edentulous and dentulous subjects. Read More

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http://dx.doi.org/10.1016/j.jpor.2017.12.007DOI Listing

A screening method to distinguish syndromic from sporadic spinal extradural arachnoid cyst.

J Orthop Sci 2018 May 16;23(3):455-458. Epub 2018 Feb 16.

Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, 108-8639, Japan. Electronic address:

Background: Spinal extradural arachnoid cyst (SEDAC) is a cystic lesion that protrudes into the epidural space from a small dural defect. Early diagnosis of SEDAC is important because its expansion causes neurological damage. Two types of SEDAC, syndromic and sporadic, are present. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09492658183003
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http://dx.doi.org/10.1016/j.jos.2018.01.010DOI Listing
May 2018
12 Reads
1.010 Impact Factor

The screening process of a patient with low back pain and suspected thoracic myelopathy: a case report.

J Man Manip Ther 2018 Feb 23;26(1):11-17. Epub 2017 Jan 23.

School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia.

Background: Thoracic disc herniations are rare and difficult to diagnose. Myelopathy is a potential consequence that can lead to irreversible neurological impairment if not treated appropriately. It is incumbent on all clinicians who see patients with low back pain (LBP) to be aware of such pathologies. Read More

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http://dx.doi.org/10.1080/10669817.2017.1282189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810765PMC
February 2018

The Factors Affecting the Difficulty of Percutaneous Cylindrical Electrode Placement for Spinal Cord Stimulation.

World Neurosurg 2018 May 14;113:e391-e398. Epub 2018 Feb 14.

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Objective: Optimal placement of electrodes is important for spinal cord stimulation. Factors affecting the difficulty of percutaneous electrode placement are not well known. In this study, we retrospectively evaluated the factors affecting the difficulty of percutaneous electrode placement. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.02.040DOI Listing
May 2018
3 Reads