3,538 results match your criteria Neurologic Complications of Organ Transplantation


Effects of polyethylene glycol-20k IV solution on donor management in a canine model of donor brain death.

Biomed Pharmacother 2022 Aug 14;152:113293. Epub 2022 Jun 14.

Departments of Surgery Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA; Emergency Medicine Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA; Physiology and Biophysics Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA. Electronic address:

Background: Traditionally, vasopressors and crystalloids have been used to stabilize brain dead donors; however, the use of crystalloid is fraught with complications. This study aimed to investigate the effectiveness of a newly developed impermeant solution, polyethylene glycol-20k IV solution (PEG-20k) for resuscitation and support of brain dead organ donors.

Methods: Brain death was induced in adult beagle dogs and a set volume of PEG-20k or crystalloid solution was given thereafter. Read More

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Zoster paresis in a renal transplant patient: preliminary considerations.

BMJ Case Rep 2022 06 6;15(6). Epub 2022 Jun 6.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Left Paraduodenal Hernia in a Young Patient with Recurrent Abdominal Pain: A Case Report and Short Literature Review.

Am J Case Rep 2022 Jun 4;23:e935413. Epub 2022 Jun 4.

Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.

BACKGROUND Internal hernias are a rare cause of small bowel obstruction in patients, which usually have a long history of mild abdominal symptoms, sometimes leading to emergency surgery due to acute abdominal pain. Occasionally, it takes a long time to make the correct diagnosis because of symptoms vagueness and transience of typical imaging findings; at times, a definitive diagnosis is possible only through surgery, especially in cases of acute presentations in a low-resource setting where high-performance diagnostic equipment may be unavailable. CASE REPORT We report the case of a young male patient with a long history of mild abdominal symptoms and some episodes of acute abdominal pain. Read More

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Impaired Vagal Activity in Long-COVID-19 Patients.

Viruses 2022 05 13;14(5). Epub 2022 May 13.

Department of Internal Medicine, San Francesco Hospital, Viale Europa 21, 82037 Telese Terme, Italy.

Long-COVID-19 refers to the signs and symptoms that continue or develop after the "acute COVID-19" phase. These patients have an increased risk of multiorgan dysfunction, readmission, and mortality. In Long-COVID-19 patients, it is possible to detect a persistent increase in D-Dimer, NT-ProBNP, and autonomic nervous system dysfunction. Read More

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Superior Laryngeal Nerve Block Attenuates Refractory Cough in a Patient With COVID-19 on Extracorporeal Membrane Oxygenation Awaiting Lung Transplantation.

J Cardiothorac Vasc Anesth 2022 Aug 22;36(8 Pt B):3212-3215. Epub 2022 Apr 22.

Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston, SC.

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Heart Transplantation in Children With Down Syndrome.

J Am Heart Assoc 2022 May 16;11(10):e024883. Epub 2022 May 16.

Division of Pediatric Cardiology Stanford University Palo Alto CA.

Background Children with Down syndrome (DS) have a high risk of cardiac disease that may prompt consideration for heart transplantation (HTx). However, transplantation in patients with DS is rarely reported. This project aimed to collect and describe waitlist and post- HTx outcomes in children with DS. Read More

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Normothermic Regional Perfusion and Hypothermic Oxygenated Machine Perfusion for Livers Donated After Controlled Circulatory Death With Prolonged Warm Ischemia Time: A Matched Comparison With Livers From Brain-Dead Donors.

Transpl Int 2022 22;35:10390. Epub 2022 Apr 22.

General Surgery 2U-Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

Prolonged warm ischemia time (WIT) has a negative prognostic value in liver transplantation (LT) using grafts procured after circulatory death (DCD). To assess the value of abdominal normothermic regional perfusion (A-NRP) associated with dual hypothermic oxygenated machine perfusion (D-HOPE) in controlled DCD LT, prospectively collected data on LTs performed between January 2016 and July 2021 were analyzed. Outcome of controlled DCD LTs performed using A-NRP + D-HOPE ( = 20) were compared to those performed with grafts procured after brain death (DBD) ( = 40), selected using propensity-score matching. Read More

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Headache in Pediatric and Adolescent Patients With Chronic Kidney Disease and After Kidney Transplantation: A Comparative Study.

J Child Neurol 2022 May 26;37(6):497-504. Epub 2022 Apr 26.

Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's Medical Center of Israel and Sackler Faculty of Medicine, 58408Tel Aviv University, Tel Aviv, Israel.

Aim: This study compared prevalence and characteristics of headaches between pediatric patients with chronic kidney disease and pediatric patients with transplanted kidneys and identify factors associated with headaches in the entire cohort.

Methods: We interviewed 87 children and adolescents with either chronic kidney disease or transplanted kidney, regarding the prevalence of headaches and their characteristics. We reviewed hospital charts for medical history and blood test. Read More

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Clinical Profile of Central Nervous System Involvement in Patients with Rhino Orbital Cerebral Mucormycosis.

J Assoc Physicians India 2022 Apr;70(4):11-12

Bangalore Medical College, Kalaburgi.

Mucormycosis is life threatening fungal infection that occurs in immunocompromised patients. Patients at risk are those with poorly controlled diabetes mellitus, immunosuppressed patients such as those undergoing treatment for hematological cancer or recipients of solid organ and hematopoietic stem cell transplantation. COVID 19 infection is known to produce a state of hyper inflammation with release of various cytokines this state of immune dysfunction is associated with development of opportunistic infections, of which Mucormycosis is on the rise currently. Read More

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Globi pallidi injury not caused by manganese in cirrhosis of Alagille syndrome.

Pediatr Int 2022 01;64(1):e15088

Division of Neurology, National Center for Child Health and Development, Tokyo, Japan.

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January 2022

High-dose preoperative glucocorticoid for prevention of emergence and postoperative delirium in liver resection: A double-blinded randomized clinical trial substudy.

Acta Anaesthesiol Scand 2022 Jul 11;66(6):696-703. Epub 2022 Apr 11.

Department of Anesthesiology, Centre for Cancer and Organ Diseases, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.

Background: Emergence delirium (ED) and postoperative delirium (POD) are associated with increased morbidity and mortality and occur in up to one-third of patients undergoing major non-cardiac surgery, where the underlying pathogenesis is multifactorial, including increased inflammation. We aimed to assess the effect of pre-operative high- versus low-dose glucocorticoid on the occurrence of ED and POD.

Methods: This was a substudy from a randomized, double-blinded clinical trial. Read More

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Trends and Outcomes of Left Ventricular Assist Device Therapy: JACC Focus Seminar.

J Am Coll Cardiol 2022 03;79(11):1092-1107

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

As the prevalence of advanced heart failure continues to rise, treatment strategies for select patients include heart transplantation or durable left ventricular assist device (LVAD) support, both of which improve quality of life and extend survival. Recently, the HeartMate 3 has been incorporated into clinical practice, the United Network for Organ Sharing donor heart allocation system was revised, and the management of LVAD-related complications has evolved. Contemporary LVAD recipients have greater preoperative illness severity, but survival is higher and adverse event rates are lower compared with prior eras. Read More

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Advances in the diagnosis and treatment of sickle cell disease.

J Hematol Oncol 2022 03 3;15(1):20. Epub 2022 Mar 3.

Division of Hematology, Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Sickle cell disease (SCD), which affects approximately 100,000 individuals in the USA and more than 3 million worldwide, is caused by mutations in the βb globin gene that result in sickle hemoglobin production. Sickle hemoglobin polymerization leads to red blood cell sickling, chronic hemolysis and vaso-occlusion. Acute and chronic pain as well as end-organ damage occur throughout the lifespan of individuals living with SCD resulting in significant disease morbidity and a median life expectancy of 43 years in the USA. Read More

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The Spectrum of Malignant Neoplasms among Liver Transplant Recipients: Sociodemographic Factors, Mortality, and Hospital Burden.

Int J Med Sci 2022 9;19(2):299-309. Epub 2022 Jan 9.

Department of Internal Medicine, Detroit Medical Center/Wayne State University-Sinai Grace Hospital, Detroit, USA.

To determine the nationwide prevalence of malignant neoplasms (excluding hepatocellular carcinoma-HCC) in hospitalized liver transplant recipients and to study the hospital utilization, and mortality to the incidence of malignancies. To the best of our knowledge, few epidemiological studies addressed outcomes in post-liver transplant patients, such as the annual number of hospitalizations, mortality, patient characteristics regarding malignancies. NIS database was queried between 2016 and 2018 to retrieve records of patients admitted with a principal or secondary diagnosis of liver transplant following . Read More

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Outcome of liver transplantation with grafts from brain-dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors.

Am J Transplant 2022 05 22;22(5):1382-1395. Epub 2022 Feb 22.

General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

Prompted by the utilization of extended criteria donors, dual hypothermic oxygenated machine perfusion (D-HOPE) was introduced in liver transplantation to improve preservation. When donors after neurological determination of death (DBD) are used, D-HOPE effect on graft outcomes is unclear. To assess D-HOPE value in this setting and to identify ideal scenarios for its use, data on primary adult liver transplant recipients from January 2014 to April 2021 were analyzed using inverse probability of treatment weighting, comparing outcomes of D-HOPE-treated grafts (n = 121) with those preserved by static cold storage (n = 723). Read More

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Bilateral Quadriceps Tendon Rupture and Femoral Neck Fracture After Generalized Tonic-Clonic Seizures: A Case Report.

JBJS Case Connect 2022 02 10;12(1). Epub 2022 Feb 10.

Trauma Department, Hannover Medical School (MHH), Hannover, Germany.

Case: We report on a 19-year-old male renal transplant patient with multiple medical issues who sustained simultaneous bilateral quadriceps tendon ruptures and bilateral femoral neck fractures after 2 generalized tonic-clonic seizures. The quadriceps tendon ruptures were detected early surgically repaired; the femoral neck fractures were not detected and managed with bilateral total hip arthroplasty for almost 2 weeks.

Conclusion: Tonic-clonic seizures can be associated with unique and complex acute orthopaedic injuries that can be initially missed. Read More

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February 2022

Immunosuppressive drugs and associated complications in abdominal organ transplantation.

Authors:
Jody C Olson

Curr Opin Crit Care 2022 04;28(2):208-215

Transplant Hepatology and Critical Care Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Purpose Of Review: Intensive care management of patients who have undergone organ transplantation of liver, small bowel, pancreas, and/or kidney requires a basic knowledge of immunosuppression principles and the management of immunosuppressive medications. This review highlights the core principles of immunosuppression management in abdominal organ transplantation with a focus on complications arising from immunosuppressive drugs, both in the immediate postoperative period and in long-term usage.

Recent Findings: The general principles of management of immunosuppression in the abdominal organ transplant population have remained largely unchanged. Read More

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Seizures in a Child Post Renal Transplant: A Case of Disequilibrium Syndrome.

Saudi J Kidney Dis Transpl 2021 May-Jun;32(3):861-864

Division of Nephrology, Hamid Al-Essa Organ Transplant Center, Sabah Health Region, Shuwaikh, Kuwait.

Disequilibrium syndrome is typically characterized by neurological manifestations that occur acutely posthemodialysis due to a significant drop in serum osmolality. We report a child with disequilibrium syndrome postrenal transplant and compare this presentation to previously reported cases. Read More

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February 2022

Efficacy and safety of perioperative vitamin C in patients undergoing noncardiac surgery: a systematic review and meta-analysis of randomised trials.

Br J Anaesth 2022 Apr 26;128(4):664-678. Epub 2022 Jan 26.

Division of Anaesthesiology, Department of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland. Electronic address:

Background: Perioperative oxidative stress plays a role in organ injury and pain and could be improved by the antioxidant effects of vitamin C.

Methods: We performed a systematic review and meta-analysis of RCTs comparing perioperative vitamin C administration vs placebo or no treatment in adults undergoing noncardiac surgery. The primary outcome was hospital length of stay (LOS). Read More

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Liver allograft findings of donation after cardiac death versus brain death in recipients with hepatitis C related cirrhosis: a matched histologic comparison.

Hum Pathol 2022 04 25;122:25-31. Epub 2022 Jan 25.

Yale University, School of Medicine, New Haven, CT 06510, USA. Electronic address:

As the demand for organ transplantation increases, utilization of liver allografts of donation after cardiac death (DCD) is becoming increasingly necessary. Although the clinical outcomes of DCD allografts have been well described, the histologic features are not well characterized. Liver biopsies (n = 131) from age-matched DCD (n = 60) and donation after brain death (DBD; n = 71) recipients with hepatitis C virus were compared. Read More

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Long-Term Outcome After Tacrolimus-Related Neurotoxicity in Pediatric Living Donor Liver Transplantation.

Transplant Proc 2022 Mar 21;54(2):468-471. Epub 2022 Jan 21.

Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Background: Tacrolimus-related neurotoxicity is a serious complication. Posterior reversible encephalopathy syndrome, which is severe neurotoxicity after pediatric living donor liver transplantation (LDLT), is a medication-induced complication related to calcineurin inhibitors. The purpose of this study was to evaluate the long-term outcome of tacrolimus-related neurotoxicity after pediatric LDLT. Read More

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Impact of pretransplant frailty and sarcopenia on the post-transplant prognosis of patients with liver cirrhosis: a systematic review.

Eur J Gastroenterol Hepatol 2021 12;33(1S Suppl 1):e883-e897

Clínica Universitária de Gastrenterologia, Faculdade de Medicina, Universidade de Lisboa.

Introduction: Frailty and sarcopenia associate with increased mortality in patients with liver cirrhosis on the transplant waitlist. We conducted a systematic review on the impact of pretransplant frailty and sarcopenia on post-transplant outcomes in adult patients with liver cirrhosis.

Methods: We performed a search in Medline, Embase and Cochrane Central. Read More

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December 2021

West nile virus infection: One-Year postkidney transplant.

Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):532-542

Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman.

West Nile virus (WNV) infections are a mosquito-borne virus of the Flaviviridae family. The clinical feature of the virus varies between individuals from being asymptomatic in most of the cases to severe central nervous system disease manifested as meningitis, encephalitis, and paralysis. Diabetic nephropathy patient with microvascular and macrovascular complications, who received a kidney transplant a year ago on immunosuppressive therapy, presented with a three-day history of upper respiratory tract infection and fever. Read More

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February 2022

Posttransplant lymphoproliferative disorder in renal transplant recipients: Experience from a Tertiary Care Center.

Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):418-427

Department of Laboratory Science and Molecular Medicine, Army Hospital (Research and Referral), New Delhi, India.

Posttransplant lymphoproliferative disorders (PTLDs) are potentially fatal complications arising after solid organ or hematopoietic stem cell transplant. The most crucial factor in pathogenesis of PTLDs is either a primary infection with Epstein-Barr virus or reactivation of its latent state due to immune dysregulation. This complex pathobiology leads to a myriad of clinical manifestations due to uncontrolled lymphoproliferation that may be reactive, polymorphous or monomorphous. Read More

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February 2022

Caution Regarding Endoscopic Balloon Placement and the Risk of Sarcopenia in Liver Transplant Candidates.

Liver Transpl 2022 04 27;28(4):730-731. Epub 2022 Jan 27.

Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australia.

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CNS Post-Transplant Lymphoproliferative Disorder in a Heart Recipient: A Case Report.

Int J Organ Transplant Med 2021 ;12(2):46-49

Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Solid organ recipients have increased risk of malignancy in comparison with general population. Although post-transplant lymphoproliferative disorders are the second most common cancer in transplanted patients, primary CNS lymphoma is a rare presentation of these disorders. Among the wide range of neurologic complications in post- transplant period, some characteristics could be helpful for diagnosing of this disorder. Read More

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January 2021

Emerging Patient-Centered Concepts in Pain Among Adults With Chronic Kidney Disease, Maintenance Dialysis, and Kidney Transplant.

Semin Nephrol 2021 11;41(6):550-562

Department of Internal Medicine, University of Illinois Hospital and Health Sciences Center, Chicago, IL; Renal Section, Medical Service, Jesse Brown VA Medical Center, Chicago, IL; Center of Innovation for Complex Chronic Health Care, Edward Hines, Jr. VA Hospital, Hines, IL.

Patient reports of moderate to severe pain are common across the spectrum of chronic kidney disease. The synergistic effects of comorbid depression and anxiety can lead to maladaptive coping responses to pain, namely pain catastrophizing and illness-related post-traumatic stress disorder. If underlying depression and anxiety and associated maladaptive coping responses are not treated, patients can experience an increased perception of pain, worsened disability, decreased quality of life, withdrawal from social activities, and increased morbidity and mortality. Read More

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November 2021

Liver Transplantation Reverses Hepatic Myelopathy in Hepatitis B-Related Decompensated Liver Cirrhosis: Case Report and Review of the Literature.

Transplant Proc 2022 Jan-Feb;54(1):158-160. Epub 2021 Dec 24.

Department of Organ Transplantation Center, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China. Electronic address:

Severe neurologic complications after chronic liver disease greatly affect the patient's quality of life. Hepatic myelopathy (HM) is a rare but devastating disease, in chronic liver disease. The limbs of patients with HM show slowly progressive symmetrical spastic paralysis without sensory loss. Read More

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February 2022

Granulocyte Colony-Stimulating Factor Is Safe and Well Tolerated following Allogeneic Transplantation in Patients with Sickle Cell Disease.

Transplant Cell Ther 2022 03 24;28(3):174.e1-174.e5. Epub 2021 Dec 24.

Division of Pediatric Hematology Oncology, Washington University, St. Louis, Missouri.

Granulocyte colony-stimulating factor (G-CSF) used after hematopoietic stem cell transplantation (HSCT) can enhance neutrophil recovery in patients rendered neutropenic by the preparative regimen. G-CSF is contraindicated in patients with sickle cell disease (SCD), because life-threatening complications can ensue in the presence of sickle vasculopathy. The safety profile of G-CSF after HSCT for SCD has not been described, however. Read More

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Outcome of Liver Transplants Using Donors After Cardiac Death With Normothermic Regional Perfusion.

Transplant Proc 2022 Jan-Feb;54(1):37-40. Epub 2021 Dec 23.

Department of Hepatic Surgery and Transplants, Hospital Regional Universitario, Málaga, Spain; Faculty of Medicine, University of Malaga, Malaga, Spain.

Background And Aims: The incorporation of normothermic regional perfusion (NRP) to donors after cardiac death (DCD) allows the recovery of liver grafts without the deleterious effects on graft survival the super-rapid technique may cause. The aim of the present report is to determine if the use of NRP in Maastricht type III DCD donors achieves short- and medium-term results comparable to donors after brain death (DBD).

Patients And Methods: This is an observational cohort study including 117 liver transplants executed between November 2016 and April 2021, divided into NRP (n = 39) and DBD (n = 78). Read More

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February 2022