3,734 results match your criteria Neuroblastoma Imaging


Upconversion nanoparticles as intracellular pH messengers.

Anal Bioanal Chem 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Dr., Cambridge, CB3 0AS, UK.

Upconversion nanoparticles (UCNPs) should be particularly well suited for measurement inside cells because they can be imaged down to submicrometer dimensions in near real time using fluorescence microscopy, and they overcome problems, such as photobleaching, autofluorescence, and deep tissue penetration, that are commonly encountered in cellular imaging applications. In this study, the performance of an UCNP modified with a pH-sensitive dye (pHAb) is studied. The dye (emission wavelength 580 nm) was attached in a polyethylene imine (PEI) coating on the UCNP and excited via the 540-nm UCNP emission under 980-nm excitation. Read More

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http://dx.doi.org/10.1007/s00216-020-02768-5DOI Listing

Noninvasive MRI native T1 mapping detects response to MYCN-targeted therapies in the Th-MYCN model of neuroblastoma.

Cancer Res 2020 Jun 28. Epub 2020 Jun 28.

Division of Radiotherapy and Imaging, The Institute of Cancer Research, London

Noninvasive early indicators of treatment response are crucial to the successful delivery of precision medicine in children with cancer. Neuroblastoma is a common solid tumor of young children that arises from anomalies in neural crest development. Therapeutic approaches aiming to destabilize MYCN protein, such as small molecule inhibitors of Aurora A and mTOR, are currently being evaluated in early phase clinical trials in children with high-risk MYCN-driven disease, with limited ability to evaluate conventional pharmacodynamic biomarkers of response. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-20-0133DOI Listing

MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma.

Oncotarget 2020 Jun 9;11(23):2141-2159. Epub 2020 Jun 9.

Academic Unit of Molecular Oncology, Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

This study investigates the influence expression of the MYCN oncogene has on the DNA damage response, replication fork progression and sensitivity to PARP inhibition in neuroblastoma. In a panel of neuroblastoma cell lines, amplification or MYCN expression resulted in increased cell death in response to a range of PARP inhibitors (niraparib, veliparib, talazoparib and olaparib) compared to the response seen in non-expressing/amplified cells. MYCN expression slowed replication fork speed and increased replication fork stalling, an effect that was amplified by PARP inhibition or PARP1 depletion. Read More

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http://dx.doi.org/10.18632/oncotarget.27329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289530PMC

Pediatric radiation enteritis with intestinal failure: A case report and literature review.

Medicine (Baltimore) 2020 Jun;99(25):e20905

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province, China.

Rationale: Chronic radiation enteritis, a disease secondary to radiation exposure, has been widely reported in adults. However, few studies have described chronic radiation enteritis in children. Early diagnosis is essential, and nutrition management plays an important role in pediatric chronic radiation enteritis management. Read More

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http://dx.doi.org/10.1097/MD.0000000000020905DOI Listing

68Ga-DOTATATE and 18F-FDG PET/CT for the Management of Esthesioneuroblastoma of the Sphenoclival Region.

Clin Nucl Med 2020 Aug;45(8):e363-e364

The Persian Gulf Nuclear Medicine Research Center, Department of Molecular Imaging and Radionuclide Therapy, Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr, Iran.

We present a 48-year-old woman with an olfactory neuroblastoma who was referred for accurate staging using PET/CT. The Ga-DOTATATE PET/CT showed a 51 × 32-mm mass with an SUVmax of 7.59 in the sphenoidal sinuses, whereas radiotracer uptake on F-FDG PET/CT was similar to that of brain tissue. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003133DOI Listing

Surgical outcomes in patients with endoscopic versus transcranial approach for skull base malignancies: a 10-year institutional experience.

Br J Neurosurg 2020 Jun 15:1-7. Epub 2020 Jun 15.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

The authors performed an extensive comparison between patients treated with open versus an endoscopic approach for skull base malignancy with emphasis on surgical outcomes. A single-institution retrospective review of 60 patients who underwent surgery for skull base malignancy between 2009 and 2018 was performed. Disease features, surgical resection, post-operative morbidities, adjuvant treatment, recurrence, and survival rates were compared between 30 patients who received purely open surgery and 30 patients who underwent purely endoscopic resection for a skull base malignancy. Read More

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http://dx.doi.org/10.1080/02688697.2020.1779659DOI Listing
June 2020
0.947 Impact Factor

The risk of a serious etiology in pediatric Horner syndrome: indications for a workup and which investigations to perform.

J AAPOS 2020 Jun 6. Epub 2020 Jun 6.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Purpose: To report the risk of a serious etiology in a cohort of children with Horner syndrome without a known cause at presentation.

Methods: The medical records of children (<18 years of age) with Horner syndrome of unknown etiology who underwent a workup at a single tertiary-care pediatric hospital over a 20-year period were reviewed retrospectively.

Results: A total of 48 patients with Horner syndrome were included. Read More

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http://dx.doi.org/10.1016/j.jaapos.2020.02.012DOI Listing

Roles of PET/Computed Tomography in the Evaluation of Neuroblastoma.

PET Clin 2020 Jul;15(3):321-331

Department of Radiology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

Neuroblastoma is one of the most common pediatric malignant tumors. Functional imaging plays an important role in the diagnosis, staging, and therapy response monitoring of neuroblastoma. Although metaiodobenzylguanidine scan with single-photon emission computed tomography/computed tomography remains the mainstay in functional imaging of the neuroblastomas, PET/CT has begun to show increased utility in this clinical setting. Read More

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http://dx.doi.org/10.1016/j.cpet.2020.03.003DOI Listing

Pediatric applications of Dotatate: early diagnostic and therapeutic experience.

Pediatr Radiol 2020 Jun 3;50(7):882-897. Epub 2020 Jun 3.

Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

In recent years, new somatostatin receptor agents (SSTRs) have become available for diagnostic imaging and therapy in neuroendocrine tumors. The novel SSTR ligand DOTA-DPhel-Tyr3-octreotate (Dotatate) in particular can be linked with Gallium for diagnostic imaging purposes, and with the β-emitter Lutetium for radiotherapy in the setting of neuroendocrine tumors. Dotatate imaging offers distinct advantages in the evaluation of neuroendocrine tumors compared to standard techniques, including greater target-to-background ratio and lesion conspicuity, high sensitivity/specificity, improved spatial resolution with positron emission tomography (PET)/CT or PET/MR, and decreased radiation exposure. Read More

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http://dx.doi.org/10.1007/s00247-020-04688-zDOI Listing

Mixed olfactory neuroblastoma and neuroendocrine carcinoma: An unusual case report and literature review.

Surg Neurol Int 2020 9;11:97. Epub 2020 May 9.

Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Medical Center, California, USA.

Background: The aim of the study was to present a case of mixed olfactory neuroblastoma (ONB) and carcinoma, an extremely rare tumor with only a few cases in the published literature.

Case Description: An otherwise healthy 27-year-old male presented with sinus complaints, headache, and unilateral eye discharge. Imaging and endoscopy revealed a mass presumed to represent a juvenile nasopharyngeal angiofibroma. Read More

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http://dx.doi.org/10.25259/SNI_473_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265421PMC

Posterior Reversible Encephalopathy Syndrome Mimicking Tumor Recurrence in a Patient With Multiply Recurrent Neuroblastoma.

Pediatr Neurol 2020 Apr 28. Epub 2020 Apr 28.

Department of Neurosciences and Pediatrics, University of California San Diego, La Jolla, Rady Children's Hospital, San Diego, California. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2020.04.015DOI Listing

Theragnostic Aspects and Radioimmunotherapy in Pediatric Tumors.

Int J Mol Sci 2020 May 28;21(11). Epub 2020 May 28.

Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, Italy.

The use of theragnostic radiopharmaceuticals in nuclear medicine has grown rapidly over the years to combine the diagnosis and therapy of tumors. In this review, we performed web-based and desktop literature research to investigate and explain the potential role of theragnostic imaging in pediatric oncology. We focused primarily on patients with aggressive malignancies such as neuroblastoma and brain tumors, to select patients with the highest chance of benefit from personalized therapy. Read More

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http://dx.doi.org/10.3390/ijms21113849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312954PMC

Superior Synaptogenic Effect of Electrospun PLGA-PEG Nanofibers Versus PLGA Nanofibers on Human Neural SH-SY5Y Cells in a Three-Dimensional Culture System.

J Mol Neurosci 2020 May 21. Epub 2020 May 21.

Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Synapses are touted as the main structural and functional components of neural cells within in the nervous system, providing tissue connectivity and integration via the formation of perineuronal nets. In the present study, we evaluated the synaptogenic activity of electrospun PLGA and PLGA-PEG nanofibers on human SH-SY5Y cells after 14 days in vitro. Electrospun PLGA and PLGA-PEG nanofibers were fabricated and physicochemical properties were examined using the HNMR technique. Read More

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http://dx.doi.org/10.1007/s12031-020-01596-7DOI Listing
May 2020
2.343 Impact Factor

Mechanisms of Efficacy of the FGFR1-3 Inhibitor AZD4547 in Pediatric Solid Tumor Models.

Invest New Drugs 2020 May 20. Epub 2020 May 20.

Department of Pediatrics, Division of Hematology-Oncology, University of California San Diego, 3855 Health Sciences Dr., MC 0815, La Jolla, CA, 92093, USA.

Children with aggressive pediatric solid tumors have poor outcomes and novel treatments are needed. Pediatric solid tumors demonstrate aberrant expression and activity of the fibroblast growth factor receptor (FGFR) family, suggesting FGFR inhibitors may be effective therapeutic agents. AZD4547 is a multikinase inhibitor of the FGFR1-3 kinases, and we hypothesized that AZD4547 would be effective in pediatric solid tumor preclinical models. Read More

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http://dx.doi.org/10.1007/s10637-020-00933-2DOI Listing

A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors.

Cancer Med 2020 May 19. Epub 2020 May 19.

Centre for Reviews and Dissemination, University of York, York, UK.

Background: Regular off-treatment imaging is often used to assess for recurrence of disease after childhood cancer treatment. It is unclear if this increases survival, or what burden surveillance places on patients, families, or health-care services. This systematic review examines the impact of routine surveillance imaging after treatment of pediatric extracranial solid tumors. Read More

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http://dx.doi.org/10.1002/cam4.3110DOI Listing

[Pt(O,O'-acac)(γ-acac)(DMS)]: Alternative Strategies to Overcome Cisplatin-Induced Side Effects and Resistance in T98G Glioma Cells.

Cell Mol Neurobiol 2020 May 19. Epub 2020 May 19.

Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology ''L. Spallanzani'', University of Pavia, via Ferrata 9, 27100, Pavia, Italy.

Cisplatin (CDDP) is one of the most effective chemotherapeutic agents, used for the treatment of diverse tumors, including neuroblastoma and glioblastoma. CDDP induces cell death through different apoptotic pathways. Despite its clinical benefits, CDDP causes several side effects and drug resistance. Read More

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http://dx.doi.org/10.1007/s10571-020-00873-8DOI Listing

Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase.

J Neurooncol 2020 May 18. Epub 2020 May 18.

Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

Introduction: Sinonasal tumors that harbor neuroendocrine histologic features include olfactory neuroblastoma (previously known as esthesioneuroblastoma), sinonasal neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma. These tumors represent a diverse spectrum of clinical behavior and as such require histology-specific management. Herein, we review the management of these sinonasal tumors with neuroendocrine features and discuss fundamentals of multi-modality care for each histology. Read More

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http://dx.doi.org/10.1007/s11060-020-03537-1DOI Listing

Bone marrow involvement in pediatric malignancies: a comparison study of Positron emission tomographycomputed tomography and bone marrow biopsy.

Turk J Pediatr 2020 ;62(2):182-190

Departments of Pediatrics, Mersin University Faculty of Medicine, Mersin, Turkey.

Background And Objectives: The comparison of Positron emission tomography- computed tomography (PETCT) and bone marrow biopsy (BMB) modalities in detecting bone marrow disease is an up to date research topic. In this study, we aimed to compare the results of PET-CT and BMB procedures in detecting bone marrow involvement in pediatric malignancies.

Method: At the time of diagnosis, PET-CT imaging and BMB performed patients` data were evaluated, retrospectively. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.003DOI Listing
January 2020

A feasibility study for noninvasive measurement of shear wave speed in live zebrafish.

Ultrasonics 2020 Sep 11;107:106170. Epub 2020 May 11.

Department of Biochemistry and Molecular Biology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Zebrafish are being increasingly used as animal models for human diseases such as cardiomyopathy and neuroblastoma. Owing to a nearly fully sequenced genome and efficient genetics/chemical genetics, zebrafish open new research opportunities for human diseases research. The purpose of this study was to develop zebrafish ultrasound vibro-elastography (ZUVE) for measuring the shear wave speed of zebrafish. Read More

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http://dx.doi.org/10.1016/j.ultras.2020.106170DOI Listing
September 2020

Molecular imaging of norepinephrine transporter-expressing tumors: current status and future prospects.

Q J Nucl Med Mol Imaging 2020 May 12. Epub 2020 May 12.

Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium -

The human norepinephrine transporter (hNET) is a transmembrane protein responsible for reuptake of norepinephrine in presynaptic sympathetic nerve terminals and adrenal chromaffin cells. Neural crest tumors, such as neuroblastoma, paraganglioma and pheochromocytoma often show high hNET expression. Molecular imaging of these tumors can be done using radiolabeled norepinephrine analogs that target hNET. Read More

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http://dx.doi.org/10.23736/S1824-4785.20.03261-6DOI Listing

Compressing gene expression data using multiple latent space dimensionalities learns complementary biological representations.

Genome Biol 2020 May 11;21(1):109. Epub 2020 May 11.

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, 10-131 SCTR 34th and Civic Center Blvd, Philadelphia, PA, 19104, USA.

Background: Unsupervised compression algorithms applied to gene expression data extract latent or hidden signals representing technical and biological sources of variation. However, these algorithms require a user to select a biologically appropriate latent space dimensionality. In practice, most researchers fit a single algorithm and latent dimensionality. Read More

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http://dx.doi.org/10.1186/s13059-020-02021-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212571PMC

Novel therapeutic strategies targeting telomere maintenance mechanisms in high-risk neuroblastoma.

J Exp Clin Cancer Res 2020 May 6;39(1):78. Epub 2020 May 6.

Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, London, UK.

The majority of high-risk neuroblastomas can be divided into three distinct molecular subgroups defined by the presence of MYCN amplification, upstream TERT rearrangements or alternative lengthening of telomeres (ALT). The common defining feature of all three subgroups is altered telomere maintenance; MYCN amplification and upstream TERT rearrangements drive high levels of telomerase expression whereas ALT is a telomerase independent telomere maintenance mechanism. As all three telomere maintenance mechanisms are independently associated with poor outcomes, the development of strategies to selectively target either telomerase expressing or ALT cells holds great promise as a therapeutic approach that is applicable to the majority of children with aggressive disease. Read More

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http://dx.doi.org/10.1186/s13046-020-01582-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201617PMC

Tumour-to-tumour metastasis: breast carcinoma to an olfactory neuroblastoma.

Ann R Coll Surg Engl 2020 Jul 6;102(6):e118-e121. Epub 2020 May 6.

Ear, Nose and Throat Department, Royal Surrey County Hospital, Guildford, Surrey, UK.

Tumour-to-tumour metastasis is a rare phenomenon. It occurs when a primary tumour is a recipient of a separate tumour within the same individual. We present a case of a 66-year-old woman with known breast cancer who presented with one-sided nasal symptoms. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0038DOI Listing

First-in-Human Trial of Epichaperome-Targeted Positron Emission Tomography in Cancer Patients.

Clin Cancer Res 2020 May 4. Epub 2020 May 4.

Nuclear Medicine, Memorial Sloan Kettering Cancer Center.

Purpose: I-PU-H71 is an investigational first-in-class radiologic agent specific for imaging tumor epichaperome formations. The intracellular epichaperome forms under cellular stress and is a clinically validated oncotherapeutic target. We conducted a first-in-human study of microdose I-PU-H71 for positron emission tomography (PET) to study biodistribution, pharmacokinetics, metabolism, and safety; and the feasibility of epichaperome-targeted tumor imaging. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3704DOI Listing

Evaluation of toxicity of gadolinium-based contrast agents on neuronal cells.

Acta Radiol 2020 May 4:284185120920801. Epub 2020 May 4.

Department of Physiology, Ege University School of Medicine, Izmir, Turkey.

Background: Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging (MRI). Recently, increased signal intensity has been reported in specific brain areas after repeated administrations of GBCAs.

Purpose: To investigate the toxic effects of GBCAs on neuronal cells by using SH-SY5Y neuroblastoma cell cultures. Read More

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http://dx.doi.org/10.1177/0284185120920801DOI Listing

Hyaluronan-Metal Gold Nanoparticle Hybrids for Targeted Tumor Cell Therapy.

Int J Mol Sci 2020 Apr 27;21(9). Epub 2020 Apr 27.

Nano-Hybrid-BioInterfacesLab (NHBIL), Department of Chemical Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy.

In this study, a novel multifunctional nanoplatform based on core-shell nanoparticles of spherical gold nanoparticles (AuNPs) capped with low and high molecular weight (200 and 700 kDa) hyaluronic acid (HA), was assembled via a green, one-pot redox synthesis method at room temperature. A multitechnique characterization approach by UV-visible spectroscopy, dynamic light scattering and atomic force microscopy pointed to the effective 'surface decoration' of the gold nanoparticles by HA, resulting in different grafting densities of the biopolymer chains at the surface of the metal nanoparticle, which in turn affected the physicochemical properties of the nanoparticles. Specifically, the spectral features of the gold plasmonic peak (and the related calculated optical size), the hydrodynamic diameter and the nanoparticle stability were found to depend on the molecular weight of the HA. Read More

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http://dx.doi.org/10.3390/ijms21093085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247672PMC

Primary sellar neuroblastoma mimicking invasive pituitary adenoma: a systematic review.

J Neurosurg Sci 2020 Apr 29. Epub 2020 Apr 29.

Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University, Dacca, Bangladesh.

Introduction: To report an extremely rare case of sellar neuroblastoma, which mimicked invasive pituitary adenoma with supra- and parasellar extensions, treated through endoscopic endonasal approach. A systematic review of the literature on diagnosis and management of patients affected by sellar neuroblastomas has been performed.

Evidence Acquiition: A literature search according to the PRISMA statement was conducted using MEDLINE, Google Scholar, and EBSCO databases, searching for the following MeSH terms: (sellar OR parasellar OR suprasellar OR sphenoidal) AND (neuroblastoma OR extranasal esthesioneuroblastoma OR central neuroblastoma). Read More

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http://dx.doi.org/10.23736/S0390-5616.20.04931-0DOI Listing

Recent Advances in Pathology: the 2020 Annual Review Issue of The Journal of Pathology.

J Pathol 2020 Apr;250(5):475-479

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

This year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. Read More

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http://dx.doi.org/10.1002/path.5425DOI Listing

ALK Inhibitors-Induced M Phase Delay Contributes to the Suppression of Cell Proliferation.

Cancers (Basel) 2020 Apr 24;12(4). Epub 2020 Apr 24.

Department of Biochemistry & Molecular Biology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.

Anaplastic lymphoma kinase (ALK), a receptor-type tyrosine kinase, is involved in the pathogenesis of several cancers. ALK has been targeted with small molecule inhibitors for the treatment of different cancers, but absolute success remains elusive. In the present study, the effects of ALK inhibitors on M phase progression were evaluated. Read More

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http://dx.doi.org/10.3390/cancers12041054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226408PMC

Sinonasal carcinomas - A single-centre experience at Prince of Wales Hospital, Sydney, Australia, from 1994 to 2016.

J Med Imaging Radiat Oncol 2020 Jun 20;64(3):450-459. Epub 2020 Apr 20.

Department of Radiation Oncology, Prince of Wales Hospital, Sydney, New South Wales, Australia.

Introduction: Sinonasal carcinomas (SNCs) are rare neoplasms that are often diagnosed at advanced stages due to asymptomatic growth of tumours in the spaces of the sinonasal complex. Treatment is associated with high morbidity, and outcomes have only improved slightly in the past few decades despite advancements in treatment modalities. The purpose of this study is to evaluate the efficacy and safety of treatment at our institution. Read More

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http://dx.doi.org/10.1111/1754-9485.13034DOI Listing

Is there a need for pediatric PET/CT camera?

Authors:
Ismet Sarikaya

J Nucl Med Technol 2020 Apr 10. Epub 2020 Apr 10.

Kuwait University, Faculty of Medicine, Mubarak Al-Kabeer Hospital, Kuwait.

Positron emission tomography (PET) imaging is commonly used in adult patients. Its use in pediatric patients is limited but indicated in certain cancers such as lymphoma, sarcoma, neuroblastoma and central nervous system tumors (1). The main limitation of PET imaging is its relatively limited spatial resolution in detecting small lesions which is mainly due to non-collinearity of the 511 keV annihilation photons, positron range, detector scatter, and parallax error (2-5). Read More

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http://dx.doi.org/10.2967/jnmt.119.240713DOI Listing

Neuroprotective Effect of Bergamot Juice in 6-OHDA-Induced SH-SY5Y Cell Death, an Model of Parkinson's Disease.

Pharmaceutics 2020 Apr 5;12(4). Epub 2020 Apr 5.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98100, Italy.

Much evidence suggests that both oxidative stress and apoptosis play a key role in the pathogenesis of Parkinson's disease (PD). The present study aims to evaluate the protective effect of bergamot juice (BJ) against 6-hydroxydopamine (6-OHDA)- or HO-induced cell death. Treatment of differentiated SH-SY5Y human neuroblastoma cells with 6-OHDA or HO resulted in cell death that was significantly reduced by the pre-treatment with BJ. Read More

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http://dx.doi.org/10.3390/pharmaceutics12040326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238189PMC

High-specific-activity iodine 131 metaiodobenzylguanidine for the treatment of metastatic pheochromocytoma or paraganglioma: a novel therapy for an orphan disease.

Curr Opin Endocrinol Diabetes Obes 2020 Jun;27(3):162-169

Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Purpose Of Review: Pheochromocytomas and paragangliomas represent less than 1% of all endocrine tumors. Approximately 15-20% of these tumors are malignant. The definition of malignancy relies on the presence of metastasis. Read More

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http://dx.doi.org/10.1097/MED.0000000000000544DOI Listing

PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers.

Eur Radiol Exp 2020 Apr 3;4(1):22. Epub 2020 Apr 3.

Department of Translational Research, University of Pisa, Chair Radiodiagnostica 3, Pisa University Hospital, Via Roma 67, 56126, Pisa, Italy.

PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children. It is a 4-year European Commission-financed project that has 16 European partners in the consortium, including the European Society for Paediatric Oncology, two imaging biobanks, and three prominent European paediatric oncology units. The project is constructed as an observational in silico study involving high-quality anonymised datasets (imaging, clinical, molecular, and genetics) for the training and validation of machine learning and multiscale algorithms. Read More

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http://dx.doi.org/10.1186/s41747-020-00150-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125275PMC

Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature.

Childs Nerv Syst 2020 Apr 3. Epub 2020 Apr 3.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

Purpose: Intracranial ganglioneuroblastomas are incredibly rare neuroectodermal tumors with only 8 described cases total, 5 of those having imaging findings METHODS: Here we present a 9-year-old female patient with 4 months progressive headaches, personality changes, and vomiting. We also present a review of the current literature of intracranial ganglioneuroblastomas.

Results: Imaging demonstrated a partially calcified suprasellar mass measuring 4. Read More

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http://dx.doi.org/10.1007/s00381-020-04597-4DOI Listing

Effect of (m)RVD-hemopressin against Aβ1-42-induced apoptosis and inhibition of neurite outgrowth in SH-SY5Y cells.

Neuropeptides 2020 Jun 19;81:102044. Epub 2020 Mar 19.

Shaanxi Key Laboratory of Brain Disorders, School of Basic Medical Science, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an 710021, China. Electronic address:

Alzheimer's disease (AD) is a serious neurodegenerative disease. Senile plaques (SPs) in the extracellular space and neurofibrillary tangles (NFTs) in the intracellular areas of the brain are two typical features of AD. SPs and NFTs are composed of amyloid-β (Aβ) aggregates and hyperphosphorylated Tau, respectively. Read More

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http://dx.doi.org/10.1016/j.npep.2020.102044DOI Listing
June 2020
2.546 Impact Factor

Magnetic Resonance Imaging Findings of Bilateral Cystic Neuroblastoma: Case Report of a Very Rare Entity.

Authors:
Esra Özgül

Cureus 2020 Feb 22;12(2):e7073. Epub 2020 Feb 22.

Radiology, Afyonkarahisar Health Science University, Afyonkarahisar, TUR.

Neuroblastoma (NB) is the most common solid tumor seen in children under two years old. It has both solid and cystic forms. It generally involves the adrenal gland unilaterally. Read More

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http://dx.doi.org/10.7759/cureus.7073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093919PMC
February 2020

High-dose I-metaiodobenzylguanidine therapy in patients with high-risk neuroblastoma in Japan.

Ann Nucl Med 2020 Jun 26;34(6):397-406. Epub 2020 Mar 26.

Department of Nuclear Medicine, Kanazawa University Hospital and Department of Nuclear Medicine, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Objective: The aim of the study was to investigate the outcomes and prognostic factors of high-dose I-metaiodobenzylguanidine (I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan.

Methods: We retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwent I-MIBG therapy with an administration dose ranging from 444 to 666 MBq/kg at Kanazawa University Hospital, Japan, between September 2008 and September 2013. We focused on measurements regarding their initial responses, prognostic factors, survivals, and toxicities following I-MIBG therapy using our hospital data and questionnaires from the hospitals that these patients were initially referred from. Read More

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http://dx.doi.org/10.1007/s12149-020-01460-zDOI Listing

Ga-DOTATATE positron emission tomography/computed tomography to detect the recurrence of phosphaturic mesenhcymal tumor-induced osteomalacia.

World J Nucl Med 2020 Jan-Mar;19(1):78-81. Epub 2019 Jul 23.

Department of Radiology, Froedtert Hospital and The Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) has shown superiority over Indium-octreotide scanning for the detection of phosphaturic mesenchymal tumors (PMTs). We report a case of tumor-induced osteomalacia resulting from PMT which, although initially clinically suspected, was not localized on octreotide scintigraphy performed several years prior. Subsequent surgical excision of a presumed benign osseous lesion a few years later revealed the diagnosis on pathology. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_92_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067133PMC

Theranostic approaches in nuclear medicine: current status and future prospects.

Expert Rev Med Devices 2020 Apr 19;17(4):331-343. Epub 2020 Mar 19.

Department of Nuclear Medicine, Santa Maria Goretti Hospital, Latina, Italy.

: Theranostics is an emerging field in which diagnosis and specific targeted therapy are combined to achieve a personalized treatment approach to the patient. In nuclear medicine clinical practice, theranostics is often performed utilizing the same molecule labeled with two different radionuclides, one radionuclide for imaging and another for therapy.: The authors review the clinical applications of different radiopharmaceuticals in the field of interest, including the well-established use of radioactive iodine in differentiated thyroid cancer, radiolabeled metaiodobenzylguanidine (MIBG) in neuroblastoma and the clinical impact of peptide radionuclide receptorial therapy (PRRT) in the management of neuroendocrine tumors. Read More

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http://dx.doi.org/10.1080/17434440.2020.1741348DOI Listing

A phase IIa trial of molecular radiotherapy with 177-lutetium DOTATATE in children with primary refractory or relapsed high-risk neuroblastoma.

Eur J Nucl Med Mol Imaging 2020 Mar 11. Epub 2020 Mar 11.

Department of Oncology, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London, NW1 2PG, UK.

Purpose: The objective of this phase IIa, open-label, single-centre, single-arm, two-stage clinical trial was to evaluate the safety and activity of 177-lutetium DOTATATE (LuDO) molecular radiotherapy in neuroblastoma.

Methods: Children with relapsed or refractory metastatic high-risk neuroblastoma were treated with up to four courses of LuDO. The administered activity was 75 to 100 MBq kg per course, spaced at 8- to 12-week intervals. Read More

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http://dx.doi.org/10.1007/s00259-020-04741-xDOI Listing

Radiolabeled (R)-(-)-5-iodo-3'-O-[2-(ε-guanidinohexanoyl)-2-phenylacetyl]-2'-deoxyuridine: A new theranostic for neuroblastoma.

J Labelled Comp Radiopharm 2020 Mar 9. Epub 2020 Mar 9.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Neuroblastoma, the most common extracranial solid tumor in children, accounts for nearly 8% of childhood cancers in the United States. It is a disease with pronounced clinical and biological heterogeneities. The amplification of MYCN, whose key tumorigenic functions include the promotion of proliferation, facilitation of the cell's entry into the S phase, and prevention of cells from leaving the cell cycle, correlates with poor prognosis. Read More

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http://dx.doi.org/10.1002/jlcr.3836DOI Listing

Development and validation of a nomogram to predict the overall survival of patients with neuroblastoma.

Medicine (Baltimore) 2020 Mar;99(10):e19199

Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, China.

Neuroblastoma is the most prevalent malignancy in infants characterized by heterogeneous prognosis. It is critical to stratify the risks for patients with neuroblastoma. To stratify the risks for neuroblastoma, clinical characteristics of neuroblastoma patients were retrieved from the Therapeutically Applicable Research to Generate Effective Treatment program. Read More

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http://dx.doi.org/10.1097/MD.0000000000019199DOI Listing

RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma.

Lung Cancer 2020 Apr 22;142:123-131. Epub 2020 Feb 22.

Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Pathology & Molecular Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada. Electronic address:

Objectives: Increased expression of REarranged during Transfection (RET) kinase is reported in 10-20 % of lung adenocarcinomas (LUAD) and is associated with metastasis and reduced survival. Ezrin is a scaffold protein that promotes protein interactions with the actin cytoskeleton to regulate cell migration and is also associated with invasion and metastasis in cancers. RET isoforms interact with unique combinations of scaffold proteins to promote distinct signaling pathways. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.02.004DOI Listing

Surface Functionalization of Pegylated Gold Nanoparticles with Antioxidants Suppresses Nanoparticle-Induced Oxidative Stress and Neurotoxicity.

Chem Res Toxicol 2020 May 13;33(5):1195-1205. Epub 2020 Mar 13.

State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

Because of their biocompatibility and biosafety, pegylated Au NPs (Au@PEG), as a nanodrug-carrier, have been widely applied in different biomedical applications, including imaging and drug delivery systems. Under such conditions, the biosafety of Au@PEG has attracted tremendous attention. However, only a small number of studies focused on the neurotoxicity of Au@PEG used as drug delivery carriers not to mention reducing the neurotoxicity of Au@PEG. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.9b00368DOI Listing

Anti-stress, Glial- and Neuro-differentiation Potential of Resveratrol: Characterization by Cellular, Biochemical and Imaging Assays.

Nutrients 2020 Feb 29;12(3). Epub 2020 Feb 29.

DAILAB, DBT-AIST International Center for Translational and Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305-8565, Japan.

Environmental stress, exhaustive industrialization and the use of chemicals in our daily lives contribute to increasing incidence of cancer and other pathologies. Although the cancer treatment has revolutionized in last 2-3 decades, shortcomings such as (i) extremely high cost of treatment, (ii) poor availability of drugs, (iii) severe side effects and (iv) emergence of drug resistance have prioritized the need of developing alternate natural, economic and welfare (NEW) therapeutics reagents. Identification and characterization of such anti-stress NEW drugs that not only limit the growth of cancer cells but also reprogram them to perform their specific functions are highly desired. Read More

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http://dx.doi.org/10.3390/nu12030671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146125PMC
February 2020

Adrenocorticotropic Hormone-Secreting Esthesioneuroblastoma with Ectopic Cushing's Syndrome.

Yonsei Med J 2020 Mar;61(3):257-261

Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

Esthesioneuroblastoma as a source of ectopic Cushing's syndrome is rare, and to the best of our knowledge, only 20 cases have been reported worldwide. A 46-year-old healthy man visited a local clinic for general weakness and hyposmia, and underwent examination with serial endocrinological workup and brain imaging. Gallium-DOTA-TOC positron emission tomography scan was helpful where diagnosis of sellar MRI and inferior petrosal sinus sampling were discordant. Read More

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http://dx.doi.org/10.3349/ymj.2020.61.3.257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044685PMC

Hypoxia-Dependent Expression of TG2 Isoforms in Neuroblastoma Cells as Consequence of Different MYCN Amplification Status.

Int J Mol Sci 2020 Feb 18;21(4). Epub 2020 Feb 18.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy.

Transglutaminase 2 (TG2) is a multifunctional enzyme and two isoforms, TG2-L and TG2-S, exerting opposite effects in the regulation of cell death and survival, have been revealed in cancer tissues. Notably, in cancer cells a hypoxic environment may stimulate tumor growth, invasion and metastasis. Here we aimed to characterize the role of TG2 isoforms in neuroblastoma cell fate under hypoxic conditions. Read More

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http://dx.doi.org/10.3390/ijms21041364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072980PMC
February 2020

Ga-DOTATATE PET/CT Compared with I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors.

Asia Ocean J Nucl Med Biol 2020 ;8(1):8-17

Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of Ga-DOTATATE PET/CT and I-MIBG single photon emission computed tomography (SPECT)/CT in the initial diagnosis, staging and follow-up of patients with NCTs.

Methods: Twenty-five patients (males:females=8:17; age range=2-71 years) with clinically proven or suspicious neuroblastoma, pheochromocytoma (PCC) or paraganglioma (PGL) were enrolled in this prospective study and underwent both Ga-DOTATATE PET/CT and I-MIBG SPECT/CT. Read More

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http://dx.doi.org/10.22038/aojnmb.2019.41343.1280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994775PMC
January 2020