3,020 results match your criteria Neurocysticercosis


Combined Albendazole and Praziquantel Therapy in an Adult Female with Neurocysticercosis and Generalized Tonic-clonic Seizures.

Cureus 2018 Jul 18;10(7):e2996. Epub 2018 Jul 18.

Department of Pharmacogenomics, Shenandoah University - Inova Center for Personalized Health Icph) Fairfax Campus/Bernard J. Dunn School of Pharmacy, Ashburn, USA.

The use of albendazole monotherapy has been favored as the treatment option for neurocysticercosis. This case reports an incidence of neurocysticercosis in a 32-year-old woman who presented to the emergency department with a generalized tonic-clonic seizure. Neurocysticercosis was confirmed by magnetic resonance imaging (MRI) of the brain and a positive Taenia solium serologic test. Read More

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Taenia solium cysticercosis in West Africa: status update.

Parasite 2018 18;25:49. Epub 2018 Sep 18.

Institut Pasteur de Côte d'Ivoire, B.P. 490, Abidjan 01, Côte d'Ivoire - Institut Pasteur, 25-28 Rue du Dr Roux, 75015 Paris, France.

Cysticercosis is caused by the larvae of the cestode Taenia solium. Few data are available on the prevalence of this disease in pigs and humans in West African countries. The aim of this study was to provide an overview of existing data concerning the spread of this parasitosis in the countries of the Economic Community of West African States (ECOWAS) on the basis of the literature published over the last five decades. Read More

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September 2018

A gel-free proteomic analysis of Taenia solium and Taenia crassiceps cysticerci vesicular extracts.

Parasitol Res 2018 Sep 13. Epub 2018 Sep 13.

Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Góes, Av. Carlos Chagas Filho, Rio de Janeiro, RJ, 373, Brazil.

The taeniasis/cysticercosis complex is a zoonosis caused by the presence of the parasite Taenia solium in humans. It is considered a neglected disease that causes serious public health and economic problems in developing countries. In humans, the most common locations for the larval form are the skeletal muscles, ocular system, and the central nervous system, which is the most clinically important. Read More

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September 2018

Dual Cestode Infection in a Thai Patient (Spinal Sparganosis and Racemose Neurocysticercosis): A Case Report.

Am J Case Rep 2018 Sep 14;19:1090-1095. Epub 2018 Sep 14.

Department of Surgery, Khon Kaen University, Khon Kaen, Thailand.

BACKGROUND Spinal sparganosis and racemose (grape-like) neurocysticercosis are rare diseases. Co-infection with spinal sparganosis and racemose neurocysticercosis has never been reported in the English-language literature. CASE REPORT A 41-year-old male presented after having experienced left hip pain with radiation to the leg, progressive weakness and numbness of the left leg, and difficulty urinating for 4 years, all of which was caused by spinal sparganosis. Read More

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September 2018

New guidelines for the diagnosis and treatment of neurocysticercosis: a difficult proposal for patients in endemic countries.

Expert Rev Neurother 2018 Sep 6:1-5. Epub 2018 Sep 6.

g Division of Neurology Royal University Hospital , University of Saskatchewan , Saskatoon , Canada.

Introduction: Recent guidelines for the diagnosis and treatment for neurocysticercosis (NC) from the Infectious Disease Society of America/American Society of Tropical Medicine and Hygiene were developed to be used in the United States and Canada, where only a small fraction of NC cases occur. Areas covered: The paper discusses the strengths and weakness of the proposed guidelines. Expert commentary: Although these new guidelines bring much needed attention to a neglected parasitic disease, some of the recommendations made are based on insufficient and/or inadequate evidence. Read More

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September 2018

Neurocysticercosis and epilepsy in sub-Saharan Africa.

Brain Res Bull 2018 Aug 28. Epub 2018 Aug 28.

Kinshasa University School of Medicine, Democratic Republic of Congo.

Neurocysticercosis is a public health problem and the leading cause of epilepsy in developing countries especially in sub-Saharan Africa (SSA). In this paper, the authors review the epidemiology of cysticercosis and neurocysticercosis, as well as the non-specific clinical manifestations which render clinical diagnosis challenging especially in the sub-Saharan African context. Special attention is given to the association of epilepsy and neurocysticercosis, the former being the most common symptom of the later, and the role of the later in epileptogenesis is discussed. Read More

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Hippocampal sclerosis induced in mice by a Taenia crassiceps metacestode factor.

J Helminthol 2018 Aug 23:1-7. Epub 2018 Aug 23.

Departamento de Bioquímica y Biología Estructural,Instituto de Fisiología Celular, Universidad Nacional Autónoma de México,Ciudad de México,C.P. 04510 A.P. 70-242.

An experimental Taenia crassiceps mouse model was used to assess the role of Taenia solium metacestode factor (Fac) in human neurocysticercosis. Intraperitoneal infection with T. crassiceps metacestodes or subcutaneous inoculation with a T. Read More

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Acute Symptomatic Seizures and Provoked Seizures: to Treat or Not to Treat?

Curr Treat Options Neurol 2018 Aug 23;20(10):41. Epub 2018 Aug 23.

Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, New York, NY, 10029, USA.

Purpose Of Review: Acute symptomatic and provoked seizures by definition occur in close proximity to an event and are considered to be situational. The treatment implications and likelihood of recurrence of acute symptomatic and provoked seizures differ from unprovoked seizures. In this article, the authors review the literature on acute symptomatic and provoked seizures with regard to therapeutic approach and risk of recurrence. Read More

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August 2018
5 Reads

Parasitic infections of the gut in children.

Paediatr Int Child Health 2018 Aug 22:1-8. Epub 2018 Aug 22.

a Tropical Gastroenterology and Nutrition group , University of Zambia School of Medicine , Lusaka , Zambia.

Parasitic infections of the gut have major implications for child health, but many questions remain unanswered. Protozoal parasites, especially cryptosporidiosis and giardiasis, cause diarrhoea and contribute to impaired growth, neurocognitive development and mortality. Entamoeba histolytica causes dysentery and may have more subtle effects on child growth. Read More

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August 2018
4 Reads

In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions-a metabolic approach.

Drug Deliv Transl Res 2018 10;8(5):1265-1273

State University of Goias, Anapolis, Goias, Brazil.

Neurocysticercosis is the most common parasitic infection of the nervous system and currently represents a serious public health issue in many regions of Latin America, Asia, and Africa. To date, praziquantel is one of the chosen drugs for the treatment of neurocysticercosis. Its mechanism of action is based on the inhibition of different biochemical pathways within the parasite which contribute to its death. Read More

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October 2018
1 Read

Distinguishing neurocysticercosis epilepsy from epilepsy of unknown etiology using a minimal serum mass profiling platform.

Exp Parasitol 2018 Sep 8;192:98-107. Epub 2018 Aug 8.

Dept. of Biostatistics and Epidemiology, University of Oklahoma HSC, Oklahoma City, 73104, USA. Electronic address:

Neurocysticercosis is associated with epilepsy in pig-raising communities with poor sanitation. Current internationally recognized diagnostic guidelines for neurocysticercosis rely on brain imaging, a technology that is frequently not available or not accessible in areas endemic for neurocysticercosis. Minimally invasive and low-cost aids for diagnosing neurocysticercosis epilepsy could improve treatment of neurocysticercosis. Read More

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September 2018

Updates on the management of neurocysticercosis.

Curr Opin Infect Dis 2018 Oct;31(5):377-382

Center for Global Health, Universidad Peruana Cayetano Heredia.

Purpose Of Review: The goal of this review is highlight recent developments regarding neurocysticercosis, including recently developed guidelines.

Recent Findings: Recent diagnostic criteria highlight the importance of neuroimaging in establishing a diagnosis. Monoclonal antibody-based antigen detection and the enzyme-linked immunotransfer blot can be confirmatory. Read More

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October 2018
3 Reads

Experimental murine model of neurocysticercosis: first report of cerebellum as a location for Mesocestoides corti tetrathyridia.

J Helminthol 2018 Aug 1:1-3. Epub 2018 Aug 1.

Laboratorio de Zoonosis Parasitarias,Instituto de Investigaciones en Producción,Sanidad y Ambiente (IIPROSAM),Facultad de Ciencias Exactas y Naturales,Universidad Nacional de Mar del Plata,Funes 3250,7600,Mar del Plata,Argentina.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET),Argentina.

Neurocysticercosis is a parasitic disease caused by encysted larvae of Taenia solium in the human central nervous system. Cysts mainly affect the cerebral hemispheres, although they can also be found in ventricles, basal cisterns, and subarachnoid spaces, and rarely in the cerebellum. Given the impossibility of studying the disease in human patients, Cardona et al. Read More

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Treatment-Resistant Human Extraparenchymal Neurocysticercosis: An Immune-Inflammatory Approach to Cysticidal Treatment Outcome.

Neuroimmunomodulation 2018 24;25(2):103-109. Epub 2018 Jul 24.

Unidad Periférica para el Estudio de Neuroinflamación en Patologías Neurológicas del Instituto de Investigaciones Biomédicas de la UNAM en el Instituto Nacional de Neurología y Neurocirugía, Mexico, Mexico.

Objective: The aim of this study is to analyze the immune-endocrine profile in neurocysticercosis (NC) patients resistant to cysticidal treatment.

Methods: The inflammatory and regulatory responses of 8 resistant NC patients with extraparenchymal parasites and 5 healthy controls were evaluated through flow cytometry. Serum interleukin levels were measured by ELISA and catecholamines levels by high performance liquid chromatography. Read More

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PERSISTENT TAENIA SOLIUM CYSTICERCOSIS IN THE STATE OF MORELOS, MEXICO: HUMAN AND PORCINE SEROPREVALENCE.

J Parasitol 2018 Jul 18. Epub 2018 Jul 18.

Instituto de Investigaciones Biomedicas-Universidad Naciional Autonoma de Mexico Research Immunology Department Instituto de Investigaciones Biomedicas-Universidad Naciional Autonoma de Mexico.

Serological tests are needed to estimate the prevalence of Taenia solium cysticercosis in endemic rural areas. The predictive value of serum antibody levels to diagnose porcine cysticercosis and human neurocysticercosis (NC) was herein assessed by ELISA, using serum samples from 247 backyard pigs (141 without cysticercosis and 106 with cysticercosis) and 183 human subjects (116 non-NC subjects and 67 NC patients) in Central Mexico diagnosed by necropsy and computed tomography, respectively. A sensitivity of 77. Read More

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July 2018
7 Reads

Clinical topography relationship in patients with parenchymal neurocysticercosis and seizures.

Epilepsy Res 2018 Sep 28;145:145-152. Epub 2018 Jun 28.

Center for Global Health - Tumbes, Universidad Peruana Cayetano Heredia, Lima, Peru; Cysticercosis Unit, Department of Transmissible Diseases, Instituto Nacional de Ciencias Neurologicas, Lima, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru.

Objective: Discordances between imaging findings of parenchymal neurocysticercosis and seizure expression have been reported, and as such the possibility that neurocysticercosis and seizures may frequently coexist by chance has been raised. In this study, we evaluate the topographic relationship between seizure foci based on semiology and electroencephalography with the location of parenchymal neurocysticercotic lesions.

Methods: Seizure information, neuroimaging (computed tomography and magnetic resonance imaging [MRI]) and electroencephalographic data from three randomized clinical trials of individuals with parenchymal neurocysticercosis and focal seizures were analyzed. Read More

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September 2018
8 Reads

Clobazam monotherapy for focal or generalized seizures.

Cochrane Database Syst Rev 2018 07 11;7:CD009258. Epub 2018 Jul 11.

Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, E4-145, MLC 2015, 3333 Burnet Avenue, Cincinnati, Ohio, USA, 45229.

Background: This is an updated version of the original Cochrane Review published in Issue 10, 2014. There is a need to expand monotherapy options available to a clinician for the treatment of new focal or generalized seizures. A Cochrane systematic review for clobazam monotherapy is expected to define its place in the treatment of new-onset or untreated seizures and highlight gaps in evidence. Read More

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July 2018
4 Reads

Human taeniasis/cysticercosis: a potentially emerging parasitic disease in Europe.

Ann Gastroenterol 2018 Jul-Aug;31(4):406-412. Epub 2018 Apr 20.

Laboratory of Parasitology and Parasitic Diseases, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece (Isaia Symeonidou, Konstantinos Arsenopoulos, Elias Papadopoulos).

() taeniasis/cysticercosis disease complexes remain a significant challenge for food safety and public health. Human taeniasis is an infectious disease caused by the ingestion of the metacestode larval stage, the cysticerci of in beef or in pork. Humans can also become infected via the ingestion of eggs. Read More

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April 2018
2 Reads

Reversible manifestations of extraparenchymal neurocysticercosis.

Clin Case Rep 2018 Jul 22;6(7):1400-1401. Epub 2018 May 22.

Department of Neurology Hospital de Especialidades Eugenio Espejo Quito Ecuador.

Movement disorders are uncommon manifestations of neurocysticercosis. When present, most are secondary to parenchymal lesions in the basal ganglia. Rarely, movement disorders can occur in racemose/extraparenchymal neurocysticercosis, an aggressive variant frequently associated with cerebrospinal fluid outflow obstruction and hydrocephalus. Read More

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July 2018
3 Reads

Pediatric neurocysticercosis.

Childs Nerv Syst 2018 Jul 9. Epub 2018 Jul 9.

Division of Pediatric Neurosurgery, National Institute of Women, Children and Adolescents Health Fernandes Figueira - Oswaldo Cruz Foundation (IFF - Fiocruz), Rio de Janeiro, RJ, Brazil.

Background: Neurocysticercosis (NCC) is an infestation of the nervous system caused by encysted larvae of Taenia solium. NCC is an important acquired cause of epilepsy and other neurological manifestations especially in endemic areas. NCC in children has pleomorphic manifestations depending on the location, number, viability of the cysts, and host response. Read More

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July 2018
2 Reads

Active neurocysticercosis at the Hospital for Tropical Diseases, London: a clinical case series.

Trans R Soc Trop Med Hyg 2018 Jul;112(7):326-334

Hospital for Tropical Diseases, University College Hospital, London.

Background: Neurocysticercosis is the commonest infectious cause of epilepsy in endemic countries, and accounts for a greater number of cases worldwide than any other single pathology. Infection is associated with long-term exposure in low-income countries, although acquisition after travel has been recognized. The standard of care in the UK is inpatient treatment with anti-helminthic drugs and steroids. Read More

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July 2018
5 Reads

Next-Generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Neurocysticercosis.

Front Neurol 2018 19;9:471. Epub 2018 Jun 19.

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Neurocysticercosis (NCC) is the most common helminthic infection of the central nervous system (CNS). The diagnosis of NCC is sometimes challenging due to its heterogenous clinical manifestations and the variable sensitivity and specificity of neuroimaging and serological tests. Next-generation sequencing (NGS) of cerebrospinal fluid (CSF) was used to detect pathogens in patients with clinically suspected CNS infections. Read More

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June 2018
4 Reads

Neurocysticercosis in Children with Seizures: A Cross-Sectional Study.

Int J Pediatr 2018 21;2018:1030878. Epub 2018 May 21.

Department of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, Nepal.

Background: Neurocysticercosis (NCC), a common cause of seizures in children from low and middle income countries (LMICs), if not diagnosed and treated early enough may lead to considerable morbidity and mortality. There is a lack of data on the prevalence of NCC and its clinical characteristics among those with seizure in South-Western Nepal.

Aims And Objectives: To study the prevalence and clinical characteristics of NCC in children with seizures. Read More

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May 2018
7 Reads

Galectin-3 in M2 Macrophages Plays a Protective Role in Resolution of Neuropathology in Brain Parasitic Infection by Regulating Neutrophil Turnover.

J Neurosci 2018 Jul 26;38(30):6737-6750. Epub 2018 Jun 26.

Department of Biomedical Sciences, School of Medicine & Health Sciences, University of North Dakota, Grand Forks, North Dakota 58202

Macrophages/microglia with M2-activation phenotype are thought to play important anti-inflammatory and tissue reparative functions in the brain, yet the molecular bases of their functions in the CNS remain to be clearly defined. In a preclinical model of neurocysticercosis using brain infection with a parasite , we previously reported the presence of large numbers of M2 cells in the CNS. In this study using female mice, we report that M2 macrophages in the parasite-infected brain display abundant galectin-3 expression. Read More

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July 2018
1 Read

Calcified Neurocysticercosis and Headache in an Endemic Village: A Case-Control Study Nested to a Population-Based Cohort.

Am J Trop Med Hyg 2018 Sep 21;99(3):729-734. Epub 2018 Jun 21.

School of Medicine, Stony Brook University, New York, New York.

Headache in patients with calcified neurocysticercosis (NCC) is probably common but has been largely overlooked. We aimed to assess the presence, characteristics, and diagnosis of headache across patients with calcified NCC and their matched controls. In this case-control study nested to a population-based cohort, Atahualpa residents aged ≥ 20 years with calcified NCC were identified as case patients and paired 1:1 to age- and gender-matched randomly selected controls. Read More

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September 2018
3 Reads

Comparison of telephone with face to face consultation for follow up of Neurocysticercosis.

Epilepsy Res 2018 Sep 12;145:110-115. Epub 2018 Jun 12.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Objectives: There is significant scarcity of specialists to provide care for children with epilepsy in many parts of the world. Telemedicine is a potential future option. This study was planned to estimate the diagnostic accuracy of telephone consultation to identify Critical Clinical Events (breakthrough seizures, drug non-compliance, drug adverse events, features of raised intracranial pressure, and other disease-related events),compared to the Face-to-Face consultation (gold standard), in children with Neurocysticercosis (NCC) and symptomatic seizures, following the completion of cysticidal therapy. Read More

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September 2018
1 Read

Solitary Brain Mass in a Patient with Seizures: An Unexpected Infectious Etiology.

Diseases 2018 Jun 22;6(3). Epub 2018 Jun 22.

Division of Infectious Diseases, Department of Medicine, Huntsville Hospital, Huntsville, AL 35801, USA.

Neurocysticercosis is a parasitosis caused by the larval stage of the pork tapeworm The diagnosis is challenging as morphology on neuroimaging can be inconclusive and serology is frequently negative. We describe the case of a 24-year old Hispanic man who presented with seizures and loss of consciousness. Magnetic resonance imaging (MRI) showed a cystic mass in right frontal lobe. Read More

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June 2018
2 Reads

Notes and recommendations for the establishment of control programs for taeniasis and cysticercosis due to Taenia solium in PeruNotes and recommendations for the establishment of control programs for Taeniasis/cysticercosis in Peru.

Rev Peru Med Exp Salud Publica 2018 Jan-Mar;35(1):132-138

Departamento de Salud Internacional, Johns Hopkins University. Baltimore, Maryland, EE. UU.

Neurocysticercosis is a nervous system infection caused by the larvae (cysticercus) of the pork tapeworm (Taenia solium). Neurocysticercosis is the primary cause of acquired epilepsy worldwide and, therefore, a global public health problem. On the other hand, T. Read More

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October 2017
6 Reads

Posterior Fossa Craniotomy for Adherent Fourth Ventricle Neurocysticercosis.

Oper Neurosurg (Hagerstown) 2018 Jun 14. Epub 2018 Jun 14.

Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan.

Background And Importance: Neurocysticercosis (NCC) is an infectious helminthic disease often presenting in patients who have immigration or travel history from areas where NCC is endemic. Fourth ventricle cysts from NCC pose a unique treatment challenge, as there is little consensus on the best treatment. This case study describes the treatment of a patient with fourth ventricle neurocysticercosis (FVNCC), examines the therapeutic decision-making, and provides a video of a posterior fossa craniotomy (PFC) resection of a degenerative cyst. Read More

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June 2018
15 Reads

Epidemiology of central nervous system infectious diseases: a meta-analysis and systematic review with implications for neurosurgeons worldwide.

J Neurosurg 2018 Jun 15:1-20. Epub 2018 Jun 15.

Global Neurosurgery Initiative, Program in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; and.

OBJECTIVE Central nervous system (CNS) infections cause significant morbidity and mortality and often require neurosurgical intervention for proper diagnosis and treatment. However, neither the international burden of CNS infection, nor the current capacity of the neurosurgical workforce to treat these diseases is well characterized. The objective of this study was to elucidate the global incidence of surgically relevant CNS infection, highlighting geographic areas for targeted improvement in neurosurgical capacity. Read More

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June 2018
10 Reads
3.74 Impact Factor

Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice.

Arq Neuropsiquiatr 2018 May;76(5):339-345

Universidade Federal de Goiás, Instituto de Saúde Pública, Patologia Tropical, Goiânia GO, Brasil.

Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. Read More

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May 2018
6 Reads

Disseminated cysticercosis with asymptomatic neurocysticercosis.

Indian J Dermatol Venereol Leprol 2018 Jun 11. Epub 2018 Jun 11.

Department of Radiology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

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June 2018
1 Read

Carotid Oncosphere Infection: A Novel Porcine Neurocysticercosis Model.

Am J Trop Med Hyg 2018 Aug 7;99(2):380-387. Epub 2018 Jun 7.

Microbiology of the School of Science, Universidad Peruana Cayetano Heredia, Lima, Peru.

Neurocysticercosis (NCC), the infection of the human central nervous system (CNS) with larval cysts of causes widespread neurological morbidity. Animal models are crucial for studying the pathophysiology and treatment of NCC. Some drawbacks of current NCC models include differences in the pathogenesis of the model and wild-type parasite, low rates of infection efficiency and lack of reproducibility. Read More

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August 2018
8 Reads
2.70 Impact Factor

Arterial spin labeling perfusion: Prospective MR imaging in differentiating neoplastic from non-neoplastic intra-axial brain lesions.

Neuroradiol J 2018 Jan 1:1971400918783058. Epub 2018 Jan 1.

5 Department of Neurosurgery, SGPGIMS, Lucknow, Uttar Pradesh, India.

Purpose The purpose of this article is to assess the diagnostic performance of arterial spin-labeling (ASL) magnetic resonance perfusion imaging to differentiate neoplastic from non-neoplastic brain lesions. Material and methods This prospective study included 60 consecutive, newly diagnosed, untreated patients with intra-axial lesions with perilesional edema (PE) who underwent clinical magnetic resonance imaging including ASL sequences at 3T. Region of interest analysis was performed to obtain mean cerebral blood flow (CBF) values from lesion (L), PE and normal contralateral white matter (CWM). Read More

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January 2018
7 Reads

Laboratory Diagnosis of Neurocysticercosis (Taenia solium).

J Clin Microbiol 2018 Sep 27;56(9). Epub 2018 Aug 27.

Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Neurocysticercosis accounts for approximately 30% of all epilepsy cases in most developing countries. The immunodiagnosis of cysticercosis is complex and strongly influenced by the course of infection, the disease burden, the cyst location, and the immune response of the host. The main approach to immunodiagnosis should thus be to evaluate whether the serological results are consistent with the diagnosis suggested by imaging. Read More

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September 2018
11 Reads

Pre-hospitalization, hospitalization, and post-hospitalization costs of patients with neurocysticercosis treated at the Instituto Nacional de Neurologia y Neurocirugia (INNN) in Mexico City, Mexico.

Rev Inst Med Trop Sao Paulo 2018 28;60:e20. Epub 2018 May 28.

Department of Veterinary Integrative Biosciences, Texas A&M University College of Veterinary Medicine & Biomedical Sciences, College Station, Texas, United States.

The objective of this study was to estimate the direct costs associated with the diagnosis and treatment of neurocysticercosis (NCC) during pre-hospitalization, hospitalization, and post-hospitalization periods for 108 NCC patients treated at the Instituto Nacional de Neurologia y Neurocirugia (INNN) in Mexico City, Mexico. Information on clinical manifestations, diagnostic tests, hospitalizations, surgical procedures, prescription medication, and other treatments was collected via medical chart reviews. Uncertain values for costs and frequency of treatments were imputed using bootstrap techniques. Read More

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June 2018
7 Reads

ELISA based on a recombinant Paragonimus heterotremus protein for serodiagnosis of human paragonimiasis in Thailand.

Parasit Vectors 2018 May 30;11(1):322. Epub 2018 May 30.

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.

Background: Paragonimus heterotremus is the main causative agent of paragonimiasis in Thailand. In Western blot diagnostic assays for paragonimiasis, the 35 kDa band present in crude P. heterotremus somatic extracts represents one of the known diagnostic bands. Read More

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May 2018
1 Read

The Many Faces of Neurocysticercosis.

J Neurol Sci 2018 Jul 12;390:75-76. Epub 2018 Apr 12.

Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

Neurocysticercosis (NCC) is the most common parasitic disease of the central nervous system, and one of the most common causes of epilepsy worldwide. The radiologic appearance of neurocysticercosis varies depending on the stage of the disease, and the stage of the disease determines the appropriate treatment. In this article, we review key neuroimaging characteristics of the stages of NCC (vesicular, colloidal, granular, and calcified) and treatment principles for these different stages of the disease. Read More

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Role of Immuno-Polymerase Chain Reaction (I-PCR) in Resolving Diagnostic Dilemma Between Tuberculoma and Neurocysticercosis: A Case Report.

Am J Case Rep 2018 May 24;19:599-603. Epub 2018 May 24.

Centre for Biotechnology, Maharshi Dayanand University (MDU), Rohtak, Haryana, India.

BACKGROUND Tuberculoma and neurocysticercosis (NCC) often show similar clinical and neuroimaging features. Differential diagnosis of these 2 diseases is imperative, as tuberculoma is an active infection that requires immediate anti-tubercular therapy (ATT). CASE REPORT We present the case of a 17-year-old Indian girl with fever, severe headache, and right 6th cranial nerve palsy. Read More

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May 2018
1 Read

Antiparasitic Dosing Discrepancy in the 2017 Neurocysticercosis Guidelines.

Clin Infect Dis 2018 May 22. Epub 2018 May 22.

Department of Pharmacy Services - Cedars-Sinai Medical Center: Los Angeles, California, U.S.

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Diagnosis and treatment of Neurocysticercosis: Issues that need to be addressed.

Clin Infect Dis 2018 May 22. Epub 2018 May 22.

Department of Neurology, King George's Medical University, U.P., Lucknow, INDIA.

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Pregnancy screening and monitoring of Albendazole therapy for Neurocysticercosis.

Clin Infect Dis 2018 May 22. Epub 2018 May 22.

Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA.

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Inflammation is a key risk factor for persistent seizures in neurocysticercosis.

Ann Clin Transl Neurol 2018 May 10;5(5):630-639. Epub 2018 Apr 10.

Department of Neurology and Rehabilitation Medicine University of Illinois at Chicago Chicago Illinois.

Objective: We conducted a retrospective, case-control study of neurocysticercosis patients to ascertain early markers that identify subjects likely to develop treatment-resistant seizures.

Methods: Clinical histories and imaging studies from 38 neurocysticercosis patients who had been followed for 18 months after treatment were evaluated. Both pairwise and multifactorial analyses were conducted to identify factors associated with continued seizures. Read More

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May 2018
1 Read

Prevalence and risk factors for Taenia solium cysticercosis in school-aged children: A school based study in western Sichuan, People's Republic of China.

PLoS Negl Trop Dis 2018 05 8;12(5):e0006465. Epub 2018 May 8.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, United States of America.

Background: Taenia solium cysticercosis affects millions of impoverished people worldwide and can cause neurocysticercosis, an infection of the central nervous system which is potentially fatal. Children may represent an especially vulnerable population to neurocysticercosis, due to the risk of cognitive impairment during formative school years. While previous epidemiologic studies have suggested high prevalence in rural China, the prevalence in children as well as risk factors and impact of disease in low-resource areas remain poorly characterized. Read More

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May 2018
1 Read

Repeated Peritoneal Catheter Blockage Caused by Neurocysticercosis Following Ventriculoperitoneal Shunt Placement for Hydrocephalus.

J Neurosci Rural Pract 2018 Apr-Jun;9(2):268-271

Department of Neurosurgery, The First Affiliated Hospital, Zhengzhou, China.

Cerebral cysticercosis is common, but the possibility for repeated occurrence of peritoneal catheter blockage caused by neurocysticercosis (NCC) after two revisions following ventriculoperitoneal shunt placement for hydrocephalus is unusual. Herein, we describe one rare case in which peritoneal catheter revision was performed two times unsuccessfully. Endoscopic cysternostomy rather than peritoneal catheter adjustment was performed successfully, and histopathological examination of excised cystic samples confirmed NCC in our hospital. Read More

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May 2018
4 Reads

Ventricular Neurocysticercosis: A Severe Form of the Disease Waiting for Well-Designed Therapeutic Trials.

Am J Trop Med Hyg 2018 Jun 26;98(6):1553-1554. Epub 2018 Apr 26.

School of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador.

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Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing.

JAMA Neurol 2018 Aug;75(8):947-955

Department of Biochemistry and Biophysics, UCSF, San Francisco.

Importance: Identifying infectious causes of subacute or chronic meningitis can be challenging. Enhanced, unbiased diagnostic approaches are needed.

Objective: To present a case series of patients with diagnostically challenging subacute or chronic meningitis using metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) supported by a statistical framework generated from mNGS of control samples from the environment and from patients who were noninfectious. Read More

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August 2018
4 Reads
1 PubMed Central Citation(source)

Intraventricular Neurocysticercosis: Experience and Long-Term Outcome from a Tertiary Referral Center in the United States.

Am J Trop Med Hyg 2018 Jun 19;98(6):1755-1762. Epub 2018 Apr 19.

Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Ventricular involvement in neurocysticercosis (NCC), a common serious manifestation of NCC, has distinct clinical presentations, complications, and treatments primarily because of partial or complete obstruction of the cerebrospinal fluid (CSF) flow by cysts. We review the clinical course, treatments, and long-term outcomes in 23 of 121 (19.0%) total NCC patients with ventricular cysts referred to the National Institutes of Health from 1985 to the October 2017. Read More

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Long-term Cognitive Outcome of Children With Parenchymal Neurocysticercosis: A Prospective Observation Study.

J Child Neurol 2018 Jun 24;33(7):468-473. Epub 2018 Apr 24.

2 Department of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

To study the cognitive profile and scholastic performance of children with parenchymal neurocysticercosis. A total of 500 children with a diagnosis of neurocysticercosis and epilepsy registered in our pediatric neurocysticercosis clinic between January 1996 and December 2002 were enrolled. Patients were evaluated for their scholastic performance using their school grades. Read More

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June 2018
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No association of IL2, IL4, IL6, TNF, and IFNG gene polymorphisms was found with Taenia solium human infection or neurocysticercosis severity in a family-based study.

Hum Immunol 2018 Jul 21;79(7):578-582. Epub 2018 Apr 21.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico. Electronic address:

Neurocysticercosis (NC) is caused by the establishment of the metacestode stage of Taenia solium in the human central nervous system. A great heterogeneity in the susceptibility to the infection and to the disease has been reported. While the factors involved in this heterogeneity are not completely understood, clearly different immune-inflammatory profiles have been associated to each condition. Read More

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