127,330 results match your criteria Neuroleptic Malignant Syndrome


Association between use of antiemetics, antipsychotics, or antidepressants and the risk of Parkinson's disease
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Int J Clin Pharmacol Ther 2018 Dec 11. Epub 2018 Dec 11.

Objective: Antipsychotics, antidepressants, and antiemetics are well-known causative agents of parkinsonism. However, it is not certain that the use of these medications increases the risk of Parkinson's disease (PD). We aim to define the risk of PD associated with use of antipsychotic, antidepressant, or antiemetic therapy. Read More

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December 2018

Recognition, Assessment, and Pharmacotherapeutic Treatment of Alcohol Withdrawal Syndrome in the Intensive Care Unit.

Crit Care Nurs Q 2019 Jan/Mar;42(1):12-29

Department of Pharmacy Services, UC Health-University of Cincinnati Medical Center, Ohio (Drs Foertsch, Winter, Droege, and Ernst); University of Cincinnati James L. Winkle College of Pharmacy, Ohio (Drs Foertsch, Winter, Rhoades, Martin, Droege, and Ernst); Department of Pharmacy Services, The Christ Hospital Health Network, Cincinnati, Ohio (Dr Rhoades); and Department of Pharmacy Services, St Elizabeth Healthcare, Edgewood, Kentucky (Dr Martin).

Alcohol withdrawal syndrome (AWS) is a complex neurologic disorder that develops after an acute reduction in or cessation of chronic alcohol consumption that alters neurotransmitter conduction. The incidence of AWS in the intensive care unit varies, but has been associated with poor outcomes. This is primarily driven by downregulation of gamma-aminobutyric acid (GABA) leading to autonomic excitability and psychomotor agitation. Read More

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December 2018

Neuroleptic malignant syndrome: evaluation of drug safety data from the AMSP program during 1993-2015.

Eur Arch Psychiatry Clin Neurosci 2018 Nov 30. Epub 2018 Nov 30.

University Clinic for Psychiatry and Psychotherapy, Brandenburg Medical School, Immanuel Klinik Rüdersdorf, Seebad 82/83, 15562, Rüdersdorf bei Berlin, Germany.

Neuroleptic malignant syndrome (NMS) is a rare, but severe adverse drug reaction of drugs with anti-dopaminergic properties. The main symptoms are fever and rigor. In addition, other symptoms such as creatine kinase elevation, alteration of consciousness and various neurological symptoms may occur. Read More

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November 2018
1 Read

Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.

Bosn J Basic Med Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Phenibut is a glutamic acid derivative with activity on the γ-aminobutyric acid (GABA) B and A, and β-phenethylamine receptors. It is prescribed in former Communist Bloc countries for anxiolysis and related psychiatric disorders. It can be easily obtained in Western countries, and is thought to have abuse potential. Read More

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December 2018
2 Reads

Diagnostic Validation for Participants in the Washington State Parkinson Disease Registry.

Parkinsons Dis 2018 1;2018:3719578. Epub 2018 Nov 1.

Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

Background: The Washington State Parkinson Disease Registry (WPDR) was created to facilitate recruitment for Parkinson's disease (PD) research studies conducted in the Pacific Northwest. The success of registries that rely on self-report is dependent on the accuracy of the information provided by participants, particularly diagnosis.

Objective And Methods: Our goal was to assess diagnostic accuracy within the WPDR cohort. Read More

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November 2018
2 Reads

Revisiting the Concept of Subjective Tolerability to Antipsychotic Medications in Schizophrenia and its Clinical and Research Implications: 30 Years Later.

Authors:
A George Awad

CNS Drugs 2018 Dec 3. Epub 2018 Dec 3.

Professor Emeritus, Department of Psychiatry and the Institute of Medical Science, Humber River Hospital, University of Toronto, 1235 Wilson Avenue, Toronto, ON, M3M 0B2, Canada.

Schizophrenia is a long-term psychiatric disorder that impacts important mental functions and requires indefinite treatment, as well as psychosocial and economic support. The introduction of chlorpromazine, the first antipsychotic, and the subsequent development of a long list of similar dopamine-blocking antipsychotic medications, has changed the treatment of schizophrenia as medications have become the cornerstone of clinical management. The enthusiasm that greeted the introduction of antipsychotics was soon tempered by the realisation that they induced significant side effects, such as extrapyramidal and autonomic symptoms. Read More

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December 2018
1 Read

Evaluation of blood-brain barrier penetration and examination of binding to human serum albumin of 7-O-arylpiperazinylcoumarins as potential antipsychotic agents.

Bioorg Chem 2018 Nov 22;84:211-225. Epub 2018 Nov 22.

Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland. Electronic address:

The delivery of drugs to the brain is complicated by the multiple factors including low blood-brain barrier (BBB) passive permeability, active BBB efflux systems, and plasma protein binding. Thus, a detailed understanding of the transport of the new potent substances through the membranes is vitally important and their physico-chemical characteristics should be analyzed at first. This work presents an evaluation of drug likeness of eight 7-O-arylpiperazinylcoumarin derivatives with high affinity towards serotoninergic receptors 5-HT and 5-HT with particular analysis of the requirements for the CNS chemotherapeutics. Read More

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November 2018

Psychopharmacological prescribing practices in pregnancy for women with severe mental illness: A multicentre study.

Eur Neuropsychopharmacol 2018 Nov 26. Epub 2018 Nov 26.

Mercy Hospital for Women, Heidelberg, Australia.

There is little known about real world psychopharmacological prescribing practices in managing pregnant women with severe mental illness (SMI). This study utilised a sample of 535 women with a SMI across two hospitals in Australia. This included women with psychotic disorders, bipolar disorder and a range of non-psychotic disorders. Read More

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November 2018
4 Reads

Patterns of Management of Patients With Dual Disorder (Psychosis) in Italy: A Survey of Psychiatrists and Other Physicians Focusing on Clinical Practice.

Front Psychiatry 2018 13;9:575. Epub 2018 Nov 13.

Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.

Patients with severe psychotic disorders such as schizophrenia, schizoaffective, and bipolar disorders frequently suffer from concomitant substance use disorders (SUDs)-Dual Disorder (DD) patients. In order to better understand current practices for management of patients with psychotic episodes and concomitant SUD in Italy, we carried out a survey of psychiatrists on current routine practice among prescribers. These aspects can help to identify at-risk patients, improve current prescribing practices, and favor early intervention. Read More

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November 2018
1 Read

The effects of different periods of co-administration of oral and long-acting injectable aripiprazole: A propensity score analysis.

Hum Psychopharmacol 2018 Nov 27:e2681. Epub 2018 Nov 27.

Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.

Objective: Long-acting injectable (LAI) aripiprazole is recommended to be combined with oral aripiprazole for 2 weeks after its introduction. However, we often experience patients who require more than 2 weeks of combined use. Therefore, differences in combination periods need to be examined. Read More

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November 2018
1 Read

Aripiprazole for the Treatment of Inappropriate Sexual Behavior: Case Report of an Alzheimer's Disease Patient Known as Heterosexual with Recently Shifted Sexual Orientation to Same Gender.

J Alzheimers Dis Rep 2018 Jun 29;2(1):117-121. Epub 2018 Jun 29.

Department of Radiology, Neuroradiology, Yeditepe University Medical Faculty, Istanbul, Turkey.

Although inappropriate sexual behavior in dementia is not common, it can be extremely troublesome for healthcare professionals and caregivers as well as patients themselves. There is paucity of data in the literature for the management of these behaviors, but the limited available data suggest efficiency of some commonly used treatment modalities. Herein, we present a 74-year old Alzheimer's disease (AD) patient, known to be heterosexual throughout her past life, presenting with a recent display of same-sex inappropriate sexual behavior six years after the initial diagnosis of her disease. Read More

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June 2018
1 Read

Increased All-Cause Mortality by Antipsychotic Drugs: Updated Review and Meta-Analysis in Dementia and General Mental Health Care.

J Alzheimers Dis Rep 2018 Feb 2;2(1):1-26. Epub 2018 Feb 2.

School of Medicine, Griffith University, Gold Coast, Southport, QLD, Australia.

It is almost ten years since the Banerjee 2009 report established that inappropriate prescribing of antipsychotics in the elderly was occurring in the UK and such patients had an 85% increased risk of adverse events and greater mortality. This report was a critical analysis addressing the outcomes of treatment practices for dementia in UK patients and globally, aimed at reducing prescribing of antipsychotic drugs for dementia. Since 2009, many significant studies worldwide (including several more recent large retrospective studies) provide more extensive longitudinal data for the adverse impacts of antipsychotic drugs in dementia. Read More

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February 2018
1 Read

A Comparison of Early, Late, and No Treatment of Intensive Care Unit Delirium With Antipsychotics: A Retrospective Cohort Study.

Prim Care Companion CNS Disord 2018 Nov 15;20(6). Epub 2018 Nov 15.

Brigham and Women's Hospital, Boston, Massachusetts, USA.

Objective: To investigate the effect of early versus late versus no antipsychotic administration on intensive care unit (ICU) delirium.

Methods: This retrospective cohort study was conducted in 2 adult medical ICUs at a single tertiary care center in Boston, Massachusetts, from October 1, 2015, to May 31, 2016. The study included 322 patients stratified into those who first received antipsychotics < 48 hours after first positive or unscorable (due to sedation) modified Confusion Assessment Method (CAM-ICU-m) (early), > 48 hours after first positive or unscorable CAM-ICU-m (late), and never received antipsychotics. Read More

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November 2018
2 Reads

Risk of manic switch with antidepressants use in patients with bipolar disorder in a Nigerian neuropsychiatric hospital.

S Afr J Psychiatr 2018 6;24:1215. Epub 2018 Nov 6.

Department of Psychiatry, University of Ibadan, Nigeria.

Background: Depressive disorders are common among those with bipolar affective disorder (BAD) and may necessitate the use of antidepressants. This has been suggested to precipitate manic episodes in some patients.

Objectives: This study aims to determine the prevalence of and factors associated with manic switch in patients with BAD being treated with antidepressants. Read More

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November 2018
4 Reads

Educating Nursing Home Staff in Dementia Sensitive Communication: Impact on Antipsychotic Medication Use.

J Am Med Dir Assoc 2018 Dec;19(12):1129-1132

College of Nursing, University of Iowa, Iowa City, IA.

Objectives: An educational program to enhance communication in nursing home dementia care increased person-centered communication by staff and resulted in reduced resident behavioral symptoms measured as resistiveness to care. The purpose of this analysis was to evaluate effects on resident antipsychotic medication use in participating nursing homes. The National Partnership to Improve Dementia Care set a goal of reducing antipsychotic medications in nursing homes by 15% during the study period. Read More

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December 2018

Systematic review of case reports of oropharyngeal dysphagia following the use of antipsychotics.

Gastroenterol Hepatol 2018 Nov 20. Epub 2018 Nov 20.

Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain.

Objective: The purpose of this systematic review was to examine the effect of antipsychotic medication on dysphagia based on clinical case reports.

Patients And Methods: Literature searches were performed using the electronic databases PubMed and Embase. In PubMed, we used the MeSH terms "antipsychotic agents" OR "tranquilizing agents" combined with "deglutition disorders" OR "deglutition". Read More

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November 2018

Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report.

Clin Psychopharmacol Neurosci 2018 Nov;16(4):501-504

Departments of Child Hematology and Oncology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Autoimmune hemolytic anemia is a disease characterized with destruction of erythrocytes as a result of antibody produce against patient's own erythrocytes and anemia. Autoimmune hemolytic anemia can be roughly stratified into two groups according to serological features and secondary causes including drugs induced hemolytic anemia. Drugs induced autoimmune hemolytic anemia is very rare in pediatric patients. Read More

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November 2018
1 Read

Pharmacological Treatment of Major Depressive Episodes with Mixed Features: A Systematic Review.

Clin Psychopharmacol Neurosci 2018 Nov;16(4):376-382

Department of Psychiatry, Naju National Hospital, Naju, Korea.

We reviewed clinical studies investigating the pharmacological treatment of major depressive episodes (MDEs) with mixed features diagnosed according to the dimensional criteria (more than two or three [hypo]manic symptoms+principle depressive symptoms). We systematically reviewed published randomized controlled trials on the pharmacological treatment of MDEs with mixed features associated with mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). We searched the PubMed, Cochrane Library, and ClinicalTrials. Read More

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November 2018
5 Reads

Neuroleptic malignant syndrome and serotonin syndrome.

Handb Clin Neurol 2018 ;157:663-675

Department of Emergency Medicine, Division of Medical Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address:

The clinical manifestation of drug-induced abnormalities in thermoregulation occurs across a variety of drug mechanisms. The aim of this chapter is to review two of the most common drug-induced hyperthermic states, serotonin syndrome and neuroleptic malignant syndrome. Clinical features, pathophysiology, and treatment strategies will be discussed, in addition to differentiating between these two syndromes and differentiating them from other hyperthermic or febrile syndromes. Read More

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January 2018
5 Reads

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting paliperidone.

Expert Rev Clin Pharmacol 2018 Dec 4;11(12):1237-1253. Epub 2018 Dec 4.

e University of Kentucky Mental Health Research Center at Eastern State Hospital , Lexington , KY , USA.

Introduction: This is a combined analysis of therapeutic drug monitoring (TDM) studies of long-acting injectable paliperidone formulations: monthly (PP1M) and three-month (PP3M) injections. Areas covered: Fourteen PP1M articles and one PP3M article were identified. Using the paliperidone concentration/dose (C/D) ratio as a measure of clearance provided a weighted mean of 7. Read More

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December 2018
1 Read

Multiple spontaneous small bowel perforations due to clozapine-Case report.

Int J Surg Case Rep 2018 Nov 1;53:262-264. Epub 2018 Nov 1.

General Surgery Department of Centro Hospitalar do Oeste, Portugal.

Introduction: Spontaneous free perforation of the small bowel is unusual. There are many causes of spontaneous small bowel free perforation such as: immune-mediated or inflammatory, infections, drugs and biological agents, congenital, metabolic, vascular and neoplasm. A severe adverse effect of antipsychotic drugs is intestinal ischemia, which could lead to perforation. Read More

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November 2018
5 Reads

Psoas Abscess as a Differential Diagnosis of Neuroleptic Malignant Syndrome in a Schizoaffective Disorder Patient With Catatonic Symptoms.

Prim Care Companion CNS Disord 2018 Nov 1;20(6). Epub 2018 Nov 1.

Psychiatry Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

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November 2018
7 Reads

Effectiveness of serotonergic drugs in the management of problem behaviors in patients with neurodevelopmental disorders.

Psychiatr Danub 2018 Nov;30(Suppl 7):644-647

Istituto Serafico di Assisi, Viale Guglielmo Marconi n.6 06081, Assisi, Perugia, Italy,

Neurodevelopmental disorders often result in disabilities associated with auto- and / or hetero-aggressive behaviors, that can be defined as "problem behaviors" (Lacy 2007). Therapeutic interventions are mainly directed towards the use of neuroleptic drugs or benzodiazepines, to ensure a rapid and significant sedation in most of cases. These pharmacological devices exposes the patient to clinical risks and/or long-term management difficulties. Read More

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November 2018
1 Read

Neuroleptic malignant syndrome in a patient treated with clotiapine.

Psychiatr Danub 2018 Nov;30(Suppl 7):415-417

Mental Health Unit, Centre Hospitalier Universitaire et Psychiatrique de Mons-Borinage (CHUP-MB), 24 Chemin du Chêne aux Haies, 7000 Mons, Belgium.

Background: Neuroleptic malignant syndrome (NMS), which is linked to the use of antipsychotic medication, is a potentially lethal neurological emergency. The interest of our study is that NMS induced by the use of clotiapine has never previously been described.

Subjects And Methods: We present the case of a 61-year old man whose sleep disorders were treated with clotiapine 40 mg/day. Read More

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November 2018
5 Reads

Toxic Myopathy due to Antidopaminergic Medication Without Neuroleptic Malignant Syndrome.

J Clin Neuromuscul Dis 2018 Dec;20(2):94-98

Departments of Pediatrics and.

Severe recurrent proximal muscle weakness without neuroleptic malignant syndrome secondary to antidopaminergic medication has rarely been reported. We report a 29-year-old man with history of obsessive compulsive disorder and Tourette syndrome who presented with 2 months of worsening dyspnea 3 weeks after starting ziprasidone 40 mg daily that required mechanical ventilation. A year before, after an increased risperidone dose from 0. Read More

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December 2018
6 Reads

Pharmacist-Initiated Management of a Suspected Case of Risperidone-Induced Neuroleptic Malignant Syndrome in an Aged-Care Resident. The Role of Residential Medication Management Reviews in Medication Safety.

J Pharm Pract 2018 Nov 14:897190018806414. Epub 2018 Nov 14.

1 Ward mm, Melbourne, Victoria, Australia.

A 70-year-old female aged-care resident was referred by her general practitioner for a residential medication management review after nurses reported difficulties with swallowing, episodes of hyperthermia, elevated blood pressure, and tachycardia. These symptoms were accompanied by increasing confusion and drowsiness. Risperidone had recently been prescribed to treat behavioral and psychological symptoms of dementia. Read More

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November 2018
3 Reads

Medicalization and Demedicalization - A Gravely Disabled Homeless Man with Psychiatric Illness.

N Engl J Med 2018 11;379(20):1885-1888

From the University of California, Los Angeles, Los Angeles (J.T.B.); and Brown University, Providence, RI (L.M.).

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November 2018

Solid Phase Extraction Purification of Saliva Samples for Antipsychotic Drug Quantitation.

Molecules 2018 Nov 12;23(11). Epub 2018 Nov 12.

Department of Analytical Chemistry, Medical University of Gdansk, Gen. J. Hallera 107, 80-416 Gdansk, Poland.

Saliva is far less popular as a diagnostic material than blood. This has resulted in a lack of procedures for the sampling and handling of saliva, e.g. Read More

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November 2018

Antidepressant Prescription Patterns in Bipolar Disorder: a Nationwide, Register-based Study in Korea.

J Korean Med Sci 2018 Nov 19;33(46):e290. Epub 2018 Oct 19.

Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Background: The role of antidepressants (ADs) in bipolar disorder is long-standing controversial issue in psychiatry. Many clinicians have used ADs as a treatment for bipolar depression, and the selection of therapeutic agents is very diverse and inconsistent. This study aimed to examine recent AD prescription patterns for patients with bipolar disorder in Korea, using the nationwide, population-based data. Read More

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November 2018
6 Reads

Pharmacologic prevention of postoperative delirium after on-pump cardiac surgery: A meta-analysis of randomized trials.

Medicine (Baltimore) 2018 Oct;97(43):e12771

Department of Substance-Related Disorders, Division of Psychiatry, Hefei No.4 People's Hospital, Anhui Mental Health Center.

Background: Postoperative delirium is a prevalent and disabling mental disorder in patients undergoing on-pump cardiac surgery. There is some evidence that the use of pharmacological interventions may reduce the risk of developing of postoperative delirium. Therefore, the aim of this meta-analysis was to determine the effect of pharmacologic agents for the prevention postoperative delirium after cardiac surgery. Read More

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October 2018
7 Reads

Extrapyramidal symptoms resulting from risperidone use in a four year old child: A case report.

J Pak Med Assoc 2018 Nov;68(11):1719-1720

Department of Pharmaceutical Services, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore, Pakistan.

Extrapyramidal symptoms (EPS) are the major constraint in the use of antipsychotic agents. It is usually forewarned whenever therapy with these agents is considered. In this case, we present a child diagnosed with relapsed Wilm's tumour, who developed EPS just after a short duration of initiation of risperidone prescribed as an appetite stimulant. Read More

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November 2018
7 Reads

Rate of and time to symptomatic remission in first-episode psychosis in Northern Malawi: A STROBE-compliant article.

Medicine (Baltimore) 2018 Nov;97(45):e13078

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.

Although longer duration of untreated psychosis (DUP) is associated with poor response to antipsychotic treatment, it remains unclear whether it independently influences time to symptomatic remission in first-episode psychosis (FEP). This study examined rate of symptomatic remission, and explored if DUP, premorbid functioning, global functioning, insight and socio-demographic characteristics were independently associated with time to symptomatic remission in FEP.This prospective study enrolled 126 FEP patients (aged 18-65) between June 2009 and September 2012. Read More

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November 2018
5 Reads

The combination of levomepromazine (methotrimeprazine) and rotigotine enables the safe and effective management of refractory nausea and vomiting in a patient with idiopathic Parkinson's disease.

Palliat Med 2018 Nov 8:269216318809569. Epub 2018 Nov 8.

1 City Hospitals Sunderland NHS Trust, Sunderland, UK.

Background:: This case report describes a patient with known idiopathic Parkinson's disease, being managed with transdermal rotigotine, whose refractory nausea and vomiting was successfully controlled with subcutaneous levomepromazine. No drug-induced extrapyramidal side effects emerged.

Case Presentation:: A patient was found to have a locally advanced serous carcinoma, causing secondary bowel obstruction. Read More

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November 2018
6 Reads

Associations between the -2548G/A Promoter and Baseline Weight and between Gln223Arg and Lys656Asn Variants and Change in BMI Scores in Arab Children and Adolescents Treated with Risperidone.

Mol Neuropsychiatry 2018 Oct 5;4(2):111-117. Epub 2018 Oct 5.

Departments of Psychiatry and Medical Genetics, University of Alberta, Edmonton, Alberta, Canada.

Data on baseline (antipsychotics-naïve) age, weight, and height, and change in these at 3 subsequent follow-up time points up to 313.6 days (95% CI 303.5-323. Read More

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October 2018
6 Reads

Consideration of Occult Infection and Sepsis Mimics in the Sick Patient Without an Apparent Infectious Source.

J Emerg Med 2018 Nov 2. Epub 2018 Nov 2.

Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas.

Background: Evaluation and treatment of the acutely ill patient is typically complicated by multiple comorbidities and incomplete medical histories. This is exemplified by patients with sepsis, whose care is complicated by variable presentations, shifting definitions, and a variety of potential sources. Many practitioners fail to consider and recognize less-common sources of infection in a timely manner. Read More

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November 2018
5 Reads

New tricks for an old dog: A repurposing approach of apomorphine.

Eur J Pharmacol 2018 Nov 2;843:66-79. Epub 2018 Nov 2.

Behavior and Basal Ganglia Research Unit (EA 4712), University of Rennes 1, Rennes, France; Institut des Neurosciences Cliniques de Rennes (INCR), Rennes, France; Movement Disorders Unit, Neurology Department, Pontchaillou University Hospital, Rennes, France.

Apomorphine is a 150-year old nonspecific dopaminergic agonist, currently indicated for treating motor fluctuations in Parkinson's disease. At the era of drug repurposing, its pleiotropic biological functions suggest other possible uses. To further explore new therapeutic and diagnostic applications, the available literature up to July 2018 was reviewed using the PubMed and Google Scholar databases. Read More

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November 2018
7 Reads

Quantitative comparison of drug efficacy in treating hot flashes in patients with breast cancer.

Breast Cancer Res Treat 2018 Nov 2. Epub 2018 Nov 2.

Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China.

Objective: This study aimed to quantitatively evaluate drug efficacy and identify relevant factors that affect the relief of hot flashes in patients with breast cancer.

Methods: A comprehensive literature search was performed using public databases. Randomized clinical studies on drug therapy for the treatment of hot flashes in patients with breast cancer were identified. Read More

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November 2018
2 Reads

Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.

Bioorg Med Chem Lett 2018 Oct 24. Epub 2018 Oct 24.

Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, United States. Electronic address:

Several recent reports have highlighted the feasibility of the use of penfluridol, a well-known antipsychotic agent, as a chemotherapeutic agent. In vivo experiments have confirmed the cytotoxic activity of penfluridol in triple-negative breast cancer model, lung cancer model, and further studies have been proposed to assess its anticancer activity and viability for the treatment of glioblastomas. However, penfluridol anticancer activity was observed at a dosage significantly higher than that administered in antipsychotic therapy, thus raising the concern for the potential onset of CNS side effects in patients undergoing intensive pharmacological treatment. Read More

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October 2018
3 Reads
2.420 Impact Factor

Influence of an inconsistent appearance of antipsychotics on drug adherence in patients with schizophrenia.

Medicine (Baltimore) 2018 Nov;97(44):e12990

Psychiatry Service, Bizkaia Mental Health Network, Portugalete, Bizkaia, Spain.

In this study, we aimed to determine whether an inconsistent appearance of antipsychotic drugs dispensed was associated with poorer adherence in patients with schizophrenia.To conduct this study, we linked information from different administrative healthcare databases from the Basque Country. Patients with a medication possession ratio (<80%) were considered to be nonadherent. Read More

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November 2018
1 Read

Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.

J Med Chem 2018 Nov 9;61(22):10017-10039. Epub 2018 Nov 9.

Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology , Huazhong University of Science and Technology , Wuhan 430074 , China.

Herein, a novel series of multireceptor ligands was developed as polypharmacological antipsychotic agents using the designed multiple ligand approach between dopamine receptors and serotonin receptors. Among them, compound 47 possessed unique pharmacological features, exhibiting high affinities for D, D, 5-HT, 5-HT, and 5-HT receptors and low efficacy at the off-target receptors (5-HT, histamine H, and adrenergic α receptor). Compound 47 showed dose-dependent inhibition of apomorphine- and MK-801-induced motor behavior, and the conditioned avoidance response with low cataleptic effect. Read More

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November 2018
2 Reads

Adverse reaction reports of neuroleptic malignant syndrome induced by atypical antipsychotic agents in the Japanese Adverse Drug Event Report (JADER) database.

Psychiatry Clin Neurosci 2018 Oct 29. Epub 2018 Oct 29.

Graduate School of Health Management, Keio University, Kanagawa, Japan.

Aim: This study evaluates reports on neuroleptic malignant syndrome (NMS) as an adverse event associated with the use of atypical antipsychotic agents (AAAs) in Japan. We examined NMS occurrence following monotherapy and combination therapy with AAAs in real clinical practice using the Japanese Adverse Drug Event Report database.

Methods: Adverse drug reaction reports associated with the use of one or more AAAs or haloperidol were analyzed. Read More

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October 2018
4 Reads

ADMA and NT pro-BNP are associated with overall mortality in elderly.

Eur J Clin Invest 2018 Oct 26:e13041. Epub 2018 Oct 26.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Background: Increased asymmetrical dimethylarginine (ADMA) and NT pro-BNP concentrations have been associated with mortality in patients with cardiovascular (CV) disease and the general population. The use of these prognostic markers in an older population is not established yet. The aim of the present study was to investigate the prognostic value of age, sex, BMI, co-medication and CV laboratory risk markers in geriatric care patients. Read More

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October 2018
5 Reads

Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases.

Sci Rep 2018 Oct 25;8(1):15753. Epub 2018 Oct 25.

State Key Laboratory of Chemical Oncogenomics, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, P. R. China.

Epidemiological observations have shown that schizophrenia patients after long-term drug treatment exhibited reduced tumor incidences. The potential anticancer effects of antipsychotic drugs are subsequently demonstrated. These drugs are of great interest as agents against untreatable brain metastases because of their ability to traverse the blood-brain barrier (BBB). Read More

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October 2018
1 Read
5.080 Impact Factor

A systematic review of the use of risperidone, paliperidone and aripiprazole as augmenting agents for obsessive-compulsive disorder.

Expert Opin Pharmacother 2018 Oct 26:1-7. Epub 2018 Oct 26.

b UNSW/Usyd Co-Chair for Research Collaboration for Early and Mid-Career Researchers , Sydney , NSW , Australia.

Introduction: Obsessive-compulsive disorder (OCD) is often viewed as a difficult to treat disorder. In some patients, antipsychotics are used to augment the action of serotonin reuptake inhibitors (SRIs), particularly when there is only a partial response to treatment. Areas covered: This comprehensive literature review aims to assess the effectiveness and tolerability of three commonly used atypical antipsychotic agents: risperidone, paliperidone and aripiprazole, as augmentation agents in the treatment of OCD. Read More

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October 2018
1 Read

Atypical Antipsychotic Drug Olanzapine Deregulates Hepatic Lipid Metabolism and Aortic Inflammation and Aggravates Atherosclerosis.

Cell Physiol Biochem 2018 24;50(4):1216-1229. Epub 2018 Oct 24.

Department of Physiology, School of Medicine, National Yang-Ming University, Taipei,

Background/aims: Olanzapine, an atypical antipsychotic drug, has therapeutic effects for schizophrenia. However, clinical reports indicate that patients taking atypical antipsychotic drugs are at high risk of metabolic syndrome with unclear mechanisms. We investigated the effect of olanzapine on atherosclerosis and the mechanisms in apolipoprotein E-null (apoE-/-) mice. Read More

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November 2018
6 Reads

Selective adsorption and removal of drug contaminants by using an extremely stable Cu(II)-based 3D metal-organic framework.

Chemosphere 2019 Jan 15;215:524-531. Epub 2018 Oct 15.

Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan 523808, PR China. Electronic address:

The adsorption capacity of three representative pharmaceutical drugs and personal care products (PPCPs) viz. diclofenac sodium (DCF), chlorpromazine hydrochloride (CLF) and amodiaquin dihydrochloride (ADQ), were preliminarily studied using a water-stable Cu(II)-based metal organic framework (MOF) [Cu(BTTA)]·2DMF (1) (HBTTA = 1,4-bis(triazol-1-yl)terephthalic acid). We also investigated the factors influencing the adsorption such as concentration, pH, contact time, temperature and dosages. Read More

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January 2019
5 Reads

Effectiveness of Antiemetic Regimens for Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Network Meta-Analysis.

Oncologist 2018 Oct 17. Epub 2018 Oct 17.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Background: It is important to control chemotherapy-induced nausea and vomiting (CINV) to maintain dose intensity and patients' quality of life. The National Comprehensive Cancer Network guidelines suggest combination therapy of antiemetic agents. The growing number of antiemetic regimens, and in particular the growing use of regimens containing antagonists to the Nk-1 receptor (NK1RAs) and the antipsychotic drug olanzapine (OLZ), call for the re-evaluation of the optimal regimen for CINV. Read More

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October 2018
4.870 Impact Factor

Treating depression with adjunctive antipsychotics.

Bipolar Disord 2018 Nov;20 Suppl 2:17-24

Sophisticated Mood Appraisal & Refinement of Treatment (SMART) Group.

Objectives: To evaluate the efficacy and safety of using adjunctive antipsychotics in patients with major depressive disorder.

Method: Studies published since the last Cochrane review conducted in 2010 were identified via a literature search of recognised databases, using the keywords "adjunct*", "augment*", "antipsychotic" and "depression", and systematically evaluated. A targeted review of relevant guidelines was undertaken. Read More

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November 2018

Long-acting injectable antipsychotics as maintenance treatments for bipolar disorder-A critical review of the evidence.

Bipolar Disord 2018 Nov;20 Suppl 2:25-36

Sophisticated Mood Appraisal & Refinement of Treatment (SMART) Group.

Objectives: The maintenance phase of bipolar disorder is arguably the most important. The aim of management during this time is to maintain wellness and prevent future episodes of illness. Medication is often the mainstay of treatment during this phase, but adherence to treatment is a significant problem. Read More

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November 2018