907 results match your criteria Neurogastroenterology & Motility[Journal]


FOXO3 Loss Drives Inflammation-Associated CRC: The Consequences of Being (Knock)Out-FOX'd.

Cell Mol Gastroenterol Hepatol 2018 Dec 4. Epub 2018 Dec 4.

Priority Research Centre for Digestive Health and Neurogastroenterology, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia. Electronic address:

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December 2018

Effect of transcutaneous vagus nerve stimulation on muscle activity in the gastrointestinal tract (transVaGa): a prospective clinical trial.

Int J Colorectal Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, University Hospital of Bonn, Bonn, Germany.

Purpose: Postoperative ileus (POI) is a common complication after abdominal surgery. Invasive stimulation of the cervical vagus nerve is known to reduce inflammatory response and ameliorated POI after surgery in a mouse model. However, the transcutaneous vagus nerve stimulation (tVNS) is a possible non-invasive approach. Read More

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December 2018
5 Reads

Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis.

Mol Aspects Med 2018 Dec 7. Epub 2018 Dec 7.

Research Unit of Translational Neurogastroenterology, Division of Pharmacology, Otto Loewi Research Centre, Medical University of Graz, Universitätsplatz 4, A-8010 Graz, Austria; BioTechMed-Graz, Mozartgasse 12, A-8010 Graz, Austria. Electronic address:

The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patients with type 2 diabetes, depressed patients are also more prone to develop diabetes. This reciprocal relationship calls for a molecular and systemic analysis of diabesity-brain interactions to guide preventive and therapeutic strategies. Read More

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December 2018
4 Reads

Neuroprotective effects of vitamin D on high fat diet- and palmitic acid-induced enteric neuronal loss in mice.

BMC Gastroenterol 2018 Nov 21;18(1):175. Epub 2018 Nov 21.

Unit of Neurogastroenterology, Department of Experimental Medical Science, Lund University, Sölvegatan 19, BMC B11, 22184, Lund, Sweden.

Background: The role of vitamin D in obesity and diabetes is debated. Obese and/or diabetic patients have elevated levels of free fatty acids, increased susceptibility to gastrointestinal symptoms and are suggested to have altered vitamin D balance. The enteric nervous system is pivotal in regulating gastrointestinal activity and high fat diet (HFD) has been shown to cause loss of enteric neurons in ileum and colon. Read More

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November 2018
1 Read

Probiotics in irritable bowel syndrome: Where are we?

Neurogastroenterol Motil 2018 Dec;30(12):e13513

Digestive System Research Unit, Departments of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Departamento de Medicina) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

We have only recently begun to understand how alterations of the intestinal microbial ecosystem lead to the disruption of host-microbial interactions and are associated with diseases, including functional gastrointestinal disorders such as irritable bowel syndrome (IBS). Although we are still far from understanding the human microbiome, gut microbiota is already a therapeutic target. Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit to the host and may represent a therapeutic option for diseases characterized by dysbiosis such as IBS. Read More

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December 2018
6 Reads

Probiotics can Cause D-Lactic Acidosis and Brain Fogginess: Reply to Quigley et al.

Clin Transl Gastroenterol 2018 Nov 19;9(11):207. Epub 2018 Nov 19.

Division of Neurogastroenterology/Motility, Department of Medicine, Augusta University Medical Center, Augusta, GA, USA.

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November 2018
1 Read

Evidence for Local and Systemic Immune Activation in Functional Dyspepsia and the Irritable Bowel Syndrome: A Systematic Review.

Am J Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

School of Biomedical Sciences & Pharmacy, Faculty of Health & Medicine, University of Newcastle, Newcastle, NSW, Australia.

Background: Subtle histopathologic features such as eosinophilia and increased mast cells have been observed in functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD) and the irritable bowel syndrome (IBS). The mechanisms that drive recruitment of these cells to the gastrointestinal tract remain unexplained, largely due to the heterogeneity in phenotypes among patients diagnosed with such conditions. We aimed to systematically review the literature and collate the evidence for immune activation in FD and IBS, and where possible, detail the nature of activation. Read More

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November 2018
9 Reads

Cow's Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

Nutrients 2018 Nov 9;10(11). Epub 2018 Nov 9.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Holtz Children's Hospital, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.

The role and prevalence of cow's milk protein allergy (CMA) in functional gastrointestinal disorders remains unclear. The aim of this review is to update knowledge on the relationship between CMA and functional abdominal pain disorders (FAPDs) in children. Cochrane Database and Pubmed were searched from inception using general and specific terms for CMA and functional gastrointestinal disorders. Read More

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November 2018
3 Reads

[Interpretation und performance of high-resolution esophageal manometry: Recommendations of the German Association of Neurogastroenterology and Motility (DGNM) and the German Association of Gastroenterology, Digestive and Metabolic Diseases (DGVS)].

Z Gastroenterol 2018 Nov 12;56(11):1378-1408. Epub 2018 Nov 12.

Medizinische Klinik und Poliklinik II, LMU, Campus Großhadern, München.

Esophageal manometry provides a detailed evaluation of esophageal contractility and, therefore, represents the reference method for diagnosis of esophageal motility disorders. Significance and clinical relevance have been further increased by implementation of high-resolution esophageal manometry (HRM), which reveals the functional anatomy of the esophagus in a visually-intuitive manner. The current 3 rd version of the international Chicago Classification (CC v3. Read More

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November 2018
2 Reads

Isolation and characterisation of mouse intestinal mesoangioblasts.

Pediatr Surg Int 2018 Nov 8. Epub 2018 Nov 8.

Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

Aims And Objectives: Children suffering from intestinal failure (IF) endure considerable morbidity and overall have poor survival rates, complicated by the shortage of organs available for transplantation. Therefore, new therapeutic approaches are pivotal if outcomes are to be improved. Over the past years, tissue engineering (TE) has emerged as a possible alternative treatment for many congenital and acquired conditions. Read More

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November 2018
4 Reads

Epidemiology and Pathophysiology of Gastroparesis.

Gastrointest Endosc Clin N Am 2019 Jan;29(1):1-14

Global Research, Digestive and Health Neurogastroenterology, New Lambton, NSW 2305, Australia.

Gastroparesis is a complex syndrome with symptoms that include nausea, vomiting, and postprandial abdominal pain, and is frequently accompanied by significant delays in gastric emptying. The pathophysiology of diabetic gastroparesis is fairly well understood; however, idiopathic gastroparesis, which accounts for one-third of all cases, may stem from infections, or autoimmune or neurologic disorders, among other causes. To date, few population-based studies have estimated the true prevalence and incidence of gastroparesis. Read More

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January 2019
2 Reads

Development of a real-time patient-reported outcome measure for symptom assessment in patients with functional dyspepsia using the experience sampling method.

Neurogastroenterol Motil 2018 Nov 4:e13496. Epub 2018 Nov 4.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

Background: Patient-reported outcome measures (PROMs) are used to assess symptoms in patients with functional dyspepsia (FD). Current end-of-day questionnaires have several limitations including sensitivity to recall and ecological bias. The experience sampling method (ESM) is characterized by random and repeated assessments across momentary states in daily life and therefore less sensitive to these limitations. Read More

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November 2018
3 Reads
3.590 Impact Factor

Complementary and Alternative Medicine for the Management of Irritable Bowel Syndrome.

Authors:
Linda Nguyen

Gastroenterol Hepatol (N Y) 2018 Sep;14(9):536-538

Clinical Associate Professor Clinic Director, Digestive Health Center Director, Neurogastroenterology & Motility Stanford University Stanford, California.

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September 2018
6 Reads

Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation.

Neurogastroenterol Motil 2018 Oct 23:e13492. Epub 2018 Oct 23.

The Functional Gut Clinic, London, UK.

Background: Linaclotide is efficacious in the management of irritable bowel syndrome with constipation (IBS-C), yet relatively little is known regarding its effect on human gastrointestinal physiology. The primary aim of the study was to examine the effect of linaclotide on change in pH across the ileocecal junction (ICJ), a proposed measure of cecal fermentation, and its relationship to symptoms and quality of life (QoL) in IBS-C.

Methods: A total of 13 participants with Rome III IBS-C underwent a standardized wireless motility capsule (WMC). Read More

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October 2018
7 Reads

Stem cell therapy in severe pediatric motility disorders.

Curr Opin Pharmacol 2018 Oct 16;43:145-149. Epub 2018 Oct 16.

Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK; Neurogastroenterology and Motility Unit, Department of Paediatric Gastroenterology, Great Ormond Street Hospital NHS Foundation Trust, London, WC1N 3JH, UK. Electronic address:

Pediatric gastrointestinal motility disorders represent a range of severe developmental or acquired conditions that disrupt enteric neuromuscular function. Current medical and surgical therapeutic options are very limited but recent advances have highlighted the possibility of improved or curative stem cell-based treatments. Not only has the ability to harvest, propagate and transplant human-derived enteric neural stem cells (ENSCs) been demonstrated but recent in vivo transplantation studies have confirmed that ENSCs are capable of engraftment within recipient intestine of animal models of enteric neuropathy and effecting functional rescue. Read More

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October 2018
1 Read

Gastrointestinal Neuropathies: New Insights and Emerging Therapies.

Gastroenterol Clin North Am 2018 12 28;47(4):877-894. Epub 2018 Sep 28.

Neurogastroenterology and Motility Unit, Department of Pediatric Gastroenterology, Great Ormond Street Hospital, London WC1N 3JH, UK; Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

The bewildering complexity of the enteric nervous system makes it susceptible to develop a wide array of motility disorders, collectively called enteric neuropathies. These gastrointestinal conditions are among the most challenging to manage, mainly given poor characterization of their etiopathophysiology and outcomes. Not surprisingly, therefore, targeted or curative therapies for enteric neuropathies are lacking and management is largely symptomatic. Read More

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December 2018
11 Reads

Moving Neurogastroenterology and Motility into the social media age.

Neurogastroenterol Motil 2018 Nov;30(11):e13455

Editorial Office, Neurogastroenterology and Motility, Minehead, UK.

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November 2018
8 Reads

Cap-assisted endoscopy: Do we have enough evidence?

Authors:
Thomas Frieling

Endosc Int Open 2018 Oct 8;6(10):E1224-E1226. Epub 2018 Oct 8.

Department of Gastroenterology, Hepatology, Infectiology, Neurogastroenterology, Hematology, Oncology, and Palliative Medicine, HELIOS-Clinic Krefeld, Krefeld, Germany.

So, is there enough evidence to incorporate CC in clinical practice? If we interpret the literature and the meta-analysis by Nutalapati et al., the answer for the clinically-focused endoscopist, with regard to adenoma detection rate (ADR), at present, may be "no". Significant differences do not necessarily imply clinical benefits and translation into clinical practice. Read More

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October 2018
5 Reads

Artificial Intelligence-Assisted Gastroenterology-Promises and Pitfalls.

Am J Gastroenterol 2018 Oct 12. Epub 2018 Oct 12.

Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.

Technological advances in artificial intelligence (AI) represent an enticing opportunity to benefit gastroenterological practice. Moreover, AI, through machine or deep learning, permits the ability to develop predictive models from large datasets. Possibilities of predictive model development in machine learning are numerous dependent on the clinical question. Read More

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October 2018
1 Read
10.760 Impact Factor

Diabetic gastroparesis: current challenges and future prospects.

Clin Exp Gastroenterol 2018 25;11:347-363. Epub 2018 Sep 25.

Division of Gastroenterology, Center for Neurogastroenterology and GI Motility, Texas Tech University Health Sciences Center, El Paso, TX, USA,

Diabetic gastroparesis (DMGP) is a condition of delayed gastric emptying after gastric outlet obstruction has been excluded. Symptoms of nausea, vomiting, early satiety, bloating, and abdominal pain are associated with DMGP. Uncontrolled symptoms can lead to overall poor quality of life and financial burdens on the healthcare system. Read More

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September 2018
2 Reads

Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment.

J Diabetes Res 2018 16;2018:3827301. Epub 2018 Sep 16.

Mech-Sense, Department of Clinical Medicine, Aalborg University, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark.

The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. Read More

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December 2018

Non-celiac gluten/wheat sensitivity (NCGS)-a currently undefined disorder without validated diagnostic criteria and of unknown prevalence: Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunology (DGAKI).

Allergo J Int 2018 28;27(5):147-151. Epub 2018 May 28.

10Department of Dermatology, Venereology and Allergology, Allergy Center Charité (ACC), Charité University Hospital, Berlin, Germany.

Within the last decade, non-celiac gluten/wheat sensitivity (NCGS) has been increasingly discussed not only in the media but also among medical specialties. The existence and the possible triggers of NCGS are controversial. Three international expert meetings which proposed recommendations for NCGS were not independently organized and only partially transparent regarding potential conflicts of interest of the participants. Read More

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May 2018
2 Reads

Preservation of the colo-anal reflex in colonic transection and post-operative Hirschsprung's disease: Potential extrinsic neural pathway.

Neurogastroenterol Motil 2018 Oct 4:e13472. Epub 2018 Oct 4.

Division of Neurogastroenterology and Motility, Department of Paediatric Gastroenterology, Great Ormond Street Hospital, NHS Foundation Trust, London, UK.

Background: The colo-anal reflex is a distinct reflex whereby the internal anal sphincter (IAS) relaxes in association with colonic high amplitude propagating contractions (HAPCs) in contrast to the recto-anal inhibitory reflex (RAIR), which is characterized by IAS relaxation upon rectal distension. The RAIR is mediated by the myenteric plexus and therefore absent in Hirschsprung disease. We retrospectively assessed the presence and the characteristics of the colo-anal reflex in children in whom large bowel continuity had been surgically disrupted to assess the role of the extrinsic nervous system in the reflex. Read More

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October 2018
13 Reads

Post-infectious IBS: Defining its clinical features and prognosis using an internet-based survey.

United European Gastroenterol J 2018 Oct 23;6(8):1245-1253. Epub 2018 May 23.

Nottingham Digestive Diseases Centre, University of Nottingham and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.

Background: Gastrointestinal infection is an important risk factor for developing irritable bowel syndrome (IBS). Our aim was to characterise post-infectious IBS (PI-IBS) compared to other IBS patients.

Methods: An internet survey of IBS patients using Rome III diagnostic questionnaire, Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-12 Somatic Symptom (PHQ12-SS) scale score documenting the mode of onset was conducted. Read More

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October 2018
7 Reads

Pharmacological Treatment of Opioid-Induced Constipation Is Effective but Choice of Endpoints Affects the Therapeutic Gain.

Dig Dis Sci 2018 Oct 3. Epub 2018 Oct 3.

Section of Gastroenterology, George E. Wahlen VAMC, 500 Foothill Dr, Salt Lake City, UT, 84103, USA.

Background: Widespread opioid use has led to increase in opioid-related adverse effects like constipation. We examined the impact of study endpoints on reported treatment benefits.

Methods: Using MEDLINE, EMBASE, and ClinicalTrials. Read More

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October 2018
2 Reads

Autoimmune autonomic ganglionopathy associated with Sjögren's syndrome presenting with recurrent abdominal distension.

BMJ Case Rep 2018 Oct 2;2018. Epub 2018 Oct 2.

Molecular Neurology and Therapeutics, Kumamoto University Hospital, Kumamoto, Japan.

A 65-year-old woman with Sjögren's syndrome presented with recurrent abdominal distension, constipation, weight loss, orthostatic dizziness, loss of sweating and incomplete emptying of the bladder. Gastrointestinal dilatation but no evidence of malignancy or obstruction was found on CT of the abdomen, oesophagogastroduodenoscopy or colonoscopy. Postvoiding residual urine volume was increased. Read More

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October 2018
3 Reads

Needleless Transcutaneous Neuromodulation Accelerates Postoperative Recovery Mediated via Autonomic and Immuno-Cytokine Mechanisms in Patients With Cholecystolithiasis.

Neuromodulation 2018 Oct 1. Epub 2018 Oct 1.

Ningbo Pace Translational Medical Research Center, Ningbo, Zhejiang, China.

Background: Postsurgical gastrointestinal disturbance is clinically characterized by the delayed passage of flatus and stool, delayed resumption of oral feeding, dyspepsia symptoms, and postsurgical pain. This study was designed 1) to evaluate the effects of needleless transcutaneous neuromodulation (TN) on postoperative recovery; 2) to investigate mechanisms of the TN involving autonomic functions in postoperative patients after removal of the gallbladder.

Methods: Sixty patients scheduled for laparoscopic cholecystectomy (LC) were randomized to TN (n = 30) and sham-TN (n = 30). Read More

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October 2018
6 Reads
1.780 Impact Factor

Neurotrophic factors in enteric physiology and pathophysiology.

Authors:
Sumei Liu

Neurogastroenterol Motil 2018 Oct;30(10):e13446

Department of Biology, College of Science and Health, University of Wisconsin-La Crosse, La Crosse, Wisconsin.

Neurotrophic factors are traditionally recognized for their roles in differentiation, growth, and survival of specific neurons in the central and peripheral nervous system. Some neurotrophic factors are essential for the development and migration of the enteric nervous system along the fetal and post-natal gut. Over the last two decades, several non-developmental functions of neurotrophic factors have been characterized. Read More

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October 2018
1 Read

Monoamines in the enteric nervous system.

Histochem Cell Biol 2018 Dec 24;150(6):703-709. Epub 2018 Sep 24.

Institute of Anatomy, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstraße 9, 91054, Erlangen, Germany.

Recent advances in neurogastroenterology have extended and refined our knowledge on the roles monoamines play in physiology and pathophysiology of the gastrointestinal tract. The catecholamine noradrenaline, as the primary transmitter of postganglionic sympathetic neurons, orchestrates motility and secretory reflexes and controls arterial perfusion as well as immune functions. The catecholamine dopamine is produced by a subpopulation of enteric neurons which possibly use it as transmitter. Read More

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December 2018
6 Reads

Ameliorating effects and mechanisms of chronic electroacupuncture at ST36 in a rodent model of dyspepsia induced by cisplatin.

Neurogastroenterol Motil 2018 Sep 23:e13474. Epub 2018 Sep 23.

Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, Oklahoma.

Background: Chemotherapy-associated dyspepsia syndrome (CADS) is among the most intensive side effects and critical concerns for patients with cancer. To investigate the effects and mechanisms of chronic electroacupuncture (EA) at ST36 on chemotherapy-associated dyspeptic symptoms (CADS) in rats.

Methods: Cisplatin (8 mg/kg, ip) was given once to establish CADS model. Read More

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September 2018
1 Read

Abdominal pain presenting as a tight squeeze on a Tchaikovsky score.

Gastroenterology 2018 Sep 18. Epub 2018 Sep 18.

Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK. Electronic address:

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September 2018
1 Read
16.720 Impact Factor

Improved Imaging of Zebrafish Motility.

Authors:
Adam Rich

Neurogastroenterol Motil 2018 Sep;30(9):e13435

The College at Brockport, SUNY, Brockport, New York.

Zebrafish larvae are transparent and the entire gastrointestinal (GI) tract is easily visualized. Application of a new image analysis technique is reported in this issue of Neurogastroenterology and Motility (Neurogastroenterol Motil., 2018, volume 30, e13351). Read More

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September 2018

Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects.

Neurogastroenterol Motil 2018 Dec 14;30(12):e13463. Epub 2018 Sep 14.

NIHR Nottingham BRC, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.

Background: Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Nottingham test meal" (NTM) in healthy volunteers (HVs).

Methods: The NTM comprises (a) 400 mL liquid nutrient (0. Read More

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December 2018
5 Reads

Systematic review with meta-analysis: conditioned pain modulation in patients with the irritable bowel syndrome.

Aliment Pharmacol Ther 2018 Oct 11;48(8):797-806. Epub 2018 Sep 11.

Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.

Background: Irritable bowel syndrome (IBS) is common and is characterised by recurrent abdominal pain, which is a major contributor to healthcare seeking. The neurobiological basis of this pain is incompletely understood. Conditioned pain modulation is a neuromodulatory mechanism through which the brain inhibits the nociceptive afferent barrage through the descending pathways. Read More

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October 2018
3 Reads
5.730 Impact Factor

Mind the gut: probiotics in paediatric neurogastroenterology.

Benef Microbes 2018 Sep 10:1-16. Epub 2018 Sep 10.

6 KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.

The gut-brain axis has recently emerged as a key modulator of human health and the intestinal microbiome has a well-recognised pivotal role in this strong connection. The aim of this narrative review is to update and summarise the effect and clinical applicability of probiotics in paediatric neurogastroenterology. The Cochrane Database and PubMed were searched using keywords relating to different subtypes of functional gastrointestinal disorders (FGIDs) and their symptoms, those relating to the CNS and related neurological or behavioural dysfunction as well as 'probiotic' OR 'probiotics'. Read More

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September 2018
23 Reads

Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain.

Sci Rep 2018 Sep 7;8(1):13410. Epub 2018 Sep 7.

Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.

The mechanisms that underpin the anti-nociceptive effect of the parasympathetic nervous system (PNS) on visceral pain remain incompletely understood. We sought to describe the effect of resting parasympathetic tone on functional brain networks during the anticipation and experience of oesophageal pain. 21 healthy participants had their resting cardiac vagal tone (CVT), a validated measure of the PNS, quantified, and underwent functional magnetic resonance imaging during the anticipation and experience of painful oesophageal distention. Read More

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September 2018
11 Reads
5.080 Impact Factor

The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health.

Front Microbiol 2018 22;9:1900. Epub 2018 Aug 22.

Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.

The Dipeptidyl peptidase-4 (DPP-4) activity influences metabolic, behavioral and intestinal disorders through the cleavage of key hormones and peptides. Some studies describe the existence of human DPP-4 homologs in commensal bacteria, for instance in or . However, the role of the gut microbiota as a source of DPP-4-like activity has never been investigated. Read More

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First report of concomitant pheochromocytoma and duodenal neuroendocrine tumour in a sporadic multiple endocrine neoplasia type 1.

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

Internal Medicine, Providence Health System, Washington, District of Colombia, USA.

A 77-year-old woman was diagnosed with pheochromocytoma followed by adrenalectomy at age 57. Hyperparathyroidism without osteoprosis was diagnosed at age 58. At age 75, Dual Energy X-ray Absoptiometry (DEXA) revealed osteoporosis and sestamibi scan showed a left parathyroid adenoma. Read More

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September 2018
7 Reads

Bowel Dysfunction in Spinal Cord Injury.

Curr Gastroenterol Rep 2018 Aug 29;20(10):47. Epub 2018 Aug 29.

Neurogastroenterology Unit and Department of Gastroenterology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW, 2065, Australia.

Purpose Of Review: To evaluate and report current evidence regarding the management of bowel dysfunction in spinal cord injury. There is a paucity of high-quality large studies on which to base management advice.

Recent Findings: Recent research has focused on defining the nature of symptomatology of bowel dysfunction in SCI and describing the effects on quality of life and social interactions. Read More

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August 2018
2 Reads

Neonatal factors predictive for respiratory and gastro-intestinal morbidity after esophageal atresia repair.

Pediatr Neonatol 2018 Jul 21. Epub 2018 Jul 21.

Neurogastroenterology and Motility, Gastroenterology, University Hospitals Leuven, Leuven, Belgium; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium; Department of Neurosciences, Experimental ORL, KU Leuven, Belgium.

Background: Esophageal atresia is a major congenital foregut anomaly. Affected patients often suffer from respiratory and gastro-intestinal morbidity. The objective of this study is to identify possible neonatal predictive factors contributing to a long-term complicated clinical course in patients after repair of esophageal atresia. Read More

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July 2018
1 Read

Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system.

Neurogastroenterol Motil 2018 Aug 20:e13451. Epub 2018 Aug 20.

Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.

Background: The Motilis 3D-Transit system tracks electromagnetic capsules as they traverse the gastrointestinal tract. The method is minimally invasive and ambulatory. Analysis has previously been limited to regional gut transit times, but new methods may allow detailed analysis of colonic motility. Read More

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Abdominal distension in health and irritable bowel syndrome: The effect of bladder filling.

Neurogastroenterol Motil 2018 Nov 1;30(11):e13437. Epub 2018 Aug 1.

Neurogastroenterology Unit, University Hospital of South Manchester, Manchester, UK.

Background & Aims: Abdominal distension is a common feature of irritable bowel syndrome (IBS), which is difficult to treat and can have the appearance of late pregnancy. It results from an abnormality of the normal accommodation reflex which keeps abdominal girth constant despite changes in gastrointestinal volume resulting from food ingestion or gas accumulation. We speculated that bladder filling might also trigger this abnormal reflex in IBS and this study tested this hypothesis. Read More

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November 2018
1 Read

Regional gastrointestinal pH profile is altered in patients with type 1 diabetes and peripheral neuropathy.

Neurogastroenterol Motil 2018 Nov 30;30(11):e13407. Epub 2018 Jul 30.

Academic Surgical Unit & Neurogastroenterology Group, Centre for Neuroscience and Trauma Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Background: Gastrointestinal (GI) symptoms, such as nausea and bloating, are common in people with type 1 diabetes (T1DM). Autonomic dysfunction can lead to changes in the GI secreto-motor function which can be associated with GI symptom development. We hypothesized that regional pH profiles in T1DM differs from health and would be associated with objective physiological/clinical markers. Read More

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November 2018
8 Reads

Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders.

J Neurogastroenterol Motil 2018 Oct;24(4):512-527

Behavioral Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.

This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses in regions related to sensory processing of the homeostatic condition of the gut (homeostatic afferent) and responses to salience stimuli (salience network), as well as increased and decreased brain activity in the emotional response areas and reduced activation in areas associated with the top-down modulation of visceral afferent signals. Altered central regulation of the endocrine and autonomic nervous responses, the key mediators of the brain-gut axis, has been demonstrated. Read More

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October 2018
2.700 Impact Factor

Towards microbiome-informed dietary recommendations for promoting metabolic and mental health: Opinion papers of the MyNewGut project.

Clin Nutr 2018 Dec 9;37(6 Pt A):2191-2197. Epub 2018 Jul 9.

Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands.

The gut microbiota coexists in partnership with the human host through adaptations to environmental and physiological changes that help maintain dynamic homeostatic healthy states. Break-down of this delicate balance under sustained exposure to stressors (e.g. Read More

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December 2018
3 Reads

The effect of sildenafil on gastric motility and satiation in healthy controls.

Authors:
F Carbone J Tack

United European Gastroenterol J 2018 Jul 30;6(6):846-854. Epub 2018 Mar 30.

TARGID and Department of Gastroenterology, Neurogastroenterology & Motility, University of Leuven, Leuven, Belgium.

Sildenafil induces relaxation of smooth muscle cells by blocking PDE5. Dyspepsia is one of sildenafil's most frequently reported adverse events, suggesting its effect on gastric motility. Our aim was to study the effect of sildenafil on gastric accommodation (GA) and gastric emptying (GE) in healthy volunteers (HVs). Read More

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July 2018
5 Reads

Gastrointestinal beriberi: a forme fruste of Wernicke's encephalopathy?

Authors:
Sanjay Prakash

BMJ Case Rep 2018 Jul 6;2018. Epub 2018 Jul 6.

Neurology, Smt B K Shah Medical Institute and Research Centre, Vadodara, Gujarat, India.

Gastrointestinal symptoms, such as anorexia, nausea, vomiting and abdominal pain, are very common in patients with Wernicke's encephalopathy (WE). Mild thiamine deficiency may have only gastrointestinal symptoms. We are reporting two patients with thiamine deficiency who predominantly had gastrointestinal symptoms. Read More

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July 2018
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Anorectal Manometry for the Diagnosis of Hirschsprung Disease: New Heights for the Balloon or Just Hot Air?

J Pediatr Gastroenterol Nutr 2018 Sep;67(3):311-312

Neurogastroenterology and Motility Unit, Department of Paediatric Gastroenterology, Great Ormond Street Hospital NHS Foundation Trust.

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September 2018