2,687 results match your criteria Neuroleptic Malignant Syndrome


Neuroleptic Malignant Syndrome in a COVID-19 Patient.

Brain Behav Immun 2020 May 18. Epub 2020 May 18.

Adventist Health White Memorial, Los Angeles, California.

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http://dx.doi.org/10.1016/j.bbi.2020.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232071PMC

Neuroleptic malignant syndrome in patients with cancer: a systematic review.

BMJ Support Palliat Care 2020 May 15. Epub 2020 May 15.

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan

Background: Antipsychotics potentially cause a low incidence of the side effect called neuroleptic malignant syndrome (NMS), which has a high mortality rate. However, few studies on NMS among patients with cancer exist.

Aims: We aimed to examine the characteristics of antipsychotic-induced NMS among patients with cancer. Read More

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http://dx.doi.org/10.1136/bmjspcare-2020-002200DOI Listing

Severe Agitation in a Teenager With Spastic Cerebral Palsy: A Clinical Challenge.

Pediatr Emerg Care 2020 May 6. Epub 2020 May 6.

Division of Pediatric Emergency Medicine, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA.

Neuroleptic malignant syndrome is a challenging diagnosis because it mimics many other conditions. We present a case of a 16-year-old boy with spastic cerebral palsy who presented with severe agitation, hyperthermia, and autonomic dysfunction. He arrived to a community pediatric hospital without a caregiver to provide a detailed history, which further complicated his management. Read More

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http://dx.doi.org/10.1097/PEC.0000000000002118DOI Listing

Hypermetabolic Syndrome and Dyskinesia After Neurologic Surgery for Labrune Syndrome: A Case Report.

A A Pract 2020 May;14(7):e01212

From the Department of Anesthesiology and Pain Medicine, Seattle Children's, Seattle, Washington.

A 20-year-old man with a rare neurodegenerative disease developed hypermetabolic symptoms with dyskinesia after a third ventriculostomy for hydrocephalus. The initial presentation was concerning for an acute dystonic reaction after metoclopramide was administered for nausea. He concurrently developed hypermetabolic symptoms, including hyperthermia, tachycardia, and a lactic acidosis. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001212DOI Listing

Lithium induced reversible Splenial lesion in neuroleptic malignant syndrome like symptoms: two case reports.

BMC Neurol 2020 Apr 30;20(1):164. Epub 2020 Apr 30.

Department of Neurology, Research Institute of Clinical Medicine of Jeonbuk National University - Biomedical Research Institute of Jeonbuk National University Hospital, Deokjin-gu, Jeonju-si, Jeonbuk-do, 54907, South Korea.

Background: Lithium is primarily used to treat bipolar disorder and is known to cause several acute neurological complications. Reversible splenial lesions (RSLs) may be evident in antiepileptic drug toxicity or withdrawal, infections, and other phenomena. We report two cases of RSL presenting as neuroleptic malignant syndrome-like symptoms (NMSLS) with lithium associated neurotoxicity. Read More

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http://dx.doi.org/10.1186/s12883-020-01742-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193363PMC

Risk of Neuroleptic Malignant Syndrome with Vesicular Monoamine Transporter Inhibitors.

Authors:
Stanley N Caroff

Clin Psychopharmacol Neurosci 2020 May;18(2):322-326

Department of Psychiatry, Corporal Michael J. Crescenz VA Medical Center and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Objective: Vesicular monoamine transporter-2 (VMAT2) inhibitors have been proven to be effective for the treatment of tardive dyskinesia and their use is likely to increase. The evidence base of published clinical reports was reviewed to evaluate the possible risk of neuroleptic malignant syndrome (NMS) with these drugs.

Methods: Pubmed, Embase, Web of Science and PsycINFO databases were queried for all years using terms for "neuroleptic malignant syndrome", "hyperthermia" AND "vesicular monoamine transporter inhibitors", "reserpine", "tetrabenazine", "valbenazine" or "deutetrabenazine". Read More

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http://dx.doi.org/10.9758/cpn.2020.18.2.322DOI Listing

Lamotrigine, quetiapine and aripiprazole-induced neuroleptic malignant syndrome in a patient with renal failure caused by lithium: a case report.

BMC Psychiatry 2020 Apr 19;20(1):179. Epub 2020 Apr 19.

Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 9 Curie-Skłodowskiej Street, 85-094, Bydgoszcz, Poland.

Background: Neuroleptic malignant syndrome (NMS) may be induced by atypical antipsychotic drugs (AAPDs) such as aripiprazole, olanzapine, risperidone and quetiapine, either as a single treatment or in combination with other drugs. A case of NMS following the administration of lamotrigine, aripiprazole and quetiapine in a patient with bipolar disorder, and with renal failure caused by toxic lithium levels has not been reported.

Case Presentation: A 51-year-old female patient with a 27-year history of bipolar disorder, being treated with lithium, fluoxetine, olanzapine, gabapentine, perazine and biperiden, was admitted to the hospital due to depressed mood and delusions. Read More

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http://dx.doi.org/10.1186/s12888-020-02597-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168987PMC

There is more to this fever than meets the eye: A case of neuroleptic malignant-like syndrome (NMLS) secondary to withdrawal of procyclidine and L-dopa on a background of long-standing flupenthixol depot use.

Ir J Psychol Med 2020 Apr 8:1-4. Epub 2020 Apr 8.

Psychiatry Department, University College Hospital, Galway, Republic of Ireland.

This case report highlights the risk of development of Neuroleptic Malignant-Like Syndrome secondary to withdrawal of procyclidine with brief withdrawal of L-dopa and long-term typical antipsychotic depot. The patient responded to reintroduction of procyclidine, sedation and supportive treatment. The mechanism and management of NMS and NMLS is also reviewed. Read More

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http://dx.doi.org/10.1017/ipm.2020.14DOI Listing

Deep brain stimulation as a possible treatment of hyperthermia in patients with serotonin syndrome.

Med Hypotheses 2020 Jun 1;139:109704. Epub 2020 Apr 1.

Department of Neurosurgery, Klinikum Fulda, University Medicine Marburg, Campus Fulda, Pacelliallee 2, 36043 Hessen, Germany.

Maintaining a body temperature within a narrow range is vital for the survival of all mammals, including humans. With the help of optogenetics, a better understanding of the thermoregulatory organs and pathways is achieved. Optogenetic activation of the GABAergic neurons in the ventral part of the lateral preoptic nucleus (VLPO) leads to decrease in the body temperature. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109704DOI Listing

Neuroleptic malignant syndrome: A case report.

Authors:

Nursing 2020 04;50(4):38-39

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http://dx.doi.org/10.1097/01.NURSE.0000659224.56124.78DOI Listing

Neuroleptic malignant syndrome: A case report.

Nursing 2020 Apr;50(4):32-38

Lisa A. Ruth-Sahd is a professor at the York College of Pennsylvania in York, Pa., and Georgetown University in Washington, D.C. Darris Rodrigues is a nurse at St. Luke's University Health Network in Fountain Hill, Pa. Elizabeth Shreve is a nursing student at York College of Pennsylvania.

Electroconvulsive therapy (ECT) is an increasingly popular treatment for drug-resistant depression that may have utility for some patients with neuroleptic malignant syndrome (NMS) who are unresponsive to pharmacotherapy. Using a case study as an example, this article discusses the diagnosis of a patient with NMS, the use of ECT as a treatment for NMS, and the importance of nursing care for these patients. Read More

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http://dx.doi.org/10.1097/01.NURSE.0000657056.57969.11DOI Listing

Coexistence of guanidinoacetate methyltransferase (GAMT) deficiency and neuroleptic malignant syndrome without creatine kinase elevation.

Brain Dev 2020 May 12;42(5):418-420. Epub 2020 Mar 12.

Karadeniz Technical University School of Medicine, Department of Pediatric Neurology, Ankara, Turkey.

We describe the first child with guanidinoacetate methyltransferase (GAMT) deficiency who developed neuroleptic malignant syndrome (NMS) after the treatment of risperidone without elevated creatine kinase (CK) levels. The patient presented with lethargy, hyperthermia, generalized tremor and rigidity with normal serum CK levels. After cessation of risperidone and adding clonezepam to the supportive treatment, symptoms of NMS were ameliorated. Read More

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http://dx.doi.org/10.1016/j.braindev.2020.02.001DOI Listing

Effect of Delirium on Physical Function in Noncardiac Thoracic Surgery Patients.

Am J Crit Care 2020 03;29(2):e39-e43

Babar A. Khan is an associate professor, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, and IU Center for Aging Research, Regenstrief Institute, Indianapolis, Indiana.

Background: The effect of delirium on physical function in patients undergoing noncardiac thoracic surgery has not been well described and may differ from that in other surgical populations.

Objective: To determine the effects of delirium on muscle strength and functional independence. The primary end point was change in Medical Research Council sum score (MRC-SS) by delirium status. Read More

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http://dx.doi.org/10.4037/ajcc2020579DOI Listing

Neuroleptic malignant syndrome in an afebrile patient on second generation antipsychotics.

Asian J Psychiatr 2020 Apr 11;50:101938. Epub 2020 Feb 11.

Sengkang General Hospital, Singapore Health Services, Singapore; Geriatric Education and Research Institute, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ajp.2020.101938DOI Listing

A Look at Genetic Linkage between Clozapine-induced Agranulocytosis, Malignant Hyperthermia, Neuroleptic Malignant Syndrome, and Statin-induced Myopathy.

Innov Clin Neurosci 2019 Nov;16(11-12):28-31

Dr. Pothen and Dr. Kansal are with Ocean Medical Center, Hackensack Meridian Health in Brick, New Jersey.

Clozapine-induced agranulocytosis, malignant hyperthermia (MH), statin-induced myopathy, and neuroleptic malignant syndrome (NMS) are all serious drug reactions with significant overlap in terms of clinical symptomatology. The use of clozapine can lead to neutropenia, as well as the development of NMS; thus, it seemed logical to explore a possible common genetic background for the development of these two adverse effects. Furthermore, due to the overwhelming clinical resemblance between NMS, MH, and statin-induced myopathy, we decided specifically to search for a common genetic background in the development of these conditions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006864PMC
November 2019

Catatonia revived: a unique syndrome updated.

Int Rev Psychiatry 2020 Feb 18:1-9. Epub 2020 Feb 18.

Department of Psychiatry, Penn State Medical School, Hershey, PA, USA.

Catatonia was buried within the confines of schizophrenia for over a century- deterring study, appropriate diagnosis and treatment for many years. With revised changes in the classification of this distinct neuropsychiatric syndrome, it is becoming more recognized clinically and in ongoing research. Catatonia occurs among various psychiatric, metabolic or neurologic conditions. Read More

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http://dx.doi.org/10.1080/09540261.2020.1723500DOI Listing
February 2020

Slow your role: How slowing clozapine titration can prevent recurrent NMS.

Schizophr Res 2020 Jan 20. Epub 2020 Jan 20.

Community Health Network, 6950 Hillsdale Court, Indianapolis, IN 46256, USA. Electronic address:

Ms. D. was a 57-year-old Caucasian female with a past psychiatric history of schizoaffective disorder bipolar type and unspecified anxiety disorder. Read More

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http://dx.doi.org/10.1016/j.schres.2019.11.028DOI Listing
January 2020

Serotonin Syndrome in the Emergency Department.

Cureus 2019 Dec 6;11(12):e6307. Epub 2019 Dec 6.

Emergency Medicine, Envision Physician Services, Orlando, USA.

With the widespread use of serotonergic agents including many antidepressants, antiemetics, illicit drugs, and even some herbal supplements, serotonin syndrome is a condition seen more frequently. It can appear abruptly and, if untreated, can progress to a life-threatening state. Prompt recognition and treatment is imperative to avoid complications. Read More

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http://dx.doi.org/10.7759/cureus.6307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944154PMC
December 2019

[Catatonia in clinical reality: underdiagnosed and forgotten].

MMW Fortschr Med 2019 12 11;161(Suppl 7):7-11. Epub 2019 Dec 11.

Klinik für Psychiatrie und Psychotherapie, Klinikum der Universität München (LMU), Nußbaumstraße 7, 80336, München, Deutschland.

Background: Catatonia is still a poorly understood, quite common, but often overlooked clinical picture. Consequences for patients are inadequate treatment, prolonged hospital stays and more serious complications.

Method: In this overview, the causes for an underdiagnosis are presented and measures for their prevention named, help for the differential diagnostic classification of catatonia is offered and the treatment is briefly explained. Read More

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http://dx.doi.org/10.1007/s15006-019-1173-5DOI Listing
December 2019

Treatment of the Neuroleptic Malignant Syndrome in International Therapy Guidelines: A Comparative Analysis.

Pharmacopsychiatry 2020 Mar 9;53(2):51-59. Epub 2019 Dec 9.

Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany.

Introduction: The neuroleptic malignant syndrome (NMS) is a potentially life-threatening condition associated to the use of antipsychotics. Since it requires rapid and efficient medical care, high-quality treatment guidelines should be available. In this article, we analyzed and compared different international therapy guidelines for the treatment of schizophrenia, in which NMS treatment recommendations might be contained. Read More

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http://dx.doi.org/10.1055/a-1046-1044DOI Listing

Editorial issue 4/2019.

Authors:
Siegfried Kasper

Int J Psychiatry Clin Pract 2019 11 6;23(4):237. Epub 2019 Dec 6.

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http://dx.doi.org/10.1080/13651501.2019.1688484DOI Listing
November 2019

Lifesaving Electroconvulsive Therapy for a Child With Autism Spectrum Disorder, Severe Self-Injurious Behavior, and Neuroleptic Malignant Syndrome.

J ECT 2019 Dec;35(4):e55-e56

Department of Pharmacy, Children's and Women's Health Centre of British Columbia.

We present a case of a preteen with autism spectrum disorder and severe self-injurious behavior who developed neuroleptic malignant syndrome on antipsychotics and required urgent electroconvulsive therapy and continued maintenance electroconvulsive therapy for ongoing clinical stability. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000598DOI Listing
December 2019

Electroconvulsive Therapy for Neuroleptic Malignant Syndrome: A Case Series.

J ECT 2019 Dec;35(4):225-230

From the Michigan Medicine Department of Psychiatry, The University of Michigan, Ann Arbor, MI.

Objectives: Neuroleptic malignant syndrome (NMS) is an uncommon condition associated with significant morbidity and mortality. Data on treatment interventions are limited. In this case series, we sought to describe all NMS cases requiring ECT from a large academic institution over a nearly 2-decade period. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000600DOI Listing
December 2019

The psychopharmacology of catatonia, neuroleptic malignant syndrome, akathisia, tardive dyskinesia, and dystonia.

Handb Clin Neurol 2019 ;165:415-428

Department of Psychiatry and Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands.

Although highly prevalent, motor syndromes in psychiatry and motor side effects of psychopharmacologic agents remain understudied. Catatonia is a syndrome with specific motor abnormalities that can be seen in the context of a variety of psychiatric and somatic conditions. The neuroleptic malignant syndrome is a lethal variant, induced by antipsychotic drugs. Read More

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http://dx.doi.org/10.1016/B978-0-444-64012-3.00025-3DOI Listing

The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review.

Br J Anaesth 2020 01 22;124(1):44-62. Epub 2019 Oct 22.

Department of Anaesthesia, Royal North Shore Hospital of Sydney, Sydney, NSW, Australia; Northern Clinical School, University of Sydney, Sydney, NSW, Australia.

Most cases of serotonin toxicity are provoked by therapeutic doses of a combination of two or more serotonergic drugs, defined as drugs affecting the serotonin neurotransmitter system. Common serotonergic drugs include many antidepressants, antipsychotics, and opioid analgesics, particularly fentanyl, tramadol, meperidine (pethidine), and methadone, but rarely morphine and other related phenanthrenes. Symptoms of serotonin toxicity are attributable to an effect on monoaminergic transmission caused by an increased synaptic concentration of serotonin. Read More

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http://dx.doi.org/10.1016/j.bja.2019.08.010DOI Listing
January 2020
1 Read

Drug-associated non-pyrogenic hyperthermia: a narrative review.

Eur J Clin Pharmacol 2020 Jan 23;76(1):9-16. Epub 2019 Oct 23.

Discipline of Pharmacy, College of Health and Medicine, University of Tasmania, Private Bag 26, Hobart, TAS, 7001, Australia.

Purpose: Hyperthermia occurs when heat accumulation surpasses the body's ability for heat dissipation. Many drugs may affect thermoregulation. This narrative review aimed to provide an overview of the current literature concerning reports of drug-associated non-pyrogenic hyperthermia. Read More

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http://link.springer.com/10.1007/s00228-019-02763-5
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http://dx.doi.org/10.1007/s00228-019-02763-5DOI Listing
January 2020
9 Reads

Risk of Neuroleptic Malignant Syndrome in Encephalitides: Response to Caroff.

Authors:
Rani A Sarkis

J Neuropsychiatry Clin Neurosci 2019 ;31(4):400

The Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1176/appi.neuropsych.18120392rDOI Listing
October 2019
1 Read

Phenomenology and Management of Encephalitis.

Authors:
Stanley N Caroff

J Neuropsychiatry Clin Neurosci 2019 ;31(4):399

The Department of Psychiatry, Corporal Michael J. Crescenz Veterans Affairs Medical Center and the Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1176/appi.neuropsych.18120392DOI Listing
October 2019
1 Read

Interfascicular Resection of Benign Peripheral Nerve Sheath Tumors.

JBJS Essent Surg Tech 2019 Jun 22;9(2):e18. Epub 2019 May 22.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Interfascicular resection is a surgical technique used to safely treat benign peripheral nerve sheath tumors through careful dissection of functional neural elements off the tumor surface.

Description: Proper operative technique is essential to improving symptoms, preserving neurologic function, and minimizing the chance for recurrence. Accurate tumor localization, ideal patient positioning, and placement of a longitudinal incision permit adequate exposure. Read More

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http://dx.doi.org/10.2106/JBJS.ST.18.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687493PMC
June 2019
1 Read

[Diagnostics and treatment of selected clinically relevant, acute drug intoxications].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Nov;62(11):1313-1323

Abteilung für Klinische Toxikologie & Giftnotruf München, Universitätsklinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland.

Acute drug poisoning due to accidental or self-damaging overdoses is responsible for 5-10% of emergency medical interventions in Germany. The treatment of asymptomatic to life-threatening courses requires extensive expertise. On the basis of a selective literature search, this article gives an overview of selected clinically relevant, acute drug poisonings with regard to epidemiology, symptomatology, diagnostics, and therapy. Read More

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http://dx.doi.org/10.1007/s00103-019-03024-7DOI Listing
November 2019
1 Read

Steroid-responsive Encephalopathy as a Semblance of Neuroleptic Malignant Syndrome in a Patient with Schizophrenia.

Indian J Psychol Med 2019 Sep-Oct;41(5):487-491. Epub 2019 Sep 5.

Department of Psychiatry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_307_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753705PMC
September 2019
5 Reads

Recognizing Movement Disorder Emergencies - A Practical Review For Non-Neurologist.

J Ayub Med Coll Abbottabad 2019 Jul-Sep;31(3):448-453

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.

Neurology still remains one of the most underserved specialties of medicine in Pakistan with roughly one neurologist per million people. Movement disorders (MD) are neurological problems that interfere with patient's motor abilities and diagnosis is typically clinical. In this review, we describe a practical approach to common MD emergencies that may be encountered by a non-neurologist physician, emphasizing on formulating a working diagnosis and their immediate management. Read More

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December 2019
4 Reads

Serotonin Syndrome: Pathophysiology, Clinical Features, Management, and Potential Future Directions.

Int J Tryptophan Res 2019 9;12:1178646919873925. Epub 2019 Sep 9.

Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

Serotonin syndrome (SS) (also referred to as serotonin toxicity) is a potentially life-threatening drug-induced toxidrome associated with increased serotonergic activity in both the peripheral (PNS) and central nervous systems (CNS). It is characterised by a dose-relevant spectrum of clinical findings related to the level of free serotonin (5-hydroxytryptamine [5-HT]), or 5-HT receptor activation (predominantly the 5-HT and 5-HT subtypes), which include neuromuscular abnormalities, autonomic hyperactivity, and mental state changes. Severe SS is only usually precipitated by the simultaneous initiation of 2 or more serotonergic drugs, but the syndrome can also occur after the initiation of a single serotonergic drug in a susceptible individual, the addition of a second or third agent to long-standing doses of a maintenance serotonergic drug, or after an overdose. Read More

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http://dx.doi.org/10.1177/1178646919873925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734608PMC
September 2019
3 Reads

[Malignant neuroleptic syndrome: An atypical case in an adolescent affected by bipolar I disorder associated with catatonic syndrome].

Encephale 2020 Apr 12;46(2):153-154. Epub 2019 Sep 12.

Service universitaire de psychiatrie de l'enfant et de l'adolescent, hôpitaux pédiatriques de Nice, CHU de LENVAL, 57, avenue de la Californie, 06200 Nice, France; Université Côte d'Azur, CoBTek, 06100 Nice, France.

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http://dx.doi.org/10.1016/j.encep.2019.08.001DOI Listing
April 2020
2 Reads

A Case Report: Atypical Neuroleptic Malignant Syndrome on Clozapine and Mood Stabilizers.

J Clin Psychopharmacol 2019 Sep/Oct;39(5):518-519

Department of Psychiatry Community Health Network and Marian University Indianapolis, IN Department of Psychiatry Community Health Network Indianapolis, IN.

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http://Insights.ovid.com/crossref?an=00004714-201909000-0002
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http://dx.doi.org/10.1097/JCP.0000000000001086DOI Listing
April 2020
20 Reads

Catatonia After Neuroleptic Malignant Syndrome Successfully Treated With Electroconvulsive Therapy.

Prim Care Companion CNS Disord 2019 Aug 15;21(4). Epub 2019 Aug 15.

985575 Nebraska Medical Center, Omaha, NE 68198-5575.

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http://dx.doi.org/10.4088/PCC.18l02376DOI Listing
August 2019
3 Reads

Takotsubo Cardiomyopathy: Medical and Psychiatric Aspects. Role of Psychotropic Medications in the Treatment of Adults with "Broken Heart" Syndrome.

Authors:
Valeriy Zvonarev

Cureus 2019 Jul 19;11(7):e5177. Epub 2019 Jul 19.

School of Behavioral Sciences, California Southern University, Costa Mesa, USA.

Takotsubo cardiomyopathy (TTC) is reversible stress-induced cardiomyopathy featuring symptoms of acute myocardial infarction without significant coronary artery abnormalities. TTC is frequently precipitated by stressful emotional events but it also has been reported as a result of substance withdrawal, non-cardiac events, and dangerous drug-to-drug interaction. The plasma levels of both epinephrine and norepinephrine were significantly elevated in TTC patients, suggesting that elevated catecholamine levels might be the main contributing factor. Read More

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http://dx.doi.org/10.7759/cureus.5177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695293PMC
July 2019
4 Reads

The Role of Physical Examinations in Psychiatry as Illustrated in a Case of Neuroleptic Malignant Syndrome Versus Viral Encephalitis: A Case Report and Literature Review.

Cureus 2019 Jun 5;11(6):e4840. Epub 2019 Jun 5.

Miscellaneous, American University of the Caribbean, Cupecoy, SXM.

Although a standard psychiatric evaluation includes a physical examination, there are no guidelines on the components of a comprehensive physical examination during psychiatric patient encounters. The mental status examination is frequently considered the psychiatric physical examination equivalent. We report a 59-year-old male inpatient on a medical unit who had hyperthermia, an altered mental status, muscle rigidity, and elevated white blood cell count and creatine phosphokinase level. Read More

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http://dx.doi.org/10.7759/cureus.4840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684120PMC
June 2019
4 Reads

Clinical determinants of fever in clozapine users and implications for treatment management: A narrative review.

Schizophr Res 2019 09 1;211:1-9. Epub 2019 Aug 1.

Mental Health Research Center at Eastern State Hospital, Lexington, KY and Psychiatry and Neurosciences Research Group (CTS-549), USA; Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.

Objectives: To identify the clinical determinants of fever in clozapine users and their impact on management of clozapine treatment.

Methods: Articles published in English or French identified with a MEDLINE, Web of Sciences, Cochrane Library and PsycINFO search, from inception through February 2019, using the term "clozapine" in combination with "fever" OR "hyperthermia" OR "body temperature" OR "pyrexia" OR "febrile" OR "heat" OR "thermoregulation". Information extracted for each medical condition were frequency, time to onset after initiation of clozapine treatment, characteristics of fever, associated symptoms, laboratory tests used for diagnosis, course, lethality, discontinuation of clozapine. Read More

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http://dx.doi.org/10.1016/j.schres.2019.07.040DOI Listing
September 2019
5 Reads

Rhabdomyolysis and Neuroleptic Malignant Syndrome Associated with Very Low-dose Antipsychotics in Children and Adolescent.

Clin Psychopharmacol Neurosci 2019 Aug;17(3):450-452

Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea.

Along with the field of adult psychiatry, antipsychotic agents are increasingly used in the field of child and adolescent psychiatry. Although neuroleptic malignant syndrome (NMS) and rhabdomyolysis are rare complication associated with antipsychotic agent, clinicians should need to pay attention to all potential adverse drug reaction (ADR). Also, ADRs in child and adolescent could show different signs and symptoms compared with those in adult. Read More

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http://dx.doi.org/10.9758/cpn.2019.17.3.450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705101PMC
August 2019
4 Reads

Alcohol Withdrawal Mimicking Neuroleptic Malignant Syndrome.

Cureus 2019 May 18;11(5):e4697. Epub 2019 May 18.

Internal Medicine, Windsor University School of Medicine, Boonton, USA.

Long-standing, heavy alcohol use can lead to alcohol dependence, which predisposes to alcohol withdrawal if alcohol consumption is suddenly decreased or stopped. Alcohol withdrawal syndrome is characterized by a hyperadrenergic response, with symptoms ranging from mild tremulousness to delirium tremens. We report a 55-year-old male presenting with hyperthermia, tachycardia, tachypnea, altered consciousness, tremors, rigidity, diaphoresis, elevated creatinine kinase, and myoglobinuria. Read More

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http://dx.doi.org/10.7759/cureus.4697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639086PMC
May 2019
5 Reads

Atypical neuroleptic malignant syndrome: A systematic review of case reports.

Gen Hosp Psychiatry 2019 Sep - Oct;60:12-19. Epub 2019 Jun 20.

Dept. of Psychiatry, All India Institute of Medical Sciences, Jodhpur 342005, Rajasthan, India.

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http://dx.doi.org/10.1016/j.genhosppsych.2019.06.009DOI Listing
April 2020
12 Reads

Effect of Pharmacist Intervention on a Population in Taiwan with High Healthcare Utilization and Excessive Polypharmacy.

Int J Environ Res Public Health 2019 06 21;16(12). Epub 2019 Jun 21.

Yong-xiang Pharmacy, Tainan City 70059, Taiwan.

Patients with high healthcare utilization are at increased risk of polypharmacy and drug interactions. This study investigated the changes in the number of medications, drug interactions and interaction severity in high frequency outpatients with polypharmacy at hospitals and clinics in Taiwan after home pharmaceutical care, to understand the effectiveness of interventions by pharmacists. This was a retrospective observational study. Read More

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http://dx.doi.org/10.3390/ijerph16122208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617324PMC
June 2019
5 Reads

Neuroleptic malignant syndrome: a concealed diagnosis with multitreatment approach.

BMJ Case Rep 2019 Jun 17;12(6). Epub 2019 Jun 17.

Department of Psychiatry and Mental Health, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal.

While neuroleptic malignant syndrome (NMS) is typically characterised by delirium, motor rigidity, fever and dysautonomia, the syndrome is not pathognomonic, and NMS remains a diagnosis of exclusion. Here, we describe the case of a 44-year-old woman, with no relevant psychiatric history, admitted to a nephrology unit due to acute renal failure. After administration of antipsychotics, she presented with mental status alteration, generalised tremor, rigidity and autonomic nervous system dysfunction. Read More

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http://dx.doi.org/10.1136/bcr-2018-225840DOI Listing
June 2019
23 Reads

Clozapine Rechallenge Following Neuroleptic Malignant Syndrome: A Systematic Review.

J Clin Psychopharmacol 2019 Jul/Aug;39(4):372-379

Department of Psychiatry, School of Medicine and Medical Sciences, University College.

Purpose/background: Neuroleptic malignant syndrome (NMS) has been described with most antipsychotics, most commonly first generation. Clozapine has also been associated with NMS.

Methods/procedures: We conducted a systematic review to identify all studies investigating or describing (a) clozapine rechallenge following suspected NMS associated with clozapine, (b) clozapine use after suspected NMS associated with another antipsychotic, and (c) rechallenge with nonclozapine antipsychotics after suspected clozapine-associated NMS. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001048DOI Listing
February 2020
14 Reads
3.243 Impact Factor

Characteristics of Patients Experiencing Extrapyramidal Symptoms or Other Movement Disorders Related to Dopamine Receptor Blocking Agent Therapy.

J Clin Psychopharmacol 2019 Jul/Aug;39(4):336-343

Department of Psychiatry, Community Health Network, Indianapolis, IN.

Purpose/background: Dopamine receptor blocking agents (DRBAs), also known as antipsychotics, are medications widely used to treat a growing number of mental health diagnoses. However, their utility is limited by the potential to cause serious adverse movement reactions. Akathisia, dystonia, parkinsonism, and tardive dyskinesia (collectively known as extrapyramidal symptoms or EPSs) are associated with reduced social and occupational functioning, negative patient attitudes toward treatment, and nonadherence to pharmacotherapy. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594730PMC
February 2020
20 Reads

Clinical utility of neutrophil-lymphocyte ratio in the diagnosis of neuroleptic malignant syndrome.

Nord J Psychiatry 2019 May - Jul;73(4-5):288-292. Epub 2019 Jun 5.

c Private Psychiatry Center , Istanbul , Turkey.

Neuroleptic malignant syndrome (NMS) is a life-threatening side effect of antipsychotic medication. In this study, we aimed to investigate the hypothesis of inflammation neutrophil-lymphocyte ratio (NLR) in the etiology of NMS. In this retrospective case-control study, data were collected using digital database of Bakırköy Mental Health Research and Training State Hospital by screening NMS diagnosis according to 'International Classification of Diseases (ICD-10) code: between the years of 2007 and 2017. Read More

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https://www.tandfonline.com/doi/full/10.1080/08039488.2019.1
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http://dx.doi.org/10.1080/08039488.2019.1623315DOI Listing
August 2019
7 Reads

Exertional Heatstroke in a Marathon Runner Complicated by Concurrent Use of an Antipsychotic Medication Affecting Thermoregulation.

Clin J Sport Med 2019 Jun 28. Epub 2019 Jun 28.

Sports Institute at UW Medicine and Department of Rehabilitation Medicine, University of Washington Medical Center, Seattle, Washington.

We report the case of a half-marathon runner who presented with exertional heatstroke (EHS), whose management was confounded by concurrent treatment of his bipolar disorder with olanzapine. Antipsychotics can have a profound effect on thermoregulation and can cause athletes to present with features of neuroleptic malignant syndrome in the setting of EHS. It is vital for medical providers to consider the thermoregulatory effects of all medications, including antipsychotics, when providing care during sporting events. Read More

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http://dx.doi.org/10.1097/JSM.0000000000000750DOI Listing
June 2019
9 Reads