45,454 results match your criteria Neuroblastoma

Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation.

Neurobiol Dis 2022 Jun 21;171:105799. Epub 2022 Jun 21.

Departments of Physiology & Biophysics, University of California, Irvine, CA 92697, United States of America; Medicine, School of Medicine, University of California, Irvine, CA 92697, United States of America; Department of Veteran Affairs, VA Medical Center, Long Beach, CA 90822, United States of America. Electronic address:

Alzheimer's disease (AD) is a neurodegenerative disease characterized by Amyloid-β peptide (Aβ) containing plaques and cognitive deficits. The pathophysiology of AD also involves neuroinflammation. Vitamin B1 (thiamin) is indispensable for normal cellular energy metabolism. Read More

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Aβ peptide toxicity on neuronal cells: A lipidomic study.

J Pharm Biomed Anal 2022 Jun 6;219:114876. Epub 2022 Jun 6.

Department for Life Quality Studies, University of Bologna, Corso D' Augusto 237, 47921 Rimini, Italy. Electronic address:

Currently Alzheimer's Disease (AD) pathological pathways, which lead to cell death and dementia, are not completely well-defined; in particular, the lipid changes in brain tissues that begin years before AD symptoms. Due to the central role of the amyloid aggregation process in the early phase of AD pathogenesis, we aimed at developing a lipidomic approach to evaluate the amyloid toxic effects on differentiated human neuroblastoma derived SH-SY5Y cells. First of all, this work was performed to highlight qualitative and relative quantitative lipid variations in connection with amyloid toxicity. Read More

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Independent Cis-Regulatory Modules within the Herpes Simplex Virus 1 Infected Cell Protein 0 (ICP0) Promoter Are Transactivated by Krüppel-like Factor 15 and Glucocorticoid Receptor.

Viruses 2022 Jun 13;14(6). Epub 2022 Jun 13.

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 208 N McFarland Street, RM 250 McElroy Hall, Stillwater, OK 74078, USA.

A corticosteroid antagonist impairs Herpes Simplex Virus 1 (HSV-1) productive infection and explant-induced reactivation from latency, suggesting corticosteroids and the glucocorticoid receptor (GR) mediate certain aspects of these complex virus-host interactions. GR-hormone complexes regulate transcription positively and negatively, in part, by binding GR response elements (GREs). Recent studies revealed infected cell protein 0 (ICP0), ICP4, and ICP27 promoter/cis-regulatory modules (CRMs) are cooperatively transactivated by GR and Krüppel-like factor 15 (KLF15), which forms a feed-forward transcription loop. Read More

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Nanospermidine in Combination with Nanofenretinide Induces Cell Death in Neuroblastoma Cell Lines.

Pharmaceutics 2022 Jun 7;14(6). Epub 2022 Jun 7.

Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.

A new strategy to cause cell death in tumors might be the increase of intracellular polyamines at concentrations above their physiological values to trigger the production of oxidation metabolites at levels exceeding cell tolerance. To test this hypothesis, we prepared nanospermidine as a carrier for spermidine penetration into the cells, able to escape the polyamine transport system that strictly regulates intracellular polyamine levels. Nanospermidine was prepared by spermidine encapsulation in nanomicelles and was characterized by size, zeta potential, loading, dimensional stability to dilution, and stability to spermidine leakage. Read More

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Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents.

Pharmaceutics 2022 Jun 2;14(6). Epub 2022 Jun 2.

Hemato-Oncology Lab, Department of Woman's and Child's Health, University of Padova, 35131 Padova, Italy.

Two different series of fifty-two compounds, based on 3',4',5'-trimethoxyaniline () and variably substituted anilines () at the 7-position of the 2-substituted-[1,2,4]triazolo [1,5-]pyrimidine nucleus, had moderate to potent antiproliferative activity against A549, MDA-MB-231, HeLa, HT-29 and Jurkat cancer cell lines. All derivatives with a common 3-phenylpropylamino moiety at the 2-position of the triazolopyrimidine scaffold and different halogen-substituted anilines at its 7-position, corresponding to 4'-fluoroaniline (), 4'-fluoro-3'-chloroaniline (), 4'-chloroaniline () and 4'-bromoaniline (), displayed the greatest antiproliferative activity with mean ICs of 83, 101, 91 and 83 nM, respectively. These four compounds inhibited tubulin polymerization about 2-fold more potently than combretastatin A-4 (CA-4), and their activities as inhibitors of [H]colchicine binding to tubulin were similar to that of CA-4. Read More

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Acridone Derivatives from Inhibited Cancer Cell Proliferation through ERK Pathway.

Molecules 2022 Jun 16;27(12). Epub 2022 Jun 16.

Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.

The present study aimed to investigate the effect of acridone alkaloids on cancer cell lines and elucidate the underlying molecular mechanisms. The ten acridone alkaloids from were screened for cytotoxicity against LNCaP cell lines by a WST-8 assay. Then, the most potential acridone, buxifoliadine E, was evaluated on four types of cancer cells, namely prostate cancer (LNCaP), neuroblastoma (SH SY5Y), hepatoblastoma (HepG2), and colorectal cancer (HT29). Read More

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α-Synuclein A53T Promotes Mitochondrial Proton Gradient Dissipation and Depletion of the Organelle Respiratory Reserve in a Neuroblastoma Cell Line.

Life (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

we.MitoBiotech S.R.L., Corso Italia 172, 95125 Catania, Italy.

α-synuclein (αSyn) is a small neuronal protein whose accumulation correlates with Parkinson's disease. αSyn A53T mutant impairs mitochondrial functions by affecting substrate import within the organelle, activity of complex I and the maximal respiratory capacity. However, the precise mechanism initiating the bioenergetic dysfunction is not clearly understood yet. Read More

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Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application.

Int J Mol Sci 2022 Jun 13;23(12). Epub 2022 Jun 13.

Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Żeromskiego 116, 90-924 Łódź, Poland.

Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, which cause the highest mortality in humans. In this paper we describe a series of coordination compounds with the element of health, zinc, and bioactive ligands, benzimidazole derivatives. By way of synthesis we have obtained four compounds named , , and Analytical analyses (elemental analysis (EA), flame atomic absorption spectrometry (FAAS)), spectroscopic (Fourier transform infrared spectroscopy (FT-IR), mass spectrometry (MS)) and thermogravimetric (TG) methods and the definition of crystal structures were used to explore the nature of bonding and to elucidate the chemical structures. Read More

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Genomic Analysis Made It Possible to Identify Gene-Driver Alterations Covering the Time Window between Diagnosis of Neuroblastoma 4S and the Progression to Stage 4.

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.

Neuroblastoma (NB) is a tumor of the developing sympathetic nervous system. Despite recent advances in understanding the complexity of NB, the mechanisms that determine its regression or progression are still largely unknown. Stage 4S NB is characterized by a favorable course of disease and often by spontaneous regression, while progression to true stage 4 is a very rare event. Read More

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Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer's Disease.

Cells 2022 Jun 7;11(12). Epub 2022 Jun 7.

Laboratory of Neuroprotection and Autophagy, Faculty of Sciences, Universidad Mayor, Santiago 8580745, Chile.

Alzheimer's disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon is a well-established inhibitor of autophagy in all cells. Read More

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Low-Dose Metronomic Topotecan and Pazopanib (TOPAZ) in Children with Relapsed or Refractory Solid Tumors: A C17 Canadian Phase I Clinical Trial.

Cancers (Basel) 2022 Jun 17;14(12). Epub 2022 Jun 17.

The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.

Oral metronomic topotecan represents a novel approach to chemotherapy delivery which, in preclinical models, may work synergistically with pazopanib in targeting angiogenesis. A phase I and pharmacokinetic (PK) study of this combination was performed in children with relapsed/refractory solid tumors. Oral topotecan and pazopanib were each administered daily without interruption in 28-day cycles at five dose levels (0. Read More

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The Machine-Learning-Mediated Interface of Microbiome and Genetic Risk Stratification in Neuroblastoma Reveals Molecular Pathways Related to Patient Survival.

Cancers (Basel) 2022 Jun 10;14(12). Epub 2022 Jun 10.

Department of Basic Science, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.

Currently, most neuroblastoma patients are treated according to the Children's Oncology Group (COG) risk group assignment; however, neuroblastoma's heterogeneity renders only a few predictors for treatment response, resulting in excessive treatment. Here, we sought to couple COG risk classification with tumor intracellular microbiome, which is part of the molecular signature of a tumor. We determine that an intra-tumor microbial gene abundance score, namely M-score, separates the high COG-risk patients into two subpopulations (M and M) with higher accuracy in risk stratification than the current COG risk assessment, thus sparing a subset of high COG-risk patients from being subjected to traditional high-risk therapies. Read More

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Inhibitory Effectiveness in Delayed-Rectifier Potassium Current Caused by Vortioxetine, Known to Be a Novel Antidepressant.

Biomedicines 2022 Jun 3;10(6). Epub 2022 Jun 3.

Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.

Vortioxetine (VOR) is recognized to exert antidepressant actions. However, whether this drug modifies ionic currents in excitable cells remains unclear. The aim of this study was to explore the electrophysiological effects of VOR and other related compounds in pituitary GH cells and in Neuro-2a cells. Read More

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Influence of Molecular Structures on Fluorescence of Flavonoids and Their Detection in Mammalian Cells.

Biomedicines 2022 May 28;10(6). Epub 2022 May 28.

Laboratory of Molecular Neurophysiology, Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.

Flavonoids are being increasingly applied for the treatment of various diseases due to their anti-cancer, anti-oxidant, anti-inflammatory, and anti-viral properties. However, it is often challenging to detect their presence in cells and tissues through bioimaging, as most of them are not fluorescent or are too weak to visualize. Here, fluorescence possibilities of nine naturally occurring analogous flavonoids have been investigated through UV/visible spectroscopy, molecular structure examination, fluorescent images in mammalian cells and their statistical analysis employing aluminum chloride and diphenylboric acid 2-aminoethyl ester as fluorescence enhancers. Read More

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Silibinin Protects against HO-Induced Oxidative Damage in SH-SY5Y Cells by Improving Mitochondrial Function.

Antioxidants (Basel) 2022 May 31;11(6). Epub 2022 May 31.

CAS Key Laboratory of Tibetan Medicine Research, Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.

Oxidative stress plays a critical role in the pathogenesis of various neurodegenerative diseases. Increasing evidence suggests the association of mitochondrial abnormalities with oxidative stress-related neural damage. Silibinin, a natural flavonol compound isolated from , exhibits multiple biological activities. Read More

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Erratum: Three-dimensional In Vitro Biomimetic Model of Neuroblastoma using Collagen-based Scaffolds.


J Vis Exp 2022 Jul 23(185). Epub 2022 Jul 23.

An erratum was issued for: Three-dimensional In Vitro Biomimetic Model of Neuroblastoma using Collagen-based Scaffolds. The Authors section was updated. The Authors section was updated from: Ciara Gallagher*1,2,3 Catherine Murphy*1,2,3 Fergal J. Read More

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Validation of a Novel Double Control Quantitative Copy Number PCR Method to Quantify Off-Target Transgene Integration after CRISPR-Induced DNA Modification.

Methods Protoc 2022 May 25;5(3). Epub 2022 May 25.

Department of Nutritional Biochemistry, Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany.

In order to improve a recently established cell-based assay to assess the potency of botulinum neurotoxin, neuroblastoma-derived SiMa cells and induced pluripotent stem-cells (iPSC) were modified to incorporate the coding sequence of a reporter luciferase into a genetic safe harbor utilizing CRISPR/Cas9. A novel method, the double-control quantitative copy number PCR (dc-qcnPCR), was developed to detect off-target integrations of donor DNA. The donor DNA insertion success rate and targeted insertion success rate were analyzed in clones of each cell type. Read More

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Comparative Study on the Performance of Three Detection Methods for the Quantification of Pacific Ciguatoxins in French Polynesian Strains of .

Mar Drugs 2022 May 25;20(6). Epub 2022 May 25.

Institut Louis Malardé (ILM), Laboratory of Marine Biotoxins, UMR 241-EIO (IFREMER, ILM, IRD, Université de Polynésie Française), P.O. Box 30, Papeete 98713, French Polynesia.

and dinoflagellates produce a suite of secondary metabolites, including ciguatoxins (CTXs), which bioaccumulate and are further biotransformed in fish and marine invertebrates, causing ciguatera poisoning when consumed by humans. This study is the first to compare the performance of the fluorescent receptor binding assay (fRBA), neuroblastoma cell-based assay (CBA-N2a), and liquid chromatography tandem mass spectrometry (LC-MS/MS) for the quantitative estimation of CTX contents in 30 samples, obtained from four French Polynesian strains of . fRBA was applied to matrix for the first time, and several parameters of the fRBA protocol were refined. Read More

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Postchemotherapy gross residual tumor in non-high-risk neuroblastoma: Clinical significance and the role of adjuvant therapy.

Pediatr Blood Cancer 2022 Jun 23:e29840. Epub 2022 Jun 23.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Although survival rate among patients with non-high-risk neuroblastoma is excellent, a gross residual tumor (GRT) is often present at the end of treatment. However, reliable data do not exist on the relevance of a GRT for the risk of progression and the role of adjuvant therapy for patients with GRT.

Methods: A retrospective review of 131 patients with non-high-risk neuroblastoma who underwent chemotherapy was performed. Read More

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Dramatic response to targeted therapy in an aggressive olfactory neuroblastoma: illustrative case.

J Neurosurg Case Lessons 2022 Jun 13;3(24):CASE21663. Epub 2022 Jun 13.

Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma.

Background: Olfactory neuroblastomas are rare sinonasal tumors that arise from the olfactory epithelium. The authors presented a case of an olfactory neuroblastoma with extensive cranial invasion that demonstrated dramatic response to sorafenib, a tyrosine kinase inhibitor.

Observations: A 54-year-old man with history of prostate cancer and melanoma presented with left-sided proptosis and was found to have a 6. Read More

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Adrenal and Mesenteric Teratomas in Infants: Common Tumors in Uncommon Sites.

J Indian Assoc Pediatr Surg 2022 May-Jun;27(3):354-356. Epub 2022 May 12.

Department of Pediatric Surgery, NRS Medical College, Kolkata, West Bengal, India.

Teratomas are common tumors in children. The most common sites are gonads, however, several extragonadal sites are well known such as sacrococcygeal region, mediastinum, head and neck, stomach, and vagina. Occasionally, teratomas occur in unusual sites which pose diagnostic difficulties. Read More

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Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma.

Cell Rep 2022 Jun;39(12):111000

Department of Pharmaceutical Sciences, Drug Discovery Center, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

Prostaglandin E (PGE) promotes tumor cell proliferation, migration, and invasion, fostering an inflammation-enriched microenvironment that facilitates angiogenesis and immune evasion. However, the PGE receptor subtype (EP1-EP4) involved in neuroblastoma (NB) growth remains elusive. Herein, we show that the EP2 receptor highly correlates with NB aggressiveness and acts as a predominant Gα-coupled receptor mediating PGE-initiated cyclic AMP (cAMP) signaling in NB cells with high-risk factors, including 11q deletion and MYCN amplification. Read More

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Biomimicked large-area anisotropic grooves from Dracaena Sanderiana leaf enhances cellular alignment and subsequent differentiation.

Bioinspir Biomim 2022 Jun 21. Epub 2022 Jun 21.

Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, Mumbai, 400076, INDIA.

Cellular alignment is important for the proper functioning of different tissues such as muscles or blood vessel walls. Hence, in tissue engineering, sufficient effort has been made to control cellular orientation and alignment. It has been shown that micro-and nanoscale anisotropic topological features on cell culture substrates can control cellular orientation. Read More

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The histone deacetylase inhibitor OBP-801 has in vitro/in vivo anti-neuroblastoma activity.

Pediatr Int 2022 Jan;64(1):e15159

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto City, Kyoto, Japan.

Background: Patients with high-risk neuroblastoma have a poor prognosis; new therapeutic agents are therefore required. We investigated the antitumor effects of OBP-801, a novel histone deacetylase inhibitor, its underlying mechanism, and its potential as a therapeutic agent for patients with neuroblastoma.

Methods: The study included five human neuroblastoma cell lines: IMR32, GOTO, KP-N-RTBM, SK-N-AS, and SH-SY5Y. Read More

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January 2022

Asphericity of tumor [ I]mIBG uptake as a prognostic factor in high-risk neuroblastoma.

Pediatr Blood Cancer 2022 Jun 21:e29849. Epub 2022 Jun 21.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Background: In recent years, many research groups have attempted to identify a subgroup of "ultra-high risk" patients within the high-risk neuroblastoma (NB) category. The aim of our study was to evaluate the prognostic significance of parameters derived from pretherapeutic I-meta-iodobenzylguanidine ([ I]mIBG) integrated single photon emission computed tomography and computed tomography in high-risk patients with NB.

Methods: The established parameters metabolic tumor volume (MTV), maximal standardized uptake value (SUV ) and the novel parameter tumor asphericity as well as clinical (age, stage) and genetic factors (1p/11q deletions and MYCN amplification) were analyzed in this single-center retrospective study of high-risk patients with newly diagnosed NB. Read More

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MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment.

BMC Cancer 2022 Jun 17;22(1):669. Epub 2022 Jun 17.

Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.

Background: The bone marrow (BM) is the most common site of dissemination in patients with aggressive, metastatic neuroblastoma (NB). However, the molecular mechanisms underlying the aggressive behavior of NB cells in the BM niche are still greatly unknown. In the present study, we explored biological mechanisms that play a critical role in NB cell survival and progression in the BM and investigated potential therapeutic targets. Read More

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[Clinical characteristics and prognostic analyses of cervical neuroblastoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):711-717

Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To determine the characteristics of cervical neuroblastoma and the effect of resection extent on survival and outcomes. We performed a retrospective review of 32 children with cervical neuroblastoma treated at Beijing Children's Hospital between April 2013 and August 2020. Data were collected from the medical record. Read More

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Vanillin crosslinked chitosan films: The states of water and the effect of carriers on curcumin uptake.

Carbohydr Polym 2022 Sep 11;292:119725. Epub 2022 Jun 11.

Fundamental Chemistry Department, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil. Electronic address:

In this work, chitosan chains were crosslinked with different contents of vanillin (Van), characterized and loaded with curcumin (CUR), a hydrophobic drug. Sodium dodecyl sulfate (SDS), Tween 20® (T20) and β-cyclodextrin (βCD) were used as curcumin carriers. Films prepared with Van 20 % yielded gel content of 70 %, swelling degree of ~23 g/g, bound water and capillary water, as revealed by Time-Domain Nuclear Magnetic Resonance measurements. Read More

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September 2022

Nordentatin Inhibits Neuroblastoma Cell Proliferation and Migration through Regulation of GSK-3 Pathway.

Curr Issues Mol Biol 2022 Feb 24;44(3):1062-1074. Epub 2022 Feb 24.

Faculty of pharmaceutical sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.

Cancer is caused by abnormal cell changes leading to uncontrolled cell growth. The specific characteristics of cancer cells, including the loss of apoptotic control and the ability to migrate into and invade the surrounding tissue, result in cancer cell metastasis to other parts of the body. Therefore, the inhibition of the proliferation, migration, and invasion of cancer cells are the principal goals in the treatment of cancer. Read More

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February 2022

A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt( -CHOMe)(DMSO)(phen)] (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells.

Bioinorg Chem Appl 2022 10;2022:8932137. Epub 2022 Jun 10.

Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100 Lecce, Italy.

NMR-based metabolomics is a very effective tool to assess the tumor response to drugs by providing insights for their mode of action. Recently, a novel Pt(II) complex, [Pt(ƞ-CHOMe)(DMSO)(phen)] (phen =  1,10-phenanthroline), Pt-EtOMeSOphen, was synthesized and studied for its antitumor activity against eight human cancer cell lines. Pt-EtOMeSOphen showed higher cytotoxic effects than cisplatin in most of the cancer cell lines and in particular against the neuroblastoma cell line (SH-SY5Y). Read More

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