3,522 results match your criteria Neuroblastoma Imaging


Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease.

J Food Drug Anal 2019 Apr 12;27(2):551-564. Epub 2019 Jan 12.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. Electronic address:

Alzheimer's disease (AD) is the most common cause of dementia in late life. It is difficult to precisely diagnose AD at early stages, making biomarker search essential for further developments. The objective of this study was to identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ). Read More

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http://dx.doi.org/10.1016/j.jfda.2018.11.009DOI Listing
April 2019
2 Reads
0.395 Impact Factor

Value of fluorine-18-fluorodeoxyglucose PET/CT in localizing the primary lesion in adrenocorticotropic hormone-dependent Cushing syndrome.

Nucl Med Commun 2019 May;40(5):539-544

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine.

Objective: This study aimed to present a proper understanding of the fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) value in localizing the primary lesion in adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome in a relatively large case cohort.

Patients And Methods: This retrospective study included 47 patients with ACTH-dependent Cushing syndrome, who underwent an F-FDG PET/CT examination in our hospital from November 2010 to January 2018. The serum cortisol, 24 h urine cortisol, serum ACTH, and high-dose dexamethasone suppression test were measured in all the patients. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000989DOI Listing
May 2019
1 Read

Role of the extent of prophylactic regional lymph node radiotherapy on survival in high-risk neuroblastoma: A report from the COG A3973 study.

Pediatr Blood Cancer 2019 Apr 9:e27736. Epub 2019 Apr 9.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts.

Purpose: Neuroblastoma is the most common extracranial solid pediatric malignancy, with poor outcomes in high-risk disease. Standard treatment approaches employ an increasing array of aggressive multimodal therapies, of which local control with surgery and radiotherapy remains a backbone; however, the benefit of broad regional nodal irradiation remains controversial. We analyzed centrally reviewed radiation therapy data from patients enrolled on COG A3973 to evaluate the impact of primary site irradiation and the extent of regional nodal coverage stratified by extent of surgical resection. Read More

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http://dx.doi.org/10.1002/pbc.27736DOI Listing
April 2019
1 Read

Adrenal masses in children: Imaging, surgical treatment and outcome.

Asian J Surg 2019 Apr 5. Epub 2019 Apr 5.

Department of Pediatric Surgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey.

Background/objective: This study aims to evaluate the current surgical approach to adrenal masses in the pediatric age group.

Methods: We retrospectively analyzed cases that underwent surgery for adrenal masses between 2007 and 2017. Patients were assessed regarding age, sex, primary diagnosis, image defined risk factors (IDRF), surgical treatment method, complications, duration of hospital stay, and follow-up. Read More

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http://dx.doi.org/10.1016/j.asjsur.2019.03.012DOI Listing
April 2019
1 Read

Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells.

Life Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Biology, National Changhua University of Education, 1 Jin-De Rd., Changhua 50007, Taiwan. Electronic address:

Aim: Fluoxetine (FXT), a selective serotonin reuptake inhibitor (SSRI), is one of the most common psychiatric medications clinically prescribed; while over-produced serotonin may suppress neurite development. The role of major iridoids like geniposide (GPS) and genipin (GNP) from Gardenia jasminoides Ellis fruit (family Rubiaceae) in ameliorating the anti-neurite outgrowth effect of FXT is poorly understood. In this study, the effects of these iridoids on FXT-suppressed neurite outgrowth in Neuro2a neuroblastoma cells were investigated. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.003DOI Listing
April 2019
1 Read

Preclinical pharmacokinetics and dosimetry studies of [I/I]-CLR1404 for treatment of pediatric solid tumors in murine xenograft models.

J Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

University of Wisconsin-Madison, United States.

Pediatric cancer is the second leading cause of death for children between the ages of 5-14. For children diagnosed with metastatic or recurrent solid tumors, where the utility of external-beam radiotherapy is limited, the prognosis is particularly poor. The availability of tumor-targeting radiopharmaceuticals for molecular radiotherapy (MRT) has demonstrated improved outcomes in these patient populations, but options are nonexistent or limited for most pediatric solid tumors. Read More

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http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.118.225
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http://dx.doi.org/10.2967/jnumed.118.225409DOI Listing
March 2019
6 Reads

SFCE METRO-01 four-drug metronomic regimen phase II trial for pediatric extracranial tumor.

Pediatr Blood Cancer 2019 Mar 28:e27693. Epub 2019 Mar 28.

Department of Pediatric Oncology, La Timone Children's Hospital, Marseille, France.

Objective: To investigate the antitumor activity of a four-drug metronomic chemotherapy (MC) regimen in relapsed/progressing pediatric extracranial solid tumors (EST). The primary objective was clinical benefit (complete response /partial response/stable disease [SD]) after two cycles of therapy (four months).

Methods: Patients aged ≥4 to 25 years with progressing EST and adequate organ function were eligible. Read More

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http://dx.doi.org/10.1002/pbc.27693DOI Listing

Polymer microchamber arrays for geometry-controlled drug release: a functional study in human cells of neuronal phenotype.

Biomater Sci 2019 Mar 27. Epub 2019 Mar 27.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

Polyelectrolyte multilayer (PEM) microchambers can provide a versatile cargo delivery system enabling rapid, site-specific drug release on demand. However, experimental evidence for their potential benefits in live human cells is scarce. Equally, practical applications often require substance delivery that is geometrically constrained and highly localized. Read More

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http://dx.doi.org/10.1039/c8bm01499jDOI Listing
March 2019
2 Reads

Posterior retroperitoneoscopic adrenalectomy for pediatric adrenal tumors.

J Pediatr Surg 2019 Feb 28. Epub 2019 Feb 28.

Department of Paediatric Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899. Electronic address:

Background/aims: Posterior retroperitoneoscoic adrenalectomy has been reported as an option for adrenal tumor resection but is not commonly performed in children owing to the extreme semikneeling position advocated to flatten the lumbar lordosis in order to achieve adequate retroperitoneal space. As children have smaller lordosis angles, flattening of the lordosis and creation of optimal retroperitoneal space may be achieved with less hip flexion. We used pediatric lumbar lordosis measurements to develop a modified prone jackknife position and report our experiences with this setup for posterior retroperitoneoscopic adrenalectomy for adrenal tumors. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.068DOI Listing
February 2019
2 Reads

MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Anti-angiogenic Treatment.

Cancer Res 2019 Mar 15. Epub 2019 Mar 15.

Division of Radiotherapy and Imaging, The Institute of Cancer Research, London

Childhood neuroblastoma is a hypervascular tumor of neural origin for which antiangiogenic drugs are currently being evaluated; however, predictive biomarkers of treatment response, crucial for successful delivery of precision therapeutics, are lacking. We describe a MRI-pathological cross-correlative approach using intrinsic susceptibility (IS-) and susceptibility contrast (SC-) MRI to non-invasively map the vascular phenotype in neuroblastoma Th-MYCN transgenic mice treated with the vascular endothelial growth factor receptor inhibitor cediranib. We showed that the transverse MRI relaxation rate R2* (s-1) and fractional blood volume fBV (%) were sensitive imaging biomarkers of hemorrhage and vascular density, respectively, and were also predictive biomarkers of response to cediranib. Read More

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-3412DOI Listing
March 2019
4 Reads

Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines.

PLoS One 2019 14;14(3):e0213776. Epub 2019 Mar 14.

Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States of America.

High-risk neuroblastoma (NB) is lethal childhood cancer. Published data including ours have reported the anti-proliferative effect of Xanthohumol (XN), a prenylated chalcone, in various cancer types suggesting that XN could be a useful small molecule compound against cancer. The TNF-Related Apoptosis-Inducing Ligand (TRAIL) is an endogenous ligand that is expressed in various immune cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417737PMC
March 2019
2 Reads

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups.

Inorg Chem 2019 Apr 14;58(7):4540-4552. Epub 2019 Mar 14.

The Centre for Molecular Imaging and Translational Research Laboratory , The Peter MacCallum Cancer Centre , Melbourne , Victoria 3000 , Australia.

The synthesis of new bis(thiosemicarbazonato)copper(II) complexes featuring polyamine substituents via selective transamination reactions is presented. Polyamines of different lengths, with different ionizable substituent groups, were used to modify and adjust the hydrophilic/lipophilic balance of the copper complexes. The new analogues were radiolabeled with copper-64 and their lipophilicities estimated using distribution coefficients. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00117DOI Listing
April 2019
1 Read

Esthesioneuroblastoma: A Comprehensive review of Diagnosis, Management and current Treatment options.

World Neurosurg 2019 Mar 9. Epub 2019 Mar 9.

Department of Neurosurgery, Desert Regional Medical Center, Palm Springs, CA, USA.

Introduction: Many controversies exist in the diagnosis and management of this aggressively malignant condition, mainly due to limited literature and lack of randomized control trails resulting in non-standardized treatment methods. The authors performed comprehensive review of the available literature for current management approach and treatment options for ENB.

Methods: An extensive review of the published literature was conducted in PubMed, OVID Medline and EMBASE Journals for studies on Esthesioneuroblastoma (ENB). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.014DOI Listing
March 2019
3 Reads

Metabolic Evaluation of MYCN-Amplified Neuroblastoma by 4-[F]FGln PET Imaging.

Mol Imaging Biol 2019 Mar 8. Epub 2019 Mar 8.

Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Purpose: This study aims to explore whether 4-(2S,4R)-[F]fluoroglutamine (4-[F]FGln) positron emission tomography (PET) imaging is helpful in identifying and monitoring MYCN-amplified neuroblastoma by enhanced glutamine metabolism.

Procedures: Cell uptake studies and dynamic small-animal PET studies of 4-[F]FGln and 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG) were conducted in human MYCN-amplified (IMR-32 and SK-N-BE (2) cells) and non-MYCN-amplified (SH-SY5Y cell) neuroblastoma cells and animal models. Subsequently, short hairpin RNA (shRNA) knockdown of alanine-serine-cysteine transporter 2 (ASCT2/SLC1A5) in IMR-32 cells and xenografts were investigated in vitro and in vivo. Read More

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http://dx.doi.org/10.1007/s11307-019-01330-9DOI Listing
March 2019
1 Read

Dosimetry-based high-activity therapy with I-metaiodobenzylguanidine (I-mIBG) and topotecan for the treatment of high-risk refractory neuroblastoma.

Eur J Nucl Med Mol Imaging 2019 Mar 5. Epub 2019 Mar 5.

Department of Pediatric Oncology and Hematology, Cruces University Hospital, Plaza de Cruces s/n, 48903, Baracaldo, Vizcaya, Spain.

Purpose: Patients with high-risk neuroblastoma have an increased risk of recurrence and relapse of disease and a very poor prognosis. I-metaiodobenzylguanidine (I-mIBG) in combination with topotecan as a radiosensitizer can be an effective and relatively well-tolerated agent for the treatment of refractory neuroblastoma. The aim of this retrospective study was to evaluate response and outcome of combined therapy with I-mIBG and topotecan. Read More

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http://dx.doi.org/10.1007/s00259-019-04291-xDOI Listing
March 2019
2 Reads

Multidisciplinary surgical strategy for dumbbell neuroblastoma: A single-center experience of 32 cases.

Pediatr Blood Cancer 2019 Mar 4:e27670. Epub 2019 Mar 4.

Department of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

Introduction: Prognosis of dumbbell neuroblastoma (NBL) is mainly determined by the sequelae induced by the tumor itself and the neurosurgical approach. However, after primary chemotherapy, surgical management of the residual tumor, especially the spinal canal component, remains controversial.

Methods: We conducted a single-center retrospective cohort study over the last 15 years (2002-2017) including patients treated for NBL with spinal canal extension focusing on timing and type of surgery, complications, and functional and oncological follow-up. Read More

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http://doi.wiley.com/10.1002/pbc.27670
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http://dx.doi.org/10.1002/pbc.27670DOI Listing
March 2019
5 Reads

Likelihood of Diagnosing Neuroblastoma in Isolated Horner Syndrome.

J Neuroophthalmol 2019 Feb 18. Epub 2019 Feb 18.

Department of Ophthalmology (NG-C), Bnai Zion Medical Center, Haifa, Israel; Krieger Eye Research Laboratory (NG-C), Felsenstein Medical Research Center, Beilinson Hospital, Petach Tikva, Israel; The Ruth and Bruce Rappaport Faculty of Medicine (NG-C), Technion, Haifa, Israel; Sackler Faculty of Medicine (ABS, HT, SA), Tel Aviv University, Tel Aviv, Israel; Department of Radiology (JL), Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel; Department of Pediatric Oncology (HT, SA), Schneider Children's Medical Center of Israel, Petach Tikva; Israel.

Background: The need for an extensive evaluation for neuroblastoma in children with Horner syndrome is controversial.

Methods: A retrospective study design was used. The cohort included 47 children with anisocoria who were diagnosed with Horner syndrome and 135 children with neuroblastoma evaluated at a pediatric medical center between 2007 and 2015. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000764DOI Listing
February 2019
1 Read
1.807 Impact Factor

Synthesis and evaluation of Tc-analogues of [I]mIBG prepared via [Tc][Tc(CO)(HO)] synthon for targeting norepinephrine transporter.

Nucl Med Biol 2019 Jan - Feb;68-69:49-57. Epub 2019 Jan 18.

Homi Bhabha National Institute (HBNI), Anushaktinagar, Mumbai 400094, India; Radiopharmaceutical Division, Bhabha Atomic Research Centre (BARC), Trombay, Mumbai 400085, India.

Introduction: meta-[I]Iodobenzylguanidine (mIBG) is a clinical agent used for imaging neuroendocrine tumors, where uptake in tumor is via active transport mechanism through norepinephrine transporters (NET). Our group in past have evaluated a Tc-analogue of the above tracer, based on Tc-4 + 1 labeling approach, which exhibited significant affinity for NET but suffered from reduced specific uptake in comparison to reference standard no-carrier-added (n.c. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2019.01.001DOI Listing
January 2019
2.412 Impact Factor

Technical Note: Simplified and practical pretherapy tumor dosimetry - A feasibility study for I-MIBG therapy of neuroblastoma using I-MIBG PET/CT.

Med Phys 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.

Purpose: Radiation dose calculated on tumors for radiopharmaceutical therapy varies significantly from tumor to tumor and from patient to patient. Accurate estimation of radiation dose requires multiple time point measurements using radionuclide imaging modalities such as SPECT or PET. In this report, we show our technical development of reducing the number of scans needed for reasonable estimation of tumor and normal organ dose in our pretherapy imaging and dosimetry platform of I-metaiodobenzylguanidine (MIBG) positron emission tomography/computed tomography (PET/CT) for I-MIBG therapy of neuroblastoma. Read More

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http://dx.doi.org/10.1002/mp.13446DOI Listing
February 2019

Elucidating the inhibitory potential of Vitamin A against fibrillation and amyloid associated cytotoxicity.

Int J Biol Macromol 2019 May 7;129:333-338. Epub 2019 Feb 7.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. Electronic address:

Protein aggregation and amyloid fibrillation are associated with many serious human pathophysiologies like Alzheimer's, Parkinson's diseases, type II diabetes etc. A powerful strategy for controlling and understanding amyloid protein aggregation is the modulation of protein self-assembly. In this study, anti-fibrillation activity of vitamin A (VA) and its effect on the kinetics of amyloid formation of Aβ-42 peptide was investigated by employing various spectroscopic, imaging and computational approaches. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.134DOI Listing
May 2019
2 Reads
2.858 Impact Factor

Esthesioneuroblastoma: An Unusual Presentation with Intractable Headache.

Cureus 2018 Nov 28;10(11):e3653. Epub 2018 Nov 28.

Radiology, Osceola Regional Medical Center, Kissimmee, USA.

Esthesioneuroblastoma, also known as olfactory neuroblastoma, is a malignant tumor of the upper nasal cavity. This report illustrates the case of a 63-year-old woman who presented with intractable headaches. Subsequent radiologic evaluation and correlation with histopathologic analysis confirmed esthesioneuroblastoma. Read More

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http://dx.doi.org/10.7759/cureus.3653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351115PMC
November 2018
3 Reads

SCAPER localizes to primary cilia and its mutation affects cilia length, causing Bardet-Biedl syndrome.

Eur J Hum Genet 2019 Feb 5. Epub 2019 Feb 5.

The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Beer Sheva, Israel.

Studies of ciliopathies have served in elucidating much of our knowledge of structure and function of primary cilia. We report humans with Bardet-Biedl syndrome who display intellectual disability, retinitis pigmentosa, obesity, short stature and brachydactyly, stemming from a homozyogous truncation mutation in SCAPER, a gene previously associated with mitotic progression. Our findings, based on linkage analysis and exome sequencing studies of two remotely related large consanguineous families, are in line with recent reports of SCAPER variants associated with intellectual disability and retinitis pigmentosa. Read More

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http://www.nature.com/articles/s41431-019-0347-z
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http://dx.doi.org/10.1038/s41431-019-0347-zDOI Listing
February 2019
13 Reads

Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting α-glucosidase on cell membranes.

Bioorg Med Chem 2019 Mar 28;27(5):859-864. Epub 2019 Jan 28.

Department of Bioscience and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.

Molecules designed for cell-specific imaging were studied, taking advantage of an enzyme-inhibitor interaction. 1-Deoxynojirimycin (DNJ) can be actively captured by cells which express the surface membrane protein α-glucosidase. New probes composed of DNJ for recognition linked to a fluorophore signal portion were prepared (DNJ-CF1, DNJ-Dans 2 and DNJ-DEAC 3). Read More

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http://dx.doi.org/10.1016/j.bmc.2019.01.032DOI Listing
March 2019
2 Reads

Overcoming Biological Barriers in Neuroblastoma Therapy: The Vascular Targeting Approach with Liposomal Drug Nanocarriers.

Small 2019 Mar 1;15(10):e1804591. Epub 2019 Feb 1.

Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.

Neuroblastoma is a rare pediatric cancer characterized by a wide clinical behavior and adverse outcome despite aggressive therapies. New approaches based on targeted drug delivery may improve efficacy and decrease toxicity of cancer therapy. Furthermore, nanotechnology offers additional potential developments for cancer imaging, diagnosis, and treatment. Read More

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http://dx.doi.org/10.1002/smll.201804591DOI Listing
March 2019
1 Read

Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study.

Eur Radiol Exp 2019 Jan 30;3(1). Epub 2019 Jan 30.

Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Schweitzer-Allee 23, 89081, Ulm, Germany.

Background: Quantitative diffusion-weighted imaging (DWI) probes into tissue microstructure in solid tumours. In this retrospective ethically approved study, we investigated DWI as a potential non-invasive predictor of tumour dignity and prognosis in paediatric patients with neuroblastic tumours.

Methods: Nineteen consecutive patients with neuroblastoma (NB, n = 15), ganglioneuroblastoma (GNB, n = 1) and ganglioneuroma (GN, n = 3) underwent 3-T magnetic resonance imaging at first diagnosis and after 3-month follow-up, following a protocol including DWI (b = 50 and 800 s/mm) in addition to standard sequences. Read More

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http://dx.doi.org/10.1186/s41747-019-0087-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353978PMC
January 2019
2 Reads

Neuroblastoma-targeting triangular gadolinium oxide nanoplates for precise excision of cancer.

Acta Biomater 2019 Mar 19;87:223-234. Epub 2019 Jan 19.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Beijing Key Laboratory Molecular Imaging, Beijing 100190, China; The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100080, China. Electronic address:

Neuroblastoma accounts for 8-10% of malignancies in infants and children. It is urgent to develop an appropriate theranostic agent for effective diagnosis and therapy of neuroblastoma. Herein, we constructed RVG peptide and IRDye800-conjugated bovine serum albumin-coated triangular gadolinium oxide nanoplates (RVG&IRDye800-GdO TNs) as a targeting MRI agent for the diagnosis of neuroblastoma preoperation and a fluorescence imaging agent for the guidance of the precise excision of the neuroblastoma in surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193006
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http://dx.doi.org/10.1016/j.actbio.2019.01.042DOI Listing
March 2019
4 Reads

Statistical Framework in Support of a Revised Children's Oncology Group Neuroblastoma Risk Classification System.

JCO Clin Cancer Inform 2018 12;2:1-15

Arlene Naranjo, University of Florida, Gainesville, FL; Meredith S. Irwin, Hospital for Sick Children, Toronto, ON, Canada; Michael D. Hogarty, University of Pennsylvania, Philadelphia, PA; Susan L. Cohn, The University of Chicago, Chicago, IL; Julie R. Park, University of Washington, Seattle, WA; and Wendy B. London, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA.

Purpose: The International Neuroblastoma Risk Group (INRG) Staging System (INRGSS) was developed through international consensus to provide a presurgical staging system that uses clinical and imaging data at diagnosis. A revised Children's Oncology Group (COG) neuroblastoma (NB) risk classification system is needed to incorporate the INRGSS and within the context of modern therapy. Herein, we provide statistical support for the clinical validity of a revised COG risk classification system. Read More

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http://dx.doi.org/10.1200/CCI.17.00140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421832PMC
December 2018
8 Reads

A novel tryptamine-appended rhodamine-based chemosensor for selective detection of Hg present in aqueous medium and its biological applications.

Anal Bioanal Chem 2019 Feb 9;411(6):1143-1157. Epub 2019 Jan 9.

Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata, 700 009, India.

A novel rhodamine-tryptamine conjugate-based fluorescent and chromogenic chemosensor (RTS) for detection of Hg present in water was reported. After gradual addition of Hg in aqueous methanol solution of RTS, a strong orange fluorescence and deep-pink coloration were observed. The probe showed high selectivity towards Hg compared to other competitive metal ions. Read More

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http://dx.doi.org/10.1007/s00216-018-1546-0DOI Listing
February 2019
2 Reads
3.436 Impact Factor

Calreticulin regulates MYCN expression to control neuronal differentiation and stemness of neuroblastoma.

J Mol Med (Berl) 2019 Mar 5;97(3):325-339. Epub 2019 Jan 5.

Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan.

Oncogenic N-MYC (MYCN) is widely used as a biomarker in clinics for neuroblastoma (NB) patients; nevertheless, mechanism that underlines MYCN regulation remains elusive. In the present study, we identified calreticulin (CRT) as a novel MYCN suppressor that downregulated MYCN promoter activity and protein expression to modulate neuronal differentiation and stemness. Our data showed that CRT-mediated MYCN suppression led to increased neurite length and commensurate elevation in differentiation marker GAP-43. Read More

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http://dx.doi.org/10.1007/s00109-018-1730-xDOI Listing
March 2019
1 Read

High Oct4 expression: implications in the pathogenesis of neuroblastic tumours.

BMC Cancer 2019 Jan 3;19(1). Epub 2019 Jan 3.

Pathology Department, Medical School, University of Valencia-INCLIVA, Av. Blasco Ibáñez, 15, 46010, Valencia, Spain.

Background: Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for tumour progression, chemotherapy resistance and recurrence in NBTs. Oct4 is a transcription factor which plays a key role in mammal embryonic development and stem cell fate regulation. Read More

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http://dx.doi.org/10.1186/s12885-018-5219-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318846PMC
January 2019

Neuroblastoma of the Bone and Bone Marrow Without an Apparent Primary Site: Report of 4 Cases With Long-term Follow-up.

Pediatr Dev Pathol 2019 Jan 2:1093526618822597. Epub 2019 Jan 2.

1 Division of Hematology-Oncology, Department of Pediatrics, Texas Children's Cancer & Hematology Centers, Baylor College of Medicine, Houston, Texas.

Children with neuroblastoma rarely present with metastatic disease without identifiable primary tumors. We describe the clinical and histopathologic characteristics of 4 patients aged 1, 7, 7, and 11 years with neuroblastoma involving bone or bone marrow without an apparent primary site. One patient presented with a periorbital bone lesion, 1 presented with a distal femoral lesion, and 2 presented with diffuse bone marrow involvement. Read More

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http://journals.sagepub.com/doi/10.1177/1093526618822597
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http://dx.doi.org/10.1177/1093526618822597DOI Listing
January 2019
3 Reads

Recurrent bloody stools associated with visceral infantile haemangioma in a preterm twin girl.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Neonatology, University of Washington, Seattle, Washington, USA.

A premature twin infant girl was transferred to a level IV neonatal intensive care unit for recurrent bloody stools, anaemia and discomfort with feeds; without radiographic evidence of necrotising enterocolitis. Additional imaging after transfer revealed a large retroperitoneal mass in the region of the pancreas compressing the inferior vena cava and abdominal aorta, raising suspicion for neuroblastoma. Abdominal exploration and biopsy unexpectedly revealed that the lesion was an infantile capillary haemangioma involving the small bowel, omentum, mesentery and pancreas. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226564
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http://dx.doi.org/10.1136/bcr-2018-226564DOI Listing
December 2018
11 Reads

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.

Clin Cancer Res 2019 Apr 18;25(7):2278-2289. Epub 2018 Dec 18.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana.

Purpose: Checkpoint kinase 1 (CHK1) inhibitors potentiate the DNA-damaging effects of cytotoxic therapies and/or promote elevated levels of replication stress, leading to tumor cell death. Prexasertib (LY2606368) is a CHK1 small-molecule inhibitor under clinical evaluation in multiple adult and pediatric cancers. In this study, prexasertib was tested in a large panel of preclinical models of pediatric solid malignancies alone or in combination with chemotherapy. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445779PMC
April 2019
10 Reads

Surgical removal of adult recurrent neuroblastoma located in the posterior mediastinum and retroperitoneum: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13642

Department of Hepatobiliary Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.

Rationale: Adult recurrent neuroblastoma is extremely rare, especially in the posterior mediastinum and retroperitoneal cavity. The surgical treatment of this special part of the tumor is also a clinical difficulty.

Patient Concerns: This study reports a case of a 24-year-old man with a history of treated posterior mediastinal neuroblastoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320002PMC
December 2018
2 Reads

[Cu]CuCl PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis.

Theranostics 2018 9;8(20):5645-5659. Epub 2018 Nov 9.

Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, NSW, Australia 2031.

Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, copper homeostasis is considered as an emerging target for anticancer drug design. Monitoring copper levels is therefore of paramount importance when assessing the efficacy of copper-targeting drugs. Herein, we investigated the activity of the copper-targeting compound Dextran-Catechin by developing a [Cu]CuCl PET imaging protocol to monitor its effect on copper homeostasis in tumors. Read More

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http://www.thno.org/v08p5645.htm
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http://dx.doi.org/10.7150/thno.29840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276294PMC
November 2018
14 Reads

Molecular Scaffolds as Double-Targeting Agents For the Diagnosis and Treatment of Neuroblastoma.

Angew Chem Int Ed Engl 2019 Mar 9;58(10):3067-3072. Epub 2019 Jan 9.

Dpto. Química en Ciencias Farmacéuticas., Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n., Spain.

The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as one of the most important challenges in the nanomedicine field. Meta-iodobenzilguanidine (MIBG) is widely used for the diagnosis of neuroblastoma (NB) due to its strong affinity for the norepinephrine transporter (NET), usually overexpressed on the membrane of malignant cells. Herein, a family of novel Y-shaped scaffolds has been synthesized, which have structural analogues of MIBG covalently attached at each end of the Y-structure. Read More

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http://dx.doi.org/10.1002/anie.201811691DOI Listing
March 2019
3 Reads

Treatment-related Focal Nodular Hyperplasia Mimicking Liver Metastases.

J Pediatr Hematol Oncol 2019 Mar;41(2):138-139

Departments of Radiology.

A 7-year-old patient with a stage 4 neuroblastoma underwent chemotherapy, surgery, myeloablative therapy, external beam radiotherapy, and Isoretinoin treatment. A posttreatment magnetic resonance examination performed administering gadoteric acid as contrast agent showed 2 new hypervascular hepatic lesions, suspicious for metastases. A second magnetic resonance imaging performed using a liver-specific contrast medium (gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid) demonstrated that these lesions were consistent with treatment-related focal nodular hyperplasia. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384128PMC
March 2019
3 Reads

Different Efflux Transporter Affinity and Metabolism of Tc-2-Methoxyisobutylisonitrile and Tc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer.

Pharm Res 2018 Nov 29;36(1):18. Epub 2018 Nov 29.

School of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Background: Little is known about the affinity and stability of Tc-labeled 2-methoxyisobutylisonitrile (Tc-MIBI) and tetrofosmin (Tc-TF) for imaging of multiple drug resistance transporters in cancer. We examined the affinity of Tc-labeled compounds for these transporters and their stability.

Methods: Tc-MIBI and Tc-TF were incubated in vesicles expressing P-glycoprotein (MDR1), multidrug resistance-associated protein (MRP)1-4, or breast cancer resistance protein with and without verapamil (MDR1 inhibitor) or MK-571 (MRP inhibitor). Read More

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http://dx.doi.org/10.1007/s11095-018-2548-5DOI Listing
November 2018
4 Reads
3.420 Impact Factor

Implications of Image-Defined Risk Factors and Primary-Site Response on Local Control and Radiation Treatment Delivery in the Management of High-Risk Neuroblastoma: Is There a Role for De-escalation of Adjuvant Primary-Site Radiation Therapy?

Int J Radiat Oncol Biol Phys 2019 Mar 26;103(4):869-877. Epub 2018 Nov 26.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.

Purpose: The predictive value of Image-Defined Risk Factors (IDRFs) developed by the International Neuroblastoma Risk Group Task Force as it relates to primary-site management is undefined and may aid patient selection for de-escalation of adjuvant radiation therapy to the primary site in high-risk neuroblastoma.

Methods And Materials: Patients (N = 76) with high-risk neuroblastoma treated on prospective trials at our institution from 1997 to 2014 were eligible for inclusion. IDRFs were defined based on pretherapy imaging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183402
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http://dx.doi.org/10.1016/j.ijrobp.2018.11.041DOI Listing
March 2019
14 Reads

Assessment of the dicentric chromosome assay as a biodosimetry tool for more personalized medicine in a case of a high risk neuroblastoma I-mIBG treatment.

Int J Radiat Biol 2019 Mar 11;95(3):314-320. Epub 2019 Jan 11.

a Radiation Protection Service , Hospital Universitario y Politécnico La Fe , Valencia , Spain.

Purpose: The aims of this study were to estimate the whole - body absorbed - dose with the Dicentric Chromosome Assay (DCA) (biodosimetry) for I - metaiodobenzylguanidine (I - mIBG) therapy for high - risk neuroblastoma, and to obtain an initial correlation with the physical dosimetry calculated as described by the Medical Internal Radiation Dosimetry formalism (MIRD). Together both objectives will aid the optimization of personalized targeted radionuclide therapies.

Material And Methods: A 12 year-old child with relapsed high-risk neuroblastoma was treated with I-mIBG: a first administration with activity <444 MBq/kg was used as a tracer in order to calculate the activity needed in a second administration to achieve a whole body prescribed dose of ∼4 Gy. Read More

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http://dx.doi.org/10.1080/09553002.2019.1549755DOI Listing
March 2019
2 Reads

Lymph node imaging of pediatric renal and suprarenal malignancies.

Transl Androl Urol 2018 Oct;7(5):774-782

Department of Urology, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Pediatric renal and suprarenal cancers are relatively rare malignancies, but are not without significant consequence to both the patient and caretakers. These tumors are often found incidentally and present as large abdominal masses. Standard of care management involves surgical excision of the mass, but contemporary treatment guidelines advocate for use of neoadjuvant or adjuvant chemotherapy for advanced stage disease, such as those cases with lymph node involvement (LNI). Read More

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http://dx.doi.org/10.21037/tau.2018.07.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212619PMC
October 2018
16 Reads

Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma.

Theranostics 2018 6;8(18):5106-5125. Epub 2018 Oct 6.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

In recent reports, we have shown that optimized pretargeted radioimmunotherapy (PRIT) based on molecularly engineered antibody conjugates and Lu-DOTA chelate (DOTA-PRIT) can be used to cure mice bearing human solid tumor xenografts using antitumor antibodies to minimally internalizing membrane antigens, GPA33 (colon) and GD2 (neuroblastoma). However, many solid tumor membrane antigens are internalized after antibody binding and it is generally believed that internalizing tumor membrane antigens are not suitable targets for PRIT. In this study, we tested the hypothesis that DOTA-PRIT can be performed successfully to target HER2, an internalizing membrane antigen widely expressed in breast, ovarian, and gastroesophageal junction cancers. Read More

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http://www.thno.org/v08p5106.htm
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http://dx.doi.org/10.7150/thno.26585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217068PMC
October 2018
18 Reads

Magnetic Resonance Imaging for Characterization of a Chick Embryo Model of Cancer Cell Metastases.

Mol Imaging 2018 Jan-Dec;17:1536012118809585

1 Department of Biochemistry, University of Liverpool, Liverpool, United Kingdom.

Metastasis is the most common cause of death for patients with cancer. To fully understand the steps involved in metastatic dissemination, in vivo models are required, of which murine ones are the most common. Therefore, preclinical imaging methods such as magnetic resonance imaging (MRI) have mainly been developed for small mammals and their potential to monitor cancer growth and metastasis in nonmammalian models is not fully harnessed. Read More

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http://dx.doi.org/10.1177/1536012118809585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236852PMC
February 2019
10 Reads

Ectopic adrenocorticotropic hormone syndrome associated with olfactory neuroblastoma: acquirement of adrenocorticotropic hormone expression during disease course as shown by serial immunohistochemistry examinations.

J Int Med Res 2018 Nov;46(11):4760-4768

1 Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Hyogo, Japan.

Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a condition of endogenous hypercortisolism sustained by an extrapituitary ACTH-secreting tumor. Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of the sinonasal tract and is derived from the olfactory epithelium. Because the paranasal sinus is not a common site of EAS, the development of ONB in patients with EAS is rare. Read More

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http://journals.sagepub.com/doi/10.1177/0300060517754026
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http://dx.doi.org/10.1177/0300060517754026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259372PMC
November 2018
15 Reads

Ocular flutter as presenting manifestation of pediatric MOG antibody-associated demyelination: A case report.

Mult Scler 2019 Jan 31;25(1):122-125. Epub 2018 Oct 31.

Neurology Department, Penteli Children's Hospital, Attica, Greece.

A 13-year-old girl presented with a 5-day history of oscillopsia. On examination, ocular flutter and mild cerebellar signs were found. Brain magnetic resonance imaging (MRI) revealed four periventricular and subcortical non-enhancing lesions. Read More

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http://dx.doi.org/10.1177/1352458518771872DOI Listing
January 2019
4 Reads

Three-Dimensional Printed Model and Virtual Reconstruction: An Extra Tool for Pediatric Solid Tumors Surgery.

European J Pediatr Surg Rep 2018 Jan 18;6(1):e70-e76. Epub 2018 Oct 18.

Department of Pediatric Surgery, Clinical University Hospital Virgen de la Arrixaca, Murcia, Spain.

 Three-dimensional (3D) technology is increasingly applied for planning challenging surgical interventions. We report our experience using 3D printing and virtual reconstruction for surgical planning of complex tumor resections in children.  Data were obtained from preoperative magnetic resonance. Read More

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http://dx.doi.org/10.1055/s-0038-1672165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202581PMC
January 2018
2 Reads

Value of SPECT/CT in Diagnostic I-131 MIBG Scintigraphy in Patients with Neuroblastoma.

Nucl Med Mol Imaging 2018 Oct 16;52(5):350-358. Epub 2018 Jul 16.

Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, 123 Mittraparp highway, Muang, Khon Kaen, 40002 Thailand.

Purpose: Diagnostic I-131 MIBG scintigraphy is an important imaging modality for evaluation of patients with neuroblastoma (NB) especially in centers where I-123 MIBG is not available. Single photon emission computed tomography/computed tomography (SPECT/CT) could potentially improve lesion detection over planar scintigraphy, but studies regarding its usefulness as an add-on to diagnostic I-131 MIBG scintigraphy are limited. This study aimed to determine the usefulness and factors related to usefulness of SPECT/CT in diagnostic I-131 MIBG scintigraphy in NB patients. Read More

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http://link.springer.com/10.1007/s13139-018-0532-y
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http://dx.doi.org/10.1007/s13139-018-0532-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177351PMC
October 2018
12 Reads

Laparoscopy as a Primary Investigatory Tool in Pediatric Abdominal Masses.

Gulf J Oncolog 2018 Sep;1(28):52-55

Division of Pediatric Surgery; Dept. of Surgery, College of Medicine, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.

Background: Management of abdominal masses still pose a major challenge for pediatrician and surgeons with many controversy as regards the best investigatory tools.

Aim Of The Work: This study was designated to evaluate the role of diagnostic laparoscopy in investigating equivocal pediatric masses that had undergone other imaging modalities.

Patients And Methods: A combined prospective and retrospective multicenter study over a period of 12 years from January 2005 to December 2016 was undertaken. Read More

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September 2018
18 Reads

Prevalence and Clinical Correlations of Somatostatin Receptor-2 (SSTR2) Expression in Neuroblastoma.

J Pediatr Hematol Oncol 2019 Apr;41(3):222-227

Departments of Pediatrics, Division of Hematology/Oncology.

Alternative radiolabeled, targeted agents are being investigated for children with relapsed neuroblastoma (NB) who do not respond to I-metaiodobenzylguanidine (MIBG) therapy. (DOTA-Tyr)-octreotate targets somatostatin receptors (SSTRs), particularly SSTR2, which are expressed on NB cells. We investigated SSTR2 expression in NB tumors (36 high-risk [HR]; 33 non-HR patients) and correlated SSTR2 levels with clinical features, norepinephrine transporter (NET) expression, and MIBG avidity. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001326DOI Listing
April 2019
1 Read

The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death.

Br J Cancer 2018 Nov 15;119(10):1278-1287. Epub 2018 Oct 15.

Department of Surgery and Cancer, Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

Background: Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A.

Methods: Autophagy substrates (light chain-3 (LC-3) and p62 proteins) and endoplasmic reticulum (ER) stress phenotype were determined. Read More

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http://dx.doi.org/10.1038/s41416-018-0232-5DOI Listing
November 2018
2 Reads