4,167 results match your criteria Neuroblastoma Imaging

Isolated central nervous system relapses in patients with high-risk neuroblastoma -clinical presentation and prognosis: experience of the Polish Paediatric Solid Tumours Study Group.

BMC Cancer 2022 Jun 25;22(1):701. Epub 2022 Jun 25.

Department of Paediatric Oncology and Haematology, Faculty of Medicine, Jagiellonian University, Medical College, Krakow, Poland.

Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of this study is the presentation and assessment of the incidence and clinical course of isolated CNS relapses. Retrospective analysis involved 848 NBL patients treated from 2001 to 2019 at 8 centres of the Polish Paediatric Solid Tumours Study Group (PPSTSG). Read More

View Article and Full-Text PDF

Nanospermidine in Combination with Nanofenretinide Induces Cell Death in Neuroblastoma Cell Lines.

Pharmaceutics 2022 Jun 7;14(6). Epub 2022 Jun 7.

Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.

A new strategy to cause cell death in tumors might be the increase of intracellular polyamines at concentrations above their physiological values to trigger the production of oxidation metabolites at levels exceeding cell tolerance. To test this hypothesis, we prepared nanospermidine as a carrier for spermidine penetration into the cells, able to escape the polyamine transport system that strictly regulates intracellular polyamine levels. Nanospermidine was prepared by spermidine encapsulation in nanomicelles and was characterized by size, zeta potential, loading, dimensional stability to dilution, and stability to spermidine leakage. Read More

View Article and Full-Text PDF

Influence of Molecular Structures on Fluorescence of Flavonoids and Their Detection in Mammalian Cells.

Biomedicines 2022 May 28;10(6). Epub 2022 May 28.

Laboratory of Molecular Neurophysiology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.

Flavonoids are being increasingly applied for the treatment of various diseases due to their anti-cancer, anti-oxidant, anti-inflammatory, and anti-viral properties. However, it is often challenging to detect their presence in cells and tissues through bioimaging, as most of them are not fluorescent or are too weak to visualize. Here, fluorescence possibilities of nine naturally occurring analogous flavonoids have been investigated through UV/visible spectroscopy, molecular structure examination, fluorescent images in mammalian cells and their statistical analysis employing aluminum chloride and diphenylboric acid 2-aminoethyl ester as fluorescence enhancers. Read More

View Article and Full-Text PDF

Dramatic response to targeted therapy in an aggressive olfactory neuroblastoma: illustrative case.

J Neurosurg Case Lessons 2022 Jun 13;3(24):CASE21663. Epub 2022 Jun 13.

Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma.

Background: Olfactory neuroblastomas are rare sinonasal tumors that arise from the olfactory epithelium. The authors presented a case of an olfactory neuroblastoma with extensive cranial invasion that demonstrated dramatic response to sorafenib, a tyrosine kinase inhibitor.

Observations: A 54-year-old man with history of prostate cancer and melanoma presented with left-sided proptosis and was found to have a 6. Read More

View Article and Full-Text PDF

Asphericity of tumor [ I]mIBG uptake as a prognostic factor in high-risk neuroblastoma.

Pediatr Blood Cancer 2022 Jun 21:e29849. Epub 2022 Jun 21.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Background: In recent years, many research groups have attempted to identify a subgroup of "ultra-high risk" patients within the high-risk neuroblastoma (NB) category. The aim of our study was to evaluate the prognostic significance of parameters derived from pretherapeutic I-meta-iodobenzylguanidine ([ I]mIBG) integrated single photon emission computed tomography and computed tomography in high-risk patients with NB.

Methods: The established parameters metabolic tumor volume (MTV), maximal standardized uptake value (SUV ) and the novel parameter tumor asphericity as well as clinical (age, stage) and genetic factors (1p/11q deletions and MYCN amplification) were analyzed in this single-center retrospective study of high-risk patients with newly diagnosed NB. Read More

View Article and Full-Text PDF

Anticancer Efficacy and Mechanisms of a Dual Targeting of Norepinephrine Transporter and Thyrointegrin αvβ3 Antagonist in Neuroblastoma.

J Cancer 2022 16;13(8):2594-2606. Epub 2022 May 16.

The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, New York 12144, United States.

In neuroendocrine tumors, the norepinephrine transporter (NET) is very active and has been exploited for diagnostic imaging purposes and/or therapy with localized radiotherapy. Integrin αvβ3 is generously expressed by and/or activated on cancer cells, but not by nonmalignant cells. In the present investigation, the anticancer efficacy of the dual targeting of norepinephrine transporter (NET), benzylguanidine (BG), and thyrointegrin αvβ3 receptors antagonist triazole tetraiodothyroacetic acid (TAT) conjugated via the non-cleavable linker polyethylene glycol (P, PEG400) in the treatment of human neuroblastoma was evaluated. Read More

View Article and Full-Text PDF

Metastatic cancer and endentulism: Exploring comorbidity to assist with differential diagnosis in a case from Vico nel Lazio (Fr, Italy), 13th-15th century CE.

Int J Paleopathol 2022 Jun 6;38:1-12. Epub 2022 Jun 6.

S.A.B.A.P.-LAZIO, Anthropological Service, Ministry of Culture, Via Pompeo Magno 2, 00189 Roma, Italy.

Objective: To differentially diagnose cranial lesions noted on a medieval skeleton and explore the importance of comorbidity.

Materials: A skull of an adult female with osteolytic and osteoblastic lesions, edentulism, and an ectopic tooth from an ossuary of the Church of Santa Maria in Vico del Lazio, Frosinone Italy, dating to the Middle Ages.

Methods: Macroscopic observations of the remains, CT scan, and differential diagnosis was undertaken. Read More

View Article and Full-Text PDF

Deuterium metabolic imaging reports on TERT expression and early response to therapy in cancer.

Clin Cancer Res 2022 Jun 9. Epub 2022 Jun 9.

University of California, San Francisco, San Francisco, United States.

Purpose: Telomere maintenance is a hallmark of cancer. Most tumors maintain telomere length via reactivation of telomerase reverse transcriptase (TERT) expression. Identifying clinically translatable imaging biomarkers of TERT can enable non-invasive assessment of tumor proliferation and response to therapy. Read More

View Article and Full-Text PDF

CT Combined with Multiparameter MRI in Differentiating Pathological Subtypes of Non-Small-Cell Lung Cancer before Surgery.

Contrast Media Mol Imaging 2022 17;2022:8207301. Epub 2022 May 17.

Department of CT Diagnosis, Yan'an People's Hospital, Yan'an, Shaanxi 716000, China.

Objective: To investigate the diagnostic value of computed tomography (CT) combined with multiparametric magnetic resonance imaging (mpMRI) for preoperative differentiation of non-small-cell lung cancer (NSCLC).

Methods: CT and MRI imaging data were collected from all patients with squamous lung cancer and adenocarcinoma admitted to our hospital from June 2019 to December 2020 (286 cases). ROC curves were plotted to evaluate the performance of CT, mpMRI, and CT combined with mpMRI to differentiate pathological subtypes of NSCLC. Read More

View Article and Full-Text PDF

Development of agarose-gelatin bioinks for extrusion-based bioprinting and cell encapsulation.

Biomed Mater 2022 Jun 15;17(5). Epub 2022 Jun 15.

School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

Three-dimensional bioprinting continues to advance as an attractive biofabrication technique to employ cell-laden hydrogel scaffolds in the creation of precise, user-defined constructs that can recapitulate the native tissue environment. Development and characterisation of new bioinks to expand the existing library helps to open avenues that can support a diversity of tissue engineering purposes and fulfil requirements in terms of both printability and supporting cell attachment. In this paper, we report the development and characterisation of agarose-gelatin (AG-Gel) hydrogel blends as a bioink for extrusion-based bioprinting. Read More

View Article and Full-Text PDF

Clinical parameters combined with radiomics features of PET/CT can predict recurrence in patients with high-risk pediatric neuroblastoma.

BMC Med Imaging 2022 May 28;22(1):102. Epub 2022 May 28.

Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xi Cheng District, Beijing, 100045, China.

Background: This retrospective study aimed to develop and validate a combined model based [F]FDG PET/CT radiomics and clinical parameters for predicting recurrence in high-risk pediatric neuroblastoma patients.

Methods: Eighty-four high-risk neuroblastoma patients were retrospectively enrolled and divided into training and test sets according to the ratio of 3:2. [F]FDG PET/CT images of the tumor were segmented by 3D Slicer software and the radiomics features were extracted. Read More

View Article and Full-Text PDF

A practical solution to estimate the sample size required for clinical prediction models generated from observational research on data.

Eur Radiol Exp 2022 06 1;6(1):22. Epub 2022 Jun 1.

Biomedical Imaging Research Group (GIBI230-PREBI) at La Fe Health Research Institute and the Imaging La Fe node of the Distributed Network for Biomedical Imaging (ReDIB) Unique Scientific and Technical Infrastructures (ICTS), Valencia, Spain.

Background: Estimating the required sample size is crucial when developing and validating clinical prediction models. However, there is no consensus about how to determine the sample size in such a setting. Here, the goal was to compare available methods to define a practical solution to sample size estimation for clinical predictive models, as applied to Horizon 2020 PRIMAGE as a case study. Read More

View Article and Full-Text PDF

11,12-Diacetyl-carnosol Protects SH-SY5Y Cells from Hydrogen Peroxide Damage through the Nrf2/HO-1 Pathway.

Evid Based Complement Alternat Med 2022 17;2022:4376812. Epub 2022 May 17.

College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China.

Background: Oxidative stress-induced neurotoxicity plays a key role in Alzheimer's disease (AD). 11,12-Diacetyl-carnosol (NO.20), an acetylated derivative of carnosol extracted from rosemary, displays a high antioxidative effect in vitro. Read More

View Article and Full-Text PDF

Neuroblastoma: Essential genetic pathways and current therapeutic options.

Eur J Pharmacol 2022 Jul 20;926:175030. Epub 2022 May 20.

Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan. Electronic address:

Neuroblastoma is a very diverse pediatric tumor that starts from the neural crest, and it is responsible over more than 15% of all juvenile cancer deaths. Clinical signs and symptoms are highly dependent on tumor origin and spread. Bone, lymph nodes, liver, intracranial and orbital tissues, lungs, and the central nervous system are frequently involved in metastatic neuroblastoma. Read More

View Article and Full-Text PDF

Paediatric neuroblastoma presenting as an asymptomatic abdominal mass: a report on the importance of a complete clinical examination with a view to a timely diagnosis and therapeutic guidance in paediatric oncology.

BMJ Case Rep 2022 May 19;15(5). Epub 2022 May 19.

Paediatric, Hospital Distrital da Figueira da Foz, Figueira da Foz, Portugal.

Neuroblastoma (NB) is the most common extracranial solid tumour in children after lymphoblastic leukaemias, brain tumours and lymphomas.We report a case of an NB in a previously healthy toddler. Though she had no abdominal complaints, on physical examination, she had a palpable mass identified over the right upper portion of the abdomen. Read More

View Article and Full-Text PDF

Injection of human neuroblastoma cells into neural crest streams in live zebrafish embryos.

STAR Protoc 2022 Jun 9;3(2):101380. Epub 2022 May 9.

Department of Biological Sciences, University of Illinois Chicago, Chicago, IL 60607, USA.

Cancer cell behavior is highly microenvironment dependent, but we have a limited understanding of malignant cell-microenvironment interactions . Here, we describe a protocol for xenotransplanting human neuroblastoma (NB) cells into streams of migrating neural crest stem cells in zebrafish embryos, followed by confocal time-lapse imaging and cell tracking. This high-resolution model system facilitates the quantitative spatiotemporal analysis of cancer cell-cell and cell-environment interactions. Read More

View Article and Full-Text PDF

Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review.

Am J Rhinol Allergy 2022 May 18:19458924221096913. Epub 2022 May 18.

Section of Otolaryngology - Head and Neck Surgery, 21727The University of Chicago Medical Center, Chicago, Illinois, USA.

Background: Patients with acquired, idiopathic olfactory dysfunction (OD) commonly undergo magnetic resonance imaging (MRI) evaluation to rule out intracranial pathologies. This practice is highly debated given the expense of MRI relative to the probability of detecting a treatable lesion. This, combined with the increasing use of MRI in research to investigate the mechanisms underlying OD, provided the impetus for this comprehensive review. Read More

View Article and Full-Text PDF

Olfactory Neuroblastoma: An Unusual Ocular Presentation.

Neuroophthalmology 2022 25;46(3):182-185. Epub 2021 Aug 25.

Emergency Department, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.

We report a case of 51-year-old medically healthy male who presented with gradual painless diminution of vision in both eyes for 3 months. His visual acuity was hand movement perception in the right eye, and no light perception in the left eye. The intraocular pressure, external eye examination, ocular motility and anterior segment examinations were normal. Read More

View Article and Full-Text PDF

Saccadic intrusions in pediatric non-accidental trauma.

Am J Ophthalmol Case Rep 2022 Jun 2;26:101564. Epub 2022 May 2.

The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Purpose: To report a case of saccadic intrusions in a 9-month-old under the context of non-accidental trauma.

Observations: A 9-month-old female presented with the eye finding of intermittent ocular flutter. Upon imaging for neuroblastoma, she was discovered to have bilateral supratentorial subdural hematomas with internal septations, moderate mass effect on adjacent cerebral parenchyma, pachymeningeal and tentorial enhancement, and cortical vein thrombosis. Read More

View Article and Full-Text PDF

Usefulness of 18F-FDG PET/computed tomography in differentiating between subacute and chronic aortic dissection: initial investigation.

Nucl Med Commun 2022 Jul 13;43(7):794-799. Epub 2022 May 13.

Department of Radiology, Mie University Hospital, Edobashi, Tsu.

Objectives: In the selection of thoracic endovascular repair for aortic dissection (AD), it is important to distinguish between the subacute and chronic phases, but there is no reliable way to distinguish between them in patients with unknown onset of AD. The purpose of this study was to assess the diagnostic performance of 2-[18F] fluoro-2-deoxy-d-glucose (18F-FDG)-PET/computed tomography (PET/CT) for discriminating subacute AD from chronic AD.

Methods: Thirteen patients with AD who were medically treated and followed up for 6 months were studied. Read More

View Article and Full-Text PDF

Nasoethmoidal Schwannoma as a Mimicar of Esthesioneuroblastoma: A Case Report and Literature Review.

Neurol India 2022 Mar-Apr;70(2):784-787

Department of Otorhinolaryngology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Nasoethmoidal schwannomas are rare lesions and their presentation with intracranial extension is even rarer. Here, a patient presenting with rhinorrhea, epistaxis, and proptosis of left eye was diagnosed with giant nasoethmoidal schwannoma extending to frontal lobe and orbit, which was managed with bifrontal craniotomy with endoscopic transnasal gross total excision. This being predominantly a benign lesion has good prognosis if total excision is achieved. Read More

View Article and Full-Text PDF

Conditioned medium from amniotic fluid mesenchymal stem cells could modulate Alzheimer's disease-like changes in human neuroblastoma cell line SY-SY5Y in a paracrine manner.

Tissue Cell 2022 Jun 4;76:101808. Epub 2022 May 4.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Alzheimer's disease is usually diagnosed by significant extracellular deposition of beta-amyloid and intracellular neurofibrillary tangle formation. Here, we investigated the paracrine effect of amniotic fluid-derived mesenchymal stem cells on AD changes in human SH-SY5Y cells.

Methods: SH-SY5Y cells were divided into five groups: Control, 0. Read More

View Article and Full-Text PDF

Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model.

ACS Chem Neurosci 2022 May 6;13(10):1505-1516. Epub 2022 May 6.

Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, California 94158, United States.

Lysosomes are intracellular organelles responsible for the degradation of diverse macromolecules in a cell. A highly acidic pH is required for the optimal functioning of lysosomal enzymes. Loss of lysosomal intralumenal acidity can disrupt cellular protein homeostasis and is linked to age-related diseases such as neurodegeneration. Read More

View Article and Full-Text PDF

Case Report: Esthesioneuroblastoma Involving the Optic Pathways.

Front Surg 2022 19;9:875881. Epub 2022 Apr 19.

Department of Neurosurgery, AC Camargo Cancer Center, São Paulo, Brazil.

Olfactory neuroblastoma, or esthesioneuroblastoma, is an uncommon malignant tumor originating from the neural crest that commonly occurs in the upper nasal cavity. Its ectopic origin is extremely rare, especially when located in the optical pathways. This paper reports the case of a giant ectopic esthesioneuroblastoma of the optic pathways that were surgically treated through a cranio-orbital-zygomatic (COZ) craniotomy with extensive resection, in addition to a literature review. Read More

View Article and Full-Text PDF

Thyroid function after diagnostic I-metaiodobenzylguanidine in children with neuroblastic tumors.

Ann Nucl Med 2022 Jun 2;36(6):579-585. Epub 2022 May 2.

Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands.

Background: Metaiodobenzylguanidine (MIBG) labeled with radioisotopes can be used for diagnostics I) and treatment (I) in patients with neuroblastic tumors. Thyroid dysfunction has been reported in 52% of neuroblastoma (NBL) survivors after I-MIBG, despite thyroid protection. Diagnostic I-MIBG is not considered to be hazardous for thyroid function; however, this has never been investigated. Read More

View Article and Full-Text PDF

Elevation of phospholipase C-β1 expression by amyloid-β facilitates calcium overload in neuronal cells.

Brain Res 2022 Aug 22;1788:147924. Epub 2022 Apr 22.

Cell Logistics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. Electronic address:

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. Amyloid-β (Aβ) has long been considered a key cause of neurodegeneration in the AD brain. Although the mechanisms underlying Aβ-induced neurodegeneration are not fully understood, a number of recent studies have suggested that intracellular calcium overload mediates this process. Read More

View Article and Full-Text PDF

CT-based morphologic and radiomics features for the classification of MYCN gene amplification status in pediatric neuroblastoma.

Childs Nerv Syst 2022 Apr 23. Epub 2022 Apr 23.

Department of Diagnostic & Interventional Imaging, KK Womens' and Childrens' Hospital, 100 Bukit Timah Rd, Singapore, 229899, Singapore.

Purpose: MYCN onco-gene amplification in neuroblastoma confers patients to the high-risk disease category for which prognosis is poor and more aggressive multimodal treatment is indicated. This retrospective study leverages machine learning techniques to develop a computed tomography (CT)-based model incorporating semantic and non-semantic features for non-invasive prediction of MYCN amplification status in pediatric neuroblastoma.

Methods: From 2009 to 2020, 54 pediatric patients treated for neuroblastoma at a specialized children's hospital with pre-treatment contrast-enhanced CT and MYCN status were identified (training cohort, n = 44; testing cohort, n = 10). Read More

View Article and Full-Text PDF

Osteogenesis Imperfecta/Ehlers-Danlos Overlap Syndrome and Neuroblastoma-Case Report and Review of Literature.

Genes (Basel) 2022 03 25;13(4). Epub 2022 Mar 25.

Department of Human Pathology in Adulthood and Childhood, University of Messina, Gaetano Martino University Hospital, 98125 Messina, Italy.

Osteogenesis imperfecta/Ehlers-Danlos (OI/EDS) overlap syndrome is a recently described disorder of connective tissue, characterized by mutation of (17q21.33) or (7q21.3) genes, that are involved in α-1 and α-2 chains of type 1 collagen synthesis. Read More

View Article and Full-Text PDF

Reversal of genetic brain iron accumulation by N,N'-bis(2-mercaptoethyl)isophthalamide, a lipophilic metal chelator, in mice.

Arch Toxicol 2022 Jul 21;96(7):1951-1962. Epub 2022 Apr 21.

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.

N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) is a novel lipophilic metal chelator and antioxidant used in mercury poisoning. Recent studies have suggested that NBMI may also bind to other metals such as lead and iron. Since NBMI can enter the brain, we evaluated if NBMI removes excess iron from the iron-loaded brain and ameliorates iron-induced oxidative stress. Read More

View Article and Full-Text PDF

Whole-tumour apparent diffusion coefficient (ADC) histogram analysis to identify MYCN-amplification in neuroblastomas: preliminary results.

Eur Radiol 2022 Apr 18. Epub 2022 Apr 18.

Department of Radiology, Children's Hospital of Philadelphia, Roberts Center for Pediatric Research, Office 3122, 3rd Floor, 2716 South Street, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Objectives: To determine the role of apparent diffusion coefficient (ADC) histogram analysis in the identification of MYCN-amplification status in neuroblastomas.

Methods: We retrospectively evaluated imaging records from 62 patients with neuroblastomas (median age: 15 months (interquartile range (IQR): 7-24 months); 38 females) who underwent magnetic resonance imaging at our institution before the initiation of any therapy or biopsy. Fourteen patients had MYCN-amplified (MYCNA) neuroblastoma. Read More

View Article and Full-Text PDF