2,324 results match your criteria Neurological History and Physical Examination


58 Case Report: Clinical Challenges in the Diagnoses and Management of Delirious Mania in a US Veteran with a Mental Health History of Bipolar Disorder.

CNS Spectr 2019 Feb;24(1):205-206

3Medical Director Inpatient Mental Health Services,Psychiatry, Department of Veteran Affairs Washington,DC.

A 46 year old Caucasian male veteran with a mental health history of Bipolar Disorder was admitted to the inpatient psychiatric unit following an episode of mania. He was re-started on his outpatient medication regimen for mood stabilization with Quetiapine, Lamotrigine, and Clonazepam. He improved initially, however, on hospital Day 3, the veteran was noted to have acute worsening of manic and psychotic symptoms including, decreased need for sleep, excess energy and responding to internal stimuli. Read More

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http://dx.doi.org/10.1017/S1092852919000452DOI Listing
February 2019

36 Too Scared to Blink: Pseudoparkinsonism due to Nyctophobia.

CNS Spectr 2019 Feb;24(1):194-195

2Medical Director,Smell and Taste Treatment and Research Foundation,Chicago,IL.

IntroductionA hallmark of Parkinson's disease is facial akinesia with decrease in blink frequency (Karson, 1984). A markedly decreased blink frequency from nyctophobia, a fear of the dark, has not heretofore been reported. METHOD: Case Study: A 26-year-old right handed male presented with a 20-year history of phantasmagoria. Read More

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http://dx.doi.org/10.1017/S1092852919000300DOI Listing
February 2019
1 Read

Musculoskeletal manifestations in end-stage renal disease patients on hemodialysis and relation to parathyroid dysfunction.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):68-82

Department of Internal Medicine, Nephrology Unit, Zagazig University, Zagazig, Egypt.

End-stage renal disease (ESRD) is associated with chronic kidney disease-mineral and bone disorder (CKD-MBD); including renal osteodystrophy, and biochemical changes reflecting mineral and hormonal abnormalities. CKD-MBD can lead to serious musculoskeletal manifestations with an impact on the functional status of patients. The objective is to find the frequency of the musculoskeletal manifestations in dialysis patients, to determine the impact on the functional ability of patients, and to detect the relation between parathyroid hormone (PTH) level and musculoskeletal manifestations. Read More

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February 2019

Gouty spondylodiscitis with lumbar vertebral body retrolisthesis: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14415

Orthopaedics Surgery Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.

Rationale: Gout occurs mainly in joints, but rarely in the spine. In the spine, urate crystals can cause intervertebral space instability but rarely lead to retrolisthesis. Here, we present an extremely rare disease with gout invaded the intervertebral disc with lumbar retrolisthesis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014415DOI Listing
February 2019
4 Reads

Stroke Mimic Caused by Acetazolamide.

Eur J Case Rep Intern Med 2018 25;5(5):000822. Epub 2018 May 25.

Department of Medicine, Unidade Local de Saude do Alto Minho, Hospital Conde de Bertiandos, Ponte do Lima, Portugal.

Objectives: To describe a case of a stroke mimic caused by iatrogenic ataxia due to acetazolamide.

Case Description: An 86-year-old man with a history of gout and glaucoma, presented to the emergency department with progressive confusion, dizziness, disequilibrium and slurred speech, 3 days after he had started acetazolamide following ocular surgery. Physical examination showed he was hypertensive and had dysarthria; it was not possible to observe his gait due to pain in the right foot presumed to be due to a gout crisis. Read More

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http://dx.doi.org/10.12890/2018_000822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346928PMC
May 2018
1 Read

Comparison of the history and physical examination for hip osteoarthritis and lumbar spinal stenosis.

Spine J 2019 Jan 29. Epub 2019 Jan 29.

Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.

Background: Leg pain associated with walking is sometimes incorrectly attributed to hip osteoarthritis (OA) or lumbar spinal stenosis (LSS).

Purpose: This study compared physicians' values of signs and symptoms for diagnosing and differentiating hip OA and LSS to their clinical utility.

Study Design/setting: Musculoskeletal physicians were surveyed with online questionnaires. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.01.006DOI Listing
January 2019
2.426 Impact Factor

Lorazepam-Assisted Interview in a Resistant Case of Functional Dysphonia.

J Voice 2019 Jan 28. Epub 2019 Jan 28.

Department of Psychiatry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Background: Functional neurological symptom disorder presents with varied neurological signs often as a result of stress. It is usually treated with supportive psychotherapy and occasionally antidepressants. Literature regarding treatment for resistant cases is scarce. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.01.002DOI Listing
January 2019
2 Reads

Atypical teratoid rhabdoid tumor mimicking type II neurofibromatosis: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14308

Department of Neurological Surgery, Children's Hospital, Zhejiang University School of Medicine, China.

Rationale: Brain magnetic resonance imaging (MRI) images of atypical teratoid rhabdoid tumor (ATRT) often present heterogeneous signals of various cells without remarkable features of the disease. We describe a unique case of atypical brain MRI images presenting as an type II neurofibromatosis and explore some diagnostic hints.

Patient Concerns: A 1-year-and-7-month-old boy admitted to our department with a 7-day history of drowsiness and 2-day history of emesis, and his presenting complaint was repeated vomit. Read More

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http://dx.doi.org/10.1097/MD.0000000000014308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380747PMC
February 2019
1 Read

Challenges in diagnosis of spinal epidural abscess: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14196

Department of Orthopedics.

Rationale: Spinal epidural abscess (SEA) is a rare condition that shows a high prevalence in immunocompromised patients. The clinical presentation of SEA includes the "classic triad" of pain, fever, and neurological dysfunction. However, these nonspecific features can lead to a high rate of misdiagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380696PMC
February 2019
1 Read

Epilepsy in Children with Autistic Spectrum Disorder.

Children (Basel) 2019 Jan 25;6(2). Epub 2019 Jan 25.

Department of Pediatrics and Medical Genetics, Medical University-Plovdiv,4000, Bulgaria.

The comorbidity of autistic spectrum disorder (ASD) and epilepsy has been widely discussed but many questions still remain unanswered. The aim of this study was to establish the occurrence of epilepsy among children with ASD to define the type of epileptic seizures and syndromes, the age of onset of epilepsy, EEG abnormalities, the used antiepileptic drugs and the therapeutic responses for seizures and autistic behavior, as well as to find some correlations between epilepsy and gender, etiology and intellectual disability (ID). A retrospective study of medical files of 59 patients (aged 1⁻18 years) with ASD during a 5-year period was performed. Read More

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http://dx.doi.org/10.3390/children6020015DOI Listing
January 2019
1 Read

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial.

JAMA 2019 02;321(6):553-561

National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Importance: There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.

Objective: To evaluate the effect of intensive blood pressure control on risk of dementia.

Design, Setting, And Participants: Randomized clinical trial conducted at 102 sites in the United States and Puerto Rico among adults aged 50 years or older with hypertension but without diabetes or history of stroke. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.21442DOI Listing
February 2019
38 Reads

Intraparenchymal schwannoma with calcification of the temporal lobe: Case report and literature review.

Medicine (Baltimore) 2019 Jan;98(4):e14263

Department of Neurosurgery.

Rationale: Intracranial schwannomas most frequently arise from the trigeminal nerve and the vestibular nerve. Schwannomas within the cerebral parenchyma are exceedingly rare. Additionally, calcification is an uncommon histopathological and radiological characteristic in schwannomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358367PMC
January 2019
7 Reads

CD5-Positive Intravascular Large B-Cell Lymphoma in a Patient with Wilson's Disease: Case Report and Review of the Literature.

Case Rep Pathol 2018 16;2018:5140586. Epub 2018 Dec 16.

Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 6 Ohio Drive, Suite 202, Lake Success, New York, 11042, USA.

Intravascular large B-cell lymphoma (IVLBCL) is a rare extra-nodal B-cell lymphoma that proliferates within small/intermediate blood vessels and capillaries while sparing large blood vessels and organ parenchyma. Clinical presentation is highly variable and may include B symptoms, neurological deficits, and/or cutaneous findings. The diagnosis of IVLBCL is difficult due to multiorgan involvement and nonspecific symptoms. Read More

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http://dx.doi.org/10.1155/2018/5140586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311313PMC
December 2018
7 Reads

When the factory shuts down.

Emerg Med J 2019 Jan;36(1):51-60

Department of Emergency Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.

Clinical Introduction: A 56-year-old man without known medical history was brought to our ED after he was found next to his bed, agitated and with waxing and waning consciousness. He has been bedbound for 5 days after a long-standing period of malnutrition. Physical examination reveals Kussmaul breathing, heart rate of 62/min and blood pressure of 135/100 mm Hg, normal cardiac, abdominal and a non-focal neurological examination other than confusion and altered level of consciousness. Read More

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http://dx.doi.org/10.1136/emermed-2018-207676DOI Listing
January 2019
2 Reads

Munchausen by proxy syndrome mimicking childhood-onset systemic lupus erythematosus.

Lupus 2019 Feb 7;28(2):249-252. Epub 2019 Jan 7.

1 Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory multisystem autoimmune disease that requires multiple differential diagnoses. Munchausen by proxy syndrome (MBPS) is a form of child abuse, where a caregiver intentionally creates a medical history and induces or fabricates signs or disease in a patient. To our knowledge, there is no case report of MBPS mimicking cSLE diagnosis. Read More

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http://dx.doi.org/10.1177/0961203318821156DOI Listing
February 2019
2 Reads

Foreign body in the thoracic spine due to a nail gun penetrating injury: A case report.

Medicine (Baltimore) 2018 Dec;97(52):e13870

Department of Emergency Medicine, Kaohsiung Medical University Hospital.

Rationale: Spinal cord injuries could be catastrophic because they may result in severe neurovascular complications. Here, we present a case of thoracic spine-penetrating injury by a nail-gun.

Patient Concerns: A 60-year-old male presented to our emergency department with complaints of progressive right chest pain for 1 week that was preceded by back pain. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0006
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http://dx.doi.org/10.1097/MD.0000000000013870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314768PMC
December 2018
5 Reads

Intracranial Hemorrhage in Children With Inherited Bleeding Disorders: A Single Center Study in China.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Intracranial hemorrhage (ICH) is a life-threatening condition in children. Inherited bleeding disorders (IBD) have high risk of ICH.

Aim: This single center study aims to identify the incidence, risk factors, and neurological outcome of ICH in children who suffer from IBD. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001358DOI Listing
December 2018
5 Reads

Atypical cerebral palsy: genomics analysis enables precision medicine.

Genet Med 2018 Dec 13. Epub 2018 Dec 13.

BC Children's Hospital Research Institute, Vancouver, BC, Canada.

Purpose: The presentation and etiology of cerebral palsy (CP) are heterogeneous. Diagnostic evaluation can be a prolonged and expensive process that might remain inconclusive. This study aimed to determine the diagnostic yield and impact on management of next-generation sequencing (NGS) in 50 individuals with atypical CP (ACP). Read More

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http://www.nature.com/articles/s41436-018-0376-y
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http://dx.doi.org/10.1038/s41436-018-0376-yDOI Listing
December 2018
21 Reads

Periodontal Ehlers-Danlos syndrome is associated with leukoencephalopathy.

Neurogenetics 2019 Mar 8;20(1):1-8. Epub 2018 Dec 8.

Department of Child Neurology and Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Here, we report brain white matter alterations in individuals clinically and genetically diagnosed with periodontal Ehlers-Danlos syndrome, a rare disease characterized by premature loss of teeth and connective tissue abnormalities. Eight individuals of two families clinically diagnosed with periodontal Ehlers-Danlos syndrome were included in the present study and underwent general physical, dental, and neurological examination. Whole exome sequencing was performed, and all patients included in the study underwent MRI of the brain. Read More

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http://link.springer.com/10.1007/s10048-018-0560-x
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http://dx.doi.org/10.1007/s10048-018-0560-xDOI Listing
March 2019
18 Reads

Caroli's-type ductal plate malformation and a portosystemic shunt in a 4-month-old kitten.

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918812329. Epub 2018 Nov 20.

Small Animal Specialist Hospital, Sydney, Australia.

Case Summary: A 4-month-old neutered male Russian Blue kitten had a 4 week history of hypersalivation and failure to thrive. In addition, there was a 2 week history of soft tissue swelling on the ventral abdomen, which had failed to improve with antimicrobial therapy. There were no significant physical examination or neurological deficits on examination; however, the cat had a quiet demeanour for its age. Read More

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http://dx.doi.org/10.1177/2055116918812329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247498PMC
November 2018
1 Read

Positive clinical signs in neurological diseases - An observational study.

J Clin Neurosci 2019 Jan 19;59:141-145. Epub 2018 Nov 19.

Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Many patients with organic neurological disease have symptoms and signs that are unexplained by their disease condition. We attempted to explore the prevalence of positive clinical signs in patients with various organic neurological diseases. We performed a prospective uncontrolled observational study on the presence of 7 positive signs in adults with various organic neurological diseases that were admitted to our tertiary care hospital. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.10.113DOI Listing
January 2019
10 Reads

Structural signature in SCA1: clinical correlates, determinants and natural history.

J Neurol 2018 Dec 15;265(12):2949-2959. Epub 2018 Oct 15.

Department of Neurology, University of Campinas (UNICAMP), R. Tessália Vieira de Camargo, 126, Campinas, 13083-887, Brazil.

Spinocerebellar ataxia type 1 is an autosomal dominant disorder caused by a CAG repeat expansion in ATXN1, characterized by progressive cerebellar and extracerebellar symptoms. MRI-based studies in SCA1 focused in the cerebellum and connections, but there are few data about supratentorial/spinal damage and its clinical relevance. We have thus designed this multimodal MRI study to uncover the structural signature of SCA1. Read More

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http://dx.doi.org/10.1007/s00415-018-9087-1DOI Listing
December 2018
10 Reads

Hypertensive Crisis with Neurological Impairment Mimicking a Guillain-Barrè Syndrome: Searching for a Link.

High Blood Press Cardiovasc Prev 2018 Dec 8;25(4):421-424. Epub 2018 Oct 8.

Studium Patavium (Formerly Department of Medicine), University of Padova, Padua, Italy.

Guillain-Barré syndrome (GBS) may be complicated by severe hypertension (HT) and in turns severe HT can occur with neurological damage mimicking a GBS, so that underlying causes should be investigated. We describe a case of a 62-year-old woman presented to the emergency department for hypertensive crisis with symmetric flaccid paralysis, hypotonia and hyporeflexia of both upper and lower limbs. Brain computed tomography, magnetic resonance imaging and lumbar puncture were normal. Read More

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http://dx.doi.org/10.1007/s40292-018-0283-yDOI Listing
December 2018
3 Reads

Neonatal hypotonia: is it a diagnostic challenge?

Rev Neurol 2018 Oct;67(8):287-292

Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal.

Introduction: Hypotonia is a frequent sign of disease in newborns. However, it's a nonspecific clinical finding: may be the presentation form of a systemic or neurological disease.

Aims: To study the main causes of neonatal hypotonia as well as to evaluate the diagnostic accuracy of the anamnesis and physical examination of the hypotonic newborn. Read More

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October 2018
19 Reads

Functional neurological disorders: acute presentations and management.

Clin Med (Lond) 2018 Oct;18(5):414-417

Institute of Molecular and Clinical Sciences, St George's University of London, London, UK

Functional neurological disorders (FND) are common and associated with significant morbidity and healthcare costs. Patients with FND often present acutely, particularly with dissociative seizures (resembling epilepsy) or persistent weakness resembling a stroke. History and careful observation and examination are critical to diagnosis, as investigations will often be normal or non-contributory. Read More

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http://www.clinmed.rcpjournal.org/lookup/doi/10.7861/clinmed
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http://dx.doi.org/10.7861/clinmedicine.18-5-414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334101PMC
October 2018
7 Reads

[Pollution and Chronic Arsenic Poisoning Associated with the Operation of Former Toroku Mine in Takachiho Town, Miyazaki Prefecture].

Authors:
Atsushi Ohtsubo

Nihon Eiseigaku Zasshi 2018 ;73(3):275-276

Environment and Forestry Department, Miyazaki Prefectural Government.

Japan has laws in place that are intended to reduce health risks from environmental pollution, including air pollution. On the basis of the "polluters pay" principle, these laws are designed to support pollution victims. In Miyazaki Prefecture, people were chronically exposed to arsenic in Takachiho Town as a result of the operation of Toroku Mine. Read More

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http://dx.doi.org/10.1265/jjh.73.275DOI Listing
October 2018
7 Reads

Neurosyphilis Presenting with Anxiety: A Case Report.

Cureus 2018 Jul 22;10(7):e3020. Epub 2018 Jul 22.

Surgery Student, West Virginia School of Osteopathic Medicine, Lewisburg , USA.

The number of cases of late and late latent syphilis in the United States is on the rise. This diagnosis is often forgotten when an elderly patient is being worked up for altered mental status. Rarely does a 70-year-old male with neurosyphilis present simply with anxiety. Read More

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http://dx.doi.org/10.7759/cureus.3020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150767PMC
July 2018
19 Reads

The approach of physiatrists to low back pain across Europe.

J Back Musculoskelet Rehabil 2019 ;32(1):131-139

Department of Rehabilitation Medicine, General Teaching Hospital Prague, Prague, Czech Republic.

Background: Low back pain (LBP) is the most common type of musculoskeletal pain, thus it is one of the most commonly encountered conditions in Physical and Rehabilitation Medicine. The physicians who are primarily responsible for the nonsurgical management of LBP are physiatrists.

Objective: The present study aimed to investigate the approaches of physiatrists to low back pain across Europe. Read More

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http://dx.doi.org/10.3233/BMR-171001DOI Listing
January 2019
13 Reads

Chronic intestinal pseudo-obstruction due to al amyloidosis: a case report and literature review.

Clin J Gastroenterol 2018 Sep 19. Epub 2018 Sep 19.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Minami 1-Jo Nishi 16-Chome, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.

A 59-year-old woman presented to our hospital with a 6-month history of nausea, weight loss, and abdominal distension. Physical examination revealed abdominal distension without tenderness, and edema, numbness, and multiple peripheral neuropathy in the limbs. Blood test results showed anemia, hypoproteinemia, and hypoalbuminemia. Read More

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http://dx.doi.org/10.1007/s12328-018-0909-6DOI Listing
September 2018
7 Reads

[Possibilities of diagnostics in unilateral fibular-nerve-paresis in a calf].

Schweiz Arch Tierheilkd 2018 09;160(9):539-545

Klinik für Wiederkäuer mit Ambulanz und Bestandsbetreuung, Ludwig-Maximilians-Universität München.

Introduction: The present case report describes the workup of unilateral fibular-nerve-paresis in a female neonatal Fleckvieh calf. The calf was admitted to the Clinic for Ruminants with Ambulatory and Herd Health Services, Ludwig- Maximilians-University Munich as part of an investigation into a herd problem. The herd problem was presented as movement disorder in neonatal calves with an incidence of 10%. Read More

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http://sat.gstsvs.ch/de/pubmed/?doi=10.17236/sat00175
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http://dx.doi.org/10.17236/sat00175DOI Listing
September 2018
7 Reads

Intellectual Disability and Psychotropic Medications.

J Dev Behav Pediatr 2018 Sep;39(7):591-593

Division of Developmental Behavioral Pediatrics, University of Michigan Medical School, Ann Arbor, MI.

Case: Andrew is a 17-year-old male with trisomy 21, commonly known as Down syndrome, and accompanying severe intellectual disability who presents to your primary care office with his father for the first time to establish care and assistance with transition. Andrew has a history of a complete atrioventricular canal that was repaired as an infant and poorly controlled infantile spasms. Currently, he struggles with constipation, esophageal strictures, medullary nephrocalcinosis, urinary retention, sleep dysregulation, G-tube dependency, and hip dysplasia. Read More

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http://Insights.ovid.com/crossref?an=00004703-900000000-9926
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http://dx.doi.org/10.1097/DBP.0000000000000613DOI Listing
September 2018
26 Reads

Ultrasound Measures of Brain Pulsatility Correlate with Subcortical Brain Volumes in Healthy Young Adults.

Ultrasound Med Biol 2018 11 18;44(11):2307-2313. Epub 2018 Aug 18.

CHRU de Tours, Pôle de Psychiatrie, Tours, France; UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Increasing evidence suggests that brain pulsatility is involved in the pathophysiology of various neurological and psychiatric disorders. However, it remains unclear whether high brain pulsatility is damaging to or protective of the brain in normal conditions, and this could depend on the age of the individual and the methods used to measure brain pulsatility. The goal of our study was to investigate associations between subcortical volumes and brain pulsatility as assessed with ultrasound in healthy young adults using both a conventional method (transcranial Doppler pulsatility index [TCD-PI]) and the innovative method of tissue pulsatility imaging (TPI), which allows a high level of detection of small brain movements (micrometers). Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.06.016DOI Listing
November 2018
4 Reads

Wearables for gait and balance assessment in the neurological ward - study design and first results of a prospective cross-sectional feasibility study with 384 inpatients.

BMC Neurol 2018 Aug 16;18(1):114. Epub 2018 Aug 16.

Department of Neurology and Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University Tübingen, 72076, Tübingen, Germany.

Background: Deficits in gait and balance are common among neurological inpatients. Currently, assessment of these patients is mainly subjective. New assessment options using wearables may provide complementary and more objective information. Read More

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http://dx.doi.org/10.1186/s12883-018-1111-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094895PMC
August 2018
5 Reads

Survival patterns and cancer determinants in families with myotonic dystrophy type 1.

Eur J Neurol 2019 Jan 16;26(1):58-65. Epub 2018 Sep 16.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Background And Purpose: Research indicates that patients with myotonic dystrophy type 1 (DM1) are at increased risk of cancer and early death. Family data may provide insights given DM1 phenotypic heterogeneity, the broad range of non-muscular manifestations and the usual delays in the diagnosis of DM1.

Method: Family history data were collected from 397 genetically and/or clinically confirmed DM1 patients (respondents) enrolled in the US or UK myotonic dystrophy registries. Read More

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http://doi.wiley.com/10.1111/ene.13763
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http://dx.doi.org/10.1111/ene.13763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283697PMC
January 2019
17 Reads

Infection, Immunodeficiency, and Inflammatory Diseases in Autoimmune Neurology.

Semin Neurol 2018 Jun 16;38(3):379-391. Epub 2018 Jul 16.

Department of Neurology, University of Utah, Salt Lake City, Utah.

When patients present with neurological syndromes, such as encephalopathy/encephalitis, meningitis, and/or myelopathy/myelitis, the differential diagnosis is often broad, including infectious, inflammatory, autoimmune, vascular, and neoplastic etiologies. Just with inflammatory and autoimmune etiologies alone, there are numerous causative diseases. A comprehensive history and physical examination investigating for extraneurologic manifestations of immune-mediated disease is often necessary. Read More

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http://dx.doi.org/10.1055/s-0038-1660820DOI Listing
June 2018
5 Reads

Sub-classifying patients with mild traumatic brain injury: A clustering approach based on baseline clinical characteristics and 90-day and 180-day outcomes.

PLoS One 2018 11;13(7):e0198741. Epub 2018 Jul 11.

School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, United States of America.

Background: The current classification of traumatic brain injury (TBI) into "mild", "moderate", or "severe" does not adequately account for the patient heterogeneity that still exists within each of these categories. The objective of this study was to identify "sub-groups" of mild TBI (mTBI) patients based on data available at the time of the initial post-TBI patient evaluation and to determine if the sub-grouping correlates with patient outcomes at 90 and 180 days post-TBI.

Methods: Data from patients in the TRACK-TBI Pilot dataset who had a Glasgow Coma Scale (GCS) score of 13 to 15 at arrival to the Emergency Department and a closed head injury were included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198741PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040703PMC
December 2018
28 Reads

Minimally Invasive Microsurgical Resection of Primary, Intradural Spinal Tumors is Feasible and Safe: A Consecutive Series of 83 Patients.

Neurosurgery 2018 Mar;82(3):365-371

Faculty of Medicine, University of Oslo, Oslo, Norway.

Background: To date, the traditional approach to intraspinal tumors has been open laminectomy or laminoplasty followed by microsurgical tumor resection. Recently, however, minimally invasive approaches have been attempted by some.

Objective: To investigate the feasibility and safety of minimally invasive surgery (MIS) for primary intradural spinal tumors. Read More

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http://dx.doi.org/10.1093/neuros/nyx253DOI Listing
March 2018
4 Reads

Occipital Headaches and Neuroimaging in Children.

Curr Pain Headache Rep 2018 Jul 10;22(9):59. Epub 2018 Jul 10.

The University of California, San Francisco (UCSF), Department of Neurology, Pediatric Brain Center, Child & Adolescent Headache Program, Mission Hall, Box 0137, 550 16th Street, 4th Floor, San Francisco, California, 94158, USA.

Purpose Of Review: The goal of this review is to outline the prevalence and significance of occipital headaches in children and how they relate to neuroimaging findings. We seek to evaluate the concern that occipital headaches in children are indicative of secondary headache pathology by reviewing the yield of neuroimaging in pediatric patients with occipital headache location.

Recent Findings: Occipital headaches are a common presentation of primary headache disorders in children, seen in 7-16% of children presenting for evaluation of headache and in up to 20% of children diagnosed with migraine in the emergency department. Read More

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http://link.springer.com/10.1007/s11916-018-0712-6
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http://dx.doi.org/10.1007/s11916-018-0712-6DOI Listing
July 2018
31 Reads

Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview.

Eur Spine J 2018 Nov 3;27(11):2791-2803. Epub 2018 Jul 3.

Department of General Practice, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Objective: The aim of this study was to provide an overview of the recommendations regarding the diagnosis and treatment contained in current clinical practice guidelines for patients with non-specific low back pain in primary care. We also aimed to examine how recommendations have changed since our last overview in 2010.

Method: The searches for clinical practice guidelines were performed for the period from 2008 to 2017 in electronic databases. Read More

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http://dx.doi.org/10.1007/s00586-018-5673-2DOI Listing
November 2018
18 Reads

Benign paroxysmal torticollis of infancy does not lead to neurological sequelae.

Dev Med Child Neurol 2018 12 28;60(12):1251-1255. Epub 2018 Jun 28.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Aim: To elucidate the natural course of benign paroxysmal torticollis, the relationship of this disorder to migraine and other paroxysmal diseases, and to analyse candidate genes.

Method: This was a case series of children with benign paroxysmal torticollis of infancy (BPTI) diagnosed from 1998 to 2005, at Astrid Lindgren Children's Hospital, Stockholm, Sweden. A neurological examination and a formalized motor assessment were performed from 2005 to 2007. Read More

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http://dx.doi.org/10.1111/dmcn.13939DOI Listing
December 2018
18 Reads

Early urological care of patients with spinal cord injury.

World J Urol 2018 Oct 9;36(10):1537-1544. Epub 2018 Jun 9.

Neuro-Urology, Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

Purpose: After spinal cord injury (SCI), the initial goals of urological management include maintaining safe storage of urine with efficient bladder emptying, maximising urinary continence, and minimising the risk of urological complications.

Methods: This review was performed according to the methodology recommended by the Joint SIU-ICUD International Consultation. Embase and Medline databases were used to identify literature relevant to the early urological care of SCI patients. Read More

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http://link.springer.com/10.1007/s00345-018-2367-7
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http://dx.doi.org/10.1007/s00345-018-2367-7DOI Listing
October 2018
29 Reads

Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography.

JAMA Neurol 2018 Oct;75(10):1198-1205

National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust NHS Foundation Trust and UCL Institute of Ophthalmology, London, England.

Importance: Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia.

Objective: To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people.

Design, Setting, And Participants: UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 years at enrollment who underwent baseline retinal optical coherence tomography imaging, a physical examination, and a questionnaire. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.1578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233846PMC
October 2018
1 Read

Could an increase in vigilance for spinal tuberculosis at primary health care level, enable earlier diagnosis at district level in a tuberculosis endemic country?

Afr J Prim Health Care Fam Med 2018 Jun 18;10(1):e1-e9. Epub 2018 Jun 18.

Private Practice,Centani.

Background: Expert clinicians and researchers in the field of spinal tuberculosis (STB) advocate for early identification and diagnosis as a key to reducing disability, severity of disease, expensive surgery and death, especially in tuberculosis (TB) endemic countries like South Africa. South Africa has the highest incidence per capita of tuberculosis in the world, and a conservative estimate of the incidence of STB in South Africa is 8-16:100 000. People living with STB may initially present to primary health care (PHC) centres, where the opportunity exists for early identification. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018652PMC
http://dx.doi.org/10.4102/phcfm.v10i1.1666DOI Listing
June 2018
17 Reads

Ulcerative colitis with Guillain-Barré syndrome: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11013

Department of Gastroenterology.

Rationale: Ulcerative colitis is a chronic and recurrent inflammatory disease involving the intestine. It is reported that about 40% of patients with ulcerative colitis have extraintestinal manifestations, where as the literature on neurological involvement as extraintestinal manifestation is rather limited. Guillain-Barré syndrome is an abnormal immune-mediated and acute-acquired demyelinating disease that mainly affects the peripheral nervous system and often has a phenomenon of protein-cell separation of cerebrospinal fluid. Read More

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http://dx.doi.org/10.1097/MD.0000000000011013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024027PMC

[Evidence of sensory bladder inhibitor reflex].

Prog Urol 2018 Sep 11;28(10):502-508. Epub 2018 Jun 11.

UPMC Université Paris 06, GRC 01, GREEN, Group of clinical research in neuro-urology, Sorbonne Universités, 75005, Paris, France; Service de neuro-urologie, hôpital Tenon, AP-HP, 75020, Paris, France.

Introduction: Need to void level depends on two parameters, bladder volume and attentional process. If it is well known that the maximum voluntary contraction of the perineal muscles may transiently inhibit the micturition reflex itself, no work demonstrates the effect of this contraction on the intensity of the need itself.

Methods: An experimental, prospective, open, monocentric study was conducted between March and April 2017. Read More

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http://dx.doi.org/10.1016/j.purol.2018.05.004DOI Listing
September 2018
1 Read

Expanding spectrum of 2 gene disorders: Myoclonic epilepsy, mental retardation, spasticity, and extrapyramidal features.

Epilepsia Open 2018 Jun 23;3(2):270-275. Epub 2018 Mar 23.

Department of Neurology St. John's Medical College Hospital Bengaluru Karnataka India.

Pontocerebellar hypoplasia type 6 (PCH6) is an autosomal recessive mitochondrial disease, typically characterized by pontine atrophy, vermian hypoplasia, infantile encephalopathy, generalized hypotonia, and intractable seizures. The purpose of this study is to describe the seizures and other neurological manifestations of 2 gene mutations and to compare the clinical features with other causes of progressive myoclonic epilepsy. Detailed history, physical examination, and clinical and genetic work-up were performed in 2 siblings who presented with progressive myoclonic epilepsy. Read More

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http://dx.doi.org/10.1002/epi4.12108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983106PMC
June 2018
32 Reads

Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study.

Neurol Sci 2018 Aug 28;39(8):1345-1353. Epub 2018 May 28.

Pharmaceutical Sciences Research Center, and Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Phytotherapy is a source of finding new remedies for migraine. Traditional chamomile oil (chamomile extraction in sesame oil) is a formulation in Persian medicine (PM) for pain relief in migraine. An oleogel preparation of reformulated traditional chamomile oil was prepared and then standardized based on chamazulene (as a marker in essential oil) and apigenin via gas chromatography (GC) and high-performance liquid chromatography (HPLC) methods, respectively. Read More

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http://dx.doi.org/10.1007/s10072-018-3415-1DOI Listing
August 2018
6 Reads

Spinal tophaceous gout presenting in a young adult without pain.

BMJ Case Rep 2018 May 26;2018. Epub 2018 May 26.

Department of Internal Medicine, University at Buffalo Catholic Health, Buffalo, New York, USA.

A 26-year-old man with a medical history of gout and morbid obesity presented with a 7-day history of decreased sensation to light touch and temperature from the feet to the level of the nipples. He also noted incomplete voiding. Laboratory investigations showed an elevated serum uric acid level (10. Read More

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http://dx.doi.org/10.1136/bcr-2018-224406DOI Listing
May 2018
10 Reads

Diagnostic yield of neuroimaging in syncope patients without high-risk symptoms indicating neurological syncope.

Am J Emerg Med 2019 Feb 16;37(2):228-230. Epub 2018 May 16.

Department of Emergency Medicine, Tepecik Training and Research Hospital, Turkey.

Objectives: Diagnostic tests are widely used for patients with syncope in the emergency department (ED). This study aimed to determine the diagnostic yield of neuroimaging in patients with syncope without high-risk symptoms.

Methods: Adult patients who presented to the ED with syncope in 2016 were screened retrospectively. Read More

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http://dx.doi.org/10.1016/j.ajem.2018.05.033DOI Listing
February 2019
3 Reads