2,958 results match your criteria Neuroimaging in Epilepsy Surgery


Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Clin Neurophysiol 2019 Jan 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.009DOI Listing
January 2019

Factors associated with early seizures after surgery of unruptured intracranial aneurysms.

Clin Neurol Neurosurg 2019 Mar 8;178:93-96. Epub 2019 Feb 8.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

Objective: The aim of the study was to better define the incidence of and risk factors for early seizures after repair of unruptured intracranial aneurysms in modern microsurgical techniques.

Patients And Methods: The medical records of 414 consecutive patients who underwent neck clipping of unruptured intracranial aneurysms in our institution over a 5-year period were retrospectively reviewed. Clinical and neuroimaging variables were analyzed to investigate putative predictors of perioperative seizures using multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.007DOI Listing

Comparing Single-Photon Emission Computed Tomography (SPECT), Electroencephalography (EEG), and Magneto-encephalography (MEG) Seizure Localizations in Pediatric Cases of Laser Ablation.

J Child Neurol 2019 Feb 12:883073818822353. Epub 2019 Feb 12.

3 University of Texas Dell Medical School, Austin, TX, USA.

Intractable epilepsy may have a more severe effect on children in comparison to adults because the motor, sensorial, and cognitive functions of children are still undergoing development. For this same reason, however, children maintain a greater potential for recovery from intractable epilepsy because of the remaining cerebral plasticity. Thus, after 2 unsuccessful antiepileptic medications, surgical intervention is recommended. Read More

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http://dx.doi.org/10.1177/0883073818822353DOI Listing
February 2019

Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke.

JAMA Neurol 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Kantonsspital St Gallen, St Gallen, Switzerland.

Importance: Predicting the duration of poststroke dysphagia is important to guide therapeutic decisions. Guidelines recommend nasogastric tube (NGT) feeding if swallowing impairment persists for 7 days or longer and percutaneous endoscopic gastrostomy (PEG) placement if dysphagia does not recover within 30 days, but, to our knowledge, a systematic prediction method does not exist.

Objective: To develop and validate a prognostic model predicting swallowing recovery and the need for enteral tube feeding. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.4858DOI Listing
February 2019
1 Read

Functional MRI and direct cortical stimulation: Prediction of postoperative language decline.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients.

Methods: In this prospective case series, 17 patients with drug-resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 with 1-year follow-up. All patients completed preoperative language fMRI, mapping with DCS of subdural electrodes, pre- and postoperative neuropsychological testing for language function, and resection. Read More

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http://doi.wiley.com/10.1111/epi.14666
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http://dx.doi.org/10.1111/epi.14666DOI Listing
February 2019
2 Reads

Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation.

Epilepsy Res 2019 Jan 29;151:17-23. Epub 2019 Jan 29.

Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.011DOI Listing
January 2019
1 Read

[Immediate outcomes of microsurgical treatment of cerebral arteriovenous malformations in non-hemorrhagic patients].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):30-37

Burdenko Neurosurgical Institute, Moscow, Russia.

Arteriovenous malformations (AVMs) are some of the most frequent congenital abnormalities of the cerebral vascular system and usually occur at a young age. Given the fact that AVMs can manifest, in addition to hemorrhages, as symptomatic epilepsy (17-40%) that occurs more often at a young age and may lead to significant disability, investigation of this pathology remains topical. Particular attention has recently been paid to the management of AVM patients without clinical signs of hemorrhage at the time of pathology diagnosis. Read More

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http://dx.doi.org/10.17116/neiro20188206130DOI Listing
January 2018

The neurological and psychological phenotype of adult patients with early-treated phenylketonuria: a systematic review.

J Inherit Metab Dis 2019 Jan 28. Epub 2019 Jan 28.

Division of Inborn Metabolic Diseases, Department of Paediatrics, University Hospital, Padua, Italy.

Newborn screening for phenylketonuria and early introduction of dietary therapy has been remarkably successful in preventing the severe neurological features of phenylketonuria, including mental retardation and epilepsy. However, concerns remain that long-term outcome is still suboptimal, particularly in adult patients who are no longer on strict phenylalanine-restricted diets. With our systematic literature review we aimed to describe the neurological phenotype of adults with early-treated phenylketonuria (ETPKU). Read More

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http://dx.doi.org/10.1002/jimd.12065DOI Listing
January 2019
2 Reads

Stereoelectroencephalography Versus Subdural Electrodes for Localization of the Epileptogenic Zone: What Is the Evidence?

Neurotherapeutics 2019 Jan;16(1):59-66

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, 15238, USA.

Accurate and safe localization of epileptic foci is the crux of surgical therapy for focal epilepsy. As an initial evaluation, patients with drug-resistant epilepsy often undergo evaluation by noninvasive methods to identify the epileptic focus (i.e. Read More

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http://dx.doi.org/10.1007/s13311-018-00703-2DOI Listing
January 2019

Changing temporal context in human temporal lobe promotes memory of distinct episodes.

Nat Commun 2019 01 14;10(1):203. Epub 2019 Jan 14.

Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal lobe as participants perform a verbal paired associates memory task that requires the encoding of distinct word pairs in memory. Read More

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http://dx.doi.org/10.1038/s41467-018-08189-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331638PMC
January 2019

Knowledge of language function and underlying neural networks gained from focal seizures and epilepsy surgery.

Brain Lang 2019 02 4;189:20-33. Epub 2019 Jan 4.

Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.

The effects of epilepsy and its treatments have contributed significantly to language models. The setting of epilepsy surgery, which allows for careful pre- and postsurgical evaluation of patients with cognitive testing and neuroimaging, has produced a wealth of language findings. Moreover, a new wave of surgical interventions, including stereotactic laser ablation and radio frequency ablation, have contributed new insights and corrections to language models as they can make extremely precise, focal lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093934X163009
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http://dx.doi.org/10.1016/j.bandl.2018.12.007DOI Listing
February 2019
7 Reads

Sudden unexpected death in epilepsy: The neuro-cardio-respiratory connection.

Seizure 2019 Jan 13;64:65-73. Epub 2018 Dec 13.

Athens University School of Medicine, Athens, Greece. Electronic address:

Sudden unexpected death in epilepsy (SUDEP) is the major cause of epilepsy-related premature mortality which targets preferentially younger people. Its etiology remains unknown. Several risk factors have been identified with generalized tonic-clonic seizures as the most important one; seizure control remains the most effective measure of prevention. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.12.007DOI Listing
January 2019
2 Reads

Mapping whole brain connectivity changes: The potential impact of different surgical resection approaches for temporal lobe epilepsy.

Cortex 2018 Nov 17;113:1-14. Epub 2018 Nov 17.

Neuroscience and Aphasia Research Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, UK. Electronic address:

In neurosurgery there are several situations that require transgression of the temporal cortex. For example, a subset of patients with temporal lobe epilepsy require surgical resection (most typically, en-bloc anterior temporal lobectomy). This procedure is the gold standard to alleviate seizures but is associated with chronic cognitive deficits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00109452183037
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http://dx.doi.org/10.1016/j.cortex.2018.11.003DOI Listing
November 2018
5 Reads

Imaging episodic memory during development and childhood epilepsy.

J Neurodev Disord 2018 Dec 13;10(1):40. Epub 2018 Dec 13.

Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Avenue NW, Washington, D.C., 20010, USA.

Epilepsy affects 2.2 million adults in the USA, with 1 in 26 people developing epilepsy at some point in their lives. Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy as medial structures, and the hippocampus in particular, are prone to generating seizures. Read More

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http://dx.doi.org/10.1186/s11689-018-9255-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292091PMC
December 2018

Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2019 Jan 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183074
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http://dx.doi.org/10.1016/j.yebeh.2018.10.033DOI Listing
January 2019
13 Reads
2.257 Impact Factor

Title.

Hong Kong Med J 2018 Nov 27. Epub 2018 Nov 27.

Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital, Yaumatei, Hong Kong.

Epilepsy is defined as drug-resistant after failure of two adequate trials of appropriately chosen and administered antiepileptic drugs. Approximately 30% of patients with epilepsy have drug-resistant epilepsy. Reasons for treatment failure include failure to recognise epilepsy syndrome, poor drug compliance, and lifestyle factors. Read More

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http://dx.doi.org/10.12809/hkmj187285DOI Listing
November 2018

Neurologic phenotypes associated with / mutations: Expanding the spectrum of disease.

Neurology 2018 Nov 9;91(22):e2078-e2088. Epub 2018 Nov 9.

From the Department of Clinical and Experimental Epilepsy (S.Z., Z.M., L.H.-H., S.K., S. Balestrini, S.M.S.) and Division of Neuropathology (Z.M., M.T.), UCL Institute of Neurology, London, UK; Clinic of Neurology (S.Z.), Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy; Department of Pediatric Neurology and Neurological Rehabilitation (C.S., T.H., P.W., G.J.K.) and Neurosurgery Clinic and Clinic for Epilepsy Surgery (M.K.), Schön Klinik Vogtareuth; Department of Pediatrics (C.S., M.S.), Children's Hospital Augsburg, Germany; UCL Great Ormond Street Institute of Child Health (J.R.N., K.V., S.M.V., J.H.C.), London, UK; Paediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G.), A. Meyer Children's Hospital, University of Florence, Italy; Chalfont Centre for Epilepsy (Z.M., L.H.-H., S.K., S. Balestrini, S.M.S.), Chalfont-St-Peter, Buckinghamshire, UK; CeGaT-Center for Genomics and Transcriptomics (A.P., S. Biskup), Tübingen, Germany; Neurogenetics Unit (M.L.), Department of Medical Genetics, Hospital de São João, Porto, Portugal; Department of Pediatrics and Adolescent Medicine (J.G.), University Medical Center Göttingen; Hospital for Children and Adolescents (A.M.), University Clinic Leipzig, Germany; Freiburg Medical Laboratory (M.J.), Dubai; The Danish Epilepsy Centre (R.S.M., E.G.), Dianalund; Institute for Regional Health Services (R.S.M., E.G.), University of Southern Denmark, Odense; Department of Clinical Genetics (B.S.K.), Odense University Hospital; Hans Christian Andersen Children's Hospital (L.K.H.), Odense, Denmark; Pediatric Neurology and Muscular Diseases Unit (M.S.V., P.S.), Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa "G. Gaslini" Institute, Italy; Division of Neurology (K.L.H.), Children's Hospital of Philadelphia, PA; Department of Neurology (S.D., C.L.S.-H.), Division of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD; Center for Genomic Medicine (N.H.-F.), Tohoku University; Department of Pediatrics (N.H.-F.), Tohoku University School of Medicine, Sendai, Japan; Department of Pediatrics (T.T., R.L.) and Institute of Clinical Medicine (K.O.), University of Tartu; Children's Clinic (T.T., R.L.), Department of Radiology (P.I.), and Department of Clinical Genetics, United Laboratories (K.O.), Tartu University Hospital, Estonia; Ludwig-Maximilians-University Munich (I.K.); Department of Pediatric Neurology (A.H.), Clinic Traunstein; Children's Hospital (M.K.), Dr. Horst Schmidt Klinik, Wiesbaden; Altona Children's Hospital (J.H.), Hamburg; Department of Pediatrics (C. Makowski), Technische Universität München, Germany; Department of Clinical Genetics (S.G.), Royal North Shore Hospital, St Leonards; John Hunter Children's Hospital (G.M.S.), New Lambton Heights, New South Wales, Australia; Department of Neurology (R.T.), University Hospital of Wales; Institute of Psychological Medicine and Clinical Neurosciences (R.H.T.), Cardiff University; Division of Neuroradiology (C. Micallef), National Hospital for Neurology and Neurosurgery, London; Department of Brain Repair & Rehabilitation (D.J.W.), Stroke Research Centre, UCL Institute of Neurology, London, UK; Paracelsus Medical University (G.J.K.), Salzburg, Austria; and IRCCS Stella Maris Foundation (R.G.), Pisa, Italy.

Objective: To characterize the neurologic phenotypes associated with mutations and to seek genotype-phenotype correlation.

Methods: We analyzed clinical, EEG, and neuroimaging data of 44 new and 55 previously reported patients with mutations.

Results: Childhood-onset focal seizures, frequently complicated by status epilepticus and resistance to antiepileptic drugs, was the most common phenotype. Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282239PMC
November 2018
13 Reads

Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future.

J Korean Med Sci 2018 Oct 4;33(44):e279. Epub 2018 Oct 4.

Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Magnetic resonance-guided focused ultrasound (MRgFUS) is a new emerging neurosurgical procedure applied in a wide range of clinical fields. It can generate high-intensity energy at the focal zone in deep body areas without requiring incision of soft tissues. Although the effectiveness of the focused ultrasound technique had not been recognized because of the skull being a main barrier in the transmission of acoustic energy, the development of hemispheric distribution of ultrasound transducer phased arrays has solved this issue and enabled the performance of true transcranial procedures. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200905PMC
October 2018
1 Read
1.253 Impact Factor

[Initial Experience of Stereotactic EEG Insertion with Anchor Bolt:Problem Extraction and Improvement of Insertion Accuracy].

No Shinkei Geka 2018 Oct;46(10):917-924

Department of Neurosurgery, Kyoto University Graduate School of Medicine.

In recent years, stereotactic electroencephalography(SEEG)has been focused on as a new invasive method for epileptic focus detection. Although the covering area of the brain surface is smaller than the invasive estimation with subdural electrodes, SEEG can evaluate foci that are deeply seated, noncontiguous leaves, and/or bilateral hemispheres. In addition, SEEG can capture consecutive changes in seizure activity in three dimensions. Read More

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http://dx.doi.org/10.11477/mf.1436203839DOI Listing
October 2018
13 Reads

Stimulation-induced ictal vocalisation of left frontal lobe origin.

Epileptic Disord 2018 Oct;20(5):418-422

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

Pure ictal non-speech vocalisation occurs in frontal and temporal lobe epilepsies. Electrical stimulation of supplementary motor areas is reported to evoke vocalisation in selected patients. Here, we report a patient with focal epilepsy of the left anterior insula who had isolated monotonous vocalisation elicited by electrical stimulation of the left superior frontal gyrus. Read More

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http://dx.doi.org/10.1684/epd.2018.0990DOI Listing
October 2018
11 Reads

A web-based diagnostic reference centre for the European Reference Network "EpiCare": recommendations of the eNeuropathology working group.

Epileptic Disord 2018 Oct;20(5):339-345

Neuropathologisches Institut, Universitätsklinikum Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.

Epilepsy surgery is a valuable treatment strategy for a selected group of patients with drug-resistant focal epilepsy. While reliable disease classification is essential for the optimal management of patients in general and crucial for the development of more personalized therapies in the future, arriving at a precise diagnosis often poses considerable difficulties due to the broad and variant-rich spectrum of epilepsy-associated brain lesions. Given the scarcity of European institutions diagnostically focusing on the histopathology of epilepsy surgery cases, the provision of subspecialty expertise as well as training opportunities remains logistically and financially challenging. Read More

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http://dx.doi.org/10.1684/epd.2018.1002DOI Listing
October 2018
9 Reads

BOLD mapping of human epileptic spikes recorded during simultaneous intracranial EEG-fMRI: The impact of automated spike classification.

Neuroimage 2019 01 10;184:981-992. Epub 2018 Oct 10.

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, United Kingdom; MRI Unit, Epilepsy Society, Chalfont St Peter, Buckinghamshire, United Kingdom. Electronic address:

Objectives: Simultaneous intracranial EEG and functional MRI (icEEG-fMRI) can be used to map the haemodynamic (BOLD) changes associated with the generation of IEDs. Unlike scalp EEG-fMRI, in most patients who undergo icEEG-fMRI, IEDs recorded intracranially are numerous and show variability in terms of field amplitude and morphology. Therefore, visual marking can be highly subjective and time consuming. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183193
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http://dx.doi.org/10.1016/j.neuroimage.2018.09.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264381PMC
January 2019
10 Reads

Automated EEG source imaging: A retrospective, blinded clinical validation study.

Clin Neurophysiol 2018 Nov 24;129(11):2403-2410. Epub 2018 Sep 24.

Department of Clinical Neurophysiology, Danish Epilepsy Centre, Visby Allé 5, 4293 Dianalund, Denmark; Department of Clinical Neurophysiology, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus, Denmark. Electronic address:

Objective: To evaluate the accuracy of automated EEG source imaging (ESI) in localizing epileptogenic zone.

Methods: Long-term EEG, recorded with the standard 25-electrode array of the IFCN, from 41 consecutive patients with focal epilepsy who underwent resective surgery, were analyzed blinded to the surgical outcome. The automated analysis comprised spike-detection, clustering and source imaging at the half-rising time and at the peak of each spike-cluster, using individual head-models with six tissue-layers and a distributed source model (sLORETA). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.09.015DOI Listing
November 2018
1 Read

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction.

Front Neurosci 2018 11;12:628. Epub 2018 Sep 11.

Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.

High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein released by glia and neurons upon inflammasome activation and activates receptor for advanced glycation end products (RAGE) and toll-like receptor (TLR) 4 on the target cells. HMGB1/TLR4 axis is a key initiator of neuroinflammation. In recent days, more attention has been paid to HMGB1 due to its contribution in traumatic brain injury (TBI), neuroinflammatory conditions, epileptogenesis, and cognitive impairments and has emerged as a novel target for those conditions. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2018.00628
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http://dx.doi.org/10.3389/fnins.2018.00628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142787PMC
September 2018
2 Reads

Distinctive epileptogenic networks for parietal operculum seizures.

Epilepsy Behav 2018 Sep 27. Epub 2018 Sep 27.

Epilepsy Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China. Electronic address:

Objective: The present study investigated the electroclinical features and epileptogenic networks of parietal operculum seizures (POS) by using stereoelectroencephalography (SEEG) intracerebral recordings.

Methods: Comprehensive presurgical evaluation data of seven patients with drug-resistant epilepsy with POS were analyzed retrospectively. Stereoelectroencephalography-recorded seizures were processed visually and quantitatively by using epileptogenicity mapping (EM), which has been proposed to ergonomically quantify the epileptogenicity of brain structures with a neuroimaging approach. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183025
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http://dx.doi.org/10.1016/j.yebeh.2018.08.031DOI Listing
September 2018
3 Reads

Application of Awake Surgery for Epilepsy in Clinical Practice.

Neurol Med Chir (Tokyo) 2018 Oct 21;58(10):442-452. Epub 2018 Sep 21.

Department of Neurosurgery, Nagoya University School of Medicine.

Epilepsy surgery aims to control epilepsy by resecting the epileptogenic region while preserving function. In some patients with epileptogenic foci in and around functionally eloquent areas, awake surgery is implemented. We analyzed the surgical outcomes of such patients and discuss the clinical application of awake surgery for epilepsy. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186762PMC
October 2018
6 Reads

Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy.

Neuroimage Clin 2018 15;20:742-752. Epub 2018 Sep 15.

IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Epilepsy Unit, Department of Radiology, Hospital Clínic, Barcelona, Spain.

Chronic exposure to seizures in patients with left hemisphere (LH) epileptic focus could favor higher activation in the contralateral hemisphere during language processing, but the cognitive effects of this remain unclear. This study assesses the relationship between asymmetry in hemispheric activation during language fMRI and performance in verbal and non-verbal tasks. Whereas prior studies primarily used fMRI paradigms that favor frontal lobe activation and less prominent activation of the medial or superior temporal lobes, we used a verbal comprehension paradigm previously demonstrated to activate reliably receptive language areas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183028
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http://dx.doi.org/10.1016/j.nicl.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154460PMC
January 2019
13 Reads

Pre-Surgical Planning: Multimodality Imaging to Optimize Outcomes in Pediatric Epilepsy Surgery.

Authors:
Timothy P Zinkus

Mo Med 2018 Jul-Aug;115(4):365-367

Timothy P. Zinkus, MD, is Assistant Professor, Pediatric Radiology, Children's Mercy, University of Missouri, Kansas City, Kansas City, Mo.

Neuroimaging is an important component of the pre-surgical planning for pediatric epilepsy. High-resolution structural magnetic resonance images are combined with advanced structural and functional imaging techniques to better define the surgical lesion and decrease morbidity postoperatively. The combination of neuroimaging, electroencephalography (EEG), and neuropsychiatric testing in a multidisciplinary epilepsy conference setting is essential for determining a plan for surgical management. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140251PMC
September 2018
1 Read

Multimodal localization and surgery for epileptic spasms of focal origin: a review.

Neurosurg Focus 2018 Sep;45(3):E4

1Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

Epileptic spasms (ES) are a common manifestation of intractable epilepsy in early life and can lead to devastating neurodevelopmental consequences. Epilepsy surgery for ES is challenging because of inherent difficulties in localizing the epileptogenic zone in affected infants and children. However, recent clinical series of resective neurosurgery for ES suggest that not only is surgery a viable option for appropriately selected patients, but postoperative seizure outcomes can be similar to those achieved in other types of focal epilepsy. Read More

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http://dx.doi.org/10.3171/2018.6.FOCUS18217DOI Listing
September 2018
2 Reads

Phase-amplitude coupling between interictal high-frequency activity and slow waves in epilepsy surgery.

Epilepsia 2018 Oct 26;59(10):1954-1965. Epub 2018 Aug 26.

Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan.

Objective: We hypothesized that the modulation index (MI), a summary measure of the strength of phase-amplitude coupling between high-frequency activity (>150 Hz) and the phase of slow waves (3-4 Hz), would serve as a useful interictal biomarker for epilepsy presurgical evaluation.

Methods: We investigated 123 patients who underwent focal cortical resection following extraoperative electrocorticography recording and had at least 1 year of postoperative follow-up. We examined whether consideration of MI would improve the prediction of postoperative seizure outcome. Read More

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http://dx.doi.org/10.1111/epi.14544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204289PMC
October 2018
14 Reads
4.571 Impact Factor

Techniques for placement of stereotactic electroencephalographic depth electrodes: Comparison of implantation and tracking accuracies in a cadaveric human study.

Epilepsia 2018 09 24;59(9):1667-1675. Epub 2018 Aug 24.

Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: Stereotactic electroencephalography (SEEG) is used for the evaluation and identification of the epileptogenic zone (EZ) in patients suffering from medically refractory seizures and relies upon the accurate implantation of depth electrodes. Accurate implantation is critical for identification of the EZ. Multiple electrodes and implantation systems exist, but these have not previously been systematically evaluated for implantation accuracy. Read More

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http://dx.doi.org/10.1111/epi.14538DOI Listing
September 2018
2 Reads

[Surgical treatment of epilepsy in patients with mediobasal temporal cavernous malformations].

Zh Vopr Neirokhir Im N N Burdenko 2018;82(4):45-56

Treatment and rehabilitation center, Moscow, Russia.

Objective: Epilepsy is a frequent clinical manifestation of cavernous malformations (CMs) of the mediobasal temporal region (MBTR). Surgical removal of CMs is an excellent technique for treating associated epilepsy and may range from pure lesionectomy to tailored resection of the temporal lobe.

Purpose: The study purpose was to determine the optimal surgical management for epilepsy in patients with CMs of the MBTR. Read More

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http://dx.doi.org/10.17116/neiro201882445DOI Listing
January 2018
30 Reads

Meyer's loop tractography for image-guided surgery depends on imaging protocol and hardware.

Neuroimage Clin 2018 13;20:458-465. Epub 2018 Aug 13.

Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom; School of Psychology, Faculty of Health Sciences, Australian Catholic University, Victoria, Australia.

Introduction: Surgical resection is an effective treatment for temporal lobe epilepsy but can result in visual field defects. This could be minimized if surgeons knew the exact location of the anterior part of the optic radiation (OR), the Meyer's loop. To this end, there is increasing prevalence of image-guided surgery using diffusion MRI tractography. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096050PMC
January 2019
1 Read

Enhanced co-registration methods to improve intracranial electrode contact localization.

Neuroimage Clin 2018 1;20:398-406. Epub 2018 Aug 1.

University of California Davis, Department of Biomedical Engineering, Davis, CA 95616, USA. Electronic address:

Background: Electrode contact locations are important when planning tailored brain surgeries to identify pathological tissue targeted for resection and conversely avoid eloquent tissue. Current methods employ trained experts to use neuroimaging scans that are manually co-registered and localize contacts within ~2 mm. Yet, the state of the art is limited by either the expertise needed for each type of intracranial electrode or the inter-modality co-registration which increases error, reducing accuracy. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095944PMC
January 2019
21 Reads

Deep learning applied to whole-brain connectome to determine seizure control after epilepsy surgery.

Epilepsia 2018 09 10;59(9):1643-1654. Epub 2018 Aug 10.

Department of Neurology, Medical University of South Carolina, Charleston, South Carolina.

Objective: We evaluated whether deep learning applied to whole-brain presurgical structural connectomes could be used to predict postoperative seizure outcome more accurately than inference from clinical variables in patients with mesial temporal lobe epilepsy (TLE).

Methods: Fifty patients with unilateral TLE were classified either as having persistent disabling seizures (SZ) or becoming seizure-free (SZF) at least 1 year after epilepsy surgery. Their presurgical structural connectomes were reconstructed from whole-brain diffusion tensor imaging. Read More

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http://doi.wiley.com/10.1111/epi.14528
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http://dx.doi.org/10.1111/epi.14528DOI Listing
September 2018
15 Reads

Distinguishing the precision of spatial recollection from its success: Evidence from healthy aging and unilateral mesial temporal lobe resection.

Neuropsychologia 2018 10 4;119:101-106. Epub 2018 Aug 4.

Department of Medical Social Sciences and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Successful episodic recollection can vary in the precision of the information recalled. The hypothesis that recollection precision requires functional neuroanatomical contributions distinct from those required for recollection success remains controversial. Some findings in individuals with hippocampal lesions have indicated that precision is dependent on the hippocampus. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2018.07.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191347PMC
October 2018

Clinical advances in photosensitive epilepsy.

Brain Res 2019 Jan 1;1703:18-25. Epub 2018 Aug 1.

Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. Electronic address:

Photosensitive epilepsy is the most common subset of reflex epilepsy in humans. It is characterized by an abnormal electroencephalogram trait known as photoparoxysmal response (PPR) corresponding to ictal symptomology in response to intermittent photic stimulation. Increased exposure to photic stimulation through technological and societal advance has had a significant impact on the incidence and interest in photosensitive epilepsy. Read More

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http://dx.doi.org/10.1016/j.brainres.2018.07.025DOI Listing
January 2019
1 Read

Unusual ictal propagation patterns suggesting poor prognosis after temporal lobe epilepsy surgery: Switch of lateralization and bilateral asynchrony.

Epilepsy Behav 2018 09 30;86:31-36. Epub 2018 Jul 30.

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: The objective of this study was to investigate unusual ictal propagation patterns in patients with drug-resistant temporal lobe epilepsy (TLE) and reveal their electrophysiological, neuroimaging, and prognostic properties after surgery.

Methods: Among 248 patients with TLE who underwent scalp video-electroencephalographic (EEG) monitoring, 24 patients with 'switch of lateralization' or 'bilateral asynchrony' in at least one of their seizures (9.3%) were analyzed retrospectively. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.07.013DOI Listing
September 2018
4 Reads

Contribution of Quantitative Amygdalar MR FLAIR Signal Analysis for Lateralization of Mesial Temporal Lobe Epilepsy.

J Neuroimaging 2018 Nov 1;28(6):666-675. Epub 2018 Aug 1.

Medical Image Analysis Laboratory, Henry Ford Health System, Detroit, MI.

Background And Purpose: This study evaluates the contribution of an automated amygdalar fluid-attenuated inversion recovery (FLAIR) signal analysis for the lateralization of mesial temporal lobe epilepsy (mTLE).

Methods: Sixty-nine patients (27 M, 42 F) who had undergone surgery and achieved an Engel class Ia postoperative outcome were identified as a pure cohort of mTLE cases. Forty-six nonepileptic subjects comprised the control group. Read More

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http://dx.doi.org/10.1111/jon.12549DOI Listing
November 2018

The impact of mapping interictal discharges using EEG-fMRI on the epilepsy presurgical clinical decision making process: A prospective study.

Seizure 2018 Oct 20;61:30-37. Epub 2018 Jul 20.

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, London, UK; MRI Unit, Epilepsy Society, Chalfont St. Peter, Buckinghamshire, UK.

Purpose: We set out to establish the clinical utility of EEG-correlated fMRI as part of the presurgical evaluation, by measuring prospectively its effects on the clinical decision.

Methods: Patients with refractory extra-temporal focal epilepsy, referred for presurgical evaluation were recruited in a period of 18 months. The EEG-fMRI based localization was presented during a multi-disciplinary meeting after the team had defined the presumed RESULTS: Sixteen patients (six women), with a median age of 28 years, were recruited. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.07.016DOI Listing
October 2018
4 Reads

IntrAnat Electrodes: A Free Database and Visualization Software for Intracranial Electroencephalographic Data Processed for Case and Group Studies.

Front Neuroinform 2018 6;12:40. Epub 2018 Jul 6.

Inserm, U1216, Grenoble Institut des Neurosciences (GIN), Grenoble, France.

In some cases of pharmaco-resistant and focal epilepsies, intracranial recordings performed epidurally (electrocorticography, ECoG) and/or in depth (stereoelectroencephalography, SEEG) can be required to locate the seizure onset zone and the eloquent cortex before surgical resection. In SEEG, each electrode contact records brain's electrical activity in a spherical volume of 3 mm diameter approximately. The spatial coverage is around 1% of the brain and differs between patients because the implantation of electrodes is tailored for each case. Read More

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https://www.frontiersin.org/article/10.3389/fninf.2018.00040
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http://dx.doi.org/10.3389/fninf.2018.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043781PMC
July 2018
13 Reads

Neuroimaging of Subacute Brain Inflammation and Microstructural Changes Predicts Long-Term Functional Outcome after Experimental Traumatic Brain Injury.

J Neurotrauma 2018 Oct 3. Epub 2018 Oct 3.

6 Laboratory of Experimental Hematology, Faculty of Medicine and Health Sciences, University of Antwerp , Wilrijk, Belgium .

There is currently a lack of prognostic biomarkers to predict the different sequelae following traumatic brain injury (TBI). The present study investigated the hypothesis that subacute neuroinflammation and microstructural changes correlate with chronic TBI deficits. Rats were subjected to controlled cortical impact (CCI) injury, sham surgery, or skin incision (naïve). Read More

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http://dx.doi.org/10.1089/neu.2018.5704DOI Listing
October 2018
14 Reads

Probabilistic functional tractography of the human cortex revisited.

Neuroimage 2018 11 17;181:414-429. Epub 2018 Jul 17.

Inserm, U1216, Grenoble, F-38000, France; Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, F-38000, France. Electronic address:

In patients with pharmaco-resistant focal epilepsies investigated with intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in distant cerebral cortex, which properties can be used to infer large scale brain connectivity. In 2013, we proposed a new probabilistic functional tractography methodology to study human brain connectivity. We have now been revisiting this method in the F-TRACT project (f-tract. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.07.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150949PMC
November 2018
13 Reads

Surgical resection of ripple onset predicts outcome in pediatric epilepsy.

Ann Neurol 2018 Sep 4;84(3):331-346. Epub 2018 Sep 4.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA.

Objective: In patients with medically refractory epilepsy (MRE), interictal ripples (80-250Hz) are observed in large brain areas whose resection may be unnecessary for seizure freedom. This limits their utility as epilepsy biomarkers for surgery. We assessed the spatiotemporal propagation of interictal ripples on intracranial electroencephalography (iEEG) in children with MRE, compared it with the propagation of spikes, identified ripples that initiated propagation (onset-ripples), and evaluated their clinical value as epilepsy biomarkers. Read More

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http://dx.doi.org/10.1002/ana.25295DOI Listing
September 2018
19 Reads

Unilateral temporal interictal epileptiform discharges correctly predict the epileptogenic zone in lesional temporal lobe epilepsy.

Epilepsia 2018 08 15;59(8):1577-1582. Epub 2018 Jul 15.

Epilepsy Center, Department of Neurology, University Hospital, Ludwig-Maximilians-University, Munich, Germany.

Objective: To evaluate the necessity of recording ictal electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE) considered for resective surgery who have unilateral temporal interictal epileptiform discharges (IEDs) and concordant ipsitemporal magnetic resonance imaging (MRI) pathology. To calculate the necessary number of recorded EEG seizure patterns (ESPs) to achieve adequate lateralization probability.

Methods: In a retrospective analysis, the localization and lateralization of interictal and ictal EEG of 304 patients with lesional TLE were analyzed. Read More

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http://dx.doi.org/10.1111/epi.14514DOI Listing
August 2018
6 Reads

Virtual localization of the seizure onset zone: Using non-invasive MEG virtual electrodes at stereo-EEG electrode locations in refractory epilepsy patients.

Neuroimage Clin 2018 2;19:758-766. Epub 2018 Jun 2.

Department of Neurology and Clinical Neurophysiology, Amsterdam, the Netherlands. Electronic address:

In some patients with medically refractory epilepsy, EEG with intracerebrally placed electrodes (stereo-electroencephalography, SEEG) is needed to locate the seizure onset zone (SOZ) for successful epilepsy surgery. SEEG has limitations and entails risk of complications because of its invasive character. Non-invasive magnetoencephalography virtual electrodes (MEG-VEs) may overcome SEEG limitations and optimize electrode placement making SOZ localization safer. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041424PMC
January 2019
13 Reads

Threshold and distribution of afterdischarges with electrical cortical stimulation.

J Clin Neurosci 2018 Sep 11;55:71-75. Epub 2018 Jul 11.

Department of Neurosurgery, Sapporo Medical University, Sapporo, Japan. Electronic address:

Objective: The present study aimed to investigate the threshold and distribution of afterdischarges (ADs) with cortical electrical stimulation for functional brain mapping.

Method: We retrospectively analyzed data from 11 patients with medically intractable epilepsy who underwent 50-Hz cortical electrical stimulation for functional mapping followed by resection. These patients became seizure free for more than six months. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.06.039DOI Listing
September 2018
1 Read

Age is but a number when considering epilepsy surgery in older adults.

Epilepsy Behav 2018 Jul 8. Epub 2018 Jul 8.

Department of Neurosurgery, Rush University Medical Center, Chicago, IL, USA.

Background: A quarter of patients with newly diagnosed epilepsy are older, yet they are less likely to be offered resective surgery potentially because of clinical bias that they incur increased surgical risks. There are few peer-reviewed case series that address this cohort and their outcomes.

Objective: In the context of current literature, the objective of this study was to report on all epilepsy surgeries in patients aged 50 years or older from a tertiary care center over 15 years with an average follow-up period of 6 years. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.05.022DOI Listing
July 2018
16 Reads

Intracranial neurenteric cyst arising at the suprasellar cistern with extension to middle cranial fossa.

Childs Nerv Syst 2018 Dec 6;34(12):2491-2495. Epub 2018 Jul 6.

Division of Pediatric Neurosurgery, Seoul National University College of Medicine, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110744, Republic of Korea.

Introduction: Intracranial neurenteric cysts are rare and are not often found in the supratentorial space. We present a case of an intracranial neurenteric cyst that arose at the suprasellar cistern with extension to the middle cranial fossa.

History: A 3-year-old girl presented with seizure. Read More

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http://dx.doi.org/10.1007/s00381-018-3892-9DOI Listing
December 2018
2 Reads

Analysis of shared heritability in common disorders of the brain.

Authors:
Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. Read More

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http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018
93 Reads
7 Citations
31.480 Impact Factor