1,985 results match your criteria Neurocritical Care[Journal]


Stomaching Acute Brain Injury.

Neurocrit Care 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Gastrointestinal complications, including hemorrhage, can occur with intracranial lesions and after craniotomy. As early as the 19th century, surgeons were aware that brain tumors could cause gastric ulcers and acute perforations. Investigators used animal experiments both to reproduce these clinical observations and to seek ways to block the effects. Read More

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http://dx.doi.org/10.1007/s12028-019-00685-9DOI Listing
February 2019

The Origin of Intracranial Pressure Causing Brainstem Hemorrhages.

Neurocrit Care 2019 Feb 15. Epub 2019 Feb 15.

Division of Neurocritical Care and Hospital Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

The origin of secondary brainstem hemorrhages following an acute expansive hemispheric lesion has been attributed to Henri Duret, who proposed that hemorrhaging was caused by a shock wave through the cerebral spinal fluid. However, other experiments have shown important findings correlating brainstem hemorrhages to arterial hemorrhages. Animal studies found that the rapidity of expansion of a lesion would be crucial in producing these lesions, but there was no consistent correlation with paratentorial grooving so commonly seen with increased intracranial pressure. Read More

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http://dx.doi.org/10.1007/s12028-019-00688-6DOI Listing
February 2019

Perioperative Treatment of Brain Arteriovenous Malformations Between 2006 and 2014: The Helsinki Protocol.

Neurocrit Care 2019 Feb 14. Epub 2019 Feb 14.

Division of Anesthesiology, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objective: We reviewed retrospectively the perioperative treatment of microsurgically resected brain arteriovenous malformations (bAVMs) at the neurosurgical department of Helsinki University Hospital between the years 2006 and 2014. We examined the performance of the treatment protocol and the incidence of delayed postoperative hemorrhage (DPH).

Methods: The Helsinki protocol for postoperative treatment of bAVMs was used for the whole patient cohort of 121. Read More

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http://dx.doi.org/10.1007/s12028-019-00674-yDOI Listing
February 2019

Noeud Vital and the Respiratory Centers.

Neurocrit Care 2019 Feb 14. Epub 2019 Feb 14.

Mayo Clinic Division of Neurocritical Care and Hospital Neurology, 200 First Street SW, Rochester, MN, 55905, USA.

We now recognize that the main breathing generator resides principally in the medulla oblongata. Vivisectionists-specifically, Julien Legallois-discovered "the respiratory center." Cutting through the brainstem stops respiration but not if the medulla remains intact and the brain is sliced in successive portions. Read More

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http://dx.doi.org/10.1007/s12028-019-00686-8DOI Listing
February 2019

Physician Experiences with Communicating Organ Donation with the Relatives: A Dutch Nationwide Evaluation on Factors that Influence Consent Rates.

Neurocrit Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Intensive Care Medicine, Radboud University Medical Center, P.O. Box 9101, Internal Post 710, 6500 HB, Nijmegen, The Netherlands.

Background: The aim of this nationwide observational study is to identify modifiable factors in communication about organ donation that influence family consent rates.

Methods: Thirty-two intensivists specialized in organ donation systematically evaluated all consecutive organ donation requests with physicians in the Netherlands between January 2013 and June 2016, using a standardized questionnaire.

Results: Out of 2528 consecutive donation requests, 2095 (83%) were evaluated with physicians. Read More

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http://dx.doi.org/10.1007/s12028-019-00678-8DOI Listing
February 2019

Admission Heart Rate Variability is Associated with Fever Development in Patients with Intracerebral Hemorrhage.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurology, Northwestern University, Chicago, USA.

Background: Fever is associated with worse outcome after intracerebral hemorrhage (ICH). Autonomic dysfunction, commonly seen after brain injury, results in reduced heart rate variability (HRV). We sought to investigate whether HRV was associated with the development of fever in patients with ICH. Read More

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http://dx.doi.org/10.1007/s12028-019-00684-wDOI Listing
February 2019

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
February 2019

Hematoma Expansion Differences in Lobar and Deep Primary Intracerebral Hemorrhage.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Background: Hematoma expansion (HE) after intracerebral hemorrhage (ICH) is associated with worse outcome. Lobar ICHs are known to have better outcomes compared to deep ICH; however, it is unclear whether there are HE differences between these locations. We sought to investigate the hypothesis that lobar ICH has less HE compared to deep ICH. Read More

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http://dx.doi.org/10.1007/s12028-018-00668-2DOI Listing
February 2019

Author's Response to Letter to the Editor: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, University of Michigan, 3552 Taubman Health Care Center, SPC 5338, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5338, USA.

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http://dx.doi.org/10.1007/s12028-019-00681-zDOI Listing
February 2019

Intracranial Pressure Evaluation in Acute Liver Failure.

Neurocrit Care 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081, Baronissi, Salerno, Italy.

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http://dx.doi.org/10.1007/s12028-019-00680-0DOI Listing
February 2019
1 Read

Paroxysmal Sympathetic Hyperactivity with Dystonia Following Non-traumatic Bilateral Thalamic and Cerebellar Hemorrhage.

Neurocrit Care 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, University of Miami Miller School of Medicine, 1120 NW 14th Street, 13th Floor, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s12028-019-00677-9DOI Listing
February 2019
1 Read

Incidence of Arterial Hypotension in Patients Receiving Peroral or Continuous Intra-arterial Nimodipine After Aneurysmal or Perimesencephalic Subarachnoid Hemorrhage.

Neurocrit Care 2019 Feb 6. Epub 2019 Feb 6.

Department of Anesthesiology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Background: Oral nimodipine is used for prophylaxis and treatment of delayed cerebral ischemia in patients with aneurysmal or perimesencephalic subarachnoid hemorrhage (SAH). In cases of serious refractory cerebral vasospasm, a continuous intra-arterial (IA) infusion of nimodipine (CIAN) may be required to avoid cerebral ischemia. Nimodipine can cause arterial hypotension requiring either a dosage reduction or its discontinuation. Read More

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http://dx.doi.org/10.1007/s12028-019-00676-wDOI Listing
February 2019
1 Read

Functional Coagulation Differences Between Lobar and Deep Intracerebral Hemorrhage Detected by Rotational Thromboelastometry: A Pilot Study.

Neurocrit Care 2019 Jan 28. Epub 2019 Jan 28.

Vagelos College of Physicians and Surgeons, Columbia University, 177 Fort Washington Ave, New York, NY, 10032, USA.

Background: Lobar intracerebral hemorrhage (ICH) is known to have better clinical outcomes and preliminary evidence of less hematoma expansion compared to deep ICH. No functional coagulation differences between lobar and deep ICH have been identified using traditional plasma-based coagulation tests. We investigated for coagulation differences between lobar and deep ICH using whole-blood coagulation testing (Rotational Thromboelastometry: [ROTEM]). Read More

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http://dx.doi.org/10.1007/s12028-019-00672-0DOI Listing
January 2019

Clinical and Radiological Characteristics of Vitamin K Versus Non-Vitamin K Antagonist Oral Anticoagulation-Related Intracerebral Hemorrhage.

Neurocrit Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

Background/objective: Recent studies indicated that functional outcome after intracranial hemorrhage (ICH) related to direct oral anticoagulation (DOAC-ICH) is similar, if not better, than vitamin K antagonist (VKA)-related ICH (VKA-ICH) due to a smaller initial hematoma volume (HV). However, the association with hematoma expansion (HE) and location is not well understood.

Methods: We retrospectively analyzed 102 consecutive patients with acute non-traumatic ICH on oral anticoagulation therapy to determine HV and HE stratified by hematoma location, and the relation to the 90-day outcome. Read More

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http://link.springer.com/10.1007/s12028-019-00671-1
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http://dx.doi.org/10.1007/s12028-019-00671-1DOI Listing
January 2019
4 Reads
2.440 Impact Factor

Venous and arterial TNF-R1 predicts outcome and complications in acute subarachnoid hemorrhage.

Neurocrit Care 2019 Jan 23. Epub 2019 Jan 23.

Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.

Background: There is increasing evidence for the role of inflammation in clinical outcome after subarachnoid hemorrhage (SAH). Specifically, the TNF-alfa(α) pathway seems to be relevant after SAH. Although the TNF-α main receptor, TNF-R1 is associated with aneurysm growth and rupture, its relation to prognosis is unknown. Read More

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http://dx.doi.org/10.1007/s12028-019-00669-9DOI Listing
January 2019

Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental-Clinical Disconnect and the Unmet Need.

Neurocrit Care 2019 Jan 22. Epub 2019 Jan 22.

Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

Background: Delayed cerebral ischemia (DCI) is among the most dreaded complications following aneurysmal subarachnoid hemorrhage (SAH). Despite advances in neurocritical care, DCI remains a significant cause of morbidity and mortality, prolonged intensive care unit and hospital stay, and high healthcare costs. Large artery vasospasm has classically been thought to lead to DCI. Read More

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http://dx.doi.org/10.1007/s12028-018-0650-5DOI Listing
January 2019
13 Reads

The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy-A Matched Pair Analysis.

Neurocrit Care 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background And Purpose: Although the treatment window for mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) has been extended in recent years, it has been proven that recanalizing treatment must be administered as soon as possible. We present a new standard operating procedure (SOP) to reduce in-house delay, standardize periinterventional management and improve patient safety during MT.

Methods: KEep Evaluating Protocol Simplification In Managing Periinterventional Light Sedation for Endovascular Stroke Treatment (KEEP SIMPLEST) was a prospective, single-center observational study aimed to compare aspects of periinterventional management in AIS patients treated according to our new SOP using a combination of esketamine and propofol with patients having been randomized into conscious sedation (CS) in the Sedation versus Intubation for Endovascular Stroke TreAtment (SIESTA) trial. Read More

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http://dx.doi.org/10.1007/s12028-018-00667-3DOI Listing
January 2019
1 Read

Safety and Feasibility of Early Mobilization in Patients with Subarachnoid Hemorrhage and External Ventricular Drain.

Neurocrit Care 2019 Jan 18. Epub 2019 Jan 18.

University of Pennsylvania, Philadelphia, USA.

Background/objective: In November 2014, our Neurointensive Care Unit began a multi-phased progressive early mobilization initiative for patients with subarachnoid hemorrhage and an external ventricular drain (EVD). Our goal was to transition from a culture of complete bed rest (Phase 0) to a physical and occupational therapy (PT/OT)-guided mobilization protocol (Phase I), and ultimately to a nurse-driven mobilization protocol (Phase II). We hypothesized that nurses could mobilize patients as safely as an exclusively PT/OT-guided approach. Read More

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http://dx.doi.org/10.1007/s12028-019-00670-2DOI Listing
January 2019
1 Read

Response to "Letter to the Editor" by Couret et al.

Authors:
Charlene Ong

Neurocrit Care 2019 Jan 14. Epub 2019 Jan 14.

Division of Neurocritical Care, Department of Neurology, Boston University School of Medicine, Boston, USA.

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http://dx.doi.org/10.1007/s12028-018-0665-yDOI Listing
January 2019

Stroke Risk Following Infection in Patients with Continuous-Flow Left Ventricular Assist Device.

Neurocrit Care 2019 Jan 14. Epub 2019 Jan 14.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: Infection has been associated with stroke in patients with left ventricular assist devices (LVAD); however, little data exist on the timing, type and mortality impact of infection-related stroke.

Methods: Prospectively collected data of HeartMate II (N = 332) and HeartWare (N = 70) LVAD patients from a single center were reviewed. Only strokes (ischemic or hemorrhagic) that occurred within 6 weeks following a LVAD infection were considered in analyses. Read More

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http://dx.doi.org/10.1007/s12028-018-0662-1DOI Listing
January 2019

Daptomycin Plasma and CSF Levels in Patients with Healthcare-Associated Meningitis.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, Turin, Italy.

Background: There are currently few data concerning the cerebrospinal fluid (CSF) penetration of daptomycin in patients with healthcare-associated meningitis. This study aims (1) to better characterize the pharmacokinetics of daptomycin in humans during a 7-day intravenous (IV) therapy course, and (2) to study the penetration of daptomycin in the CSF after IV infusion at the dose of 10 mg/kg.

Results: In this prospective observational study, we enrolled nine patients with an implanted external ventricular drainage and a diagnosis of a healthcare-associated meningitis. Read More

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http://dx.doi.org/10.1007/s12028-018-0657-yDOI Listing
January 2019

Experience in Rehabilitation Medicine Affects Prognosis and End-of-Life Decision-Making of Neurologists: A Case-Based Survey.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Institute for History and Ethics in Medicine, Technical University Munich, Munich, Germany.

Background: Outcome predictions in patients with acute severe neurologic disorders are difficult and influenced by multiple factors. Since the decision for and the extent of life-sustaining therapies are based on the estimated prognosis, it is vital to understand which factors influence such estimates. This study examined whether previous professional experience with rehabilitation medicine influences physician decision-making. Read More

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http://dx.doi.org/10.1007/s12028-018-0661-2DOI Listing
January 2019

Epidemiology-Based Mortality Score is Associated with Long-Term Mortality after Status Epilepticus.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurology, University Hospital of Odense, Sdr. Boulevard 10, 5000, Odense C, Denmark.

Background/objective: Status epilepticus (SE) is a life-threatening condition with a high long-term mortality. The correct prediction of the individual patient's outcome is crucial for stratifying treatment. Status epilepticus severity score (STESS) and the epidemiology-based mortality score (EMSE) are well established for predicting in-hospital mortality; however, scores indicating long-term mortality are lacking. Read More

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http://dx.doi.org/10.1007/s12028-018-0663-0DOI Listing
January 2019

Systematic Review of Intrathecal Nicardipine for the Treatment of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.

Intrathecal nicardipine has been shown to have some efficacy for the treatment of symptomatic cerebral vasospasm in aneurysmal subarachnoid hemorrhage (aSAH). We performed a PRISMA-based systematic review of intrathecal nicardipine for the treatment of cerebral vasospasm in aneurysmal subarachnoid hemorrhage. A total of 825 articles were reviewed. Read More

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http://dx.doi.org/10.1007/s12028-018-0659-9DOI Listing
January 2019

The effect of ambient-light conditions on quantitative pupillometry: a history of rubber cup.

Neurocrit Care 2019 Jan 2. Epub 2019 Jan 2.

Department of Anesthesiology and Critical Care Medicine, University Hospital La Timone, Aix Marseille University, Marseille, France.

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http://link.springer.com/10.1007/s12028-018-0664-z
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http://dx.doi.org/10.1007/s12028-018-0664-zDOI Listing
January 2019
5 Reads

Decompressive Hemicraniectomy in Elderly Patients With Space-Occupying Infarction (DECAP): A Prospective Observational Study.

Neurocrit Care 2018 Dec 19. Epub 2018 Dec 19.

Medical Faculty, Technische Universität Dresden, Dresden, Germany.

Background: Decompressive hemicraniectomy improves survival rates and functional outcome in patients with space-occupying middle cerebral artery (MCA) infarction. We sought to determine clinical outcomes in elderly patients with MCA infarction treated with hemicraniectomy and to identify factors associated with functional outcome.

Methods: We performed a prospective, single-center observational study aiming to include patients aged ≥ 61 years with large MCA infarction treated with hemicraniectomy. Read More

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http://dx.doi.org/10.1007/s12028-018-0660-3DOI Listing
December 2018

Intracranial Hypertension After Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-analysis of Prevalence and Mortality Rate.

Neurocrit Care 2018 Dec 18. Epub 2018 Dec 18.

Kenneth Rainin Endowed Chair in Neurocritical Care, Professor of Neurology and Neurological Surgery, University of California, San Francisco, USA.

The objective of this study was to determine the prevalence of intracranial hypertension (IHT) and the associated mortality rate in patients who suffered from primary intracerebral hemorrhage (ICH). A secondary objective was to assess predisposing factors to IHT development. We conducted a systematic literature search of major electronic databases (MEDLINE, EMBASE, and Cochrane Library), for studies that assessed intracranial pressure (ICP) monitoring in patients with acute ICH. Read More

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http://link.springer.com/10.1007/s12028-018-0658-x
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http://dx.doi.org/10.1007/s12028-018-0658-xDOI Listing
December 2018
7 Reads

ABO Blood Type and Hematoma Expansion After Intracerebral Hemorrhage: An Exploratory Analysis.

Neurocrit Care 2018 Dec 13. Epub 2018 Dec 13.

Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Background/purpose: Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH).

Methods: Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia University Irving Medical Center from 2009 to 2016 were evaluated. Read More

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http://link.springer.com/10.1007/s12028-018-0655-0
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http://dx.doi.org/10.1007/s12028-018-0655-0DOI Listing
December 2018
14 Reads

Cerebral Vascular Changes During Acute Intracranial Pressure Drop.

Neurocrit Care 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiological Nursing, University of California, 2 Koret Way, San Francisco, CA, 94143, USA.

Objective: This study applied a new external ventricular catheter, which allows intracranial pressure (ICP) monitoring and cerebral spinal fluid (CSF) drainage simultaneously, to study cerebral vascular responses during acute CSF drainage.

Methods: Six patients with 34 external ventricular drain (EVD) opening sessions were retrospectively analyzed. A published algorithm was used to extract morphological features of ICP recordings, and a template-matching algorithm was applied to calculate the likelihood of cerebral vasodilation index (VDI) and cerebral vasoconstriction index (VCI) based on the changes of ICP waveforms during CSF drainage. Read More

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http://dx.doi.org/10.1007/s12028-018-0651-4DOI Listing
December 2018
1 Read

The Incidence of Meningitis in Patients with Traumatic Brain Injury Undergoing External Ventricular Drain Placement: A Nationwide Inpatient Sample Analysis.

Neurocrit Care 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.

Background/objective: Infection is the most common complication of external ventricular drain (EVD) placement. National trends in the annual incidence of meningitis among patients with traumatic brain injury (TBI) who have undergone EVD placement have not been reported.

Methods: The Nationwide Inpatient Sample was used to select adults with a primary diagnosis of TBI who underwent EVD placement between 2002 and 2011. Read More

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http://dx.doi.org/10.1007/s12028-018-0656-zDOI Listing
December 2018
1 Read

Surveillance Ultrasound in the Neuro Intensive Care Unit: Time to Deep Vein Thrombosis Diagnosis.

Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.

University Health System, San Antonio, TX, USA.

Background/objectives: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are complications of hospitalization leading to increased morbidity and mortality. Routine surveillance ultrasound has become common practice in some intensive care units (ICU) to detect DVT early and initiate anticoagulation, preventing complications. However, initiating anticoagulants for asymptomatic DVT treatment may increase risk of hemorrhage. Read More

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http://dx.doi.org/10.1007/s12028-018-0652-3DOI Listing
December 2018
1 Read

MRI Presentation of Infectious Intracranial Aneurysms in Infective Endocarditis.

Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: The radiographic appearance of infectious intracranial aneurysms (IIAs) of infective endocarditis (IE) on magnetic resonance imaging (MRI) of brain is varied. We aimed to describe the IIA-specific MRI features in a series of patients with IIAs.

Methods: Records of patients with active IE who had digital subtraction angiography (DSA) at a tertiary medical center from January 2011 to December 2016 were reviewed. Read More

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http://link.springer.com/10.1007/s12028-018-0654-1
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http://dx.doi.org/10.1007/s12028-018-0654-1DOI Listing
December 2018
10 Reads

Dispersion in Scores on the Richmond Agitation and Sedation Scale as a Measure of Delirium in Patients with Subdural Hematomas.

Neurocrit Care 2018 Nov 30. Epub 2018 Nov 30.

Division of Critical Care Neurology, Department of Neurology, Columbia University Medical Center, Milstein Hospital Building, 177 Fort Washington Avenue, 8-300 Center, New York, NY, 10032, USA.

Background: Delirium is a frequent complication of critical illness, but its diagnosis is more difficult in brain-injured patients due to language impairment and disorders of consciousness. We conducted a prospective cohort study to determine whether Richmond Agitation and Sedation Scale (RASS) scores could be used to reliably diagnose delirium in the setting of brain injury. We also examined clinical factors associated with delirium in patients with subdural hematomas (SDH) and assessed its impact on functional outcome at discharge. Read More

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http://dx.doi.org/10.1007/s12028-018-0649-yDOI Listing
November 2018
2 Reads

Evaluation of a New Catheter for Simultaneous Intracranial Pressure Monitoring and Cerebral Spinal Fluid Drainage: A Pilot Study.

Neurocrit Care 2018 Dec 3. Epub 2018 Dec 3.

Department of Physiological Nursing, University of California, 2 Koret Way, San Francisco, CA, 94143, USA.

Objectives: Intracranial pressure (ICP) monitoring is a common practice when treating intracranial pathology with risk of elevated ICP. External ventricular drain (EVD) insertion is a standard approach for both monitoring ICP and draining cerebrospinal fluid (CSF). However, the conventional EVD cannot serve these two purposes simultaneously because it cannot accurately measure ICP and its pulsatile waveform while the EVD is open to CSF drainage. Read More

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http://dx.doi.org/10.1007/s12028-018-0648-zDOI Listing
December 2018
1 Read

The Feasibility, Safety and Effectiveness of a Ketogenic Diet for Refractory Status Epilepticus in Adults in the Intensive Care Unit.

Neurocrit Care 2018 Nov 27. Epub 2018 Nov 27.

Epilepsy Center, Hauenstein Neurosciences Mercy Health Saint Mary's, Grand Rapids, MI, USA.

Background: Status, refractory status and super refractory status epilepticus are common neurologic emergencies. The objective of this study is to investigate the feasibility, safety and effectiveness of a ketogenic diet (KD) for refractory status epilepticus (RSE) in adults in the intensive care unit (ICU).

Methods: We performed a retrospective, single-center study of patients between ages 18 and 80 years with RSE treated with a KD treatment algorithm from November 2016 through April 2018. Read More

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http://dx.doi.org/10.1007/s12028-018-0653-2DOI Listing
November 2018
1 Read

Cardiac Dysfunction in Neurocritical Care: An Autonomic Perspective.

Neurocrit Care 2018 Nov 27. Epub 2018 Nov 27.

Department of Neurology, Division of Neurocritical care, Wayne State University School of Medicine, Detroit, MI, USA.

A number of neurologic disorders can cause cardiac dysfunction by involving the conductive system and contractile apparatus of the heart. This is especially prominent in the neurocritical care setting where the spectrum of cardiac dysfunction due to acute neurologic injury ranges from trivial and isolated electrocardiographic changes to malignant arrhythmias and sudden death (Table 1). The mechanism of these cardiac complications is complex and not fully understood. Read More

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http://dx.doi.org/10.1007/s12028-018-0636-3DOI Listing
November 2018
8 Reads

A Systematic Review Assessing the Current State of Automated Pupillometry in the NeuroICU.

Neurocrit Care 2018 Nov 27. Epub 2018 Nov 27.

Department of Ophthalmology, Emory University School of Medicine, 1648 Pierce Drive NE, Atlanta, GA, 30307, USA.

The aim of this study was to assess the current state of automated pupillometry technology and its application in the neurointensive care unit (neuroICU). We performed a literature search using the PubMed, MEDLINE, and EMBASE databases from database inception through a search end date of October 18, 2018, to identify studies reporting on the use of automated pupillometry in the care of critically ill patients with neurological impairment. Two independent reviewers reviewed all titles and abstracts in two filtering phases. Read More

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http://dx.doi.org/10.1007/s12028-018-0645-2DOI Listing
November 2018
3 Reads

Early Manipulation of Arterial Blood Pressure in Acute Ischemic Stroke (MAPAS): Results of a Randomized Controlled Trial.

Neurocrit Care 2018 Nov 20. Epub 2018 Nov 20.

The George Institute for Global Health, Royal Prince Alfred Hospital, University of New South Wales, Sydney, Australia.

Introduction: There is uncertainty over the optimal level of systolic blood pressure (SBP) in the setting of acute ischemic stroke (AIS). The aim of this study was to determine the efficacy of the early manipulation of SBP in non-thrombolised patients. The key hypothesis under investigation was that clinical outcomes vary across ranges of SBP in AIS. Read More

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http://dx.doi.org/10.1007/s12028-018-0642-5DOI Listing
November 2018
11 Reads

Current Practices of Intraventricular Antibiotic Therapy in the Treatment of Meningitis and Ventriculitis: Results from a Multicenter Retrospective Cohort Study.

Neurocrit Care 2018 Nov 16. Epub 2018 Nov 16.

Departments of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.

Background: Central nervous system (CNS) infections are particularly prevalent in the adult neurocritical care patient population and are associated with significant morbidity and mortality. Factors relevant to the nature of CNS infections pose significant challenges to clinicians treating afflicted patients. Intraventricular (IVT) administration of antibiotics may offer several benefits over systemic therapy; however, the outcomes and current practices of such treatments are poorly described in the literature. Read More

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http://link.springer.com/10.1007/s12028-018-0647-0
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http://dx.doi.org/10.1007/s12028-018-0647-0DOI Listing
November 2018
16 Reads

Thrombus "Squeezing" Through Patent Foramen Ovale After Traumatic Brain Injury.

Neurocrit Care 2018 Nov 16. Epub 2018 Nov 16.

Neuroscience Institute, The Queen's Medical Center, 1301 Punchbowl Street, Honolulu, HI, 96813, USA.

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http://link.springer.com/10.1007/s12028-018-0646-1
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http://dx.doi.org/10.1007/s12028-018-0646-1DOI Listing
November 2018
6 Reads

The Role of Glycerol-Containing Drugs in Cerebral Microdialysis: A Retrospective Study on the Effects of Intravenously Administered Glycerol.

Neurocrit Care 2018 Nov 14. Epub 2018 Nov 14.

Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: Cerebral microdialysis (CMD) is a valuable tool for monitoring compounds in the cerebral extracellular fluid (ECF). Glycerol is one such compound which is regarded as a marker of cell membrane decomposition. Notably, in some acutely brain-injured patients, CMD-glycerol levels rise without any other apparent indication of cerebral deterioration. Read More

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http://link.springer.com/10.1007/s12028-018-0643-4
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http://dx.doi.org/10.1007/s12028-018-0643-4DOI Listing
November 2018
8 Reads

Expansion-Prone Hematoma: Defining a Population at High Risk of Hematoma Growth and Poor Outcome.

Neurocrit Care 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: Noncontrast computed tomography (CT) markers are increasingly used for predicting hematoma expansion. The aim of our study was to investigate the predictive value of expansion-prone hematoma in predicting hematoma expansion and outcome in patients with intracerebral hemorrhage (ICH).

Methods: Between July 2011 and January 2017, ICH patients who underwent baseline CT scan within 6 h of symptoms onset and follow-up CT scan were recruited into the study. Read More

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http://link.springer.com/10.1007/s12028-018-0644-3
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http://dx.doi.org/10.1007/s12028-018-0644-3DOI Listing
November 2018
7 Reads

Assessment and Comparison of the Four Most Extensively Validated Prognostic Scales for Intracerebral Hemorrhage: Systematic Review with Meta-analysis.

Neurocrit Care 2018 Nov 13. Epub 2018 Nov 13.

Centre for Health Technology and Services Research and Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal.

Background/objective: Intracerebral hemorrhage (ICH) is a devastating disorder, responsible for 10% of all strokes. Several prognostic scores have been developed for this population to predict mortality and functional outcome. The aim of this study was to determine the four most frequently validated and most widely used scores, assess their discrimination for both outcomes by means of a systematic review with meta-analysis, and compare them using meta-regression. Read More

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http://link.springer.com/10.1007/s12028-018-0633-6
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http://dx.doi.org/10.1007/s12028-018-0633-6DOI Listing
November 2018
7 Reads

Preventing Chronic Emotional Distress in Stroke Survivors and Their Informal Caregivers.

Neurocrit Care 2018 Nov 12. Epub 2018 Nov 12.

Integrated Brain Health Clinical and Research Program, Department of Psychiatry, Harvard Medical School/Massachusetts General Hospital, One Bowdoin Square, 1st Floor, Boston, MA, 02114, USA.

Background/objective: Chronic emotional distress (e.g., depression, anxiety, post-traumatic stress) is common after stroke and interdependent between patients and their informal caregivers. Read More

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http://link.springer.com/10.1007/s12028-018-0641-6
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http://dx.doi.org/10.1007/s12028-018-0641-6DOI Listing
November 2018
16 Reads

The Full Outline of UnResponsiveness (FOUR) Score and Its Use in Outcome Prediction: A Scoping Systematic Review of the Adult Literature.

Neurocrit Care 2018 Nov 8. Epub 2018 Nov 8.

Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Background: The Full Outline of UnResponsivness (FOUR) score is a neurological assessment score. Its theoretical benefit over preexisting scores is its evaluation of brainstem reflexes and respiratory pattern which may allow better assessment of patients with severe neurologic impairment.

Objective: Our goal was to perform a scoping systematic review on the available literature for FOUR score and outcome prediction in critically ill patients. Read More

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http://link.springer.com/10.1007/s12028-018-0630-9
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http://dx.doi.org/10.1007/s12028-018-0630-9DOI Listing
November 2018
17 Reads

Intraosseous Administration of 23.4% NaCl for Treatment of Intracranial Hypertension.

Neurocrit Care 2018 Nov 5. Epub 2018 Nov 5.

Neuroscience Intensive Care Unit, Medical Critical Care Service, Department of Medicine, INOVA Fairfax Hospital, 3300 Gallows Rd, Falls Church, VA, 22042, USA.

Background/objective: Prompt treatment of acute intracranial hypertension is vital to preserving neurological function and frequently includes administration of 23.4% NaCl. However, 23. Read More

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http://link.springer.com/10.1007/s12028-018-0637-2
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http://dx.doi.org/10.1007/s12028-018-0637-2DOI Listing
November 2018
20 Reads

Inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs.

Neurocrit Care 2018 Nov 1. Epub 2018 Nov 1.

Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, JM3, Philadelphia, PA, l9l04, USA.

Objective: Traumatic brain injury (TBI) is an important contributor to morbidity and mortality. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Extracellular signal-related kinase (ERK) mitogen activated protein kinase (MAPK) and ET-1 are upregulated and contribute to impairment of cerebral autoregulation and histopathology after porcine fluid percussion brain injury (FPI). Read More

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http://dx.doi.org/10.1007/s12028-018-0638-1DOI Listing
November 2018

Spontaneous Hyperventilation in Severe Traumatic Brain Injury: Incidence and Association with Poor Neurological Outcome.

Neurocrit Care 2018 Nov 1. Epub 2018 Nov 1.

Intensive Care Unit, Sainte Anne Military Hospital, Toulon, France.

Background: Hypocapnia induces cerebral vasoconstriction leading to a decrease in cerebral blood flow, which might precipitate cerebral ischemia. Hypocapnia can be intentional to treat intracranial hypertension or unintentional due to a spontaneous hyperventilation (SHV). SHV is frequent after subarachnoid hemorrhage. Read More

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http://dx.doi.org/10.1007/s12028-018-0639-0DOI Listing
November 2018
2 Reads

Effect of Electrical Vagus Nerve Stimulation on Cerebral Blood Flow and Neurological Outcome in Asphyxial Cardiac Arrest Model of Rats.

Neurocrit Care 2018 Oct 31. Epub 2018 Oct 31.

Department of Emergency Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.

Background: Vagus nerve stimulation (VNS) during post-resuscitation may increase recovery of cerebral blood flow (CBF) and reduce neurological injury.

Objective: This study was designed to investigate the effect of electrical VNS on neurological outcomes following cardiac arrest (CA).

Methods: Male Sprague-Dawley rats (n = 48) were subjected to the asphyxial CA model and blindly allocated to the VN isolation (CA + VN isolation) or VNS group (CA + VNS group). Read More

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http://link.springer.com/10.1007/s12028-018-0640-7
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http://dx.doi.org/10.1007/s12028-018-0640-7DOI Listing
October 2018
3 Reads

Management of Patients with Acute Subdural Hemorrhage During Treatment with Direct Oral Anticoagulants.

Neurocrit Care 2018 Oct 31. Epub 2018 Oct 31.

Department of Neurosurgery, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Anticoagulation therapy is a major risk factor for unfavorable patient outcomes following (traumatic) intracranial hemorrhage. Direct oral anticoagulants (DOAC) are increasingly used for the prevention and treatment of thromboembolic diseases. Data on patients treated for acute subdural hemorrhage (SDH) during anticoagulation therapy with DOAC are limited. Read More

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http://link.springer.com/10.1007/s12028-018-0635-4
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http://dx.doi.org/10.1007/s12028-018-0635-4DOI Listing
October 2018
5 Reads