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    509 results match your criteria Neurologic Complications of Organ Transplantation

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    Imaging spectrum of central nervous system complications of hematopoietic stem cell and solid organ transplantation.
    Neuroradiology 2017 Feb 2;59(2):105-126. Epub 2017 Mar 2.
    Section of Neuroradiology, Department of Radiology and Nuclear Medicine, Oslo University Hospital-Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.
    Neurologic complications are common after hematopoietic stem cell transplantation (HSCT) and solid organ transplantation (SOT) and affect 30-60% of transplant recipients. The aim of this article is to provide a practical imaging approach based on the timeline and etiology of CNS abnormalities, and neurologic complications related to transplantation of specific organs. The lesions will be classified based upon the interval from HSCT procedure: pre-engraftment period <30 days, early post-engraftment period 30-100 days, late post-engraftment period >100 days, and the interval from SOT procedure: postoperative phase 1-4 weeks, early posttransplant syndromes 1-6 months, late posttransplant syndromes >6 months. Read More

    Neurologic Complications of Transplantation.
    Neurocrit Care 2017 Mar 1. Epub 2017 Mar 1.
    Department of Neurology (Division of Neurocritical Care), Washington University in St. Louis School of Medicine, 660 S Euclid Avenue, Campus Box 8111, Saint Louis, MO, 63110, USA.
    Neurologic disturbances including encephalopathy, seizures, and focal deficits complicate the course 10-30% of patients undergoing organ or stem cell transplantation. While much or this morbidity is multifactorial and often associated with extra-cerebral dysfunction (e.g. Read More

    Neurologic complications of transplantation.
    Handb Clin Neurol 2017 ;141:545-572
    Division of Neurocritical Care, Department of Neurology, Washington University, St. Louis, MO, USA. Electronic address:
    Major neurologic morbidity, such as seizures and encephalopathy, complicates 20-30% of organ and stem cell transplantation procedures. The majority of these disorders occur in the early posttransplant period, but recipients remain at risk for opportunistic infections and other nervous system disorders for many years. These long-term risks may be increasing as acute survival increases, and a greater number of "sicker" patients are exposed to long-term immunosuppression. Read More

    Clinical Characteristics of Transplant-associated Encephalopathy in Children.
    J Korean Med Sci 2017 Mar;32(3):457-464
    Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
    We aimed to analyze characteristics of encephalopathy after both hematopoietic stem cell and solid organ pediatric transplantation. We retrospectively reviewed medical records of 662 pediatric transplant recipients (201 with liver transplantation [LT], 55 with heart transplantation [HT], and 67 with kidney transplantation [KT], 339 with allogeneic hematopoietic stem cell transplantation [HSCT]) who received their graft organs at Asan Medical Center between January 2000 and July 2014. Of the 662 patients, 50 (7. Read More

    Early and late neurological complications of liver transplantation in pediatric patients.
    Pediatr Transplant 2017 May 1;21(3). Epub 2017 Jan 1.
    Department of Surgery, Faculty of Medicine, İnönü University, Malatya, Turkey.
    NCs occur commonly after solid organ transplantation and affect 15%-30% of liver transplant recipients. The aim of this retrospective study was to evaluate the type and incidence of neurologic events in pediatric patients following LT. Between May 2006 and June 2015, 242 patients (118 females, 124 males) requiring LT for different etiologies at the İnönü University Liver Transplantation Institute were included. Read More

    Gangliocytoma Presenting With Tacrolimus Neurotoxicity in a Renal Transplant Recipient: Case Report.
    Transplant Proc 2016 Nov;48(9):3142-3144
    Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address:
    Tacrolimus is a widely used macrolide immunosuppressant in transplant surgery, with mild and major neurologic side effects. A 21-year-old woman had undergone preemptive transplantation of a kidney from her mother. On the 1st postoperative day, the patient had headache, nausea, vomiting, and agitation. Read More

    Venoarterial Extracorporeal Membrane Oxygenation Support as a Bridge to Heart Transplant: Report of 3 Cases.
    Exp Clin Transplant 2016 11;14(Suppl 3):121-124
    From the Department of Anesthesiology and Critical Care Medicine Faculty of Medicine, Baskent University Ankara, Turkey.
    Heart transplant is the only definitive treatment of end-stage heart failure. Venoarterial extracorporeal membrane oxygenation may be used as a bridge to heart transplant. Among 31 patients who underwent heart transplant between January 2014 and June 2016, we present our experiences with 3 patients who received venoarterial extracorporeal support as a bridge to heart transplant. Read More

    Partners in Crime: Kidney Transplantation and Seizure Disorder.
    Transplant Proc 2016 Oct;48(8):2700-2708
    Section of Transplantation and Immunology, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address:
    Seizure disorder is a common neurologic complication of kidney transplantation and often presents as a complex management challenge. Little is known about the risks mutually conferred by the 2 clinical entities and the effects of such risks on clinical outcomes. Using the National Inpatient Sample, our goal was to examine the effects of kidney transplantation and seizure disorder on mortality, hospitalization statistics, clinical complications, and cost of care. Read More

    Acute West Nile Virus Meningoencephalitis Diagnosed Via Metagenomic Deep Sequencing of Cerebrospinal Fluid in a Renal Transplant Patient.
    Am J Transplant 2017 Mar 21;17(3):803-808. Epub 2016 Oct 21.
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA.
    Solid organ transplant patients are vulnerable to suffering neurologic complications from a wide array of viral infections and can be sentinels in the population who are first to get serious complications from emerging infections like the recent waves of arboviruses, including West Nile virus, Chikungunya virus, Zika virus, and Dengue virus. The diverse and rapidly changing landscape of possible causes of viral encephalitis poses great challenges for traditional candidate-based infectious disease diagnostics that already fail to identify a causative pathogen in approximately 50% of encephalitis cases. We present the case of a 14-year-old girl on immunosuppression for a renal transplant who presented with acute meningoencephalitis. Read More

    [Allogeneic hematopoietic stem cell transplantation associated thrombotic microangiopathy: 16 cases report and literature review].
    Zhonghua Xue Ye Xue Za Zhi 2016 Aug;37(8):666-70
    The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
    Objective: To analyze the clinical characteristics, treatment and prognosis of 16 allogeneic hematopoietic stem cell transplantation (allo- HSCT)- associated thrombotic microangiopathy (TA- TMA) patients.

    Methods: The clinical data of 16 TA- TMA cases in 852 patients following allo- HSCT from Jan. 2013 to Jun. Read More


    Mechanical Circulatory Support as Bridge to Transplantation for the Failing Single Ventricle.
    Ann Thorac Surg 2017 Jan 15;103(1):193-197. Epub 2016 Jul 15.
    Department of Cardiac Surgery, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Circulatory failure necessitating cardiac transplantation will ultimately develop in many patients with functional single-ventricle physiology. Interest in the use of mechanical circulatory support (MCS) in this population is growing.

    Methods: This was a retrospective case series of patients with functional single-ventricle physiology who underwent MCS with a ventricular assist device or a total artificial heart as a bridge to cardiac transplantation between January 2006 and December 2014. Read More

    Comprehensive risk assessment for early neurologic complications after liver transplantation.
    World J Gastroenterol 2016 Jun;22(24):5548-57
    Si-Yuan Wu, Teng-Wei Chen, An-Chieh Feng, Hsiu-Lung Fan, Chung-Bao Hsieh, Division of Organ Transplantation Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
    Aim: To determine risk factors for early neurologic complications (NCs) after liver transplantation from perspective of recipient, donor, and surgeon.

    Methods: In all, 295 adult recipients were enrolled consecutively between August 2001 and February 2014 from a single medical center in Taiwan. Any NC in the first 30 d post-liver transplantation, and perioperative variables from multiple perspectives were collected and analyzed. Read More

    Five-Year Clinical Outcome of Endoscopic Versus Open Radial Artery Harvesting: A Propensity Score Analysis.
    Ann Thorac Surg 2016 Oct 16;102(4):1253-9. Epub 2016 Jun 16.
    Division of Cardiac Surgery, University of Brescia Medical School, Brescia, Italy.
    Background: Despite the popularity of less invasive approaches for conduits procurement in coronary artery bypass graft surgery, concerns have been raised about the potential detrimental effects of the endoscopic technique when compared with the conventional "open" technique.

    Methods: Among 470 patients undergoing coronary surgery with the use of a radial artery conduit, a propensity score analysis was performed among those patients assigned either to an open technique (n = 82) or to an endoscopic approach (n = 82). Endoscopic harvesting was performed with a nonsealed system. Read More

    Prolonged Intraoperative Cardiac Resuscitation Complicated by Intracardiac Thrombus in a Patient Undergoing Orthotopic Liver Transplantation.
    Semin Cardiothorac Vasc Anesth 2016 Sep 26;20(3):246-51. Epub 2016 May 26.
    Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    We report the case of successful resuscitation after prolonged cardiac arrest during orthotopic liver transplantation. After reperfusion, the patient developed ventricular tachycardia, complicated by intracardiac clot formation and massive hemorrhage. Transesophageal echocardiography demonstrated stunned and nonfunctioning right and left ventricles, with developing intracardiac clots. Read More

    Diagnosis and Management of Sarcoidosis.
    Am Fam Physician 2016 May;93(10):840-8
    University of Texas Health Science Center, San Antonio, TX, USA.
    Sarcoidosis is a systemic disease of unknown etiology characterized by the presence of noncaseating granulomas in any organ, most commonly the lungs and intrathoracic lymph nodes. A diagnosis of sarcoidosis should be suspected in any young or middle-aged adult presenting with unexplained cough, shortness of breath, or constitutional symptoms, especially among blacks or Scandinavians. Diagnosis relies on three criteria: (1) a compatible clinical and radiologic presentation, (2) pathologic evidence of noncaseating granulomas, and (3) exclusion of other diseases with similar findings, such as infections or malignancy. Read More

    [Analysis of complications in 61 extracorporeal membrane oxygenation cases].
    Zhonghua Wai Ke Za Zhi 2016 May;54(5):384-8
    Department of Cardiopulmonary Bypass, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China.
    Objective: To analyze the reason and treatment of the complications of 61 cases of extracorporeal membrane oxygenation (ECMO) in order to improve survival rate of ECMO treatment.

    Methods: ECMO records from January 2007 to December 2014 in Shanghai Chest Hospital were investigated retrospectively focusing on complications. There were included 43 male and 18 female patients, age 3 to 66 years. Read More

    Calcineurin Inhibitors Associated Posterior Reversible Encephalopathy Syndrome in Solid Organ Transplantation: Report of 2 Cases and Literature Review.
    Medicine (Baltimore) 2016 Apr;95(14):e3173
    From the Department of Urology, Institute of Urology, Organ Transplantation Center (TS, ZR, YQ, JL, ZH, XW, TL); and The Third Comprehensive Care Unit, West China Hospital, Sichuan University (QT), Chengdu, Sichuan, China.
    Posterior reversible encephalopathy syndrome (PRES) is a rare neurologic side effect of calcineurin inhibitors (CNIs) with poorly understood clinical features.We report cases of 2 patients with PRES developing after kidney transplantation and summarize PRES clinical features through a literature review.The 1st case was a 28-year-old man who received a kidney transplant from a deceased donor. Read More

    Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a woman with systemic lupus erythematosus.
    J Clin Neurosci 2016 Jul 17;29:194-6. Epub 2016 Feb 17.
    Rush University Medical Center, 1750 W Harrison Street, Ste 570 Jelke, Chicago, IL 60661, USA.
    Classic cerebral toxoplasmosis typically presents with neurologic symptoms such as seizures and mental status changes and histological examination shows focal lesions with necrosis. However, in the diffuse "encephalitic" form, patients are asymptomatic with diffuse, inflammatory, non-necrotic lesions. Asymptomatic diffuse "encephalitic" toxoplasmosis has been reported only in four acquired immunodeficiency syndrome patients and one human immunodeficiency virus (HIV) negative patient with chronic lymphocytic leukemia. Read More

    Lung Quality and Utilization in Controlled Donation After Circulatory Determination of Death Within the United States.
    Am J Transplant 2016 Apr 4;16(4):1207-15. Epub 2016 Feb 4.
    Department of Medicine, Stanford University School of Medicine, Stanford, CA.
    Although controlled donation after circulatory determination of death (cDCDD) could increase the supply of donor lungs within the United States, the yield of lungs from cDCDD donors remains low compared with donation after neurologic determination of death (DNDD). To explore the reason for low lung yield from cDCDD donors, Scientific Registry of Transplant Recipient data were used to assess the impact of donor lung quality on cDCDD lung utilization by fitting a logistic regression model. The relationship between center volume and cDCDD use was assessed, and the distance between center and donor hospital was calculated by cDCDD status. Read More

    Argininosuccinic Aciduria-A Rare Indication for Liver Transplant: Report of Two Cases.
    Exp Clin Transplant 2016 Jan 14. Epub 2016 Jan 14.
    From the Memorial Sisli Hospital, Organ Transplantation Center, Istanbul, Turkey.
    Argininosuccinic aciduria is a urea cycle disorder caused by an argininosuccinate lyase enzyme deficiency that ends with nitrogen accumulation as ammonia. Argininosuccinic aciduria patients are at risk for long-term complications including poor neurocognitive outcome, hepatic disease, and systemic hypertension despite strict pharmacologic and dietary therapy. As the liver is the principle site of activity of the urea cycle, it is logical that a liver transplant should be an option, with careful patient selection, even in the absence of cirrhosis. Read More

    Adult venovenous extracorporeal membrane oxygenation for severe respiratory failure: Current status and future perspectives.
    Ann Card Anaesth 2016 Jan-Mar;19(1):97-111
    Department of Anesthesiology, Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic, Arizona, USA.
    Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory failure was proposed more than 40 years ago. Despite the publication of the ARDSNet study and adoption of lung protective ventilation, the mortality for acute respiratory failure due to acute respiratory distress syndrome has continued to remain high. This technology has evolved over the past couple of decades and has been noted to be safe and successful, especially during the worldwide H1N1 influenza pandemic with good survival rates. Read More

    Report of 3 Patients With Urea Cycle Defects Treated With Related Living-Donor Liver Transplant.
    Exp Clin Transplant 2015 Nov;13 Suppl 3:126-30
    From the Department of Pediatric Gastroenterology, Baskent University Faculty of Medicine, Ankara, Turkey.
    Urea cycle defects are a group of metabolic disorders caused by enzymatic disruption of the urea cycle pathway, transforming nitrogen to urea for excretion from the body. Severe cases present in early infancy with life-threatening metabolic decompensation, and these episodes of hyperammonemia can be fatal or result in permanent neurologic damage. Despite the progress in pharmacologic treatment, long-term survival is poor especially for severe cases. Read More

    Inpatient Neurologic Consultation in Solid Organ Transplant Patients.
    Semin Neurol 2015 Dec 23;35(6):699-707. Epub 2015 Nov 23.
    Department of Neurology, University of California San Francisco Medical Center, San Francisco, California.
    A third of solid organ transplant recipients experience neurologic complications after transplantation. In this article the author reviews common and uncommon complications of the perioperative period including stroke and peripheral neuropathy, neurotoxicity associated with immunosuppressant medications such as calcineurin inhibitors, and opportunistic infections that target the nervous system. A careful clinical history, neurologic examination, and medication review are vital in generating a differential diagnosis that will guide diagnostic testing and decisions regarding treatment and management, and early recognition of many disorders is imperative to prevent irreversible neurologic morbidity and death. Read More

    Liver Transplantation for Urea Cycle Disorders: Analysis of the United Network for Organ Sharing Database.
    Transplant Proc 2015 Oct;47(8):2413-8
    University of Washington, Division of Gastroenetrology and Hepatology, Seattle, Washington, USA. Electronic address:
    Background: Urea cycle disorders (UCD) are caused by rare inherited defects in the urea cycle enzymes leading to diminished ability to convert ammonia to urea in the liver. The resulting excess of circulating ammonia can lead to central nervous system toxicity and irreversible neurologic damage. Most cases are identified in children. Read More

    Present-Day Hospital Readmissions after Left Ventricular Assist Device Implantation: A Large Single-Center Study.
    Tex Heart Inst J 2015 Oct 1;42(5):419-29. Epub 2015 Oct 1.
    Left ventricular assist device (LVAD) therapy improves survival, hemodynamic status, and end-organ perfusion in patients with refractory advanced heart failure. Hospital readmission is an important measure of the intensity of LVAD support care. We analyzed readmissions of 148 patients (mean age, 53. Read More

    Association of Extrarenal Adverse Effects of Posttransplant Immunosuppression With Sex and ABCB1 Haplotypes.
    Medicine (Baltimore) 2015 Sep;94(37):e1315
    From the Nephrology Division; Medicine, School of Medicine and Biomedical Sciences (RCV, SC, NL, AG, NN, KMT); Erie County Medical Center, Buffalo, New York (RCV, AG, KMT); Immunosuppressive Pharmacology Research Program, Translational Pharmacology Research Core, NYS Center of Excellence in Bioinformatics and Life Sciences (CJM, SEM, LMC, KMT); Pharmacy, School of Pharmacy and Pharmaceutical Sciences (CJM, SEM, KMT); Biostatistics, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York (JDC, GEW); and Department of Pharmaceutical Sciences, College of Pharmacy, University of New England, Portland, Maine (DB).
    Extrarenal adverse effects (AEs) associated with calcineurin inhibitor (CNI) and mycophenolic acid (MPA) occur frequently but are unpredictable posttransplant complications. AEs may result from intracellular CNI accumulation and low activity of P-glycoprotein, encoded by the ABCB1 gene. Since ABCB1 single nucleotide polymorphisms (SNPs) and sex influence P-glycoprotein, we investigated haplotypes and extrarenal AEs. Read More

    Intracranial involvement of posttransplant lymphoproliferative disorder multiple myeloma.
    J Clin Neurosci 2015 Nov 12;22(11):1850-1. Epub 2015 Sep 12.
    Department of Pathology, Cleveland Clinic, Level 25, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:
    We report a 61-year-old man with intracranial multiple myeloma (MM) presenting as a posttransplant lymphoproliferative disorder (PTLD) following a kidney transplant. Two months after his transplant, the man developed acute rejection with Epstein-Barr virus (EBV) viremia, requiring aggressive immunosuppression. Twenty months following transplantation, the patient presented with multiple neurologic deficits. Read More

    Cat-Scratch Disease: Case Report and Review of the Literature.
    Transplant Proc 2015 Sep;47(7):2245-7
    Nephrology, Dialysis, and Transplantation Unit, University of Torino-AOU Città della Salute e della Scienza di Torino, Molinette, Italy.
    Cat-scratch disease (CSD) is caused by Bartonella henselae and characterized by self-limited fever and granulomatous lymphadenopathy. In some cases signs of a visceral, neurologic, and ocular involvement can also be encountered. In this report we describe the development of CSD in a kidney transplant patient. Read More

    Neurologic Complications After Kidney Transplantation.
    Semin Nephrol 2015 Jul;35(4):323-34
    Starzl Transplantation Institute, Department of Medicine, Renal and Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address:
    The clinical focus after kidney transplantation often is centered on graft function. However, neurologic complications are a common, significant, and under-recognized contributor to patient morbidity and mortality. Neurologic syndromes can arise through exacerbation of pre-existing conditions or can be newly acquired in the setting of increased risk of infection and drug toxicity after transplantation. Read More

    Hyponatremia, hypo-osmolality, and seizures in children early post-kidney transplant.
    Pediatr Transplant 2015 Nov 24;19(7):698-703. Epub 2015 Aug 24.
    Division of Pediatric Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    Post-transplant seizures are uncommon in young kidney transplant recipients but can be harbingers of devastating outcomes such as cerebral edema and death. We reviewed all transplants performed at our institution from January 2013 to January 2014 and compared three patients who seized within 24 h post-transplant (cases) with the remaining 33 transplant recipients (controls). Records were reviewed for hyponatremia, hypocalcemia, hypomagnesemia, BUN clearance, osmolality shifts, and blood pressure control in the first 24 h post-transplant. Read More

    Kidney-brain crosstalk in the acute and chronic setting.
    Nat Rev Nephrol 2015 Dec 18;11(12):707-19. Epub 2015 Aug 18.
    Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, International Renal Research Institute of Vicenza, Viale Rodolfi 37, 36100 Vicenza, Italy.
    Patients with kidney disease often exhibit multiple organ dysfunction that is caused, in part, by marked connectivity between the kidney and other organs and tissues. Substantial crosstalk occurs between the kidney and the brain, as indicated by the frequent presentation of neurological disorders, such as cerebrovascular disease, cognitive impairment, and neuropathy during the natural history of chronic kidney disease. The underlying pathophysiology of such comorbid neurological disorders in kidney disease is governed by shared anatomic and vasoregulatory systems and humoral and non-humoral bidirectional pathways that affect both the kidney and the brain. Read More

    Excellent long-term outcome of renal transplantation in cystinosis patients.
    Orphanet J Rare Dis 2015 Jul 25;10:90. Epub 2015 Jul 25.
    Service de Néphrologie-Transplantation, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France.
    Background: Cystinosis is a rare lysosomal disorder leading to end stage renal disease in more than 90 % of patients before 20 years of age. Data about safety and efficiency of renal transplantation in patients with cystinosis is scarce. We evaluated long-term outcomes of renal transplantation in adult patients with cystinosis. Read More

    Donation After Circulatory Determination of Death Lung Transplantation for Pulmonary Arterial Hypertension: Passing the Toughest Test.
    Am J Transplant 2015 Dec 17;15(12):3208-14. Epub 2015 Jul 17.
    Lung Transplant Service, Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia.
    Lung transplantation (LTx) is a therapeutic option for severe pulmonary arterial hypertension (PAH) patients failing optimal medical therapy. The use of donation after circulatory determination of death (DCDD) donor lungs for PAH LTx has rarely been reported, primarily reflecting concerns that DCDD lungs represent extended criteria donors, at risk of morbidity and mortality. A retrospective study of all Alfred Hospital DCDD and DNDD (donation after neurologic determination of death) PAH LTx was undertaken. Read More

    Bilateral Lung Transplantation From a Donor With Heparin-Induced Thrombocytopenia.
    Ann Thorac Surg 2015 Jul;100(1):e1-3
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address:
    We report the case of a 46-year-old male patient with a history of cystic fibrosis who received bilateral lung transplantation from a donor who died secondary to complications of heparin-induced thrombocytopenia. Postoperatively, he exhibited transient focal neurologic deficits and radiographic evidence of multiple cortical and subcortical infarctions. He was treated with a combination of fondaparinux and standard immunosuppressive therapy, made a full recovery, and experienced significantly improved lung function compared to pretransplantation capacity. Read More

    Central nervous system complications after liver transplantation.
    J Clin Neurosci 2015 Aug 19;22(8):1355-9. Epub 2015 Jun 19.
    Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul National University, 28, Yongon-dong, Chongro-gu, Seoul 110-744, South Korea; Department of Neurology, The Armed Forces Capital Hospital, Gyeunggido, South Korea.
    We investigated the diversity of central nervous system complications after liver transplantation in terms of clinical manifestations and temporal course. Liver transplantation is a lifesaving option for end stage liver disease patients but post-transplantation neurologic complications can hamper recovery. Between 1 January 2001 and 31 December 2010, patients who had undergone liver transplantation at a single tertiary university hospital were included. Read More

    Early Liver Transplantation for Neonatal-Onset Methylmalonic Acidemia.
    Pediatrics 2015 Jul 15;136(1):e252-6. Epub 2015 Jun 15.
    Department of Pediatrics,
    With conventional dietary treatment, the clinical course of methylmalonic acidemia due to cobalamin-unresponsive methylmalonyl-CoA mutase (MCM) deficiency is characterized by the persistent risk of recurrent life-threatening decompensation episodes with metabolic acidosis, hyperammonemia, and coma. Liver transplant has been proposed as an alternative treatment and anecdotally attempted in the last 2 decades with inconsistent results. Most criticisms of this approach have been directed at the continuing risk of neurologic and renal damage after transplant. Read More

    Living-donor and Deceased-donor Renal Transplantation: Differences in Early Outcome--A Single-center Experience.
    Transplant Proc 2015 May;47(4):958-62
    Centro Hospitalar do Porto, Anesthesiology/Intensive Care/Emergency Department, Porto, Portugal.
    Living-donor renal transplant (LDRT) yields better long-term outcomes than cadaver-donor renal transplant (CDRT). The aim of the present study was to identify the differences in the early postoperative period between LDRT and CDRT recipients. A retrospective study was conducted including all patients receiving a LDRT and CDRT in this center in 2012 and 2013. Read More

    The neurology of solid organ transplantation.
    Curr Neurol Neurosci Rep 2015 Jul;15(7):38
    Department of Neurology, University of Pittsburgh Medical Center, 3471 Fifth Ave #810, Pittsburgh, PA, 15213, USA,
    Transplantation is the rescue treatment for end-stage organ failure with more than 110,000 solid organs transplantations performed worldwide annually. Recent advances in transplantation procedures and posttransplantation management have improved long-term survival and quality of life of transplant recipients, shifting the focus from acute perioperative critical care needs toward long-term chronic medical problems. Neurologic complications affect up to 30-60 % of solid organ transplant recipients. Read More

    [Infective endocarditis caused by Chlamydia pneumoniae after liver transplantation. Case report].
    Orv Hetil 2015 May;156(22):896-900
    Belgyógyászati Intézet, Nephrológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar, Klinikai Központ FMC-Debrecen, Nagyerdei krt. 98., 4012.
    The incidence of infective endocarditis is underestimated in solid organ transplant recipients. The spectrum of pathogens is different from the general population. The authors report the successful treatment of a 58-year-old woman with infective endocarditis caused by atypical microorganism and presented with atypical manifestations. Read More

    Fatal West Nile Virus Encephalitis in a Heart Transplant Recipient.
    J Clin Microbiol 2015 Aug 20;53(8):2749-52. Epub 2015 May 20.
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA
    The diagnosis of encephalitis is particularly challenging in immunocompromised patients. We report here a case of fatal West Nile virus encephalitis confounded by the presence of budding yeast in the cerebrospinal fluid (CSF) from a patient who had undergone heart transplantation for dilated cardiomyopathy 11 months prior to presentation of neurologic symptoms. Read More

    Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging.
    Pediatr Transplant 2015 Aug 12;19(5):527-30. Epub 2015 May 12.
    Pediatric Liver Care Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    Unlabelled: Liver transplantation treats the hepatic affectation of UCDs; however, irreversible neurologic damage pretransplant is difficult to assess providing transplant teams with ethical dilemmas for liver transplantation. The purpose of our study was to determine whether pretransplant neuroimaging can predict developmental outcomes post-liver-transplant in children with UCDs.

    Methods: Patients undergoing liver transplantation for UCDs at Cincinnati Children's Hospital Medical Center between 2002 and 2012 were identified. Read More

    Dental management of a patient with Wilson's disease.
    Gen Dent 2015 May-Jun;63(3):64-6
    Wilson's disease (WD) is an autosomal recessive genetic disease, characterized by the accumulation of copper in the body--primarily in the brain and liver--due to defective biliary copper excretion by hepatocytes. WD may manifest clinically as liver disease, neurologic symptoms, and Kayser-Fleischer corneal rings. This article presents a case involving a 43-year-old man who had WD prior to liver transplantation. Read More

    PRES in Children Undergoing Hematopoietic Stem Cell or Solid Organ Transplantation.
    Pediatrics 2015 May;135(5):890-901
    Department of Pediatrics, "Lalla Seràgnoli," Hematology-Oncology Unit, University of Bologna, Bologna, Italy; and.
    Posterior reversible encephalopathy syndrome (PRES) is a clinical neuroradiologic entity that is becoming increasingly well known and documented in pediatrics. It is characterized by a variable association of seizures, headache, vomiting, altered mental status, visual disturbances, and seizures, as well as imaging suggesting white-gray matter edema involving the posterior regions of the central nervous system in most cases. The pathophysiology of PRES remains unclear. Read More

    Neurologic complications after liver transplant: experience at a single center.
    Exp Clin Transplant 2015 Apr;13 Suppl 1:327-30
    From the Department of Neurology, Baskent University, School of Medicine, Ankara, Turkey.
    Objectives: Neurologic complications occur frequently after liver transplants. Up to 43% of patients experience severe postsurgical neurologic complications. These complications are significantly associated with longer hospital stay, morbidity, and mortality. Read More

    Diagnostic value of coagulation factor and intracranial pressure monitoring in acute liver failure from heat stroke: case report and review of the literature.
    Transplant Proc 2015 Apr;47(3):817-9
    Transplant and Advanced Liver Diseases, Banner Good Samaritan Medical Center, Phoenix, Arizona; University of Arizona College of Medicine, Phoenix, Arizona.
    Background: Exertional heat stroke (HS) with resultant acute liver failure (ALF) is a rare condition with high mortality. Diagnosis of ALF in the context of HS is confounded by numerous laboratory abnormalities related to multisystem organ dysfunction.

    Case Report: We present the case of a 20-year-old male athlete with exertional HS who developed ALF and was treated successfully with orthotopic liver transplantation. Read More

    Outcome of Patients with Immunoglobulin Light-Chain Amyloidosis with Lung, Liver, Gastrointestinal, Neurologic, and Soft Tissue Involvement after Autologous Hematopoietic Stem Cell Transplantation.
    Biol Blood Marrow Transplant 2015 Aug 2;21(8):1413-7. Epub 2015 Apr 2.
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:
    There is limited information on the outcome when organs other than heart or kidneys are involved by immunoglobulin light-chain amyloidosis (AL). We report the outcome of 53 patients with AL with gastrointestinal (GI), peripheral nerve (PN), liver, lung, or soft-tissue involvement, who underwent high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HCT) at our institution between 1997 and 2013. The median age at auto-HCT was 56 years (range, 35 to 74). Read More

    Early and late complications after liver transplantation for propionic acidemia in children: a two centers study.
    Am J Transplant 2015 Mar 12;15(3):786-91. Epub 2015 Feb 12.
    Laboratory of Intestinal Immunity, Unité INSERM UMR1163, Institut IMAGINE, Paris, France.
    Propionic acidemia (PA) is a severe metabolic disorder with cardiac and neurologic complications and a poor quality of life. Liver transplantation (LT) was thus proposed in PA to increase enzyme activity. We studied retrospectively LT in PA in two European centers. Read More

    Roseoloviruses: unmet needs and research priorities: perspective.
    Curr Opin Virol 2014 Dec 14;9:167-9. Epub 2014 Nov 14.
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
    The human roseoloviruses, human herpesviruses 6A (HHV-6A), HHV-6B, and HHV-7, are highly prevalent viruses that typically cause fever/rash illnesses such as roseola during early life primary infections. They also cause significant neurologic disease and complications following stem cell and solid organ transplantation, and have suggestive but less certain etiologic associations with other neurologic diseases and immunologic disorders. The US National Institute of Allergy and Infectious Diseases recently sponsored a workshop (Roseoloviruses: Clinical Impact, Interventions, and Research Needs) to discuss disease associations, novel biology, and the many unmet research needs related to Roseoloviruses. Read More

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