3,495 results match your criteria Neuroblastoma Imaging


Technical Note: Simplified and practical pretherapy tumor dosimetry - A feasibility study for I-MIBG therapy of neuroblastoma using I-MIBG PET/CT.

Med Phys 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatrics, University of California, San Francisco, CA, USA.

Purpose: Radiation dose calculated on tumors for radiopharmaceutical therapy varies significantly from tumor to tumor and from patient to patient. Accurate estimation of radiation dose requires multiple time-point measurements using radionuclide imaging modalities such as SPECT or PET. In this report, we show our technical development of reducing the number of scans needed for reasonable estimation of tumor and normal organ dose in our pretherapy imaging and dosimetry platform of I-metaiodobenzylguanidine (MIBG) PET/CT for I-MIBG therapy of neuroblastoma. Read More

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http://dx.doi.org/10.1002/mp.13446DOI Listing
February 2019

Elucidating the inhibitory potential of Vitamin A against fibrillation and amyloid associated cytotoxicity.

Int J Biol Macromol 2019 Feb 7. Epub 2019 Feb 7.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. Electronic address:

Protein aggregation and amyloid fibrillation are associated with many serious human pathophysiologies like Alzheimer's, Parkinson's diseases, type II diabetes etc. A powerful strategy for controlling and understanding amyloid protein aggregation is the modulation of protein self-assembly. In this study, anti-fibrillation activity of vitamin A (VA) and its effect on the kinetics of amyloid formation of Aβ-42 peptide was investigated by employing various spectroscopic, imaging and computational approaches. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.134DOI Listing
February 2019

Esthesioneuroblastoma: An Unusual Presentation with Intractable Headache.

Cureus 2018 Nov 28;10(11):e3653. Epub 2018 Nov 28.

Radiology, Osceola Regional Medical Center, Kissimmee, USA.

Esthesioneuroblastoma, also known as olfactory neuroblastoma, is a malignant tumor of the upper nasal cavity. This report illustrates the case of a 63-year-old woman who presented with intractable headaches. Subsequent radiologic evaluation and correlation with histopathologic analysis confirmed esthesioneuroblastoma. Read More

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http://dx.doi.org/10.7759/cureus.3653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351115PMC
November 2018
1 Read

SCAPER localizes to primary cilia and its mutation affects cilia length, causing Bardet-Biedl syndrome.

Eur J Hum Genet 2019 Feb 5. Epub 2019 Feb 5.

The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Beer Sheva, Israel.

Studies of ciliopathies have served in elucidating much of our knowledge of structure and function of primary cilia. We report humans with Bardet-Biedl syndrome who display intellectual disability, retinitis pigmentosa, obesity, short stature and brachydactyly, stemming from a homozyogous truncation mutation in SCAPER, a gene previously associated with mitotic progression. Our findings, based on linkage analysis and exome sequencing studies of two remotely related large consanguineous families, are in line with recent reports of SCAPER variants associated with intellectual disability and retinitis pigmentosa. Read More

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http://www.nature.com/articles/s41431-019-0347-z
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http://dx.doi.org/10.1038/s41431-019-0347-zDOI Listing
February 2019
9 Reads

Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting α-glucosidase on cell membranes.

Bioorg Med Chem 2019 Mar 28;27(5):859-864. Epub 2019 Jan 28.

Department of Bioscience and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.

Molecules designed for cell-specific imaging were studied, taking advantage of an enzyme-inhibitor interaction. 1-Deoxynojirimycin (DNJ) can be actively captured by cells which express the surface membrane protein α-glucosidase. New probes composed of DNJ for recognition linked to a fluorophore signal portion were prepared (DNJ-CF1, DNJ-Dans 2 and DNJ-DEAC 3). Read More

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http://dx.doi.org/10.1016/j.bmc.2019.01.032DOI Listing
March 2019
1 Read

Overcoming Biological Barriers in Neuroblastoma Therapy: The Vascular Targeting Approach with Liposomal Drug Nanocarriers.

Small 2019 Feb 1:e1804591. Epub 2019 Feb 1.

Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy.

Neuroblastoma is a rare pediatric cancer characterized by a wide clinical behavior and adverse outcome despite aggressive therapies. New approaches based on targeted drug delivery may improve efficacy and decrease toxicity of cancer therapy. Furthermore, nanotechnology offers additional potential developments for cancer imaging, diagnosis, and treatment. Read More

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http://dx.doi.org/10.1002/smll.201804591DOI Listing
February 2019
1 Read

Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study.

Eur Radiol Exp 2019 Jan 30;3(1). Epub 2019 Jan 30.

Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Schweitzer-Allee 23, 89081, Ulm, Germany.

Background: Quantitative diffusion-weighted imaging (DWI) probes into tissue microstructure in solid tumours. In this retrospective ethically approved study, we investigated DWI as a potential non-invasive predictor of tumour dignity and prognosis in paediatric patients with neuroblastic tumours.

Methods: Nineteen consecutive patients with neuroblastoma (NB, n = 15), ganglioneuroblastoma (GNB, n = 1) and ganglioneuroma (GN, n = 3) underwent 3-T magnetic resonance imaging at first diagnosis and after 3-month follow-up, following a protocol including DWI (b = 50 and 800 s/mm) in addition to standard sequences. Read More

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http://dx.doi.org/10.1186/s41747-019-0087-4DOI Listing
January 2019

Neuroblastoma-targeting triangular gadolinium oxide nanoplates for precise excision of cancer.

Acta Biomater 2019 Jan 19. Epub 2019 Jan 19.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Beijing Key Laboratory Molecular Imaging, Beijing 100190, China; The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100080, China. Electronic address:

Neuroblastoma accounts for 8-10% of malignancies in infants and children. It is urgent to develop an appropriate theranostic agent for effective diagnosis and therapy of neuroblastoma. Herein, we constructed RVG peptide and IRDye800-conjugated bovine serum albumin-coated triangular gadolinium oxide nanoplates (RVG&IRDye800-GdO TNs) as a targeting MRI agent for the diagnosis of neuroblastoma preoperation and a fluorescence imaging agent for the guidance of the precise excision of the neuroblastoma in surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193006
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http://dx.doi.org/10.1016/j.actbio.2019.01.042DOI Listing
January 2019
3 Reads

Statistical Framework in Support of a Revised Children's Oncology Group Neuroblastoma Risk Classification System.

JCO Clin Cancer Inform 2018 12;2:1-15

Arlene Naranjo, University of Florida, Gainesville, FL; Meredith S. Irwin, Hospital for Sick Children, Toronto, ON, Canada; Michael D. Hogarty, University of Pennsylvania, Philadelphia, PA; Susan L. Cohn, The University of Chicago, Chicago, IL; Julie R. Park, University of Washington, Seattle, WA; and Wendy B. London, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA.

Purpose: The International Neuroblastoma Risk Group (INRG) Staging System (INRGSS) was developed through international consensus to provide a presurgical staging system that uses clinical and imaging data at diagnosis. A revised Children's Oncology Group (COG) neuroblastoma (NB) risk classification system is needed to incorporate the INRGSS and within the context of modern therapy. Herein, we provide statistical support for the clinical validity of a revised COG risk classification system. Read More

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http://dx.doi.org/10.1200/CCI.17.00140DOI Listing
December 2018
3 Reads

A novel tryptamine-appended rhodamine-based chemosensor for selective detection of Hg present in aqueous medium and its biological applications.

Anal Bioanal Chem 2019 Feb 9;411(6):1143-1157. Epub 2019 Jan 9.

Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata, 700 009, India.

A novel rhodamine-tryptamine conjugate-based fluorescent and chromogenic chemosensor (RTS) for detection of Hg present in water was reported. After gradual addition of Hg in aqueous methanol solution of RTS, a strong orange fluorescence and deep-pink coloration were observed. The probe showed high selectivity towards Hg compared to other competitive metal ions. Read More

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http://dx.doi.org/10.1007/s00216-018-1546-0DOI Listing
February 2019
1 Read
3.436 Impact Factor

Calreticulin regulates MYCN expression to control neuronal differentiation and stemness of neuroblastoma.

J Mol Med (Berl) 2019 Jan 5. Epub 2019 Jan 5.

Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan.

Oncogenic N-MYC (MYCN) is widely used as a biomarker in clinics for neuroblastoma (NB) patients; nevertheless, mechanism that underlines MYCN regulation remains elusive. In the present study, we identified calreticulin (CRT) as a novel MYCN suppressor that downregulated MYCN promoter activity and protein expression to modulate neuronal differentiation and stemness. Our data showed that CRT-mediated MYCN suppression led to increased neurite length and commensurate elevation in differentiation marker GAP-43. Read More

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http://dx.doi.org/10.1007/s00109-018-1730-xDOI Listing
January 2019

Neuroblastoma of the Bone and Bone Marrow Without an Apparent Primary Site: Report of 4 Cases With Long-term Follow-up.

Pediatr Dev Pathol 2019 Jan 2:1093526618822597. Epub 2019 Jan 2.

1 Division of Hematology-Oncology, Department of Pediatrics, Texas Children's Cancer & Hematology Centers, Baylor College of Medicine, Houston, Texas.

Children with neuroblastoma rarely present with metastatic disease without identifiable primary tumors. We describe the clinical and histopathologic characteristics of 4 patients aged 1, 7, 7, and 11 years with neuroblastoma involving bone or bone marrow without an apparent primary site. One patient presented with a periorbital bone lesion, 1 presented with a distal femoral lesion, and 2 presented with diffuse bone marrow involvement. Read More

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http://journals.sagepub.com/doi/10.1177/1093526618822597
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http://dx.doi.org/10.1177/1093526618822597DOI Listing
January 2019
2 Reads

Recurrent bloody stools associated with visceral infantile haemangioma in a preterm twin girl.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Neonatology, University of Washington, Seattle, Washington, USA.

A premature twin infant girl was transferred to a level IV neonatal intensive care unit for recurrent bloody stools, anaemia and discomfort with feeds; without radiographic evidence of necrotising enterocolitis. Additional imaging after transfer revealed a large retroperitoneal mass in the region of the pancreas compressing the inferior vena cava and abdominal aorta, raising suspicion for neuroblastoma. Abdominal exploration and biopsy unexpectedly revealed that the lesion was an infantile capillary haemangioma involving the small bowel, omentum, mesentery and pancreas. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226564
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http://dx.doi.org/10.1136/bcr-2018-226564DOI Listing
December 2018
4 Reads

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.

Clin Cancer Res 2018 Dec 18. Epub 2018 Dec 18.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana.

Checkpoint kinase 1 (CHK1) inhibitors potentiate the DNA-damaging effects of cytotoxic therapies and/or promote elevated levels of replication stress, leading to tumor cell death. Prexasertib (LY2606368) is a CHK1 small-molecule inhibitor under clinical evaluation in multiple adult and pediatric cancers. In this study, prexasertib was tested in a large panel of preclinical models of pediatric solid malignancies alone or in combination with chemotherapy. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2728DOI Listing
December 2018
1 Read

Surgical removal of adult recurrent neuroblastoma located in the posterior mediastinum and retroperitoneum: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13642

Department of Hepatobiliary Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.

Rationale: Adult recurrent neuroblastoma is extremely rare, especially in the posterior mediastinum and retroperitoneal cavity. The surgical treatment of this special part of the tumor is also a clinical difficulty.

Patient Concerns: This study reports a case of a 24-year-old man with a history of treated posterior mediastinal neuroblastoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320002PMC
December 2018

[Cu]CuCl PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis.

Theranostics 2018 9;8(20):5645-5659. Epub 2018 Nov 9.

Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, NSW, Australia 2031.

Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, copper homeostasis is considered as an emerging target for anticancer drug design. Monitoring copper levels is therefore of paramount importance when assessing the efficacy of copper-targeting drugs. Herein, we investigated the activity of the copper-targeting compound Dextran-Catechin by developing a [Cu]CuCl PET imaging protocol to monitor its effect on copper homeostasis in tumors. Read More

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http://www.thno.org/v08p5645.htm
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http://dx.doi.org/10.7150/thno.29840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276294PMC
November 2018
7 Reads

Molecular Scaffolds as Double-Targeting Agents For the Diagnosis and Treatment of Neuroblastoma.

Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.

Dpto. Química en Ciencias Farmacéuticas., Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n., Spain.

The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as one of the most important challenges in the nanomedicine field. Meta-iodobenzilguanidine (MIBG) is widely used for the diagnosis of neuroblastoma (NB) due to its strong affinity for the norepinephrine transporter (NET), usually overexpressed on the membrane of malignant cells. Herein, a family of novel Y-shaped scaffolds has been synthesized, which have structural analogues of MIBG covalently attached at each end of the Y-structure. Read More

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http://dx.doi.org/10.1002/anie.201811691DOI Listing
December 2018
2 Reads

Treatment-related Focal Nodular Hyperplasia Mimicking Liver Metastases.

J Pediatr Hematol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Departments of Radiology.

A 7-year-old patient with a stage 4 neuroblastoma underwent chemotherapy, surgery, myeloablative therapy, external beam radiotherapy, and Isoretinoin treatment. A posttreatment magnetic resonance examination performed administering gadoteric acid as contrast agent showed 2 new hypervascular hepatic lesions, suspicious for metastases. A second magnetic resonance imaging performed using a liver-specific contrast medium (gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid) demonstrated that these lesions were consistent with treatment-related focal nodular hyperplasia. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001362DOI Listing
November 2018
1 Read

Different Efflux Transporter Affinity and Metabolism of Tc-2-Methoxyisobutylisonitrile and Tc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer.

Pharm Res 2018 Nov 29;36(1):18. Epub 2018 Nov 29.

School of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Background: Little is known about the affinity and stability of Tc-labeled 2-methoxyisobutylisonitrile (Tc-MIBI) and tetrofosmin (Tc-TF) for imaging of multiple drug resistance transporters in cancer. We examined the affinity of Tc-labeled compounds for these transporters and their stability.

Methods: Tc-MIBI and Tc-TF were incubated in vesicles expressing P-glycoprotein (MDR1), multidrug resistance-associated protein (MRP)1-4, or breast cancer resistance protein with and without verapamil (MDR1 inhibitor) or MK-571 (MRP inhibitor). Read More

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http://dx.doi.org/10.1007/s11095-018-2548-5DOI Listing
November 2018
2 Reads
3.420 Impact Factor

Implications of Image-Defined Risk Factors and Primary Site Response on Local Control and Radiation Treatment Delivery in the Management of High Risk Neuroblastoma: Is there a Role for De-escalation of Adjuvant Primary Site Radiotherapy?

Int J Radiat Oncol Biol Phys 2018 Nov 26. Epub 2018 Nov 26.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: The predictive value of Image-Defined Risk Factors (IDRFs) developed by the International Neuroblastoma Risk Group (INRG) Task Force as it relates to primary site management is undefined and may aid patient selection for de-escalation of adjuvant radiotherapy to the primary site in high risk neuroblastoma (HRNB).

Methods: Patients (N=76) with HRNB treated on prospective trials at our institution from 1997 to 2014 were eligible for inclusion. IDRFs were defined based on pre-therapy imaging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183402
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http://dx.doi.org/10.1016/j.ijrobp.2018.11.041DOI Listing
November 2018
10 Reads

Assessment of the dicentric chromosome assay as a biodosimetry tool for more personalized medicine in a case of a high risk neuroblastoma I-mIBG treatment.

Int J Radiat Biol 2018 Nov 29:1-13. Epub 2018 Nov 29.

a Radiation Protection Service , Hospital Universitario y Politécnico La Fe , Spain .

Purpose The aims of this study were to estimate the whole-body absorbed-dose with the Dicentric Chromosome Assay (DCA) (biodosimetry) for I-metaiodobenzylguanidine (I-mIBG) therapy for high-risk neuroblastoma, and to obtain an initial correlation with the physical dosimetry calculated as described by the Medical Internal Radiation Dosimetry formalism (MIRD). Together both objectives will aidobjectives will aid the optimization of personalized targeted radionuclide therapies. Material and Methods A 12 year-old child with relapsed high-risk neuroblastoma was treated with I-mIBG: a first administration with activity <444 MBq/kg was used as a tracer in order to calculate the activity needed in a second administration to achieve a whole body prescribed dose of approximately 4 Gy. Read More

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http://dx.doi.org/10.1080/09553002.2019.1549755DOI Listing
November 2018
1 Read

Lymph node imaging of pediatric renal and suprarenal malignancies.

Transl Androl Urol 2018 Oct;7(5):774-782

Department of Urology, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Pediatric renal and suprarenal cancers are relatively rare malignancies, but are not without significant consequence to both the patient and caretakers. These tumors are often found incidentally and present as large abdominal masses. Standard of care management involves surgical excision of the mass, but contemporary treatment guidelines advocate for use of neoadjuvant or adjuvant chemotherapy for advanced stage disease, such as those cases with lymph node involvement (LNI). Read More

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http://dx.doi.org/10.21037/tau.2018.07.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212619PMC
October 2018
16 Reads

Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma.

Theranostics 2018 6;8(18):5106-5125. Epub 2018 Oct 6.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

In recent reports, we have shown that optimized pretargeted radioimmunotherapy (PRIT) based on molecularly engineered antibody conjugates and Lu-DOTA chelate (DOTA-PRIT) can be used to cure mice bearing human solid tumor xenografts using antitumor antibodies to minimally internalizing membrane antigens, GPA33 (colon) and GD2 (neuroblastoma). However, many solid tumor membrane antigens are internalized after antibody binding and it is generally believed that internalizing tumor membrane antigens are not suitable targets for PRIT. In this study, we tested the hypothesis that DOTA-PRIT can be performed successfully to target HER2, an internalizing membrane antigen widely expressed in breast, ovarian, and gastroesophageal junction cancers. Read More

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http://www.thno.org/v08p5106.htm
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http://dx.doi.org/10.7150/thno.26585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217068PMC
October 2018
13 Reads

Magnetic Resonance Imaging for Characterization of a Chick Embryo Model of Cancer Cell Metastases.

Mol Imaging 2018 Jan-Dec;17:1536012118809585

1 Department of Biochemistry, University of Liverpool, Liverpool, United Kingdom.

Metastasis is the most common cause of death for patients with cancer. To fully understand the steps involved in metastatic dissemination, in vivo models are required, of which murine ones are the most common. Therefore, preclinical imaging methods such as magnetic resonance imaging (MRI) have mainly been developed for small mammals and their potential to monitor cancer growth and metastasis in nonmammalian models is not fully harnessed. Read More

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http://dx.doi.org/10.1177/1536012118809585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236852PMC
February 2019
8 Reads

Ectopic adrenocorticotropic hormone syndrome associated with olfactory neuroblastoma: acquirement of adrenocorticotropic hormone expression during disease course as shown by serial immunohistochemistry examinations.

J Int Med Res 2018 Nov;46(11):4760-4768

1 Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Hyogo, Japan.

Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a condition of endogenous hypercortisolism sustained by an extrapituitary ACTH-secreting tumor. Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of the sinonasal tract and is derived from the olfactory epithelium. Because the paranasal sinus is not a common site of EAS, the development of ONB in patients with EAS is rare. Read More

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http://journals.sagepub.com/doi/10.1177/0300060517754026
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http://dx.doi.org/10.1177/0300060517754026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259372PMC
November 2018
8 Reads

Ocular flutter as presenting manifestation of pediatric MOG antibody-associated demyelination: A case report.

Mult Scler 2018 Oct 31:1352458518771872. Epub 2018 Oct 31.

Neurology Department, Penteli Children's Hospital, Attica, Greece.

A 13-year-old girl presented with a 5-day history of oscillopsia. On examination, ocular flutter and mild cerebellar signs were found. Brain magnetic resonance imaging (MRI) revealed four periventricular and subcortical non-enhancing lesions. Read More

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http://dx.doi.org/10.1177/1352458518771872DOI Listing
October 2018
3 Reads

Three-Dimensional Printed Model and Virtual Reconstruction: An Extra Tool for Pediatric Solid Tumors Surgery.

European J Pediatr Surg Rep 2018 Jan 18;6(1):e70-e76. Epub 2018 Oct 18.

Department of Pediatric Surgery, Clinical University Hospital Virgen de la Arrixaca, Murcia, Spain.

 Three-dimensional (3D) technology is increasingly applied for planning challenging surgical interventions. We report our experience using 3D printing and virtual reconstruction for surgical planning of complex tumor resections in children.  Data were obtained from preoperative magnetic resonance. Read More

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http://dx.doi.org/10.1055/s-0038-1672165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202581PMC
January 2018
1 Read

Value of SPECT/CT in Diagnostic I-131 MIBG Scintigraphy in Patients with Neuroblastoma.

Nucl Med Mol Imaging 2018 Oct 16;52(5):350-358. Epub 2018 Jul 16.

Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, 123 Mittraparp highway, Muang, Khon Kaen, 40002 Thailand.

Purpose: Diagnostic I-131 MIBG scintigraphy is an important imaging modality for evaluation of patients with neuroblastoma (NB) especially in centers where I-123 MIBG is not available. Single photon emission computed tomography/computed tomography (SPECT/CT) could potentially improve lesion detection over planar scintigraphy, but studies regarding its usefulness as an add-on to diagnostic I-131 MIBG scintigraphy are limited. This study aimed to determine the usefulness and factors related to usefulness of SPECT/CT in diagnostic I-131 MIBG scintigraphy in NB patients. Read More

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http://link.springer.com/10.1007/s13139-018-0532-y
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http://dx.doi.org/10.1007/s13139-018-0532-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177351PMC
October 2018
8 Reads

Laparoscopy as a Primary Investigatory Tool in Pediatric Abdominal Masses.

Gulf J Oncolog 2018 Sep;1(28):52-55

Division of Pediatric Surgery; Dept. of Surgery, College of Medicine, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.

Background: Management of abdominal masses still pose a major challenge for pediatrician and surgeons with many controversy as regards the best investigatory tools.

Aim Of The Work: This study was designated to evaluate the role of diagnostic laparoscopy in investigating equivocal pediatric masses that had undergone other imaging modalities.

Patients And Methods: A combined prospective and retrospective multicenter study over a period of 12 years from January 2005 to December 2016 was undertaken. Read More

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September 2018
13 Reads

Prevalence and Clinical Correlations of Somatostatin Receptor-2 (SSTR2) Expression in Neuroblastoma.

J Pediatr Hematol Oncol 2018 Oct 16. Epub 2018 Oct 16.

Departments of Pediatrics, Division of Hematology/Oncology.

Alternative radiolabeled, targeted agents are being investigated for children with relapsed neuroblastoma (NB) who do not respond to I-metaiodobenzylguanidine (MIBG) therapy. (DOTA-Tyr)-octreotate targets somatostatin receptors (SSTRs), particularly SSTR2, which are expressed on NB cells. We investigated SSTR2 expression in NB tumors (36 high-risk [HR]; 33 non-HR patients) and correlated SSTR2 levels with clinical features, norepinephrine transporter (NET) expression, and MIBG avidity. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001326DOI Listing
October 2018

The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death.

Br J Cancer 2018 Nov 15;119(10):1278-1287. Epub 2018 Oct 15.

Department of Surgery and Cancer, Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

Background: Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A.

Methods: Autophagy substrates (light chain-3 (LC-3) and p62 proteins) and endoplasmic reticulum (ER) stress phenotype were determined. Read More

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http://dx.doi.org/10.1038/s41416-018-0232-5DOI Listing
November 2018
2 Reads

I-131 mIBG Scintigraphy Curie Versus SIOPEN Scoring: Prognostic Value in Stage 4 Neuroblastoma

Mol Imaging Radionucl Ther 2018 Oct;27(3):121-125

Canal Bank, Clinic of Surgery, Lahore, Pakistan

Objective: I-131 mIBG scan semi-quantitative analysis with modified Curie and the International Society of Pediatric Oncology Europe Neuroblastoma (SIOPEN) scoring systems is helpful in the evaluation of disease extent and has prognostic impact in stage 4 neuroblastoma.

Methods: Retrospective, cross-sectional analysis of baseline I-131 mIBG scans in 21 patients with stage 4 or 4S neuroblastoma diagnosed between January 2007 and December 2015. All scans were assessed for Curie and SIOPEN scores. Read More

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http://cms.galenos.com.tr/Uploads/Article_19779/MIRT-27-121-
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http://dx.doi.org/10.4274/mirt.52533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191737PMC
October 2018
1 Read

Approach to pediatric renal tumors: an imaging review.

Abdom Radiol (NY) 2018 Oct 11. Epub 2018 Oct 11.

Department of Radiology and Imaging, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 110029, India.

Renal tumors comprise 7% of all childhood cancers. A wide variety of renal tumors can affect the pediatric kidneys, which can be broadly classified as primary benign tumors, primary malignant tumors, and metastatic lesions. This article aims to enumerate usual benign and malignant renal tumors that can occur in childhood and emphasizes the characteristic imaging appearances which aid in their differential diagnosis. Read More

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http://link.springer.com/10.1007/s00261-018-1773-z
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http://dx.doi.org/10.1007/s00261-018-1773-zDOI Listing
October 2018
3 Reads

CT and MRI of adrenal gland pathologies.

Quant Imaging Med Surg 2018 Sep;8(8):853-875

Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.

Besides ultrasound and nuclear medicine techniques, computed tomography (CT) and magnetic resonance imaging (MRI) are commonly used to examine adrenal lesions in both symptomatic and asymptomatic patients. Some adrenal lesions have characteristic radiological features. If an adrenal nodule is discovered incidentally, determining whether the lesion is benign or malignant is of great importance. Read More

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http://qims.amegroups.com/article/view/21428/21140
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http://dx.doi.org/10.21037/qims.2018.09.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177362PMC
September 2018
16 Reads

Improved, one-pot synthesis of 6-[ F]fluorodopamine and quality control testing for use in patients with neuroblastoma.

J Labelled Comp Radiopharm 2018 Dec 22;61(14):1069-1080. Epub 2018 Oct 22.

Division of Nuclear Medicine, Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

6-[ F]Fluorodopamine ([ F]F-DA) is taken into cells via the norepinephrine transporter (NET). Recent [ F]F-DA positron emission tomography-computed tomography (PET-CT) imaging of adult neuroendocrine tumors shows a dramatic improvement in sensitivity over the standard-of-care, meta-iodobenzylguanidine (MIBG) single-photon emission computed tomography (SPECT)-CT. A new precursor (ALPdopamine™) allows no-carrier-added synthesis resulting in high-molar activity [ F]F-DA. Read More

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http://doi.wiley.com/10.1002/jlcr.3685
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http://dx.doi.org/10.1002/jlcr.3685DOI Listing
December 2018
2 Reads

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch".

J Biol Chem 2018 Nov 4;293(47):18270-18284. Epub 2018 Oct 4.

From the Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 6, Ireland

In response to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, three ER transmembrane signaling proteins, inositol-requiring enzyme 1 (IRE1), PRKR-like ER kinase (PERK), and activating transcription factor 6α (ATF6α), are activated. These proteins initiate a signaling and transcriptional network termed the unfolded protein response (UPR), which re-establishes cellular proteostasis. When this restoration fails, however, cells undergo apoptosis. Read More

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http://dx.doi.org/10.1074/jbc.RA118.002121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254332PMC
November 2018
9 Reads

Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.

Anticancer Res 2018 Oct;38(10):5627-5634

Department of Pathology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

Background: Genetic alterations occurring in lung cancer are the basis for defining molecular subtypes and essential for targeted therapies. Exhaled breath condensate (EBC) is a form of non-invasive sample that, amongst components, contains DNA from pulmonary tissue. Next-generation sequencing (NGS) was herein used to analyze mutations in EBC from patients with lung cancer. Read More

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http://dx.doi.org/10.21873/anticanres.12897DOI Listing
October 2018
5 Reads

Managing local-regional failure in children with high-risk neuroblastoma: A single institution experience.

Pediatr Blood Cancer 2018 Dec 30;65(12):e27408. Epub 2018 Sep 30.

Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Intensification of systemic therapy for high-risk neuroblastoma (HRNB) has resulted in improved local control and overall survival (OS) leaving potential for de-escalation of primary site radiotherapy. The utility of primary site de-escalation should be evaluated in the context of potential for successful local-regional salvage. We evaluated salvage strategies and outcomes in patients with HRNB with local-regional recurrence as a component of first failure. Read More

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http://dx.doi.org/10.1002/pbc.27408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192847PMC
December 2018
10 Reads

Primary osseous sacral neuroblastoma in an adult.

Skeletal Radiol 2018 Sep 30. Epub 2018 Sep 30.

Musculoskeletal Imaging and Interventions Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.

Neoplasms of the sacrum are rare. Given the non-specific imaging findings in sacral lesions, the imaging-based differential diagnosis is always difficult. This case is about an adult with primary sacral neuroblastoma and we have discussed imaging and histopathological findings of this rare tumor. Read More

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http://link.springer.com/10.1007/s00256-018-3081-7
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http://dx.doi.org/10.1007/s00256-018-3081-7DOI Listing
September 2018
13 Reads

Practical Application of the International Neuroblastoma Risk Group Staging System: A Pictorial Review.

Curr Probl Diagn Radiol 2018 Sep 1. Epub 2018 Sep 1.

Department of Radiology, Texas Children's Hospital, Houston, TX; Department of Radiology, Stanford University School of Medicine, Stanford, CA; Center for Pediatric and Maternal Value, Lucile Packard Children's Hospital at Stanford, Stanford, CA. Electronic address:

Because of issues with the previous staging system, the International Neuroblastoma Risk Group Staging System (INRG-SS) was created in 2009. The INRG-SS is based on preoperative imaging, rather than surgical, staging and emphasizes Imaging-Defined Risk Factors as the determining factors between L1 and L2 stages. Like with the introduction of any new tool, based on the authors' experience, there has been a time-lag related to adoption of the INRG-SS staging system by radiologists. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03630188183020
Publisher Site
http://dx.doi.org/10.1067/j.cpradiol.2018.08.008DOI Listing
September 2018
2 Reads

[Minimally invasive surgery of neural tumors in childhood].

Cir Pediatr 2018 Aug 3;31(3):140-145. Epub 2018 Aug 3.

Hospital Universitario y Politécnico La Fe. Valencia.

Purpouse: The aim of the paper is to describe the experience in our center with the use of minimally invasive surgery (MIS) of neural tumors in childhood.

Methods: Descriptive and retrospective study of patients diagnosed with neural neoplasia (neuroblastoma and neuroganglioma) on whom MIS technique surgery has been performed between October 2012 and December 2017. The inclusion criteria were patients with a neural tumor diagnosis who, at the time of the intervention, did not have imaging-defined risk factors (IDRFs). Read More

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August 2018
10 Reads

Does Urinary Tract Ultrasound Have Its Place in the Treatment of Early Neonatal Jaundice? Neonatal Bilateral Adrenal Hemorrhage: Case Report.

Acta Clin Croat 2018 Mar;57(1):161-165

Department of Pediatrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

Adrenal hemorrhage is a rare clinical entity in the neonatal period, with an incidence of 1.7-2.1/1000 births. Read More

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http://dx.doi.org/10.20471/acc.2018.57.01.21DOI Listing
March 2018
3 Reads

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.

Proc Natl Acad Sci U S A 2018 10 24;115(41):10481-10486. Epub 2018 Sep 24.

Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain;

Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons, a process that current therapeutic approaches cannot prevent. In PD, the typical pathological hallmark is the accumulation of intracellular protein inclusions, known as Lewy bodies and Lewy neurites, which are mainly composed of α-synuclein. Here, we exploited a high-throughput screening methodology to identify a small molecule (SynuClean-D) able to inhibit α-synuclein aggregation. Read More

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http://dx.doi.org/10.1073/pnas.1804198115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187188PMC
October 2018
2 Reads

Pediatric opsoclonus-myoclonus-ataxia syndrome: Experience from a tertiary care university hospital.

Neurol India 2018 Sep-Oct;66(5):1332-1337

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.

Background: Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare disorder; there is limited experience regarding its clinical course and therapeutic response.

Aims And Objectives: To describe the clinical profile, investigations, and therapeutic outcome in pediatric OMAS.

Patients And Methods: Fourteen children (age: 27. Read More

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http://dx.doi.org/10.4103/0028-3886.241404DOI Listing
September 2018

Radiological review of skull lesions.

Insights Imaging 2018 Oct 19;9(5):857-882. Epub 2018 Sep 19.

Department of Imaging Sciences, University of Rochester, 601 Elmwood Avenue, Rochester, NY, 14602, USA.

Calvarial lesions are often asymptomatic and are usually discovered incidentally during computed tomography or magnetic resonance imaging of the brain. Calvarial lesions can be benign or malignant. Although the majority of skull lesions are benign, it is important to be familiar with their imaging characteristics and to recognise those with malignant features where more aggressive management is needed. Read More

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http://dx.doi.org/10.1007/s13244-018-0643-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206383PMC
October 2018
2 Reads

Activated Natural Killer Cells in Combination with Anti-GD2 Antibody Dinutuximab Improve Survival of Mice after Surgical Resection of Primary Neuroblastoma.

Clin Cancer Res 2019 Jan 19;25(1):325-333. Epub 2018 Sep 19.

Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California.

Purpose: Immunotherapy of neuroblastoma that remains after myeloablative chemotherapy with anti-GD2 antibody dinutuximab has increased the two-year event-free and overall survival of high-risk neuroblastoma patients; however, 40% of patients develop recurrent disease during or after this treatment. To determine the potential of such antibody-based immunotherapy earlier in treatment, a mouse model was developed in which surgical resection of the primary tumor was followed by therapy of residual disease with dinutuximab combined with -activated human natural killer (aNK) cells.

Experimental Design: The effect of combining dinutuximab with human aNK cells was determined with cellular cytotoxicity and Matrigel invasion assays. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320320PMC
January 2019
3 Reads

Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases.

Sci Rep 2018 Sep 18;8(1):13986. Epub 2018 Sep 18.

Institute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

Metastasis formation is the major cause for cancer-related deaths and the underlying mechanisms remain poorly understood. In this study we describe spontaneous metastasis xenograft mouse models of human neuroblastoma used for unbiased identification of metastasis-related proteins by applying an infrared laser (IR) for sampling primary tumor and metastatic tissues, followed by mass spectrometric proteome analysis. IR aerosol samples were obtained from ovarian and liver metastases, which were indicated by bioluminescence imaging (BLI), and matched subcutaneous primary tumors. Read More

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http://dx.doi.org/10.1038/s41598-018-32236-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143537PMC
September 2018

Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma.

Pediatr Blood Cancer 2018 Dec 10;65(12):e27417. Epub 2018 Sep 10.

Department of Pediatrics, The University of Chicago, Chicago, Illinois.

Background: Radiolabeled metaiodobenzylguanidine (MIBG) is sensitive and specific for detecting neuroblastoma. The extent of MIBG-avid disease is assessed using Curie scores. Although Curie scoring is prognostic in patients with high-risk neuroblastoma, there is no standardized method to assess the response of specific sites of disease over time. Read More

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http://dx.doi.org/10.1002/pbc.27417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317352PMC
December 2018
1 Read

Imaging pH Dynamics Simultaneously in Two Cellular Compartments Using a Ratiometric pH-Sensitive Mutant of mCherry.

ACS Omega 2018 Aug 20;3(8):9476-9486. Epub 2018 Aug 20.

Department of Chemistry, Institute for Integrative Neuroscience, and Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, 560 Oval Drive, P.O. Box 68, West Lafayette, Indiana 47907, United States.

The regulation of pH is essential for proper organelle function, and organelle-specific changes in pH often reflect the dynamics of physiological signaling and metabolism. For example, mitochondrial energy production depends on the proton gradient maintained between the alkaline mitochondrial matrix and neutral cytosol. However, we still lack a quantitative understanding of how pH dynamics are coupled between compartments and how pH gradients are regulated at organelle boundaries. Read More

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http://dx.doi.org/10.1021/acsomega.8b00655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120727PMC
August 2018
1 Read