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    2520 results match your criteria Neuroleptic Malignant Syndrome

    1 OF 51

    Hypothermia due to Antipsychotic Medication: A Systematic Review.
    Front Psychiatry 2017 7;8:165. Epub 2017 Sep 7.
    Parnassia Psychiatric Institute, The Hague, Netherlands.
    Background: Hypothermia is a rare, but potentially fatal adverse effect of antipsychotic drug (APD) use. Although the opposite condition, hyperthermia, has been researched extensively in the context of the malignant antipsychotic syndrome, little is known about hypothermia due to APDs.

    Objective: This study aimed to review the literature on hypothermia in the context of APD use, and formulate implications for research and clinical care. Read More

    Drug information update. Atypical antipsychotics and neuroleptic malignant syndrome: nuances and pragmatics of the association.
    BJPsych Bull 2017 Aug;41(4):211-216
    Government Medical College and Hospital, Chandigarh, India.
    Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal adverse event associated with the use of antipsychotics. Although atypical antipsychotics were initially considered to carry no risk of NMS, reports have accumulated over time implicating them in NMS causation. Almost all atypical antipsychotics have been reported to be associated with NMS. Read More

    Acute Presentation of Nonmotor Symptoms in Parkinson's Disease.
    Int Rev Neurobiol 2017 10;134:973-986. Epub 2017 Jul 10.
    Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:
    There are a few syndromes involving the nonmotor symptoms of Parkinson's disease and other movement disorders that can quickly lead to severe morbidity and mortality, and, as such, need rapid identification and management. Among these are neuroleptic malignant syndrome, serotonin syndrome, dopamine agonist withdrawal syndrome, and dystonic storm. It is important to maintain a high index of suspicion for these disorders as lack of identification can lead to death. Read More

    [Treatment of hyperthermia].
    Ugeskr Laeger 2017 Jul;179(30)
    Hyperthermia is an uncontrolled elevation of body temperature exceeding the body's ability to dissipate heat. Hyperthermia can result in dangerously high core temperatures and can rapidly become fatal. Common causes include heat stroke, malignant hyperthermia, serotonin syndrome, neuroleptic syndrome, a few endocrine emergencies as well as numerous intoxications. Read More

    Movement side effects of antipsychotic drugs in adults with and without intellectual disability: UK population-based cohort study.
    BMJ Open 2017 Aug 3;7(8):e017406. Epub 2017 Aug 3.
    Division of Psychiatry, University College London, London, UK.
    Objectives: To measure the incidence of movement side effects of antipsychotic drugs in adults with intellectual disability and compare rates with adults without intellectual disability.

    Design: Cohort study using data from The Health Improvement Network.

    Setting: UK primary care. Read More

    Atypical Neuroleptic Malignant Syndrome: Diagnosis and Proposal for an Expanded Treatment Algorithm: A Case Report.
    A A Case Rep 2017 Aug 1. Epub 2017 Aug 1.
    From the *Department of Anesthesiology & Perioperative Medicine and †Division of Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
    Neuroleptic malignant syndrome (NMS) in the absence of an elevated creatine kinase is atypical and more difficult to diagnose. We present a patient with NMS significant risk factors who developed atypical NMS 6 days after a liver transplant. Symptoms of hyperthermia, altered mental status, dyskinesia, and autonomic instability (hypertension and tachycardia) coincided with promethazine administration, with rapid progression to fulminant NMS with lead pipe rigidity after a single injection of intramuscular ziprasidone. Read More

    [Prolonged neuroleptic malignant syndrome after Haloperidol injection].
    Med Klin Intensivmed Notfmed 2017 Jul 27. Epub 2017 Jul 27.
    Klinik für Innere Medizin I, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.
    Neuroleptic malignant syndrome (NMS) is a rare disorder caused by drug-induced dopamine-receptor-blockage or low dopamine concentration in the brain. It is a severe reaction to neuroleptic drugs in antipsychotic therapy. Symptoms in NMS typically consist of fever, muscle rigidity and cognitive changes; laboratory findings include elevated infectious disease markers and creatine kinase as well as signs of rhabdomyolysis. Read More

    Olanzapine induced neuroleptic malignant syndrome, treated with electroconvulsive therapy (ECT)-A case report.
    Asian J Psychiatr 2017 Jul 14. Epub 2017 Jul 14.
    NIMHANS, Bengaluru, India; Professor of Psychiatry and I/C Head of Psychiatric Rehabilitation Services, National Institute of Mental Health & Neurosciences (NIMHANS), Bengaluru 560029, India; NIMHANS, Bengaluru, India. Electronic address:

    Transient lesions of the splenium of the corpus callosum following rapid withdrawal of levetiracetam.
    Epileptic Disord 2017 Jul 19. Epub 2017 Jul 19.
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido.
    Transient lesions of the splenium of the corpus callosum are characterized by MRI findings. The lesions are very rare, but significant from a clinical standpoint as differential diagnoses include serious conditions such as encephalitis, meningitis, and neuroleptic malignant syndrome. In addition, it is reported that some are attributed to the withdrawal of antiepileptic drugs. Read More

    Neuropsychiatric Manifestations of Scrub Typhus.
    J Neurosci Rural Pract 2017 Jul-Sep;8(3):421-426
    All India Institute of Medical Sciences, New Delhi, India.
    Scrub typhus is caused by Orientia tsutsugamushi characterized by focal or disseminated vasculitis and perivasculitis which may involve the lungs, heart, liver, spleen and central nervous system. It was thought to have been eradicated from India. Recently it is being reported from many areas of India. Read More

    Neuroleptic malignant syndrome in the trauma intensive care unit: Diagnosis and management of a rare disease in a challenging population.
    Int J Crit Illn Inj Sci 2017 Apr-Jun;7(2):119-121
    Department of Surgery, Division of Trauma, Critical Care, and Burn, The Ohio State University, OH, USA.
    Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder associated with the use of antipsychotic medications. Many of its classic signs, such as fever and altered mental status, are nonspecific in trauma intensive care unit (ICU) patients, and its rarity makes it a difficult diagnosis in this population. However, delays in treatment can be costly both in terms of hospital resources and patient outcomes. Read More

    Success of tardive electroconvulsive therapy sessions after loxapine-induced malignant syndrome in the context of very poor metabolisation.
    Therapie 2017 May 29. Epub 2017 May 29.
    Toxicology laboratory, department of medical pharmacology and toxicology, Lapeyronie hospital, CHRU of Montpellier, 34295 Montpellier cedex 5, France; University of Montpellier, 34000 Montpellier, France; UMR 5569 hydrosciences, 34090 Montpellier, France.
    We report the success of tardive electroconvulsive therapy in a case of loxapine malignant syndrome with catatonia. Loxapine and its metabolites were measured in biological samples by liquid chromatography coupled to tandem mass spectrometry. Genes were studied by sequencing and quantitative polymerase chain reaction (PCR). Read More

    Olanzapine-induced Neuroleptic Malignant Syndrome.
    Indian J Psychol Med 2017 May-Jun;39(3):364-365
    Department of Psychiatry, Institute of Psychiatry, Kolkata, West Bengal, India.
    Neuroleptic malignant syndrome (NMS) is a life-threatening adverse effect usually seen with typical antipsychotic drugs. Rarely, NMS can occur with atypical antipsychotics also. A 19-year-old male diagnosed as a case of acute and transient psychotic disorder developed NMS, following the treatment with an atypical antipsychotic, olanzapine 20 mg/day. Read More

    Common toxidromes in movement disorder neurology.
    Postgrad Med J 2017 Jun 7;93(1100):326-332. Epub 2016 Oct 7.
    Department of Neurology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.
    Background: Physicians can come across patients who are exposed to certain prescription drugs or toxins that can result in adverse effects and complications which have high rates of morbidity and mortality.

    Objective: To summarise the key clinical features and management of the common movement disorder toxidromes relevant to physicians (with an interest in neurology).

    Methods: We searched PUBMED from 1946 to 2016 for papers relating to movement toxidromes and their treatment. Read More

    Olanzapine-Induced Neuroleptic Malignant Syndrome.
    Iran J Med Sci 2017 May;42(3):306-309
    Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Department of Psychiatry, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Neuroleptic malignant syndrome (NMS) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. NMS mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. Although NMS is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drugs. Read More

    Leukodystrophy Presenting as Hyperactivity and Bipolarity with Uncommon Adverse Drug Reaction.
    Indian J Psychol Med 2017 Mar-Apr;39(2):202-204
    Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
    Leukodystrophy is a group of demyelinating neurodegenerative diseases of brain with varied presentation and multiple etiologies. Prognosis is predominantly dismal. Misdiagnosis and wrong treatment are common in this group of rare neurological disorders, especially when it presents with psychiatric symptoms. Read More

    Severe hyponatremia in a patient with schizophrenia associated with prolonged consciousness disturbance.
    CEN Case Rep 2017 May 18;6(1):5-11. Epub 2016 Oct 18.
    Department of Nephrology and Hypertension, Faculty of Blood Purification, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
    Hyponatremia presents with various central nervous system symptoms during its course and treatment. We treated a patient who presented with a prolonged consciousness disorder and was suspected of having complications of neuroleptic malignant syndrome and osmotic demyelination syndrome (ODS) during the treatment for his hyponatremia, which was caused by syndrome of inappropriate secretion of antidiuretic hormone (SIADH). The patient was a 30-year-old Japanese man who had been under treatment for schizophrenia. Read More

    The Role of Amantadine Withdrawal in 3 Cases of Treatment-Refractory Altered Mental Status.
    J Psychiatr Pract 2017 May;23(3):191-199
    FRYML, WILLIAMS, PELIC, FOX, SAHLEM, ROBERT, and SHORT: Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC REVUELTA: Department of Neurology and Neurosciences, Medical University of South Carolina, Charleston, SC.
    Amantadine, which was originally developed as an antiviral medication, functions as a dopamine agonist in the central nervous system and consequently is utilized in the treatment of Parkinson disease, drug-induced extrapyramidal reactions, and neuroleptic malignant syndrome. For reasons that are not entirely understood, abrupt changes in amantadine dosage can produce a severe withdrawal syndrome. Existing medical literature describes case reports of amantadine withdrawal leading to delirium, which at times has progressed to neuroleptic malignant syndrome. Read More

    Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription.
    SAGE Open Med Case Rep 2017 31;5:2050313X17695999. Epub 2017 Mar 31.
    Department of Psychological Medicine, King's College Hospital, South London and Maudsley NHS Foundation Trust, London, UK.
    Objectives: To describe a case of neuroleptic malignant syndrome following antipsychotic treatment of catatonia, highlighting the potentially serious complications of this rare adverse drug reaction.

    Methods: We present a case report of a patient who developed this syndrome with various sequelae.

    Results: The patient developed neuroleptic after being treated with lorazepam and olanzapine for catatonia. Read More

    Pharmacist intervention to detect drug adverse events on admission to the emergency department: Two case reports of neuroleptic malignant syndrome.
    J Clin Pharm Ther 2017 Aug 9;42(4):502-505. Epub 2017 May 9.
    Clinical Pharmacy Department, University Hospital, Montpellier, France.
    What Is Known And Objective: Neuroleptic malignant syndrome (NMS) is a rare but severe adverse effect of antipsychotic drugs.

    Case Description: We report two cases of NMS highlighted by clinical pharmacists in an emergency unit during summer. One of them was fatal. Read More

    Psychotic and Bipolar Disorders: Antipsychotic Drugs.
    FP Essent 2017 Apr;455:23-29
    Baylor Family Medicine Residency at Garland, 601 Clara Barton Blvd. Suite 340, Garland, TX 75042.
    Antipsychotic drugs block dopamine receptors and are used to manage psychosis as well as other mental illnesses that may or may not have psychotic features, such as bipolar disorders and major depressive disorder. First-generation antipsychotic drugs are more likely to cause adverse effects such as extrapyramidal symptoms and tardive dyskinesia. Adverse effects of second-generation antipsychotic drugs typically are related to metabolic abnormalities such as weight gain, abnormal blood glucose levels, and elevated lipid levels. Read More

    Response to benzodiazepines and the clinical course in malignant catatonia associated with schizophrenia: A case report.
    Medicine (Baltimore) 2017 Apr;96(16):e6566
    aDepartment of Neuropsychiatry bClinical Training Center, Kanazawa Medical University, Ishikawa, Japan.
    Background: Malignant catatonia (MC) is a disorder consisting of catatonic symptoms, hyperthermia, autonomic instability, and altered mental status. Neuroleptic malignant syndrome (NMS) caused by antipsychotics is considered a variant of MC. Benzodiazepine (BZD) medications are safe and effective treatments providing rapid relief from MC. Read More

    Neuroleptic Malignant Syndrome/Malignant Catatonia in Child Psychiatry: Literature Review and a Case Series.
    J Child Adolesc Psychopharmacol 2017 May 23;27(4):359-365. Epub 2017 Feb 23.
    4 Department of Psychiatry, University of Mississippi Medical Center , Jackson, Mississippi.
    Objective: To describe the presentation of neuroleptic malignant syndrome (NMS) and malignant catatonia (MC) in children and adolescents.

    Background: NMS and MC are life-threatening, neuropsychiatric syndromes, associated with considerable morbidity and mortality. NMS is diagnosed when there is a recent history of treatment with an antipsychotic (AP) medication, while MC is diagnosed when the symptoms resemble NMS but without a history of exposure to an AP agent. Read More

    Neuroleptic Malignant Syndrome Secondary to Metoclopramide Use in an Elderly Gastroenterologic Surgery Patient.
    Gastroenterol Nurs 2017 Mar/Apr;40(2):93-100
    Richard Breeden, PharmD, BCPS, BCNSP, is Assistant Professor, South College School of Pharmacy, Critical Care Pharmacist, Methodist Medical Center of Oak Ridge, Knoxville, Tennessee. Heath Ford, PharmD, PhD, CGP, is Assistant Professor, South College School of Pharmacy, Knoxville, Tennessee. Carey Chrisman, PharmD, is Affiliate Assistant Professor, University of Tennessee College of Pharmacy, and Critical Care Pharmacist, Methodist Medical Center of Oak Ridge, Oak Ridge, Tennessee. Charles Mascioli, MD, MBA, FCCP, is Critical Care Physician, Methodist Medical Center of Oak Ridge, Oak Ridge, Tennessee.
    An 84-year-old African American woman was admitted to the hospital secondary to severe abdominal pain accompanied by septic shock. She underwent exploratory laparotomy, which revealed extensive small bowel necrosis likely due to small bowel torsion. A small bowel resection was performed with primary anastomoses and the patient was subsequently transferred to the intensive care unit (ICU). Read More

    Progressive Encephalomyelitis with Rigidity and Myoclonus in an Intellectually Disabled Patient Mimicking Neuroleptic Malignant Syndrome.
    J Mov Disord 2017 May 24;10(2):99-101. Epub 2017 Mar 24.
    Department of Neurology, National Neuroscience Institute, Singapore, Singapore.
    We present a case of 32-year-old male with profound mental retardation and autism spectrum disorder who had presented with seizures, rigidity and elevated creatine kinase and was initially diagnosed as neuroleptic malignant syndrome (NMS). The patient subsequently had a complicated clinical course, developing refractory status epilepticus, which lead to the eventual diagnosis of progressive encephalomyelitis with rigidity and myoclonus (PERM). We discuss the clinical similarities and differences between NMS and PERM, and highlight the need to consider alternative diagnoses when the clinical picture of NMS is atypical, particularly in this patient group where the history and clinical examination may be challenging. Read More

    Atypical Neuroleptic Malignant Syndrome Associated with Use of Clozapine.
    Case Rep Emerg Med 2017 20;2017:2174379. Epub 2017 Feb 20.
    Emergency Department, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia.
    The Neuroleptic Malignant Syndrome (NMS) is a medical emergency of infrequent presentation in the emergency department, which is associated with the use of psychiatric drugs, such as typical and atypical antipsychotics. Our case addresses a 55-year-old patient diagnosed with undifferentiated schizophrenia for 10 years, who had been receiving clozapine and clonazepam as part of their treatment. This patient presents the symptoms of Neuroleptic Malignant Syndrome without fever, which improves with treatment especially with the withdrawal of clozapine. Read More

    A Retrospective Cohort Study of Acute Kidney Injury Risk Associated with Antipsychotics.
    CNS Drugs 2017 Apr;31(4):319-326
    Titus Family Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.
    Background: A recent large database analysis raised concerns of potential acute kidney injury (AKI) risk associated with antipsychotics. However, whether individual atypical and typical antipsychotics are associated with differential AKI risks has not been investigated.

    Objective: The current study compared the risks of AKI and known causes of AKI associated with a broad range of atypical and typical antipsychotics. Read More

    Malignant Catatonia Warrants Early Psychiatric-Critical Care Collaborative Management: Two Cases and Literature Review.
    Case Rep Crit Care 2017 30;2017:1951965. Epub 2017 Jan 30.
    Department of Medicine, Maricopa Medical Center, Phoenix, AZ, USA; College of Medicine, University of Arizona, Phoenix, AZ, USA; College of Medicine, Mayo Clinic, Scottsdale, AZ, USA.
    Malignant catatonia (MC) is a life-threatening manifestation which can occur in the setting of an underlying neuropsychiatric syndrome or general medical illness and shares clinical and pathophysiological features and medical comorbidities with the Neuroleptic Malignant Syndrome (NMS). The subsequent diagnosis and definitive therapy of MC are typically delayed, which increases morbidity and mortality. We present two cases of MC and review recent literature of MC and NMS, illustrating factors which delay diagnosis and management. Read More

    A systematic review of sex and age factors in neuroleptic malignant syndrome diagnosis frequency.
    Acta Psychiatr Scand 2017 May 1;135(5):398-408. Epub 2017 Feb 1.
    Veteran Affairs Boston Healthcare System, Boston MA and Harvard Medical School Department of Psychiatry, Boston, MA, USA.
    Objective: To examine sex and age distributions in neuroleptic malignant syndrome (NMS) patients based on a systematic literature review.

    Method: EMBASE and PubMed databases were searched to identify any observation of NMS published from January 1, 1998 through November 1, 2014 that was accessible and interpretable (using language translation software). Redundant and equivocal reports were excluded. Read More

    Neuroleptic malignant syndrome: an easily overlooked neurologic emergency.
    Neuropsychiatr Dis Treat 2017 16;13:161-175. Epub 2017 Jan 16.
    Department of Clinical Medicine, Section of Psychiatry, University of Bergen, Bergen, Norway.
    Neuroleptic malignant syndrome is an unpredictable iatrogenic neurologic emergency condition, mainly arising as an idiosyncratic reaction to antipsychotic agent use. It is characterized by distinctive clinical features including a change in mental status, generalized rigidity, hyperpyrexia, and dysautonomia. It can be lethal if not diagnosed and treated properly. Read More

    A Case of Olanzapine-Induced Fever.
    Psychopharmacol Bull 2017 Jan;47(1):45-47
    Drs. Yang, MD, Chen, MD, ScD, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan. Dr. Ying-Yeh Chen, MD, ScD, Institute of Public Health and Department of Public Health, National Yang-Ming University, Taipei, Taiwan.
    Olanzapine, a frequently used second-generation antipsychotic, has rarely been implicated as a cause of drug-induced fever in the absence of neuroleptic malignant syndrome. We describe a patient who developed isolated fever following olanzapine monotherapy, which subsided after discontinuation of olanzapine. Blockade of dopaminergic receptors and elevated cytokines concentration are possible mechanisms of fever development during treatment with olanzapine. Read More

    Neuroleptic Malignant Syndrome Associated with Valproate in an Adolescent.
    Clin Psychopharmacol Neurosci 2017 Feb;15(1):76-78
    Department of Child and Adolescent Psychiatry, Mersin University School of Medicine, Mersin, Turkey.
    Neuroleptic malignant syndrome (NMS) is a life-threatening idiosyncratic reaction that usually occurs after the administration of antipsychotic drugs. Antidepressants, benzodiazepines, and antiepileptic drugs are also suggested to be associated with NMS. It is believed to result from a dopaminergic blockade in the central nervous system. Read More

    Acute Dystonia Versus Neuroleptic Malignant Syndrome Without Fever in an Eight-Year-Old Child.
    Pediatr Emerg Care 2017 Jan;33(1):38-40
    From the *Department of Emergency Medicine, The Western Pennsylvania Hospital; and †Department of Emergency Medicine, Allegheny General Hospital, Pittsburgh, PA.
    Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication of the use of certain medications. It is being seen more often in the pediatric population because of the increasing use of both typical and atypical antipsychotics in children. Rapid recognition of NMS is important to emergency physicians because timely treatment can be life saving. Read More

    A Validation Study of the International Consensus Diagnostic Criteria for Neuroleptic Malignant Syndrome.
    J Clin Psychopharmacol 2017 Feb;37(1):67-71
    From the *VA Boston Healthcare System, Boston MA; †Department of Psychiatry, Harvard Medical School, ‡Boston Children's Hospital, Boston MA; §Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada; ∥Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA.
    Background: Neuroleptic malignant syndrome requires prompt recognition for effective management, but there are no established diagnostic criteria. This is the first validation study of recently published international expert consensus (IEC) diagnostic criteria, which include priority points assigned on the basis of the importance of each criterion for making a diagnosis of neuroleptic malignant syndrome.

    Methods: Data were extracted from 221 archived telephone contact reports of clinician-initiated calls to a national telephone consultation service from 1997 to 2009; each case was given a total priority point score on the basis of the IEC criteria. Read More

    Agitation Management in Pediatric Males with Anti-N-Methyl-D-Aspartate Receptor Encephalitis.
    J Child Adolesc Psychopharmacol 2016 Dec 22;26(10):939-943. Epub 2016 Sep 22.
    3 Department of Child and Adolescent Psychiatry, Ann & Robert H. Lurie Children's Hospital , Chicago, Illinois.
    Objectives: Severe agitation is a common symptom in pediatric cases of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis-an autoimmune encephalitis with prominent neuropsychiatric symptoms. Agitation is a major barrier to treatment of the underlying disease process and increases patients' risk of harming themselves and others. Furthermore, male patients often have undetectable tumors and are especially at risk for extended hospitalization, but have been infrequently studied. Read More

    Neurotoxicity and nephrotoxicity caused by combined use of lithium and risperidone: a case report and literature review.
    BMC Pharmacol Toxicol 2016 Dec 14;17(1):59. Epub 2016 Dec 14.
    Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Background: Combination lithium, a mood stabilizer, and risperidone, an atypical antipsychotic drug, is widely used for treatment of psychotic disorders. Rare reports concern severe adverse drug reaction in multiple organic systems with their combined use. We report two episodes of neurotoxicity and nephrotoxicity in a patient following the combined use of lithium and risperidone. Read More

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