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    Chiari Malformation and Hydrocephalus Masking Neurocysticercosis: A Case Report.
    World Neurosurg 2018 Mar 12. Epub 2018 Mar 12.
    Boulder Neurosurgical Associates, Boulder, Colorado, USA; Justin Parker Neurological Institute, Boulder, Colorado, USA.
    Background: The variety of diagnostic characteristics associated with neurocysticercosis have been well studied, however, its potential to be implicated in other differential diagnosis has not been well demonstrated.

    Case Description: We report the case of a 55-year-old Hispanic man who underwent a Chiari decompression surgery, which was complicated with hydrocephalus. Despite a ventriculoperitoneal (VP) shunt placement, he continued to have headaches and was soon found to have several skull base subarachnoid lesions, which were later diagnosed as the sequelae of an active neurocysticercosis infection. Read More

    Assessment of the societal cost of Taenia solium in Angónia district, Mozambique.
    BMC Infect Dis 2018 03 13;18(1):127. Epub 2018 Mar 13.
    Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
    Background: The zoonotic parasite Taenia solium is endemic in Angónia district, Tete province, Mozambique, though the burden of the disease complex is unknown.

    Methods: As part of two cross-sectional studies on human and porcine cysticercosis in the area, unique epidemiological and cost data were collected in Angónia district, Mozambique in 2007. These data provided the basis for the assessment of the societal cost of T. Read More

    Recurrent encephalopathy in milliary neurocysticercosis: An uncommon manifestation of a common infection.
    J Infect Public Health 2018 Mar 9. Epub 2018 Mar 9.
    Pediatric Neurology and Neurodevelopment Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:
    Neurocysticercosis is a common parasitic infection in children in developing countries and neurological symptoms such as seizures are the most common manifestations. However, symptoms of encephalopathy are an unusual presentation in children. A 4-year-old boy presented with recurrent episodes of febrile encephalopathy. Read More

    Neurocysticercosis: the good, the bad, and the missing.
    Expert Rev Neurother 2018 Mar 14:1-13. Epub 2018 Mar 14.
    f Departamento de Medicina , Universidade de Taubaté , São Paulo , Brazil.
    Introduction: Neurocysticercosis (NC) is a neglected disease that contributes substantially to neurological morbidity/mortality in lower-income countries and increasingly among high-income countries due to migration. Many advances have been made in understanding NC, but unanswered questions remain Areas covered: This review discusses the epidemiology, pathophysiology, immunology, diagnosis, treatment, and eradication of NC. Expert commentary: The global NC prevalence remains unknown and needs proper ascertainment. Read More

    Next generation sequencing based pathogen analysis in a patient with neurocysticercosis: a case report.
    BMC Infect Dis 2018 03 6;18(1):113. Epub 2018 Mar 6.
    Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
    Background: Accurate and early diagnosis of neurocysticercosis (NCC) remains a challenge due to the heterogeneity of its clinical, immunological and imaging characteristics. The presence of cysticercus DNA in cerebrospinal fluid (CSF) of NCC patients has been previously detected via conventional PCR assays. To the best of our knowledge, the use of CSF Next-Generation Sequencing (NGS) based pathogen analysis in patients with NCC infection has never been reported. Read More

    Isolated Intramedullary Spinal Cysticercosis: A Case Report with Review of Literature of a Rare Presentation.
    Asian J Neurosurg 2018 Jan-Mar;13(1):154-156
    Department of Neurosurgery and Microbiology, J.N Medical College and KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, KLE University, Belgaum, Karnataka, India.
    A number of parasitic infections can involve the central nervous system of which neurocysticercosis (NCC) is the most common one in developing countries. Most often the brain is involved, spine and spinal cord involvement is very rare and intramedullary involvement is rarer still. Here, we report a 30-year-old male patient, with intramedullary NCC of dorsal spinal cord. Read More

    HDP2: a ribosomal DNA (NTS-ETS) sequence as a target for species-specific molecular diagnosis of intestinal taeniasis in humans.
    Parasit Vectors 2018 Feb 27;11(1):117. Epub 2018 Feb 27.
    Parasitology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Crtra, Majadahonda-Pozuelo, km 2.2, 28220, Majadahonda, Madrid, Spain.
    Background: Taenia solium, T. asiatica and T. saginata tapeworms cause human taeniasis and are the origin of porcine and bovine cysticercosis. Read More

    [Evaluation of ELISA kit for detection of serum specific IgG antibodies againstin diagnosis of human cysticercosis].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Mar;29(2):228-230
    Sichuan Center for Diseases Control and Prevention, Chengdu 610041, China.
    Objective: To evaluate the ELISA kit for detection of IgG antibodies againstcysticercus in humans, so as to provide a reference for its application in clinical practice.

    Methods: The sera collected from the patients with neurocysticercosis, echinococcosis, taeniasis and healthy people, respectively, were checked by ELISA for specific IgG antibodies againstcysticercus, as described in the instruction of the kit.

    Results: Of the 30 patients with neurocysticercosis at active stage, 28 showed seropositive reaction, indicating a sensitivity of 93. Read More

    Endoscopic Management of Intraventricular Neurocysticercosis.
    Turk Neurosurg 2018 Jan 22. Epub 2018 Jan 22.
    Dr. Ram Manohar Lohia Institute of Medical Sciences, Department of Neurosurgery, Lucknow, India.
    Objective Restoration of CSF flow and removal of Intraventricular Cystecercal Cyst is the main goal in treatment Hydrocephalus due Intraventricular Neurocysticercosis. The purpose of this study was to evaluate the technique and outcome of Endoscopic management of Intraventricular Neurocysticercosis. Methods We retrospectively analysed the records of 30 consecutive patients of Intraventricular Intra third and fourth ventricle Neurocysticercosiswho underwent endoscopic management. Read More

    Seroprevalence of human cysticercosis in Jataí, Goiás state, Brazil.
    Braz J Infect Dis 2018 Feb 9. Epub 2018 Feb 9.
    Universidade Federal de Goiás, Laboratório de Imunologia, Jataí, GO, Brazil. Electronic address:
    The Taenia solium cysticercosis affects millions of people worldwide and is considered a public health problem, especially in developing countries. The diagnosis of neurocysticercosis (NCC) is complex and involves the analysis of epidemiological, clinical, neuroimaging, and immunological host data. NCC is endemic in Brazil, and is related to the cause of death mainly in the Southeast, South, and Central-West regions. Read More

    An uncommon manifestation of a common disease
    Ann Parasitol 2017 ;63(4):357-360
    Department of Medicine, Topiwala National Medical College and B.Y.L. Nair Ch. Hospital, Mumbai-400 008, India
    Neurocysticercosis is the common parasitic disease of the central nervous system. One of the uncommon manifestations and a rare complication is its disseminated form. Human cysticercosis is caused by the spreading of the embryo of Taenia solium in the intestine via the hepatoportal system to different tissues and internal organs of the body. Read More

    [Neuroendocrine effects of helminthiases (A review)].
    Parazitologiia 2017 Mar-Apr;51(2):97-103
    Nowadays the number of patients diagnosed with helminthiases shows tendency for steady growth around the world. During last few years, researches in the field of immunology have again turned their attention towards the question of parasitological immunity and tissue response. Helminthiases and other parasitic diseases in some instances can induce central nervous system disorders and violate human behavioral reactions. Read More

    68Ga-Prostate-Specific Membrane Antigen Expression in Neurocysticercosis Lesions in a Patient With Prostate Carcinoma.
    Clin Nucl Med 2018 Apr;43(4):e122-e124
    Ga-prostate-specific membrane antigen (PSMA) ligand is a well-known tracer used in prostate cancer. Nevertheless, there are reports of unusual Ga-PSMA uptake in variety of benign lesions. We report a case of prostate cancer in which Ga-PSMA PET/CT revealed tracer avidity in the enhancing walls of cystic lesions in the brain consistent with the features of neurocysticercosis. Read More

    Diffusion tensor imaging metrics in cystic intracranial mass lesions.
    Indian J Radiol Imaging 2017 Oct-Dec;27(4):457-462
    Consultant Radiologist, Scansworld Research and Education Institute, Chennai, Tamil Nadu, India.
    Background And Purpose: Conventional MR does not always differentiate various cystic lesions of brain. Our purpose was to explore the utility of DTI in characterization & differentiation of intra cranial cystic mass lesions.

    Materials And Methods: DTI was done with a clinical 1. Read More

    Dynamic contrast-enhanced (DCE) MRI derived kinetic perfusion indices may help predicting seizure control in single calcified neurocysticercosis.
    Magn Reson Imaging 2018 Jan 27;49:55-62. Epub 2018 Jan 27.
    Department of Neurology, King George Medical University Uttar Pradesh, Lucknow, India.
    Background: The factors responsible for seizure recurrence in patients with Solitary calcified neurocysticercosis (NCC) are not well understood. Blood brain barrier (BBB) breach may be associated with seizure recurrence. Dynamic contrast enhanced (DCE) MRI derived indices kkand vare useful in quantifying BBB permeability. Read More

    A Rare Pediatric Case of Neurocysticercosis Misdiagnosed As Brain Abscess.
    Turkiye Parazitol Derg 2017 Dec;41(4):223-225
    Dr. Sami Ulus Kadın Doğum, Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi, Çocuk Enfeksiyon Hastalıkları Kliniği, Ankara, Türkiye.
    Neurocysticercosis is a parasitic infection of the central nervous system caused by the larval stage of Taenia solium. Although this zoonotic infection is one of the major public health problems in some developing countries, it is extremely rare in Turkey. In this article, we present the case of a pediatric patient with neurocysticercosis who was misdiagnosed with brain abscess because of focal seizures in another hospital. Read More

    Mapping the residual incidence of taeniasis and cysticercosis in Colombia, 2009-2013, using geographical information systems: Implications for public health and travel medicine.
    Travel Med Infect Dis 2017 Dec 27. Epub 2017 Dec 27.
    Department of Microbiology and Parasitology, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico city, Mexico.
    Background: In Colombia, taeniasis and cysticercosis have been significantly reduced over the past decades, however still reported with implications for public health and travel medicine.

    Methods: An observational, retrospective study, in which the incidence of taeniasis and cysticercosis (ICD-10 codes B68s/B69s) in Colombia, 2009-2013, was estimated based on data extracted from the Individual Health Records System (Registro Individual de Prestación de Servicios, RIPS) was performed. The Geographic Information System (GIS) generated national maps showing the distribution of taeniasis and cysticercosis by department by year. Read More

    Evaluating the Recombinant T24H Enzyme-Linked Immunoelectrotransfer Blot Assay for the Diagnosis of Neurocysticercosis in a Panel of Samples from a Large Community-Based Randomized Control Trial in 60 Villages in Burkina Faso.
    Am J Trop Med Hyg 2018 Feb 21;98(2):565-569. Epub 2017 Dec 21.
    Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
    Current guidelines for the diagnosis of neurocysticercosis (NCC) recommend the use of the lentil lectin-bound glycoprotein enzyme-linked immunoelectrotransfer blot assay (LLGP-EITB) as the reference standard for serological testing. In response to the drawbacks involved with the use of the LLGP-EITB, a recombinant T24H antigen (rT24H) EITB assay was developed, with promising results. However, the test has yet to be evaluated among individuals from sub-Saharan Africa (SSA). Read More

    Neuroimaging of Dilated Perivascular Spaces: From Benign and Pathologic Causes to Mimics.
    J Neuroimaging 2018 Mar 27;28(2):139-149. Epub 2017 Dec 27.
    Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
    Perivascular spaces (PVSs), also known as Virchow-Robin spaces, are pial-lined, fluid-filled structures found in characteristic locations throughout the brain. They can become abnormally enlarged or dilated and in rare cases can cause hydrocephalus. Dilated PVSs can pose a diagnostic dilemma for radiologists because of their varied appearance, sometimes mimicking more serious entities such as cystic neoplasms, including dysembryoplastic neuroepithelial tumor and multinodular and vacuolating neuronal tumor, or cystic infections including toxoplasmosis and neurocysticercosis. Read More

    Spontaneously Arrested Transmission of Cysticercosis in a Highly Endemic Village with a Very Low Migration Rate.
    Am J Trop Med Hyg 2018 Mar 14;98(3):776-778. Epub 2017 Dec 14.
    Cysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
    cysticercosis is difficult to eliminate without interventions or societal development. Atahualpa is a rural Ecuadorian village with documented low migration rate, where domestic pig raising is common and human cysticercosis is endemic. To assess neurocysticercosis (NCC) prevalence, 1,273 villagers aged ≥ 20 years underwent neuroimaging studies, which showed calcified lesions in 121 (9. Read More

    Intraventricular neurocysticercosis with interventricular foramen and generalized ventriculitis.
    Int J Infect Dis 2018 02 7;67:82-83. Epub 2017 Dec 7.
    Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:

    Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia.
    Epilepsy Behav 2018 Mar 6;80:354-359. Epub 2017 Dec 6.
    Department of Neurology, Medical University Center Göttingen, Göttingen, Germany; Institute for Acute Neurology and Stroke, Academic Teaching Hospital Feldkirch, Feldkirch, Austria. Electronic address:
    Cognitive impairment and quality of life (Qol) are important to assess the burden of epilepsy and neurocysticercosis (NCC), which are common but neglected in Sub-Saharan Africa (SSA). The aims of this study were to assess cognitive performance and Qol of people with epilepsy (PWE) in Zambia and to explore differences in PWE with and without NCC. In this community based, cross-sectional case-control-study, 47 PWE and 50 healthy controls completed five neuropsychological tests (Mini Mental State Examination (MMSE), Digit Span, Selective Reminding Test (SRT), Spatial Recall Test (SPART), Test Battery of Attentional Performance (TAP)) and a World Health Organization (WHO) questionnaire of Qol. Read More

    Yield of Brain MRI in Clinically Diagnosed Epilepsy in the Kingdom of Bhutan: A Prospective Study.
    Ann Glob Health 2017 May - Aug;83(3-4):415-422. Epub 2017 Apr 7.
    Department of Neurology, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:
    Background: People with epilepsy (PWE) in low- and middle-income countries may not access the health resources that are considered optimal for epilepsy diagnosis. The diagnostic yield of magnetic resonance imaging (MRI) has not been well studied in these settings.

    Objectives: To report the diagnostic yield of brain MRI and identify clinical associations of abnormal MRI findings among PWE in a neurocysticercosis-endemic, resource-limited setting and to identify the proportion and putative structural brain causes of drug-resistant epilepsy. Read More

    Neurocysticercosis among People Living Near Pigs Heavily Infected with Cysticercosis in Rural Endemic Peru.
    Am J Trop Med Hyg 2018 Feb 30;98(2):558-564. Epub 2017 Nov 30.
    School of Public Health, Oregon Health & Science University and Portland State University, Portland, Oregon.
    Neurocysticercosis causes substantial neurologic morbidity in endemic regions around the world. In this cross-sectional study, we describe the frequency of neurocysticercosis among a presumed high-risk group of people in an endemic community in northern Peru. Participants who screened positive on a nine-question seizure survey were evaluated clinically to diagnose epilepsy using International League Against Epilepsy criteria. Read More

    TNF-α blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis.
    PLoS Negl Trop Dis 2017 Nov 30;11(11):e0006059. Epub 2017 Nov 30.
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
    Background: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, which generally requires corticosteroid treatment to control inflammation. The nature of this response and how to best control it is unclear. Read More

    Low sensitivity and frequent cross-reactions in commercially available antibody detection ELISA assays for Taenia solium cysticercosis.
    Trop Med Int Health 2018 Jan 7;23(1):101-105. Epub 2017 Dec 7.
    Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Perú.
    Objective: To evaluate the diagnostic performance of two commercially available ELISA kits, Novalisaand Ridascreen, for the detection of antibodies to Taenia solium, compared to serological diagnosis of neurocysticercosis (NCC) by LLGP-EITB (electro-immunotransfer blot assay using lentil-lectin purified glycoprotein antigens).

    Methods: Archive serum samples from patients with viable NCC (n = 45) or resolved, calcified NCC (n = 45), as well as sera from patients with other cestode parasites (hymenolepiasis, n = 45 and cystic hydatid disease, n = 45), were evaluated for cysticercosis antibody detection using two ELISA kits, Novalisaand Ridascreen. All NCC samples had previously tested positive, and all samples from heterologous infections were negative on LLGP-EITB for cysticercosis. Read More

    Reciprocal contribution of clinical studies and the HP10 antigen ELISA for the diagnosis of extraparenchymal neurocysticercosis.
    Acta Trop 2018 Feb 16;178:119-123. Epub 2017 Nov 16.
    Instituto de investigaciones Biomédicas "Dr. Francisco J. Triana-Alonso" Facultad de Ciencias de la Salud, Edo. Aragua. Universidad de Carabobo, Venezuela. Electronic address:
    To evaluate diagnosis of active neurocysticercosis, paired cerebral spinal fluid (CSF) and serum samples from 24 neurocysticercosis (NCC) patients and 17 control neurological patients were assayed in the HP10 Taenia antigen (Ag) ELISA. The CSF samples were also tested with an HP10 Lateral Flow Assay (LFA). The HP10 Ag was detected by ELISA in the CSF of 5/5 patients with Definitive extraparenchymal NCC, and in 4/5 of the corresponding sera. Read More

    A case of cerebral tuberculoma mimicking neurocysticercosis.
    Acute Med Surg 2017 Jul 4;4(3):329-333. Epub 2017 Apr 4.
    Department of Emergency and Critical Care MedicineTokyo Women's Medical University Yachiyo Medical CenterYachiyo ChibaJapan.
    Case: A 42-year-old Peruvian woman residing in Japan for 11 years with a family history of neurocysticercosis presented to our intensive care unit with fever and intense headache.Computed tomography indicated multiple micronodular lesions in the brain parenchyma, and cerebral tuberculoma and neurocysticercosis were considered in the differential diagnosis. Neurocysticercosis was initially suspected, and oral praziquantel was initiated. Read More

    Radiological Diagnoses in the Context of Emigration: Infectious diseases.
    Rofo 2018 Feb 3;190(2):121-133. Epub 2017 Nov 3.
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany.
    Background:  Globalization and emigration impact on the spectrum of diseases challenging health care systems. Medical practitioners have to particularly prepare for infectious diseases.

    Methods:  The database of a health care center specialized on tropical medicine was screened for patients with history of migration and one of the following diagnoses: Cystic echinococcosis, tuberculosis, schistosomiasis, visceral leishmaniosis, and neurocysticercosis. Read More

    Neurocysticercosis as an infectious acquired epilepsy worldwide.
    Seizure 2017 Nov 7;52:176-181. Epub 2017 Oct 7.
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
    Aside from brain injury and genetic causes, there is emerging information on brain infection and inflammation as a common cause of epilepsy. Neurocysticercosis (NCC), the most common cause of epilepsy worldwide, is caused by brain cysts from the Taenia solium tapeworm. In this article, we provide a critical analysis of current and emerging information on the relationship between NCC infection and epilepsy occurrence. Read More

    MicroRNAs inNeurocysticercosis: Insights as Promising Agents in Host-Parasite Interaction and Their Potential as Biomarkers.
    Front Microbiol 2017 29;8:1905. Epub 2017 Sep 29.
    Neurocysticercosis Lab, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
    MicroRNAs (miRNAs) are short, endogenous, non-coding, single-stranded RNAs involved in post-transcriptional gene regulation. Although, several miRNAs have been identified in parasitic helminths, there is little information about their identification and function in. Furthermore, the impact of miRNAs in neurocysticercosis, the brain infection caused by larvae ofis still unknown. Read More

    Fourth ventricle neurocysticercosis: Rigid endoscopic management. Description of direct transcerebellar approach.
    Surg Neurol Int 2017 26;8:232. Epub 2017 Sep 26.
    Neurosurgery Department, Centro Médico "Lic. Adolfo López Mateos", Instituto de Salud del Estado de México, Av. Nicolas San Juan s/n Ex Hacienda La Magdalena, Estado de México, México.
    Background: Endoscopy has gained a crucial role in high specialty neurosurgery during the last decades. At present, there are well-defined flexible neuroendoscopic procedures to treat ventricular and subarachnoid space pathologies. Neurocysticercosis is recognized as a common cause of neurologic disease in developing countries and the United States. Read More

    Antibody Banding Patterns of the Enzyme-Linked Immunoelectrotransfer Blot and Brain Imaging Findings in Patients With Neurocysticercosis.
    Clin Infect Dis 2018 Jan;66(2):282-288
    School of Public Health and Management, Universidad Peruana Cayetano Heredia, Lima, Peru.
    Background: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections in the central nervous system (CNS), and patients with a single viable brain cyst may be EITB negative. Nonetheless, EITB antibody banding patterns appears to be related with the expression of 3 protein families of Taenia solium, and in turn with the characteristics of NCC in the CNS (type, stage, and burden of viable cysts). Read More

    Taenia crassiceps antigens induce a Th2 immune response and attenuate injuries experimentally induced by neurotoxoplasmosis in BALB/c mice.
    Parasitol Int 2018 Feb 5;67(1):16-22. Epub 2017 Oct 5.
    Department of Microbiology, Immunology, Parasitology and Pathology, Tropical Pathology and Public Health Institute, Federal University of Goias, Rua 235 S/N, Setor Universitário, 74605-050 Goiânia, Goiás, Brazil. Electronic address:
    Toxoplasma gondii is a pathogenic agent responsible for causing both systemic and local disease which elicits a typically pro-inflammatory, Th1 immune response. Taenia crassiceps antigen induces a Th2 immune response that immunomodulates Th1 based infections. Therefore the aim of this study was to evaluate whether T. Read More

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