6,136 results match your criteria Neurologic Effects of Caffeine

Effect of Caffeine Ingestion on Indirect Markers of Exercise-Induced Muscle Damage: A Systematic Review of Human Trials.

Nutrients 2022 Apr 23;14(9). Epub 2022 Apr 23.

Postgraduate Program in Physical Education, Center of Physical Education and Sports, Federal University of Espirito Santo, Vitória 29075-910, ES, Brazil.

The effect of caffeine on mitigating exercise-induced muscle damage (EIMD) is still poorly understood, but it was hypothesized that caffeine could contribute to decreasing delayed onset muscle soreness, attenuating temporary loss of strength, and reducing circulating levels of blood markers of muscle damage. However, evidence is not conclusive and beneficial effects of caffeine ingestion on EIMD are not always observed. Factors, such as the type of exercise that induces muscle damage, supplementation protocol, and type of marker analyzed contribute to the differences between the studies. Read More

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Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption.

Nutrients 2022 Mar 25;14(7). Epub 2022 Mar 25.

CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Rua Câmara Pestana 6, Edifício 2, piso 3, 1150-082 Lisboa, Portugal.

Daytime hypersomnolence, the prime feature of obstructive sleep apnea (OSA), frequently leads to high coffee consumption. Nevertheless, some clinicians ask for patients' caffeine avoidance. Caffeinated drinks are sometimes associated with more severe OSA. Read More

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Bright light alone or combined with caffeine improves sleepiness in chronically sleep-restricted young drivers.

Sleep Med 2022 May 24;93:15-25. Epub 2022 Mar 24.

The University of Queensland, Institute for Social Science Research (ISSR), Brisbane, Qld 4072, Australia.

Background: Young drivers are over-involved in sleepiness-related crashes. The alerting effects of bright light offer a potential countermeasure for driver sleepiness, either replacing or in conjunction with current countermeasures such as the use of caffeine.

Methods: Thirty young (18-25) chronically sleep-restricted drivers drove in a simulator under randomized conditions of continuous bright light ('Light,' 500 nm, 230μw/cm), caffeine ('Caffeine,' 100 mg caffeinated gum), or light and caffeine together ('Light + Caffeine'), after driving under a placebo condition ('Placebo,' decaffeinated gum, 555 nm light, 0. Read More

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Effects of caffeine ingestion on physiological indexes of human neuromuscular fatigue: A systematic review and meta-analysis.

Brain Behav 2022 Apr 23;12(4):e2529. Epub 2022 Mar 23.

College of Safety Science and Engineering, Civil Aviation University of China, Tianjin, China.

Background: Caffeine is often used as a stimulant during fatigue, but the standard of characteristic physiological indicators of the effect of caffeine on neuromuscular fatigue has not been unified. The purpose of this systematic review and meta-analysis is to summarize current experimental findings on the effects of caffeine on physiological indexes before and after neuromuscular fatigue, identify some characteristic neuromuscular physiological indexes to assess the potential effects of caffeine.

Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analyses are followed. Read More

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Acute caffeine supplementation and live match-play performance in team-sports: A systematic review (2000-2021).

J Sports Sci 2022 Apr 17;40(7):717-732. Epub 2022 Mar 17.

Department for Health, University of Bath, Bath, UK.

Caffeine is a psycho-active stimulant that can improve physical and cognitive performance. We systematically reviewed the evidence on the effects of acute caffeine ingestion on physiological parameters, physical and technical-skill performance during high-performance team-sport match-play. Following PRISMA guidelines, studies were identified using scientific databases (PubMed, Web-of-Science, Scopus, and SPORTDiscus) in February 2021. Read More

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Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update.

Nutrients 2022 Jan 26;14(3). Epub 2022 Jan 26.

Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur 56000, Malaysia.

Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. Read More

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January 2022

Caffeine intake and its influences on heart rate variability recovery in healthy active adults after exercise: A systematic review and meta-analysis.

Nutr Metab Cardiovasc Dis 2022 05 22;32(5):1071-1082. Epub 2022 Jan 22.

Autonomic Nervous System Center, UNESP, Marilia, SP, Brazil. Electronic address:

Aims: Results regarding the effects of caffeine (CAF) intake on the autonomic control of heart rate recovery exercise remain inconclusive. Thus far, no study has used effect measures to pool the results of different experiments. We aim to assess the acute effect of CAF intake before exercise on the recovery of heart rate variability (HRV) after exercise through a systematic review and meta-analysis. Read More

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Comment on Kopańska et al. Disorders of the Cholinergic System in COVID-19 Era-A Review of the Latest Research. 2022, , 672.

Int J Mol Sci 2022 Mar 4;23(5). Epub 2022 Mar 4.

Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy.

We read the recent review article by Marta Kopańska et al. [.. Read More

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Recent advances in the utilization of tea active ingredients to regulate sleep through neuroendocrine pathway, immune system and intestinal microbiota.

Crit Rev Food Sci Nutr 2022 Mar 10:1-29. Epub 2022 Mar 10.

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, P.R. China.

Sleep disorders have received widespread attention nowadays, which have been promoted by the accelerated pace of life, unhealthy diets and lack of exercise in modern society. The chemical medications to improve sleep has shown serious side effects and risks with high costs. Therefore, it is urgent to develop efficient nutraceuticals from natural sources to ensure sleep quality as a sustainable strategy. Read More

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Impact of energy drink versus coffee consumption on periodic repolarization dynamics: an interventional study.

Eur J Nutr 2022 Mar 10. Epub 2022 Mar 10.

Department of Medicine I, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.

Purpose: Caffeinated beverages are consumed daily throughout the world. Caffeine consumption has been linked to dysfunction of the autonomic nervous system. However, the exact effects are still insufficiently understood. Read More

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Aminophylline in combination with caffeine citrate in neurodevelopmental treatment and follow-up of high-risk preterm infants using GMs assessment.

Pak J Pharm Sci 2022 Jan;35(1(Special)):361-364

Department of Maternal and Child Health Care, Shiyan Maternal and Child Health Hospital, Shiyan, Hubei, China.

To explore the application effect of aminophylline combined with caffeine citrate and GMs in the evaluation of neurodevelopmental treatment and follow-up in high-risk preterm infants. A retrospective analysis of 66 high-risk preterm infants admitted to Hengshui People's Hospital from January 2020 to June 2021 was conducted. The children who received only conventional treatment were set as the control group, while those who received aminophylline and caffeine citrate on the basis of conventional treatment were set as the experimental group, 33 cases each group; GMs were used to evaluate the neurodevelopmental function of the children, and the treatment effect was analyzed. Read More

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January 2022

Nonopioid drugs for pain.


Med Lett Drugs Ther 2022 03;64(1645):33-40

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Caffeine and MDMA (Ecstasy) Exacerbate ER Stress Triggered by Hyperthermia.

Int J Mol Sci 2022 Feb 10;23(4). Epub 2022 Feb 10.

Molecular Mechanisms of Cellular Stress and Inflammation Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

Drugs of abuse can cause local and systemic hyperthermia, a known trigger of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). Another trigger of ER stress and UPR is ER calcium depletion, which causes ER exodosis, the secretion of ER-resident proteins. In rodent models, club drugs such as 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') can create hyperthermic conditions in the brain and cause toxicity that is affected by the environmental temperature and the presence of other drugs, such as caffeine. Read More

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February 2022

Time to Recover From Daily Caffeine Intake.

Front Nutr 2021 2;8:787225. Epub 2022 Feb 2.

Centre for Chronobiology, University Psychiatric Clinics Basel, Basel, Switzerland.

Caffeine elicits widespread effects in the central nervous system and is the most frequently consumed psychostimulant worldwide. First evidence indicates that, during daily intake, the elimination of caffeine may slow down, and the primary metabolite, paraxanthine, may accumulate. The neural impact of such adaptions is virtually unexplored. Read More

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February 2022

A Neurochemical and Electrophysiological Study on the Combined Effects of Caffeine and Nicotine in the Cortex of Rats.

Basic Clin Neurosci 2021 Sep-Oct;12(5):681-692. Epub 2021 Sep 1.

Department of Medical Physiology, Medical Division, National Research Center, Egypt.

Introduction: Caffeine and nicotine are the most widely consumed psychostimulants worldwide. Although the effects of each drug alone on the central nervous system have been studied extensively, the literature on the neurochemical and electrophysiological effects of their combined treatments is scarce. The present study investigated the cortical electrophysiological and neurochemical alterations induced by acute administration of caffeine and nicotine in rats. Read More

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September 2021

Striatal Indirect Pathway Dysfunction Underlies Motor Deficits in a Mouse Model of Paroxysmal Dyskinesia.

J Neurosci 2022 03 14;42(13):2835-2848. Epub 2022 Feb 14.

UCSF Neuroscience Graduate Program

Abnormal involuntary movements, or dyskinesias, are seen in many neurologic diseases, including disorders where the brain appears grossly normal. This observation suggests that alterations in neural activity or connectivity may underlie dyskinesias. One influential model proposes that involuntary movements are driven by an imbalance in the activity of striatal direct and indirect pathway neurons (dMSNs and iMSNs, respectively). Read More

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Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice.

Molecules 2022 Feb 1;27(3). Epub 2022 Feb 1.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

The use of natural products as therapeutic agents is rapidly growing recently. In the current study, we investigated the protective effects of green tea supplementation on lead-induced toxicity in mice. Forty albino mice were divided into four groups as follows: A: control group; B: green tea receiving group; C: lead-intoxicated group; and D: lead-intoxicated group supplemented with green tea. Read More

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February 2022

Central Nervous System Stimulants Limit Caffeine Transport at the Blood-Cerebrospinal Fluid Barrier.

Int J Mol Sci 2022 Feb 7;23(3). Epub 2022 Feb 7.

Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka 545-8585, Japan.

Caffeine, a common ingredient in energy drinks, crosses the blood-brain barrier easily, but the kinetics of caffeine across the blood-cerebrospinal fluid barrier (BCSFB) has not been investigated. Therefore, 127 autopsy cases (Group A, 30 patients, stimulant-detected group; and Group B, 97 patients, no stimulant detected group) were examined. In addition, a BCSFB model was constructed using human vascular endothelial cells and human choroid plexus epithelial cells separated by a filter, and the kinetics of caffeine in the BCSFB and the effects of 4-aminopyridine (4-AP), a neuroexcitatory agent, were studied. Read More

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February 2022

Safety, Pharmacokinetic, and Pharmacodynamic Study of a Sublingual Formula for the Treatment of Vasovagal Syncope.

Drugs R D 2022 Mar 12;22(1):61-70. Epub 2022 Feb 12.

Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI, 53792, USA.

Background: Vasovagal syncope is a common cause of syncope which, if recurrent, can have multiple negative consequences such as injury and occupational disability. Various medications can be used to decrease the recurrence of vasovagal syncope but there are no drugs that can be used by patients to interrupt a perceived vasovagal episode.

Methods: A phase I study was performed to evaluate the tolerability and safety of a gel formulation containing capsaicin (1 mg), phenylephrine HCL (PE) and caffeine citrate (200 mg) (CPC) in normal adult volunteers. Read More

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Application of dose-addition analyses to characterize the abuse-related effects of drug mixtures.

J Exp Anal Behav 2022 05 10;117(3):442-456. Epub 2022 Feb 10.

Department of Pharmacology, University of Texas Health Science Center at San Antonio.

Polysubstance use makes up a majority of drug use, yet relatively few studies investigate the abuse-related effects of drug mixtures. Dose-addition analyses provide a rigorous and quantitative method to determine the nature of the interaction (i.e. Read More

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Effect of caffeine and caffeine cessation on cerebrovascular reactivity in patients with migraine.

Headache 2022 02 3;62(2):169-175. Epub 2022 Feb 3.

Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objective: To investigate the effect of chronic caffeine use and caffeine cessation on vasodilatory function in the posterior circulation in patients with migraine.

Background: Studies regarding cerebrovascular reactivity (CVR) using vasodilatory stimuli in patients with migraine have yielded conflicting results. We postulated that CVR may not be static, and caffeine might negatively affect vasodilatory function via its vasoconstrictive effect. Read More

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February 2022

Investigation of potential behavioral and physiological effects of caffeine on D. magna.

Environ Sci Pollut Res Int 2022 Jan 29. Epub 2022 Jan 29.

Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal.

With the ever-increasing consumption of pharmaceutical compounds, their presence in the environment is now an undisputable reality. The majority of these compounds are released into the wild after their therapeutic use, as biotransformation products or in their original form. The presence of this class of compounds in the environment, due to their biological properties, can exert effects on non-target organisms, with adverse consequences. Read More

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January 2022

Caffeine Protects Against Retinal Inflammation.

Front Pharmacol 2021 6;12:824885. Epub 2022 Jan 6.

Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.

Caffeine, one of the most consumed central nervous system (CNS) stimulants, is an antagonist of A and A adenosine receptors. In this study, we investigated the potential protective effects of this methylxanthine in the retinal tissue. We tested caffeine by using and paradigms of retinal inflammation. Read More

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January 2022

Disorders of the Cholinergic System in COVID-19 Era-A Review of the Latest Research.

Int J Mol Sci 2022 Jan 8;23(2). Epub 2022 Jan 8.

Departament of Biology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-959 Rzeszow, Poland.

The appearance of the SARS-CoV-2 virus initiated many studies on the effects of the virus on the human body. So far, its negative influence on the functioning of many morphological and physiological units, including the nervous system, has been demonstrated. Consequently, research has been conducted on the changes that SARS-CoV-2 may cause in the cholinergic system. Read More

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January 2022

Methodological review of caffeine assessment strategies with a focus on adolescents.

Sleep Med Rev 2022 Apr 5;62:101587. Epub 2022 Jan 5.

Department of Psychology, Loyola University Maryland, Baltimore, MD, USA. Electronic address:

Adolescent caffeine use and its implications for developmental changes in sleep and circadian rhythms is under-researched. A majority of adolescents report consuming caffeine and yet the United States has not established federal guidelines for this age group. This widely used stimulant is primarily studied using self-report methodologies; however, there is no standardized method for collecting self-report caffeine data and past studies' findings have limited generalizability and comparability, making it challenging to examine the effects of caffeine use on adolescents' sleep. Read More

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Electrophysiological Monitoring of Neurochemical-Based Neural Signal Transmission in a Human Brain-Spinal Cord Assembloid.

ACS Sens 2022 02 19;7(2):409-414. Epub 2022 Jan 19.

Department of Chemical & Biomolecular Engineering, Sogang University, Seoul, 04107, Republic of Korea.

Combining human brain organoids holds great potential in recapitulating the human brain's histological features and modeling neural disorders. However, current combined-brain organoid models focus on the internal interactions between different brain regions. In this study, we develop an engineered brain-spinal cord assembloid (eBSA) by coculturing cerebral organoids (COs) and motor neuron spheroids (MNSs). Read More

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February 2022

Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study.

Pain Res Manag 2022 4;2022:6107292. Epub 2022 Jan 4.

Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.

Several factors might influence the duration and efficiency of local anesthesia. This study investigates the effect of habitual caffeine intake on lidocaine action and explores the potential involvement of voltage-gated sodium channels in the interaction effect. Wistar rats were divided into four groups: (i) control (Ctrl), (ii) lidocaine intraplantar injection (LIDO), (iii) habitual caffeine intake (CAF), and (iv) lidocaine intraplantar injection and habitual caffeine intake (LIDO + CAF). Read More

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Hot and Cold Theory: Evidence in Nutrition.

Adv Exp Med Biol 2021 ;1343:87-107

NICM Health Research Institute, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.

Ancient scholars across cultures have postulated that by being less potent versions of herbs, food plays a substantive role in the maintenance of health and treatment of disease. A commonality among these traditional medical systems is in relation to the 'heating' and 'cooling' properties of foods. In this chapter, 'hot' and 'cold' classifications of foods are explored, along with ways to optimize health and combat disease. Read More

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January 2022

Pharmacokinetic, pharmacological, and genotoxic evaluation of deuterated caffeine.

Food Chem Toxicol 2022 Feb 30;160:112774. Epub 2021 Dec 30.

Burdock Group, 859 Outer Road Orlando, FL, 32814, USA. Electronic address:

Altering caffeine's negative physiological effects and extending its duration of activity is an active area of research; however, deuteration as a means of achieving these goals is unexplored. Deuteration substitutes one or more of the hydrogen atoms of a substance with deuterium, a stable isotope of hydrogen that contains an extra neutron. Deuteration can potentially alter the metabolic profile of a substance, while maintaining its pharmacodynamic properties. Read More

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February 2022