588 results match your criteria Neurologic Complications of Organ Transplantation


Spinal Cord Ischemia Because of Microvascular Thrombosis in a Patient with Necrotizing Pancreatitis. Case Report and Literature Review.

Am J Case Rep 2020 May 12;21:e923273. Epub 2020 May 12.

Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND Central nervous system ischemia in acute pancreatitis is rare with only a handful of cases reported in the literature. We report a case of spinal cord ischemia due to microvascular thrombosis complicating acute on chronic pancreatitis. CASE REPORT A 37-year-old male was transferred to a university hospital intensive care unit with a diagnosis of acute onset chronic pancreatitis, paraplegia, and multi-organ failure. Read More

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http://dx.doi.org/10.12659/AJCR.923273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252832PMC

Factors Associated With Neurobehavioral Complications in Pediatric Abdominal Organ Transplant Recipients Identified Using Computable Composite Definitions.

Pediatr Crit Care Med 2020 Apr 23. Epub 2020 Apr 23.

Department of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Objectives: Neurologic complications occur in up to 40% of adult abdominal solid organ transplant recipients and are associated with increased mortality. Comparable pediatric data are sparse. This study describes the occurrence of neurologic and behavioral complications (neurobehavioral complications) in pediatric abdominal solid organ transplant recipients. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002355DOI Listing

Acute liver failure due to DGUOK deficiency-is liver transplantation justified?

Clin Res Hepatol Gastroenterol 2020 Apr 8. Epub 2020 Apr 8.

Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, Children's Memorial Health Institute, Al. Dzieci Polskich 20, Warsaw, Poland.

Background: Deoxyguanosine kinase (DGUOK) deficiency is one of the causes of the hepatocerebral form of mitochondrial depletion syndrome (MDS). It is characterized by an early onset of liver failure with concomitant neurological deterioration. In the current literature, there are only few reports regarding long-term observation of children with DGUOK deficiency. Read More

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http://dx.doi.org/10.1016/j.clinre.2020.02.018DOI Listing

Imaging Assessment of Complications from Transplantation from Pediatric to Adult Patients: Part 2: Hematopoietic Stem Cell Transplantation.

Radiol Clin North Am 2020 May 26;58(3):569-582. Epub 2020 Feb 26.

St. Luke's Medical Center College of Medicine-William H. Quasha Memorial, Quezon City, Philippines; Philippine Society for Pediatric Radiology; Section of Pediatric Radiology, Institute of Radiology, St. Luke's Medical Center-Quezon City, 279 East Rodriguez Sr. Avenue, Quezon City 1112, Philippines.

Hematopoietic stem cell transplantation is an intravenous transfusion of pluripotent stem cells to repopulate the marrow and restore immunocompetence. However, before transplantation, the patient undergoes a conditioning regimen to eradicate the underlying disease, subsequently resulting in an immunocompromised state. Serious and some life-threatening complications involving any organ can occur. Read More

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http://dx.doi.org/10.1016/j.rcl.2019.12.006DOI Listing

Face transplantation: general review and long-term management of the dental patient.

Quintessence Int 2020 ;51(4):334-342

Facial allotransplantation (FA) is an emerging alternative modality following severe loss of hard and soft tissues. Although there are vast numbers of publications on the surgical aspects of this technique, limited information is available in the literature with regard to the long-term dental care of affected patients following postoperative stabilization and return to their locally based clinical milieu. The objective of this report is to review patient demographics, etiologies, structural graft components, immunosuppressive strategies, donor tissue pathogenicity, neurologic recovery, potential complications, and present clinical guidelines for dental management. Read More

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http://dx.doi.org/10.3290/j.qi.a44143DOI Listing

Adult complications of nephropathic cystinosis: a systematic review.

Pediatr Nephrol 2020 Feb 3. Epub 2020 Feb 3.

Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

While nephropathic cystinosis is classically thought of as a childhood disease, with improved treatments, patients are more commonly living into adulthood. We performed a systematic review of the literature available on what complications this population faces as it ages. Nearly every organ system is affected in cystinosis, either from the disease itself or from sequelae of kidney transplantation. Read More

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http://dx.doi.org/10.1007/s00467-020-04487-6DOI Listing
February 2020

Elevation of Preoperative Ammonia Level Is Not Associated With the Incidence of Postoperative Delirium in Patients with Liver Transplantation: A Propensity Score Matching Analysis.

Transplant Proc 2020 Jan - Feb;52(1):219-226. Epub 2019 Dec 27.

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.

Introduction: The preoperative elevation of ammonia may be associated with postoperative neurologic complications. The aim of this study was to evaluate the effect of preoperative ammonia level on the incidence of delirium in patients after liver transplantation (LT).

Materials And Methods: Patients (n = 260) who received LT from January 2010 to July 2017 in a single university hospital were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.11.012DOI Listing

Lethal thrombosis of the iliac artery caused by Aspergillus fumigatus after liver transplantation: case report and review of the literature.

BMC Surg 2019 Dec 27;19(1):200. Epub 2019 Dec 27.

Department of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Medical Center Schleswig-Holstein (UKSH), Campus Kiel, and Christian-Albrecht University (CAU), Arnold-Heller-Str. 3, 24105, Kiel, Germany.

Background: Aspergillus fumigatus infections frequently occur after solid organ transplantation. Yet, a fungal thrombosis after liver transplantation is an exceptional finding.

Case Presentation: We report on a 44-year-old female with an aspergillosis after liver transplantation for autoimmune hepatitis. Read More

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http://dx.doi.org/10.1186/s12893-019-0668-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935117PMC
December 2019

Postoperative management of lung transplant recipients.

J Thorac Dis 2019 Sep;11(Suppl 14):S1782-S1788

Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Despite advances in surgical technique, lung transplantation is associated with worse survival when compared with other solid organ transplantations. Graft dysfunction and infection are the leading causes of mortality in the first 30 days following transplantation. Primary graft dysfunction (PGD) is a form of reperfusion injury that occurs early after transplantation. Read More

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http://dx.doi.org/10.21037/jtd.2019.05.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783721PMC
September 2019

Multiple Brain Biopsies for Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma with Extensive Necrosis in a Posttransplant Patient.

World Neurosurg 2020 Jan 21;133:10-13. Epub 2019 Sep 21.

Department of Pathology, Chonnam National University Hospital and Chonnam National University Hwasun and Medical School, Gwangju, Republic of Korea.

Background: Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) in an immunocompromised patient with organ transplantation demonstrated unusual brain magnetic resonance imaging (MRI) findings. Recognition of EBV-positive DLBCL by radiologists on MRI may prevent unnecessary neurosurgical resection, and it could be important to obtain viable cells for accurate diagnosis on stereotactic biopsy because of extensive necrosis.

Case Description: A 62-year-old woman presented to the emergency department with left hemiparesis grade III and dysarthria lasting for 3 weeks. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.09.084DOI Listing
January 2020
3 Reads

Glycogen storage disease type IV: dilated cardiomyopathy as the isolated initial presentation in an adult patient.

BMJ Case Rep 2019 Sep 16;12(9). Epub 2019 Sep 16.

Pathology, University of Washington, Seattle, Washington, USA.

Glycogen storage disease type IV (GSD IV, Andersen disease) is a rare autosomal recessive condition. The childhood neuromuscular subtype of GSD IV is characterised by a progressive skeletal myopathy with cardiomyopathy also reported in some individuals. We report a case of a 19-year-old man who presented with severe non-ischaemic dilated cardiomyopathy (NIDCM) necessitating heart transplantation, with biopsy showing aggregations of polyglucosan bodies in cardiac myocytes. Read More

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http://dx.doi.org/10.1136/bcr-2019-230068DOI Listing
September 2019
4 Reads

Complications for a Hoyeraal-Hreidarsson Syndrome Patient with a Germline A353V Variant Undergoing Unrelated Peripheral Blood Stem Cell Transplantation.

Int J Mol Sci 2019 Jul 2;20(13). Epub 2019 Jul 2.

Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.

Hoyeraal-Hreidarsson syndrome (HHS), caused by several different germline mutations resulting in severe telomeropathy, presents with early-onset growth anomalies and neurologic/developmental disorders including characteristic cerebellar hypoplasia. Early mortalities may arise from immunodeficiency and bone marrow failure if not successfully salvaged by allogeneic hematopoietic stem cell transplantation (HSCT). Few reports have characterized the persistent somatic progression of HHS after successful HSCT. Read More

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http://dx.doi.org/10.3390/ijms20133261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651050PMC
July 2019
7 Reads

Cardiac and Neurologic Complications in the Late Period After Liver Transplantation: A Retrospective Analysis of 4 Years.

Transplant Proc 2019 May 22;51(4):1153-1156. Epub 2019 Feb 22.

Department of General Surgery, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Background And Objective: The aim of our study was to assess the cardiac and neurologic complications after liver transplantation in the late period.

Method And Patients: Medical records of 198 patients who had liver transplantation in the organ transplantation center of our university hospital between between February 2014 and October 2017 were reviewed retrospectively. Patients who were consulted by a physician from either the cardiology or neurology departments during their long-term follow-up after liver transplantation were included in the study. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.02.010DOI Listing
May 2019
5 Reads

Cardiovascular and Neurologic Complications in Kidney Transplant Recipients: A Focused Appraisal of Symptoms.

Transplant Proc 2019 May 8;51(4):1101-1107. Epub 2019 Feb 8.

Department of General Surgery, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Background And Objective: After a kidney transplantation, all efforts are focused on graft function. However, cardiovascular and neurologic complications might lead to decreased quality of life and shortened life expectancy. Early recognition of related symptoms might be critical to successfully manage these complications. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.02.005DOI Listing
May 2019
4 Reads

Neurological Complications After Renal Transplantation: A Systematic Review and Meta-Analysis.

Ther Apher Dial 2019 Dec 4;23(6):518-528. Epub 2019 Jul 4.

Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran.

The aim of this systematic review and meta-analysis was to evaluate the prevalence of neurological complication after renal transplantation. The searches were conducted by two independent researchers in the international (PubMed, Web of Science, Scopus, and Google Scholar) and national databases (Magiran and SID) to find the relevant studies published in English and Persian languages since the creation of the databases until January 2019 (without time limitations). The keywords used in the search strategy were: neurologic complication, central nervous system, peripheral nervous system, tremor, CVA, encephalopathy, neurological complications, renal transplantation, renal failure, kidney transplantation, immunosuppression, neurotoxicity, opportunistic infections, CNS, cerebrovascular disease, chronic kidney disease, cognitive impairment, and end-stage renal disease, which were combined using the AND, OR, and NOT operators. Read More

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http://dx.doi.org/10.1111/1744-9987.12838DOI Listing
December 2019
10 Reads

Neurologic complications of kidney transplantation.

Transl Androl Urol 2019 Apr;8(2):164-172

Cleveland Clinic Foundation, Cleveland, OH, USA.

Renal transplant is the most common organ transplant in the United States, and the frequency of kidney transplants continues to rise as transplant offers improved survival and quality of life compared to dialysis. However, complications are not uncommon and patients frequently encounter issues requiring hospitalization, especially in the first year postoperatively. Complications that arise are typically related to surgical complications, immunosuppressive medications, or infection due to immunosuppression. Read More

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http://dx.doi.org/10.21037/tau.2018.08.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503229PMC
April 2019
13 Reads

Salvage of renal transplant with vacuum-assisted thrombectomy of large iliocaval and allograft venous outflow thrombus.

Diagn Interv Radiol 2019 May;25(3):238-241

Department of Radiology, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.

A 47-year-old male with a remote renal transplant due to pediatric glomerulonephritis on oral anticoagulation for symptomatic deep venous thrombosis and pulmonary emboli presented with sudden hip and groin pain. The patient was found to have a spinal epidural hematoma, underwent reversal of anticoagulation, and subsequently developed worsening renal function. Imaging revealed occlusive iliocaval venous thrombosis with extension to the renal allograft. Read More

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http://dx.doi.org/10.5152/dir.2019.18232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521902PMC
May 2019
10 Reads

Pathophysiology and Management of Hyperammonemia in Organ Transplant Patients.

Am J Kidney Dis 2019 09 27;74(3):390-398. Epub 2019 Apr 27.

Division of Nephrology, Department of Internal Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Neurologic complications are common after solid-organ transplantation, occurring in one-third of patients. Immunosuppression-related neurotoxicity (involving calcineurin inhibitors and corticosteroids), opportunistic central nervous system infections, seizures, and delirium are some of the causes of neurologic symptoms following solid-organ transplantation. An uncommon often missed complication posttransplantation involves buildup of ammonia levels that can lead to rapid clinical deterioration even when treated. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.03.419DOI Listing
September 2019
12 Reads

Experience with the HeartMate II Left Ventricular Assist Device in Patients Older than 60 Years.

Heart Surg Forum 2019 03 8;22(2):E124-E130. Epub 2019 Mar 8.

Division of Cardiothoracic Transplantation and Circulatory Support Baylor College of Medicine Houston, Texas, USA.

Background: Advanced age is a relative contraindication for heart transplantation, but no age cutoff has been defined for patients receiving mechanical circulatory support.

Methods: Between November 1, 2003 and November 1, 2012, we implanted the HeartMate II (HMII) left ventricular assist device (LVAD) in 319 patients. One hundred seven patients (89 men, 18 women) were over 60 years old (mean, 66 ± 4 years, range, 61-78 years) and received the HMII as a bridge to transplantation (n = 45) or as destination therapy (n = 62). Read More

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http://dx.doi.org/10.1532/hsf.2297DOI Listing
March 2019
5 Reads

Surgical Decision Making: Thymoma and Myasthenia Gravis.

Thorac Surg Clin 2019 May 7;29(2):203-213. Epub 2019 Mar 7.

Thoracic Surgery Unit, Department of Cardiologic, Thoracic and Vascular Sciences, University Hospital, Padova, Italy. Electronic address:

About 15% of patients with myasthenia gravis are affected by thymoma. Precise tumor staging is necessary to plan the appropriate operation. In early stages, complete surgical resection is the mainstay of treatment. Read More

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http://dx.doi.org/10.1016/j.thorsurg.2018.12.007DOI Listing
May 2019
23 Reads

Association of Appendicitis, Helicobacter Pylori Positive Gastritis and Thrombotic Thrombocytopenic Purpura in an Adolescent.

Am J Case Rep 2019 Jan 31;20:131-133. Epub 2019 Jan 31.

Department of Nephrology, University Hospital in Split, Split, Croatia.

BACKGROUND Thrombotic thrombocytopenic purpura (TTP) in children is a rare life-threatening syndrome, characterized by microangiopathic hemolytic anemia, thrombocytopenia with renal dysfunction, neurologic symptoms, and fever. TTP is usually caused by deficient activity of von Willebrand factor cleaving protease (ADAMTS13), due to either gene mutations or acquired via anti-ADAMTS13 autoantibodies. It can be triggered by bone marrow or solid organ transplantation, cardiothoracic-, abdominal-, and orthopedic surgeries, infections including very rarely Helicobacter pylori infection. Read More

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http://dx.doi.org/10.12659/AJCR.913129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364441PMC
January 2019
8 Reads

Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management.

Blood Rev 2019 03 14;34:45-55. Epub 2018 Nov 14.

Experimental Transplantation and Immunology Branch, National Cancer Institute, Building 10, Suite 3-3330, Bethesda, MD 20892, United States. Electronic address:

Chimeric antigen receptor (CAR) T-cell therapy is an effective new treatment for hematologic malignancies. Two CAR T-cell products are now approved for clinical use by the U.S. Read More

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http://dx.doi.org/10.1016/j.blre.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628697PMC
March 2019
15 Reads

Application of Muse Cell Therapy to Stroke.

Adv Exp Med Biol 2018;1103:167-186

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Stroke is defined as a sudden onset of neurologic deficits arising from cerebrovascular complications. It is the second common cause of death around the world and the major cause of disability. Because brain is an organ with complicated neural networks and neurons are highly differentiated, it has been traditionally considered to possess a limited potential for regeneration. Read More

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http://dx.doi.org/10.1007/978-4-431-56847-6_9DOI Listing
July 2019
8 Reads

Complications of Solid Organ Transplantation: Cardiovascular, Neurologic, Renal, and Gastrointestinal.

Crit Care Clin 2019 Jan 25;35(1):169-186. Epub 2018 Oct 25.

Department of Critical Care Medicine, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Despite improvements in overall graft function and patient survival rates after solid organ transplantation, complications can lead to significant morbidity and mortality. Cardiovascular complications include heart failure, arrhythmias leading to sudden death, hypertension, left ventricular hypertrophy, and allograft vasculopathy in heart transplantation. Neurologic complications include stroke, posterior reversible encephalopathy syndrome, infections, neuromuscular disease, seizure disorders, and neoplastic disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07490704183074
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http://dx.doi.org/10.1016/j.ccc.2018.08.011DOI Listing
January 2019
47 Reads

Acute liver failure: A review for emergency physicians.

Am J Emerg Med 2019 02 22;37(2):329-337. Epub 2018 Oct 22.

Brooke Army Medical Center, Department of Emergency Medicine, 3841 Roger Brooke Dr, Fort Sam Houston, TX 78234, United States. Electronic address:

Introduction: Acute liver failure (ALF) remains a high-risk clinical presentation, and many patients require emergency department (ED) management for complications and stabilization.

Objective: This narrative review provides an evidence-based summary of the current data for the emergency medicine evaluation and management of ALF.

Discussion: While ALF remains a rare clinical presentation, surveillance data suggest an overall incidence between 1 and 6 cases per million people every year, accounting for 6% of liver-related deaths and 7% of orthotopic liver transplants (OLT) in the U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07356757183084
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http://dx.doi.org/10.1016/j.ajem.2018.10.032DOI Listing
February 2019
34 Reads

A pediatric neurologic assessment score may drive the eculizumab-based treatment of Escherichia coli-related hemolytic uremic syndrome with neurological involvement.

Pediatr Nephrol 2019 03 25;34(3):517-527. Epub 2018 Oct 25.

Pediatric Nephrology and Dialysis Unit, Pediatric Hospital "Giovanni XXIII", Bari, Italy.

Background: Thrombotic microangiopathy (TMA) is a clinical syndrome encompassing a large group of rare but severe disorders including thrombotic thrombocytopenic purpura (TTP) and both typical and atypical forms of hemolytic uremic syndrome (HUS). The key role of the complement system is well known in TTP and atypical HUS, but recent reports describe its involvement in the pathogenesis of HUS secondary to gastrointestinal infections due to Shiga toxin-producing Escherichia coli (STEC).

Methods: TMA mainly affects the kidney, but extra-renal complications are frequently described. Read More

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http://link.springer.com/10.1007/s00467-018-4112-2
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http://dx.doi.org/10.1007/s00467-018-4112-2DOI Listing
March 2019
20 Reads

The Use of Donation After Circulatory Death Organs for Simultaneous Liver-kidney Transplant: To DCD or Not to DCD?

Transplantation 2019 06;103(6):1159-1167

Department of Medicine, Dalhousie University, Halifax, Nova Scotia., Canada.

Background: Because of the challenges with organ scarcity, many centers performing simultaneous liver-kidney transplant (SLKT) are opting to accept donation after circulatory death (DCD) organs as a means of facilitating earlier transplant and reducing death rates on the waitlist. It has been suggested, however, that DCD organs may have inferior graft and patient survival posttransplant compared with donation after neurologic death (DND) organs.

Methods: We created a Markov model to compare the overall outcomes of accepting a DCD SLKT now versus waiting for a DND SLKT in patients waitlisted for SLKT, stratified by base Model for End-Stage Liver Disease (MELD) score (≤20, 21-30, >30). Read More

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http://dx.doi.org/10.1097/TP.0000000000002434DOI Listing
June 2019
5 Reads

Hyponatremia in Cirrhosis: Implications for Liver Transplantation.

Liver Transpl 2018 11;24(11):1612-1621

GI/Liver Unit, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Hyponatremia in cirrhosis is defined as a serum sodium level ≤130 mEq/L and occurs in approximately 22% of patients with cirrhosis. The appearance of hyponatremia in patients with cirrhosis portends a poor prognosis before liver transplantation (LT), independent of the Model for End-Stage Liver Disease (MELD) score. With the development of the MELD-sodium score, the management of hyponatremia has become more relevant than ever before. Read More

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http://dx.doi.org/10.1002/lt.25327DOI Listing
November 2018
27 Reads

Are two internal thoracic grafts better than one in patients with chronic obstructive lung disease? Analysis of 387 cases between 1996-2011.

PLoS One 2018 13;13(8):e0201227. Epub 2018 Aug 13.

Department of Cardiothoracic Surgery Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Objectives: Bilateral internal thoracic artery (ITA) grafting is associated with improved survival. However, potential survival benefit of using two ITA`s in patients with chronic lung disease (CLD) is questionable due to their increased risk of sternal wound infection (SWI) compared to operations incorporating single ITA (SITA). The purpose of this study is to compare early and long-term outcome of bilateral internal thoracic artery (BITA) grafting to that of grafting with single internal thoracic grafts and vein grafts or radial artery (SITA) in CLD patients with multi-vessels coronary disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201227PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089414PMC
February 2019
13 Reads

High Incidence of Early Human Herpesvirus-6 Infection in Children Undergoing Haploidentical Manipulated Stem Cell Transplantation for Hematologic Malignancies.

Biol Blood Marrow Transplant 2018 12 29;24(12):2549-2557. Epub 2018 Jul 29.

Pediatric Hematology-Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Human herpesvirus-6 (HHV-6) infection is increasingly recognized among allogeneic hematopoietic stem cell transplantation (HSCT) recipients, with 30% at risk of reactivation in the haploidentical setting. It has been associated with encephalitis, acute graft-versus-host disease, and graft failure. Here we report 2 cohorts of pediatric haploidentical manipulated HSCT in which, despite many differences, HHV-6 reactivation and disease occurred with very high incidence compared with data reported in the literature and represented the main early post-transplant infectious complication compared with other viral, bacterial, or fungal infections. Read More

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http://dx.doi.org/10.1016/j.bbmt.2018.07.033DOI Listing
December 2018
17 Reads
3.404 Impact Factor

Emergent Neuroimaging in the Oncologic and Immunosuppressed Patient.

Neuroimaging Clin N Am 2018 Aug;28(3):397-417

Neuroradiology Division, Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Neuroimaging in the emergency department increasingly involves patients at increased risk for acute neurologic complications from malignancy and immunosuppression, including patients with organ transplantation, diabetes mellitus, treatment of chronic disease, and HIV positivity. These patients are susceptible to the same infections and emergencies as immunocompetent patients, but may present differently with common illnesses and are susceptible to a variety of other diseases. This article reviews important patient risk factors, emergent central nervous system abnormalities, and their imaging findings. Read More

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http://dx.doi.org/10.1016/j.nic.2018.03.004DOI Listing
August 2018
19 Reads

Assessing the Benefits of Preoperative Thoracic Epidural Placement for Lung Transplantation.

J Cardiothorac Vasc Anesth 2018 12 3;32(6):2654-2661. Epub 2018 Apr 3.

Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA.

Objective: The authors investigated the effect of preoperative thoracic epidural (PreTE) catheter placement versus not placing a preoperative thoracic epidural catheter (NoPreTE) on the duration of postoperative ventilation time, time to become coherent (measured as time to become Confusion Assessment Method-intensive care unit [ICU] negative), opioid consumption, ICU length of stay (LOS), and hospital LOS.

Design: Retrospective cohort design.

Setting: Single institution, university hospital. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.04.002DOI Listing
December 2018
56 Reads

Postoperative complications as a predictor for survival after liver transplantation - proposition of a prognostic score.

HPB (Oxford) 2018 09 25;20(9):815-822. Epub 2018 Apr 25.

Department of Surgical Gastroenterology and Transplantation, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Background: Liver transplantation is major surgery with a high risk of complications. Existing scoring systems for evaluating complications after surgery are not specific for liver transplantation. Nor are they designed to evaluate the relation to recipient survival or graft loss. Read More

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http://dx.doi.org/10.1016/j.hpb.2018.03.001DOI Listing
September 2018
4 Reads

Risk Factors Associated With Peripheral Neuropathy in Heart Failure Patients Candidates for Transplantation.

Prog Transplant 2018 03;28(1):36-42

1 Cardiology Unit, Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy.

Introduction: Peripheral neuropathy can affect patients with heart failure, though its prevalence is unknown. After heart transplantation, it can influence the postoperative course and quality of life, but screening for neuromuscular disease is not routinely performed.

Objective: The aim of this study was to identify the factors associated with neuropathy in a population of patients with heart failure who are candidates for heart transplantation. Read More

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http://dx.doi.org/10.1177/1526924818765091DOI Listing
March 2018
30 Reads
0.686 Impact Factor

Intracranial Fungal Infection After Solid-Organ Transplant.

Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):179-182

Department of Neurosurgery, Baskent University Faculty of Medicine, Ankara, Turkey.

Neurologic complications after solid-organ transplant reveal a great spectrum of pathologies. Intracranial hemorrhages, cerebral ischemic lesions, infarctions, lymphoproliferative disorders, and infections, including aspergillosis, have been observed after liver transplant. Fungi constitute nearly 5% of all central nervous system infections, mainly occurring in immunocompromised patients. Read More

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http://dx.doi.org/10.6002/ect.TOND-TDTD2017.P56DOI Listing
March 2018
34 Reads

Complications of Liver Transplant in Adult Patients With the Hepatic Form of Wilson Disease.

Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):38-40

From the Department of Neurology, Başkent University, Ankara, Turkey.

Objectives: Wilson disease is an autosomal, recessive, inherited disorder of copper metabolism that results in the accumulation of copper in many organs and tissues. This disease is mainly characterized by dysfunction due to copper accumulation in the liver, kidney, brain, cornea, bone, heart, and blood cells. The clinical spectrum is broad in Wilson disease. Read More

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http://dx.doi.org/0.6002/ect.TOND-TDTD2017.O6DOI Listing
March 2018
9 Reads
0.798 Impact Factor

Neurologic Considerations and Complications Related to Liver Transplantation.

Anesthesiology 2018 05;128(5):1008-1014

From the Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1097/ALN.0000000000002148DOI Listing
May 2018
14 Reads
5.880 Impact Factor

Association between incision technique for hamstring tendon harvest in anterior cruciate ligament reconstruction and the risk of injury to the infra-patellar branch of the saphenous nerve: a meta-analysis.

Knee Surg Sports Traumatol Arthrosc 2018 Aug 8;26(8):2410-2423. Epub 2018 Feb 8.

Sicily Department, Rizzoli Orthopaedic Institute, Bagheria, Palermo, Italy.

Purpose: To determine how the incision technique for hamstring tendon (HT) harvest in anterior cruciate ligament (ACL) reconstruction affects the risk of injury to the IPBSN and clinical outcome.

Methods: A systematic literature search of the MEDLINE/Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL) and EBSCOhost electronic databases and clinicaltrials.gov for unpublished studies was performed to identify comparative studies investigating injury to the IPBSN after HT ACL reconstruction by comparing at least two different incision techniques. Read More

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http://dx.doi.org/10.1007/s00167-018-4858-xDOI Listing
August 2018
27 Reads

Incidence, risk factors, and outcomes related with neurological events after liver transplantation in adult and pediatric recipients.

Pediatr Transplant 2018 05 7;22(3):e13159. Epub 2018 Feb 7.

Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Universidad Austral, Pilar, Argentina.

Controversy exists whether NE after LT are more frequently observed in children or adults. We aimed to compare the incidence and outcomes for NE after LT in pediatric and adult recipients. A single-center cohort study, including all LT between 2001 and 2013, was performed. Read More

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http://dx.doi.org/10.1111/petr.13159DOI Listing
May 2018
74 Reads
1.630 Impact Factor

Therapeutic Plasma Exchange in Critically Ill Children Requiring Intensive Care.

Pediatr Crit Care Med 2018 02;19(2):e97-e104

Paediatric Intensive Care Unit, Royal Children's Hospital Melbourne, Australia.

Objective: To characterize the clinical indications, procedural safety, and outcome of critically ill children requiring therapeutic plasma exchange.

Design: Retrospective observational study based on a prospective registry.

Setting: Tertiary and quaternary referral 30-bed PICU. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001400DOI Listing
February 2018
21 Reads

Early stroke post-heart transplant is associated with decreased survival in children.

J Heart Lung Transplant 2018 06 9;37(6):733-739. Epub 2018 Jan 9.

Division of Pediatric Cardiology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address:

Background: Major neurologic events (MNEs) after heart transplantation (HTx) and their effect on survival have not been well described in children. In this study we aimed to characterize early MNEs (stroke, isolated seizures not from stroke and posterior reversible leukoencephalopathy [PRES] within 1 year after primary pediatric HTx) and evaluate their impact on 1-year post-HTx survival. We hypothesized that early an MNE after HTx is associated with decreased 1-year patient survival. Read More

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http://dx.doi.org/10.1016/j.healun.2017.12.016DOI Listing
June 2018
4 Reads

Assessing relative cost of complications following orthotopic liver transplant.

Clin Transplant 2018 Apr 14;32(4):e13209. Epub 2018 Feb 14.

Department of Surgery, University of Louisville, Louisville, KY, USA.

Introduction: Perioperative complications impose both a clinical and financial burden on patients and the healthcare system. This study sought to identify the frequency and economic impact of complications following orthotopic liver transplantation (OLT).

Methods: The Premier Perspective Hospital Database was queried for patients undergoing OLT between 2008 and 2015. Read More

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http://dx.doi.org/10.1111/ctr.13209DOI Listing
April 2018
5 Reads

Osmotic Shifts, Cerebral Edema, and Neurologic Deterioration in Severe Hepatic Encephalopathy.

Crit Care Med 2018 02;46(2):280-289

Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objectives: We sought to determine the effect of acute electrolyte and osmolar shifts on brain volume and neurologic function in patients with liver failure and severe hepatic encephalopathy.

Design: Retrospective analysis of brain CT scans and clinical data.

Setting: Tertiary care hospital ICUs. Read More

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http://dx.doi.org/10.1097/CCM.0000000000002831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774236PMC
February 2018
48 Reads

High Intrapatient Variability of Tacrolimus Exposure in the Early Period After Liver Transplantation Is Associated With Poorer Outcomes.

Transplantation 2018 03;102(3):e108-e114

INSERM, CIC 1414, Rennes, France.

Background: Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (IPV) on graft and patient outcomes after LT. Read More

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http://dx.doi.org/10.1097/TP.0000000000002052DOI Listing
March 2018
24 Reads
3.830 Impact Factor

Brain MRI findings in acute hepatic encephalopathy in liver transplant recipients.

Acta Neurol Belg 2018 Jun 23;118(2):251-258. Epub 2017 Dec 23.

Department of Nuclear Medicine, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, China.

Acute hepatic encephalopathy has significant morbidity and mortality in liver transplant recipients unless it is promptly treated. We evaluated the brain magnetic resonance (MR) imaging findings associated with acute hepatic encephalopathy in transplant recipients. We retrospectively reviewed the clinical and imaging data and outcomes of twenty-five liver transplant patients (16 male; mean age, 49. Read More

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http://dx.doi.org/10.1007/s13760-017-0875-7DOI Listing
June 2018
27 Reads

Chronic organ failure in adult sickle cell disease.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):435-439

UCSF Benioff Children's Hospital Oakland, Oakland, CA.

Sickle cell disease is now a chronic adult illness characterized by progressive multiorgan failure, particularly involving the brain and kidney. The etiology is multifactorial; it includes hemolysis and nitric oxide deficiency. As patients age, most experience neurologic insult. Read More

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http://dx.doi.org/10.1182/asheducation-2017.1.435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142529PMC
December 2017
17 Reads

Neurological development of children born to mothers after kidney transplantation.

J Matern Fetal Neonatal Med 2019 May 3;32(9):1523-1527. Epub 2017 Dec 3.

a Neonatology Ward, 1st Department of Obstetrics and Gynecology , Medical University of Warsaw , Warszawa , Poland.

Background: Pregnancies after kidney transplantation are at high risk of complications such as preterm birth and foetal growth restriction. Until now, the impact of these factors on neurological development of children born to transplant mothers has not been established.

Aims: A comparison of neurological examinations performed in 36 children of kidney transplant women (study group) and 36 children born to healthy mothers (control group). Read More

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http://dx.doi.org/10.1080/14767058.2017.1407754DOI Listing
May 2019
13 Reads

Progressive multifocal leukoencephalopathy - immune reconstitution inflammatory syndrome (PML-IRIS) in liver transplant recipient.

Mult Scler Relat Disord 2017 Oct 19;17:135-137. Epub 2017 Jul 19.

Clinical Radiology Institute, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia.

65-year-old liver transplant recipient presented with progressive neurologic dysfunction. CSF analysis revealed high JC virus load and MRI findings suggested the diagnosis of progressive multifocal leukoencephalopathy (PML). Cidofovir and mirtazapine were initiated and patient's regular immunosuppressants were reduced. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348173017
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http://dx.doi.org/10.1016/j.msard.2017.07.018DOI Listing
October 2017
33 Reads