13,407 results match your criteria Neurologia i neurochirurgia polska[Journal]


Topography of 11C-Pittsburgh compound B uptake in Alzheimer's disease: a voxel-based investigation of cortical and white matter regions.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Núcleo de Apoio à Pesquisa em Neurociência Aplicada (NAPNA), USP, São Paulo, SP, Brazil.

Objective: To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer's disease (AD), and explore possible group differences in 11C-PIB binding to white matter.

Methods: 11C-PIB PET scans were acquired from subjects with AD (n=17) and healthy elderly controls (n=19). Voxel-based analysis was performed with statistical parametric mapping (SPM). Read More

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December 2018

Deficits in Emotion Recognition as Markers of Frontal Behavioral Dysfunction in Amyotrophic Lateral Sclerosis.

J Neuropsychiatry Clin Neurosci 2018 Dec 12:appineuropsych18040086. Epub 2018 Dec 12.

From the Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Martins, Prado, Teixeira, de Souza); Programa de Pós-Graduação em Neurociências, da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Prado, Teixeira, de Souza); the Departamento de Neurología Sur/Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile (Lillo); the Geroscience Center for Brain Health and Metabolism, Santiago, Chile (Lillo); the School of Health Sciences, University of East Anglia, Norwich, United Kingdom (Mioshi); and the Department of Internal Medicine, Faculdade de Medicina, da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (Teixeira, de Souza).

Objective:: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with prominent motor symptoms. Patients with ALS may also manifest frontal behavior symptoms and cognitive decline, including impairment in facial emotion recognition. The authors aimed to investigate whether deficits in emotion recognition were associated with frontal behavior symptoms in ALS. Read More

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December 2018

[Spontaneous remission of acromegaly and Cushing's disease in older patients. Report of two cases].

Rev Med Chil 2018 Jul;146(7):933-937

Departamento de Neurología y Neurocirugía, Hospital Clínico de la Universidad de Chile, Santiago, Chile.

Pituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. Read More

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July 2018
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[Impacto en el desenlace funcional en pacientes con ictus: experiencia de una unidad de cuidados neurovasculares].

Gac Med Mex 2018 ;154(Supp 2):S56-S60

GECEN Investigators: Humberto Leal-Bailey, Mezli Espinosa-Ortega, Nicolás Escobedo-Zuñiga, Denisse Martínez-Roque y Mario Cristóbal-Niño.

Background And Objective: Neurovascular care units (NCU) have a positive impact on the functional prognosis of stroke patients. The effectiveness of NCUs in Mexico has not been evaluated. Our objective was to determine the impact of an NCU in a third-level academic hospital in northeastern of Mexico. Read More

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January 2018

Diagnostic Utility of [11C]DTBZ Positron Emission Tomography In Clinically Uncertain Parkinsonism: Experience of a Single Tertiary Center.

Rev Invest Clin 2018 ;70(6):285-290

Movement Disorders Clinic. Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.

Background: The use of single-photon emission computed tomography and positron emission tomography (PET) has proven to be helpful in differentiating Parkinson's disease (PD) from other movement disorders with a sensitivity of up to 95%.

Objective: The objective of this study was to determine the accuracy of [11C]DTBZ PET imaging in patients with clinically uncertain parkinsonism from a tertiary referral center in Mexico City.

Materials And Methods: Patients who underwent [11C]DTBZ PET brain scan due to clinically uncertain parkinsonism where divided into two groups: PD or non-PD. Read More

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January 2018

[Breve recorrido histórico de la enfermedad de Parkinson a 200 años de su descripción].

Gac Med Mex 2018 ;154(6):719-726

Laboratorio Clínico de Enfermedades Neurodegenerativas. Secretaría de Salud, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.

The original description of what currently is known as Parkinson's disease was published 200 years ago. During both these centuries, knowledge on symptomatology, pathophysiology, genetics and pharmaceutical and surgical treatment has significantly increased; however, this nosological entity continues to be of imprecise origin and progressive evolution. In the present review, the historical events that contributed to describe and improve the understanding of this disease are summarized. Read More

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January 2018

Muscle MRI in a large cohort of patients with oculopharyngeal muscular dystrophy.

J Neurol Neurosurg Psychiatry 2018 Dec 8. Epub 2018 Dec 8.

Neuromuscular Disorders Unit, Neurology Department, Hospital de la Santa Creu I Sant Pau, Universidad Autónoma de Barcelona, Barcelona, Spain

Background And Objective: Oculopharyngeal muscular dystrophy (OPMD) is a genetic disorder caused by an abnormal expansion of GCN triplets within the gene. Previous descriptions have focused on lower limb muscles in small cohorts of patients with OPMD, but larger imaging studies have not been performed. Previous imaging studies have been too small to be able to correlate imaging findings to genetic and clinical data. Read More

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December 2018
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Human Extraparenchymal Neurocysticercosis: The Control of Inflammation Favors the Host…but Also the Parasite.

Front Immunol 2018 16;9:2652. Epub 2018 Nov 16.

Unidad de Neuroinflamación, Instituto de Investigaciones Biomédicas, UNAM/ Facultad de Medicina UNAM / Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, Mexico.

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November 2018

[Progressive myoclonic epilepsy secondary to Lafora's body disease].

Medicina (B Aires) 2018 ;78(6):436-439

Sección Epilepsia, Servicio de Neurología, Hospital Italiano Buenos Aires, Argentina. E-mail:

Lafora's disease is infrequent. However, it is one of the most common causes of progressive myoclonus epilepsy. We present the case of a 19-year-old woman, without comorbidities and normal development that started at 8 years with seizures and that from 15 years, had progressive cognitive deterioration. Read More

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January 2018

[Obstructive sleep apnea-hypopnea and stroke].

Medicina (B Aires) 2018 ;78(6):427-435

Departamento de Medicina, Universitat Autónoma de Barcelona, Barcelona, España.

Stroke, one of the main causes of disability and death worldwide, is frequently associated to the obstructive sleep apnea-hypopnea syndrome. This sleep disorder has been demonstrated to be an independent risk factor for stroke, and therefore its investigation and treatment has been recommended for patients with stroke. Mechanisms relating these two clinical disorders include: oxidative stress, cerebral blood flow alterations, autonomic dysfunction, and hypercoagulability, as well as patent foramen ovale, blood pressure, and heart rhythm disorders. Read More

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January 2018
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Analysis of cognitive performance and polymorphisms of SORL1, PVRL2, CR1, TOMM40, APOE, PICALM, GWAS_14q, CLU, and BIN1 in patients with mild cognitive impairment and cognitively healthy controls.

Neurologia 2018 Nov 29. Epub 2018 Nov 29.

Grupo de Neurociencias, Universidad Nacional de Colombia, Bogotá, Colombia; Unidad de Neurología, Hospital Universitario Nacional, Bogotá, Colombia; Instituto de Investigaciones Clínicas, Universidad Nacional de Colombia, Bogotá, Colombia.

Introduction: Alzheimer disease risk polymorphisms have been studied in patients with dementia, but have not yet been explored in mild cognitive impairment (MCI) in our population; nor have they been addressed in relation to cognitive variables, which can be predictive biomarkers of disease.

Objective: To evaluate cognitive performance and presence of polymorphisms of the genes SORL1(rs11218304), PVRL2(rs6859), CR1(rs6656401), TOMM40(rs2075650), APOE (isoforms ɛ2, ɛ3, ɛ4), PICALM(rs3851179), GWAS_14q(rs11622883), BIN1(rs744373), and CLU (rs227959 and rs11136000) in patients with MCI and healthy individuals.

Methodology: We performed a cross-sectional, exploratory, descriptive study of a prospective cohort of participants selected by non-probabilistic sampling, evaluated with neurological, neuropsychological, and genetic testing, and classified as cognitively healthy individuals and patients with MCI. Read More

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November 2018

Pleural Extramedullary Hematopoiesis due to severe pernicious anemia.

Med Clin (Barc) 2018 Nov 29. Epub 2018 Nov 29.

Servicio de Hematología, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

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November 2018

Cranial nerve disorders: clinical manifestations and topography.

Radiologia 2018 Nov 27. Epub 2018 Nov 27.

Sección de Neurorradiología, Hospital Clínico San Carlos, Madrid, España.

The detection of pathological conditions related to the twelve cranial pairs represents a significant challenge for both clinicians and radiologists; imaging techniques are fundamental for the management of many patients with these conditions. In addition to knowledge about the anatomy and pathological entities that can potentially affect the cranial pairs, the imaging evaluation of patients with possible cranial pair disorders requires specific examination protocols, acquisition techniques, and image processing. This article provides a review of the most common symptoms and syndromes related with the cranial pairs that might require imaging tests, together with a brief overview of the anatomy, the most common underlying processes, and the most appropriate imaging tests for different indications. Read More

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November 2018

Ischemic stroke and infectious diseases in low-income and middle-income countries.

Curr Opin Neurol 2018 Dec 3. Epub 2018 Dec 3.

Serviço de Neurologia, Hospital das Clínicas da Universidade Federal de Minas Gerais/EBSERH.

Purpose Of Review: To address the important relationships between stroke and infection, focusing on the most frequent infections found in low-income and middle-income countries.

Recent Findings: Stroke is one of the leading causes of mortality and disability worldwide, with a great proportion of the stroke burden occurring in low-income and middle-income countries. Infectious diseases are still a great health problem in developing countries and it is possible that the proportion of infection-related strokes is greater in these nations. Read More

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December 2018

Discontinuation of teriflunomide and dimethyl fumarate in a large Italian multicentre population: a 24-month real-world experience.

J Neurol 2018 Dec 4. Epub 2018 Dec 4.

Department "G.F. Ingrassia", MS centre University of Catania, Catania, Italy.

Background: Teriflunomide (TRF) and Dimethyl fumarate (DMF) are licensed drugs for relapsing-remitting Multiple Sclerosis (RRMS).

Objectives: We aimed to compare the rate and the time to discontinuation among persons with RRMS (pwRRMS), newly treated with TRF and DMF.

Materials And Methods: A retrospective study on prospectively collected data was performed in nine tertiary MS centers, in Italy. Read More

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December 2018

Primary School Education May Be Sufficient to Moderate a Memory-Hippocampal Relationship.

Front Aging Neurosci 2018 20;10:381. Epub 2018 Nov 20.

Grupo de Pesquisa em Neurologia Cognitiva e do Comportamento, Departamento de Clínica Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

According to the cognitive reserve theory, intellectual stimuli acquired during life can prevent against developing cognitive impairment. The underlying cognitive reserve mechanisms were underexplored in low-educated individuals. Because episodic memory impairment due to hippocampal dysfunction is a key feature of Alzheimer's dementia (AD), we sought to look at a possible cognitive reserve mechanism by determining whether few years of education moderated the relationship between the hippocampal volumes and the episodic-memory scores. Read More

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November 2018
2 Reads

Prevalence and Causes of Cognitive Impairment and Dementia in a Population-Based Cohort From Northern Portugal.

Am J Alzheimers Dis Other Demen 2018 Dec 4:1533317518813550. Epub 2018 Dec 4.

1 EPIUnit-Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Background:: Vascular disease may play an important role in the epidemiology of dementia in countries with high stroke incidence, such as Portugal.

Objective:: To assess the prevalence and etiology of cognitive impairment in a population-based cohort from Portugal.

Methods:: Individuals ≥55 years (n = 730) from the EPIPorto cohort were assessed using the Mini-Mental State Examination and the Montreal Cognitive Assessment. Read More

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December 2018
1 Read

Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury.

Ann N Y Acad Sci 2018 Nov 29. Epub 2018 Nov 29.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Sepsis occurs when a systemic infection induces an uncontrolled inflammatory response that results in generalized organ dysfunction. The exacerbated peripheral inflammation can induce, in turn, neuroinflammation which may result in severe impairment of the central nervous system (CNS). Indeed, the ensuing blood-brain barrier disruption associated with sepsis promotes glial activation and starts a storm of proinflammatory cytokines in the CNS that leads to brain dysfunction in sepsis survivors. Read More

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November 2018

Autophagic and Apoptotic Pathways as Targets for Chemotherapy in Glioblastoma.

Int J Mol Sci 2018 Nov 27;19(12). Epub 2018 Nov 27.

Departamento de Neuroinmunología, Laboratorio de Neurobiología Molecular y Celular, Laboratorio Experimental de Enfermedades Neurodegenerativas del Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", C.P. 14269 Ciudad de México, Mexico.

Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a mean life expectancy of less than 15 months. This is due in part to the high resistance to apoptosis and moderate resistant to autophagic cell death in glioblastoma cells, and to the poor therapeutic response to conventional therapies. Autophagic cell death represents an alternative mechanism to overcome the resistance of glioblastoma to pro-apoptosis-related therapies. Read More

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November 2018
3 Reads

The use of cobalt chloride as a chemical hypoxia model.

J Appl Toxicol 2018 Nov 28. Epub 2018 Nov 28.

Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurología (INNN), Insurgentes Sur 3877, la Fama, 14269, Tlalpan Ciudad de México, Mexico.

The use of hypoxia models in cell culture has allowed the characterization of the hypoxia response at the cellular, biochemical and molecular levels. Although a decrease in oxygen concentration is the optimal hypoxia model, the problem faced by many researchers is access to a hypoxia chamber or a CO incubator with regulated oxygen levels, which is not possible in many laboratories. Several alternative models have been used to mimic hypoxia. Read More

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November 2018

[«Apuntes en Neurologia» (Notes in Neurology): a synthesis of the evidence on common paroxysmal neurological disorders and on neurodegenerative disorders].

Rev Neurol 2018 Nov;67(s01):S1-S21

Hospital La Fe, 46009 Valencia, Espana.

«Apuntes en Neurologia» is an initiative in which prominent national and international leaders, with broad academic recognition, came together to synthesise the most outstanding clinical aspects within their area of interest and to discuss the latest developments in a more accessible language. Understanding the factors that affect the onset and progression of any neurological disease through a review is important to be able to develop strategies to reduce the burden of these diseases. Moreover, knowledge of the clinical aspects is essential to solve the problems of daily clinical practice. Read More

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November 2018
2 Reads

A case report of an intramedullary cervical teratoma in an adult patient with cervical spondylotic radiculopathy.

Neurocirugia (Astur) 2018 Oct 25. Epub 2018 Oct 25.

Servicio de Neurocirugía, Módulo de Columna, Hospital Regional 1° de Octubre, ISSSTE, Mexico City, Mexico.

Spinal cord teratomas are rare. There are few reports of teratomas affecting the cervical spine and their association with spondylotic radiculopathy has not been described. A 59-year-old woman with history of fecal incontinence attended with cervical radicular pain radiating to upper limbs. Read More

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October 2018
1 Read

Neuroimaging in dementia. Clinical-radiological correlation.

Radiologia 2018 Oct 25. Epub 2018 Oct 25.

Departamento de Neurología, Hospital Ruber Internacional, Madrid, España.

Dementia is a syndrome characterised by chronic, multi-domain, acquired cognitive impairment that causes significant functional limitations. MRI is the standard imaging study for these cases, since it enables detection of the atrophy patterns of the various neurodegenerative diseases (Alzheimer's disease, frontotemporal degeneration, Lewy body dementia), the vascular lesions associated with vascular dementia, and various potentially reversible diseases (for example, tumours, hydrocephaly) or diseases that require special management measures (for example, prion diseases). In certain cases other imaging methods can be used, such as CT, functional MRI, HMPAO SPECT or dopaminergic markers and FDG PET, amyloid markers or dopaminergic markers. Read More

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October 2018
3 Reads

Stroke Longitudinal Volumetric Measures Correlate with the Behavioral Score in Non-Human Primates.

Neuroscience 2018 Nov 24;397:41-55. Epub 2018 Nov 24.

Centre for Neuroscience studies, Queen's University, Kingston, Canada; Translational Stroke Research Lab, Department of Surgery, Faculty of Health Sciences, Queen's University, Kingston, Canada. Electronic address:

Stroke is the second leading cause of death worldwide. Brain imaging data from experimental rodent stroke models suggest that size and location of the ischemic lesion relate to behavioral outcome. However, such a relationship between these two variables has not been established in Non-Human Primate (NHP) models. Read More

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November 2018
2 Reads

Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis.

Ann Clin Transl Neurol 2018 Nov 23;5(11):1362-1371. Epub 2018 Sep 23.

Dr. John T. Macdonald Department of Human Genetics Miller School of Medicine University of Miami Miami Florida.

Background And Objective: Hispanics with multiple sclerosis (MS) present younger and more often with optic neuritis (ON) as compared to Whites in the western United States. Regional differences related to Hispanic genetic admixture could be responsible. We investigated the association between global genetic ancestry and ON and age at onset of MS in Hispanics. Read More

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November 2018
2 Reads

Current understanding of the mixed pain concept: a brief narrative review.

Curr Med Res Opin 2018 Nov 27:1-16. Epub 2018 Nov 27.

q Pain Center, Department of Neurology, Hospital das Clinicas FMUSP , São Paulo , Brazil.

Despite having been referenced in the literature for over a decade, the term 'mixed pain' has never been formally defined. The strict binary classification of pain as being either purely neuropathic or nociceptive once left a good proportion of patients unclassified; even the recent adoption of 'nociplastic pain' in the IASP Terminology leaves out patients who present clinically with a substantial overlap of nociceptive and neuropathic symptoms. For these patients, the term 'mixed pain' is increasingly recognized and accepted by clinicians. Read More

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November 2018
1 Read

Coronary vasodilation impairment in pilocarpine model of epilepsy.

Epilepsy Behav 2018 Nov 23;90:7-10. Epub 2018 Nov 23.

Department of Physiological Sciences, Integrative Laboratory of Cardiovascular and Neurological Pathophysiology, Federal University of Goiás, Goiânia, GO, Brazil. Electronic address:

We investigated the coronary arteries reactivity alterations in rats with epilepsy induced by pilocarpine. To do so, male Wistar rats weighing between 250 g and 300 g were used. Status epilepticus (SE) was induced in rats using 385 mg/kg (i. Read More

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November 2018
2 Reads

Interferon-beta treated-multiple sclerosis patients exhibit a decreased ratio between immature/transitional B cell subset and plasmablasts.

J Neuroimmunol 2018 Nov 16;326:49-54. Epub 2018 Nov 16.

Unidade de Gestão Operacional de Citometria, Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Praceta Mota Pinto, 3001-301 Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculdade de Medicina, Universidade de Coimbra, Polo III - Health Sciences Campus Azinhaga Santa Comba, Celas, 3000-548 Coimbra, Portugal; Escola Superior de Tecnologia da Saúde de Coimbra, Rua 5 de Outubro, 3046-854 Coimbra, Portugal. Electronic address:

Our aim was to quantify circulating B cell subsets; immature/transitional, naïve, CD27 and CD27 memory cells and plasmablasts, in relapsing-remitting multiple sclerosis patients treated with IFN-β. The most relevant findings were a significant increase of plasmablasts and a decrease of immature/transitional B cells, resulting in a decreased ratio between those cells in relapse RRMS, together with an increase of CD27 and CD27IgM memory B cell subsets in both phases of the disease. These alterations point to an active B cell response, particularly in relapse, and the above referred ratio could constitute a good biomarker of relapse in patients that underwent IFN-β treatment. Read More

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November 2018
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Factors Associated With Cysticidal Treatment Response in Extraparenchymal Neurocysticercosis.

J Clin Pharmacol 2018 Nov 26. Epub 2018 Nov 26.

Neuroinflammation Unit, IIBM-UNAM/INNN/Facultad de Medicina- UNAM, Ciudad de México, México.

Extraparenchymal neurocysticercosis is the most severe form of cysticercosis, and response to treatment is suboptimal. We sought to determine how demographic and clinical characteristics and albendazole sulfoxide concentrations were related to cysticidal treatment response. We conducted a longitudinal study of 31 participants with extraparenchymal vesicular parasites who received the same treatment, albendazole 30 mg/kg/day for 10 days with dexamethasone 0. Read More

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November 2018
4 Reads

Yield of Echocardiography in the Evaluation of Cerebral Ischemic Events: A Single Center Cohort Study.

J Stroke Cerebrovasc Dis 2018 Nov 22. Epub 2018 Nov 22.

Unidad de Neurología Vascular, Servicio de Neurología, Departamento de Neurología y Psiquiatría y Departamento Paciente Crítico, Clínica Alemana de Santiago. Facultad de Medicina, Universidad del Desarrollo, Santiago and Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Background: Echocardiography (ECO) is frequently used as a screening test in patients with acute ischemic brain disease. We aimed to evaluate the additional information and therapeutic impact resulting from ECO in these patients.

Methods: We conducted a prospective study performing ECO on consecutive patients with ischemic stroke or transient ischemic attacks, admitted to our centre between February 2013 and May 2017. Read More

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November 2018
5 Reads

Multiple intracranial meningiomas: a case series and review of the literature.

World Neurosurg 2018 Nov 21. Epub 2018 Nov 21.

Departamento de Neurologia do Hospital das Clínicas da Universidade de São Paulo-SP, Brasil.

Objective: Review the data published on the subject to create a more comprehensive natural history of multiple meningiomas (MM).

Methods: a review of the MM published in the literature up to now was carried out through a Medline search up to August 2018. The use of the "multiple meningiomas" keyword returned 278 papers; and the parameters analyzed in our present cohort were searched on those publications. Read More

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November 2018
7 Reads

"Stroke-like" events after brain radiotherapy: a large series with long-term follow-up.

Eur J Neurol 2018 Nov 24. Epub 2018 Nov 24.

Neuroncology Unit, IRCCS Mondino Foundation, Pavia, Italy.

Background: Patients with history of brain radiotherapy can experience acute "stroke-like" syndromes related to the delayed effects of brain radiation, including "Stroke-like Migraine Attacks after Radiation Therapy (SMART)", "Peri-Ictal Pseudoprogression (PIPG)", and "Acute Late-onset Encephalopathy after Radiation Therapy (ALERT)" syndrome. The aim of this study is to collect evidence on the long-term outcome and treatment of these conditions, whose knowledge is undermined by their rarity and fragmented description.

Methods: Cases were collected, both prospectively and retrospectively, among six neuro-oncology departments. Read More

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November 2018
10 Reads

Vertebral hemangiomatosis as atipic cause of acute myelopathy.

Med Clin (Barc) 2018 Nov 20. Epub 2018 Nov 20.

Servicio de Cirugía, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España. Electronic address:

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November 2018
1 Read

Tocilizumab in MOG-antibody spectrum disorder: a case report.

Mult Scler Relat Disord 2018 Nov 13;27:312-314. Epub 2018 Nov 13.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Unit, Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy; Ospedale Policlinico San Martino-IRCCS, Genoa, Italy. Electronic address:

Background: Myelin oligodendrocyte glycoprotein antibody-related spectrum disorders (MOG-SD) are a heterogeneous group of inflammatory demyelinating diseases of the central nervous system, usually responsive to conventional immunosuppressive therapies. However, knowledge about treatment of non-responder patients is scarce.

Methods: We report on a 20-year-old MOG-SD patient who experienced clinical deterioration despite rituximab-induced B-cell depletion. Read More

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November 2018
2 Reads

Melatonin in sleep disorders.

Neurologia 2018 Nov 19. Epub 2018 Nov 19.

Unidad Multidisciplinar de Sueño, Hospital Universitario Vall d́Hebron, Barcelona, España.

Melatonin is the main hormone involved in the control of the sleep-wake cycle. It is easily synthesisable and can be administered orally, which has led to interest in its use as a treatment for insomnia. Moreover, as production of the hormone decreases with age, in inverse correlation with the frequency of poor sleep quality, it has been suggested that melatonin deficit is at least partly responsible for sleep disorders. Read More

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November 2018
1 Read

[Programa de detección del alelo APOE-E4 en adultos mayores mexicanos con deterioro cognitivo].

Gac Med Mex 2018 ;154(5):555-560

Secretaría de Salud, Instituto Nacional de Medicina Genómica, Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Ciudad de México, México.

Introduction: In Mexico, the prevalence of neurocognitive disorders (NCDs) has increased in parallel with the increase in life expectancy. The E4 allele of the gene that encodes apolipoprotein E (APOE) is the main genetic risk factor for cognitive impairment.

Objective: To replicate the association of APOE-E4 allele with neurocognitive impairment in a Mexican population, as well as to implement a genetic risk-detection program with the APOE-E4 allele. Read More

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January 2018
2 Reads

From gestalt to gene: early predictive dysmorphic features of PMM2-CDG.

J Med Genet 2018 Nov 21. Epub 2018 Nov 21.

Genetics and Molecular Medicine Department and Pediatric Institute of Rare Diseases (IPER), Hospital Sant Joan de Déu, Barcelona, Spain.

Introduction: Phosphomannomutase-2 deficiency (PMM2-CDG) is associated with a recognisable facial pattern. There are no early severity predictors for this disorder and no phenotype-genotype correlation. We performed a detailed dysmorphology evaluation to describe facial gestalt and its changes over time, to train digital recognition facial analysis tools and to identify early severity predictors. Read More

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November 2018
1 Read

Passage of Borrelia burgdorferi through diverse Ixodid hard ticks causes distinct diseases: Lyme borreliosis and Baggio-Yoshinari syndrome.

Clinics (Sao Paulo) 2018 Nov 14;73:e394. Epub 2018 Nov 14.

Reumatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Baggio-Yoshinari syndrome is an emerging, tick-borne, infectious disease recently discovered in Brazil. This syndrome is similar to Lyme disease, which is common in the United States of America, Europe and Asia; however, Brazilian borreliosis diverges from the disease observed in the Northern Hemisphere in its epidemiological, microbiological, laboratory and clinical characteristics. Polymerase chain reaction procedures showed that Baggio-Yoshinari syndrome is caused by the Borrelia burgdorferi sensu stricto spirochete. Read More

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November 2018
9 Reads

Congenital heart disease: New challenges.

Authors:
Isabel Santana

Rev Port Cardiol 2018 Nov 17;37(11):933-934. Epub 2018 Nov 17.

Serviço de Neurologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal. Electronic address:

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November 2018
1 Read

Development of a screening tool to assess dehydration in hospitalized older population: a diagnostic, observational study.

Prof Inferm 2018 Jul- Sep;71(3):178-187

RN, MsN, PhD, Esperto di ricerca infermieristica clinica, Istituto Oncologico della Svizzera Italiana, Ente Ospedaliero Cantonale, Bellinzona, CH. Corrispondence: Loris Bonetti, PhD, RN, MsN Esperto di ricerca infermieristica clinica. Ufficio Ricerca Infermieristica e Sviluppo, Istituto Oncologico della Svizzera Italiana (IOSI) Ospedale San Giovanni e Valli, Ente Ospedaliero Cantonale Via Ospedale, 26 6500 Bellinzona, CH Tel. +41 - (0)91 / 811 8957 e-mail:

Introduction: dehydration is a frequent condition in older people and is associated with an increased risk of negative health outcomes. In order to adopt strategies to prevent complications, an early recognition of this status is of primary importance. For this reason, a comprehensive assessment tool to monitor hydration status in older people could be useful. Read More

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November 2018

Perception of the validity of the Migraine Disability Assessment questionnaire in a population of patients with chronic migraine.

Neurologia 2018 Nov 16. Epub 2018 Nov 16.

Servicio de Neurología, Hospital Universitario Virgen de la Salud, Elda, Alicante, España.

Objectives: The Migraine Disability Assessment (MIDAS) questionnaire is the most frequently used instrument for assessing the level of disability in studies into migraine. This study aims to determine the level of completion of the questionnaire, assess the ease of use, and understand patients' subjective perception of the questionnaire's actual ability to measure disability.

Material And Methods: We performed a prospective study of a sample of 78 patients with chronic migraine, determining their level of education and employment status. Read More

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November 2018
3 Reads

Environmental enrichment restores oxidative balance in animals chronically exposed to toluene: Comparison with melatonin.

Brain Res Bull 2018 Nov 16;144:58-67. Epub 2018 Nov 16.

Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Ciudad de México, C.P. 11340, Mexico; Laboratorio Integrativo para el Estudio de Sustancias Inhalables Adictivas, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México Xochimilco 101, Ciudad de México, C.P. 14370, Mexico. Electronic address:

Inhalants are widely used as recreational drugs, and toluene is the main chemical compound present in most inhalants used for these purposes. Previous studies have shown that repeated toluene exposure produces cellular death and memory impairment, while environmental enrichment (EE) rescues from those effects. However, the mechanisms involved in those responses are unclear. Read More

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November 2018

Long-Term Severe Mental Disorders Preceding Behavioral Variant Frontotemporal Dementia: Frequency and Clinical Correlates in an Outpatient Sample.

J Alzheimers Dis 2018 Nov 15. Epub 2018 Nov 15.

Grupo de Pesquisa em Neurologia Cognitiva e do Comportamento, Departamento de Clínica Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.

Background: The behavioral variant frontotemporal dementia (bvFTD) shares some clinical features with severe mental disorders, such as bipolar affective disorder (BAD), schizophrenia (SCZ), and schizoaffective disorder (SZA), and at least for a small subgroup of patients, these conditions may share similar pathological genetic mutations.

Objectives: To investigate the frequency of a past medical history satisfying diagnostic criteria for BAD, SCZ, and SZA in a bvFTD outpatient sample, and to compare the clinical profile of patients with and without a positive history.

Methods: Cross-sectional study in which participants were consecutively selected after receiving a diagnosis of probable bvFTD and had a caregiver interviewed with SCID-I. Read More

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November 2018
8 Reads

Observational pilot study of patients with carpal tunnel syndrome treated with Nucleo CMP Forte™.

Pain Manag 2018 Nov 19. Epub 2018 Nov 19.

Servicio de Neurología y Neurofisiología, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Aim: Carpal tunnel syndrome (CTS) is a very common entrapment neuropathy characterized by pain and paresthesia in the territory of the median nerve. Although this syndrome has a considerable impact on the patient's quality of life, its medical treatment is far from optimal.

Material & Methods: We performed an observational study to evaluate Nucleo CMP Forte in patients with electromyography-confirmed, mild-moderate CTS. Read More

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November 2018
2 Reads

Correction to: Selective Forces Related to Spinocerebellar Ataxia Type 2.

Cerebellum 2018 Nov 19. Epub 2018 Nov 19.

Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

The original version of this article unfortunately contained a mistake. The spelling of the surname of one co-author from the publication entitled "Selective Forces Related to Spinocerebellar Ataxia Type 2" that was recently published in the journal "The Cerebelum" was incorrect. Read More

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November 2018

Chorea following extracorporeal circulation in adults: A case report and brief literature review.

Neurologia 2018 Nov 15. Epub 2018 Nov 15.

Servicio de Neurología y Unidad de Trastornos del Movimiento, Hospital Universitario La Paz, Madrid, España.

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November 2018
2 Reads

Effect of exposure to low doses of ozone on interleukin 17A expression during progressive neurodegeneration in the rat hippocampus.

Neurologia 2018 Nov 14. Epub 2018 Nov 14.

Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México. Electronic address:

Introduction: Chronic exposure to low doses of ozone causes oxidative stress and loss of regulation of the inflammatory response, leading to progressive neurodegeneration.

Objective: We studied the effect of chronic exposure to low doses of ozone on IL-17A concentration and expression in neurons, microglia, astrocytes, and T cells in the rat hippocampus.

Methods: We used 72 Wistar rats, divided into 6 groups (n=12): a control group (no ozone exposure) and 5 groups exposed to ozone (0. Read More

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November 2018
7 Reads

Effectiveness of mirror therapy in phantom limb pain: A literature review.

Neurologia 2018 Nov 14. Epub 2018 Nov 14.

Departamento de Biología Funcional y de Ciencias de la Salud, Universidad de Vigo, Pontevedra, España; Grupo de investigación HealthyFit (GHi22), Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, España. Electronic address:

Introduction: Phantom limb pain (PLP) is a type of neuropathic pain that affects the territory of an amputated limb or other surgically removed body parts. Between 60% and 90% of amputees suffer from PLP during follow-up. There are a range of therapeutic options for PLP, both pharmacological (gabapentin, amitriptyline, tricyclic antidepressants, etc) and non-pharmacological (transcutaneous electrical nerve stimulation, hypnosis, acupuncture, etc). Read More

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November 2018
3 Reads

Mild encephalopathy/encephalitis with a reversible splenial lesion associated with acute pyelonephritis: A case report.

Neurologia 2018 Nov 13. Epub 2018 Nov 13.

Unidad de Neuropediatría, Departamento de Pediatría, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal.

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November 2018
1 Read

Low levels of alpha-synuclein in peripheral tissues are related to clinical relapse in relapsing-remitting multiple sclerosis: a pilot cross-sectional study.

J Neurol Sci 2018 Nov 3;396:87-93. Epub 2018 Nov 3.

Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico. Electronic address:

The protein alpha-synuclein (α-Syn) has been linked to neuroinflammatory conditions. We investigated whether the presence of α-Syn in peripheral tissues is a surrogate of brain inflammatory status in a small group of relapsing-remitting multiple sclerosis (RRMS) patients in a pilot cross-sectional study. Skin biopsies and peripheral blood were sampled from 34 healthy controls and 23 MS patients for measurement of α-Syn levels. Read More

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November 2018
3 Reads