2,990 results match your criteria Neuroimaging in Epilepsy Surgery


Multinodular and vacuolating neuronal tumour of the cerebrum: a rare neuroimaging incidentaloma or a potentially treatable cause of focal epilepsy?

Epileptic Disord 2019 Apr;21(2):209-214

Clinic of Neurology.

Multinodular and vacuolating neuronal tumour (MVNT) of the cerebrum is a relatively new, well defined histopathological and neuroradiological entity, in many cases associated with an early adult-onset epilepsy. These lesions have an indolent course and resemble both malformative and neoplastic processes, combining a focal developmental anomaly and a low-grade tumour. Herein, we report a case of a 48-year-old female patient with left temporal lobe epilepsy associated with MVNT. Read More

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http://dx.doi.org/10.1684/epd.2019.1045DOI Listing

The Role of FDG-PET in Patients with Epilepsy Related to Periventricular Nodular Heterotopias: Diagnostic Features and Long-Term Outcome.

J Neuroimaging 2019 Apr 22. Epub 2019 Apr 22.

Clinic of Radiology & Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Background And Purpose: Periventricular nodular heterotopias (PNHs) are frequently associated with drug-resistant epilepsy (DRE). Although magnetic resonance imaging (MRI) can define the morphological features of PNHs, still there is a need to assess their metabolic activity in order to provide useful information on epileptogenicity and long-term outcome. To that end, we investigated the ability of F-FDG PET to identify seizure onset zone in order to assess the metabolic activity of the ectopic neurons and to provide prognostic information on the postsurgical outcome. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12620
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http://dx.doi.org/10.1111/jon.12620DOI Listing
April 2019
1 Read

Focal Cortical Dysplasia and Refractory Epilepsy: Role of Multimodality Imaging and Outcome of Surgery.

AJNR Am J Neuroradiol 2019 Apr 18. Epub 2019 Apr 18.

Neurosurgery (M.P.), Krishna Institute of Medical Sciences, Secunderabad, India.

Background And Purpose: Focal cortical dysplasia (FCD) is one of the most common causes of drug resistant epilepsy. Our aim was to evaluate the role of presurgical noninvasive multimodality imaging techniques in selecting patients with refractory epilepsy and focal cortical dysplasia for epilepsy surgery and the influence of the imaging modalities on long-term seizure freedom.

Materials And Methods: We performed a retrospective analysis of data of 188 consecutive patients with FCD and refractory epilepsy with at least 2 years of postsurgery follow-up. Read More

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http://dx.doi.org/10.3174/ajnr.A6041DOI Listing
April 2019
1 Read

Determinants of IQ outcome after focal epilepsy surgery in childhood: A longitudinal case-control neuroimaging study.

Epilepsia 2019 Apr 10. Epub 2019 Apr 10.

Developmental Neurosciences Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.

Objective: Intelligence quotient (IQ) outcomes after pediatric epilepsy surgery show significant individual variation. Clinical factors such as seizure cessation or antiepileptic medication discontinuation have been implicated, but do not fully account for the heterogeneity seen. Less is known about the impact of neurobiological factors, such as brain development and resection location. Read More

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http://dx.doi.org/10.1111/epi.14707DOI Listing
April 2019
1 Read

Divergent network properties that predict early surgical failure versus late recurrence in temporal lobe epilepsy.

J Neurosurg 2019 04 5:1-10. Epub 2019 Apr 5.

Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center.

Objective: The objectives of this study were to identify functional and structural network properties that are associated with early versus long-term seizure outcomes after mesial temporal lobe epilepsy (mTLE) surgery and to determine how these compare to current clinically used methods for seizure outcome prediction.

Methods: In this case-control study, 26 presurgical mTLE patients and 44 healthy controls were enrolled to undergo 3-T MRI for functional and structural connectivity mapping across an 8-region network of mTLE seizure propagation, including the hippocampus (left and right), insula (left and right), thalamus (left and right), one midline precuneus, and one midline mid-cingulate. Seizure outcome was assessed annually for up to 3 years. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182875DOI Listing
April 2019
3 Reads
3.737 Impact Factor

Short-lasting retroorbital pain attacks as a form of ictal epileptic headache: Case report.

Cephalalgia 2019 Mar 16:333102419839792. Epub 2019 Mar 16.

1 Department of Clinical Neurophysiology, King's College Hospital, London, UK.

Background And Objectives: Ictal epileptic headache is a rare form of painful seizure, habitually consisting of migrainous or tension-type headache. We describe a case of a patient with short-lasting, severe retroorbital pain attacks caused by frontal lobe epilepsy.

Case Report: A 25-year-old male patient presented with recurrent attacks of paroxysmal, short-lasting, excruciating left periorbital and facial pain mainly occurring from sleep. Read More

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http://dx.doi.org/10.1177/0333102419839792DOI Listing
March 2019
1 Read

Morphological and Advanced Imaging of Epilepsy: Beyond the Basics.

Children (Basel) 2019 Mar 11;6(3). Epub 2019 Mar 11.

Unit of Neurodiagnostic, Division of Neuroradiology, Geneva University Hospital, rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.

The etiology of epilepsy is variable and sometimes multifactorial. Clinical course and response to treatment largely depend on the precise etiology of the seizures. Along with the electroencephalogram (EEG), neuroimaging techniques, in particular, magnetic resonance imaging (MRI), are the most important tools for determining the possible etiology of epilepsy. Read More

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https://www.mdpi.com/2227-9067/6/3/43
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http://dx.doi.org/10.3390/children6030043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462967PMC
March 2019
5 Reads

Social cognition in idiopathic generalized epilepsies and potential neuroanatomical correlates.

Epilepsy Behav 2019 Feb 26. Epub 2019 Feb 26.

Neurology Unit, Pisa University Hospital, Pisa, Italy. Electronic address:

Social cognition allows us to elaborate mental representations of social relationships and use them appropriately in a social environment. One of its main attributes is the so-called Theory of Mind (ToM), which consists of the ability to attribute beliefs, intentions, emotions, and feelings to self and others. Investigating social cognition may help understand the poor social outcome often experienced by persons with Idiopathic Generalized Epilepsies (IGE), who otherwise present with normal intelligence. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.003DOI Listing
February 2019
1 Read

Controlling seizure propagation in large-scale brain networks.

PLoS Comput Biol 2019 02 25;15(2):e1006805. Epub 2019 Feb 25.

Aix Marseille Université, Inserm, Institut de Neurosciences des Systèmes, UMR_S 1106, 13005, Marseille, France.

Information transmission in the human brain is a fundamentally dynamic network process. In partial epilepsy, this process is perturbed and highly synchronous seizures originate in a local network, the so-called epileptogenic zone (EZ), before recruiting other close or distant brain regions. We studied patient-specific brain network models of 15 drug-resistant epilepsy patients with implanted stereotactic electroencephalography (SEEG) electrodes. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405161PMC
February 2019
1 Read

Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Clin Neurophysiol 2019 Apr 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.009DOI Listing
April 2019
1 Read

Factors associated with early seizures after surgery of unruptured intracranial aneurysms.

Clin Neurol Neurosurg 2019 Mar 8;178:93-96. Epub 2019 Feb 8.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

Objective: The aim of the study was to better define the incidence of and risk factors for early seizures after repair of unruptured intracranial aneurysms in modern microsurgical techniques.

Patients And Methods: The medical records of 414 consecutive patients who underwent neck clipping of unruptured intracranial aneurysms in our institution over a 5-year period were retrospectively reviewed. Clinical and neuroimaging variables were analyzed to investigate putative predictors of perioperative seizures using multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.007DOI Listing
March 2019
1 Read

Comparing Single-Photon Emission Computed Tomography (SPECT), Electroencephalography (EEG), and Magneto-encephalography (MEG) Seizure Localizations in Pediatric Cases of Laser Ablation.

J Child Neurol 2019 May 12;34(6):303-308. Epub 2019 Feb 12.

3 University of Texas Dell Medical School, Austin, TX, USA.

Intractable epilepsy may have a more severe effect on children in comparison to adults because the motor, sensorial, and cognitive functions of children are still undergoing development. For this same reason, however, children maintain a greater potential for recovery from intractable epilepsy because of the remaining cerebral plasticity. Thus, after 2 unsuccessful antiepileptic medications, surgical intervention is recommended. Read More

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http://dx.doi.org/10.1177/0883073818822353DOI Listing
May 2019
1 Read

Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke.

JAMA Neurol 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Kantonsspital St Gallen, St Gallen, Switzerland.

Importance: Predicting the duration of poststroke dysphagia is important to guide therapeutic decisions. Guidelines recommend nasogastric tube (NGT) feeding if swallowing impairment persists for 7 days or longer and percutaneous endoscopic gastrostomy (PEG) placement if dysphagia does not recover within 30 days, but, to our knowledge, a systematic prediction method does not exist.

Objective: To develop and validate a prognostic model predicting swallowing recovery and the need for enteral tube feeding. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.4858DOI Listing
February 2019
29 Reads

Functional MRI and direct cortical stimulation: Prediction of postoperative language decline.

Epilepsia 2019 Mar 11;60(3):560-570. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients.

Methods: In this prospective case series, 17 patients with drug-resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 with 1-year follow-up. All patients completed preoperative language fMRI, mapping with DCS of subdural electrodes, pre- and postoperative neuropsychological testing for language function, and resection. Read More

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http://doi.wiley.com/10.1111/epi.14666
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http://dx.doi.org/10.1111/epi.14666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467056PMC
March 2019
23 Reads

Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation.

Epilepsy Res 2019 03 29;151:17-23. Epub 2019 Jan 29.

Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.011DOI Listing
March 2019
3 Reads

[Immediate outcomes of microsurgical treatment of cerebral arteriovenous malformations in non-hemorrhagic patients].

Zh Vopr Neirokhir Im N N Burdenko 2018;82(6):30-37

Burdenko Neurosurgical Institute, Moscow, Russia.

Arteriovenous malformations (AVMs) are some of the most frequent congenital abnormalities of the cerebral vascular system and usually occur at a young age. Given the fact that AVMs can manifest, in addition to hemorrhages, as symptomatic epilepsy (17-40%) that occurs more often at a young age and may lead to significant disability, investigation of this pathology remains topical. Particular attention has recently been paid to the management of AVM patients without clinical signs of hemorrhage at the time of pathology diagnosis. Read More

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http://dx.doi.org/10.17116/neiro20188206130DOI Listing
January 2018

[Subcortical calcification on CT in Borden type III intracranial dural arteriovenous fistula].

Rinsho Shinkeigaku 2019 Feb 31;59(2):93-97. Epub 2019 Jan 31.

Department of Neurology, Nissan Tamagawa Hospital.

We herein report a 67-year-old female who presented with progressive dementia and disturbance of consciousness. Brain CT showed multiple subcortical calcifications with edema. Enhanced CT showed multiple abnormal vessels in the left hemisphere. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001200DOI Listing
February 2019
7 Reads

The neurological and psychological phenotype of adult patients with early-treated phenylketonuria: A systematic review.

J Inherit Metab Dis 2019 Mar;42(2):209-219

Division of Inborn Metabolic Diseases, Department of Paediatrics, University Hospital, Padua, Italy.

Newborn screening for phenylketonuria (PKU) and early introduction of dietary therapy has been remarkably successful in preventing the severe neurological features of PKU, including mental retardation and epilepsy. However, concerns remain that long-term outcome is still suboptimal, particularly in adult patients who are no longer on strict phenylalanine-restricted diets. With our systematic literature review we aimed to describe the neurological phenotype of adults with early-treated phenylketonuria (ETPKU). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jimd.12065
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http://dx.doi.org/10.1002/jimd.12065DOI Listing
March 2019
12 Reads

Stereoelectroencephalography Versus Subdural Electrodes for Localization of the Epileptogenic Zone: What Is the Evidence?

Neurotherapeutics 2019 Jan;16(1):59-66

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, 15238, USA.

Accurate and safe localization of epileptic foci is the crux of surgical therapy for focal epilepsy. As an initial evaluation, patients with drug-resistant epilepsy often undergo evaluation by noninvasive methods to identify the epileptic focus (i.e. Read More

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http://dx.doi.org/10.1007/s13311-018-00703-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361059PMC
January 2019
1 Read

Changing temporal context in human temporal lobe promotes memory of distinct episodes.

Nat Commun 2019 01 14;10(1):203. Epub 2019 Jan 14.

Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal lobe as participants perform a verbal paired associates memory task that requires the encoding of distinct word pairs in memory. Read More

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http://dx.doi.org/10.1038/s41467-018-08189-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331638PMC
January 2019

Knowledge of language function and underlying neural networks gained from focal seizures and epilepsy surgery.

Brain Lang 2019 02 4;189:20-33. Epub 2019 Jan 4.

Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.

The effects of epilepsy and its treatments have contributed significantly to language models. The setting of epilepsy surgery, which allows for careful pre- and postsurgical evaluation of patients with cognitive testing and neuroimaging, has produced a wealth of language findings. Moreover, a new wave of surgical interventions, including stereotactic laser ablation and radio frequency ablation, have contributed new insights and corrections to language models as they can make extremely precise, focal lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093934X163009
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http://dx.doi.org/10.1016/j.bandl.2018.12.007DOI Listing
February 2019
7 Reads

Sudden unexpected death in epilepsy: The neuro-cardio-respiratory connection.

Seizure 2019 Jan 13;64:65-73. Epub 2018 Dec 13.

Athens University School of Medicine, Athens, Greece. Electronic address:

Sudden unexpected death in epilepsy (SUDEP) is the major cause of epilepsy-related premature mortality which targets preferentially younger people. Its etiology remains unknown. Several risk factors have been identified with generalized tonic-clonic seizures as the most important one; seizure control remains the most effective measure of prevention. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.12.007DOI Listing
January 2019
4 Reads

Mapping whole brain connectivity changes: The potential impact of different surgical resection approaches for temporal lobe epilepsy.

Cortex 2019 Apr 17;113:1-14. Epub 2018 Nov 17.

Neuroscience and Aphasia Research Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, UK. Electronic address:

In neurosurgery there are several situations that require transgression of the temporal cortex. For example, a subset of patients with temporal lobe epilepsy require surgical resection (most typically, en-bloc anterior temporal lobectomy). This procedure is the gold standard to alleviate seizures but is associated with chronic cognitive deficits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00109452183037
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http://dx.doi.org/10.1016/j.cortex.2018.11.003DOI Listing
April 2019
6 Reads

Comparison of Methods to Identify Modules in Noisy or Incomplete Brain Networks.

Brain Connect 2019 03 28;9(2):128-143. Epub 2019 Feb 28.

1 Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Finland.

Community structure, or "modularity," is a fundamentally important aspect in the organization of structural and functional brain networks, but their identification with community detection methods is confounded by noisy or missing connections. Although several methods have been used to account for missing data, the performance of these methods has not been compared quantitatively so far. In this study, we compared four different approaches to account for missing connections when identifying modules in binary and weighted networks using both Louvain and Infomap community detection algorithms. Read More

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http://dx.doi.org/10.1089/brain.2018.0603DOI Listing

Imaging episodic memory during development and childhood epilepsy.

J Neurodev Disord 2018 Dec 13;10(1):40. Epub 2018 Dec 13.

Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Avenue NW, Washington, D.C., 20010, USA.

Epilepsy affects 2.2 million adults in the USA, with 1 in 26 people developing epilepsy at some point in their lives. Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy as medial structures, and the hippocampus in particular, are prone to generating seizures. Read More

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http://dx.doi.org/10.1186/s11689-018-9255-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292091PMC
December 2018

Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2019 Jan 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183074
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http://dx.doi.org/10.1016/j.yebeh.2018.10.033DOI Listing
January 2019
23 Reads
2.257 Impact Factor

Title.

Hong Kong Med J 2018 Nov 27. Epub 2018 Nov 27.

Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital, Yaumatei, Hong Kong.

Epilepsy is defined as drug-resistant after failure of two adequate trials of appropriately chosen and administered antiepileptic drugs. Approximately 30% of patients with epilepsy have drug-resistant epilepsy. Reasons for treatment failure include failure to recognise epilepsy syndrome, poor drug compliance, and lifestyle factors. Read More

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http://dx.doi.org/10.12809/hkmj187285DOI Listing
November 2018

Discrimination of epileptogenic lesions and perilesional white matter using diffusion tensor magnetic resonance imaging.

Neuroradiol J 2019 Feb 21;32(1):10-16. Epub 2018 Nov 21.

1 Department of Neuroradiology, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

The aim of this study was to evaluate whether ganglioglioma (GGL), dysembryoplastic neuroepithelial tumour (DNET) and FCD (focal cortical dysplasia) are distinguishable through diffusion tensor imaging. Additionally, it was investigated whether the diffusion measures differed in the perilesional (pNAWM) and in the contralateral normal appearing white matter (cNAWM). Six GGLs, eight DNETs and seven FCDs were included in this study. Read More

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http://dx.doi.org/10.1177/1971400918813991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327366PMC
February 2019
4 Reads

Neurologic phenotypes associated with / mutations: Expanding the spectrum of disease.

Neurology 2018 Nov 9;91(22):e2078-e2088. Epub 2018 Nov 9.

From the Department of Clinical and Experimental Epilepsy (S.Z., Z.M., L.H.-H., S.K., S. Balestrini, S.M.S.) and Division of Neuropathology (Z.M., M.T.), UCL Institute of Neurology, London, UK; Clinic of Neurology (S.Z.), Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy; Department of Pediatric Neurology and Neurological Rehabilitation (C.S., T.H., P.W., G.J.K.) and Neurosurgery Clinic and Clinic for Epilepsy Surgery (M.K.), Schön Klinik Vogtareuth; Department of Pediatrics (C.S., M.S.), Children's Hospital Augsburg, Germany; UCL Great Ormond Street Institute of Child Health (J.R.N., K.V., S.M.V., J.H.C.), London, UK; Paediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G.), A. Meyer Children's Hospital, University of Florence, Italy; Chalfont Centre for Epilepsy (Z.M., L.H.-H., S.K., S. Balestrini, S.M.S.), Chalfont-St-Peter, Buckinghamshire, UK; CeGaT-Center for Genomics and Transcriptomics (A.P., S. Biskup), Tübingen, Germany; Neurogenetics Unit (M.L.), Department of Medical Genetics, Hospital de São João, Porto, Portugal; Department of Pediatrics and Adolescent Medicine (J.G.), University Medical Center Göttingen; Hospital for Children and Adolescents (A.M.), University Clinic Leipzig, Germany; Freiburg Medical Laboratory (M.J.), Dubai; The Danish Epilepsy Centre (R.S.M., E.G.), Dianalund; Institute for Regional Health Services (R.S.M., E.G.), University of Southern Denmark, Odense; Department of Clinical Genetics (B.S.K.), Odense University Hospital; Hans Christian Andersen Children's Hospital (L.K.H.), Odense, Denmark; Pediatric Neurology and Muscular Diseases Unit (M.S.V., P.S.), Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa "G. Gaslini" Institute, Italy; Division of Neurology (K.L.H.), Children's Hospital of Philadelphia, PA; Department of Neurology (S.D., C.L.S.-H.), Division of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD; Center for Genomic Medicine (N.H.-F.), Tohoku University; Department of Pediatrics (N.H.-F.), Tohoku University School of Medicine, Sendai, Japan; Department of Pediatrics (T.T., R.L.) and Institute of Clinical Medicine (K.O.), University of Tartu; Children's Clinic (T.T., R.L.), Department of Radiology (P.I.), and Department of Clinical Genetics, United Laboratories (K.O.), Tartu University Hospital, Estonia; Ludwig-Maximilians-University Munich (I.K.); Department of Pediatric Neurology (A.H.), Clinic Traunstein; Children's Hospital (M.K.), Dr. Horst Schmidt Klinik, Wiesbaden; Altona Children's Hospital (J.H.), Hamburg; Department of Pediatrics (C. Makowski), Technische Universität München, Germany; Department of Clinical Genetics (S.G.), Royal North Shore Hospital, St Leonards; John Hunter Children's Hospital (G.M.S.), New Lambton Heights, New South Wales, Australia; Department of Neurology (R.T.), University Hospital of Wales; Institute of Psychological Medicine and Clinical Neurosciences (R.H.T.), Cardiff University; Division of Neuroradiology (C. Micallef), National Hospital for Neurology and Neurosurgery, London; Department of Brain Repair & Rehabilitation (D.J.W.), Stroke Research Centre, UCL Institute of Neurology, London, UK; Paracelsus Medical University (G.J.K.), Salzburg, Austria; and IRCCS Stella Maris Foundation (R.G.), Pisa, Italy.

Objective: To characterize the neurologic phenotypes associated with mutations and to seek genotype-phenotype correlation.

Methods: We analyzed clinical, EEG, and neuroimaging data of 44 new and 55 previously reported patients with mutations.

Results: Childhood-onset focal seizures, frequently complicated by status epilepticus and resistance to antiepileptic drugs, was the most common phenotype. Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282239PMC
November 2018
20 Reads

Diagnostic accuracy of functional magnetic resonance imaging, Wada test, magnetoencephalography, and functional transcranial Doppler sonography for memory and language outcome after epilepsy surgery: A systematic review.

Epilepsia 2018 12 30;59(12):2305-2317. Epub 2018 Oct 30.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.

Objective: The European Union-funded E-PILEPSY project was launched to develop guidelines and recommendations for epilepsy surgery. In this systematic review, we aimed to assess the diagnostic accuracy of functional magnetic resonance imaging (fMRI), Wada test, magnetoencephalography (MEG), and functional transcranial Doppler sonography (fTCD) for memory and language decline after surgery.

Methods: The literature search was conducted using PubMed, Embase, and CENTRAL. Read More

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http://doi.wiley.com/10.1111/epi.14588
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http://dx.doi.org/10.1111/epi.14588DOI Listing
December 2018
3 Reads

Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future.

J Korean Med Sci 2018 Oct 4;33(44):e279. Epub 2018 Oct 4.

Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Magnetic resonance-guided focused ultrasound (MRgFUS) is a new emerging neurosurgical procedure applied in a wide range of clinical fields. It can generate high-intensity energy at the focal zone in deep body areas without requiring incision of soft tissues. Although the effectiveness of the focused ultrasound technique had not been recognized because of the skull being a main barrier in the transmission of acoustic energy, the development of hemispheric distribution of ultrasound transducer phased arrays has solved this issue and enabled the performance of true transcranial procedures. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200905PMC
October 2018
2 Reads
1.253 Impact Factor

[Initial Experience of Stereotactic EEG Insertion with Anchor Bolt:Problem Extraction and Improvement of Insertion Accuracy].

No Shinkei Geka 2018 Oct;46(10):917-924

Department of Neurosurgery, Kyoto University Graduate School of Medicine.

In recent years, stereotactic electroencephalography(SEEG)has been focused on as a new invasive method for epileptic focus detection. Although the covering area of the brain surface is smaller than the invasive estimation with subdural electrodes, SEEG can evaluate foci that are deeply seated, noncontiguous leaves, and/or bilateral hemispheres. In addition, SEEG can capture consecutive changes in seizure activity in three dimensions. Read More

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http://dx.doi.org/10.11477/mf.1436203839DOI Listing
October 2018
19 Reads

Stimulation-induced ictal vocalisation of left frontal lobe origin.

Epileptic Disord 2018 Oct;20(5):418-422

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

Pure ictal non-speech vocalisation occurs in frontal and temporal lobe epilepsies. Electrical stimulation of supplementary motor areas is reported to evoke vocalisation in selected patients. Here, we report a patient with focal epilepsy of the left anterior insula who had isolated monotonous vocalisation elicited by electrical stimulation of the left superior frontal gyrus. Read More

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http://dx.doi.org/10.1684/epd.2018.0990DOI Listing
October 2018
17 Reads

A web-based diagnostic reference centre for the European Reference Network "EpiCare": recommendations of the eNeuropathology working group.

Epileptic Disord 2018 Oct;20(5):339-345

Neuropathologisches Institut, Universitätsklinikum Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany.

Epilepsy surgery is a valuable treatment strategy for a selected group of patients with drug-resistant focal epilepsy. While reliable disease classification is essential for the optimal management of patients in general and crucial for the development of more personalized therapies in the future, arriving at a precise diagnosis often poses considerable difficulties due to the broad and variant-rich spectrum of epilepsy-associated brain lesions. Given the scarcity of European institutions diagnostically focusing on the histopathology of epilepsy surgery cases, the provision of subspecialty expertise as well as training opportunities remains logistically and financially challenging. Read More

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http://dx.doi.org/10.1684/epd.2018.1002DOI Listing
October 2018
14 Reads

BOLD mapping of human epileptic spikes recorded during simultaneous intracranial EEG-fMRI: The impact of automated spike classification.

Neuroimage 2019 01 10;184:981-992. Epub 2018 Oct 10.

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, United Kingdom; MRI Unit, Epilepsy Society, Chalfont St Peter, Buckinghamshire, United Kingdom. Electronic address:

Objectives: Simultaneous intracranial EEG and functional MRI (icEEG-fMRI) can be used to map the haemodynamic (BOLD) changes associated with the generation of IEDs. Unlike scalp EEG-fMRI, in most patients who undergo icEEG-fMRI, IEDs recorded intracranially are numerous and show variability in terms of field amplitude and morphology. Therefore, visual marking can be highly subjective and time consuming. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183193
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http://dx.doi.org/10.1016/j.neuroimage.2018.09.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264381PMC
January 2019
15 Reads

Automated EEG source imaging: A retrospective, blinded clinical validation study.

Clin Neurophysiol 2018 Nov 24;129(11):2403-2410. Epub 2018 Sep 24.

Department of Clinical Neurophysiology, Danish Epilepsy Centre, Visby Allé 5, 4293 Dianalund, Denmark; Department of Clinical Neurophysiology, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus, Denmark. Electronic address:

Objective: To evaluate the accuracy of automated EEG source imaging (ESI) in localizing epileptogenic zone.

Methods: Long-term EEG, recorded with the standard 25-electrode array of the IFCN, from 41 consecutive patients with focal epilepsy who underwent resective surgery, were analyzed blinded to the surgical outcome. The automated analysis comprised spike-detection, clustering and source imaging at the half-rising time and at the peak of each spike-cluster, using individual head-models with six tissue-layers and a distributed source model (sLORETA). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.09.015DOI Listing
November 2018
2 Reads

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction.

Front Neurosci 2018 11;12:628. Epub 2018 Sep 11.

Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.

High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein released by glia and neurons upon inflammasome activation and activates receptor for advanced glycation end products (RAGE) and toll-like receptor (TLR) 4 on the target cells. HMGB1/TLR4 axis is a key initiator of neuroinflammation. In recent days, more attention has been paid to HMGB1 due to its contribution in traumatic brain injury (TBI), neuroinflammatory conditions, epileptogenesis, and cognitive impairments and has emerged as a novel target for those conditions. Read More

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https://www.frontiersin.org/article/10.3389/fnins.2018.00628
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http://dx.doi.org/10.3389/fnins.2018.00628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142787PMC
September 2018
2 Reads

Distinctive epileptogenic networks for parietal operculum seizures.

Epilepsy Behav 2019 Feb 27;91:59-67. Epub 2018 Sep 27.

Epilepsy Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China. Electronic address:

Objective: The present study investigated the electroclinical features and epileptogenic networks of parietal operculum seizures (POS) by using stereoelectroencephalography (SEEG) intracerebral recordings.

Methods: Comprehensive presurgical evaluation data of seven patients with drug-resistant epilepsy with POS were analyzed retrospectively. Stereoelectroencephalography-recorded seizures were processed visually and quantitatively by using epileptogenicity mapping (EM), which has been proposed to ergonomically quantify the epileptogenicity of brain structures with a neuroimaging approach. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183025
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http://dx.doi.org/10.1016/j.yebeh.2018.08.031DOI Listing
February 2019
8 Reads

Human herpesvirus 6 associated post-transplant acute limbic encephalitis: Clinical observations of biomarkers for risk of seizure in a pediatric population.

Transpl Infect Dis 2019 Feb 15;21(1):e13003. Epub 2018 Oct 15.

Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts.

Background: Human herpesvirus 6 (HHV6) is a cause of post-transplant acute limbic encephalitis (PALE). Seizures are associated with this disorder yet no predictive biomarkers have been identified. The objective of this study was to evaluate lab and neurodiagnostic biomarkers in patients with HHV6 associated PALE. Read More

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http://doi.wiley.com/10.1111/tid.13003
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http://dx.doi.org/10.1111/tid.13003DOI Listing
February 2019
9 Reads

Application of Awake Surgery for Epilepsy in Clinical Practice.

Neurol Med Chir (Tokyo) 2018 Oct 21;58(10):442-452. Epub 2018 Sep 21.

Department of Neurosurgery, Nagoya University School of Medicine.

Epilepsy surgery aims to control epilepsy by resecting the epileptogenic region while preserving function. In some patients with epileptogenic foci in and around functionally eloquent areas, awake surgery is implemented. We analyzed the surgical outcomes of such patients and discuss the clinical application of awake surgery for epilepsy. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186762PMC
October 2018
7 Reads

Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy.

Neuroimage Clin 2018 15;20:742-752. Epub 2018 Sep 15.

IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Epilepsy Unit, Department of Radiology, Hospital Clínic, Barcelona, Spain.

Chronic exposure to seizures in patients with left hemisphere (LH) epileptic focus could favor higher activation in the contralateral hemisphere during language processing, but the cognitive effects of this remain unclear. This study assesses the relationship between asymmetry in hemispheric activation during language fMRI and performance in verbal and non-verbal tasks. Whereas prior studies primarily used fMRI paradigms that favor frontal lobe activation and less prominent activation of the medial or superior temporal lobes, we used a verbal comprehension paradigm previously demonstrated to activate reliably receptive language areas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183028
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http://dx.doi.org/10.1016/j.nicl.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154460PMC
January 2019
21 Reads

Pre-Surgical Planning: Multimodality Imaging to Optimize Outcomes in Pediatric Epilepsy Surgery.

Authors:
Timothy P Zinkus

Mo Med 2018 Jul-Aug;115(4):365-367

Timothy P. Zinkus, MD, is Assistant Professor, Pediatric Radiology, Children's Mercy, University of Missouri, Kansas City, Kansas City, Mo.

Neuroimaging is an important component of the pre-surgical planning for pediatric epilepsy. High-resolution structural magnetic resonance images are combined with advanced structural and functional imaging techniques to better define the surgical lesion and decrease morbidity postoperatively. The combination of neuroimaging, electroencephalography (EEG), and neuropsychiatric testing in a multidisciplinary epilepsy conference setting is essential for determining a plan for surgical management. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140251PMC
September 2018
1 Read

Mood variations decoded from multi-site intracranial human brain activity.

Nat Biotechnol 2018 11 10;36(10):954-961. Epub 2018 Sep 10.

Ming Hsieh Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.

The ability to decode mood state over time from neural activity could enable closed-loop systems to treat neuropsychiatric disorders. However, this decoding has not been demonstrated, partly owing to the difficulty of modeling distributed mood-relevant neural dynamics while dealing with the sparsity of mood state measurements. Here we develop a modeling framework to decode mood state variations from multi-site intracranial recordings in seven human subjects with epilepsy who self-reported their mood state intermittently over multiple days. Read More

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http://dx.doi.org/10.1038/nbt.4200DOI Listing
November 2018

Multimodal localization and surgery for epileptic spasms of focal origin: a review.

Neurosurg Focus 2018 Sep;45(3):E4

1Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

Epileptic spasms (ES) are a common manifestation of intractable epilepsy in early life and can lead to devastating neurodevelopmental consequences. Epilepsy surgery for ES is challenging because of inherent difficulties in localizing the epileptogenic zone in affected infants and children. However, recent clinical series of resective neurosurgery for ES suggest that not only is surgery a viable option for appropriately selected patients, but postoperative seizure outcomes can be similar to those achieved in other types of focal epilepsy. Read More

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http://dx.doi.org/10.3171/2018.6.FOCUS18217DOI Listing
September 2018
3 Reads

Phase-amplitude coupling between interictal high-frequency activity and slow waves in epilepsy surgery.

Epilepsia 2018 10 26;59(10):1954-1965. Epub 2018 Aug 26.

Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan.

Objective: We hypothesized that the modulation index (MI), a summary measure of the strength of phase-amplitude coupling between high-frequency activity (>150 Hz) and the phase of slow waves (3-4 Hz), would serve as a useful interictal biomarker for epilepsy presurgical evaluation.

Methods: We investigated 123 patients who underwent focal cortical resection following extraoperative electrocorticography recording and had at least 1 year of postoperative follow-up. We examined whether consideration of MI would improve the prediction of postoperative seizure outcome. Read More

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http://dx.doi.org/10.1111/epi.14544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204289PMC
October 2018
20 Reads
4.571 Impact Factor

Techniques for placement of stereotactic electroencephalographic depth electrodes: Comparison of implantation and tracking accuracies in a cadaveric human study.

Epilepsia 2018 09 24;59(9):1667-1675. Epub 2018 Aug 24.

Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: Stereotactic electroencephalography (SEEG) is used for the evaluation and identification of the epileptogenic zone (EZ) in patients suffering from medically refractory seizures and relies upon the accurate implantation of depth electrodes. Accurate implantation is critical for identification of the EZ. Multiple electrodes and implantation systems exist, but these have not previously been systematically evaluated for implantation accuracy. Read More

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http://dx.doi.org/10.1111/epi.14538DOI Listing
September 2018
2 Reads

[Surgical treatment of epilepsy in patients with mediobasal temporal cavernous malformations].

Zh Vopr Neirokhir Im N N Burdenko 2018;82(4):45-56

Treatment and rehabilitation center, Moscow, Russia.

Objective: Epilepsy is a frequent clinical manifestation of cavernous malformations (CMs) of the mediobasal temporal region (MBTR). Surgical removal of CMs is an excellent technique for treating associated epilepsy and may range from pure lesionectomy to tailored resection of the temporal lobe.

Purpose: The study purpose was to determine the optimal surgical management for epilepsy in patients with CMs of the MBTR. Read More

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http://dx.doi.org/10.17116/neiro201882445DOI Listing
February 2019
45 Reads

Meyer's loop tractography for image-guided surgery depends on imaging protocol and hardware.

Neuroimage Clin 2018 13;20:458-465. Epub 2018 Aug 13.

Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom; School of Psychology, Faculty of Health Sciences, Australian Catholic University, Victoria, Australia.

Introduction: Surgical resection is an effective treatment for temporal lobe epilepsy but can result in visual field defects. This could be minimized if surgeons knew the exact location of the anterior part of the optic radiation (OR), the Meyer's loop. To this end, there is increasing prevalence of image-guided surgery using diffusion MRI tractography. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096050PMC
January 2019
2 Reads

Enhanced co-registration methods to improve intracranial electrode contact localization.

Neuroimage Clin 2018 1;20:398-406. Epub 2018 Aug 1.

University of California Davis, Department of Biomedical Engineering, Davis, CA 95616, USA. Electronic address:

Background: Electrode contact locations are important when planning tailored brain surgeries to identify pathological tissue targeted for resection and conversely avoid eloquent tissue. Current methods employ trained experts to use neuroimaging scans that are manually co-registered and localize contacts within ~2 mm. Yet, the state of the art is limited by either the expertise needed for each type of intracranial electrode or the inter-modality co-registration which increases error, reducing accuracy. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095944PMC
January 2019
30 Reads

Brain network alterations of mesial temporal lobe epilepsy with cognitive dysfunction following anterior temporal lobectomy.

Epilepsy Behav 2018 10 13;87:123-130. Epub 2018 Aug 13.

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China. Electronic address:

The aims of this study were to investigate the brain network connectivity alterations of intractable unilateral mesial temporal lobe epilepsy (MTLE) with cognitive dysfunction before and after anterior temporal lobectomy (ATL) using resting-state functional magnetic resonance imaging (rs-fMRI) study and to further observe the correlation between the brain network connectivity with cognitive performance. Fourteen patients with unilateral left MTLE before and after ATL were compared with thirty healthy controls (HCs) on functional connectivity (FC) between resting-state networks (RSNs). The correlation between the neuropsychological tests of patients and abnormal FC was further investigated. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.07.021DOI Listing
October 2018
8 Reads
2.260 Impact Factor