2,489 results match your criteria Neurological History and Physical Examination


Late-Onset Tethered Cord Syndrome in a Patient with Spina Bifida: A Case Report.

Sisli Etfal Hastan Tip Bul 2018 29;52(2):138-141. Epub 2018 May 29.

Department of Physical Medicine and Rehabilitation, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.

Tethered cord is a clinical syndrome associated with short and thick filum terminale. It can occur because of congenital or acquired reasons and can lead to progressive neurological deficits. A thorough medical history, physcial examination, imaging, and electrophysiological tests are heplful in its diagnosis. Read More

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http://dx.doi.org/10.14744/SEMB.2017.64936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315062PMC

Frequency of Human Immunodeficiency Virus in Patients Admitted with Acute Stroke.

Cureus 2020 May 26;12(5):e8296. Epub 2020 May 26.

Neurology, University Hospital Cleveland Medical Center, Cleveland, USA.

Introduction Stroke is a leading cause of chronic disability and death in both developing and developed countries. A significant proportion of stroke patients are human immunodeficiency virus (HIV) positive. About half of the HIV patients experience some sort of neurological deficit in their lifetimes. Read More

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http://dx.doi.org/10.7759/cureus.8296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317133PMC

Silent Cerebral Infarct in Sickle Cell Anemia Patients of South Turkey.

Turk J Med Sci 2020 Jun 30. Epub 2020 Jun 30.

Background/aim: Silent cerebral infarct (SCI) is an ischemic lesion seen before clinical signs of brain infarct and ischemic changes in brain tissue. This study aimed to detect SCI with non-invasive methods and to determine releated risk factors in patients with sickle cell anemia (SCA).

Materials And Methods: Fifty-four SCA patients who had no history of cerebral infarct and whose neurological examinations were normal, were included in this study. Read More

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http://dx.doi.org/10.3906/sag-2003-192DOI Listing

Whipple disease diagnosed by enteroscopy: first case report in Colombia of an underdiagnosed disease and literature review.

BMC Gastroenterol 2020 Jun 23;20(1):197. Epub 2020 Jun 23.

Gastroenterology and Hepatology Department, Digestive Endoscopy Section, Fundación Santa Fe de Bogotá and Universidad de los Andes Medical School, Bogotá D.C., Colombia.

Background: Whipple's disease is a rare systemic disease caused by a gram-positive bacillus called Tropheryma whipplei. First described in 1907 as an intestinal lipodystrophy with histological finding of vacuoles in the macrophages of the intestinal mucous. Usually the symptoms are localized according to the compromised organ. Read More

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http://dx.doi.org/10.1186/s12876-020-01302-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310292PMC

Inadequacies of the Lasègue test, and how the Slump and Bowstring tests are useful for the diagnosis of sciatica.

Joint Bone Spine 2020 Jun 16. Epub 2020 Jun 16.

Service de Rhumatologie, Hôtel-Dieu, CHU Nantes, 44093 Nantes Cedex 01, France.

Diagnosis of sciatica mainly relies on pain reproduction by stretching of the lumbar roots since neurological examination and medical history are usually not sufficient to guarantee diagnosis. The Lasègue test is the most popular method, which starts with the straight leg raising test (SLR). However it is not perfect, and is not always well performed or interpreted. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.06.004DOI Listing

Clinical findings in families with chordoma with and without T gene duplications and in patients with sporadic chordoma reported to the Surveillance, Epidemiology, and End Results program.

J Neurosurg 2020 Jun 19:1-10. Epub 2020 Jun 19.

1Division of Cancer Epidemiology & Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda.

Objective: To gain insight into the role of germline genetics in the development of chordoma, the authors evaluated data from 2 sets of patients with familial chordoma, those with and without a germline duplication of the T gene (T-dup+ vs T-dup-), which was previously identified as a susceptibility mechanism in some families. The authors then compared the patients with familial tumors to patients with sporadic chordoma in the US general population reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program through 2015.

Methods: Evaluation of family members included review of personal and family medical history, physical and neurological examination, and pre- and postcontrast MRI of the skull base and spine. Read More

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http://dx.doi.org/10.3171/2020.4.JNS193505DOI Listing

Guillain-Barré syndrome following COVID-19: a newly emerging post-infectious complication.

BMJ Case Rep 2020 Jun 14;13(6). Epub 2020 Jun 14.

Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.

A 57-year-old man presented with a progressive flaccid symmetrical motor and sensory neuropathy following a 1-week history of cough and malaise. He was diagnosed with Guillain-Barré syndrome secondary to COVID-19 and started on intravenous immunoglobulin. He proceeded to have worsening respiratory function and needed intubation and mechanical ventilation. Read More

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http://dx.doi.org/10.1136/bcr-2020-236182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298664PMC

Correlation of MMP-9 and HMGB1 expression with the cognitive function in patients with epilepsy and factors affecting the prognosis.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 8;66(3):39-47. Epub 2020 Jun 8.

Department of Neurosurgery, Jiaxiang People's Hospital, Jining 272400, China.

This study was designed to investigate the expressions and roles of MMP-9 and HMGB1 in peripheral blood of patients with epilepsy and their relationship with the cognitive function and to explore factors affecting the prognosis of epilepsy patients. A total of 127 patients with epilepsy were collected in the study group and 120 healthy subjects receiving a physical examination at the same time were collected in the control group. The MMP-9 and HMGB1 expressions and their diagnostic value for epilepsy were compared between the two groups. Read More

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Clinical predictors of significant intracranial computed tomography scan findings in adults experiencing headache disorder.

Pan Afr Med J 2020 19;35:81. Epub 2020 Mar 19.

Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.

Introduction: Radiological assessments for adult headache disorder show significant intracranial findings in 2.5% to 10% of performed computed tomography scans (CT-scans), leading to an overuse consideration for CT-scan requests by physicians in headache-experiencing patients. Therefore, we undertook this study in order to determine predictors of significant intracranial CT-scan findings in adults experiencing headache disorder; in order to help physicians better select patients who need imaging, which would subsequently decrease the costs of headache disorder management and the useless irradiation rates. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.81.16041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250222PMC

Charcot in the ICU: functional tetraplegia after surgery.

Pract Neurol 2020 Jun 12. Epub 2020 Jun 12.

Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Functional neurological disorder is a condition in which a patient has physical findings that are not compatible with anatomical boundaries, have no structural substrate and are not representable of an established disease. General anaesthesia and surgery have been previously reported as precipitating factors for functional disorders and mostly involve dissociative (non-epileptic) seizures. We report a patient with no psychiatric history or prior abnormal examination who developed sudden-onset functional tetraplegia and sensory disturbances immediately after elective surgery, and who was subsequently discharged home several days later after nearly complete resolution of neurologic deficits. Read More

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http://dx.doi.org/10.1136/practneurol-2020-002601DOI Listing

Neurological Complications and Associated Risk Factors in Children Affected with Chronic Kidney Disease.

Children (Basel) 2020 Jun 8;7(6). Epub 2020 Jun 8.

Faculty of Medicine Department, King AbdulAziz University Hospital, P.O.BOX 80215, Jeddah 21589, Saudi Arabia.

To investigate the correlation between chronic kidney disease (CKD) and the development of neurological disease among pediatric patients in Saudi Arabia. The present retrospective study recruited patients admitted to King Abdulaziz University Hospital during 2018. We reviewed electronic records to collect data on essential demographics including age, gender, and nationality; history of prior CNS disease or related symptoms; results of neurological physical examination; and findings of radiological investigations such as abdominal ultrasound, dimercaptosuccinic acid scan, micturating cystourethrogram, diethylene triamine pentaacetic acid scan, brain computed tomography, and magnetic resonance imaging. Read More

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http://dx.doi.org/10.3390/children7060059DOI Listing

Clinical and Genetic Overview of Paroxysmal Movement Disorders and Episodic Ataxias.

Int J Mol Sci 2020 May 20;21(10). Epub 2020 May 20.

Unit of Neuromuscular and Neurodegenerative Diseases, Department of Neuroscience and Neurorehabilitation, IRCCS Bambino Gesù Children's Hospital, 00146 Rome, Italy.

Paroxysmal movement disorders (PMDs) are rare neurological diseases typically manifesting with intermittent attacks of abnormal involuntary movements. Two main categories of PMDs are recognized based on the phenomenology: Paroxysmal dyskinesias (PxDs) are characterized by transient episodes hyperkinetic movement disorders, while attacks of cerebellar dysfunction are the hallmark of episodic ataxias (EAs). From an etiological point of view, both primary (genetic) and secondary (acquired) causes of PMDs are known. Read More

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http://dx.doi.org/10.3390/ijms21103603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279391PMC
May 2020
2.862 Impact Factor

Severe meningoencephalitis secondary to calvarial invasion of forma in a dog.

Open Vet J 2020 Apr 19;10(1):31-38. Epub 2020 Feb 19.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611-0880, USA.

Background: The oomycete forma is an uncommon cause of severe dermal and subcutaneous infections in dogs with possible vascular invasion and other fatal sequelae. Infection within the central nervous system of affected dogs has not been previously reported.

Case Description: A 6-year-old spayed female mixed-breed dog was evaluated at a referral institution with a 2-month history of suspected fungal infection in the region of the right mandibular lymph node that was refractory to surgical resection and empiric medical therapy. Read More

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http://dx.doi.org/10.4314/ovj.v10i1.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193878PMC

Natural history of incidentally diagnosed brainstem cavernous malformations in a prospective observational cohort.

Neurosurg Rev 2020 May 12. Epub 2020 May 12.

Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

There was a lack of natural history of incidental brainstem cavernous malformations (CMs), hemorrhage of which would lead to severe neuropathies. The study aimed to evaluate the prospective hemorrhage rate and neurological outcome of the disease. This prospective cohort included patients with incidental brainstem CMs referred to our institute from 2009 to 2015. Read More

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http://dx.doi.org/10.1007/s10143-020-01308-0DOI Listing

Assessment of cognitive functions and adaptive behavior in children with end-stage renal disease on regular hemodialysis.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):395-406

Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Gharbia Governate, Egypt.

Chronic kidney disease (CKD) is defined by the Kidney Disease and Outcome Quality Initiative as a child who has kidney damage lasting for at least three months with or without decreased glomerular filtration rate. Hemodialysis (HD) means removal of waste products and extra fluid directly from the blood when the kidneys do not work properly. Studies aimed at investigating neurocognitive impairment in children with CKD have identified a wide range of delays in cognitive development. Read More

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http://dx.doi.org/10.4103/1319-2442.284014DOI Listing

Hiccups: A Non-Systematic Review.

Curr Pediatr Rev 2020 May 8. Epub 2020 May 8.

Department of Paediatrics, The Chinese University of Hong Kong, and Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital. Hong Kong.

Background: Hiccups are a universal phenomenon. They are usually benign and self-limited. Persistent or intractable hiccups, although rare, can be debilitating and may indicate the presence of an underlying pathological process. Read More

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http://dx.doi.org/10.2174/1573396316666200508112951DOI Listing

131 A Marionettist Pulling My Strings: A Case of Buprenorphine-induced Chorea.

CNS Spectr 2020 Apr;25(2):282-283

Illinois Center for Neurological and Behavioral Medicine, Des Plaines, Illinois.

Introduction: Choreaform movements provoked by opiates is an infrequent adverse event. Buprenorphine induction of chorea has not heretofore been described. Such a case is presented. Read More

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http://dx.doi.org/10.1017/S1092852920000474DOI Listing

A febrile old man with xanthochromic hypoglycorrhachia.

Germs 2020 Mar 2;10(1):55-57. Epub 2020 Mar 2.

MD, Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.

Introduction: Meningitis is a commonly seen disease in the daily practice of emergency departments. Cerebrospinal fluid (CSF) examination including Gram stain and culture are crucial for identifying between bacterial and viral meningitis and should be completed prior to antibiotic administration. Hypoglycorrhachia is one of the certain independent predictors of bacterial meningitis. Read More

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http://dx.doi.org/10.18683/germs.2020.1186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117881PMC

Orbital myxoma: A case report.

Surg Neurol Int 2020 13;11:43. Epub 2020 Mar 13.

Department of Plastic Surgery, University of Kansas Medical Center, Kansas City, Kansas.

Background: Myxomas are rare, locally infiltrative, benign neoplasms of mesenchymal origin. Although benign, these tumors are locally aggressive with a high rate of recurrence following conservative resection. Their relative infrequency, variable location, and insidious growth present a diagnostic challenge to clinicians. Read More

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http://dx.doi.org/10.25259/SNI_323_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110406PMC

Decision Tree Clinical Algorithm for Screening of Mild Cognitive Impairment in the Elderly in Primary Health Care: Development, Test of Accuracy, and Time-Effectiveness Analysis.

Neuroepidemiology 2020 2;54(3):243-250. Epub 2020 Apr 2.

Department of Neurology, Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.

Mild cognitive impairment (MCI) is predicted to be a common cognitive impairment in primary health care. Early detection and appropriate management of MCI can slow the rate of deterioration in cognitive deficits. The current methods for early detection of MCI have not been satisfactory for some doctors in primary health care. Read More

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http://dx.doi.org/10.1159/000503830DOI Listing

A Young Patient Presenting with Atrioventricular Block Diagnosed as Myotonic Dystrophy.

Intern Med 2020 Jun 19;59(12):1531-1533. Epub 2020 Mar 19.

The Second Department of Internal Medicine, University of Toyama, Japan.

We encountered a 42-year-old woman with a history of diabetes mellitus and cataracts presenting with repeated syncope whose electrocardiogram showed advanced atrioventricular block. On admission, we excluded major potential differential diagnoses as causes of an atrioventricular block but did not suspect myotonic dystrophy, which was eventually diagnosed by chance based on a suspected weakness of the respiratory muscles followed by a detailed neurological physical examination. Myotonic dystrophy should be suspected as a differential diagnosis when relatively young patients present with conductance disorder. Read More

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http://dx.doi.org/10.2169/internalmedicine.4259-19DOI Listing

A Case of Subclavian Artery Thrombosis.

Cureus 2020 Feb 1;12(2):e6842. Epub 2020 Feb 1.

Internal Medicine, Fatima Jinnah Medical University, Lahore, PAK.

Subclavian artery thrombosis is a rare cause of upper limb ischemia resulting from occlusion of the upper extremity blood supply. Symptomatic presentation is quite rare and therefore remains underdiagnosed by physicians. Possible catastrophic clinical consequences necessitate prompt rectification of the underlying disease and risk factors. Read More

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http://dx.doi.org/10.7759/cureus.6842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053697PMC
February 2020

Midthoracic Punctate Midline Myelotomy for Treatment of Chronic, Intractable, Nonmalignant, Abdominal Visceral Pain: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Mar 13. Epub 2020 Mar 13.

Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky.

Punctate midline myelotomy (PMM) is a surgical procedure that damages the ascending fibers of the postsynaptic dorsal column (PSDC) pathway to interrupt visceral pain transmission.1-3 It can offer relief to patients with chronic visceral pain conditions that are refractory to other treatments. Here, we present a surgical video of midthoracic PMM in a patient with chronic, intractable, nonmalignant visceral abdominal pain that failed over a decade of medical treatment. Read More

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http://dx.doi.org/10.1093/ons/opaa034DOI Listing

Clinico-diagnostic features of neuralgic amyotrophy in childhood.

Neurol Sci 2020 Mar 5. Epub 2020 Mar 5.

Paediatric Neurology and Muscular Diseases Unit, "G. Gaslini" Institute, Genoa, Italy.

Neuralgic amyotrophy (NA), even known as Personage-Turner's syndrome (PTS), is a neurologic condition, affecting the lower motor neurons of brachial plexus and/or individual nerves or nerve branches, characterized by pain, muscle weakness/atrophy, and sensory symptoms. NA has an acute/subacute onset, after an infection or vaccination; it is more common in male and is rare in the pediatric population. The etiology remains uncertain, being considered heterogeneous and multifactorial. Read More

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http://dx.doi.org/10.1007/s10072-020-04314-8DOI Listing

An Overlapping Case of Miller Fisher Syndrome and the Pharyngeal-Cervical-Brachial Variant of Guillain-Barré Syndrome.

Eur J Case Rep Intern Med 2020 27;7(2):001387. Epub 2020 Jan 27.

Hospital da Senhora da Oliveira, Guimarães, Portugal.

A 55-year-old Caucasian male presented initially to the emergency room (ER) reporting myalgia, chills and fever. Physical examination and laboratory tests were unremarkable and he was discharged with symptomatic care. He returned to our ER 2 weeks later reporting dizziness, loss of balance, blurred vision, mild dysarthria and bilateral hand paraesthesia. Read More

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http://dx.doi.org/10.12890/2020_001387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050976PMC
January 2020

Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders.

Brain 2020 Jun;143(6):1632-1650

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-onset dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy of neuroimaging in the early disease stages and the absence of molecular biomarkers, and therefore relies predominantly on clinical assessment. BvFTD shows significant symptomatic overlap with non-degenerative primary psychiatric disorders including major depressive disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders and even personality disorders. Read More

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http://dx.doi.org/10.1093/brain/awaa018DOI Listing
June 2020
9.196 Impact Factor

Rapid cognitive decline in a patient with chronic lymphocytic leukaemia: a case report.

J Med Case Rep 2020 Mar 3;14(1):39. Epub 2020 Mar 3.

The Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK.

Background: The use of monoclonal antibodies in various settings has been linked to the development of progressive multifocal leukoencephalopathy (PML). Whilst this association is well-described with agents such as rituximab and natalizumab, the literature describing the occurrence of PML with ofatumumab therapy (especially in a haematology setting) is sparse. This case aims to draw attention to the above association with a particular focus on the mechanisms by which B-cell-depleting therapy can precipitate PML during the treatment of haematological malignancy. Read More

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http://dx.doi.org/10.1186/s13256-020-2360-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055117PMC

Hidden disseminated extracutaneous AIDS-related Kaposi sarcoma.

IDCases 2020 10;19:e00716. Epub 2020 Feb 10.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

A 68-year-old man with past medical history of multiple cerebral infarctions presented to our hospital with subacute paresis. His vital signs on presentation were normal, and his physical examination, other than his neurological findings, was unremarkable. Neurological examinations suggested cerebellar ataxia. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030992PMC
February 2020

Correlation between Findings in Physical Examination, Magnetic Resonance Imaging, and Nerve Conduction Studies in Lumbosacral Radiculopathy Caused by Lumbar Intervertebral Disc Herniation.

Adv Orthop 2020 24;2020:9719813. Epub 2020 Jan 24.

Department of Orthopaedics Surgery and Traumatology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Purpose: The aim of this study was to find out the correlation between magnetic resonance imaging (MRI) and nerve conduction studies' (NCS) findings in patients with lumbosacral radiculopathy caused by lumbar intervertebral disc herniation. In addition, the study aimed at finding the correlation between the clinical manifestations of lumbosacral radiculopathy and both MRI and NCS. . Read More

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http://dx.doi.org/10.1155/2020/9719813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008266PMC
January 2020

Intradural Thoracic Arachnoid Cyst Fenestration for Spinal Cord Compression: A Case Illustration and Video Demonstration.

Cureus 2020 Jan 5;12(1):e6572. Epub 2020 Jan 5.

Neurosurgery, Mayo Clinic, Jacksonville, USA.

Spinal intradural arachnoid cysts are rare, benign intradural lesions of the spinal cord that can arise as a primary lesion or secondary due to inflammatory processes. Symptoms can range from an asymptomatic incidental finding to progressive myelopathy, with paresthesia and neuropathic pain. We present the case of an 80-year-old female with a longstanding history of back pain, urinary incontinence, difficulty ambulating and frequent falls, with rapid progression of her symptoms prior to presentation. Read More

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http://dx.doi.org/10.7759/cureus.6572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999717PMC
January 2020

Diagnosis and Treatment of Parkinson Disease: A Review.

JAMA 2020 02;323(6):548-560

Department of Neurology, University of Florida College of Medicine, Gainesville.

Importance: Parkinson disease is the most common form of parkinsonism, a group of neurological disorders with Parkinson disease-like movement problems such as rigidity, slowness, and tremor. More than 6 million individuals worldwide have Parkinson disease.

Observations: Diagnosis of Parkinson disease is based on history and examination. Read More

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http://dx.doi.org/10.1001/jama.2019.22360DOI Listing
February 2020

A longitudinal study of pupillary light reflex in 6- to 24-month children.

Sci Rep 2020 Jan 27;10(1):1205. Epub 2020 Jan 27.

Department of Biomedical, Biological & Chemical Engineering, University of Missouri, Columbia, MO, 65211, USA.

Pupillary light reflex (PLR) is an involuntary response where the pupil size changes with luminance. Studies have shown that PLR response was altered in children with autism spectrum disorders (ASDs) and other neurological disorders. However, PLR in infants and toddlers is still understudied. Read More

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http://dx.doi.org/10.1038/s41598-020-58254-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985190PMC
January 2020

Factors associated with cervical arterial dysfunction: a survey of physical therapist educators in the United States.

J Man Manip Ther 2020 Jan 24:1-7. Epub 2020 Jan 24.

Doctor of Physical Therapy Program, Duke University, Durham, NC, USA.

: The purpose of this study was to identify the key constructs associated with symptom description and behavior, natural history of complaints, and previous medical history of cervical arterial dysfunction (CAD) according to a panel of physical therapist (PT) educators.: An electronic survey was conducted of licensed PT educators currently involved in musculoskeletal physical therapy education within a credentialed program. Survey prompts queried educators to list the subjective and objective items associated with CAD, in open-text format. Read More

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http://dx.doi.org/10.1080/10669817.2020.1719300DOI Listing
January 2020

Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1.

Gynecol Oncol 2020 03 15;156(3):647-653. Epub 2020 Jan 15.

Office of the Clinical Director, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Objective: Germline pathogenic variation in DICER1 underlies a tumor-predisposition disorder with increased risk for cervical embryonal rhabdomyosarcoma and ovarian sex-cord stromal tumors, particularly Sertoli-Leydig cell tumors. The gynecologic and reproductive health of these females has not yet been described.

Methods: All female subjects recruited from November 2011 to July 2018 participating in an epidemiologic study of families with pathogenic DICER1 germline variation were included in this cross-sectional analysis. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.12.037DOI Listing

Automated Process Incorporating Machine Learning Segmentation and Correlation of Oral Diseases with Systemic Health.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:3387-3393

Imaging fluorescent disease biomarkers in tissues and skin is a non-invasive method to screen for health conditions. We report an automated process that combines intraoral fluorescent porphyrin biomarker imaging, clinical examinations and machine learning for correlation of systemic health conditions with periodontal disease. 1215 intraoral fluorescent images, from 284 consenting adults aged 18-90, were analyzed using a machine learning classifier that can segment periodontal inflammation. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857965DOI Listing

The Risk of Peripheral Nerve Tumor Biopsy in Suspected Benign Etiologies.

Neurosurgery 2020 03;86(3):E326-E332

Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida.

Background: Peripheral nerve sheath tumors (PNSTs) are tumors with unique clinical and imaging features that present to a variety of physicians. These lesions are often referred for biopsy, which can put nerve fascicles at risk. Preoperative biopsy may cause distortion of normal anatomic planes, making definitive resection difficult. Read More

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http://dx.doi.org/10.1093/neuros/nyz549DOI Listing

The effects of dual-task cognitive interference on gait and turning in Huntington's disease.

PLoS One 2020 7;15(1):e0226827. Epub 2020 Jan 7.

Department of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL, United States of America.

Huntington's disease (HD) is characterized by motor, cognitive, and psychiatric dysfunction. HD progression causes loss of automaticity, such that previously automatic tasks require greater attentional resources. Dual-task (DT) paradigms and fast-paced gait may stress the locomotor system, revealing deficits not seen under single-task (ST). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226827PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946131PMC

Acute headache management in emergency department. A narrative review.

Intern Emerg Med 2020 01 1;15(1):109-117. Epub 2020 Jan 1.

Department of Clinical and Molecular Medicine, Sapienza University, Via di Grottarossa, 1035, 00189, Rome, Italy.

Headache is a significant reason for access to Emergency Departments (ED) worldwide. Though primary forms represent the vast majority, the life-threatening potential of secondary forms, such as subarachnoid hemorrage or meningitis, makes it imperative for the ED physician to rule out secondary headaches as first step, based on clinical history, careful physical (especially neurological) examination and, if appropriate, hematochemical analyses, neuroimaging or lumbar puncture. Once secondary forms are excluded, distinction among primary forms should be performed, based on the international headache classification criteria. Read More

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http://dx.doi.org/10.1007/s11739-019-02266-2DOI Listing
January 2020

Clinical instrument to retrospectively capture levels of EDSS.

Mult Scler Relat Disord 2019 Dec 3;39:101884. Epub 2019 Dec 3.

Department of Neurology, Washington University in St. Louis; St. Louis, MO, USA. Electronic address:

Background: The Expanded Disability Status Scale (EDSS), a common outcome measure in Multiple Sclerosis (MS), is obtained prospectively through a direct standardized evaluation. The objective of this study is to develop and validate an algorithm to derive EDSS scores from previous neurological clinical documentation.

Methods: The algorithm utilizes data from the history, review of systems, and physical exam. Read More

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http://dx.doi.org/10.1016/j.msard.2019.101884DOI Listing
December 2019

Reliability and Diagnostic Accuracy of a New Vaginal Dynamometer to Measure Pelvic Floor Muscle Strength.

Female Pelvic Med Reconstr Surg 2020 Jan 25. Epub 2020 Jan 25.

Clinical Research Unit, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Barcelona, Spain.

Aims: Assess the intrarater and interrater reliabilities and diagnostic accuracy of a new vaginal dynamometer to measure pelvic floor muscle (PFM) strength in incontinent and continent women.

Methods: A test-retest reliability study including 152 female patients.

Exclusion Criteria: history of urge urinary incontinence, prolapse of pelvic organ, pregnancy, previous urogynecological surgery, severe vaginal atrophy, or neurological conditions. Read More

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http://dx.doi.org/10.1097/SPV.0000000000000796DOI Listing
January 2020

The Prevalence of Physiological Anisocoria and its Clinical Significance - A Neurosurgical Perspective.

Neurol India 2019 Nov-Dec;67(6):1500-1503

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Aim: We aimed to estimate the prevalence of physiological anisocoria and also evaluate the accuracy of clinical assessment of anisocoria employed in routine bedside examination.

Materials And Methods: A total of 708 voluntary subjects between the ages of 20-69 years who had no history of ophthalmologic or neurological disease other than refractive error were included in the study. In a closed room with uniform ambient lighting, the subjects' pupils were examined clinically and the presence or absence of anisocoria was recorded. Read More

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http://dx.doi.org/10.4103/0028-3886.273623DOI Listing

The Role of MRI in Children With Congenital Limb Deficiencies With Associated Scoliosis.

J Pediatr Orthop 2020 May/Jun;40(5):e390-e393

Shriners Hospitals for Children Greenville, Greenville, SC.

Background: The association of scoliosis and congenital limb deficiency has been well described. However, the incidence of neural axis abnormalities in this population is not known. The ability to assess the neural axis by physical examination may be limited in patients with a limb deficiency. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001484DOI Listing
December 2019

Primary HIV infection presenting with Kaposi sarcoma and limbic encephalitis.

J Neurovirol 2020 Apr 25;26(2):292-296. Epub 2019 Nov 25.

Department of Neurology, Saarland University Medical School, Homburg (Saar), Germany.

The development of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is often associated with neoplasia or infectious diseases as antibodies against neurons or synaptic proteins surface. A 30-year-old male patient was admitted to our department because of neurocognitive symptoms, particularly memory difficulties which had appeared a year prior and since then had been increasing. He had a medical history of smoking and hypertension. Read More

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http://dx.doi.org/10.1007/s13365-019-00815-1DOI Listing

Neurologic examination in the elderly.

Handb Clin Neurol 2019 ;167:73-88

Department of Neurology and Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, United States.

Clinical evaluation of neurologic disorders in the elderly requires seeking a thorough history and performing an age-appropriate neurologic examination with special attention to changes that occur with normal aging. The history should be obtained from the patient as well as collateral sources close to the patient to ensure accuracy and should include contextual elements such as medical history, social, economic, and psychological background, as well as an assessment of current functional state beyond activities of daily living. The safety of the patient, including the presence of physical, psychological, and financial threats, should be addressed during the interview. Read More

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http://dx.doi.org/10.1016/B978-0-12-804766-8.00005-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201860PMC

Midline Suboccipital Subtonsillar Approach with C1 Laminectomy for Resection of Foramen Magnum Meningioma: 2-Dimensional Operative Video.

J Neurol Surg B Skull Base 2019 Dec 28;80(Suppl 4):S365-S367. Epub 2019 Oct 28.

Department of Neurological Surgery, Eberhard-Karls-University, University Hospital, Tübingen, Germany.

We present a case of a medium-sized foramen magnum meningioma that was resected through a midline suboccipital subtonsillar approach with C1 laminectomy in prone (Concorde) position. The patient is a 77-year-old woman with a 6-month history of intermittent vertigo, moderate gait instability, and slight decline of memory. On magnetic resonance imaging (MRI) an extra-axial intradural lesion was discovered that originated from the right epicondylar region just inferior to the jugular tubercle and occupied the anterolateral aspect of the foramen magnum. Read More

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http://dx.doi.org/10.1055/s-0039-1698823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864396PMC
December 2019

[Investigation of the risk factors for the transition of episodic migraines to chronic migraines].

Agri 2019 Nov;31(4):172-177

Division of Headache, Department of Neurology, Health Sciences University, Istanbul Training and Research Hospital, Istanbul, Turkey.

Objectives: Chronic migraine (CM) is a frequent complication of migraines that has a serious impact on personal and social life and is still underdiagnosed. The aim of this study was to determine risk factors for the progression to CM and to investigate the relationship of these factors to the disease prognosis.

Methods: In all, 115 CM and 377 episodic migraine patients from between February 2015 and December 2017 were enrolled. Read More

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http://dx.doi.org/10.14744/agri.2019.65037DOI Listing
November 2019