2,837 results match your criteria Neuroleptic Malignant Syndrome


Risperidone-induced neuroleptic malignant syndrome: a case report.

Ther Adv Psychopharmacol 2022 14;12:20451253221094960. Epub 2022 May 14.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No 37 GuoXue Alley, Chengdu 610041, Sichuan, China.

Neuroleptic malignant syndrome (NMS) is a rare illness that results from reactions to antipsychotics. However, the diagnosis of NMS is challenging due to its atypical clinical presentation and unclear pathogenesis. We report the case of a patient with NMS induced by irregular use of antipsychotics, especially risperidone (RSP). Read More

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Facial and Abducens Nerve Palsies Following COVID-19 Vaccination: Report of Two Cases.

Neuroophthalmology 2022 15;46(3):203-206. Epub 2022 Feb 15.

Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

A broad spectrum of neurological side effects has been reported after immunisation for COVID-19, including functional neurological disorders, cerebral vascular events, cerebral venous thrombosis, intracerebral haemorrhage, neuroleptic malignant syndrome, cranial nerve palsies, and otologic manifestations. Multiple cranial neuropathies have also been reported following vaccination in which involvement of VII nerve is the most prevalent, followed by the VI, III, and IV nerves. We describe two male patients, one with with facial nerve palsy and the other with abducens nerve palsy following COVID-19 vaccination. Read More

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February 2022

Neuroleptic Malignant Syndrome with Adrenal Insufficiency After BNT162b2 COVID-19 Vaccination in a Man Taking Valproate: A Case Report.

Am J Case Rep 2022 May 6;23:e936217. Epub 2022 May 6.

Department of Nephrology, Tokyo Yamate Medical Center, Tokyo, Japan.

BACKGROUND Considering the ongoing coronavirus disease 2019 (COVID-19) pandemic, sufficient information about common and serious adverse events is needed to rapidly distribute COVID-19 vaccines worldwide. We report a case of neuroleptic malignant syndrome (NMS) with adrenal insufficiency after initial vaccination with Pfizer/BioNTech BNT162b2. CASE REPORT A 48-year-old man presented to the Emergency Department with fever and an altered mental status 7 days after receiving the first dose of the BNT162b2 COVID-19 vaccine. Read More

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Identifying rates and risk factors for medication errors during hospitalization in the Australian Parkinson's disease population: A 3-year, multi-center study.

PLoS One 2022 4;17(5):e0267969. Epub 2022 May 4.

SA Pharmacy, SA Health, Adelaide, South Australia, Australia.

Background: Admission to hospital introduces risks for people with Parkinson's disease in maintaining continuity of their highly individualized medication regimens, which increases their risk of medication errors. This is of particular concern as omitted medications and irregular dosing can cause an immediate increase in an individual's symptoms as well as other adverse outcomes such as swallowing difficulties, aspiration pneumonia, frozen gait and even potentially fatal neuroleptic malignant type syndrome.

Objective: To determine the occurrence and identify factors that contribute to Parkinson's medication errors in Australian hospitals. Read More

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A Case Report on Neuroleptic Malignant Syndrome (NMS): How to Approach an Early Diagnosis.

Cureus 2022 Mar 31;14(3):e23695. Epub 2022 Mar 31.

Psychiatry, Larkin Community Hospital, South Miami, USA.

Neuroleptic malignant syndrome (NMS) is a life-threatening neurological emergency that has been observed to occur in some patients following the administration of anti-dopaminergic agents or the rapid withdrawal of dopaminergic medications. In this report, the authors present a case of a 51-year-old male patient with a known history of cocaine abuse, who was given quetiapine during his hospitalization. This precipitated an episode of NMS that eventually concluded uneventfully due to quick diagnosis and management. Read More

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[Early recognition of antipsychotic malignant syndrome: prevention from worse in young people with dementia].

Ned Tijdschr Geneeskd 2022 03 10;166. Epub 2022 Mar 10.

De Wever, locatie De Hazelaar, Tilburg.

Antipsychotic malignant syndrome (AMS) sometimes is difficult to recognize. Four young persons with dementia developing AMS are presented. We emphasize that there may be signs to consider this diagnosis and how to distinguish between serotonergic syndrome and delirium. Read More

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Time to replace the term neuroleptic malignant syndrome with antidopaminergic syndrome?

Lancet Psychiatry 2022 05;9(5):348

Department of Neurology, Oslo University Hospital, Oslo, Norway; Institute of Clinical medicine, University of Oslo, Oslo, Norway.

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Case report: cold medicines cause neuroleptic malignant-like syndrome in a patient with Parkinson's disease.

Eur J Clin Pharmacol 2022 Apr 13. Epub 2022 Apr 13.

Department of Neurology, Institute of Geriatric Medicine, Beijing Hospital, National Center of Gerontology, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

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Case Report: A Patient With Neuroleptic Malignant Syndrome, Water Intoxication and Hyponatremia Associated With Severe Cerebral Edema and Coma.

Front Endocrinol (Lausanne) 2022 10;13:822679. Epub 2022 Mar 10.

Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan.

Background: Water intoxication is typically caused by primary or psychogenic polydipsia that potentially may lead to fatal disturbance in brain functions. Neuroleptic malignant syndrome (NMS) is a serious complication induced by administration of antipsychotics and other psychotropic drugs. The combination of inappropriate secretion of antidiuretic hormone (SIDAH), NMS and rhabdomyolysis have been rarely reported. Read More

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Severe Case of Oral Baclofen Withdrawal Resulting in Mechanical Ventilation.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211060584

UPMC Harrisburg Hospital, PA, USA.

Abrupt baclofen withdrawal may be life-threatening with varied neuropsychiatric manifestations. We present a case of baclofen withdrawal necessitating intubation. A 58-year-old female with a history of undiagnosed muscle spasticity presented with worsening extremities tremors, paresthesia, and weakness for 2 days. Read More

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Distinguishing between Neuroleptic Malignant Syndrome and Serotonin Syndrome in Polypharmacy: An Overview with a Case Report.

Psychiatr Danub 2021 ;33(Suppl 4):1227-1229

University Psychiatric Clinic Ljubljana, Chengdujska 45, 1260 Ljubljana Polje, Slovenia,

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Serotonin Syndrome Triggered by Overuse of Caffeine and Complicated With Neuroleptic Malignant Syndrome: A Case Report.

Cureus 2022 Feb 21;14(2):e22468. Epub 2022 Feb 21.

Community Medicine Management, Shimane University Faculty of Medicine, Izumo, JPN.

Serotonin syndrome is a rare complication occurring in patients with psychiatric disorders that are treated with selective serotonin reuptake inhibitors (SSRIs). There are various triggers for serotonin syndrome, including non-SSRI antidepressants. In rare cases, serotonin syndrome may be triggered by nonmedicinal foods, such as coffee. Read More

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February 2022

Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine".

Int J Mol Sci 2022 Mar 20;23(6). Epub 2022 Mar 20.

College of Medicine & Health Sciences, Khalifa University, Abu Dhabi 127788, United Arab Emirates.

Fine temperature control is essential in homeothermic animals. Both hyper- and hypothermia can have deleterious effects. Multiple, efficient and partly redundant mechanisms of adjusting the body temperature to the value set by the internal thermostat exist. Read More

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Catatonia in older adults: A systematic review.

World J Psychiatry 2022 Feb 19;12(2):348-367. Epub 2022 Feb 19.

Old Age Psychiatry Service, Cardinal Clinic, Windsor SL4 5UL, United Kingdom.

Background: Catatonia is a complex psychomotor syndrome that often goes unrecognized and untreated, even though its classification has evolved in recent years. Prompt and correct identification of catatonia allows for highly effective treatment and prevention of possible complications. The underrecognition of catatonia in older patients is also frequent, and research in this population is scarce. Read More

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February 2022

Exceptionally high creatine kinase levels in risperidone-induced neuroleptic malignant syndrome: A case report.

SAGE Open Med Case Rep 2022 15;10:2050313X221085096. Epub 2022 Mar 15.

Department of Chemical Pathology, National Hospital of Sri Lanka, Colombo.

Neuroleptic malignant syndrome is a rare, fatal antipsychotic-induced idiosyncratic reaction characterised by hyperthermia, altered consciousness, autonomic instability and rigidity with elevated creatine kinase levels and leukocytosis. Neuroleptic malignant syndrome and antipsychotics are significant causes for elevated creatine kinase among the extensive list of differential diagnoses. Risperidone is an atypical antipsychotic drug with anti-serotonergic and anti-dopaminergic properties which has a wide range of side effects, including neuroleptic malignant syndrome. Read More

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Neuroleptic malignant-like syndrome associated multiple system atrophy: report on three cases.

BMC Neurol 2022 Feb 25;22(1):67. Epub 2022 Feb 25.

Department of Geriatric Medicine and Shandong Key Laboratory of Cardiovascular Proteomics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 West Wenhua Road, Jinan, 250012, Shandong, China.

Background: Multiple system atrophy (MSA) associated with neuroleptic malignant-like syndrome (NMLS) is rare and few cases have been described in the literature.

Case Presentation: In the present study, three patients with MSA associated with NMLS were analyzed from January 2012 to January 2020 to characterize their clinical presentations. Data collected from the patients for analysis included general patient history, the fluctuation and severity of disease symptoms, the indicated therapies and disease progression at follow-up. Read More

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February 2022

Successful management of delirium with dexmedetomidine in a patient with haloperidol-induced neuroleptic malignant syndrome: A case report.

World J Clin Cases 2022 Jan;10(2):625-630

Department of Anesthesiology, National Taiwan University Hospital, Taipei 100220, Taiwan.

Background: We report a case of lorazepam-induced agitated delirium treated with haloperidol, which in turn triggered the onset of neuroleptic malignant syndrome (NMS). The latter condition, a medical emergency, was effectively treated with medical treatment and dexmedetomidine, a versatile and highly selective short-acting alpha-2 adrenergic agonist with sedative-hypnotic and anxiolytic effects.

Case Summary: A 65-year-old man with a history of bipolar disorder presented to the emergency department with severe abdominal discomfort after binge eating. Read More

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January 2022

[Electroconvulsive Therapy (ECT) in Neuroleptic Malignant Syndrome (NMS) on an Intensive Care Unit (ICU)].

Psychiatr Prax 2022 Jan 26. Epub 2022 Jan 26.

KMG Klinikum Güstrow GmbH, Klinik für Allgemeinpsychiatrie und Suchttherapie.

A 57-year-old female patient with unclear somnolence was admitted to an Intermediate Care Unit (IMC) by an emergency physician. Several psychotropic drugs were on the medication list (quetiapine 450 mg/d, paroxetine 40 mg/d and perphenazine 12 mg/d), due to depression with psychotic features. As the patient's state deteriorated on day 3, she was intubated and transferred to Intensive Care Unit (ICU), where a malignant hyperthermia (MH) was assumed. Read More

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January 2022

Beware of Neuroleptic Malignant Syndrome in COVID-19 Pandemic.

Innov Clin Neurosci 2021 Jul-Sep;18(7-9):9-10

Department of Emergency Medicine and Psychiatric Internal Medicine at Sunlight Brain Research Center in Yamaguchi, Japan.

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January 2022

Neuroleptic Malignant Syndrome due to Atypical Antipsychotics in a COVID-19-positive Pregnant Woman.

Indian J Crit Care Med 2021 Sep;25(9):1073-1074

Department of Anesthesia and Intensive Care, Sultan Qaboos University Hospital, Al Khod, Muscat, Oman.

Burad J, Kodange S. Neuroleptic Malignant Syndrome due to Atypical Antipsychotics in a COVID-19-positive Pregnant Woman. Indian J Crit Care Med 2021;25(9):1073-1074. Read More

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September 2021

Neuroleptic Malignant Syndrome in a Patient With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: Case Report and Review of Related Literature.

Neurohospitalist 2022 Jan 19;12(1):80-85. Epub 2021 Mar 19.

Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Introduction: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe but treatable disease that presents with symptoms similar to neuroleptic malignant syndrome (NMS).

Case Report: We describe a 28-year old female who initially presented with headaches, behavioral changes, anxiety, lip tremors, and rigidity of extremities. She was prescribed with olanzapine and later manifested with neuroleptic malignant syndrome symptoms such as decrease in sensorium, muscle rigidity, hyperthermia and tachycardia. Read More

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January 2022

Neuroleptic Malignant Syndrome in Children with Autism Spectrum Disorder (ASD): A Case Report and Brief Review of Recent Literature.

Children (Basel) 2021 Dec 18;8(12). Epub 2021 Dec 18.

IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, 56128 Pisa, Italy.

Neuroleptic malignant syndrome (NMS) is a rare, life-threatening, idiosyncratic adverse reaction to antipsychotic drugs. Despite the increasing rates in the prescription of antipsychotics in pediatric patients with autism spectrum disorder (ASD), little is known about the occurrence and hallmarks of NMS in this specific population. NMS appears to be part of the larger catatonia domain, based on the frequent relationship between ASD and catatonia, on the shared, when not overlapping, clinical features with malignant catatonia, and on the effectiveness of catatonia treatments on the NMS/MC symptoms. Read More

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December 2021

Neuroleptic malignant syndrome associated with COVID-19 vaccination.

CJEM 2022 04 17;24(3):349-350. Epub 2021 Dec 17.

Department of Emergency Medicine and Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu, Yamaguchi, 747-0066, Japan.

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Ropivacaine:An Unusual Cause of Neuroleptic Malignant-Like Syndrome.

Eur J Case Rep Intern Med 2021 8;8(11):002971. Epub 2021 Nov 8.

Serviço de Urgência Geral, Hospital de Braga, Braga, Portugal.

Ropivacaine is commonly used for post-operative pain management. We describe a case of neuroleptic malignant-like syndrome in a woman administered ropivacaine delivered using a drug infusion balloon. The presenting symptoms were confusion, agitation and fever. Read More

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November 2021

A case of influenza-associated invasive aspergillosis with cerebral hemorrhage due to infectious vasculopathy.

Radiol Case Rep 2022 Feb 26;17(2):326-331. Epub 2021 Nov 26.

Department of Medicine, Tokunoshima Tokushukai General Hospital, Kagoshima, Japan.

An invasive aspergillosis (IA) primarily occurs among immunocompromised patients. Recently with an influenzae infection prevalently spreading, influenzae-associated invasive aspergillosis (IAIA) has been reported occasionally. By contrast, neuroleptic malignant syndrome (NMS) occurs rarely in psychiatric patients who are treated with Olanzapine. Read More

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February 2022

Catatonia: Clinical Overview of the Diagnosis, Treatment, and Clinical Challenges.

Neurol Int 2021 Nov 8;13(4):570-586. Epub 2021 Nov 8.

Department of Anesthesiology, Louisiana State University Shreveport, Shreveport, LA 71103, USA.

Catatonia is a syndrome that has been associated with several mental illness disorders but that has also presented as a result of other medical conditions. Schizophrenia and other psychiatric disorders such as mania and depression are known to be associated with catatonia; however, several case reports have been published of certain medical conditions inducing catatonia, including hyponatremia, cerebral venous sinus thrombosis, and liver transplantation. Neuroleptic Malignant Syndrome and anti-NMDA receptor encephalitis are also prominent causes of catatonia. Read More

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November 2021

Paroxysmal hyperthermia, dysautonomia and rhabdomyolysis in a patient with Lesch-Nyhan syndrome.

JIMD Rep 2021 Nov 28;62(1):30-34. Epub 2021 Sep 28.

Department of Pediatrics, Division of Pediatric Neurology Boston University School of Medicine, Boston Medical Center Boston Massachusetts USA.

Lesch-Nyhan syndrome is an x-linked genetic disorder of purine metabolism that results in the overproduction of uric acid and neurologic deficits manifesting as intellectual disability, dystonia, other movement disorders and self-mutilation. We describe a 12-year-old patient with a history of Lesch-Nyhan syndrome, G6PD deficiency and central diabetes insipidus and multiple admissions for fever, acute kidney injury and transaminitis in the setting of rhabdomyolysis. The patient's temperature dysregulation and dysautonomia is likely attributable to abnormal neurotransmitter release, particularly that of dopamine, in the central nervous system. Read More

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November 2021

Neuroleptic malignant syndrome in children and adolescents: Systematic review of case reports.

Rev Colomb Psiquiatr (Engl Ed) 2021 Oct-Dec;50(4):290-300. Epub 2021 Nov 4.

Universidad de San Martín de Porres, Facultad de Medicina, Centro de Investigación en Salud Pública, Lima, Peru; Médico psiquiatra, Servicio de Psiquiatría General, Departamento de Psiquiatría, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru. Electronic address:

Introduction: Neuroleptic malignant syndrome (NMS) is a rare and potentially fatal drug adverse reaction. There are still few studies of this entity in the child-adolescent population.

Objectives: Describe the clinical, laboratory and therapeutic characteristics of children and adolescent patients with NMS. Read More

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November 2021

Antipsychotic Medication-Induced Hyperthermia Leading to Cerebrovascular Accident: A Case Report.

Cureus 2021 Oct 11;13(10):e18651. Epub 2021 Oct 11.

Internal Medicine, Howard University, Washington, DC, USA.

Antipsychotic medications are used in the management of schizophrenia. Antipsychotic medications treat both positive and negative symptoms via the dopamine D2 receptor and serotonin 5-HT2A blockade pathway. Side effects include hyperprolactinemia, prolonged QTc, and neuroleptic malignant syndrome. Read More

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October 2021

Probable haloperidol decanoate-induced fever in an African American with benign ethnic neutropenia: A case report.

Ment Health Clin 2021 Sep 24;11(5):301-304. Epub 2021 Sep 24.

Clinical Psychiatric Pharmacist, University of Maryland, Baltimore School of Pharmacy, Baltimore, Maryland; Springfield Hospital Center, Sykesville, Maryland.

We present a case in which a patient developed fever and leukocytosis subsequent to each monthly haloperidol decanoate injection, an adverse reaction that does not meet the diagnostic criteria of neuroleptic malignant syndrome (NMS) or any previously reported adverse reaction for this medication. A patient being treated with haloperidol decanoate for psychosis experienced a fever within 3 days of injection and leukocytosis along with swelling, pain, and a "knot" feeling at the injection site. This recurred after each injection for several months. Read More

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September 2021