2,325 results match your criteria Neurologic Complications of Organ Transplantation

[Laryngeal cancer surveillance in heart transplants].

Vestn Otorinolaringol 2020 ;85(6):34-36

Municipal Clinical Oncological Hospital No. 1, Moscow, Russia.

Transplantation of human internal organs is accompanied by the risk of the subsequent occurrence of a malignant neoplasm. The increased incidence of malignant neoplasms is due to immunosuppressive therapy, which leads to impaired immune surveillance for malignant neoplasms, as well as increased susceptibility to oncogenic viruses. We have not found a description of the laryngeal cancer development after heart transplantation in the available literature. Read More

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January 2021

Sarcopenia in Children With End-Stage Liver Disease on the Transplant Waiting List.

Liver Transpl 2021 05 27;27(5):641-651. Epub 2021 Feb 27.

Division of Gastroenterology, Hepatology, and Nutrition, the Hospital for Sick Children, Toronto, Ontario, Canada.

Sarcopenia predicts morbidity and mortality in adults with end-stage liver disease (ESLD) and is determined by total psoas muscle area (tPMA) measurement from computed tomography (CT) imaging. Recently developed pediatric age- and sex-specific tPMA growth curves provide the opportunity to ascertain prevalence and impact of sarcopenia in children awaiting liver transplantation (LT). This retrospective single-center study evaluated sarcopenia in children between 1 and 16 years with ESLD and a clinically indicated abdominal CT less than 3 months before first isolated LT. Read More

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Facial Paralysis From Post-transplant Lymphoproliferative Disorder.

Otol Neurotol 2021 06;42(5):e605-e608

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Objective: We report a case of facial paresis and profound hearing loss from post-transplant lymphoproliferative disorder (PTLD) in a pediatric patient with neuroblastoma.

Patient: Three-year-old boy with rapidly progressive right facial paresis and sensorineural hearing loss. High-risk neuroblastoma had been diagnosed 1 year earlier, treated with chemotherapy and resection of the adrenal primary tumor. Read More

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Complete recovery from COVID-19 of a kidney-pancreas transplant recipient: potential benefit from everolimus?

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia

We present a kidney-pancreas transplant recipient who achieved complete recovery from COVID-19. A 45-year-old patient with T3 paraplegia underwent kidney-pancreas transplantation 18 years ago, followed by a subsequent kidney transplant 9 years ago, and presented with fever, hypoxia and hypotension after exposure to two confirmed cases of COVID-19. History of solid organ transplant, pre-existing renal impairment, asthma and an elevated D-dimer were identified as established risk factors for severe COVID-19. Read More

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January 2021

Long-Term Survival and Causes of Death in Children with Trisomy 21 After Congenital Heart Surgery.

J Pediatr 2021 04 24;231:246-253.e3. Epub 2020 Dec 24.

Long Beach Memorial Heart and Vascular Institute, Long Beach, CA; Children's Heart Institute, MemorialCare Miller Children's and Women's Hospital, Long Beach, CA. Electronic address:

Objective: To evaluate long-term transplant-free survival and causes of death in the trisomy 21 (T21) population after surgery for congenital heart disease (CHD) in comparison with patients who are euploidic.

Study Design: This is a retrospective cohort study from the Pediatric Cardiac Care Consortium, enriched with prospectively collected data from the National Death Index and the Organ Procurement and Transplantation Network for patients with sufficient direct identifiers. Kaplan-Meier survival plots were generated and multivariable Cox proportional hazards models were used to examine risk factors for mortality between patients with T21 and 1:1 matched patients with comparable CHD who are euploidic. Read More

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Pearls & Oy-sters: Number, Weaker, and Dizzier Due to Transthyretin Amyloidosis After 2 Liver Transplants.

Neurology 2021 02 4;96(7):e1088-e1091. Epub 2020 Dec 4.

From the Ronald Reagan UCLA Medical Center, Los Angeles, CA.

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February 2021

Comparing Outcomes of Robotically Assisted Latissimus Dorsi Harvest to the Traditional Open Approach in Breast Reconstruction.

Plast Reconstr Surg 2020 12;146(6):1221-1225

From the Division of Plastic Surgery, Baylor College of Medicine; and the Department of Plastic Surgery, University of Texas M. D. Anderson Cancer.

Background: Robotically assisted latissimus dorsi harvest permits harvest of the latissimus dorsi muscle without a back incision, as compared to the traditional open technique. The authors hypothesized that robotic harvest has lower donor-site complication rates, decreased opioid requirements, and a shorter length of stay than the traditional open technique.

Methods: A retrospective review was performed of all consecutive pedicled latissimus dorsi flaps for breast reconstruction between 2011 and 2015. Read More

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December 2020

Sarcopenia Severity Based on Computed Tomography Image Analysis in Patients with Cirrhosis.

Nutrients 2020 Nov 11;12(11). Epub 2020 Nov 11.

Division of Gastroenterology & Liver Unit, University of Alberta, Edmonton, AB T6G 2X8, Canada.

Standardized sex-specific cut-offs for sarcopenia in cirrhosis are needed to identify the risk of clinical complications and to discriminate the severity of sarcopenia. We aimed to compare clinical characteristics between patients with cirrhosis categorized according to the severity of sarcopenia. Computed tomography images were taken at the 3rd lumbar vertebra from 603 patients with cirrhosis and 129 adult donors for living liver transplantation. Read More

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November 2020

Bacterial Pneumonia in Brain-Dead Patients: Clinical Features and Impact on Lung Suitability for Donation.

Crit Care Med 2020 12;48(12):1760-1770

Médecine Intensive et Réanimation, Centre Hospitalier Régional d'Orléans, Orléans, France.

Objectives: To appraise the epidemiological features of bacterial pneumonia and its impact on lung suitability for donation in brain-dead patients managed with protective ventilatory settings.

Design: Retrospective observational study.

Setting: Six ICUs from two university-affiliated hospitals. Read More

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December 2020

Graft factors as determinants of postoperative delirium after liver transplantation.

Updates Surg 2020 Dec 24;72(4):1053-1063. Epub 2020 Sep 24.

General Surgery 2U-Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Corso Bramante 88-90, 10126, Turin, Italy.

Post-operative delirium (POD) is a frequent complication after surgery, occurring in 15-20% of patients. POD is associated with a higher complications rate and mortality. Literature on POD after liver transplantation (LT) is limited, with the few available studies reporting an incidence of 10-47%. Read More

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December 2020

Antibody-negative autoimmune encephalitis as a complication of long-term immune-suppression for liver transplantation.

BMJ Case Rep 2020 Sep 15;13(9). Epub 2020 Sep 15.

Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, Kentucky, USA.

Autoimmune encephalitis is a rare spectrum of disease that can be a complication of chronic immunosuppression. Diagnosis often requires the presence of antineuronal antibodies, but many causative antibodies have not yet been identified. Antibody-negative autoimmune encephalitis (AbNAE) is especially difficult to diagnose and must rely largely on exclusion of other causes. Read More

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September 2020

Clinical Outcome in Human T-Lymphotropic Virus Type 2 Carriers Following Organ Transplantation.

Transplant Proc 2021 Mar 10;53(2):743-745. Epub 2020 Sep 10.

University International La Rioja Health Sciences School and Medical Center, Madrid, Spain. Electronic address:

Background: Frequent and rapid development of myelopathy has been reported in individuals with human T-lymphotropic virus type 1 (HTLV-1) infection following solid organ transplantation. There is no information regarding HTLV-2, a closely related virus that often infects injection drug users.

Methods: This study includes a retrospective analysis of all consecutive organ transplants performed during the last 2 decades at a large reference transplantation unit in Spain. Read More

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Clinical and Neurologic Outcomes in Acetaminophen-Induced Acute Liver Failure: A 21-Year Multicenter Cohort Study.

Clin Gastroenterol Hepatol 2020 Sep 10. Epub 2020 Sep 10.

Liver Unit, Division of Gastroenterology, Department of Critical Care Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background & Aims: Acetaminophen (APAP)-induced acute liver failure (ALF) is a rare disease associated with high mortality rates. This study aimed to evaluate changes in interventions, psychosocial profile, and clinical outcomes over a 21-year period using data from the ALF Study Group registry.

Methods: A retrospective review of this prospective, multicenter cohort study of all APAP-ALF patients enrolled during the study period (1998-2018) was completed. Read More

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September 2020

Inferior Meatus Mucosal Flap for Septal Reconstruction and Resurfacing After Nasoseptal Flap Harvest.

Laryngoscope 2021 05 1;131(5):952-955. Epub 2020 Sep 1.

Division of Otolaryngology/Head and Neck Surgery, Department of Surgery, Albany Medical Center, Albany, New York, U.S.A.

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[Early central neurologic complications after heart transplantation are associated with higher intra-hospital mortality].

Medicina (B Aires) 2020 ;80(4):324-328

Servicio de Neurología, Hospital Italiano de Buenos Aires, Argentina.

Neurological complications in orthotopic heart transplantation represent a major cause of morbidity and mortality despite successful transplantation. The aim of our study was to evaluate neurological complications on the outcome of patients with heart transplantation. We retrospectively studied 193 adult patients (aged = 18 years) who underwent heart transplant at Hospital Italiano in Buenos Aires from November 2014 to August 2018. Read More

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October 2020

Focused Update on Pulmonary Hypertension in Children-Selected Topics of Interest for the Adult Cardiologist.

Medicina (Kaunas) 2020 Aug 19;56(9). Epub 2020 Aug 19.

AKH-Vienna, Department of Cardiology, Medical University of Vienna, 1090 Wien, Austria.

Pulmonary hypertensive vascular disease (PHVD), and pulmonary hypertension (PH), which is a broader term, are severe conditions associated with high morbidity and mortality at all ages. Treatment guidelines in childhood are widely adopted from adult data and experience, though big differences may exist regarding aetiology, concomitant conditions and presentation. Over the past few years, paediatric aspects have been incorporated into the common guidelines, which currently address both children and adults with pulmonary hypertension (PH). Read More

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Predictors and outcomes of heart transplantation utilizing donors with different brain death mode: A propensity-score matching study from China.

Int J Cardiol 2021 01 15;322:58-64. Epub 2020 Aug 15.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address:

Background: Heart transplantation (HTx) of brain-dead donors in China has not been reported, not to mention analysis of donors with different brain death mechanisms. The present study aimed to compare clinical outcomes between HTx of traumatically brain-injured (TBI) and non-TBI donors, as well as to establish a risk-prediction model of mortality.

Methods: All patients undergoing HTx at our institute between January 1st, 2015 and December 31st, 2018 were dichotomized according to cause of donor death, and outcomes between the two groups were compared based on propensity score matching (PSM). Read More

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January 2021

The Challenges of Apnea Tests in the Determination of Brain Death in Child Patient on Extracorporeal Membrane Oxygenation.

Front Pediatr 2020 7;8:358. Epub 2020 Jul 7.

Department of Pediatric Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Extracorporeal membrane oxygenation (ECMO) is a life-support modality used in patients with refractory cardiac and/or respiratory failure. ECMO is linked with high risk of neurological complications including brain death. Neurological monitoring during ECMO is important for identifying patients who are suspected of brain death and allows to discontinue ineffective medical treatments. Read More

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Pretransplant Opioid Use and Survival After Lung Transplantation.

Transplantation 2020 08;104(8):1720-1725

Department of Medicine, University of Alberta, Edmonton, Canada.

Background: The impact of opioid use in lung transplant candidates on posttransplant outcomes is unknown. Studies on opioid therapy in kidney and liver transplant candidates have suggested increased risk of graft failure or death. We sought to analyze the relationship between pretransplant opioid use in lung transplant candidates and retransplant-free survival. Read More

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Successful Urgent Living Donor Liver Transplantation for Massive Liver Necrosis Accompanied by Nonocclusive Mesenteric Ischemia in a Biliary Atresia Infant: A Case Report.

Transplant Proc 2020 Nov 23;52(9):2802-2808. Epub 2020 Jul 23.

Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi Ward, Fukuoka, 812-8582, Japan; Pediatric Emergency and Critical Care Center, Kyushu University Hospital, 3-1-1 Maidashi, Higashi Ward, Fukuoka, 812-8582, Japan.

Background: Treatment options for patients presenting with life-threatening splanchnic ischemia, including that of the intestine and liver, could previously only receive salvage surgery and attempted medical revascularization. We propose that urgent liver transplantation (LT) for acute liver failure (ALF) due to massive liver necrosis should be considered as a life-saving treatment. We successfully performed urgent living donor LT for nonocclusive hepatic ischemia accompanied by nonocclusive mesenteric ischemia (NOMI). Read More

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November 2020

Facial Nerve Palsy Complicated by Masked Tuberculous Mastoiditis in a Recently Transplanted Patient.

Transplant Proc 2020 Nov 20;52(9):2747-2749. Epub 2020 Jul 20.

Centro de Neurologia, Guarapuava PR, Brazil.

Mastoiditis is a complication of the medium otitis characterized by suppuration and destruction of the mastoid cells and the pyramid petrosa; its tuberculous etiology has decreased in the last 40 years. Paralysis resulting from mastoiditis is more common in children. The incidence of mastoiditis has risen, although there are no reports in the literature associated with renal transplants. Read More

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November 2020

Clinical and molecular basis of hepatocerebral mitochondrial DNA depletion syndrome in Japan: evaluation of outcomes after liver transplantation.

Orphanet J Rare Dis 2020 07 24;15(1):169. Epub 2020 Jul 24.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, 579-1 Heta-cho, Midori-ku, Chiba, 266-0007, Japan.

Background: Hepatocerebral mitochondrial DNA depletion syndrome (MTDPS) is a disease caused by defects in mitochondrial DNA maintenance and leads to liver failure and neurological complications during infancy. Liver transplantation (LT) remains controversial due to poor outcomes associated with extrahepatic symptoms. The purposes of this study were to clarify the current clinical and molecular features of hepatocerebral MTDPS and to evaluate the outcomes of LT in MTDPS patients in Japan. Read More

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Timing of liver transplantation for pediatric acute liver failure due to mushroom poisoning: a case report and literature review.

BMC Pediatr 2020 07 23;20(1):351. Epub 2020 Jul 23.

Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, No. 1 Xinmin Street, 130021, Changchun, Jilin, China.

Background: Pediatric acute liver failure is a rare, life-threatening illness. Mushroom poisoning is a rare etiology. For patients with irreversible pediatric acute liver failure, liver transplantation is the ultimate lifesaving therapy. Read More

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Low C3 Serum Levels Predict Severe Forms of STEC-HUS With Neurologic Involvement.

Front Med (Lausanne) 2020 26;7:357. Epub 2020 Jun 26.

Unit of Pediatric Nephrology, University Hospital Policlinico Consorziale - Giovanni XXIII, Bari, Italy.

The correlation between the severity of hemolytic uremic syndrome related to Shiga toxin-producing (STEC-HUS) and involvement of the complement system has been examined in a small number of studies, with conflicting results. In the present study, we investigated whether serum C3 levels on admission are associated with neurologic involvement. To this purpose, 68 consecutive STEC-HUS patients were recruited and main clinical and laboratory variables ad hospital admission were compared between those with or without neurologic involvement. Read More

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Reversible posterior leukoencephalopathy syndrome due to adrenal pheochromocytoma: A case report and literature review.

Medicine (Baltimore) 2020 Jul;99(28):e20918

Department of Nephrology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Rationale: Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare neuropathic syndrome with typical clinical and radiological features. There are large amounts of risk factors resulting in RPLS, those including hypertension, eclampsia, neoplasia treatment, renal failure, systemic infections, chemotherapy, and immunosuppressive therapy after organ transplantation.

Patient Concerns: A 27-year-old male patient was admitted for a 2-week history of paroxysmal tic of limbs along with consciousness disorder. Read More

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Favorable Outcomes of Liver Transplantation from Controlled Circulatory Death Donors Using Normothermic Regional Perfusion Compared to Brain Death Donors.

Transplantation 2020 09;104(9):1943-1951

Service de Chirurgie Digestive, Hépato-Bilio-Pancréatique et Transplantation Hépatique, Pitié-Salpêtrière, AP HP, Sorbonne Université, Paris, France.

Background: Liver transplantation (LT) from controlled donation after circulatory death (cDCD) was initiated in France in 2015 under a protocol based on the use of normothermic regional perfusion (NRP) before organ procurement. The aim was to compare outcomes following cDCD LT with NRP and donation after brain death (DBD) LT.

Methods: This is a multicenter retrospective study comparing cDCD LT with NRP and DBD LT. Read More

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September 2020

Acute and reversible Pisa syndrome as unusual presentation of portosystemic encephalopathy.

Clin Neurol Neurosurg 2020 09 23;196:106040. Epub 2020 Jun 23.

Neurology Service, Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione (IRCCS-ISMETT) Via Ernesto Tricomi 5, 90127, Palermo, Italy. Electronic address:

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September 2020

Tacrolimus and Mycophenolic Acid Blood Concentration and Cellular Rejection After Heart Transplantation in First Endomyocardial Biopsy.

Transplant Proc 2020 Sep 20;52(7):2094-2097. Epub 2020 Jun 20.

Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Silesian Centre for Heart Diseases, Medical University of Silesia, Zabrze, Poland; General Surgery, Medical College, Jagiellonian University, Cracow, Poland.

Background: Tacrolimus and mycophenolic acid (MPA) are the most important immunosuppressive drugs in modern heart transplantation. The pharmacokinetics of tacrolimus are best described by a 2-compartment model. MPA has very variable pharmacokinetics. Read More

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September 2020

Body Mass Index as a Prognostic Factor in Liver Transplantation.

Transplant Proc 2020 Jun 10;52(5):1493-1495. Epub 2020 May 10.

Section of Hepatobiliary Surgery and Liver Transplantation, Department of General Surgery, Virgen del Rocio University Hospital, Sevilla, Spain.

Objective: Obesity is one of the main growing epidemics of the last century and is responsible for many deaths worldwide. The aim of this study is to analyze the impact of the body mass index (BMI) of the recipient on survival and morbidity after liver transplantation (LT).

Material And Methods: We conducted a retrospective cohort study of all transplanted recipients in a third-level hospital between 2006 and 2018. Read More

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Spinal Cord Ischemia Because of Microvascular Thrombosis in a Patient with Necrotizing Pancreatitis. Case Report and Literature Review.

Am J Case Rep 2020 May 12;21:e923273. Epub 2020 May 12.

Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND Central nervous system ischemia in acute pancreatitis is rare with only a handful of cases reported in the literature. We report a case of spinal cord ischemia due to microvascular thrombosis complicating acute on chronic pancreatitis. CASE REPORT A 37-year-old male was transferred to a university hospital intensive care unit with a diagnosis of acute onset chronic pancreatitis, paraplegia, and multi-organ failure. Read More

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