930 results match your criteria Neurogastroenterology & Motility[Journal]


Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner.

Brain Behav Immun 2019 Mar 11. Epub 2019 Mar 11.

Univ. Bordeaux, INRA, Nutrition and Integrative Neurobiology, UMR 1286, 33076 Bordeaux, France; INRA, Nutrition and Integrative Neurobiology, UMR 1286, 33076 Bordeaux, France. Electronic address:

The accumulation of adverse events in utero and during childhood differentially increases the vulnerability to psychiatric diseases in men and women. Gut microbiota is highly sensitive to the early environment and has been recently hypothesized to affect brain development. However, the impact of early-life adversity on gut microbiota, notably with regards to sex differences, remains to be explored. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.03.006DOI Listing

Non-celiac gluten or wheat sensitivity: It's complicated!

Neurogastroenterol Motil 2018 Aug;30(8):e13392

Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.

In the last 30 years, non-celiac gluten sensitivity (NCGS) has emerged as an intriguing and controversial topic in gastroenterology. The diagnosis of NCGS/NCWS requires a symptomatic reaction to gluten, or wheat-containing food, and remission of symptoms with gluten or wheat challenge, in patients in whom celiac disease and wheat allergy have been excluded. There have been several randomized clinical trials (RCT) addressing this issue which have produced controversial results. Read More

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http://dx.doi.org/10.1111/nmo.13392DOI Listing

[Irritable Bowel Syndrome].

Korean J Gastroenterol 2019 Feb;73(2):84-91

Department of Internal Medicine, Inje University College of Medicine, Busan, Korea.

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Its diagnosis is based on symptoms, and the Rome IV criteria are recognized as the gold diagnostic standard. The Korean Society of Neurogastroenterology and Motility (KSNM) recently updated their clinical practice guidelines for the treatment of IBS, which were last issued in 2011. Read More

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http://dx.doi.org/10.4166/kjg.2019.73.2.84DOI Listing
February 2019
3 Reads

Measurement of novel intestinal secretory and barrier pathways and effects of proteases.

Neurogastroenterol Motil 2019 Apr;31(4):e13547

Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota.

The epithelial lining of the gastrointestinal (GI) tract in conjunction with the enteric nervous system (ENS) plays an important role in mediating solute absorption and secretion. A dysregulated ionic movement across the epithelium can result in GI diseases that manifest as either watery diarrhea or constipation. Hirschsprung disease is an example of an ENS disorder characterized by absence of enteric ganglia in distal gut resulting in obstructive phenotype. Read More

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http://dx.doi.org/10.1111/nmo.13547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407641PMC
April 2019
2 Reads

Evidence for Local and Systemic Immune Activation in Functional Dyspepsia and the Irritable Bowel Syndrome: A Systematic Review.

Am J Gastroenterol 2019 Mar;114(3):429-436

School of Biomedical Sciences & Pharmacy, Faculty of Health & Medicine, University of Newcastle, Newcastle, NSW, Australia.

Background: Subtle histopathologic features such as eosinophilia and increased mast cells have been observed in functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD) and the irritable bowel syndrome (IBS). The mechanisms that drive recruitment of these cells to the gastrointestinal tract remain unexplained, largely due to the heterogeneity in phenotypes among patients diagnosed with such conditions. We aimed to systematically review the literature and collate the evidence for immune activation in FD and IBS, and where possible, detail the nature of activation. Read More

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http://dx.doi.org/10.1038/s41395-018-0377-0DOI Listing
March 2019
1 Read

Spatio-temporal motility MRI analysis of the stomach and colon.

Neurogastroenterol Motil 2019 Feb 28:e13557. Epub 2019 Feb 28.

Centre for Medical Imaging, UCL, London, UK.

Background: MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do not offer insights into the nature of contractile action. This study introduces a systematic method of making spatio-temporal measurements of contractions, based on changes in bowel lumen diameter. Read More

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http://dx.doi.org/10.1111/nmo.13557DOI Listing
February 2019

Gut-focused hypnotherapy for Functional Gastrointestinal Disorders: Evidence-base, practical aspects, and the Manchester Protocol.

Neurogastroenterol Motil 2019 Feb 27:e13573. Epub 2019 Feb 27.

Neurogastroenterology Unit, Gastroenterology, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Background: Despite their high prevalence and advances in the field of neurogastroenterology, there remain few effective treatment options for functional gastrointestinal disorders (FGIDs). It is recognized that approximately 25% of sufferers will have symptoms refractory to existing therapies, causing significant adverse effects on quality of life and increased healthcare utilization and morbidity. Gut-focused hypnotherapy, when delivered by trained therapists, has been shown to be highly effective in severe refractory FGIDs. Read More

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http://doi.wiley.com/10.1111/nmo.13573
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http://dx.doi.org/10.1111/nmo.13573DOI Listing
February 2019
3 Reads

Anti-muscarinic drugs increase rectal compliance and exacerbate constipation in chronic spinal cord injury : Anti-muscarinic drug effect on neurogenic bowel.

Spinal Cord 2019 Feb 25. Epub 2019 Feb 25.

Department of GI Physiology, University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.

Study Design: Prospective cohort study OBJECTIVES: We hypothesized that anti-muscarinic agents alter rectal compliance in SCI patients and that altered rectal compliance relates to bowel symptomatology. Our primary aim was to compare rectal compliance before and after the institution of anti-muscarinics (solifenacin and tolterodine) and an adrenoceptor agonist (mirabegron) in these patients. Additionally, we wanted to evaluate if anorectal manometry differed before and after use of anti-muscarinic agents. Read More

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http://dx.doi.org/10.1038/s41393-019-0263-7DOI Listing
February 2019
2 Reads

Necrotizing enterocolitis.

Neurogastroenterol Motil 2019 Mar;31(3):e13569

Department of Pediatrics and Human Development, Division of Neonatology, Michigan State University, East Lansing, Michigan.

Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the intestine which primarily affects preterm infants and is a leading cause of morbidity and mortality in the neonatal intensive care unit. From a clinical standpoint, and during the early course of the disease, NEC can be difficult to distinguish from other diseases and conditions common to the preterm infant, and this warrants the need for specific disease biomarkers. The pathogenesis of NEC is only partly understood but likely involves an altered intestinal barrier immune response to feeding and the developing microbiome. Read More

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http://dx.doi.org/10.1111/nmo.13569DOI Listing

The American neurogastroenterology and motility society gastroparesis cardinal symptom index-daily diary (ANMS GCSI-DD): Psychometric evaluation in patients with idiopathic or diabetic gastroparesis.

Neurogastroenterol Motil 2019 Apr 7;31(4):e13553. Epub 2019 Feb 7.

Temple University Hospital, Philadelphia, Pennsylvania.

Background: The purpose of this study was to evaluate the measurement properties of the American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index-Daily Diary, a patient-reported outcome instrument developed to meet US FDA recommendations for a symptom-based clinical trial endpoint in gastroparesis. The ANMS GCSI-DD assesses nausea, early satiety, postprandial fullness, and upper abdominal pain on a severity score from none (0) to very severe (4) and number of vomiting episodes during the past 24 hours. The composite score includes the first four symptoms, the core symptom score includes all five symptoms. Read More

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http://dx.doi.org/10.1111/nmo.13553DOI Listing
April 2019
2 Reads

SKYPE HYPNOTHERAPY FOR IRRITABLE BOWEL SYNDROME: Effectiveness and Comparison with Face-to-Face Treatment.

Int J Clin Exp Hypn 2019 Jan-Mar;67(1):69-80

a Neurogastroenterology Unit , Wythenshawe Hospital , Manchester , UK.

Gut-focused hypnotherapy is an effective treatment for irritable bowel syndrome but is not widely available. This study assessed whether providing hypnotherapy by Skype might partially overcome this problem. Using a 50-point or more reduction in the IBS Symptom Severity Score as the primary outcome measure, 65% of subjects responded to Skype hypnotherapy with all other outcomes significantly improving. Read More

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http://dx.doi.org/10.1080/00207144.2019.1553766DOI Listing
February 2019
2 Reads

Comment on: "Pitfalls in the measurement of muscle mass: a need for a reference standard" by Buckinx et al.

J Cachexia Sarcopenia Muscle 2018 Dec 24;9(7):1269-1271. Epub 2019 Jan 24.

Institute on Aging, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1002/jcsm.12372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351671PMC
December 2018

A novel serotonin-containing tuft cell subpopulation in mouse intestine.

Cell Tissue Res 2019 Jan 21. Epub 2019 Jan 21.

Department of Experimental Medical Science, Unit of Neurogastroenterology, Lund University, Sölvegatan 19, BMC B11, SE-22184, Lund, Sweden.

In this study, a novel subset of doublecortin-like kinase 1 (DCLK1)-immunoreactive (IR) tuft cells that also contain serotonin (5-hydroxytryptamine, 5HT) is described, in terms of their number, regional distribution, possible synthesis or reuptake of 5HT and proximity to 5-HT-containing enterochromaffin (EC) cells. The small intestine from C57BL/6J mice was divided into five segments while the large intestine was kept undivided. Double immunostaining was used to estimate numbers and topographic distribution of 5HT-IR (DCLK1/5HT) tuft cells and their possible expression of tryptophan hydroxylase (TPH) and serotonin transporter (SERT). Read More

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http://dx.doi.org/10.1007/s00441-018-02988-3DOI Listing
January 2019
1 Read

Barriers in Neurogastroenterology and Motility Training Experience for Pediatric Gastroenterology Fellows.

J Pediatr Gastroenterol Nutr 2019 Jan 17. Epub 2019 Jan 17.

Division of Pediatric Gastroenterology, Children's Hospital of Philadelphia, Philadelphia, PA.

Background: Neurogastroenterology and motility (NGM) disorders are common and have a high health care burden. Although pediatric gastroenterology fellows are expected to obtain comprehensive training in the diagnosis and management of NGM disorders, there is ongoing concern for unmet training needs and lack of exposure in treating patients who suffer from NGM problems.

Study Design: We conducted a cross-section survey of trainees listed as pediatric gastroenterology fellows in North American training programs in 2018 via direct E-mail and the pediatric gastroenterology listserv. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002282DOI Listing
January 2019
6 Reads

Medical Professionals' Review of YouTube Videos Pertaining to Exercises for the Constipation Relief.

Korean J Gastroenterol 2018 Dec;72(6):295-303

Department of Biostatistics, Soonchunhyang University Seoul Hospital, Seoul, Korea.

Background/aims: The primary aims of this study were to evaluate the content quality of YouTube videos on exercises to help relieve constipation and to assess whether the video source, exercise types, and popularity affected their quality.

Methods: Eight gastroenterologists independently evaluated the exercises presented in the constipation YouTube videos for seven items: image quality, usefulness in relieving constipation (quality 1), usefulness for general physical health (quality 2), difficulty in following, activity intensity, fun, and overall quality. Raters were asked open-ended questions to evaluate the strengths and weaknesses of the videos. Read More

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http://dx.doi.org/10.4166/kjg.2018.72.6.295DOI Listing
December 2018
1 Read

Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning.

J Physiol 2019 Mar 27;597(6):1517-1529. Epub 2019 Feb 27.

Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.

Key Points: Nausea is an adverse experience characterised by alterations in autonomic and cerebral function. Susceptibility to nausea is difficult to predict, but machine learning has yet to be applied to this field of study. The severity of nausea that individuals experience is related to the underlying morphology (shape) of the subcortex, namely of the amygdala, caudate and putamen; a functional brain network related to nausea severity was identified, which included the thalamus, cingulate cortices (anterior, mid- and posterior), caudate nucleus and nucleus accumbens. Read More

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http://doi.wiley.com/10.1113/JP277474
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http://dx.doi.org/10.1113/JP277474DOI Listing
March 2019
7 Reads
5.037 Impact Factor

Availability of over-the-counter laxatives should not be restricted.

Authors:
Peter J Whorwell

BMJ 2019 Jan 9;364:l51. Epub 2019 Jan 9.

Neurogastroenterology Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1136/bmj.l51DOI Listing
January 2019

The IASP classification of chronic pain for ICD-11: chronic secondary visceral pain.

Pain 2019 Jan;160(1):69-76

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

Chronic visceral pain is a frequent and disabling condition. Despite high prevalence and impact, chronic visceral pain is not represented in ICD-10 in a systematic manner. Chronic secondary visceral pain is chronic pain secondary to an underlying condition originating from internal organs of the head or neck region or of the thoracic, abdominal, or pelvic regions. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001362DOI Listing
January 2019
5 Reads
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
14 Reads
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic primary pain.

Pain 2019 Jan;160(1):28-37

Department of Neurophysiology, CBTM, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

This article describes a proposal for the new diagnosis of chronic primary pain (CPP) in ICD-11. Chronic primary pain is chosen when pain has persisted for more than 3 months and is associated with significant emotional distress and/or functional disability, and the pain is not better accounted for by another condition. As with all pain, the article assumes a biopsychosocial framework for understanding CPP, which means all subtypes of the diagnosis are considered to be multifactorial in nature, with biological, psychological, and social factors contributing to each. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001390DOI Listing
January 2019
1 Read
5.213 Impact Factor

Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11).

Pain 2019 Jan;160(1):19-27

The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Chronic pain is a major source of suffering. It interferes with daily functioning and often is accompanied by distress. Yet, in the International Classification of Diseases, chronic pain diagnoses are not represented systematically. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001384DOI Listing
January 2019
4 Reads
5.213 Impact Factor

Pseudocholinesterase Deficiency: What the Proceduralist Needs to Know.

Am J Med Sci 2019 Mar 10;357(3):263-267. Epub 2018 Nov 10.

Department of Internal Medicine and; Center for Neurogastroenterology and GI Motility, Texas Tech University Health Science Center - Paul L. Foster School of Medicine, El Paso, Texas. Electronic address:

Pseudocholinesterase deficiency is a rare genetic as well as an acquired disorder that affects the body's ability to metabolize choline esters such as succinylcholine and mivacurium. It can be inherited as an autosomal recessive trait, occurring in approximately 1 in 3,200 to 1 in 5,000 people. In most cases of pseudocholinesterase deficiency, no signs or symptoms of the condition exist. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029629183041
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http://dx.doi.org/10.1016/j.amjms.2018.11.002DOI Listing
March 2019
15 Reads

Current perspectives on the diagnosis and management of functional anorectal disorders in patients with inflammatory bowel disease.

Therap Adv Gastroenterol 2018 6;11:1756284818816956. Epub 2018 Dec 6.

Honorary Senior Lecturer, Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester University NHS Foundation Trust, Neurogastroenterology Unit, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK.

Despite advances in inflammatory bowel disease (IBD) therapies, a significant proportion of patients with quiescent disease experience persistent, debilitating symptoms of faecal incontinence (FI), urgency and defaecatory disorders due to anorectal dysfunction. Such symptoms are often underreported or misdiagnosed and can lead to potentially premature treatment 'escalation' and under-utilisation of pelvic floor investigations. In this review article, we consider putative pathophysiological post-inflammatory changes resulting in altered anorectal sensitivity, motility and neuromuscular coordination and how this may drive symptoms in quiescent IBD. Read More

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http://dx.doi.org/10.1177/1756284818816956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295686PMC
December 2018
2 Reads

The content validity of the ANMS GCSI-DD in patients with idiopathic or diabetic gastroparesis.

J Patient Rep Outcomes 2018 Dec 13;2(1):61. Epub 2018 Dec 13.

Temple University Hospital, 3401 N Broad Street, #1003, Philadelphia, PA, 19140, USA.

Background: The American Neurogastroenterology and Motility Society Gastroparesis Cardinal Symptom Index-Daily Diary (ANMS GCSI-DD) was developed to meet Food and Drug Administration (FDA) recommendations for patient-reported outcome (PRO) endpoints in gastroparesis studies, including therapeutic trials. The current version of the ANMS GCSI-DD contains five items pertaining to nausea, early satiety, post-prandial fullness, upper abdominal pain, and vomiting. The specific aims of this study were to determine if the appropriate symptoms are included in the ANMS GCSI-DD and to assess the content validity in patients with idiopathic (IG) and diabetic gastroparesis (DG). Read More

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https://jpro.springeropen.com/articles/10.1186/s41687-018-00
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http://dx.doi.org/10.1186/s41687-018-0081-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292831PMC
December 2018
16 Reads

FOXO3 Loss Drives Inflammation-Associated CRC: The Consequences of Being (Knock)Out-FOX'd.

Cell Mol Gastroenterol Hepatol 2019 4;7(2):295-296. Epub 2018 Dec 4.

Priority Research Centre for Digestive Health and Neurogastroenterology, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357886PMC

Effect of transcutaneous vagus nerve stimulation on muscle activity in the gastrointestinal tract (transVaGa): a prospective clinical trial.

Int J Colorectal Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, University Hospital of Bonn, Bonn, Germany.

Purpose: Postoperative ileus (POI) is a common complication after abdominal surgery. Invasive stimulation of the cervical vagus nerve is known to reduce inflammatory response and ameliorated POI after surgery in a mouse model. However, the transcutaneous vagus nerve stimulation (tVNS) is a possible non-invasive approach. Read More

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http://link.springer.com/10.1007/s00384-018-3204-6
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http://dx.doi.org/10.1007/s00384-018-3204-6DOI Listing
December 2018
22 Reads

Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis.

Mol Aspects Med 2018 Dec 12. Epub 2018 Dec 12.

Research Unit of Translational Neurogastroenterology, Division of Pharmacology, Otto Loewi Research Centre, Medical University of Graz, Universitätsplatz 4, A-8010 Graz, Austria; BioTechMed-Graz, Mozartgasse 12, A-8010 Graz, Austria. Electronic address:

The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patients with type 2 diabetes, depressed patients are also more prone to develop diabetes. This reciprocal relationship calls for a molecular and systemic analysis of diabesity-brain interactions to guide preventive and therapeutic strategies. Read More

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http://dx.doi.org/10.1016/j.mam.2018.11.003DOI Listing
December 2018
20 Reads

Neuroprotective effects of vitamin D on high fat diet- and palmitic acid-induced enteric neuronal loss in mice.

BMC Gastroenterol 2018 Nov 21;18(1):175. Epub 2018 Nov 21.

Unit of Neurogastroenterology, Department of Experimental Medical Science, Lund University, Sölvegatan 19, BMC B11, 22184, Lund, Sweden.

Background: The role of vitamin D in obesity and diabetes is debated. Obese and/or diabetic patients have elevated levels of free fatty acids, increased susceptibility to gastrointestinal symptoms and are suggested to have altered vitamin D balance. The enteric nervous system is pivotal in regulating gastrointestinal activity and high fat diet (HFD) has been shown to cause loss of enteric neurons in ileum and colon. Read More

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http://dx.doi.org/10.1186/s12876-018-0905-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249721PMC
November 2018
10 Reads

Probiotics in irritable bowel syndrome: Where are we?

Neurogastroenterol Motil 2018 Dec;30(12):e13513

Digestive System Research Unit, Departments of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Departamento de Medicina) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

We have only recently begun to understand how alterations of the intestinal microbial ecosystem lead to the disruption of host-microbial interactions and are associated with diseases, including functional gastrointestinal disorders such as irritable bowel syndrome (IBS). Although we are still far from understanding the human microbiome, gut microbiota is already a therapeutic target. Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit to the host and may represent a therapeutic option for diseases characterized by dysbiosis such as IBS. Read More

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http://dx.doi.org/10.1111/nmo.13513DOI Listing
December 2018
16 Reads
3.587 Impact Factor

Probiotics can Cause D-Lactic Acidosis and Brain Fogginess: Reply to Quigley et al.

Clin Transl Gastroenterol 2018 Nov 19;9(11):207. Epub 2018 Nov 19.

Division of Neurogastroenterology/Motility, Department of Medicine, Augusta University Medical Center, Augusta, GA, USA.

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http://dx.doi.org/10.1038/s41424-018-0077-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240559PMC
November 2018
2 Reads

Evidence for Local and Systemic Immune Activation in Functional Dyspepsia and the Irritable Bowel Syndrome: A Systematic Review.

Am J Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

School of Biomedical Sciences & Pharmacy, Faculty of Health & Medicine, University of Newcastle, Newcastle, NSW, Australia.

Background: Subtle histopathologic features such as eosinophilia and increased mast cells have been observed in functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD) and the irritable bowel syndrome (IBS). The mechanisms that drive recruitment of these cells to the gastrointestinal tract remain unexplained, largely due to the heterogeneity in phenotypes among patients diagnosed with such conditions. We aimed to systematically review the literature and collate the evidence for immune activation in FD and IBS, and where possible, detail the nature of activation. Read More

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http://www.nature.com/articles/s41395-018-0377-0
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http://dx.doi.org/10.1038/s41395-018-0377-0DOI Listing
November 2018
15 Reads

Cow's Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

Nutrients 2018 Nov 9;10(11). Epub 2018 Nov 9.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Holtz Children's Hospital, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.

The role and prevalence of cow's milk protein allergy (CMA) in functional gastrointestinal disorders remains unclear. The aim of this review is to update knowledge on the relationship between CMA and functional abdominal pain disorders (FAPDs) in children. Cochrane Database and Pubmed were searched from inception using general and specific terms for CMA and functional gastrointestinal disorders. Read More

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http://dx.doi.org/10.3390/nu10111716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265683PMC
November 2018
10 Reads

[Interpretation und performance of high-resolution esophageal manometry: Recommendations of the German Association of Neurogastroenterology and Motility (DGNM) and the German Association of Gastroenterology, Digestive and Metabolic Diseases (DGVS)].

Z Gastroenterol 2018 Nov 12;56(11):1378-1408. Epub 2018 Nov 12.

Medizinische Klinik und Poliklinik II, LMU, Campus Großhadern, München.

Esophageal manometry provides a detailed evaluation of esophageal contractility and, therefore, represents the reference method for diagnosis of esophageal motility disorders. Significance and clinical relevance have been further increased by implementation of high-resolution esophageal manometry (HRM), which reveals the functional anatomy of the esophagus in a visually-intuitive manner. The current 3 rd version of the international Chicago Classification (CC v3. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0713-0944
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http://dx.doi.org/10.1055/a-0713-0944DOI Listing
November 2018
3 Reads

Isolation and characterisation of mouse intestinal mesoangioblasts.

Pediatr Surg Int 2019 Jan 8;35(1):29-34. Epub 2018 Nov 8.

Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

Aims And Objectives: Children suffering from intestinal failure (IF) endure considerable morbidity and overall have poor survival rates, complicated by the shortage of organs available for transplantation. Therefore, new therapeutic approaches are pivotal if outcomes are to be improved. Over the past years, tissue engineering (TE) has emerged as a possible alternative treatment for many congenital and acquired conditions. Read More

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http://link.springer.com/10.1007/s00383-018-4373-7
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http://dx.doi.org/10.1007/s00383-018-4373-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325996PMC
January 2019
12 Reads

Epidemiology and Pathophysiology of Gastroparesis.

Gastrointest Endosc Clin N Am 2019 Jan;29(1):1-14

Global Research, Digestive and Health Neurogastroenterology, New Lambton, NSW 2305, Australia.

Gastroparesis is a complex syndrome with symptoms that include nausea, vomiting, and postprandial abdominal pain, and is frequently accompanied by significant delays in gastric emptying. The pathophysiology of diabetic gastroparesis is fairly well understood; however, idiopathic gastroparesis, which accounts for one-third of all cases, may stem from infections, or autoimmune or neurologic disorders, among other causes. To date, few population-based studies have estimated the true prevalence and incidence of gastroparesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10525157183079
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http://dx.doi.org/10.1016/j.giec.2018.08.010DOI Listing
January 2019
11 Reads

Development of a real-time patient-reported outcome measure for symptom assessment in patients with functional dyspepsia using the experience sampling method.

Neurogastroenterol Motil 2019 Feb 4;31(2):e13496. Epub 2018 Nov 4.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

Background: Patient-reported outcome measures (PROMs) are used to assess symptoms in patients with functional dyspepsia (FD). Current end-of-day questionnaires have several limitations including sensitivity to recall and ecological bias. The experience sampling method (ESM) is characterized by random and repeated assessments across momentary states in daily life and therefore less sensitive to these limitations. Read More

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http://doi.wiley.com/10.1111/nmo.13496
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http://dx.doi.org/10.1111/nmo.13496DOI Listing
February 2019
5 Reads
3.590 Impact Factor

Complementary and Alternative Medicine for the Management of Irritable Bowel Syndrome.

Authors:
Linda Nguyen

Gastroenterol Hepatol (N Y) 2018 Sep;14(9):536-538

Clinical Associate Professor Clinic Director, Digestive Health Center Director, Neurogastroenterology & Motility Stanford University Stanford, California.

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https://www.researchgate.net/publication/51198816_Management
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http://www.gastroenterologyandhepatology.net/archives/septem
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https://www.amjmed.com/article/S0002-9343(15)00168-0/pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194653PMC
September 2018
29 Reads

Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation.

Neurogastroenterol Motil 2019 Feb 23;31(2):e13492. Epub 2018 Oct 23.

The Functional Gut Clinic, London, UK.

Background: Linaclotide is efficacious in the management of irritable bowel syndrome with constipation (IBS-C), yet relatively little is known regarding its effect on human gastrointestinal physiology. The primary aim of the study was to examine the effect of linaclotide on change in pH across the ileocecal junction (ICJ), a proposed measure of cecal fermentation, and its relationship to symptoms and quality of life (QoL) in IBS-C.

Methods: A total of 13 participants with Rome III IBS-C underwent a standardized wireless motility capsule (WMC). Read More

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http://doi.wiley.com/10.1111/nmo.13492
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http://dx.doi.org/10.1111/nmo.13492DOI Listing
February 2019
12 Reads

Stem cell therapy in severe pediatric motility disorders.

Curr Opin Pharmacol 2018 Dec 16;43:145-149. Epub 2018 Oct 16.

Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK; Neurogastroenterology and Motility Unit, Department of Paediatric Gastroenterology, Great Ormond Street Hospital NHS Foundation Trust, London, WC1N 3JH, UK. Electronic address:

Pediatric gastrointestinal motility disorders represent a range of severe developmental or acquired conditions that disrupt enteric neuromuscular function. Current medical and surgical therapeutic options are very limited but recent advances have highlighted the possibility of improved or curative stem cell-based treatments. Not only has the ability to harvest, propagate and transplant human-derived enteric neural stem cells (ENSCs) been demonstrated but recent in vivo transplantation studies have confirmed that ENSCs are capable of engraftment within recipient intestine of animal models of enteric neuropathy and effecting functional rescue. Read More

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http://dx.doi.org/10.1016/j.coph.2018.09.004DOI Listing
December 2018
2 Reads

Gastrointestinal Neuropathies: New Insights and Emerging Therapies.

Gastroenterol Clin North Am 2018 12 28;47(4):877-894. Epub 2018 Sep 28.

Neurogastroenterology and Motility Unit, Department of Pediatric Gastroenterology, Great Ormond Street Hospital, London WC1N 3JH, UK; Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

The bewildering complexity of the enteric nervous system makes it susceptible to develop a wide array of motility disorders, collectively called enteric neuropathies. These gastrointestinal conditions are among the most challenging to manage, mainly given poor characterization of their etiopathophysiology and outcomes. Not surprisingly, therefore, targeted or curative therapies for enteric neuropathies are lacking and management is largely symptomatic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898553183006
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http://dx.doi.org/10.1016/j.gtc.2018.07.011DOI Listing
December 2018
29 Reads

Moving Neurogastroenterology and Motility into the social media age.

Neurogastroenterol Motil 2018 Nov;30(11):e13455

Editorial Office, Neurogastroenterology and Motility, Minehead, UK.

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http://dx.doi.org/10.1111/nmo.13455DOI Listing
November 2018
15 Reads

Cap-assisted endoscopy: Do we have enough evidence?

Authors:
Thomas Frieling

Endosc Int Open 2018 Oct 8;6(10):E1224-E1226. Epub 2018 Oct 8.

Department of Gastroenterology, Hepatology, Infectiology, Neurogastroenterology, Hematology, Oncology, and Palliative Medicine, HELIOS-Clinic Krefeld, Krefeld, Germany.

So, is there enough evidence to incorporate CC in clinical practice? If we interpret the literature and the meta-analysis by Nutalapati et al., the answer for the clinically-focused endoscopist, with regard to adenoma detection rate (ADR), at present, may be "no". Significant differences do not necessarily imply clinical benefits and translation into clinical practice. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0650-4544
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http://dx.doi.org/10.1055/a-0650-4544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187477PMC
October 2018
11 Reads

Artificial Intelligence-Assisted Gastroenterology- Promises and Pitfalls.

Am J Gastroenterol 2019 Mar;114(3):422-428

Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.

Technological advances in artificial intelligence (AI) represent an enticing opportunity to benefit gastroenterological practice. Moreover, AI, through machine or deep learning, permits the ability to develop predictive models from large datasets. Possibilities of predictive model development in machine learning are numerous dependent on the clinical question. Read More

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http://dx.doi.org/10.1038/s41395-018-0268-4DOI Listing
March 2019
15 Reads
10.760 Impact Factor

Diabetic gastroparesis: current challenges and future prospects.

Clin Exp Gastroenterol 2018 25;11:347-363. Epub 2018 Sep 25.

Division of Gastroenterology, Center for Neurogastroenterology and GI Motility, Texas Tech University Health Sciences Center, El Paso, TX, USA,

Diabetic gastroparesis (DMGP) is a condition of delayed gastric emptying after gastric outlet obstruction has been excluded. Symptoms of nausea, vomiting, early satiety, bloating, and abdominal pain are associated with DMGP. Uncontrolled symptoms can lead to overall poor quality of life and financial burdens on the healthcare system. Read More

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https://www.dovepress.com/diabetic-gastroparesis-current-cha
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http://dx.doi.org/10.2147/CEG.S131650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165730PMC
September 2018
4 Reads

Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment.

J Diabetes Res 2018 16;2018:3827301. Epub 2018 Sep 16.

Mech-Sense, Department of Clinical Medicine, Aalborg University, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark.

The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. Read More

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http://dx.doi.org/10.1155/2018/3827301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165592PMC
December 2018

Non-celiac gluten/wheat sensitivity (NCGS)-a currently undefined disorder without validated diagnostic criteria and of unknown prevalence: Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunology (DGAKI).

Allergo J Int 2018 28;27(5):147-151. Epub 2018 May 28.

10Department of Dermatology, Venereology and Allergology, Allergy Center Charité (ACC), Charité University Hospital, Berlin, Germany.

Within the last decade, non-celiac gluten/wheat sensitivity (NCGS) has been increasingly discussed not only in the media but also among medical specialties. The existence and the possible triggers of NCGS are controversial. Three international expert meetings which proposed recommendations for NCGS were not independently organized and only partially transparent regarding potential conflicts of interest of the participants. Read More

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http://link.springer.com/10.1007/s40629-018-0070-2
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http://dx.doi.org/10.1007/s40629-018-0070-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153714PMC
May 2018
99 Reads

Preservation of the colo-anal reflex in colonic transection and post-operative Hirschsprung's disease: Potential extrinsic neural pathway.

Neurogastroenterol Motil 2019 Jan 4;31(1):e13472. Epub 2018 Oct 4.

Division of Neurogastroenterology and Motility, Department of Paediatric Gastroenterology, Great Ormond Street Hospital, NHS Foundation Trust, London, UK.

Background: The colo-anal reflex is a distinct reflex whereby the internal anal sphincter (IAS) relaxes in association with colonic high amplitude propagating contractions (HAPCs) in contrast to the recto-anal inhibitory reflex (RAIR), which is characterized by IAS relaxation upon rectal distension. The RAIR is mediated by the myenteric plexus and therefore absent in Hirschsprung disease. We retrospectively assessed the presence and the characteristics of the colo-anal reflex in children in whom large bowel continuity had been surgically disrupted to assess the role of the extrinsic nervous system in the reflex. Read More

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http://dx.doi.org/10.1111/nmo.13472DOI Listing
January 2019
19 Reads

Post-infectious IBS: Defining its clinical features and prognosis using an internet-based survey.

United European Gastroenterol J 2018 Oct 23;6(8):1245-1253. Epub 2018 May 23.

Nottingham Digestive Diseases Centre, University of Nottingham and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.

Background: Gastrointestinal infection is an important risk factor for developing irritable bowel syndrome (IBS). Our aim was to characterise post-infectious IBS (PI-IBS) compared to other IBS patients.

Methods: An internet survey of IBS patients using Rome III diagnostic questionnaire, Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-12 Somatic Symptom (PHQ12-SS) scale score documenting the mode of onset was conducted. Read More

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http://dx.doi.org/10.1177/2050640618779923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169057PMC
October 2018
18 Reads

Pharmacological Treatment of Opioid-Induced Constipation Is Effective but Choice of Endpoints Affects the Therapeutic Gain.

Dig Dis Sci 2019 01 3;64(1):39-49. Epub 2018 Oct 3.

Section of Gastroenterology, George E. Wahlen VAMC, 500 Foothill Dr, Salt Lake City, UT, 84103, USA.

Background: Widespread opioid use has led to increase in opioid-related adverse effects like constipation. We examined the impact of study endpoints on reported treatment benefits.

Methods: Using MEDLINE, EMBASE, and ClinicalTrials. Read More

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http://dx.doi.org/10.1007/s10620-018-5308-9DOI Listing
January 2019
3 Reads

Autoimmune autonomic ganglionopathy associated with Sjögren's syndrome presenting with recurrent abdominal distension.

BMJ Case Rep 2018 Oct 2;2018. Epub 2018 Oct 2.

Molecular Neurology and Therapeutics, Kumamoto University Hospital, Kumamoto, Japan.

A 65-year-old woman with Sjögren's syndrome presented with recurrent abdominal distension, constipation, weight loss, orthostatic dizziness, loss of sweating and incomplete emptying of the bladder. Gastrointestinal dilatation but no evidence of malignancy or obstruction was found on CT of the abdomen, oesophagogastroduodenoscopy or colonoscopy. Postvoiding residual urine volume was increased. Read More

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http://dx.doi.org/10.1136/bcr-2017-223785DOI Listing
October 2018
4 Reads