2,623 results match your criteria Neuroleptic Malignant Syndrome


A Mixed Presentation of Serotonin Syndrome Versus Neuroleptic Malignant Syndrome in a 12-Year-Old Boy.

Pediatr Emerg Care 2019 Jan 4. Epub 2019 Jan 4.

Department of Public Health and Clinical Medicine Umeå University Umeå, Sweden Sunderby Research Unit Department of Clinical Sciences Division of Psychiatry Umeå University Umeå, Sweden.

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http://dx.doi.org/10.1097/PEC.0000000000001830DOI Listing
January 2019
1 Read

A rare iatrogenic association of syndrome of inappropriate secretion of antidiuretic hormone, neuroleptic malignant syndrome and rhabdomyolysis.

Oxf Med Case Reports 2019 Mar 29;2019(3):omz010. Epub 2019 Mar 29.

1U.O.C di Medicina Generale e Lungodegenza.

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is considered the prevalent cause of hyponatremia in hospitalized patients. Neuroleptic malign syndrome (NMS) is an idiosyncratic drug reaction showing fever, dysautonomia and rigidity with increased levels of Creatinine-phosphokinase (CPK) dependent on leakage of muscle contents into the circulation and defined as rhabdomyolysis. Although different diagnostic criteria for NMS have been established, it should be recognized that atypical presentations occur, particularly during treatment with atypical antipsychotics. Read More

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http://dx.doi.org/10.1093/omcr/omz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440259PMC
March 2019
2 Reads

An Approach to the Pharmacotherapy of Neuroleptic Malignant Syndrome.

Psychopharmacol Bull 2019 Feb;49(1):84-91

Van Rensburg, MBChB Dip HIV Man(SA), Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Decloedt, MBChB BSc(Hons) FCCP(SA) MMed(Clin Pharm), Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Neuroleptic malignant syndrome is a rare, idiosyncratic emergency associated with exposure to dopamine antagonists, commonly antipsychotic drugs. The typical clinical picture consists of altered consciousness, muscular rigidity, fever, and autonomic instability. While the condition has generally been well described, the pathophysiology is still poorly understood. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386430PMC
February 2019
1 Read

Neuroleptic malignant syndrome as part of an akinetic crisis associated with sepsis in a patient with Lewy body disease.

BMJ Case Rep 2019 Feb 28;12(2). Epub 2019 Feb 28.

Division of General Internal Medicine, School of Medicine, Tokai University, Isehara, Japan.

A 65-year-old Japanese woman with Parkinson's disease, later diagnosed with Lewy body disease, presented with a 2-day history of systemic tremors. She also had fever without rigidity or creatine kinase (CK) elevation. She was diagnosed with sepsis caused by pyelonephritis with acute kidney injury and parkinsonism exacerbation. Read More

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http://dx.doi.org/10.1136/bcr-2018-227216DOI Listing
February 2019
8 Reads

[Electroconvulsive therapy: 80 years of use in psychiatry].

Psychiatriki 2018 Oct-Dec;29(4):291-302

1st Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece.

Electroconvulsive therapy (ECT) is the oldest among the early biological treatments introduced in psychiatry, and the only one still in use. In this paper we attempt a brief presentation of ECT usage over the last 80 years, since it was originally introduced. It is a safe, well-tolerated, and highly effective treatment option for major psychiatric disorders, such as mood disorders and schizophrenia, especially when there is an acute exacerbation of psychotic symptoms or if catatonic symptoms are prominent. Read More

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http://dx.doi.org/10.22365/jpsych.2018.294.291DOI Listing
March 2019
4 Reads

Low Incidence of Neuroleptic Malignant Syndrome Associated With Paliperidone Palmitate Long-Acting Injectable: A Database Report and Case Study.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):180-182

The Zucker Hillside Hospital Glen Oaks, NY. and The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Glen Oaks, NY The Zucker Hillside Hospital Glen Oaks, NY. The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Glen Oaks, NY and Department of Child and Adolescent Psychiatry Charité Universitätsmedizin Berlin, Germany. Providence Care Hospital Kingston, Ontario, Canada. Janssen Research & Development LLC, Raritan, NJ.

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http://dx.doi.org/10.1097/JCP.0000000000001019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392211PMC
February 2019
1 Read

Clinically Significant Drug-Drug Interactions Involving Medications Used for Symptom Control in Patients With Advanced Malignant Disease: A Systematic Review.

J Pain Symptom Manage 2019 Feb 16. Epub 2019 Feb 16.

Regional Centre of Excellence for Palliative Care Western Norway, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine K1, University of Bergen, Bergen, Norway.

Context: Most patients with advanced malignant disease need to take several drugs to control symptoms. This treatment raises risks of serious adverse effects and drug-drug interactions (DDIs).

Objectives: To identify studies reporting clinically significant DDIs involving medications used for symptom control, other than opioids used for pain management, in adult patients with advanced malignant disease. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.006DOI Listing
February 2019
5 Reads

Emergent Treatment of Neuroleptic Malignant Syndrome Induced by Antipsychotic Monotherapy Using Dantrolene.

Clin Pract Cases Emerg Med 2019 Feb 4;3(1):16-23. Epub 2019 Jan 4.

Arrowhead Regional Medical Center, Department of Emergency Medicine, Colton, California.

Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication resulting from neuroleptic drug therapy. Presentation of NMS can vary, and diagnosis relies primarily upon medical history and symptomatology. Due to the potential delay in diagnosis, emergency physicians should remain vigilant in recognizing the symptoms of NMS and be prepared to initiate immediate treatment following diagnosis. Read More

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http://dx.doi.org/10.5811/cpcem.2018.11.39667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366389PMC
February 2019

The hot patient: acute drug-induced hyperthermia.

Aust Prescr 2019 Feb 1;42(1):24-28. Epub 2019 Feb 1.

Royal Prince Alfred Hospital, Sydney.

Drugs Can Cause Dysregulation Of The Hypothalamic–pituitary–adrenal Axis Which Can Result In A Rise In Core Temperature This Type Of Hyperthermia Is Unresponsive To Antipyretics And Can Be Complicated By Rhabdomyolysis Multi-organ Failure And Disseminated Intravascular Coagulation:

Organic Causes Of Fever Such As Infection Must Be Ruled Out Syndromes Associated With Drug-induced Fever Include Neuroleptic Malignant Syndrome And Anticholinergic Sympathomimetic And Serotonin Toxicity:

The Class Of Offending Drugs As Well As The Temporal Relationship To Starting Or Stopping Them Assists In Differentiating Between Neuroleptic Malignant Syndrome And Serotonin Toxicity:

Immediate Inpatient Management Is Needed The Mainstay Of Management Is Stopping The Drug And Supportive Care Often In The Intensive Care Unit: Read More

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https://www.nps.org.au/australian-prescriber/articles/the-ho
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http://dx.doi.org/10.18773/austprescr.2019.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370613PMC
February 2019
8 Reads

Movement Disorders Emergencies.

Semin Neurol 2019 Feb 11;39(1):125-136. Epub 2019 Feb 11.

Movement Disorders Division, Department of Neurology, Johns Hopkins, Baltimore, Maryland.

Many acute and potentially life-threatening medical conditions have hyperkinetic or hypokinetic movement disorders as their hallmark. Here we review the clinical phenomenology, and diagnostic principles of neuroleptic malignant syndrome, malignant catatonia, serotonin syndrome, Parkinsonism hyperpyrexia, acute parkinsonism, acute chorea-ballism, drug-induced dystonia, and status dystonicus. In the absence of definitive lab tests and imaging, only a high index of clinical suspicion, awareness of at-risk populations, and variations in clinical presentation can help with diagnosis. Read More

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http://dx.doi.org/10.1055/s-0038-1677050DOI Listing
February 2019
7 Reads

Aripiprazole Induced Late Neuroleptic Malignant Syndrome.

Am J Ther 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine, Saint Vincent Medical Center/Quinnipiac University Frank H. Netter School of Medicine, Bridgeport, CT.

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http://dx.doi.org/10.1097/MJT.0000000000000944DOI Listing
February 2019
15 Reads
1.127 Impact Factor

Management of Pulse Generators in a Breast Cancer Patient with in Situ Subthalamic Nucleus Deep Brain Stimulation.

J Neurol Surg A Cent Eur Neurosurg 2019 May 1;80(3):223-227. Epub 2019 Feb 1.

Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, the Republic of Korea.

Although deep brain stimulation (DBS) has been used for > 25 years in the treatment of movement disorders, no report has been published on the management of DBS pulse generators implanted in the anterior chest in patients with breast cancer who require mastectomy, radiotherapy, and future imaging studies.We describe a 62-year-old female patient with advanced Parkinson's disease (PD) who was dependent on bilateral subthalamic nucleus (STN) DBS. She was diagnosed with cancer in her left breast. Read More

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http://dx.doi.org/10.1055/s-0038-1677518DOI Listing
May 2019
3 Reads

Pulmonary embolism in a patient with neuroleptic malignant syndrome.

Authors:
Mosaad Almegren

Hematol Rep 2018 Nov 12;10(4):7753. Epub 2018 Dec 12.

Department of Medicine, Al Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.

Venous thromboembolism is one of the complications in patients prescribed antipsychotic medications. Neuroleptic malignant syndrome (NMS) is a rare side effect of antipsychotic medications in this population. In this case, a young patient, who presented with NMS after a recent start of antipsychotic medications, had developed a pulmonary embolism despite standard of care measures of venous thromboprophylaxis and early mobilization. Read More

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https://www.pagepress.org/journals/index.php/hr/article/view
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http://dx.doi.org/10.4081/hr.2018.7753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297863PMC
November 2018
21 Reads

Risperidone-Associated Neuroleptic Malignant Syndrome in an Inpatient With Schizophrenia, With Successful Rechallenge and 3 Year Follow-Up.

Front Psychiatry 2018 18;9:718. Epub 2018 Dec 18.

Department of Psychiatry, Show Chwan Memorial Hospital, Changhua, Taiwan.

Neuroleptic malignant syndrome (NMS) is rare but one of the most serious adverse effects of antipsychotics. Here, we report a case of risperidone-associated NMS in which a successful rechallenge of risperidone was observed with a positive follow-up. A 47-year-old female with schizophrenia was treated with risperidone 4 mg/d for 8 months in 2009 and was admitted to our hospital in 2015 owing to violent behavior under persecutory delusions. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305281PMC
December 2018
3 Reads

Neuroleptic malignant syndrome in a young adult female at the university of Benin Teaching Hospital: a case report.

Afr Health Sci 2018 Sep;18(3):786-789

Department of Anaesthesiology, University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria. Tel:+234 806-036-2070, +234 809-111-4193.

Background: Neuroleptic malignant syndrome is a rare but life-threatening idiosyncratic complication following the use of antipsychotic agents, anaesthesia and surgery. It is characterized by hyperthermia, muscle rigidity, autonomic disturbances and mental state alterations.

Case: A 31 year old female weighing 60kg received a depot preparation of Fluphenazine on account of depression with psychotic features observed two days prior to elective Cholecystectomy under general anaesthesia. Read More

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http://dx.doi.org/10.4314/ahs.v18i3.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306994PMC
September 2018
3 Reads

Parkinsonism-hyperpyrexia syndrome: A case report and review of literature.

Indian J Psychiatry 2018 Oct-Dec;60(4):499-503

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Parkinsonism-hyperpyrexia syndrome (PHS) is a rare but potentially life-threatening complication of the management of Parkinson's disease (PD). Central hypodopaminergic state which results due to abrupt withdrawal of dopaminergic medications in patients with PD is the postulated cause. Clinical manifestations of PHS are very akin to neuroleptic malignant syndrome (NMS). Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_113_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278220PMC
December 2018
4 Reads

Neuroleptic malignant-like syndrome causing thrombocytopaenia: a rare association.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Neuroleptic malignant-like syndrome is a rare but potentially fatal complication of sudden withdrawal of dopaminergic drugs. Clinical features are similar to that of neuroleptic malignant syndrome (NMS) like hyperthermia, autonomic dysfunction, altered sensorium, muscle rigidity; but instead of history of neuroleptic use, there is history of withdrawal of dopaminergic drugs. Laboratory examination generally show elevated creatine phosphokinase levels and may show elevated total leucocyte count. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-227089
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http://dx.doi.org/10.1136/bcr-2018-227089DOI Listing
December 2018
5 Reads

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Review of Psychiatric Phenotypes and Management Considerations: A Report of the American Neuropsychiatric Association Committee on Research.

J Neuropsychiatry Clin Neurosci 2018 Dec 18:appineuropsych18010005. Epub 2018 Dec 18.

From the Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston (Sarkis); the Menninger Clinic and Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (Coffey); the Department of Psychiatry, University of Illinois at Chicago (Cooper); the British Columbia Neuropsychiatry Program and Vancouver General Hospital Epilepsy Program, University of British Columbia (Hassan); and the Department of Psychiatry, University of Oxford, Oxford, United Kingdom (Lennox).

Objective:: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder characterized by prominent neuropsychiatric symptoms. Given the nature of its pathophysiology, psychiatrists tend to be one of the first clinicians encountering patients with the disease.

Methods:: In the present review of patients described in the literature with psychiatric symptoms, the authors aimed to characterize the psychiatric symptoms of the disease and its management in adults and adolescents as well as children (≤12 years old). Read More

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http://dx.doi.org/10.1176/appi.neuropsych.18010005DOI Listing
December 2018
2 Reads

Neuroleptic malignant syndrome: evaluation of drug safety data from the AMSP program during 1993-2015.

Eur Arch Psychiatry Clin Neurosci 2018 Nov 30. Epub 2018 Nov 30.

University Clinic for Psychiatry and Psychotherapy, Brandenburg Medical School, Immanuel Klinik Rüdersdorf, Seebad 82/83, 15562, Rüdersdorf bei Berlin, Germany.

Neuroleptic malignant syndrome (NMS) is a rare, but severe adverse drug reaction of drugs with anti-dopaminergic properties. The main symptoms are fever and rigor. In addition, other symptoms such as creatine kinase elevation, alteration of consciousness and various neurological symptoms may occur. Read More

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http://link.springer.com/10.1007/s00406-018-0959-2
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http://dx.doi.org/10.1007/s00406-018-0959-2DOI Listing
November 2018
12 Reads

Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.

Bosn J Basic Med Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Phenibut is a glutamic acid derivative with activity on the γ-aminobutyric acid (GABA) B and A, and β-phenethylamine receptors. It is prescribed in former Communist Bloc countries for anxiolysis and related psychiatric disorders. It can be easily obtained in Western countries, and is thought to have abuse potential. Read More

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http://www.bjbms.org/ojs/index.php/bjbms/article/view/4008
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http://dx.doi.org/10.17305/bjbms.2018.4008DOI Listing
December 2018
14 Reads

Neuroleptic malignant syndrome and serotonin syndrome.

Handb Clin Neurol 2018 ;157:663-675

Department of Emergency Medicine, Division of Medical Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address:

The clinical manifestation of drug-induced abnormalities in thermoregulation occurs across a variety of drug mechanisms. The aim of this chapter is to review two of the most common drug-induced hyperthermic states, serotonin syndrome and neuroleptic malignant syndrome. Clinical features, pathophysiology, and treatment strategies will be discussed, in addition to differentiating between these two syndromes and differentiating them from other hyperthermic or febrile syndromes. Read More

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00039-2DOI Listing
March 2019
18 Reads

Psoas Abscess as a Differential Diagnosis of Neuroleptic Malignant Syndrome in a Schizoaffective Disorder Patient With Catatonic Symptoms.

Prim Care Companion CNS Disord 2018 Nov 1;20(6). Epub 2018 Nov 1.

Psychiatry Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

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http://www.psychiatrist.com/PCC/article/Pages/2018/v20n06/18
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http://dx.doi.org/10.4088/PCC.18l02289DOI Listing
November 2018
19 Reads

Neuroleptic malignant syndrome in a patient treated with clotiapine.

Psychiatr Danub 2018 Nov;30(Suppl 7):415-417

Mental Health Unit, Centre Hospitalier Universitaire et Psychiatrique de Mons-Borinage (CHUP-MB), 24 Chemin du Chêne aux Haies, 7000 Mons, Belgium.

Background: Neuroleptic malignant syndrome (NMS), which is linked to the use of antipsychotic medication, is a potentially lethal neurological emergency. The interest of our study is that NMS induced by the use of clotiapine has never previously been described.

Subjects And Methods: We present the case of a 61-year old man whose sleep disorders were treated with clotiapine 40 mg/day. Read More

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November 2018
23 Reads

Toxic Myopathy due to Antidopaminergic Medication Without Neuroleptic Malignant Syndrome.

J Clin Neuromuscul Dis 2018 Dec;20(2):94-98

Departments of Pediatrics and.

Severe recurrent proximal muscle weakness without neuroleptic malignant syndrome secondary to antidopaminergic medication has rarely been reported. We report a 29-year-old man with history of obsessive compulsive disorder and Tourette syndrome who presented with 2 months of worsening dyspnea 3 weeks after starting ziprasidone 40 mg daily that required mechanical ventilation. A year before, after an increased risperidone dose from 0. Read More

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http://Insights.ovid.com/crossref?an=00131402-201812000-0000
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http://dx.doi.org/10.1097/CND.0000000000000233DOI Listing
December 2018
32 Reads

Pharmacist-Initiated Management of a Suspected Case of Risperidone-Induced Neuroleptic Malignant Syndrome in an Aged-Care Resident. The Role of Residential Medication Management Reviews in Medication Safety.

J Pharm Pract 2018 Nov 14:897190018806414. Epub 2018 Nov 14.

1 Ward mm, Melbourne, Victoria, Australia.

A 70-year-old female aged-care resident was referred by her general practitioner for a residential medication management review after nurses reported difficulties with swallowing, episodes of hyperthermia, elevated blood pressure, and tachycardia. These symptoms were accompanied by increasing confusion and drowsiness. Risperidone had recently been prescribed to treat behavioral and psychological symptoms of dementia. Read More

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http://dx.doi.org/10.1177/0897190018806414DOI Listing
November 2018
15 Reads

Consideration of Occult Infection and Sepsis Mimics in the Sick Patient Without an Apparent Infectious Source.

J Emerg Med 2019 Jan 2;56(1):36-45. Epub 2018 Nov 2.

Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas.

Background: Evaluation and treatment of the acutely ill patient is typically complicated by multiple comorbidities and incomplete medical histories. This is exemplified by patients with sepsis, whose care is complicated by variable presentations, shifting definitions, and a variety of potential sources. Many practitioners fail to consider and recognize less-common sources of infection in a timely manner. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679183095
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http://dx.doi.org/10.1016/j.jemermed.2018.09.035DOI Listing
January 2019
8 Reads

New tricks for an old dog: A repurposing approach of apomorphine.

Eur J Pharmacol 2019 Jan 2;843:66-79. Epub 2018 Nov 2.

Behavior and Basal Ganglia Research Unit (EA 4712), University of Rennes 1, Rennes, France; Institut des Neurosciences Cliniques de Rennes (INCR), Rennes, France; Movement Disorders Unit, Neurology Department, Pontchaillou University Hospital, Rennes, France.

Apomorphine is a 150-year old nonspecific dopaminergic agonist, currently indicated for treating motor fluctuations in Parkinson's disease. At the era of drug repurposing, its pleiotropic biological functions suggest other possible uses. To further explore new therapeutic and diagnostic applications, the available literature up to July 2018 was reviewed using the PubMed and Google Scholar databases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183064
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http://dx.doi.org/10.1016/j.ejphar.2018.10.052DOI Listing
January 2019
15 Reads

Adverse reaction reports of neuroleptic malignant syndrome induced by atypical antipsychotic agents in the Japanese Adverse Drug Event Report (JADER) database.

Psychiatry Clin Neurosci 2019 Jan 12;73(1):27-33. Epub 2018 Dec 12.

Graduate School of Health Management, Keio University, Kanagawa, Japan.

Aim: This study evaluates reports on neuroleptic malignant syndrome (NMS) as an adverse event associated with the use of atypical antipsychotic agents (AAA) in Japan. We examined NMS occurrence following monotherapy and combination therapy with AAA in real clinical practice using the Japanese Adverse Drug Event Report database.

Methods: Adverse drug reaction reports associated with the use of one or more AAA or haloperidol were analyzed. Read More

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http://dx.doi.org/10.1111/pcn.12793DOI Listing
January 2019
23 Reads

Acute Abdomen with Ileus: A Heralding Presentation of Neuroleptic Malignant Syndrome.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):566-569. Epub 2018 Sep 18.

Bronx Care Health System - Affiliate of Mount Sinai Hospital System, Bronx, New York, USA.

The pathophysiology of neuroleptic malignant syndrome (NMS) with use of psychotropic drugs is still unclear. Although a rare event with an incidence of 0.02-3. Read More

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https://www.karger.com/Article/FullText/492460
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http://dx.doi.org/10.1159/000492460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180277PMC
September 2018
17 Reads

Demystifying serotonin syndrome (or ).

Can Fam Physician 2018 Oct;64(10):720-727

Assistant Professor and Acting Director of the Doctor of Pharmacy program at the Leslie Dan Faculty of Pharmacy at the University of Toronto in Ontario, an advanced practice hospital pharmacist at the Centre for Addiction and Mental Health in Toronto, a doctoral candidate in the School of Health Professions Education at Maastricht University in the Netherlands, and a research fellow at the Wilson Centre in Toronto.

Objective: To review the symptoms of serotonin toxicity (commonly referred to as ) and the causative drugs and their mechanisms of action, and to equip primary care providers with practical strategies to prevent and identify serotonin toxicity.

Quality Of Evidence: PubMed and Google Scholar were searched for relevant articles on serotonin toxicity, the causes, and the differential diagnosis using search terms related to serotonin toxicity (), causes (individual names of drug classes, individual drug names), and diagnosis (). Experts in psychiatric medicine, psychiatric pharmacy, clinical pharmacology, and medical toxicology were consulted. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184959PMC
October 2018
8 Reads

Atypical Neuroleptic Malignant Syndrome Precipitated by Clozapine and Quetiapine Overdose: A Diagnostic Challenge.

Innov Clin Neurosci 2018 Jul-Aug;15(7-8):20-22. Epub 2018 Aug 1.

Drs. Teo, Wong and Tan are with the Department of Psychological Medicine, Changi General Hospital, Singapore.

Neuroleptic malignant syndrome (NMS) is a rare, idiosyncratic, but life-threatening adverse reaction associated with the use of antipsychotic drugs. It is characterized by a tetrad of fever, rigidity, autonomic instability, and altered mental status. Failure to diagnose NMS early and institute appropriate treatment can result in serious medical complications and death. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145603PMC
August 2018
22 Reads

Postmortem Hyperthermia: Two Case Reports and a Review of the Literature.

Am J Forensic Med Pathol 2018 Dec;39(4):364-366

Institut de médecine légale de Strasbourg, Université de Strasbourg, Strasbourg, France.

In this daily practice, the forensic pathologist is rarely confronted with postmortem hyperthermia associated with the rapid onset of rigor mortis. We report 2 similar cases where the rectal temperature value taken during the on-scene investigations by the forensic pathologist was greater than 40°C (104°F) in both cases, and rigor mortis was complete within less than 6 hours postmortem. The first case was due to a deadly intoxication by ecstasy and the second one to the deadly association of methadone and a possible neuroleptic malignant syndrome. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000431DOI Listing
December 2018
15 Reads

Management of common adverse effects of antipsychotic medications.

World Psychiatry 2018 Oct;17(3):341-356

Department of Psychiatry, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.

The benefits of antipsychotic medications are sometimes obscured by their adverse effects. These effects range from relatively minor tolerability issues (e.g. Read More

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http://dx.doi.org/10.1002/wps.20567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127750PMC
October 2018
4 Reads

[Antipsychotic-induced motor symptoms in schizophrenic psychoses-Part 2 : Catatonic symptoms and neuroleptic malignant syndrome].

Nervenarzt 2019 Jan;90(1):12-24

Zentrum für Psychosoziale Medizin, Klinik für Allgemeine Psychiatrie, Universität Heidelberg, Heidelberg, Deutschland.

In rare cases, pharmacotherapy in schizophrenic psychoses can be associated with life-threatening antipsychotic-induced movement disorders. The two most severe complications are antipsychotic-associated catatonic symptoms (ACS) and neuroleptic malignant syndrome (NMS). Although both constellations necessitate rapid medical care, the diagnosis is still a clinical challenge. Read More

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http://dx.doi.org/10.1007/s00115-018-0581-6DOI Listing
January 2019
9 Reads

A Case of Neuroleptic Malignant Syndrome in a Profoundly Intellectually Disabled Patient with Successful Reintroduction of Antipsychotic Therapy with Quetiapine.

Case Rep Psychiatry 2018 15;2018:7045106. Epub 2018 Jul 15.

Department of Psychiatry and Behavioral Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.

Neuroleptic Malignant Syndrome (NMS) is a rare condition clinically characterized by muscle rigidity, hyperthermia, autonomic instability, and acute mental status change. NMS is most often associated with use of high-potency first-generation antipsychotic medications; though, other neuroleptics have been implicated as well. NMS can be fatal with estimated mortality rates as high as 20%. Read More

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http://dx.doi.org/10.1155/2018/7045106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077586PMC
July 2018
6 Reads

Levosulpiride-induced neuroleptic malignant syndrome in rheumatoid arthritis.

BMJ Case Rep 2018 Aug 11;2018. Epub 2018 Aug 11.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

A 53-year-old woman, known case of diabetes mellitus and rheumatoid arthritis, presented with a 4-day history of hyperthermia, rigidity, tremor and altered sensorium. She developed these symptoms after having been administered parenteral levosulpiride to control vomiting due to secondary adrenal insufficiency. We managed her as a case of life-threatening neuroleptic malignant syndrome (NMS) requiring mechanical ventilation, bromocriptine and other supportive care. Read More

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http://dx.doi.org/10.1136/bcr-2018-224679DOI Listing
August 2018
5 Reads

Forced Diuresis and Expedient Blood Pressure Control in the Management of Quetiapine Induced Neuroleptic Malignant Syndrome: A Case Report.

Open Access Maced J Med Sci 2018 Jul 14;6(7):1267-1270. Epub 2018 Jun 14.

Karen Grech Rehabilition Hospital - Geriatrics, Pieta, Malta.

Background: This case report intends to highlight the importance of safeguarding renal function from rhabdomyolysis in neuroleptic malignant syndrome (NMS) by concomitant administration of parenteral fluids at a high rate together with high doses of parenteral loop diuretics (we utilised 6 mg bumetanide daily) and tailed over a few days, in order to preserve glomerular/renal medullary perfusion and nephron function.

Case Report: This case describes an elderly lady previously diagnosed with Lewy body dementia who had been started on low dose quetiapine a few days previously and presented with an acute 24 - 48 hour onset of fever, generalised stiffness, rapidly becoming uncommunicable and with high blood pressure. Haemoglobinuria was present prompting intravenous treatment with labetalol to address the BP, whereas rapid isotonic saline fluid infusions together with intravenous high dose bumetanide were instituted to safeguard the kidneys against damage due to nephron deposition, both from haemoglobinuria as well as possibly myoglobin from rhabdomyolysis. Read More

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http://dx.doi.org/10.3889/oamjms.2018.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062291PMC
July 2018
15 Reads

Neuroleptic Malignant Syndrome: The Value of Diagnostic Criteria.

Prim Care Companion CNS Disord 2018 Aug 2;20(4). Epub 2018 Aug 2.

Coventry and Warwickshire Partnership Trust, The Caludon Centre, Coventry, United Kingdom.

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http://dx.doi.org/10.4088/PCC.17l02218DOI Listing
August 2018
5 Reads

Neuroleptic malignant syndrome following reintroduction of an antipsychotic after overdose.

BMJ Case Rep 2018 Aug 3;2018. Epub 2018 Aug 3.

Department of Psychiatry, Assistance Publique Hopitaux de Marseille, Marseille, France.

Neuroleptic malignant syndrome (NMS) is a potentially lethal adverse drug reaction. We report a case of NMS potentially induced by dehydration in a female patient suffering from schizoaffective disorder. We discuss possible aetiologies and triggering factors alongside the existing literature. Read More

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http://dx.doi.org/10.1136/bcr-2017-223922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078231PMC
August 2018
4 Reads

Refining the psychiatric syndrome of anti-N-methyl-d-aspartate receptor encephalitis.

Acta Psychiatr Scand 2018 Nov 10;138(5):401-408. Epub 2018 Jul 10.

School of Medicine, University of Queensland, Brisbane, QLD, Australia.

Objective: To review the psychiatric symptoms of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, in an attempt to differentiate the presentation from a primary psychiatric disorder.

Method: A systematic literature review of PubMed and EMBASE of all published cases of anti-NMDA receptor encephalitis was performed from inception to January 2018.

Results: There were 706 cases of anti-NMDA receptor encephalitis identified. Read More

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http://dx.doi.org/10.1111/acps.12941DOI Listing
November 2018
18 Reads

Diagnostic, Treatment, and System Challenges in the Management of Recurrent Neuroleptic Malignant Syndrome on a General Medical Service.

Case Rep Psychiatry 2018 11;2018:4016087. Epub 2018 Jun 11.

Department of Psychiatry, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.

Neuroleptic malignant syndrome (NMS), an iatrogenic form of malignant catatonia, carries high morbidity and mortality rates especially in the context of delayed recognition and standard intervention protocol of lorazepam trial. However, there is limited guidance available through literature for further management if benzodiazepine treatment is ineffective and electroconvulsive therapy (ECT) is not readily accessible. This case report describes a multimodal approach to address the diagnostic, treatment, and logistical system challenges in an acute medical hospital through the case of a 69-year-old man with schizophrenia who represented from a psychiatric ward with neuroleptic malignant syndrome. Read More

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http://dx.doi.org/10.1155/2018/4016087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016165PMC
June 2018
5 Reads

Early detection of an atypical presentation of neuroleptic malignant syndrome: A case report.

Ment Health Clin 2017 May 23;7(3):137-142. Epub 2018 Mar 23.

Assistant Professor of Pharmacy Practice, Wingate University School of Pharmacy - Hendersonville Health Sciences Center, Hendersonville, North Carolina.

Neuroleptic malignant syndrome (NMS), which is considered a neurologic emergency, is believed to be caused by exposure to dopamine antagonist or withdrawal from a dopamine agonist. This article reports a case of suspected atypical NMS in a patient following rapid conversion of ziprasidone to risperidone without titration. While the initial presentation did not fully meet the , 5th edition, diagnostic features, a sequential treatment strategy was initiated and the patient appropriately responded to antipsychotic cessation in addition to combination therapy with dantrolene and bromocriptine. Read More

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http://dx.doi.org/10.9740/mhc.2017.05.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007570PMC
May 2017
6 Reads

Rituximab-Treated Pemphigus Foliaceus in a Schizophrenic Patient: A Challenging Exercise in Diagnosis, Management, and Follow-Up.

Skinmed 2018 1;16(2):129-131. Epub 2018 Apr 1.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA;

Dermatology was consulted in the care of a 58-year-old man with a history of paranoid schizophrenia, neuroleptic malignant syndrome, a positive purified protein derivative test, and a lack of bathing for approximately 4 years who had been admitted to the hospital because of thick, crusted lesions over an increasing portion of his body. Admitted involuntarily, he was disinterested in the history, physical examination, and diagnostic testing. Comorbid schizophrenia presented a unique challenge because he was unable to participate in his care effectively. Read More

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April 2018
7 Reads

Neurological melioidosis (Burkholderia pseudomallei) in a chronic psychotic patient treated with antipsychotics: A case report.

Medicine (Baltimore) 2018 06;97(24):e11110

Department of Neurology, Kaohsiung Armed Forces General Hospital, National Defense Medical Center, Taipei, Taiwan ( R.O.C.).

Rationale: Neurological melioidosis, an extremely rare condition, is caused by the gram-negative bacterium Burkholderia pseudomallei. If treatment is suboptimal or delayed, this infection can produce diverse clinical symptoms and result in death.

Patient Concerns: A healthy 65-year-old female who had been treated with antipsychotic medication for neurotic depression for over 2 years presented with acute-onset fever, headache, lead-pipe rigidity of all limbs, and delirium. Read More

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http://dx.doi.org/10.1097/MD.0000000000011110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023645PMC
June 2018
22 Reads

Olanzapine as a cause of neuroleptic malignant syndrome, bibliographic review following a clinical case.

Actas Esp Psiquiatr 2018 05 1;46(3):112-6. Epub 2018 May 1.

Department of Integrated Care. Health center area 8. Albacete.

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May 2018
6 Reads

Effects of dexmedetomidine on delirium duration of non-intubated ICU patients (4D trial): study protocol for a randomized trial.

Trials 2018 Jun 4;19(1):307. Epub 2018 Jun 4.

Département de Médecine Périopératoire (MPO), Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, 63003, Clermont-Ferrand, France.

Background: Delirium during intensive care unit (ICU) stay is frequent and associated with significant morbidity, mortality and healthcare-related costs. International guidelines suggest its prevention. However, curative treatment remains unclearly established. Read More

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http://dx.doi.org/10.1186/s13063-018-2656-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987410PMC
June 2018
23 Reads

Electroconvulsive therapy - general considerations and experience in Croatia.

Psychiatr Danub 2018 Jun;30(Suppl 4):188-191

University Hospital Centre Zagreb, Department of Psychiatry, Kišpatićeva 12, 10 000 Zagreb, Croatia,

Despite controversy, ECT has been recognized as significantly effective for the treatment of mental disorders since 1938, when Cerletti and Bini introduced ECT in clinical psychiatric practice for treatment of schizophrenia. In the next period, indication for ECT switched more toward depression and catatonia. ECT was even banned from psychiatric training in 1960's, due to the anti-psychiatric movement, which were fortified by Oscar winning movie "One Flew over the Cuckoo's Nest". Read More

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June 2018
11 Reads

A Mixed Presentation of Serotonin Syndrome vs Neuroleptic Malignant Syndrome in a 12-Year-Old Boy.

Pediatr Emerg Care 2018 Apr 24. Epub 2018 Apr 24.

Department of Child and Adolescent Psychiatry, University of California San Diego, San Diego, CA.

Background: Neuroleptic malignant syndrome (NMS) and serotonin syndrome (SS) are serious medical conditions associated with commonly prescribed psychiatric medications. Although the mechanisms differ, they can be clinically difficult to distinguish. We report a case of a pediatric patient with complicated psychiatric history that developed features of both syndromes in the setting of polypharmacy. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001477DOI Listing
April 2018
8 Reads