1,287 results match your criteria Neurologic Effects of Caffeine

Diagnosis and Management of Headache: A Review.

JAMA 2021 May;325(18):1874-1885

Department of Neurology, Weill Cornell Medical College, New York, New York.

Importance: Approximately 90% of people in the US experience headache during their lifetime. Migraine is the second leading cause of years lived with disability worldwide.

Observations: Primary headache disorders are defined as headaches that are unrelated to an underlying medical condition and are categorized into 4 groups: migraine, tension-type headache, trigeminal autonomic cephalalgias, and other primary headache disorders. Read More

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Post-operative pain management in dental implant surgery: a systematic review and meta-analysis of randomized clinical trials.

Clin Oral Investig 2021 May 10;25(5):2511-2536. Epub 2021 Apr 10.

Department of Oral and Maxillofacial Pathology, Radiology & Medicine, New York University College of Dentistry, New York, NY, USA.

Purpose: To evaluate the clinical efficacy of various analgesic medications in mitigating orofacial pain following dental implant surgery.

Materials And Methods: A systematic search was conducted to identify randomized controlled clinical trials (RCTs). The primary outcomes examined were post-operative pain (POP) and consumption of rescue analgesics following implant placement; secondary outcomes included adverse effects, post-operative inflammation, infection, swelling, bleeding, patient satisfaction, and quality of life. Read More

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Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.

Nat Commun 2021 04 9;12(1):2113. Epub 2021 Apr 9.

Sleep and Circadian Neuroscience Institute (SCNi), Department of Pharmacology, University of Oxford, Oxford, UK.

The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian timing system directly and independently of sleep physiology, but how caffeine mediates these effects upon the circadian clock is unclear. Here we identify an adenosine-based regulatory mechanism that allows sleep and circadian processes to interact for the optimisation of sleep/wake timing in mice. Read More

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Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science.

Br J Anaesth 2021 May 26;126(5):996-1008. Epub 2021 Feb 26.

Department of Anesthesiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. Electronic address:

Background: Novel preventive therapies are needed for postoperative delirium, which especially affects older patients. A mouse model is presented that captures inflammation-associated cortical slow wave activity (SWA) observed in patients, allowing exploration of the mechanistic role of prostaglandin-adenosine signalling.

Methods: EEG and cortical cytokine measurements (interleukin 6, monocyte chemoattractant protein-1) were obtained from adult and aged mice. Read More

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Caffeine-related effects on cognitive performance: Roles of apoptosis in rat hippocampus following sleep deprivation.

Biochem Biophys Res Commun 2021 01 17;534:632-638. Epub 2020 Nov 17.

Basic Medical Sciences College, Hubei University of Chinese Medicine, Wuhan, 430065, China. Electronic address:

Caffeine is a common stimulant widely existed in food and has stimulatory effects on the central nervous system, shift-work individuals often rely on caffeine to maintain attention and keep awake. Although sleep deprivation (SD) is widely considered as an independent risk factor for cognition retardations, however, little is well understood about the synergistic role of caffeine dosage and SD for cognitive performance. This research intended to investigate the underlying molecular mechanism of varying caffeine doses on cognitive function after sleep deprivation. Read More

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January 2021

Psychoactive drug and medication use among patients referred to a tertiary sleep laboratory population.

Psychiatry Res 2020 12 30;294:113545. Epub 2020 Oct 30.

Eastern Health Clinical School, Monash University, 5 Arnold Street, Box Hill 3128, VIC, Australia; Department of Respiratory and Sleep Medicine, Eastern Health, Melbourne, Australia.

Psychoactive drugs including alcohol, caffeine, and prescription medications are commonly consumed to alter sleep/wake states, however the prevalence and impact of these drugs among populations seeking assessment from sleep physicians are unknown. We investigated the prevalence of commonly used drugs (alcohol and caffeine), and medications in a population (N=120; 50 females and 70 males) attending a tertiary sleep clinic for diagnostic polysomnography (PSG) assessment. In addition to objective sleep assessment, participants completed questionnaires assessing sleep quality (Pittsburgh Sleep Quality Index, PSQI), daytime sleepiness (Epworth Sleepiness Scale, ESS), depression and anxiety (Hospital Anxiety and Depression Scale, HADS), alcohol use (Alcohol Use Disorders Identification Test, AUDIT), caffeine and medication use, as well as their experience of adverse events (motor vehicle accidents and near-miss crashes). Read More

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December 2020

Pregnancy Myths and Practical Tips.

Am Fam Physician 2020 10;102(7):420-426

Carl R. Darnall Army Medical Center Family Medicine Residency Program, Fort Hood, TX, USA.

For many patients, pregnancy is a highly anticipated and exciting phase of life, but it can also be anxiety provoking. Family physicians can resolve some of this anxiety and promote maternal and fetal health by making specific recommendations at prenatal visits. A daily prenatal vitamin with at least 400 mcg of folic acid and 30 mg of elemental iron should be recommended to promote neurologic and musculoskeletal fetal development. Read More

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October 2020

Fluid Intake and Urinary Symptoms in Patients with Multiple Sclerosis.

J Urol 2020 Dec 28;204(6):1284-1289. Epub 2020 Jul 28.

Department of Urology, Stony Brook University Hospital, Stony Brook, New York.

Purpose: The relationship between fluid intake and lower urinary tract symptoms in individuals with neurogenic bladder is unknown. We investigated the association between fluid intake and urinary symptoms in patients with multiple sclerosis.

Materials And Methods: A prospective cross-sectional study of patients with multiple sclerosis presenting to the neurology office was conducted. Read More

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December 2020

The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making.

Pharmacol Biochem Behav 2020 11 8;198:173035. Epub 2020 Sep 8.

Dept. Psychobiology, Universitat Jaume I, 12071 Castelló, Spain; Dept. Psychology, University of Connecticut, Storrs, CT 06269-1020, USA. Electronic address:

Considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function. Nonselective adenosine antagonists such as the methylxanthine caffeine as well as selective adenosine A antagonists have been shown to produce antiparkinsonian and antidepressant effects in animal models. The present studies were conducted to assess if another methylxantine, theophylline, can reverse motor and motivational impairments induced by dopamine antagonism in rats. Read More

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November 2020

Caffeine increases strength and power performance in resistance-trained females during early follicular phase.

Scand J Med Sci Sports 2020 Nov 26;30(11):2116-2129. Epub 2020 Aug 26.

Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.

The effects of 4 mg·kg caffeine ingestion on strength and power were investigated for the first time, in resistance-trained females during the early follicular phase utilizing a randomized, double-blind, placebo-controlled, crossover design. Fifteen females (29.8 ± 4. Read More

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November 2020

Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

Nutrients 2020 Jun 19;12(6). Epub 2020 Jun 19.

KGK Science Inc., London, ON N6A 5R8, Canada.

The lack of effective treatment for chronic discomfort without negative side effects highlights the need for alternative treatments. Pain Bloc-R is a natural health product composed of vitamins B, B, D, white willow bark extract, Angelica root extract, acetyl L-carnitine HCl, caffeine, L-theanine, Benfotiamine, and L-tetrahydropalmatine. The objective of this study was to compare the effects of Pain Bloc-R, acetaminophen, and placebo on unresolved aches and discomfort as assessed by the brief pain inventory (BPI) and modified Cornell musculoskeletal discomfort questionnaires. Read More

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The impact of sleep deprivation and alcohol on driving: a comparative study.

BMC Public Health 2020 Jun 22;20(1):980. Epub 2020 Jun 22.

The Centre for Forensic & Legal Medicine, 2 Park Pl, Dundee, DD1 4HR, Scotland.

Background: There is concern about the detrimental effects of shift-workers' increasing working hours particularly when driving sleep deprived. The approach to measuring the magnitude of driving impairment caused by sleep deprivation was by comparing it to alcohol. The study compared driving performance after 24-h of wakefulness to performance with a BrAC of just over 22 μg/100mls of breath which is equal to 50 mg of alcohol per 100mls of blood (Scottish drink-drive limit). Read More

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Occupational pesticide exposure and the risk of death in patients with Parkinson's disease: an observational study in southern Brazil.

Environ Health 2020 06 17;19(1):68. Epub 2020 Jun 17.

Departamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

Background: Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson's disease (PD) and may influence the progression of the disease. However, the evidence regarding the impact of pesticide exposure on mortality among patients with PD is equivocal. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil. Read More

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Glucose control upon waking is unaffected by hourly sleep fragmentation during the night, but is impaired by morning caffeinated coffee.

Br J Nutr 2020 11 1;124(10):1114-1120. Epub 2020 Jun 1.

Centre for Nutrition, Exercise & Metabolism, Department for Health, University of Bath, BathBA2 7AY, UK.

Morning coffee is a common remedy following disrupted sleep, yet each factor can independently impair glucose tolerance and insulin sensitivity in healthy adults. Remarkably, the combined effects of sleep fragmentation and coffee on glucose control upon waking per se have never been investigated. In a randomised crossover design, twenty-nine adults (mean age: 21 (sd 1) years, BMI: 24·4 (sd 3·3) kg/m2) underwent three oral glucose tolerance tests (OGTT). Read More

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November 2020

Caffeine Use and Associations With Sleep in Adolescents With and Without ADHD.

J Pediatr Psychol 2020 07;45(6):643-653

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.

Objective: The objective of this study was to compare caffeine consumption in the morning, afternoon, and evening in adolescents with and without attention-deficit/hyperactivity disorder (ADHD) and examine associations with sleep functioning.

Methods: Participants were 302 adolescents (ages 12-14) with (N = 140) and without (N = 162) ADHD. Adolescents wore actigraph watches to assess total sleep time and wake after sleep onset and reported on sleep-wake problems and the number of caffeinated beverages consumed per day in the morning, afternoon, and evening. Read More

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The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial.

Adv Ther 2020 06 24;37(6):2976-2987. Epub 2020 Apr 24.

Medical Consumer Health Care, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, Germany.

Introduction: A fixed dose combination (FDC) of ibuprofen 400 mg and caffeine 100 mg has been shown to be more effective than ibuprofen 400 mg alone for the treatment of acute postoperative dental pain in a phase III randomised controlled trial. A post hoc subgroup analysis of the primary data from an active-/placebo-controlled, double-blind, single-centre, parallel-group study was conducted in patients with moderate or severe baseline pain.

Methods: After dental surgery, patients with moderate or severe pain, which was determined on a 4-point verbal rating scale ('no pain' to 'severe pain'), received a single dose of ibuprofen 400 mg/caffeine 100 mg FDC, ibuprofen 400 mg, caffeine 100 mg or placebo. Read More

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Chest Pain From Supplement Use in an Active Duty Soldier: A Case Report.

Mil Med 2020 09;185(9-10):e1857-e1859

Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Dr, Fort Sam Houston, TX 78234.

In the active duty population, over-the-counter performance enhancing supplements are readily available and consumed, primarily in an unsupervised manner. While some of the active ingredients, such as caffeine and creatine, have been well studied, other sympathomimetic and vasoactive components in these products have minimal data regarding their safety profile. Further potentiating the associated risks of consumption, the quantities and purities of the reported ingredients are often unverified and can vary from serving to serving. Read More

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September 2020

Prevalence of primary dysmenorrhea and its effect on the quality of life amongst female medical students at King Saud University, Riyadh, Saudi Arabia. A cross-sectional study.

Saudi Med J 2020 Mar;41(3):283-289

College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To quantify the prevalence of primary dysmenorrhea, study its associated factors, and to assess its effect on the quality of life of female medical students.

Methods: A cross-sectional study was conducted among 376 female medical students at King Saud University student campus and King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia, between September 2017 and May 2018. The study was conducted using a consecutive, non-random sampling technique. Read More

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Bitter Taste Perception of the Human Tongue Mediated by Quinine and Caffeine Impregnated Taste Strips.

Ann Otol Rhinol Laryngol 2020 Aug 6;129(8):813-820. Epub 2020 Feb 6.

Institute of Clinical Pharmacology, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.

Objectives: Tests for gustatory function have become increasingly important in diagnosis and treatment of patients with taste disorders. While caffeine and quinine hydrochloride solutions have been used for global testing of bitter perception, only quinine has been used to test regional bitter perception by means of taste strips. The aim of the present study was to validate caffeine impregnated taste strips as an alternative to quinine taste strips for assessment of regional bitter perception. Read More

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Anti-inflammatory and central and peripheral anti-nociceptive activities of α-asarone through the inhibition of TNF-α production, leukocyte recruitment and iNOS expression, and participation of the adenosinergic and opioidergic systems.

Inflammopharmacology 2020 Aug 21;28(4):1039-1052. Epub 2019 Dec 21.

Laboratório de Farmacologia da Dor e Inflamação, Universidade Federal de São João del-Rei, Divinópolis, 35501-296, Brazil.

Alpha-asarone has been found to possess many pharmacological activities, which can improve cognitive function and exert anti-oxidant, anxiolytic, anti-epileptic and protective effects against endothelial cell injury. The anti-inflammatory activity of α-asarone was evaluated using lipopolysaccharide (LPS)-induced paw oedema. Moreover, leukocyte migration, inducible nitric oxide synthase (iNOS) expression and tumour necrosis factor-alpha (TNF-α) levels were quantified in footpads. Read More

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Antinociceptive, antiedematous, and antiallodynic activity of 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione derivatives in experimental models of pain.

Naunyn Schmiedebergs Arch Pharmacol 2020 05 19;393(5):813-827. Epub 2019 Dec 19.

Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688, Krakow, Poland.

The aim of the presented study was to examine the potential antinociceptive, antiedematous (anti-inflammatory), and antiallodynic activities of two 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione derivatives (DSZ 1 and DSZ 3) in various experimental models of pain. For this purpose, the hot plate test, the capsaicin test, the formalin test, the carrageenan model, and oxaliplatin-induced allodynia tests were performed. In the hot plate test, only DSZ 1 in the highest dose (20 mg/kg) was active but its effects appear to be due to sedatation rather than antinociceptiveness. Read More

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Effects of acute caffeine consumption following sleep loss on cognitive, physical, occupational and driving performance: A systematic review and meta-analysis.

Neurosci Biobehav Rev 2020 01 16;108:877-888. Epub 2019 Dec 16.

School of Allied Health Sciences, Griffith University, Gold Coast, Australia.

Caffeine is widely used to counteract the effects of sleep loss. This systematic review and meta-analysis examined the impact of acute caffeine consumption on cognitive, physical, occupational and driving performance in sleep deprived/restricted individuals. 45 publications providing 327 effect estimates (EEs) were included in the review. Read More

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January 2020

Reversible cerebral vasoconstriction syndrome after sudden caffeine withdrawal.

Br J Hosp Med (Lond) 2019 Dec;80(12):730-731

Consultant Neuroradiologist, Radiology Department, William Harvey Hospital, Ashford, Kent.

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December 2019


Samuel S Y Wang

J Sports Sci 2020 Jan 29;38(2):187-191. Epub 2019 Nov 29.

Department of Emergency Medicine, Prince of Wales Hospital, Sydney, Australia.

The popularity of pre-workout supplements is rising amongst professional athletes and fitness enthusiasts. Despite increased usage, the safety profile of pre-workout supplements is likely to be not well understood. Additionally, many different brands use various undisclosed proprietary blends of active ingredients creating safety regulation difficulties. Read More

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January 2020

Analgesic use at ovulation and implantation and human fertility.

Am J Obstet Gynecol 2020 05 15;222(5):476.e1-476.e11. Epub 2019 Nov 15.

Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.

Background: Studies investigating the effects of pain-relieving medication use on conceiving a pregnancy have shown conflicting results. Furthermore, no previous study has examined medication use around ovulation or implantation and the associations with the probability of conception, fecundability.

Objective: The objective of the study was to explore the association between fecundability and analgesic use in 3 different menstrual cycle windows (preovulation, periovulation, and implantation) as well as across the entire menstrual cycle. Read More

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Caffeine Exacerbates Postictal Hypoxia.

Neuroscience 2019 12 31;422:32-43. Epub 2019 Oct 31.

Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Electronic address:

A stroke-like event follows seizures which may be responsible for the postictal state and a contributing factor to the development of seizure-induced brain abnormalities and behavioral dysfunction associated with epilepsy. Caffeine is the world's most popular drug with ∼85% of people in the USA consuming it daily. Thus, persons with epilepsy are likely to have caffeine in their body and brain during seizures. Read More

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December 2019

Sleep Promoting Effect of Luteolin in Mice via Adenosine A1 and A2A Receptors.

Biomol Ther (Seoul) 2019 Nov;27(6):584-590

College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.

Luteolin, a widespread flavonoid, has been known to have neuroprotective activity against various neurologic diseases such as epilepsy, and Alzheimer's disease. However, little information is available regarding the hypnotic effect of luteolin. In this study, we evaluated the hypnotic effect of luteolin and its underlying mechanism. Read More

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November 2019

The effect of prenatal and postnatal caffeine exposure on pentylentetrazole induced seizures in the non-epileptic and epileptic offsprings.

Neurosci Lett 2019 11 17;713:134504. Epub 2019 Sep 17.

Department of Medical Pharmacology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Epilepsy Research Centre (EPAM), Marmara University, Istanbul, Turkey. Electronic address:

Caffeine, a central nervous system stimulant, has been reported to modulate seizure activity in various studies. In this study the effects of caffeine exposure on the pentylenetetrazole (PTZ) induced seizure thresholds and seizure stages in the Wistar and genetic absence epilepsy model offsprings were examined. Adult female and male Wistar rats and genetic absence epilepsy rats from Strasbourg (GAERS) consumed caffeine dissolved in water (0. Read More

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November 2019