2,011 results match your criteria Neurocritical Care[Journal]


Bedside Cranial Ultrasonography in Patients with Hemicraniectomies: A Novel Window into Pathology.

Neurocrit Care 2019 Apr 11. Epub 2019 Apr 11.

Division of Neurocritical Care, Department of Neurology and Rehabilitation, University of Cincinnati Medical Center, University of Cincinnati, 231 Albert Sabin Way, ML 0769, Cincinnati, OH, 45267-0769, USA.

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http://dx.doi.org/10.1007/s12028-019-00709-4DOI Listing

Neurostereologic Lesion Volumes and Spreading Depolarizations in Severe Traumatic Brain Injury Patients: A Pilot Study.

Neurocrit Care 2019 Apr 9. Epub 2019 Apr 9.

Department of Neurosurgery, University of Cincinnati (UC) College of Medicine, and UC Gardner Neuroscience Institute, Cincinnati, OH, USA.

Background: Spreading depolarizations (SDs) occur in 50-60% of patients after surgical treatment of severe traumatic brain injury (TBI) and are independently associated with unfavorable outcomes. Here we performed a pilot study to examine the relationship between SDs and various types of intracranial lesions, progression of parenchymal damage, and outcomes.

Methods: In a multicenter study, fifty patients (76% male; median age 40) were monitored for SD by continuous electrocorticography (ECoG; median duration 79 h) following surgical treatment of severe TBI. Read More

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http://dx.doi.org/10.1007/s12028-019-00692-wDOI Listing
April 2019
1 Read

Tracheostomy After Severe Acute Brain Injury: Trends and Variability in the USA.

Neurocrit Care 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurology, University of Washington, Seattle, USA.

Background/objective: Severe acute brain injury (SABI) is responsible for 12 million deaths annually, prolonged disability in survivors, and substantial resource utilization. Little guidance exists regarding indication or optimal timing of tracheostomy after SABI. Our aims were to determine national trends in tracheostomy utilization among mechanically ventilated patients with SABI in the USA, as well as to examine factors associated with tracheostomy utilization following SABI. Read More

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http://dx.doi.org/10.1007/s12028-019-00697-5DOI Listing
March 2019
1 Read

Feasibility and Safety of Transnasal High Flow Air to Reduce Core Body Temperature in Febrile Neurocritical Care Patients: A Pilot Study.

Neurocrit Care 2019 Mar 27. Epub 2019 Mar 27.

Department of Anesthesiology-Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Fever is an important determinant of prognosis following acute brain injury. Current non-pharmacologic techniques to reduce fever are limited and induce a shivering response. We investigated the safety and efficacy of a novel transnasal unidirectional high flow air device in reducing core body temperature in the neurocritical care unit (NCCU) setting. Read More

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http://dx.doi.org/10.1007/s12028-019-00702-xDOI Listing
March 2019
1 Read

Safety and Tolerability of Rapid Administration Undiluted Levetiracetam.

Neurocrit Care 2019 Mar 27. Epub 2019 Mar 27.

Department of Pharmacy and Drug Information, Grady Health Systems, Atlanta, GA, 30303, USA.

Background/objective: Levetiracetam (LEV) is an antiepileptic drug used widely in patients with a favorable safety profile. Studies evaluating the safety and efficacy of intravenous (IV) LEV included volumes of at least 100 mL. Minimally diluted doses administered over 5-6 min were found to be both safe and effective. Read More

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http://link.springer.com/10.1007/s12028-019-00708-5
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http://dx.doi.org/10.1007/s12028-019-00708-5DOI Listing
March 2019
3 Reads

Cooling via Trans-nasal High Flow Ambient Air: Does it Pass the Smell Test?

Neurocrit Care 2019 Mar 22. Epub 2019 Mar 22.

Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, John G. Rangos Research Center, 6th Floor, 4401 Penn Avenue, Pittsburgh, PA, 15224, USA.

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http://link.springer.com/10.1007/s12028-019-00701-y
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http://dx.doi.org/10.1007/s12028-019-00701-yDOI Listing
March 2019
3 Reads

Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium.

Neurocrit Care 2019 Mar 19. Epub 2019 Mar 19.

Department of Clinical Neurophysiology, The Neuroscience Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Delirium is common during sepsis, although under-recognized. We aimed to assess the value of continuous electroencephalography (cEEG) to aid in the diagnosis of delirium in septic patients.

Methods: We prospectively evaluated 102 consecutive patients in a medical intensive care unit (ICU), who had sepsis or septic shock, without evidence of acute primary central nervous system disease. Read More

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http://dx.doi.org/10.1007/s12028-019-00703-wDOI Listing
March 2019
7 Reads

Perampanel Treatment for Refractory Status Epilepticus in a Neurological Intensive Care Unit.

Neurocrit Care 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, 123, Dapi Road, Niaosung District, Kaohsiung, 83301, Taiwan.

Background/objective: Perampanel is a novel anti-epileptic drug (AED) which acts as a non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist to reduce glutamate-mediated postsynaptic excitation. Previous animal studies and a few case reports/series have suggested that it may be effective to treat refractory status epilepticus (RSE).

Methods: We retrospectively reviewed 67 consecutive patients with RSE, of whom 22 received perampanel. Read More

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http://dx.doi.org/10.1007/s12028-019-00704-9DOI Listing

Tracheostomy Practices in Neurocritical Care.

Authors:
David B Seder

Neurocrit Care 2019 Mar 19. Epub 2019 Mar 19.

Department of Critical Care Services, Maine Medical Center, Tufts University School of Medicine, 22 Bramhall St., Portland, ME, 04102, USA.

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http://dx.doi.org/10.1007/s12028-019-00706-7DOI Listing
March 2019
1 Read

Clinical Determination of Brain Death in Children Supported by Extracorporeal Membrane Oxygenation.

Neurocrit Care 2019 Mar 19. Epub 2019 Mar 19.

Division of Neurology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA.

Background/objective: Children supported by extracorporeal membrane oxygenation (ECMO) are at risk of catastrophic neurologic injury and brain death. Timely determination of brain death is important for minimizing psychological distress for families, resource allocation, and organ donation. Reports of successful determination of brain death in pediatric patients supported by ECMO are limited. Read More

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http://dx.doi.org/10.1007/s12028-019-00700-zDOI Listing
March 2019
1 Read

Propofol/Remifentanil Anesthesia Might Not Alter the Middle Cerebral Artery Diameter by Digital Subtraction Angiography.

Neurocrit Care 2019 Mar 14. Epub 2019 Mar 14.

Department of Anesthesia, Critical Care and Burn Unit, Hôpitaux Universitaires Saint Louis - Lariboisière, Assistance Publique - Hôpitaux de Paris, 2, rue Ambroise Paré, 75010, Paris, France.

Introduction: Transcranial Doppler (TCD) of the middle cerebral artery (MCA) enables the measurement of the mean blood velocity (MCA) and the estimation of the cerebral blood flow (CBF), provided that no significant changes occur in the MCA diameter (MCA). Previous studies described a decrease in the MCA associated with the induction of total intravenous anesthesia (TIVA) by propofol and remifentanil. This decrease in blood velocity might be interpreted as a decrease in the CBF only where the MCA is not modified across TCD examinations. Read More

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http://dx.doi.org/10.1007/s12028-019-00699-3DOI Listing

Pathophysiological Insights into Spreading Depolarization in Severe Traumatic Brain Injury.

Neurocrit Care 2019 Mar 15. Epub 2019 Mar 15.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s12028-019-00705-8DOI Listing

And the Beat Goes on…Heart Rate Variability After Spontaneous Intracranial Hemorrhage.

Neurocrit Care 2019 Apr;30(2):251-252

University of Miami, Miller School of Medicine, Miami, USA.

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http://dx.doi.org/10.1007/s12028-019-00696-6DOI Listing
April 2019
1 Read

Commentary on "Temporal Dynamics of Cerebral Blood Flow During the Acute Course of Severe Subarachnoid Hemorrhage Studied by Bedside Xenon-Enhanced CT".

Authors:
Rajat Dhar

Neurocrit Care 2019 Apr;30(2):291-292

Department of Neurology (Division of Neurocritical Care), Washington University in Saint Louis, 660 S Euclid Avenue, Campus Box 8111, Saint Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s12028-019-00698-4DOI Listing
April 2019
1 Read

Lundberg and his Waves.

Neurocrit Care 2019 Feb 25. Epub 2019 Feb 25.

Division of Neurocritical Care and Hospital Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

This historical vignette revisits the main contributions by Nils Lundberg, a neurosurgeon, that were published in the late 1950s and early 1960s. The Lundberg studies also definitively established that symptoms of abnormal brainstem function resulted from abnormal intracranial pressure (ICP), and moreover, even variations in ICP could produce clinical symptoms. The most innovative result of continuous monitoring was the discovery of plateau-shaped waves that produced paradoxical symptoms previously designated as "decerebrate" and "tonic fits" or "acute coning. Read More

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http://dx.doi.org/10.1007/s12028-019-00689-5DOI Listing
February 2019
1 Read

Multimodal Regional Brain Monitoring of Tissue Ischemia in Severe Cerebral Venous Sinus Thrombosis.

Neurocrit Care 2019 Feb 25. Epub 2019 Feb 25.

Department of Intensive Care Medicine, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Background: Comatose critically ill patients with severe diffuse cerebral venous thrombosis (CVT) are at high risk of secondary hypoxic/ischemic insults, which may considerably worsen neurological recovery. Multimodal brain monitoring (MBM) may therefore improve patient care in this setting, yet no data are available in the literature.

Methods: We report two patients with coma following severe diffuse CVT who underwent emergent invasive MBM with intracranial pressure (ICP), brain tissue oximetry (PbtO), and cerebral microdialysis (CMD). Read More

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http://dx.doi.org/10.1007/s12028-019-00695-7DOI Listing
February 2019
1 Read

The Ascending Reticular Activating System.

Neurocrit Care 2019 Feb 22. Epub 2019 Feb 22.

Division of Neurocritical Care and Hospital Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Discovery of the ascending reticular activating system (ARAS) can be attributed to work done in research neuroscientist Horace Magoun's laboratory. Before this finding, most scientists would focus on the diencephalon (and anterior midbrain) but not more caudally. Stimulation of the medial bulbar reticular formation in the pontine and midbrain tegmentum resulted disappearance of synchronized discharge and low-voltage fast activity. Read More

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http://dx.doi.org/10.1007/s12028-019-00687-7DOI Listing
February 2019
1 Read

Temporal Dynamics of Cerebral Blood Flow During the Acute Course of Severe Subarachnoid Hemorrhage Studied by Bedside Xenon-Enhanced CT.

Neurocrit Care 2019 Apr;30(2):280-290

Department of Neuroscience/Neurosurgery, Uppsala University, Uppsala, Sweden.

Background: Compromised cerebral blood flow (CBF) is a crucial factor in delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Repeated measurement of CBF may improve our understanding of the temporal dynamics following SAH. The aim of this study was to assess CBF at different phases of the acute course in poor-grade SAH patients, hypothesizing more pronounced disturbances at day 4-7, and that the initial level of CBF determines the following course of CBF. Read More

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http://dx.doi.org/10.1007/s12028-019-00675-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420446PMC
April 2019
2 Reads

Practice Variation in the Diagnosis of Aneurysmal Subarachnoid Hemorrhage: A Survey of US and Canadian Emergency Medicine Physicians.

Neurocrit Care 2019 Feb 21. Epub 2019 Feb 21.

Department of Emergency Medicine, Stanford University Medical Center, Palo Alto, USA.

Background And Aims: Spontaneous subarachnoid hemorrhage (SAH) from a brain aneurysm, if untreated in the acute phase, leads to loss of functional independence in about 30% of patients and death in 27-44%. To evaluate for SAH, the American College of Emergency Physicians (ACEP) Clinical Policy recommends obtaining a non-contrast brain computed tomography (CT) scan followed by a lumbar puncture (LP) if the CT is negative. On the other hand, current evidence from prospectively collected data suggests that CT alone may be sufficient to rule out SAH in patients who present within 6 h of symptom onset while anecdotal evidence suggests that CT angiogram (CTA) may be used to detect aneurysms, which are the probable cause of SAH. Read More

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http://dx.doi.org/10.1007/s12028-019-00679-7DOI Listing
February 2019
2 Reads

Asymptomatic Brain Abscess with Intracerebral Hemorrhage.

Neurocrit Care 2019 Feb 20. Epub 2019 Feb 20.

Department of Neurology, Research Institute of Clinical Medicine, School of Medicine, Chonbuk National University, Jeonju, South Korea.

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http://dx.doi.org/10.1007/s12028-019-00690-yDOI Listing
February 2019
1 Read
2.440 Impact Factor

Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome.

Neurocrit Care 2019 Feb 20. Epub 2019 Feb 20.

University of Cincinnati, Cincinnati, OH, USA.

Background: Abnormal restricted diffusion on magnetic resonance imaging is often associated with ischemic stroke or anoxic injury, but other conditions can present similarly. We present six cases of an unusual but consistent pattern of restricted diffusion in bilateral hippocampi and cerebellar cortices. This pattern of injury is distinct from typical imaging findings in ischemic, anoxic, or toxic injury, suggesting it may represent an under-recognized clinicoradiographic syndrome. Read More

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http://dx.doi.org/10.1007/s12028-018-00666-4DOI Listing
February 2019
2 Reads

A Trial of Real-Time Electrographic Seizure Detection by Neuro-ICU Nurses Using a Panel of Quantitative EEG Trends.

Neurocrit Care 2019 Feb 20. Epub 2019 Feb 20.

Department of Neurology, Duke University Medical Center, DUMC 2905, Durham, NC, 27710, USA.

Background: Non-convulsive seizures (NCS) are a common occurrence in the neurologic intensive care unit (Neuro-ICU) and are associated with worse outcomes. Continuous electroencephalogram (cEEG) monitoring is necessary for the detection of NCS; however, delays in interpretation are a barrier to early treatment. Quantitative EEG (qEEG) calculates a time-compressed simplified visual display from raw EEG data. Read More

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http://dx.doi.org/10.1007/s12028-019-00673-zDOI Listing
February 2019
1 Read

Quantitative Continuous EEG: Bridging the Gap Between the ICU Bedside and the EEG Interpreter.

Neurocrit Care 2019 Feb 20. Epub 2019 Feb 20.

Departments of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.

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http://dx.doi.org/10.1007/s12028-019-00694-8DOI Listing
February 2019
1 Read

Downstream Dislocation of a Ventriculo-Atrial Shunt Catheter.

Neurocrit Care 2019 Feb 20. Epub 2019 Feb 20.

Department of Neurology, Goethe University, Schleusenweg 2-17, 60528, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s12028-019-00691-xDOI Listing
February 2019
1 Read

Stomaching Acute Brain Injury.

Neurocrit Care 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Gastrointestinal complications, including hemorrhage, can occur with intracranial lesions and after craniotomy. As early as the 19th century, surgeons were aware that brain tumors could cause gastric ulcers and acute perforations. Investigators used animal experiments both to reproduce these clinical observations and to seek ways to block the effects. Read More

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http://dx.doi.org/10.1007/s12028-019-00685-9DOI Listing
February 2019
1 Read

The Origin of Intracranial Pressure Causing Brainstem Hemorrhages.

Neurocrit Care 2019 Feb 15. Epub 2019 Feb 15.

Division of Neurocritical Care and Hospital Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

The origin of secondary brainstem hemorrhages following an acute expansive hemispheric lesion has been attributed to Henri Duret, who proposed that hemorrhaging was caused by a shock wave through the cerebral spinal fluid. However, other experiments have shown important findings correlating brainstem hemorrhages to arterial hemorrhages. Animal studies found that the rapidity of expansion of a lesion would be crucial in producing these lesions, but there was no consistent correlation with paratentorial grooving so commonly seen with increased intracranial pressure. Read More

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http://dx.doi.org/10.1007/s12028-019-00688-6DOI Listing
February 2019
4 Reads

Perioperative Treatment of Brain Arteriovenous Malformations Between 2006 and 2014: The Helsinki Protocol.

Neurocrit Care 2019 Feb 14. Epub 2019 Feb 14.

Division of Anesthesiology, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objective: We reviewed retrospectively the perioperative treatment of microsurgically resected brain arteriovenous malformations (bAVMs) at the neurosurgical department of Helsinki University Hospital between the years 2006 and 2014. We examined the performance of the treatment protocol and the incidence of delayed postoperative hemorrhage (DPH).

Methods: The Helsinki protocol for postoperative treatment of bAVMs was used for the whole patient cohort of 121. Read More

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http://dx.doi.org/10.1007/s12028-019-00674-yDOI Listing
February 2019
1 Read

Noeud Vital and the Respiratory Centers.

Neurocrit Care 2019 Feb 14. Epub 2019 Feb 14.

Mayo Clinic Division of Neurocritical Care and Hospital Neurology, 200 First Street SW, Rochester, MN, 55905, USA.

We now recognize that the main breathing generator resides principally in the medulla oblongata. Vivisectionists-specifically, Julien Legallois-discovered "the respiratory center." Cutting through the brainstem stops respiration but not if the medulla remains intact and the brain is sliced in successive portions. Read More

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http://dx.doi.org/10.1007/s12028-019-00686-8DOI Listing
February 2019
1 Read

Physician Experiences with Communicating Organ Donation with the Relatives: A Dutch Nationwide Evaluation on Factors that Influence Consent Rates.

Neurocrit Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Intensive Care Medicine, Radboud University Medical Center, P.O. Box 9101, Internal Post 710, 6500 HB, Nijmegen, The Netherlands.

Background: The aim of this nationwide observational study is to identify modifiable factors in communication about organ donation that influence family consent rates.

Methods: Thirty-two intensivists specialized in organ donation systematically evaluated all consecutive organ donation requests with physicians in the Netherlands between January 2013 and June 2016, using a standardized questionnaire.

Results: Out of 2528 consecutive donation requests, 2095 (83%) were evaluated with physicians. Read More

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http://dx.doi.org/10.1007/s12028-019-00678-8DOI Listing
February 2019
1 Read

Admission Heart Rate Variability is Associated with Fever Development in Patients with Intracerebral Hemorrhage.

Neurocrit Care 2019 Apr;30(2):244-250

Department of Neurology, Northwestern University, Chicago, USA.

Background: Fever is associated with worse outcome after intracerebral hemorrhage (ICH). Autonomic dysfunction, commonly seen after brain injury, results in reduced heart rate variability (HRV). We sought to investigate whether HRV was associated with the development of fever in patients with ICH. Read More

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http://dx.doi.org/10.1007/s12028-019-00684-wDOI Listing
April 2019
2 Reads

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
February 2019
1 Read
2.440 Impact Factor

Hematoma Expansion Differences in Lobar and Deep Primary Intracerebral Hemorrhage.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Background: Hematoma expansion (HE) after intracerebral hemorrhage (ICH) is associated with worse outcome. Lobar ICHs are known to have better outcomes compared to deep ICH; however, it is unclear whether there are HE differences between these locations. We sought to investigate the hypothesis that lobar ICH has less HE compared to deep ICH. Read More

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http://dx.doi.org/10.1007/s12028-018-00668-2DOI Listing
February 2019
3 Reads

Author's Response to Letter to the Editor: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure.

Neurocrit Care 2019 Apr;30(2):497

Department of Neurosurgery, University of Michigan, 3552 Taubman Health Care Center, SPC 5338, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5338, USA.

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http://dx.doi.org/10.1007/s12028-019-00681-zDOI Listing
April 2019
3 Reads

Intracranial Pressure Evaluation in Acute Liver Failure.

Neurocrit Care 2019 Apr;30(2):495-496

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081, Baronissi, Salerno, Italy.

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http://dx.doi.org/10.1007/s12028-019-00680-0DOI Listing
April 2019
1 Read

Paroxysmal Sympathetic Hyperactivity with Dystonia Following Non-traumatic Bilateral Thalamic and Cerebellar Hemorrhage.

Neurocrit Care 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, University of Miami Miller School of Medicine, 1120 NW 14th Street, 13th Floor, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s12028-019-00677-9DOI Listing
February 2019
1 Read

Incidence of Arterial Hypotension in Patients Receiving Peroral or Continuous Intra-arterial Nimodipine After Aneurysmal or Perimesencephalic Subarachnoid Hemorrhage.

Neurocrit Care 2019 Feb 6. Epub 2019 Feb 6.

Department of Anesthesiology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Background: Oral nimodipine is used for prophylaxis and treatment of delayed cerebral ischemia in patients with aneurysmal or perimesencephalic subarachnoid hemorrhage (SAH). In cases of serious refractory cerebral vasospasm, a continuous intra-arterial (IA) infusion of nimodipine (CIAN) may be required to avoid cerebral ischemia. Nimodipine can cause arterial hypotension requiring either a dosage reduction or its discontinuation. Read More

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http://dx.doi.org/10.1007/s12028-019-00676-wDOI Listing
February 2019
1 Read

Functional Coagulation Differences Between Lobar and Deep Intracerebral Hemorrhage Detected by Rotational Thromboelastometry: A Pilot Study.

Neurocrit Care 2019 Jan 28. Epub 2019 Jan 28.

Vagelos College of Physicians and Surgeons, Columbia University, 177 Fort Washington Ave, New York, NY, 10032, USA.

Background: Lobar intracerebral hemorrhage (ICH) is known to have better clinical outcomes and preliminary evidence of less hematoma expansion compared to deep ICH. No functional coagulation differences between lobar and deep ICH have been identified using traditional plasma-based coagulation tests. We investigated for coagulation differences between lobar and deep ICH using whole-blood coagulation testing (Rotational Thromboelastometry: [ROTEM]). Read More

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http://dx.doi.org/10.1007/s12028-019-00672-0DOI Listing
January 2019
2 Reads

Clinical and Radiological Characteristics of Vitamin K Versus Non-Vitamin K Antagonist Oral Anticoagulation-Related Intracerebral Hemorrhage.

Neurocrit Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

Background/objective: Recent studies indicated that functional outcome after intracranial hemorrhage (ICH) related to direct oral anticoagulation (DOAC-ICH) is similar, if not better, than vitamin K antagonist (VKA)-related ICH (VKA-ICH) due to a smaller initial hematoma volume (HV). However, the association with hematoma expansion (HE) and location is not well understood.

Methods: We retrospectively analyzed 102 consecutive patients with acute non-traumatic ICH on oral anticoagulation therapy to determine HV and HE stratified by hematoma location, and the relation to the 90-day outcome. Read More

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http://link.springer.com/10.1007/s12028-019-00671-1
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http://dx.doi.org/10.1007/s12028-019-00671-1DOI Listing
January 2019
16 Reads
2.440 Impact Factor

Venous and arterial TNF-R1 predicts outcome and complications in acute subarachnoid hemorrhage.

Neurocrit Care 2019 Jan 23. Epub 2019 Jan 23.

Neurovascular Research Laboratory, Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.

Background: There is increasing evidence for the role of inflammation in clinical outcome after subarachnoid hemorrhage (SAH). Specifically, the TNF-alfa(α) pathway seems to be relevant after SAH. Although the TNF-α main receptor, TNF-R1 is associated with aneurysm growth and rupture, its relation to prognosis is unknown. Read More

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http://link.springer.com/10.1007/s12028-019-00669-9
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http://dx.doi.org/10.1007/s12028-019-00669-9DOI Listing
January 2019
2 Reads

Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: Experimental-Clinical Disconnect and the Unmet Need.

Neurocrit Care 2019 Jan 22. Epub 2019 Jan 22.

Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

Background: Delayed cerebral ischemia (DCI) is among the most dreaded complications following aneurysmal subarachnoid hemorrhage (SAH). Despite advances in neurocritical care, DCI remains a significant cause of morbidity and mortality, prolonged intensive care unit and hospital stay, and high healthcare costs. Large artery vasospasm has classically been thought to lead to DCI. Read More

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http://dx.doi.org/10.1007/s12028-018-0650-5DOI Listing
January 2019
25 Reads

The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy-A Matched Pair Analysis.

Neurocrit Care 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background And Purpose: Although the treatment window for mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) has been extended in recent years, it has been proven that recanalizing treatment must be administered as soon as possible. We present a new standard operating procedure (SOP) to reduce in-house delay, standardize periinterventional management and improve patient safety during MT.

Methods: KEep Evaluating Protocol Simplification In Managing Periinterventional Light Sedation for Endovascular Stroke Treatment (KEEP SIMPLEST) was a prospective, single-center observational study aimed to compare aspects of periinterventional management in AIS patients treated according to our new SOP using a combination of esketamine and propofol with patients having been randomized into conscious sedation (CS) in the Sedation versus Intubation for Endovascular Stroke TreAtment (SIESTA) trial. Read More

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http://dx.doi.org/10.1007/s12028-018-00667-3DOI Listing
January 2019
1 Read

Safety and Feasibility of Early Mobilization in Patients with Subarachnoid Hemorrhage and External Ventricular Drain.

Neurocrit Care 2019 Jan 18. Epub 2019 Jan 18.

University of Pennsylvania, Philadelphia, USA.

Background/objective: In November 2014, our Neurointensive Care Unit began a multi-phased progressive early mobilization initiative for patients with subarachnoid hemorrhage and an external ventricular drain (EVD). Our goal was to transition from a culture of complete bed rest (Phase 0) to a physical and occupational therapy (PT/OT)-guided mobilization protocol (Phase I), and ultimately to a nurse-driven mobilization protocol (Phase II). We hypothesized that nurses could mobilize patients as safely as an exclusively PT/OT-guided approach. Read More

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http://dx.doi.org/10.1007/s12028-019-00670-2DOI Listing
January 2019
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Response to "Letter to the Editor" by Couret et al.

Authors:
Charlene Ong

Neurocrit Care 2019 Apr;30(2):494

Division of Neurocritical Care, Department of Neurology, Boston University School of Medicine, Boston, USA.

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http://dx.doi.org/10.1007/s12028-018-0665-yDOI Listing

Stroke Risk Following Infection in Patients with Continuous-Flow Left Ventricular Assist Device.

Neurocrit Care 2019 Jan 14. Epub 2019 Jan 14.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: Infection has been associated with stroke in patients with left ventricular assist devices (LVAD); however, little data exist on the timing, type and mortality impact of infection-related stroke.

Methods: Prospectively collected data of HeartMate II (N = 332) and HeartWare (N = 70) LVAD patients from a single center were reviewed. Only strokes (ischemic or hemorrhagic) that occurred within 6 weeks following a LVAD infection were considered in analyses. Read More

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http://dx.doi.org/10.1007/s12028-018-0662-1DOI Listing
January 2019
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Daptomycin Plasma and CSF Levels in Patients with Healthcare-Associated Meningitis.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, Turin, Italy.

Background: There are currently few data concerning the cerebrospinal fluid (CSF) penetration of daptomycin in patients with healthcare-associated meningitis. This study aims (1) to better characterize the pharmacokinetics of daptomycin in humans during a 7-day intravenous (IV) therapy course, and (2) to study the penetration of daptomycin in the CSF after IV infusion at the dose of 10 mg/kg.

Results: In this prospective observational study, we enrolled nine patients with an implanted external ventricular drainage and a diagnosis of a healthcare-associated meningitis. Read More

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http://dx.doi.org/10.1007/s12028-018-0657-yDOI Listing
January 2019
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Experience in Rehabilitation Medicine Affects Prognosis and End-of-Life Decision-Making of Neurologists: A Case-Based Survey.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Institute for History and Ethics in Medicine, Technical University Munich, Munich, Germany.

Background: Outcome predictions in patients with acute severe neurologic disorders are difficult and influenced by multiple factors. Since the decision for and the extent of life-sustaining therapies are based on the estimated prognosis, it is vital to understand which factors influence such estimates. This study examined whether previous professional experience with rehabilitation medicine influences physician decision-making. Read More

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http://dx.doi.org/10.1007/s12028-018-0661-2DOI Listing
January 2019

Epidemiology-Based Mortality Score is Associated with Long-Term Mortality after Status Epilepticus.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurology, University Hospital of Odense, Sdr. Boulevard 10, 5000, Odense C, Denmark.

Background/objective: Status epilepticus (SE) is a life-threatening condition with a high long-term mortality. The correct prediction of the individual patient's outcome is crucial for stratifying treatment. Status epilepticus severity score (STESS) and the epidemiology-based mortality score (EMSE) are well established for predicting in-hospital mortality; however, scores indicating long-term mortality are lacking. Read More

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http://dx.doi.org/10.1007/s12028-018-0663-0DOI Listing
January 2019

Systematic Review of Intrathecal Nicardipine for the Treatment of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.

Intrathecal nicardipine has been shown to have some efficacy for the treatment of symptomatic cerebral vasospasm in aneurysmal subarachnoid hemorrhage (aSAH). We performed a PRISMA-based systematic review of intrathecal nicardipine for the treatment of cerebral vasospasm in aneurysmal subarachnoid hemorrhage. A total of 825 articles were reviewed. Read More

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http://dx.doi.org/10.1007/s12028-018-0659-9DOI Listing
January 2019
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