5,927 results match your criteria Neurochemistry International[Journal]


Activation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathway.

Neurochem Int 2019 Feb 13. Epub 2019 Feb 13.

Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou, 510006, PR China. Electronic address:

Oxidative stress is an important cause of neurodegenerative diseases. Antioxidant is an potential important method to treat such diseases. The aim of this study is to discover new and effective antioxidants and their mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.026DOI Listing
February 2019

Abuse potential of 2-(4-iodo-2, 5-dimethoxyphenyl)N-(2-methoxybenzyl)ethanamine (25INBOMe); in vivo and ex vivo approaches.

Neurochem Int 2019 Feb 12. Epub 2019 Feb 12.

National Institute of Drug and Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju, Republic of Korea. Electronic address:

25INBOMe ("25-I", "N-Bomb"), one of new psychoactive substances (NPSs), is being abused for recreational purpose. However, the liability for abuse or dependence has not been systematically studied yet. The objective of the present study was to evaluate rewarding and reinforcing effects of 25INBOMe using conditioned place preference (CPP) and self-administration (SA) paradigms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.02.007DOI Listing
February 2019

Forsythiaside prevents β-amyloid-induced hippocampal slice injury by upregulating 2-arachidonoylglycerol via cannabinoid receptor 1-dependent NF-κB pathway.

Neurochem Int 2019 Feb 13;125:57-66. Epub 2019 Feb 13.

Institute of Molecular Science, Shanxi University, Taiyuan, 030006, China. Electronic address:

In the study, the neuroprotectivities of forsythiaside, a main constituent of Forsythia suspensa (Thunb.) Vahl (F. suspensa, Lianqiao in Chinese), were investigated in the hippocampal slices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.02.008DOI Listing
February 2019

Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.

Neurochem Int 2019 Feb 7;125:16-24. Epub 2019 Feb 7.

School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan. Electronic address:

Parkinson's disease (PD) is the second common neurodegenerative disorder. Deficit of the nigro-striatal dopaminergic neurons causes the motor symptoms of PD. While the oxidative stress is thought to be deeply involved in the etiology of PD, molecular targets for the oxidative insults has not been fully elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.02.005DOI Listing
February 2019
1 Read

The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats.

Neurochem Int 2019 Feb 7;125:25-34. Epub 2019 Feb 7.

Departamento de Bioquímica, Centro de Estudos em Estresse Oxidativo, Universidade Federal do Rio Grande do Sul-UFRGS, Brazil. Electronic address:

Vitamin A (retinol) is involved in signaling pathways regulating gene expression and was postulated to be a major antioxidant and anti-inflammatory compound of the diet. Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by loss of nigral dopaminergic neurons, involving oxidative stress and pro-inflammatory activation. The aim of the present study was to evaluate the neuroprotective effects of retinol oral supplementation against 6-hydroxydopamine (6-OHDA, 12 μg per rat) nigrostriatal dopaminergic denervation in Wistar rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.02.002DOI Listing
February 2019
2 Reads
3.092 Impact Factor

The vagus nerve role in antidepressants action: Efferent vagal pathways participate in peripheral anti-inflammatory effect of fluoxetine.

Neurochem Int 2019 Feb 6;125:47-56. Epub 2019 Feb 6.

Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia; Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia. Electronic address:

The mechanisms responsible for the anti-inflammatory effects of antidepressants are only partially understood. Published data indicate that the vagal anti-inflammatory pathway could be involved in mediating this effect. Therefore, we investigated the influence of subdiaphragmatic vagotomy on the anti-inflammatory effect of fluoxetine in rats injected with lipopolysaccharide (LPS) to induce an inflammatory response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.02.003DOI Listing
February 2019

Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia.

Neurochem Int 2019 Feb 5;125:1-6. Epub 2019 Feb 5.

Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Japanese Drug Organization of Appropriate Use and Research, 3-1509 Omoteyama, Tenpaku-ku, Nagoya, Aichi 468-0069, Japan; Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Human Health Sciences, Graduate School of Medicine and Faculty of Medicine, Kyoto University, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Phencyclidine (PCP) is a dissociative anesthetic that induces psychotic symptoms and neurocognitive deficits in rodents similar to those observed in schizophrenia patients. PCP administration in healthy human subjects induces schizophrenia-like symptoms such as positive and negative symptoms, and a range of cognitive deficits. It has been reported that PCP, ketamine, and related drugs such as N-methyl-D-aspartate-type (NMDA) glutamate receptor antagonists, induce behavioral effects by blocking neurotransmission at NMDA receptors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.02.001DOI Listing
February 2019
1 Read

Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression.

Neurochem Int 2019 Feb 1;125:7-15. Epub 2019 Feb 1.

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Denmark.

Altered endocannabinoid (eCB) signalling is suggested as an important contributor to the pathophysiology of depression. To further elucidate this, we conducted a study using a genetic rat model of depression, the Flinders Sensitive Line (FSL), and their controls, the Flinders Resistant Line (FRL) rats. Plasma, right and left prefrontal cortex, and hippocampus were isolated from FSL and FRL rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.023DOI Listing
February 2019

Disentangling the diverse roles of dopamine D2 receptors in striatal function and behavior.

Authors:
Eduardo F Gallo

Neurochem Int 2019 Feb 1;125:35-46. Epub 2019 Feb 1.

Department of Biological Sciences, Fordham University, Bronx, NY, USA. Electronic address:

Dopamine D2 receptors (D2Rs) mediate many of the actions of dopamine in the striatum, ranging from movement to the effortful pursuit of reward. Yet despite significant advances in linking D2Rs to striatal functions with pharmacological and genetic strategies in animals, how dopamine orchestrates its myriad actions on different cell populations -each expressing D2Rs- remains unclear. Furthermore, brain imaging and genetic studies in humans have consistently associated striatal D2R alterations with various neurological and neuropsychiatric disorders, but how and which D2Rs are involved in each case is poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.022DOI Listing
February 2019

Thalamostriatal projections and striosome-matrix compartments.

Neurochem Int 2019 Jan 30;125:67-73. Epub 2019 Jan 30.

Laboratory of Neural Circuitry, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan.

The neostriatum has a mosaic organization consisting of striosome and matrix compartments. It receives glutamatergic excitatory afferents from the cerebral cortex and thalamus. Recent behavioral studies in rats revealed a selectively active medial prefronto-striosomal circuit during cost-benefit decision-making. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.024DOI Listing
January 2019

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.

Neurochem Int 2019 Jan 29. Epub 2019 Jan 29.

Department of Life Science, National Taiwan Normal University, Taipei, 11677, Taiwan. Electronic address:

The pathogenesis of Alzheimer's disease (AD) is involved in the aggregation of misfolded amyloid β (Aβ), which upregulates the activity of acetylcholinesterase (AChE), increases the production of reactive oxygen species (ROS), enhances neuroinflammation, and eventually leads to neuronal death. Therefore, compounds targeting these mechanisms may be candidates for multitarget drugs in AD treatment. We found that two quinoline derivatives, VB-030 and VB-037, markedly reduced Aβ aggregation and ROS levels in the thioflavin T biochemical assay and Tet-On Aβ-green fluorescent protein (GFP) 293 AD cell model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.021DOI Listing
January 2019

Local and systemic metabolic alterations in brain, plasma, and liver of rats in response to aging and ischemic stroke, as detected by nuclear magnetic resonance (NMR) spectroscopy.

Neurochem Int 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurological Surgery, University of Wisconsin, Madison, WI, 53792, USA.

Metabolic dysfunction impacts stroke incidence and outcome. However, the intricate association between altered metabolic program due to aging, and focal ischemia in brain, circulation, and peripheral organs is not completely elucidated. Here we identified locally and systemically altered metabolites in brain, liver, and plasma as a result of normal aging, ischemic-stroke, and extended time of reperfusion injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.025DOI Listing
January 2019

Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice.

Neurochem Int 2019 Mar 25;124:256-263. Epub 2019 Jan 25.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address:

Sleep and wakefulness are controlled by a wide range of neuronal populations in the mammalian brain. Activation of adenosine A receptor (AR)-expressing neurons in the nucleus accumbens (NAc) core promotes slow-wave sleep (SWS). The neuronal mechanism by which activation of NAc AR neurons induces SWS, however, is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.020DOI Listing

Neurochemical impact of the 5-HT receptor agonist WAY-163909 on monoamine tissue content in the rat brain.

Neurochem Int 2019 Mar 24;124:245-255. Epub 2019 Jan 24.

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5287, 33076, Bordeaux Cedex, France. Electronic address:

Serotonin2C receptor (5-HT) agonists are promising drugs for the treatment of neuropsychiatric diseases. However, their effect is not completely understood in part because they possibly affect several neurobiological networks simultaneously. We studied the effect of the 5-HT receptor agonist WAY-163909 (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.019DOI Listing
March 2019
1 Read

Glutathione peroxidase-1 overexpressing transgenic mice are protected from cocaine-induced drug dependence.

Neurochem Int 2019 Mar 24;124:264-273. Epub 2019 Jan 24.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea. Electronic address:

Converging evidence has demonstrated that oxidative burdens are associated with drug dependence induced by psychostimulants. Here, we investigated whether oxidative stress directly mediates conditioned place preference and behavioral sensitization (drug dependence) induced by cocaine and whether glutathione peroxidase-1 (GPx-1), a major GPx, modulates cocaine-induced psychotoxic changes in mice. Cocaine-induced drug dependence was followed by increases in c-Fos-immunoreactivity (c-Fos-IR) in the nucleus accumbens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.018DOI Listing
March 2019
4 Reads
3.092 Impact Factor

Therapeutic potential of PACAP in alcohol toxicity.

Neurochem Int 2019 Mar 22;124:238-244. Epub 2019 Jan 22.

Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA.

Alcohol addiction is a worldwide concern as its detrimental effects go far beyond the addicted individual and can affect the entire family as well as the community. Considerable effort is being expended in understanding the neurobiological basis of such addiction in hope of developing effective prevention and/or intervention strategies. In addition, organ damage and neurotoxicological effects of alcohol are intensely investigated. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183055
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.017DOI Listing
March 2019
2 Reads

Cdh1 overexpression improves emotion and cognitive-related behaviors via regulating hippocampal neuroplasticity in global cerebral ischemia rats.

Neurochem Int 2019 Mar 21;124:225-237. Epub 2019 Jan 21.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Post-stroke survivors exhibited cognitive deficits and performed emotional impairment. However, the effect of global cerebral ischemia on standard behavioral measures of emotionality and underlying mechanism remain largely unknown. Our previous work identified that down-regulation of Cdh1 contributed to ischemic neuronal death in rat, thus we hypothesized that Cdh1 exerts a role in emotionality after cerebral ischemia, and we investigated the effect of Cdh1 overexpression on neurogenic behaviors and possible mechanisms in transient global cerebral ischemia reperfusion (tGCI/R) rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.015DOI Listing
March 2019
1 Read

Protocatechuic acid improves functional recovery after spinal cord injury by attenuating blood-spinal cord barrier disruption and hemorrhage in rats.

Neurochem Int 2019 Mar 18;124:181-192. Epub 2019 Jan 18.

Age-Related and Brain Diseases Research Center, Kyung Hee University, Seoul, 02447, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address:

After spinal cord injury (SCI), blood-spinal cord barrier (BSCB) disruption and hemorrhage lead to blood cell infiltration and progressive secondary injuries including inflammation. Inflammatory response is one of the major events resulting in apoptosis, scar formation and neuronal dysfunction after SCI. Here, we investigated whether protocatechuic acid (PCA), a natural phenolic compound, would attenuate BSCB disruption and hemorrhage, leading to functional improvement after SCI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.013DOI Listing
March 2019
3 Reads

Chronic methylphenidate preferentially alters catecholamine protein targets in the parietal cortex and ventral striatum.

Neurochem Int 2019 Mar 17;124:193-199. Epub 2019 Jan 17.

Pharmacology and Neuroscience Research Group, Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester, LE1 9BH, UK. Electronic address:

The psychostimulant methylphenidate (MPH) is the primary drug treatment for attention deficit hyperactivity disorder (ADHD) in children. MPH is well known to acutely block the dopamine (DAT) and noradrenaline (NET) transporters. Its effect on additional catecholamine targets is however less known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.016DOI Listing
March 2019
1 Read

It takes two to tango: Dorsal direct and indirect pathways orchestration of motor learning and behavioral flexibility.

Neurochem Int 2019 Mar 16;124:200-214. Epub 2019 Jan 16.

Laboratory of Neurophysiology, Université libre de Bruxelles, ULB Neuroscience Institute ULB-UNI, Brussels, Belgium; WELBIO, Wavre, Belgium. Electronic address:

The striatum as the main entry nucleus of the basal ganglia is long known to be critical for motor control. It integrates information from multiple cortical areas, thalamic and midbrain nuclei to refine and control motion. By tackling this incredible variety of input signals, increasing evidences showed a pivotal role, particularly of the dorsal striatum, in executive functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.009DOI Listing

Age and sex differences in the pathophysiology of acute CNS injury.

Neurochem Int 2019 Jan 14. Epub 2019 Jan 14.

Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA; Cellular and Molecular Pathology Program, University of Wisconsin, Madison, WI, USA; William S. Middleton Veterans Administration Hospital, Madison, WI, USA. Electronic address:

Despite the immeasurable burden on patients and families, no effective therapies to protect the CNS after an acute injury are available yet. Furthermore, the underlying mechanisms that promote neuronal death and functional deficits after injury remain to be poorly understood. The prevalence, age of onset, pathophysiology, and symptomatology of many CNS insults differ significantly between males and females. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.012DOI Listing
January 2019
1 Read
3.092 Impact Factor

Significance of protein kinase C in the neuropsychotoxicity induced by methamphetamine-like psychostimulants.

Neurochem Int 2019 Mar 14;124:162-170. Epub 2019 Jan 14.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Republic of Korea. Electronic address:

The abuse of methamphetamine (MA), an amphetamine (AMPH)-type stimulant, has been demonstrated to be associated with various neuropsychotoxicity, including memory impairment, psychiatric morbidity, and dopaminergic toxicity. Compelling evidence from preclinical studies has indicated that protein kinase C (PKC), a large family of serine/threonine protein kinases, plays an important role in MA-induced neuropsychotoxicity. PKC-mediated N-terminal phosphorylation of dopamine transporter has been identified as one of the prerequisites for MA-induced synaptic dopamine release. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183054
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.014DOI Listing
March 2019
4 Reads

Inhibition of miR-497 improves functional outcome after ischemic stroke by enhancing neuronal autophagy in young and aged rats.

Neurochem Int 2019 Jan 15. Epub 2019 Jan 15.

Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA. Electronic address:

Over the years miR-497 has been found to play a vital role in the pathogenesis of neurological diseases, including ischemic stroke. However, its underlying mechanism remains largely unexplored. Here, we used miR-497 agomir (miR-497 agonist), miR-497 antagomir (miR-497 inhibitor) and 3-MA (autophagy inhibitor) to treat ischemic rats (n = 10-12 per group) induced by permanent distal middle cerebral artery occlusion (dMCAO), followed the functional outcome assessment 24 h after dMCAO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.005DOI Listing
January 2019
1 Read

Developmental differences in microglia morphology and gene expression during normal brain development and in response to hypoxia-ischemia.

Neurochem Int 2019 Jan 9. Epub 2019 Jan 9.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Background: Neuroinflammation plays an important role in ischemic brain injury and recovery, however the interplay between brain development and the neuroinflammatory response is poorly understood. We previously described age-dependent differences in the microglial response and the effect of microglial inhibition. Here we investigate whether age-dependent microglial responses may be related to pre-injury developmental differences in microglial phenotype. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.016DOI Listing
January 2019
2 Reads
3.092 Impact Factor

In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ) toxicity and aggregation.

Neurochem Int 2019 Mar 9;124:215-224. Epub 2019 Jan 9.

Centre for Marine Bioproducts Development (CMBD), College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia; Medical Biotechnology, College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia. Electronic address:

Amyloid beta (Aβ) can aggregate and form plaques, which are considered as one of the major hallmarks of Alzheimer's disease. This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against Aβ-mediated toxicity in pheochromocytoma (PC-12) neuronal cells using the MTT cell viability assay, anti-apoptotic, antioxidant and neurite outgrowth activities; as well as inhibition against Aβ fibrillization in the Thioflavin T (ThT) assay of fibril kinetics and via transmission electron microscopic (TEM) evaluation of fibril morphology. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183024
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.010DOI Listing
March 2019
9 Reads

The effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice.

Neurochem Int 2019 Mar 11;124:171-180. Epub 2019 Jan 11.

Division of System Neurophysiology, National Institute for Physiological Sciences, 38, Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585, Japan; Department of Physiological Sciences, SOKENDAI (The Graduate University for Advanced Studies), 38, Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585, Japan. Electronic address:

Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain and shows motor dysfunctions. Zonisamide (ZNS, 1,2-benzisoxazole-3-methanesulfonamide), which was originally developed as an antiepileptic drug, was also found to have beneficial effects on motor symptoms in PD. In the current study, we have investigated the behavioral and physiological effects of ZNS on L-DOPA-induced dyskinesia (LID) in PD model mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.011DOI Listing

Sex-dependent effect on mitochondrial and oxidative stress parameters in the hypothalamus induced by prepubertal stress and access to high fat diet.

Neurochem Int 2019 Mar 11;124:114-122. Epub 2019 Jan 11.

Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objective: Some factors related to lifestyle, including stress and high-fat diet (HFD) consumption, are associated with higher prevalence of obesity. These factors can lead to an imbalance between ROS production and antioxidant defenses and to mitochondrial dysfunctions, which, in turn, could cause metabolic impairments, favoring the development of obesity. However, little is known about the interplay between these factors, particularly at early ages, and whether long-term sex-specific changes may occur. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.008DOI Listing

Long-term application of cannabinoids leads to dissociation between changes in cAMP and modulation of GABA receptors of mouse trigeminal sensory neurons.

Neurochem Int 2019 Jan 8. Epub 2019 Jan 8.

Neuroscience Department, International School for Advanced Studies (SISSA), Trieste, Italy. Electronic address:

Antinociception caused by cannabinoids may have a partial peripheral origin in addition to its central site of action. In fact, we have observed that anandamide selectively and reversibly inhibits GABA receptors of putative nociceptive neurons of mouse trigeminal sensory ganglia via CB1 receptor activation to inhibit adenylyl cyclase and decrease cAMP with downstream posttranslational alterations. Since cannabinoids are often used chronically, we studied changes in cAMP levels and GABA-mediated currents of trigeminal neurons following 24 h application of anandamide (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.007DOI Listing
January 2019

The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1.

Neurochem Int 2019 Mar 8;124:123-129. Epub 2019 Jan 8.

The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Institute of Urology of Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036, Guangdong, China. Electronic address:

The histone demethylase KDM6B, also known as jumonji domain-containing protein 3 (JMJD3), is an epigenetic regulator which plays important roles in immune activation, tissue regeneration, cellular senescence and cancer metastasis. But, the role of KDM6B in glioma metastasis is poorly understood. In this study, we achieved transcriptional regulation of KDM6B in glioma cells using CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183032
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.006DOI Listing
March 2019
3 Reads

L-NBP, a multiple growth factor activator, attenuates ischemic neuronal impairments possibly through promoting neuritogenesis.

Neurochem Int 2019 Mar 7;124:94-105. Epub 2019 Jan 7.

Beijing Institute of Brain Disorders & Research Center for Brain Disorders, Capital Medical University, Beijing, 100069, PR China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China. Electronic address:

In China, L-3-n-butylphthalide (L-NBP) showed promising pharmacological actions in stroke treatment. Analyzing the characteristics of L-NBP might provide valuable hints for new drug design. The current study is aimed to determine the effects of L-NBP on neuritogenesis and further to elucidate the neuronal protection against stroke impairment in vitro. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183050
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.002DOI Listing
March 2019
7 Reads

GAD1 gene polymorphisms are associated with bipolar I disorder and with blood homovanillic acid levels but not with plasma GABA levels.

Neurochem Int 2019 Mar 6;124:152-161. Epub 2019 Jan 6.

Departamento de Investigación Neuroquímica, Hospital de Zamudio, Red de Salud Mental de Bizkaia, Zamudio, Spain; BioCruces Health Research Institute, Barakaldo, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.004DOI Listing
March 2019
3 Reads

Methamphetamine use causes cognitive impairment and altered decision-making.

Neurochem Int 2019 Mar 3;124:106-113. Epub 2019 Jan 3.

Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, 466-8560, Japan. Electronic address:

Methamphetamine is a widely abused psychostimulant. It reverses transport through the dopamine transporter, thereby increasing the extracellular level of dopamine in the brain, which is associated with the rewarding effect. Repeated intake of methamphetamine leads to drug addiction, a chronically relapsing disorder characterized by compulsive drug taking, inability to limit intake, and intense drug cravings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.019DOI Listing
March 2019
10 Reads

Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways.

Neurochem Int 2019 Mar 3;124:141-151. Epub 2019 Jan 3.

Key Laboratory of Minstry of Education for TCM Viscera State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, China. Electronic address:

Ischemic stroke is the third most common cause of death and the leading cause of disability worldwide in adults. The antiepileptic drug valproic acid (VPA) was reported to protect cerebral ischemia/reperfusion injury. However, the action mechanism of VPA in cerebral ischemia/reperfusion injury has not been fully understood. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183015
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.01.003DOI Listing
March 2019
5 Reads

Mechanisms of action of paraoxon, an organophosphorus pesticide, on in vivo dopamine release in conscious and freely moving rats.

Neurochem Int 2019 Mar 3;124:130-140. Epub 2019 Jan 3.

Department of Functional Biology and Health Sciences, Faculty of Biology, University of Vigo, Campus Lagoas Marcosende, 36310, Vigo, Spain.

Paraoxon is the active metabolite of parathion, an organophosphorus pesticide which can cause neurotoxic effects in animals and humans. In the present work, we investigated the effects of 5 mM paraoxon on striatal dopamine, DOPAC and HVA levels in conscious and freely moving rats, after treatment with TTX, reserpine, nomifensine, KCl, Ca-free/EDTA medium, AP-5 or L-NAME. The intrastriatal administration of paraoxon for 60 min, through the microdialysis probe, significantly produced an increase of the dopamine to 1066 ± 120%, relative to basal levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2019.01.001DOI Listing

Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research.

Neurochem Int 2018 Dec 29. Epub 2018 Dec 29.

Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA. Electronic address:

Brain ischemia induced by cardiac arrest or ischemic stroke is a severe form of metabolic stress that substantially disrupts cellular homeostasis, especially protein homeostasis (proteostasis). As proteostasis is fundamental for cellular and organismal health, cells have developed a complex network to restore proteostasis impaired by stress. Many components of this network - including ubiquitination, small ubiquitin-like modifier (SUMO) conjugation, autophagy, and the unfolded protein response (UPR) - are activated in the post-ischemic brain, and play a crucial role in cell survival and recovery of neurologic function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.018DOI Listing
December 2018

P53 knockout mice are protected from cocaine-induced kindling behaviors via inhibiting mitochondrial oxidative burdens, mitochondrial dysfunction, and proapoptotic changes.

Neurochem Int 2019 Mar 29;124:68-81. Epub 2018 Dec 29.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea. Electronic address:

Previously we demonstrated that p53 mediates dopaminergic neurotoxicity via inducing mitochondrial burdens and proapoptotsis. However, little is known about the role of p53 in the excitotoxicity induced by psychostimulant, such as cocaine. Cocaine-induced kindling (convulsive) behaviors significantly increased p53 expression in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.017DOI Listing
March 2019
1 Read

Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells.

Neurochem Int 2019 Mar 26;124:82-93. Epub 2018 Dec 26.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand. Electronic address:

Melatonin, a highly lipophilic molecule secreted by the pineal gland in the brain, plays a role in various biological functions. Previous studies reported that melatonin exerts its effect on mesenchymal stem cell (MSC) survival and differentiation into osteogenic- and adipogenic-lineage. However, the effect of melatonin in neurogenic differentiation in amniotic fluid (AF)-MSCs remains to be explored, thus we investigated the potential role of melatonin on dopaminergic neuron differentiation in AF-MSCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.012DOI Listing

Sildenafil treatment of vascular dementia in aged rats.

Neurochem Int 2018 Dec 25. Epub 2018 Dec 25.

Department of Neurology, Henry Ford Hospital, Detroit, MI, 48202, USA. Electronic address:

Background: and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline, white matter damage, autophagy and inflammatory response associated with VaD.

Methods: Male, aged (16-18 months) Wistar rats were subjected to MMI (800 ± 100, 70-100 μm cholesterol crystals injected into the internal carotid artery) and treated with or without Sildenafil (2 mg/kg, i.p) starting at 24 h after MMI daily for 28 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.015DOI Listing
December 2018
3 Reads
3.092 Impact Factor

Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy.

Neurochem Int 2018 Dec 23. Epub 2018 Dec 23.

Department of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA. Electronic address:

Interferon regulatory factor 4 (IRF4), a transcription factor recognized as a key regulator of lymphoid and myeloid cell differentiation, has recently been recognized as a critical mediator of macrophage activation. Previously we have reported that IRF4 signaling is closely correlated with anti-inflammatory polarization of microglia in adult mice after stroke. However, IRF4's role in the inflammatory response in the immature brain is unknown. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183046
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2018.12.014DOI Listing
December 2018
6 Reads
3.092 Impact Factor

Chitinase-3-like protein 1 may be a potential biomarker in patients with drug-resistant epilepsy.

Neurochem Int 2019 Mar 22;124:62-67. Epub 2018 Dec 22.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address:

The mechanisms of the pathogenesis of epilepsy remain unclear. Recent research shows that the inflammatory process occurring in the brain may be a common and critical mechanism of seizures. Chitinase-3-like protein 1 (CHI3L1 or YKL-40) is a newly discovered inflammatory factor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.013DOI Listing
March 2019
3.092 Impact Factor

Anti-neurofascin autoantibody and demyelination.

Neurochem Int 2018 Dec 22. Epub 2018 Dec 22.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Demyelination diseases involving the central and peripheral nervous systems are etiologically heterogeneous with both cell-mediated and humoral immunities playing pathogenic roles. Recently, autoantibodies against nodal and paranodal proteins, such as neurofascin186 (NF186), neurofascin155 (NF155), contactin-1 (CNTN1), contactin-associated protein 1 (CASPR1) and gliomedin, have been discovered in not only chronic demyelinating conditions, such as multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy, but also in acute demyelinating conditions, such as Guillain-Barré syndrome. Only a minority of these patients harbor anti-nodal/paranodal protein antibodies; however, these autoantibodies, especially IgG4 subclass autoantibodies to paranodal proteins, are associated with unique features and these conditions are collectively termed nodopathy or paranodopathy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183043
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2018.12.011DOI Listing
December 2018
9 Reads

Comparison of spontaneous and mechanically-stimulated adenosine release in mice.

Neurochem Int 2019 Mar 20;124:46-50. Epub 2018 Dec 20.

Department of Chemistry, University of Virginia, Charlottesville, VA, 22904, USA. Electronic address:

Rapid adenosine signaling, on the time frame of seconds, has been discovered in the brain that can modulate neurotransmission or blood flow. Rapid adenosine release can occur spontaneously or be evoked after a mechanical stimulation, but these two modes of adenosine have not been compared. Here, we compared spontaneous and mechanically-stimulated adenosine release in the prefrontal cortex, striatum, and hippocampus of anesthetized mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369016PMC
March 2019
1 Read

Quantitative iTRAQ-based proteomic analysis of piperine protected cerebral ischemia/reperfusion injury in rat brain.

Neurochem Int 2019 Mar 21;124:51-61. Epub 2018 Dec 21.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Department of Neurosurgery, Tongji Hospital of Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address:

Piperine is the key bioactive factor in black pepper, and has been reported to alleviate cerebral ischemic injury. However, the mechanisms underlying its neuroprotective effects following cerebral ischemia remain unclear. In this study, rats were administered vehicle (dimethyl sulfoxide) or piperine, 20 mg/kg, daily for 14 days before focal cerebral artery occlusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.010DOI Listing

TDP-43 levels are higher in platelets from patients with sporadic amyotrophic lateral sclerosis than in healthy controls.

Neurochem Int 2019 Mar 20;124:41-45. Epub 2018 Dec 20.

Department of Neurology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of ubiquitinated inclusions in motor neurons of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is ubiquitously expressed and the majority of TDP-43 is normally localized to the nucleus. In motor neurons of patients with ALS, TDP-43 is not localized in the nucleus, relocates to the cytoplasm, and accumulates as cytoplasmic inclusions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.009DOI Listing

NADPH oxidase inhibitor apocynin decreases mitochondrial dysfunction and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging model in rats.

Neurochem Int 2019 Mar 20;124:31-40. Epub 2018 Dec 20.

Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China. Electronic address:

Presbycusis has become a common sensory deficit in humans. Oxidative damage to mitochondrial DNA and mitochondrial dysfunction is strongly associated with the aging of the auditory system. A previous study established a mimetic rat model of aging using D-galactose (D-gal) and first reported that NADPH oxidase-dependent mitochondrial oxidative damage and apoptosis in the ventral cochlear nucleus (VCN) might contribute to D-gal-induced central presbycusis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.008DOI Listing

The brain in flux: Genetic, physiologic, and therapeutic perspectives on transporters in the CNS.

Neurochem Int 2019 Feb 17;123:1-6. Epub 2018 Dec 17.

Departments of Pediatrics and Systems Pharmacology and Translational Therapeutics, Children's Hospital of Philadelphia/University of Pennsylvania, Philadelphia, PA, 19104, United States. Electronic address:

The brain has specific properties that make it uniquely dependent upon transporters. This is the 3rd edition of a biennial special issue that originates from a scientific meeting devoted to studies of transporters and their relationship to brain function and to neurodevelopmental, neurologic, and psychiatric disorders. The field continues to rapidly evolve with advances in studies of structure that inform mechanism, with genetic analyses in humans revealing surprising aspects of biology, and with integrated cellular to whole animal analyses of the role of transporters in their control of physiology and pathophysiology. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183069
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2018.12.006DOI Listing
February 2019
9 Reads

A novel synthetic cathinone, α-pyrrolidinopentiothiophenone (PVT), produces locomotor sensitization in rat: Implications for GSK3β connections in the nucleus accumbens core.

Neurochem Int 2019 Mar 18;124:25-30. Epub 2018 Dec 18.

Department of Physiology, Brain Korea 21 Plus Project for Medical Science, Brain Research Institute, Yonsei University College of Medicine, Seoul, 03722, South Korea. Electronic address:

A novel psychoactive substance, α-pyrrolidinopentiothiophenone (α-PVT), is a structural analog to amphetamine. Recently, it has been shown that α-PVT has an abuse potential similar to psychomotor stimulants like cocaine or amphetamine. However, it has not been performed yet to determine whether α-PVT develops behavioral sensitization, a well-known phenomenon for psychomotor stimulants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.005DOI Listing
March 2019
1 Read

Expression of immediate early genes in brain reward circuitries: Differential regulation by psychostimulant and opioid drugs.

Neurochem Int 2019 Mar 14;124:10-18. Epub 2018 Dec 14.

NIDA Intramural Program, Molecular Neuropsychiatry Research Branch, 251 Bayview Boulevard, Baltimore, MD, 21224, USA. Electronic address:

Although some of the clinical manifestations of substance use disorders might be superficially similar, it is highly likely that different classes of abused drugs including opioids (heroin, morphine, and oxycodone, other opioids) and psychostimulants (cocaine and amphetamines) cause different neuroadaptations in various brain regions dependent in the distribution and concentration of their biochemical sites of actions. In fact, different molecular networks are indeed impacted by acute and chronic administration of addictive substances. Some of the genes whose expression is influenced by the administration of these substances are immediate-early genes (IEGs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.004DOI Listing
March 2019
7 Reads

Nicotine protects against manganese and iron-induced toxicity in SH-SY5Y cells: Implication for Parkinson's disease.

Neurochem Int 2019 Mar 14;124:19-24. Epub 2018 Dec 14.

Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA. Electronic address:

Manganese (Mn) and iron (Fe) are trace elements that are essential for proper growth and physiological functions as both play critical role in a variety of enzymatic reactions. At high concentrations, however, they can be toxic and cause neurodegenerative disorders, particularly Parkinson-like syndromes. Nicotine, on the other hand, has been shown to have neuroprotective effects against various endogenous or exogenous toxins that selectively damage the dopaminergic cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369010PMC