8,359 results match your criteria Neurochemical research[Journal]


Astroglial Mechanisms of Ketamine Action Include Reduced Mobility of Kir4.1-Carrying Vesicles.

Neurochem Res 2019 Feb 22. Epub 2019 Feb 22.

Celica BIOMEDICAL, Tehnološki park 24, 1000, Ljubljana, Slovenia.

The finding that ketamine, an anaesthetic, can elicit a rapid antidepressant effect at low doses that lasts for weeks in patients with depression is arguably a major achievement in psychiatry in the last decades. However, the mechanisms of action are unclear. The glutamatergic hypothesis of ketamine action posits that ketamine is a N-methyl-D-aspartate receptor (NMDAR) antagonist modulating downstream cytoplasmic events in neurons. Read More

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http://dx.doi.org/10.1007/s11064-019-02744-1DOI Listing
February 2019

Consequences of a Metabolic Glucose-Depletion on the Survival and the Metabolism of Cultured Rat Astrocytes.

Neurochem Res 2019 Feb 20. Epub 2019 Feb 20.

Centre for Biomolecular Interactions Bremen, Faculty 2 (Biology/Chemistry), University of Bremen, P.O. Box 330440, 28334, Bremen, Germany.

Brain astrocytes are considered to be highly glycolytic, but these cells also produce ATP via mitochondrial oxidative phosphorylation. To investigate how a metabolic depletion of glucose will affect the metabolism of astrocytes, we applied glucose at an initial concentration of 2 mM to cultured primary astrocytes and monitored the cell viability and various metabolic parameters during an incubation for up to 2 weeks. Already within 2 days of incubation the cells had completely consumed the applied glucose and lactate had accumulated in the medium to a concentration of around 3 mM. Read More

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http://dx.doi.org/10.1007/s11064-019-02752-1DOI Listing
February 2019

Astroglia in Sepsis Associated Encephalopathy.

Neurochem Res 2019 Feb 18. Epub 2019 Feb 18.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK.

Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components and endotoxins, which all damage the brain barriers, instigate neuroinflammation and cause homeostatic failure. Astrocytes, being the principal homeostatic cells of the central nervous system contribute to the brain defence against infection. Read More

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http://dx.doi.org/10.1007/s11064-019-02743-2DOI Listing
February 2019

Resveratrol Abrogates Hypoxia-Induced Up-Regulation of Exosomal Amyloid-β Partially by Inhibiting CD147.

Neurochem Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.

Hypoxia promotes both total extracellular and exosomal amyloid-β (Aβ) production and aggravates Alzheimer's disease (AD). Resveratrol (RSV) has been proved to be neuroprotective in AD models, and down-regulated the expression of CD147, an additional subunit of γ-secretase. In this study, we aimed to explore the role and mechanisms of RSV in hypoxia-induced upregulation of Aβ, especially exosomal Aβ. Read More

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http://dx.doi.org/10.1007/s11064-019-02742-3DOI Listing
February 2019

NMDA Receptors in Astrocytes.

Neurochem Res 2019 Feb 14. Epub 2019 Feb 14.

LBCC Healthcare s.r.o, Prague, Czech Republic.

Astrocytes support glutamatergic neurotransmission in the central nervous system through multiple mechanisms which include: (i) glutamate clearance and control over glutamate spillover due to operation of glutamate transporters; (ii) supply of obligatory glutamate precursor glutamine via operation of glutamate-glutamine shuttle; (iii) supply of L-serine, the indispensable precursor of positive NMDA receptors neuromodulator D-serine and (iv) through overall homoeostatic control of the synaptic cleft. Astroglial cells express an extended complement of ionotropic and metabotropic glutamate receptors, which mediate glutamatergic input to astrocytes. In particular a sub-population of astrocytes in the cortex and in the spinal cord express specific type of NMDA receptors assembled from two GluN1, one GluN2C or D and one GluN3 subunits. Read More

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http://dx.doi.org/10.1007/s11064-019-02750-3DOI Listing
February 2019
1 Read

The VGVAPG Peptide Regulates the Production of Nitric Oxide Synthases and Reactive Oxygen Species in Mouse Astrocyte Cells In Vitro.

Neurochem Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Biochemistry and Laboratory Diagnostics, Institute of Medicine, University of Opole, Oleska 48, 45-052, Opole, Poland.

The products of elastin degradation, namely elastin-derived peptides (EDPs), are detectable in the cerebrospinal fluid of healthy individuals and in patients after ischemic stroke, and their number increases with age. Depending on their concentrations, both nitric oxide (NO) and reactive oxygen species (ROS) take part either in myocardial ischemia reperfusion injury or in neurovascular protection after ischemic stroke. The aim of our study was to determine the impact of VGVAPG peptide on ROS and NO production and expression of endothelial nitric oxide synthase (eNos), inducible nitric oxide synthase (iNos) and neuronal nitric oxide synthase (nNos) in mouse cortical astrocytes in vitro. Read More

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http://dx.doi.org/10.1007/s11064-019-02746-zDOI Listing
February 2019

Effects of α-Synuclein Monomers Administration in the Gigantocellular Reticular Nucleus on Neurotransmission in Mouse Model.

Neurochem Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Banacha 1B, 02-097, Warsaw, Poland.

The aim of the study was to examine the Braak's hypothesis to explain the spreading and distribution of the neuropathological changes observed in the course of Parkinson's disease among ascending neuroanatomical regions. We investigated the neurotransmitter levels (monoamines and amino acid concentration) as well as tyrosine hydroxylase (TH) and transglutaminase-2 (TG2) mRNA expression in the mouse striata (ST) after intracerebral α-synuclein (ASN) administration into gigantocellular reticular nucleus (Gi). Male C57BL/10 Tar mice were used in this study. Read More

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http://dx.doi.org/10.1007/s11064-019-02732-5DOI Listing
February 2019

Modulating P1 Adenosine Receptors in Disease Progression of SOD1 Mutant Mice.

Neurochem Res 2019 Feb 12. Epub 2019 Feb 12.

National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.

Amyotrophic lateral sclerosis (ALS) is a fatal progressing neurodegenerative disease; to date, despite the intense research effort, only two therapeutic options, with very limited effects, are available. The purinergic system has been indicated as a possible new therapeutic target for ALS, but the results are often contradictory and generally confused. The present study was designed to determine whether P1 adenosine receptor ligands affected disease progression in a transgenic model of ALS. Read More

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http://dx.doi.org/10.1007/s11064-019-02745-0DOI Listing
February 2019
2 Reads

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation.

Neurochem Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

Clinically, superimposed systemic inflammation generally has significant deleterious effects on the Alzheimer's disease (AD) progression. However, the related molecular mechanisms remain poorly understood. Microglial toll-like receptor 4 (TLR4) and triggering receptor expressed on myeloid cells 2 (TREM2) are two key regulators of inflammation that may play an essential role in this complex pathophysiological process. Read More

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http://dx.doi.org/10.1007/s11064-019-02748-xDOI Listing
February 2019

Expression Changes of NMDA and AMPA Receptor Subunits in the Hippocampus in rats with Diabetes Induced by Streptozotocin Coupled with Memory Impairment.

Neurochem Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, 1168 West Chunrong Road, Kunming, 650500, People's Republic of China.

Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR); however, the pathogenesis involved in this has not been fully understood, especially at early phase of DM. Here, we sought to determine the cognitive changes and aim to correlate this with the expression changes of NMDAR and AMPAR of glutamate signaling pathways in the rat hippocampus from early phase of DM and in the course of the disease progression. Read More

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http://dx.doi.org/10.1007/s11064-019-02733-4DOI Listing
February 2019

Neuroprotective Effects of Thymoquinone in Acrylamide-Induced Peripheral Nervous System Toxicity Through MAPKinase and Apoptosis Pathways in Rat.

Neurochem Res 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Acrylamide (ACR) is extensively used in industrial areas and has been demonstrated to induce neurotoxicity via oxidative stress and apoptosis. In this study, we assessed the probable protective effects of thymoquinone (TQ), an active constituent of Nigella sativa, against ACR-induced neurotoxicity. ACR (50 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s11064-019-02741-4DOI Listing
February 2019
2 Reads

Increase in Glutamatergic Terminals in the Striatum Following Dopamine Depletion in a Rat Model of Parkinson's Disease.

Neurochem Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Dopaminergic neuron degeneration is known to give rise to dendrite injury and spine loss of striatal neurons, however, changes of intrastriatal glutamatergic terminals and their synapses after 6-hydroxydopamine (6OHDA)-induced dopamine (DA)-depletion remains controversial. To confirm the effect of striatal DA-depletion on the morphology and protein levels of corticostriatal and thalamostriatal glutamatergic terminals and synapses, immunohistochemistry, immuno-electron microscope (EM), western blotting techniques were performed on Parkinson's disease rat models in this study. The experimental results of this study showed that: (1) 6OHDA-induced DA-depletion resulted in a remarkable increase of Vesicular glutamate transporter 1 (VGlut1) + and Vesicular glutamate transporter 2 (VGlut2)+ terminal densities at both the light microscope (LM) and EM levels, and VGlut1+ and VGlut2+ terminal sizes were shown to be enlarged by immuno-EM; (2) Striatal DA-depletion resulted in a decrease in both the total and axospinous terminal fractions of VGlut1+ terminals, but the axodendritic terminal fraction was not significantly different from the control group. Read More

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http://dx.doi.org/10.1007/s11064-019-02739-yDOI Listing
February 2019

Cytosolic HMGB1 Mediates Autophagy Activation in an Emulsified Isoflurane Anesthesia Cell Model.

Neurochem Res 2019 Feb 2. Epub 2019 Feb 2.

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, No.126, Xiantai Rd, Changchun, 130000, China.

Inhalation anesthetic isoflurane may cause an increased risk of cognitive impairment. Previous studies have indicated that this cognitive decline is associated with neuroinflammation mediated by high mobility group box 1 (HMGB1). HMGB1 is released from cells and acts as a damage-associated molecule in neurodegenerative diseases. Read More

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http://link.springer.com/10.1007/s11064-019-02740-5
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http://dx.doi.org/10.1007/s11064-019-02740-5DOI Listing
February 2019
2 Reads

Cortical Spreading Depolarization (CSD) Recorded from Intact Skin, from Surface of Dura Mater or Cortex: Comparison with Intracortical Recordings in the Neocortex of Adult Rats.

Neurochem Res 2019 Feb 1. Epub 2019 Feb 1.

Institute of Physiology I/Neurophysiology, University Hospital Jena - Friedrich Schiller University Jena, Teichgraben 8, 07740, Jena, Germany.

In cerebral cortex of anesthetized rats single waves of spreading depolarization (CSD) were elicited by needle prick. CSD-related changes of DC (direct current) potentials were either recorded from the intact skin or together with concomitant changes of potassium concentration with K-selective microelectrodes simultaneously at the surface of the dura mater or of the cortex ([K]) and in the extracellular space at a cortical depth of 1200 µm. At the intact skin CSD-related DC-shifts had amplitudes of less than 1 mV and had only in a minority of cases the typical CSD-like shape. Read More

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http://dx.doi.org/10.1007/s11064-019-02737-0DOI Listing
February 2019

SSeCKS promoted lipopolysaccharide-sensitized astrocytes migration via increasing β-1,4-galactosyltransferase-I activity.

Neurochem Res 2019 Jan 31. Epub 2019 Jan 31.

Ningbo College of Health Sciences, Ningbo, 315211, Zhejiang, People's Republic of China.

Astrocytes migration is essential in the formation of the glial scar during the injury response process of the central nervous system (CNS) especially during inflammation. Integrin β1 is part of the extracellular matrix receptors in the CNS and it has been reported that integrin β-deficient astrocytes randomly migrate into wounds. Previous studies have found that β-1,4 Galactosyltransferase-I (β-1,4-GalT-I) enhanced the β-1,4-galactosylation of integrin β1. Read More

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http://dx.doi.org/10.1007/s11064-019-02716-5DOI Listing
January 2019

Dexmedetomidine Promotes SH-SY5Y Cell Resistance Against Impairment of Iron Overload by Inhibiting NF-κB Pathways.

Neurochem Res 2019 Jan 29. Epub 2019 Jan 29.

School of Medicine, Shandong University, Jinan, 250012, Shandong, China.

Iron overload is a common pathophysiological state underlying many diseases that has a detrimental influence on cells. The protective effects of Dexmedetomidine (Dex), a high selective alpha-2-adrenoceptor agonist, have been revealed through many experimental models, whereas no study reports its effects on an iron overload model. To elucidate these effects, we used FeCl with or without Dex to treat SH-SY5Y cells for 24 h and then detected indicators of oxidative stress, inflammation and apoptosis and investigated possible mechanisms further. Read More

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http://dx.doi.org/10.1007/s11064-019-02731-6DOI Listing
January 2019
1 Read

Resistin-Inhibited Neural Stem Cell-Derived Astrocyte Differentiation Contributes to Permeability Destruction of the Blood-Brain Barrier.

Neurochem Res 2019 Jan 28. Epub 2019 Jan 28.

Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Key Laboratory of Medical Cell Biology, Ministry of Education, Ministry of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China.

Neuroinflammation is an important part of the development of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's and amyotrophic lateral sclerosis. Inflammatory factors destroy the balance of the microenvironment, which results in changes in neural stem cell differentiation and proliferation behaviour. However, the mechanism underlying inflammatory factor-induced NSC behavioural changes is not clear. Read More

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http://dx.doi.org/10.1007/s11064-019-02726-3DOI Listing
January 2019
1 Read

3-Mercapto-5H-1,2,4-Triazino[5,6-b]Indole-5-Acetic Acid (Cemtirestat) Alleviates Symptoms of Peripheral Diabetic Neuropathy in Zucker Diabetic Fatty (ZDF) Rats: A Role of Aldose Reductase.

Neurochem Res 2019 Jan 28. Epub 2019 Jan 28.

Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 84104, Bratislava, Slovakia.

Peripheral neuropathy is the most prevalent chronic complication of diabetes mellitus. Good glycemic control can delay the appearance of neuropathic symptoms in diabetic patients but it is not sufficient to prevent or cure the disease. Therefore therapeutic approaches should focus on attenuation of pathogenetic mechanisms responsible for the nerve injury. Read More

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http://dx.doi.org/10.1007/s11064-019-02736-1DOI Listing
January 2019
3 Reads

Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests.

Neurochem Res 2019 Jan 28. Epub 2019 Jan 28.

Department of Animal Physiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland.

Pterostilbene (PTE), a natural dimethylated analog of resveratrol, possesses numerous health-beneficial properties. The ability of PTE to cross the blood-brain barrier raised the possibility that this compound may modulate central nervous system functions, including seizure activity. The aim of our study was to investigate the activity of PTE in the larval zebrafish pentylenetetrazole (PTZ) seizure assay and three acute seizure tests in mice, i. Read More

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http://dx.doi.org/10.1007/s11064-019-02735-2DOI Listing
January 2019

The Administration of Cadmium for 2, 3 and 4 Months Causes a Loss of Recognition Memory, Promotes Neuronal Hypotrophy and Apoptosis in the Hippocampus of Rats.

Neurochem Res 2019 Feb 23;44(2):485-497. Epub 2019 Jan 23.

Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Pue., Mexico.

Cadmium (Cd) is a toxic metal and classified as a carcinogen whose exposure could affect the function of the central nervous system. There are studies that suggest that Cd promotes neurodegeneration in different regions of the brain, particularly in the hippocampus. It is proposed that its mechanism of toxicity maybe by an oxidative stress pathway, which modifies neuronal morphology and causes the death of neurons and consequently affecting cognitive tasks. Read More

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http://dx.doi.org/10.1007/s11064-018-02703-2DOI Listing
February 2019
2 Reads

Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission.

Neurochem Res 2019 Feb 21;44(2):472-484. Epub 2019 Jan 21.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.

Neuroinflammation and imbalance of neurotransmitters play pivotal roles in seizures and epileptogenesis. Aucubin (AU) is an iridoid glycoside derived from Eucommia ulmoides that possesses anti-inflammatory and neuroprotective effects. However, the anti-seizure effects of AU have not been reported so far. Read More

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http://dx.doi.org/10.1007/s11064-018-2700-yDOI Listing
February 2019
1 Read

Multi-targeted Effect of Nicotinamide Mononucleotide on Brain Bioenergetic Metabolism.

Neurochem Res 2019 Jan 19. Epub 2019 Jan 19.

Veterans Affairs Maryland Health Care System, 10 North Greene Street, Baltimore, MD, 21201, USA.

Dysfunctions in NAD metabolism are associated with neurodegenerative diseases, acute brain injury, diabetes, and aging. Loss of NAD levels results in impairment of mitochondria function, which leads to failure of essential metabolic processes. Strategies to replenish depleted NAD pools can offer significant improvements of pathologic states. Read More

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http://dx.doi.org/10.1007/s11064-019-02729-0DOI Listing
January 2019
1 Read

Effects of Treadmill Exercise on Motor and Cognitive Function Recovery of MCAO Mice Through the Caveolin-1/VEGF Signaling Pathway in Ischemic Penumbra.

Neurochem Res 2019 Jan 19. Epub 2019 Jan 19.

Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.

Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the improvement of synaptic plasticity following moderate exercise are conducive to functional recovery after ischemic damage. Our previous studies have confirmed the angiogenesis and neurogenesis through the caveolin-1/VEGF pathway in MCAO rats. Read More

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http://link.springer.com/10.1007/s11064-019-02728-1
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http://dx.doi.org/10.1007/s11064-019-02728-1DOI Listing
January 2019
4 Reads

The Effect of Mating and the Male Sex Peptide on Group Behaviour of Post-mated Female Drosophila melanogaster.

Authors:
R Elwyn Isaac

Neurochem Res 2019 Jan 19. Epub 2019 Jan 19.

School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.

Sleep is a highly conserved state in animals, but its regulation and physiological function is poorly understood. Drosophila melanogaster is an excellent model for studying sleep regulation and has been used to investigate how sex and social interactions can influence wake-sleep profiles. Previously we have shown that copulation has a profound effect on day time activity and quiescence (siesta sleep) of individual post-mated females. Read More

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http://dx.doi.org/10.1007/s11064-019-02722-7DOI Listing
January 2019

Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial-Astrocytic Crosstalk.

Neurochem Res 2019 Jan 19. Epub 2019 Jan 19.

The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3051, Australia.

Traumatic brain injury triggers neuroinflammation that may contribute to progressive neurodegeneration. We investigated patterns of recruitment of astrocytes and microglia to inflammation after brain trauma by firstly characterising expression profiles over time of marker genes following TBI, and secondly by monitoring glial morphologies reflecting inflammatory responses in a rat model of traumatic brain injury (i.e. Read More

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http://link.springer.com/10.1007/s11064-019-02721-8
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http://dx.doi.org/10.1007/s11064-019-02721-8DOI Listing
January 2019
9 Reads

Atypical Auditory Brainstem Response and Protein Expression Aberrations Related to ASD and Hearing Loss in the Adnp Haploinsufficient Mouse Brain.

Neurochem Res 2019 Jan 18. Epub 2019 Jan 18.

The Lily and Avrahamo Gildor Chair for the Investigation of Growth Factors; The Elton Laboratory for Neuroendocrinology; Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, 69978, Tel Aviv, Israel.

Autism is a wide spread neurodevelopmental disorder with growing morbidity rates, affecting more boys than girls worldwide. Activity-dependent neuroprotective protein (ADNP) was recently recognized as a leading gene accounted for 0.17% of autism spectrum disorder (ASD) cases globally. Read More

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http://dx.doi.org/10.1007/s11064-019-02723-6DOI Listing
January 2019
2 Reads

Dopamine Alters Lipopolysaccharide-Induced Nitric Oxide Production in Microglial Cells via Activation of D1-Like Receptors.

Neurochem Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Immunology and Pathogenic Biology, College of Basic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.

Dopamine (DA) is important in the maintenance of normal nervous system function. DA is the target of multiple drugs, and it induces critical alterations in immune cells. However, these impacts are controversial, and the mechanism remains unclear. Read More

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http://dx.doi.org/10.1007/s11064-019-02730-7DOI Listing
January 2019
3 Reads

Effects of Anesthetic Ketamine on Anxiety-Like Behaviour in Rats.

Neurochem Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110, Ioannina, Greece.

There is scarce information regarding the effects of anesthetic doses of the non-competitive N-methyl-D-aspartate receptor antagonist ketamine on anxiety. The current study evaluated the acute effects of intraperitoneally (i.p. Read More

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http://dx.doi.org/10.1007/s11064-018-02715-yDOI Listing
January 2019

Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats.

Neurochem Res 2019 Jan 17. Epub 2019 Jan 17.

Laboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, 15131-38111, Semnan, Iran.

Increasing evidence suggests that exposure to chronic stress during adolescent period may lead to behavioral and neuronal morphology deficits in adulthood. This study examined whether crocin, the main active saffron constituent, and voluntary exercise, alone or combined, could prevent the detrimental influences of chronic restraint stress during adolescent (postnatal days, PND, 30-40) on behavioral and morphological deficits in adult (PND60) male rats. Results showed that plasma corticosterone levels increased at PND40, but not PND60 in stressed rats. Read More

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http://link.springer.com/10.1007/s11064-019-02727-2
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http://dx.doi.org/10.1007/s11064-019-02727-2DOI Listing
January 2019
15 Reads
2.593 Impact Factor

Neuropeptide VGF-Derived Peptide LQEQ-19 has Neuroprotective Effects in an In Vitro Model of Amyotrophic Lateral Sclerosis.

Neurochem Res 2019 Jan 17. Epub 2019 Jan 17.

Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease caused by the loss of upper and lower motor neurons resulting in muscle weakness and paralysis. Recently, VGF, a neuropeptide that is a precursor of bioactive polypeptides, was found to be decreased in ALS patients, and its inducer exerted protective effects in models of ALS. These findings suggested that VGF was involved in the pathology of ALS. Read More

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http://link.springer.com/10.1007/s11064-019-02725-4
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http://dx.doi.org/10.1007/s11064-019-02725-4DOI Listing
January 2019
12 Reads

Carvacrol Depends on Heme Oxygenase-1 (HO-1) to Exert Antioxidant, Anti-inflammatory, and Mitochondria-Related Protection in the Human Neuroblastoma SH-SY5Y Cells Line Exposed to Hydrogen Peroxide.

Neurochem Res 2019 Jan 16. Epub 2019 Jan 16.

Grupo de Estudos em Neuroquímica e Neurobiologia de Moléculas Bioativas, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Cuiaba, MT, CEP 78060-900, Brazil.

The link between mitochondrial dysfunction, redox impairment, and inflammation leads to increased rates of brain cells loss in neurodegenerative diseases and in affective disorders. Carvacrol (CAR) is a component of essential oils found in Labiatae. CAR exerts antioxidant and anti-inflammatory effects in different cell types, as assessed in both in vitro and in vivo experimental designs. Read More

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http://dx.doi.org/10.1007/s11064-019-02724-5DOI Listing
January 2019
1 Read

Correction to: Isoliquiritigenin Provides Protection and Attenuates Oxidative Stress-Induced Injuries via the Nrf2-ARE Signaling Pathway After Traumatic Brain Injury.

Neurochem Res 2019 Feb;44(2):510-511

Department of Emergency, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, China.

The original version of this article unfortunately contained a mistake. The Fluorescence Immunoassays text written in Materials and Methods section and Fig. 1i, j is incorrect. Read More

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http://dx.doi.org/10.1007/s11064-019-02718-3DOI Listing
February 2019
2.593 Impact Factor

Selective 14-3-3γ Upregulation Promotes Beclin-1-LC3-Autophagic Influx via β-Catenin Interaction in Starved Neurons In Vitro and In Vivo.

Neurochem Res 2019 Jan 11. Epub 2019 Jan 11.

Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, China.

Lack of blood or glucose supply is the most common pathological factor in the brain. To cope with such an energy stress, initiating programmed autophagic processes in neurons is required. However, the mechanisms controlling neuronal autophagy during starvation remain far from clear. Read More

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http://link.springer.com/10.1007/s11064-019-02717-4
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http://dx.doi.org/10.1007/s11064-019-02717-4DOI Listing
January 2019
4 Reads

Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats.

Neurochem Res 2019 Jan 10. Epub 2019 Jan 10.

Department of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul, 07985, Republic of Korea.

The effect of 3, 4, 5-trimethoxy cinnamic acid (TMCA) against morphine-induced dependence in mice and rats was investigated. Mice were pretreated with TMCA and then morphine was injected intraperitoneally; whereas rats were treated with TMCA (i.p. Read More

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http://link.springer.com/10.1007/s11064-019-02720-9
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http://dx.doi.org/10.1007/s11064-019-02720-9DOI Listing
January 2019
3 Reads

Chronic Sleep Restriction Induces Aβ Accumulation by Disrupting the Balance of Aβ Production and Clearance in Rats.

Neurochem Res 2019 Jan 10. Epub 2019 Jan 10.

Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Rd, 710061, Xi'an, China.

Amyloid-β (Aβ) plays an important role in Alzheimer's disease (AD) pathogenesis, and growing evidence has shown that poor sleep quality is one of the risk factors for AD, but the mechanisms of sleep deprivation leading to AD have still not been fully demonstrated. In the present study, we used wild-type (WT) rats to determine the effects of chronic sleep restriction (CSR) on Aβ accumulation. We found that CSR-21d rats had learning and memory functional decline in the Morris water maze (MWM) test. Read More

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http://link.springer.com/10.1007/s11064-019-02719-2
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http://dx.doi.org/10.1007/s11064-019-02719-2DOI Listing
January 2019
5 Reads

Long-term Therapeutic Effects of Extracorporeal Shock Wave-Assisted Melatonin Therapy on Mononeuropathic Pain in Rats.

Neurochem Res 2019 Jan 10. Epub 2019 Jan 10.

Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123, Dapi Rd., Niaosong Dist, Kaohsiung, 83301, Taiwan.

We evaluated the ability of extracorporeal shock wave (ECSW)-assisted melatonin (Mel) therapy to offer an additional benefit for alleviating the neuropathic pain (NP) in rats. Left sciatic nerve was subjected to chronic constriction injury (CCI) to induce NP. Animals (n = 30) were randomized into group 1 (sham-operated control), group 2 (CCI only), group 3 (CCI + ECSW), group 4 (CCI + Mel) and group 5 (CCI + ECSW + Mel). Read More

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http://link.springer.com/10.1007/s11064-018-02713-0
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http://dx.doi.org/10.1007/s11064-018-02713-0DOI Listing
January 2019
3 Reads

MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway.

Neurochem Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an, 710032, China.

MicroRNA-124 (miR-124) is a brain specific miRNA that is highly expressed in microglia. The upregulation of miR-124 contributes to M2 polarization of microglia, which is beneficial to neurogenesis. Exosomes are lipid membrane vesicles that can deliver miR-124 into the brain. Read More

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http://link.springer.com/10.1007/s11064-018-02714-z
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http://dx.doi.org/10.1007/s11064-018-02714-zDOI Listing
January 2019
6 Reads

Glutamate Transporters: Expression and Function in Oligodendrocytes.

Neurochem Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Box 980709, Richmond, VA, 23298, USA.

Glutamate, the main excitatory neurotransmitter of the vertebrate central nervous system (CNS), is well known as a regulator of neuronal plasticity and neurodevelopment. Such glutamate function is thought to be mediated primarily by signaling through glutamate receptors. Thus, it requires a tight regulation of extracellular glutamate levels and a fine-tuned homeostasis that, when dysregulated, has been associated with a wide range of central pathologies including neuropsychiatric, neurodevelopmental, and neurodegenerative disorders. Read More

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http://dx.doi.org/10.1007/s11064-018-02708-xDOI Listing
January 2019

Nrf2/ARE Pathway as a Therapeutic Target for the Treatment of Parkinson Diseases.

Neurochem Res 2019 Jan 7. Epub 2019 Jan 7.

Department of Genetics, Cytology and Bioengineering, Voronezh State University, Voronezh, Russia.

Instead of the progress in the understanding of etiology of Parkinson's disease (PD), effective methods to prevent the progression of the disease have not been developed and only symptomatic treatment is currently possible. One of possible pathways to slow the progression of the disease is protection of dopaminergic neurons by maintaining mitochondrial quality control in neuron cells. Recent studies showed that the most promising target for pharmacological effects on mitochondria is the Nrf2/ARE signaling cascade. Read More

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http://link.springer.com/10.1007/s11064-018-02711-2
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http://dx.doi.org/10.1007/s11064-018-02711-2DOI Listing
January 2019
6 Reads

Cinnamic Acid Protects the Nigrostriatum in a Mouse Model of Parkinson's Disease via Peroxisome Proliferator-Activated Receptorα.

Neurochem Res 2019 Jan 5. Epub 2019 Jan 5.

Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, USA.

Parkinson's disease (PD) is the second most common devastating human neurodegenerative disorder and despite intense investigation, no effective therapy is available for PD. Cinnamic acid, a naturally occurring aromatic fatty acid of low toxicity, is a precursor for the synthesis of a huge number of plant substances. This study highlights the neuroprotective effect of cinnamic acid in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. Read More

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http://dx.doi.org/10.1007/s11064-018-02705-0DOI Listing
January 2019

Caffeine Neuroprotection Decreases A2A Adenosine Receptor Content in Aged Mice.

Neurochem Res 2019 Jan 4. Epub 2019 Jan 4.

Programa de Pós-graduação em Nanociências, Centro Universitário Franciscano -UNIFRA, Ruas dos Andradas, 1614, Santa Maria, RS, Brazil.

Caffeine is a bioactive compound worldwide consumed with effect into the brain. Part of its action in reducing incidence or delaying Alzheimer's and Parkinson's diseases symptoms in human is credited to the adenosine receptors properties. However, the impact of caffeine consumption during aging on survival of brain cells remains debatable. Read More

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http://dx.doi.org/10.1007/s11064-018-02710-3DOI Listing
January 2019
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Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors.

Neurochem Res 2019 Jan 4. Epub 2019 Jan 4.

Department of Anatomy, Yonsei University College of Medicine, 50-1 Yonsei-Ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any acute or chronic, central or peripheral neurological disorder is related to abnormal biochemical and electrical signals in the brain cells. As a result, ion channels and receptors that are abundant in the nervous system and control the electrical and biochemical environment of the CNS play a vital role in neurological disease. Read More

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http://link.springer.com/10.1007/s11064-018-02712-1
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http://dx.doi.org/10.1007/s11064-018-02712-1DOI Listing
January 2019
7 Reads

Juvenile Rats Show Altered Gut Microbiota After Exposure to Isoflurane as Neonates.

Neurochem Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Anesthesiology, Peking University School and Hospital of Stomatology, #22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, China.

Inhaled anesthetic agents may be neurotoxic to the developing brain of a neonatal rodent. Isoflurane is a commonly used volatile anesthetic agent for maintenance of general anesthesia in various types of surgery. Neonatal exposure to isoflurane has been implicated in long-term neurocognitive dysfunction in children. Read More

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http://link.springer.com/10.1007/s11064-018-02707-y
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http://dx.doi.org/10.1007/s11064-018-02707-yDOI Listing
January 2019
1 Read

Sinomenine Attenuates Traumatic Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation via Nrf2 Pathway.

Neurochem Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.

Traumatic spinal cord injury (SCI) is a devastating condition with few efficacious drugs. Sinomenine, a bioactive alkaloid extracted from medicinal herb, has been used as a treatment of rheumatoid diseases. This present study explored the therapeutic effects of sinomenine on locomotor dysfunction and neuropathology in SCI. Read More

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http://dx.doi.org/10.1007/s11064-018-02706-zDOI Listing
January 2019
1 Read

Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils.

Neurochem Res 2019 Jan 2. Epub 2019 Jan 2.

Institute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd, Nankang, Taipei, 11529, Taiwan.

Prion diseases are transmissible fatal neurodegenerative disorders affecting humans and other mammals. The disease transmission can occur between different species but is limited by the sequence homology between host and inoculum. The crucial molecular event in the progression of this disease is prion formation, starting from the conformational conversion of the normal, membrane-anchored prion protein (PrP) into the misfolded, β-sheet-rich and aggregation-prone isoform (PrP), which then self-associates into the infectious amyloid form called prion. Read More

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http://dx.doi.org/10.1007/s11064-018-02709-wDOI Listing
January 2019
1 Read

Electroacupuncture and Curcumin Promote Oxidative Balance and Motor Function Recovery in Rats Following Traumatic Spinal Cord Injury.

Neurochem Res 2019 Feb 2;44(2):498-506. Epub 2019 Jan 2.

UAM Iztapalapa, C.P. 09340, México City, Mexico.

Spinal cord injury (SCI) is a condition that puts the patient's life at risk in the acute phase and, during the chronic stage, results in permanent deficits in motor, sensory and autonomic functions. Isolated therapeutic strategies have not shown an effect on this condition. Therefore, this study aimed to evaluate the effects of electroacupuncture (EA) and curcumin, alone or combined, on the oxidative balance, motor function recovery and amount of preserved tissue following a traumatic SCI. Read More

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http://dx.doi.org/10.1007/s11064-018-02704-1DOI Listing
February 2019

Special Issue in Honor of Dr. Elias K. Michaelis.

Neurochem Res 2019 Jan 2;44(1):1-4. Epub 2019 Jan 2.

University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s11064-018-02702-3DOI Listing
January 2019

Scalable Measurements of Intrinsic Excitability in Human iPS Cell-Derived Excitatory Neurons Using All-Optical Electrophysiology.

Neurochem Res 2019 Jan 2. Epub 2019 Jan 2.

Q-State Biosciences, 179 Sidney Street, Cambridge, MA, 02139, USA.

Induced pluripotent stem (iPS) cells offer the exciting opportunity for modeling neurological disorders in vitro in the context of a human genetic background. While significant progress has been made in advancing the use of iPS cell-based disease models, there remains an unmet need to characterize the electrophysiological profile of individual neurons with sufficient throughput to enable statistically robust assessment of disease phenotypes and pharmacological modulation. Here, we describe the Optopatch platform technology that utilizes optogenetics to both stimulate and record action potentials (APs) from human iPS cell-derived excitatory neurons with similar information content to manual patch clamp electrophysiology, but with ~  3 orders of magnitude greater throughput. Read More

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http://dx.doi.org/10.1007/s11064-018-2694-5DOI Listing
January 2019

Human Remyelination Promoting Antibody Stimulates Astrocytes Proliferation Through Modulation of the Sphingolipid Rheostat in Primary Rat Mixed Glial Cultures.

Neurochem Res 2018 Dec 19. Epub 2018 Dec 19.

Department of Medical Biotechnology and Translational Medicine, University of Milan, Via Fratelli Cervi 93, Segrate, 20090, Milan, Italy.

Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether they are directly targeting OLs, or their action is mediated by effects on other cell types. We assessed the effect of remyelination promoting antibody rHIgM22 on the proliferative response and on the ceramide/sphingosine 1-phosphate rheostat in mixed glial cell cultures (MGCs). Read More

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http://dx.doi.org/10.1007/s11064-018-2701-xDOI Listing
December 2018

Suberoylanilide Hydroxamic Acid Triggers Autophagy by Influencing the mTOR Pathway in the Spinal Dorsal Horn in a Rat Neuropathic Pain Model.

Neurochem Res 2019 Feb 17;44(2):450-464. Epub 2018 Dec 17.

Department of Anesthesiology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Rd, Wuhan, 430071, Hubei, China.

Histone acetylation levels can be upregulated by treating cells with histone deacetylase inhibitors (HDACIs), which can induce autophagy. Autophagy flux in the spinal cord of rats following the left fifth lumber spinal nerve ligation (SNL) is involved in the progression of neuropathic pain. Suberoylanilide hydroxamic acid (SAHA), one of the HDACIs can interfere with the epigenetic process of histone acetylation, which has been shown to ease neuropathic pain. Read More

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http://dx.doi.org/10.1007/s11064-018-2698-1DOI Listing
February 2019