550 results match your criteria Neurologic Complications of Organ Transplantation


Application of Muse Cell Therapy to Stroke.

Adv Exp Med Biol 2018 ;1103:167-186

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Stroke is defined as a sudden onset of neurologic deficits arising from cerebrovascular complications. It is the second common cause of death around the world and the major cause of disability. Because brain is an organ with complicated neural networks and neurons are highly differentiated, it has been traditionally considered to possess a limited potential for regeneration. Read More

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http://dx.doi.org/10.1007/978-4-431-56847-6_9DOI Listing
January 2018

Complications of Solid Organ Transplantation: Cardiovascular, Neurologic, Renal, and Gastrointestinal.

Crit Care Clin 2019 Jan 25;35(1):169-186. Epub 2018 Oct 25.

Department of Critical Care Medicine, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Despite improvements in overall graft function and patient survival rates after solid organ transplantation, complications can lead to significant morbidity and mortality. Cardiovascular complications include heart failure, arrhythmias leading to sudden death, hypertension, left ventricular hypertrophy, and allograft vasculopathy in heart transplantation. Neurologic complications include stroke, posterior reversible encephalopathy syndrome, infections, neuromuscular disease, seizure disorders, and neoplastic disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07490704183074
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http://dx.doi.org/10.1016/j.ccc.2018.08.011DOI Listing
January 2019
7 Reads

A pediatric neurologic assessment score may drive the eculizumab-based treatment of Escherichia coli-related hemolytic uremic syndrome with neurological involvement.

Pediatr Nephrol 2018 Oct 25. Epub 2018 Oct 25.

Pediatric Nephrology and Dialysis Unit, Pediatric Hospital "Giovanni XXIII", Bari, Italy.

Background: Thrombotic microangiopathy (TMA) is a clinical syndrome encompassing a large group of rare but severe disorders including thrombotic thrombocytopenic purpura (TTP) and both typical and atypical forms of hemolytic uremic syndrome (HUS). The key role of the complement system is well known in TTP and atypical HUS, but recent reports describe its involvement in the pathogenesis of HUS secondary to gastrointestinal infections due to Shiga toxin-producing Escherichia coli (STEC).

Methods: TMA mainly affects the kidney, but extra-renal complications are frequently described. Read More

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http://link.springer.com/10.1007/s00467-018-4112-2
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http://dx.doi.org/10.1007/s00467-018-4112-2DOI Listing
October 2018
7 Reads

Emergent Neuroimaging in the Oncologic and Immunosuppressed Patient.

Neuroimaging Clin N Am 2018 Aug;28(3):397-417

Neuroradiology Division, Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Neuroimaging in the emergency department increasingly involves patients at increased risk for acute neurologic complications from malignancy and immunosuppression, including patients with organ transplantation, diabetes mellitus, treatment of chronic disease, and HIV positivity. These patients are susceptible to the same infections and emergencies as immunocompetent patients, but may present differently with common illnesses and are susceptible to a variety of other diseases. This article reviews important patient risk factors, emergent central nervous system abnormalities, and their imaging findings. Read More

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http://dx.doi.org/10.1016/j.nic.2018.03.004DOI Listing
August 2018
7 Reads

Intracranial Fungal Infection After Solid-Organ Transplant.

Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):179-182

Department of Neurosurgery, Baskent University Faculty of Medicine, Ankara, Turkey.

Neurologic complications after solid-organ transplant reveal a great spectrum of pathologies. Intracranial hemorrhages, cerebral ischemic lesions, infarctions, lymphoproliferative disorders, and infections, including aspergillosis, have been observed after liver transplant. Fungi constitute nearly 5% of all central nervous system infections, mainly occurring in immunocompromised patients. Read More

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http://dx.doi.org/10.6002/ect.TOND-TDTD2017.P56DOI Listing
March 2018
2 Reads

Complications of Liver Transplant in Adult Patients With the Hepatic Form of Wilson Disease.

Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):38-40

From the Department of Neurology, Başkent University, Ankara, Turkey.

Objectives: Wilson disease is an autosomal, recessive, inherited disorder of copper metabolism that results in the accumulation of copper in many organs and tissues. This disease is mainly characterized by dysfunction due to copper accumulation in the liver, kidney, brain, cornea, bone, heart, and blood cells. The clinical spectrum is broad in Wilson disease. Read More

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http://dx.doi.org/0.6002/ect.TOND-TDTD2017.O6DOI Listing
March 2018
3 Reads

Association between incision technique for hamstring tendon harvest in anterior cruciate ligament reconstruction and the risk of injury to the infra-patellar branch of the saphenous nerve: a meta-analysis.

Knee Surg Sports Traumatol Arthrosc 2018 Aug 8;26(8):2410-2423. Epub 2018 Feb 8.

Sicily Department, Rizzoli Orthopaedic Institute, Bagheria, Palermo, Italy.

Purpose: To determine how the incision technique for hamstring tendon (HT) harvest in anterior cruciate ligament (ACL) reconstruction affects the risk of injury to the IPBSN and clinical outcome.

Methods: A systematic literature search of the MEDLINE/Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL) and EBSCOhost electronic databases and clinicaltrials.gov for unpublished studies was performed to identify comparative studies investigating injury to the IPBSN after HT ACL reconstruction by comparing at least two different incision techniques. Read More

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http://dx.doi.org/10.1007/s00167-018-4858-xDOI Listing
August 2018
8 Reads

Incidence, risk factors, and outcomes related with neurological events after liver transplantation in adult and pediatric recipients.

Pediatr Transplant 2018 05 7;22(3):e13159. Epub 2018 Feb 7.

Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Universidad Austral, Pilar, Argentina.

Controversy exists whether NE after LT are more frequently observed in children or adults. We aimed to compare the incidence and outcomes for NE after LT in pediatric and adult recipients. A single-center cohort study, including all LT between 2001 and 2013, was performed. Read More

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http://dx.doi.org/10.1111/petr.13159DOI Listing
May 2018
37 Reads
1.630 Impact Factor

Therapeutic Plasma Exchange in Critically Ill Children Requiring Intensive Care.

Pediatr Crit Care Med 2018 Feb;19(2):e97-e104

Paediatric Intensive Care Unit, Royal Children's Hospital Melbourne, Australia.

Objective: To characterize the clinical indications, procedural safety, and outcome of critically ill children requiring therapeutic plasma exchange.

Design: Retrospective observational study based on a prospective registry.

Setting: Tertiary and quaternary referral 30-bed PICU. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001400DOI Listing
February 2018
10 Reads

High Intrapatient Variability of Tacrolimus Exposure in the Early Period After Liver Transplantation Is Associated With Poorer Outcomes.

Transplantation 2018 03;102(3):e108-e114

INSERM, CIC 1414, Rennes, France.

Background: Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (IPV) on graft and patient outcomes after LT. Read More

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http://dx.doi.org/10.1097/TP.0000000000002052DOI Listing
March 2018
9 Reads
3.830 Impact Factor

Brain MRI findings in acute hepatic encephalopathy in liver transplant recipients.

Acta Neurol Belg 2018 Jun 23;118(2):251-258. Epub 2017 Dec 23.

Department of Nuclear Medicine, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, China.

Acute hepatic encephalopathy has significant morbidity and mortality in liver transplant recipients unless it is promptly treated. We evaluated the brain magnetic resonance (MR) imaging findings associated with acute hepatic encephalopathy in transplant recipients. We retrospectively reviewed the clinical and imaging data and outcomes of twenty-five liver transplant patients (16 male; mean age, 49. Read More

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http://dx.doi.org/10.1007/s13760-017-0875-7DOI Listing
June 2018
7 Reads

Chronic organ failure in adult sickle cell disease.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):435-439

UCSF Benioff Children's Hospital Oakland, Oakland, CA.

Sickle cell disease is now a chronic adult illness characterized by progressive multiorgan failure, particularly involving the brain and kidney. The etiology is multifactorial; it includes hemolysis and nitric oxide deficiency. As patients age, most experience neurologic insult. Read More

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http://dx.doi.org/10.1182/asheducation-2017.1.435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142529PMC
December 2017
9 Reads

Progressive multifocal leukoencephalopathy - immune reconstitution inflammatory syndrome (PML-IRIS) in liver transplant recipient.

Mult Scler Relat Disord 2017 Oct 19;17:135-137. Epub 2017 Jul 19.

Clinical Radiology Institute, University Medical Centre Ljubljana, Zaloška cesta 7, 1000 Ljubljana, Slovenia.

65-year-old liver transplant recipient presented with progressive neurologic dysfunction. CSF analysis revealed high JC virus load and MRI findings suggested the diagnosis of progressive multifocal leukoencephalopathy (PML). Cidofovir and mirtazapine were initiated and patient's regular immunosuppressants were reduced. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348173017
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http://dx.doi.org/10.1016/j.msard.2017.07.018DOI Listing
October 2017
4 Reads

Neurologic Complications of Solid Organ Transplantation.

Neurol Clin 2017 Nov;35(4):809-823

Departments of Critical Care Medicine, Neurology and Neurosurgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address:

Among patients receiving solid organ transplants, approximately one-third will develop neurologic symptoms. Most of these neurologic symptoms will occur within 30 days of their transplantation. These neurologic symptoms include neurotoxicity of immunosuppressive agents, seizures, encephalopathy, cerebrovascular events, opportunistic infections, posttransplant lymphoproliferative disorder, and central pontine myelinosis. Read More

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http://dx.doi.org/10.1016/j.ncl.2017.06.013DOI Listing
November 2017
24 Reads

Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry.

J Pediatr Gastroenterol Nutr 2017 Nov;65(5):561-568

*The Department of Pediatrics, Jinshan Hospital, Fudan University, Shanghai, China †Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH ‡Center for Pediatric Liver Diseases, Children's Hospital of Fudan University §Department of Pediatrics, Shanghai Medical College of Fudan University, Shanghai, China ||Institut für Pathologie, Medizinische Universität Graz, Graz, Austria.

Objectives: Cerebrotendinous xanthomatosis (CTX) is caused by defects in sterol 27-hydroxylase (CYP27A1, encoded by CYP27A1), a key enzyme in the bile acid synthesis pathway. CTX usually presents as neurologic disease in adults or older children. The rare reports of CTX manifest as neonatal cholestasis assess the cholestasis as transient, with patient survival. Read More

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http://Insights.ovid.com/crossref?an=00005176-201711000-0001
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http://dx.doi.org/10.1097/MPG.0000000000001730DOI Listing
November 2017
13 Reads

A Case Report: Organs From a Donor With Highly Virulent Zoonotic Outbreak Strain of Streptococcus agalactiae Serotype III, Multilocus Sequence Type 283 Infective Endocarditis Did Not Result in Transmission With Adequate Prophylactic Antibiotic Cover.

Transplant Proc 2017 Sep;49(7):1587-1590

Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.

In 2015, an outbreak involving a highly virulent zoonotic outbreak strain of Streptococcus agalactiae serotype III, multilocus sequence type 283 occurred in Singapore with increased neurologic complications, septic arthritis, and spinal infections in healthier patients. We report a case of a successful dual kidney transplant from a deceased donor with infective endocarditis and disseminated infection with the same strain of S agalactiae and we review the current literature. Read More

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http://dx.doi.org/10.1016/j.transproceed.2017.06.004DOI Listing
September 2017

Diagnosis and treatment of tyrosinemia type I: a US and Canadian consensus group review and recommendations.

Genet Med 2017 12 3;19(12). Epub 2017 Aug 3.

Division of Genetic Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.

Tyrosinemia type I (hepatorenal tyrosinemia, HT-1) is an autosomal recessive condition resulting in hepatic failure with comorbidities involving the renal and neurologic systems and long term risks for hepatocellular carcinoma. An effective medical treatment with 2-[2-nitro-4-trifluoromethylbenzoyl]-1,3-cyclohexanedione (NTBC) exists but requires early identification of affected children for optimal long-term results. Newborn screening (NBS) utilizing blood succinylacetone as the NBS marker is superior to observing tyrosine levels as a way of identifying neonates with HT-1. Read More

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http://dx.doi.org/10.1038/gim.2017.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729346PMC
December 2017
13 Reads

Renal Transplant in the Abnormal Bladder: Long-Term Follow-Up.

Exp Clin Transplant 2018 Feb 31;16(1):10-15. Epub 2017 Jul 31.

From the Urology Department, Menofia University Hospitals, Egypt.

Objectives: Normal urinary bladder stores urine at low pressure, does not leak, and completely empties by natural voiding. An abnormal bladder may be due to neurologic or urologic disorders that render the bladder of small capacity, of high storage pressure, or of poor compliance. The aim of this study was to determine the long-term outcomes of renal transplant in patients with abnormal bladders. Read More

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http://dx.doi.org/10.6002/ect.2016.0193DOI Listing
February 2018
1 Read

Tyrosinemia and Liver Transplantation: Experience at CHU Sainte-Justine.

Adv Exp Med Biol 2017 ;959:67-73

Departments of Nutrition (MB) and Radiology (JD), Divisions of Gastroenterology, Hepatology and Nutrition (FA, UH), Medical Genetics (CBG, MG, GAM) and Nephrology (AM, VP), Department of Pediatrics and Department of Pharmacy (SA, JFB), CHU Sainte-Justine and Université de Montréal, Montreal, Canada.

Tyrosinemia is a disease of the tyrosine metabolism, affecting mainly liver, kidney and peripheral nerves. Two forms of liver disease caused by a deficiency of FAH are recognised: (1) acute liver failure; (2) chronic liver disease. Since the introduction of NTBC [2-(2-nitro-4-trifluoromethyl benzoyl)-1-3-cyclohexanedione] (nitisinone) in the treatment of tyrosinemia, no liver disease has been observed when started in the first weeks of life. Read More

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http://dx.doi.org/10.1007/978-3-319-55780-9_5DOI Listing
December 2017
12 Reads

First Canadian experience with donation after cardiac death simultaneous pancreas and kidney transplants.

Can J Surg 2017 Sep;60(5):323-328

From the Department of Surgery, Division of Urology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont. (Anderson); the Western University Schulich School of Medicine and Dentistry, London, Ont. (McAlister, Sener, Luke); the Department of Surgery, Western University, London, Ont. (Aquil, McLean, McAlister, Sener, Luke); and the Multi-Organ Transplant Program, London Health Sciences Centre, London, Ont. (Aquil, McLean, McAlister, Sener, Luke).

Background: Compared with neurologic determination of death (NDD) donor organs, donation after cardiac death (DCD) donor organs have traditionally been considered of inferior quality owing to warm ischemia experienced during procurement. We present, to our knowledge, the first analysis of simultaneous pancreas and kidney (SPK) transplants using DCD donor organs in Canada.

Methods: We carried out a retrospective cohort study of SPK transplants from 13 DCD and 68 NDD donors performed between October 2008 and July 2016. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608581PMC
September 2017
12 Reads

Hepatitis E virus infection and acute non-traumatic neurological injury: A prospective multicentre study.

J Hepatol 2017 11 20;67(5):925-932. Epub 2017 Jul 20.

Department of Neurology and Immunology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands.

Background & Aims: Hepatitis E virus (HEV) has been associated with a number of neurological syndromes, but causality has not yet been established. The aim of this study was to explore the relationship between HEV and neurological illness by prospective HEV testing of patients presenting with acute non-traumatic neurological injury.

Methods: Four hundred and sixty-four consecutive patients presenting to hospital with acute non-traumatic neurological illnesses were tested for HEV by serology and PCR from four centres in the UK, France and the Netherlands. Read More

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http://dx.doi.org/10.1016/j.jhep.2017.07.010DOI Listing
November 2017
20 Reads

The Impact of Toxicities on First-Year Outcomes after Ex Vivo CD34-Selected Allogeneic Hematopoietic Cell Transplantation in Adults with Hematologic Malignancies.

Biol Blood Marrow Transplant 2017 Nov 18;23(11):2004-2011. Epub 2017 Jul 18.

Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York. Electronic address:

Factors that impact first-year morbidity and mortality in adults undergoing myeloablative allogeneic hematopoietic cell transplantation with ex vivo CD34 selection have not been previously reported. We assessed all toxicities ≥ grade 3 from the start of conditioning to date of death, relapse, or last contact in 200 patients during the first year after transplantation, identifying 1885 individual toxicities among 17 organ-based toxicity groups. The most prevalent toxicities in the first year were of infectious, metabolic, hematologic, oral/gastrointestinal, hepatic, cardiac, and pulmonary etiologies. Read More

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http://dx.doi.org/10.1016/j.bbmt.2017.07.012DOI Listing
November 2017
15 Reads

Neurologic complications in kidney transplant recipients.

Folia Neuropathol 2017 ;55(2):86-109

Transplantology experiences continuous growth and kidney transplantation is the most frequently transplanted solid organ. Metabolic, cardiovascular, infectious or kidney function-related aspects are widely recognised and are of key interest for transplant doctors. Neurological complications seen in these patients, although known, are less covered in the literature. Read More

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https://www.termedia.pl/doi/10.5114/fn.2017.68577
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http://dx.doi.org/10.5114/fn.2017.68577DOI Listing
February 2018
11 Reads

Neurologic Complications of Transplantation.

Authors:
Amy A Pruitt

Continuum (Minneap Minn) 2017 06;23(3, Neurology of Systemic Disease):802-821

Purpose Of Review: This article describes the diagnosis and management of neurologic problems during hematopoietic cell and solid organ transplantation using time elapsed since transplantation as a guide to expected complications, including drug toxicities, infections, strokes, autoimmune phenomena, disease recurrence, and secondary neoplasms.

Recent Findings: Growing clinical experience in the neurology of transplantation has led to appreciation of the diverse clinical and radiographic spectrum of calcineurin inhibitor-related posterior reversible encephalopathy syndrome (PRES) and progressive multifocal leukoencephalopathy. Novel autoimmune phenomena illustrate the delicate balance between adequate immunosuppression and necessary host inflammatory defenses that can lead to organ rejection. Read More

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http://dx.doi.org/10.1212/CON.0000000000000473DOI Listing
June 2017
18 Reads

High Frequency of Neuroimaging Abnormalities Among Pediatric Patients With Sepsis Who Undergo Neuroimaging.

Pediatr Crit Care Med 2017 Jul;18(7):607-613

1Division of Pediatric Critical Care, University of Louisville, Norton Children's Hospital, Louisville, KY. 2Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 3Department of Neurosurgery, University of Cincinnati Medical Center, Cincinnati, OH. 4Division of Neuroradiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 5Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 6Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Objectives: This study was intended to describe and correlate the neuroimaging findings in pediatric patients after sepsis.

Design: Retrospective chart review.

Setting: Single tertiary care PICU. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503765PMC
July 2017
18 Reads

Wilson disease in children.

Handb Clin Neurol 2017 ;142:141-156

Departments of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.

Wilson disease (WD) is an inherited disorder mainly of hepatocellular copper disposition, due to dysfunction of the Wilson ATPase, a P-ATPase encoded by the gene ATP7B. In children, as in older age brackets, clinical disease is highly diverse. Although hepatic disease is the common presentation in children/adolescents, neurologic, psychiatric, and hematologic clinical presentations do occur. Read More

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http://dx.doi.org/10.1016/B978-0-444-63625-6.00012-4DOI Listing
March 2018
8 Reads

Prevention of the Osmotic Demyelination Syndrome After Liver Transplantation: A Multidisciplinary Perspective.

Am J Transplant 2017 Oct 26;17(10):2537-2545. Epub 2017 May 26.

Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

The osmotic demyelination syndrome (ODS) is a serious neurologic condition that occurs in the setting of rapid correction of hyponatremia. It presents with protean manifestations, from encephalopathy to the "locked-in" syndrome. ODS can complicate liver transplantation (LT), and its incidence may increase with the inclusion of serum sodium as a factor in the Mayo End-Stage Liver Disease score. Read More

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http://doi.wiley.com/10.1111/ajt.14317
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http://dx.doi.org/10.1111/ajt.14317DOI Listing
October 2017
4 Reads

Analysis of magnetic resonance imaging findings of children with neurologic complications after liver transplantation.

Radiol Med 2017 Aug 3;122(8):617-622. Epub 2017 Apr 3.

Department of General Surgery, Inonu University School of Medicine, 44100, Malatya, Turkey.

Objective: To analyze the magnetic resonance imaging findings in children diagnosed with neurologic complications after liver transplantation (LT).

Materials And Methods: A total of 39 patients diagnosed with neurologic complications following LT between 2010 and 2016. Neuroradiologic imaging was performed using cranial magnetic resonance imaging (MRI). Read More

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http://link.springer.com/10.1007/s11547-017-0756-4
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http://dx.doi.org/10.1007/s11547-017-0756-4DOI Listing
August 2017
6 Reads

Relation between sexual dysfunctions and epilepsy, type of epilepsy, type of antiepileptic drugs: a prospective study.

Urologia 2017 Apr 18;84(2):88-92. Epub 2017 Mar 18.

Department of Experimental Biomedicine and Clinic Neuroscience, University of Palermo, Palermo - Italy.

Introduction: The aim of this study was to evaluate the incidence of sexual dysfunctions in males with epilepsy, the type of epilepsy, the frequency of seizures, the type of antiepileptic drugs (AEDs), the serum hormonal profile and the presence of psychiatric comorbidity.

Methods: Sixty-one patients focused on type of epilepsy, frequency of seizures, AEDs, hormonal profile and presence of mood disorders. We excluded all patients with severe neurologic and psychiatric impairment and patient who were not able to fill questionnaires. Read More

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http://dx.doi.org/10.5301/uro.5000222DOI Listing
April 2017
15 Reads

Auxiliary Partial Orthotopic Living Liver Transplant for Wilson Disease.

Exp Clin Transplant 2017 Feb;15(Suppl 1):182-184

Department of General Surgery and Transplantation, Baskent University, Ankara, Turkey.

Wilson disease is a genetic disease involving copper metabolism disturbances that result in copper accumulations, especially in the liver and brain. Wilson disease can be treated with pharmacologic agents, such as chelators that induce urinary excretion of copper or zinc salts that inhibit copper absorption in the digestive tract. Liver transplant is the only treatment option for Wilson disease when liver failure has occurred. Read More

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http://dx.doi.org/10.6002/ect.mesot2016.P64DOI Listing
February 2017
8 Reads

Zika Virus Meningoencephalitis in an Immunocompromised Patient.

Mayo Clin Proc 2017 03;92(3):460-466

Cardiology Centre, Internal Medicine Department, Medical School of Ribeirão Preto, University of São Paulo, Brazil.

The World Health Organization considers the Zika virus (ZIKV) outbreak in the Americas a global public health emergency. The neurologic complications due to ZIKV infection comprise microcephaly, meningoencephalitis, and Guillain-Barré syndrome. We describe a fatal case of an adult patient receiving an immunosuppressive regimen following heart transplant. Read More

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http://dx.doi.org/10.1016/j.mayocp.2016.12.019DOI Listing
March 2017
12 Reads

Imaging spectrum of central nervous system complications of hematopoietic stem cell and solid organ transplantation.

Neuroradiology 2017 Feb 2;59(2):105-126. Epub 2017 Mar 2.

Section of Neuroradiology, Department of Radiology and Nuclear Medicine, Oslo University Hospital-Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.

Neurologic complications are common after hematopoietic stem cell transplantation (HSCT) and solid organ transplantation (SOT) and affect 30-60% of transplant recipients. The aim of this article is to provide a practical imaging approach based on the timeline and etiology of CNS abnormalities, and neurologic complications related to transplantation of specific organs. The lesions will be classified based upon the interval from HSCT procedure: pre-engraftment period <30 days, early post-engraftment period 30-100 days, late post-engraftment period >100 days, and the interval from SOT procedure: postoperative phase 1-4 weeks, early posttransplant syndromes 1-6 months, late posttransplant syndromes >6 months. Read More

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http://dx.doi.org/10.1007/s00234-017-1804-4DOI Listing
February 2017
28 Reads

Neurologic Complications of Transplantation.

Authors:
Rajat Dhar

Neurocrit Care 2018 Feb;28(1):4-11

Department of Neurology (Division of Neurocritical Care), Washington University in St. Louis School of Medicine, 660 S Euclid Avenue, Campus Box 8111, Saint Louis, MO, 63110, USA.

Neurologic disturbances including encephalopathy, seizures, and focal deficits complicate the course 10-30% of patients undergoing organ or stem cell transplantation. While much or this morbidity is multifactorial and often associated with extra-cerebral dysfunction (e.g. Read More

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http://dx.doi.org/10.1007/s12028-017-0387-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581289PMC
February 2018
1 Read

Renal Transplant in Patients With Abnormal Bladder: Impact of Causes on Graft Function and Survival.

Exp Clin Transplant 2017 Dec 23;15(6):609-614. Epub 2017 Feb 23.

From the Urology Department, Menofia University Hospitals, Menofia, Egypt; and the Sheffield Kidney Institute, Sheffield Teaching Hospitals, Sheffield, United Kingdom.

Objectives: Successful kidney transplant depends partly on the normal physiologic functioning of the bladder, which involves effective urine storage and emptying. The bladder may become abnormal owing to various urologic and neuropathic disorders. Patients with abnormal bladders need careful management before and after transplant. Read More

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http://dx.doi.org/10.6002/ect.2016.0189DOI Listing
December 2017
1 Read

Neurologic complications of transplantation.

Authors:
R Dhar

Handb Clin Neurol 2017 ;141:545-572

Division of Neurocritical Care, Department of Neurology, Washington University, St. Louis, MO, USA. Electronic address:

Major neurologic morbidity, such as seizures and encephalopathy, complicates 20-30% of organ and stem cell transplantation procedures. The majority of these disorders occur in the early posttransplant period, but recipients remain at risk for opportunistic infections and other nervous system disorders for many years. These long-term risks may be increasing as acute survival increases, and a greater number of "sicker" patients are exposed to long-term immunosuppression. Read More

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http://dx.doi.org/10.1016/B978-0-444-63599-0.00030-2DOI Listing
March 2017
13 Reads

Clinical Characteristics of Transplant-associated Encephalopathy in Children.

J Korean Med Sci 2017 Mar;32(3):457-464

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

We aimed to analyze characteristics of encephalopathy after both hematopoietic stem cell and solid organ pediatric transplantation. We retrospectively reviewed medical records of 662 pediatric transplant recipients (201 with liver transplantation [LT], 55 with heart transplantation [HT], and 67 with kidney transplantation [KT], 339 with allogeneic hematopoietic stem cell transplantation [HSCT]) who received their graft organs at Asan Medical Center between January 2000 and July 2014. Of the 662 patients, 50 (7. Read More

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http://dx.doi.org/10.3346/jkms.2017.32.3.457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290105PMC
March 2017
9 Reads

Cardiac transplantation in Friedreich Ataxia: Extended follow-up.

J Neurol Sci 2017 Apr 10;375:471-473. Epub 2017 Jan 10.

Department of Pediatrics and Neurology, The Children's Hospital of Philadelphia, PA, United States; Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

Friedreich Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder most commonly caused by guanine-adenine-adenine (GAA) trinucleotide repeat expansions in both alleles of the FXN gene. Although progressive ataxia remains the hallmark clinical feature, patients with FRDA are at high risk of developing cardiomyopathy, often resulting in premature death. There is no specific treatment for FRDA-associated cardiomyopathy; even in advanced cardiac failure cardiac transplantation is not commonly pursued. Read More

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http://dx.doi.org/10.1016/j.jns.2017.01.027DOI Listing
April 2017
6 Reads

Early and late neurological complications of liver transplantation in pediatric patients.

Pediatr Transplant 2017 May 1;21(3). Epub 2017 Jan 1.

Department of Surgery, Faculty of Medicine, İnönü University, Malatya, Turkey.

NCs occur commonly after solid organ transplantation and affect 15%-30% of liver transplant recipients. The aim of this retrospective study was to evaluate the type and incidence of neurologic events in pediatric patients following LT. Between May 2006 and June 2015, 242 patients (118 females, 124 males) requiring LT for different etiologies at the İnönü University Liver Transplantation Institute were included. Read More

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http://dx.doi.org/10.1111/petr.12872DOI Listing
May 2017
5 Reads

Gangliocytoma Presenting With Tacrolimus Neurotoxicity in a Renal Transplant Recipient: Case Report.

Transplant Proc 2016 Nov;48(9):3142-3144

Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address:

Tacrolimus is a widely used macrolide immunosuppressant in transplant surgery, with mild and major neurologic side effects. A 21-year-old woman had undergone preemptive transplantation of a kidney from her mother. On the 1st postoperative day, the patient had headache, nausea, vomiting, and agitation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345163052
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http://dx.doi.org/10.1016/j.transproceed.2016.09.004DOI Listing
November 2016
4 Reads

[Morbidity of autologous bone harvesting in implantology: Literature review from 1990 to 2015].

Rev Stomatol Chir Maxillofac Chir Orale 2016 Dec 4;117(6):388-402. Epub 2016 Nov 4.

Clinique de chirurgie maxillo-faciale et stomatologie, CHU Hôtel-Dieu, 44093 Nantes, France.

Introduction: Autogenous bone is commonly used in pre-implant bone reconstructions. Five harvesting sites are frequently used: mandibular symphysis and ramus, iliac crest, calvaria and tibia. One of the deciding criterions among these sites is the donor site morbidity. Read More

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http://dx.doi.org/10.1016/j.revsto.2016.09.003DOI Listing
December 2016
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Venoarterial Extracorporeal Membrane Oxygenation Support as a Bridge to Heart Transplant: Report of 3 Cases.

Exp Clin Transplant 2016 11;14(Suppl 3):121-124

From the Department of Anesthesiology and Critical Care Medicine Faculty of Medicine, Baskent University Ankara, Turkey.

Heart transplant is the only definitive treatment of end-stage heart failure. Venoarterial extracorporeal membrane oxygenation may be used as a bridge to heart transplant. Among 31 patients who underwent heart transplant between January 2014 and June 2016, we present our experiences with 3 patients who received venoarterial extracorporeal support as a bridge to heart transplant. Read More

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November 2016
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Partners in Crime: Kidney Transplantation and Seizure Disorder.

Transplant Proc 2016 Oct;48(8):2700-2708

Section of Transplantation and Immunology, Department of Surgery, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address:

Seizure disorder is a common neurologic complication of kidney transplantation and often presents as a complex management challenge. Little is known about the risks mutually conferred by the 2 clinical entities and the effects of such risks on clinical outcomes. Using the National Inpatient Sample, our goal was to examine the effects of kidney transplantation and seizure disorder on mortality, hospitalization statistics, clinical complications, and cost of care. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345163041
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http://dx.doi.org/10.1016/j.transproceed.2016.06.041DOI Listing
October 2016
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Acute West Nile Virus Meningoencephalitis Diagnosed Via Metagenomic Deep Sequencing of Cerebrospinal Fluid in a Renal Transplant Patient.

Am J Transplant 2017 03 21;17(3):803-808. Epub 2016 Oct 21.

Department of Biochemistry and Biophysics, University of California, San Francisco, CA.

Solid organ transplant patients are vulnerable to suffering neurologic complications from a wide array of viral infections and can be sentinels in the population who are first to get serious complications from emerging infections like the recent waves of arboviruses, including West Nile virus, Chikungunya virus, Zika virus, and Dengue virus. The diverse and rapidly changing landscape of possible causes of viral encephalitis poses great challenges for traditional candidate-based infectious disease diagnostics that already fail to identify a causative pathogen in approximately 50% of encephalitis cases. We present the case of a 14-year-old girl on immunosuppression for a renal transplant who presented with acute meningoencephalitis. Read More

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http://dx.doi.org/10.1111/ajt.14058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347949PMC
March 2017
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[Challenges in renal transplantation].

Prog Urol 2016 Nov 6;26(15):1001-1044. Epub 2016 Oct 6.

Service d'urologie, hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France; Université Paris Descartes, 75006 Paris, France.

Objectives: To describe kidney transplantation surgical techniques and to propose strategies in high-risk recipients.

Material And Methods: Relevant publications were identified through Medline (http://www.ncbi. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11667087163056
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http://dx.doi.org/10.1016/j.purol.2016.09.056DOI Listing
November 2016
4 Reads

[Ecchymosis as the presenting manifestation of Wilson disease: A case report].

Rev Med Interne 2017 Jun 14;38(6):416-419. Epub 2016 Sep 14.

Réanimation polyvalente, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France.

Introduction: The presence of a psychiatric disorder during the course of an organic disease is a common cause of delayed diagnosis.

Case Report: We report a 16-year-old girl who was admitted with thrombocytopenia and had a two-year history of neuropsychiatric disorder which was attributed to a difficult family situation. Neurological examination showed a frontal lobe disorder and extrapyramidal manifestations. Read More

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http://dx.doi.org/10.1016/j.revmed.2016.08.010DOI Listing
June 2017
3 Reads

[Allogeneic hematopoietic stem cell transplantation associated thrombotic microangiopathy: 16 cases report and literature review].

Zhonghua Xue Ye Xue Za Zhi 2016 Aug;37(8):666-70

The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.

Objective: To analyze the clinical characteristics, treatment and prognosis of 16 allogeneic hematopoietic stem cell transplantation (allo- HSCT)- associated thrombotic microangiopathy (TA- TMA) patients.

Methods: The clinical data of 16 TA- TMA cases in 852 patients following allo- HSCT from Jan. 2013 to Jun. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2016.08.007DOI Listing
August 2016
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Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis.

Neurology 2016 Aug 27;87(8):773-81. Epub 2016 Jul 27.

From the Departments of Medicine (Neurology and Rheumatology) (Y.S., M.Y., N.E., T.Y., S.-i.I.) and Brain Disease Research (M.Y.), Shinshu University School of Medicine; Institute for Biomedical Sciences (Y.S., M.Y., S.-i.I.), Shinshu University; Jisenkai Brain Imaging Research Center (Y.S., K.O.); Departments of Neurology (H.Y.) and Pathology (M.W.), Nagano Red Cross Hospital; and Department of Dementia and Higher Brain Function (F.K.), Tokyo Metropolitan Institute of Medical Science, Japan.

Objective: To investigate the prevalence and clinical features of posttransplant CNS symptoms in patients with hereditary ATTR amyloidosis and their Pittsburgh compound B (PiB)-PET imaging correlates.

Methods: We monitored prevalence and type of CNS symptoms in 53 consecutive posttransplant patients with hereditary ATTR amyloidosis. (11)C-PiB-PET was performed in 15 patients with various disease durations. Read More

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http://dx.doi.org/10.1212/WNL.0000000000003001DOI Listing
August 2016
33 Reads

Mechanical Circulatory Support as Bridge to Transplantation for the Failing Single Ventricle.

Ann Thorac Surg 2017 Jan 15;103(1):193-197. Epub 2016 Jul 15.

Department of Cardiac Surgery, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Circulatory failure necessitating cardiac transplantation will ultimately develop in many patients with functional single-ventricle physiology. Interest in the use of mechanical circulatory support (MCS) in this population is growing.

Methods: This was a retrospective case series of patients with functional single-ventricle physiology who underwent MCS with a ventricular assist device or a total artificial heart as a bridge to cardiac transplantation between January 2006 and December 2014. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2016.05.015DOI Listing
January 2017
16 Reads