42,291 results match your criteria Neuroblastoma


CpG-coated Prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma.

Transl Oncol 2020 Jul 8;13(10):100823. Epub 2020 Jul 8.

The George Washington Cancer Center, The George Washington University, Washington, DC 20052, USA; The Institute for Biomedical Sciences, The George Washington University, Washington, DC 20037, USA; Department of Medicine, The George Washington University, Washington, DC 20037, USA. Electronic address:

High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a "nanoimmunotherapy," which combines photothermal therapy (PTT) using CpG oligodeoxynucleotide-coated Prussian blue nanoparticles (CpG-PBNPs) combined with anti-CTLA-4 (aCTLA-4) immunotherapy. Our in vitro studies demonstrate that in addition to causing ablative tumor cell death, our nanoimmunotherapy alters the surface levels of co-stimulatory, antigen-presenting, and co-inhibitory molecules on neuroblastoma tumor cells. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100823DOI Listing

Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression.

Cancer Res 2020 Jul 10. Epub 2020 Jul 10.

Experimental Therapeutics, Children's Cancer Institute Australia

The ability of the N-MYC transcription factor to drive cancer progression is well-demonstrated in neuroblastoma, the most common extracranial pediatric solid tumor, where MYCN-amplification heralds a poor prognosis with only 11% of patients surviving past 5 years. However, decades of attempts of direct inhibition of N-MYC or its paralogues has led to the conclusion that this protein is 'undruggable'. Therefore, targeting pathways upregulated by N-MYC signaling presents an alternative therapeutic approach. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-19-3914DOI Listing

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer.

Cancer Res 2020 Jul 10. Epub 2020 Jul 10.

Chemical Biology and Therapeutics, St. Jude Children's Research Hospital

Inhibition of members of the bromodomain and extra terminal (BET) family of proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1 and BD2) that are necessary for recognition of acetylated lysine residues in the N-terminal regions of histones. Chemical matter that targets BET (BETi) also interact via these domains. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-19-3934DOI Listing
July 2020
9.329 Impact Factor

Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes.

Acta Neuropathol Commun 2020 Jul 10;8(1):105. Epub 2020 Jul 10.

Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, A. Pawińskiego 5 Street, 02-106, Warsaw, Poland.

Four molecular types of rare central nervous system (CNS) tumors have been recently identified by gene methylation profiling: CNS Neuroblastoma with FOXR2 activation (CNS NB-FOXR2), CNS Ewing Sarcoma Family Tumor with CIC alteration (CNS EFT-CIC), CNS high grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1) and CNS high grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR). Although they are not represented in 2016 updated WHO classification of CNS tumors, their diagnostic recognition is important because of clinical consequences. We have introduced a diagnostic method based on transcription profiling of tumor specific signature genes from formalin-fixed, paraffin-embedded tumor blocks using NanoString nCounter Technology. Read More

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http://dx.doi.org/10.1186/s40478-020-00984-9DOI Listing

The Effects of Prebiotic Supplementation with OMNi-LOGiC FIBRE on Fecal Microbiome, Fecal Volatile Organic Compounds, and Gut Permeability in Murine Neuroblastoma-Induced Tumor-Associated Cachexia.

Nutrients 2020 Jul 8;12(7). Epub 2020 Jul 8.

Department of Paediatric and Adolescent Surgery, Medical University of Graz, 8036 Graz, Austria.

Malignant diseases can cause tumor-associated cachexia (TAC). Supplementation with prebiotic non-digestible carbohydrates exerts positive metabolic effects in experimental oncologic diseases. The aim of this project was to assess the effect of prebiotic supplementation with OMNi-LOGiC FIBRE on intestinal microbiome, bacterial metabolism, gut permeability, and inflammation in a murine model of neuroblastoma (NB)-associated TAC. Read More

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http://dx.doi.org/10.3390/nu12072029DOI Listing

Association of LINC00673 rs11655237 polymorphism with cancer susceptibility: A meta-analysis based on 23,478 subjects.

Genomics 2020 Jul 7. Epub 2020 Jul 7.

Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, PR China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110122, PR China. Electronic address:

Background: Some studies on the relationship between LINC00673 polymorphism and cancer susceptibility have been inconsistent. To perform a more comprehensively quantitative assessment of LINC00673 rs11655237 and risk of overall cancer, we operated this meta-analysis for the first time.

Methods: A comprehensive search was conducted to obtain relevant literature up to November 20, 2019. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.07.015DOI Listing

A Novel Standard for Systematic Reporting of Neuroblastoma Surgery: The International Neuroblastoma Surgical Report Form (INSRF): A Joint Initiative by the Pediatric Oncological Cooperative Groups SIOPEN*, COG**, and GPOH**.

Ann Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatric Surgery, Université de Paris, Hôpital Necker Enfants-Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objective: To create the first structured surgical report form for NBL with international consensus, to permit standardized documentation of all NBL-related surgical procedures and their outcomes.

Summary Of Background Data: NBL, the most common extracranial solid malignant tumor in children, covers a wide spectrum of tumors with significant differences in anatomical localization, organ or vessel involvement, and tumor biology. Complete surgical resection of the primary tumor is an important part of NBL treatment, but maybe hazardous, prone to complications and its role in high-risk disease remains debated. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003947DOI Listing

PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP.

Aging (Albany NY) 2020 Jul 10;12. Epub 2020 Jul 10.

Department of Anesthesiology, Huai'an Maternity and Child Clinical College of Xuzhou Medical University, Huai'an, China.

The neurotoxin MPP (1-methyl-4-phenylpyridinium ion) disrupts mitochondrial function leading to oxidative stress and neuronal death. Here we examine whether activation of the Keap1-Nrf2 cascade can protect SH-SY5Y neuroblastoma cells from MPP-induced cytotoxicity. Treatment of SH-SY5Y cells with CBR-470-1, an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1), leads to methylglyoxal modification of Keap1, Keap1-Nrf2 disassociation, and increased expression of Nrf2 responsive genes. Read More

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http://dx.doi.org/10.18632/aging.103443DOI Listing

Wafer-Scale Fabrication of Conducting Polymer Hydrogels for Microelectrodes and Flexible Bioelectronics.

Adv Biosyst 2019 Aug 15;3(8):e1900072. Epub 2019 Jul 15.

Department of Microsystems Engineering, IMTEK, University of Freiburg, 79110, Freiburg, Germany.

Future-oriented directions in neural interface technologies point towards the development of multimodal devices that combine different functionalities such as neural stimulation, neurotransmitter sensing, and drug release within one platform. Conducting polymer hydrogels (CPHs) are suggested as materials for the coating of standard metal electrodes to add functionalities such as local delivery of therapeutic drugs. However, to make such coatings truly useful for multimodal devices, it is necessary to develop process technologies that allow the micropatterning of CPHs onto selected electrode sites. Read More

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http://dx.doi.org/10.1002/adbi.201900072DOI Listing

neurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells.

J Recept Signal Transduct Res 2020 Jul 9:1-13. Epub 2020 Jul 9.

Neuroscience Research Center, Suleyman Demirel University, Isparta, Turkey.

Background: The neurotoxin A (BTX) is a polypeptide produced by the bacterium . In addition to the therapeutic actions of BTX against pain and neuromuscular disorders, it is acted as anticancerogenic effect through excessive mitochondria reactive oxygen species (ROS) production, apoptosis, and caspase activations. The TRPM2 cation channel is activated by ROS and ADP-ribose and it is inhibited by 2-aminoethyl diphenylborinate (2-APB) and N-(p-amylcinnamoyl) anthranilic acid (ACA). Read More

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http://dx.doi.org/10.1080/10799893.2020.1781174DOI Listing

A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors.

MAbs 2020 Jan-Dec;12(1):1773751

Department of Oncology, St. Jude Children's Research Hospital , Memphis, TN, USA.

Hu14.18K322A is a humanized anti-GD2 monoclonal antibody with a single point mutation that reduces complement-mediated cytotoxicity, with a maximum tolerated dose (MTD) of 60 mg/m daily for 4 days in children with recurrent/refractory neuroblastoma. We report additional results of a Phase 1 trial to determine the MTD and safety profile of hu14. Read More

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http://dx.doi.org/10.1080/19420862.2020.1773751DOI Listing

Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake.

EJNMMI Res 2020 Jul 8;10(1):78. Epub 2020 Jul 8.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Background: The therapeutic use of [I]meta-iodobenzylguanidine ([I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia. While MIBG accumulates in neuroblastoma cells via selective uptake by the norepinephrine transporter (NET), the serotonin transporter (SERT) is responsible for cellular uptake of MIBG in platelets. In this study, we have investigated whether pharmacological intervention with selective serotonin reuptake inhibitors (SSRIs) may prevent radiotoxic MIBG uptake in platelets without affecting neuroblastoma tumor uptake. Read More

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http://dx.doi.org/10.1186/s13550-020-00662-wDOI Listing

PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells.

Lab Invest 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is 7.6 kDa peptide originally found in Purkinje cells. PCP4/PEP19 is a differentiation maker of Purkinje cells, where it functions as an antiapoptotic factor. Read More

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http://dx.doi.org/10.1038/s41374-020-0462-zDOI Listing

Choroidal metastases as a presenting manifestation of neuroblastoma.

BMJ Case Rep 2020 07 7;13(7). Epub 2020 Jul 7.

Department of Retina-Vitreous services, Aravind Eye Hospital, Madurai, India.

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http://dx.doi.org/10.1136/bcr-2020-235730DOI Listing

Quantitative characterization of phenotypical markers after differentiation of SH-SY5Y cells.

CNS Neurol Disord Drug Targets 2020 Jul 8. Epub 2020 Jul 8.

Division of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Bern, 3001 Bern. Switzerland.

Background: The human neuroblastoma cell line, SH-SY5Y has been widely used in neuroscience research, especially in studies related to Parkinson's disease. However, differences between clones have been demonstrated, highlighting the importance to characterize the properties of this cell line carefully.

Objective: The aim of this study was to characterize the phenotype of undifferentiated and differentiated SH-SY5Y cells using various differentiation protocols. Read More

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http://dx.doi.org/10.2174/1871527319666200708132716DOI Listing

Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study.

J Clin Oncol 2020 Jul 8:JCO1903117. Epub 2020 Jul 8.

St Anna Children's Hospital and Children's Cancer Research Institute, Department of Paediatrics, Medical University of Vienna, Vienna, Austria.

Purpose: To evaluate the impact of surgeon-assessed extent of primary tumor resection on local progression and survival in patients in the International Society of Pediatric Oncology Europe Neuroblastoma Group High-Risk Neuroblastoma 1 trial.

Patients And Methods: Patients recruited between 2002 and 2015 with stage 4 disease > 1 year or stage 4/4S with amplification < 1 year who had completed induction without progression, achieved response criteria for high-dose therapy (HDT), and had no resection before induction were included. Data were collected on the extent of primary tumor excision, severe operative complications, and outcome. Read More

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http://dx.doi.org/10.1200/JCO.19.03117DOI Listing

Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression.

Mol Ther Oncolytics 2020 Sep 1;18:14-23. Epub 2020 Jun 1.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Neuroblastoma (NB) is a primary malignant tumor of the peripheral sympathetic nervous system. High-risk NB is characterized by amplification and human telomerase reverse transcriptase () rearrangement, contributing to hTERT activation and a poor outcome. For targeting hTERT-activated tumors, we developed two oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in which the hTERT promoter drives expression of the viral gene for tumor-specific virus replication. Read More

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http://dx.doi.org/10.1016/j.omto.2020.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321810PMC
September 2020

A sellar neuroblastoma showing rapid growth and causing syndrome of inappropriate secretion of antidiuretic hormone: A case report.

Surg Neurol Int 2020 27;11:165. Epub 2020 Jun 27.

Departments of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-7 Sakuragaoka, Kagoshima.

Background: Sellar neuroblastoma is a very rare entity. We report a rare case of arginine vasopressin (AVP)- producing sellar neuroblastoma presumed to have originated from the lower part of sellar turcica, which grew very rapidly.

Case Description: A 33-year-old woman was found to have a sellar lesion with a diameter of 18 mm invading into the bilateral cavernous sinus on magnetic resonance imaging (MRI) performed for dizziness. Read More

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http://dx.doi.org/10.25259/SNI_97_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332709PMC

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

Life Sci Alliance 2020 Aug 7;3(8). Epub 2020 Jul 7.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. We present the characterisation of an N-cyano pyrrolidine compound, FT3967385, with high selectivity for USP30. We demonstrate that ubiquitylation of TOM20, a component of the outer mitochondrial membrane import machinery, represents a robust biomarker for both USP30 loss and inhibition. Read More

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http://dx.doi.org/10.26508/lsa.202000768DOI Listing

In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi).

Int J Mol Sci 2020 Jul 3;21(13). Epub 2020 Jul 3.

Institute of Toxicology, Medical Faculty, Heinrich Heine University Duesseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

Histone deacetylase inhibitors (HDACi) are already approved for the therapy of leukemias. Since they are also emerging candidate compounds for the treatment of non-malignant diseases, HDACi with a wide therapeutic window and low hazard potential are desirable. Here, we investigated a panel of 12 novel hydroxamic acid- and benzamide-type HDACi employing non-malignant V79 hamster cells as toxicology guideline-conform in vitro model. Read More

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http://dx.doi.org/10.3390/ijms21134747DOI Listing

A comparison of phase I dose-finding designs in clinical trials with monotonicity assumption violation.

Clin Trials 2020 Jul 7:1740774520932130. Epub 2020 Jul 7.

Department of Mathematics and Statistics, Lancaster University, Lancaster, UK.

Background/aims: In oncology, new combined treatments make it difficult to order dose levels according to monotonically increasing toxicity. New flexible dose-finding designs that take into account uncertainty in dose levels ordering were compared with classical designs through simulations in the setting of the monotonicity assumption violation. We give recommendations for the choice of dose-finding design. Read More

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http://dx.doi.org/10.1177/1740774520932130DOI Listing

Protective Effect of Fucoidan against MPP-Induced SH-SY5Y Cells Apoptosis by Affecting the PI3K/Akt Pathway.

Mar Drugs 2020 Jun 25;18(6). Epub 2020 Jun 25.

Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.

The main pathologic changes of the Parkinson's disease (PD) is dopaminergic (DA) neurons lost. Apoptosis was one of the important reasons involved in the DA lost. Our previous study found a fucoidan fraction sulfated heterosaccharide (UF) had neuroprotective activity. Read More

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http://dx.doi.org/10.3390/md18060333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344518PMC

Plant-Derived Natural Biomolecule Picein Attenuates Menadione Induced Oxidative Stress on Neuroblastoma Cell Mitochondria.

Antioxidants (Basel) 2020 Jun 25;9(6). Epub 2020 Jun 25.

Department of Applied Physics, Aalto University, 00076 Espoo, Finland.

Several bioactive compounds are in use for the treatment of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. Historically, willow ( sp.) bark has been an important source of salisylic acid and other natural compounds with anti-inflammatory, antipyretic and analgesic properties. Read More

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http://dx.doi.org/10.3390/antiox9060552DOI Listing

Amino Acid at Position 166 of NS2A in Japanese Encephalitis Virus (JEV) is Associated with In Vitro Growth Characteristics of JEV.

Viruses 2020 Jun 30;12(7). Epub 2020 Jun 30.

Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan.

We previously showed that the growth ability of the Japanese encephalitis virus (JEV) genotype V (GV) strain Muar is clearly lower than that of the genotype I (GI) JEV strain Mie/41/2002 in murine neuroblastoma cells. Here, we sought to identify the region in GV JEV that is involved in its low growth potential in cultured cells. An intertypic virus containing the NS1-3 region of Muar in the Mie/41/2002 backbone (NS1-3) exhibited a markedly diminished growth ability in murine neuroblastoma cells. Read More

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http://dx.doi.org/10.3390/v12070709DOI Listing

Expression Patterns of Immune Genes Reveal Heterogeneous Subtypes of High-Risk Neuroblastoma.

Cancers (Basel) 2020 Jun 30;12(7). Epub 2020 Jun 30.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

High risk neuroblastoma (HR-NB) remains difficult to treat, and its overall survival (OS) is still below 50%. Although HR-NB is a heterogeneous disease, HR-NB patients are currently treated in a similar fashion. Through unsupervised biclustering, we further stratified HR-NB patients into two reproducible and clinically distinct subtypes, including an ultra-high risk neuroblastoma (UHR-NB) and high risk neuroblastoma (HR-NB). Read More

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http://dx.doi.org/10.3390/cancers12071739DOI Listing

Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Department of Precision Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Via L. De Crecchio 7, 80138 Naples, Italy.

Hydroxytyrosol (HT), one of the main phenolic components of olive oil, has attracted considerable interest for its biological properties, including a remarkable antioxidant and anti-inflammatory power and, recently, for its ability to interfere with the amyloid aggregation underlying several human diseases. We report here a broad biophysical approach and cell biology techniques that allowed us to characterize the molecular mechanisms by which HT affects insulin amyloid aggregation and the related cytotoxicity. Our data show that HT is able to fully inhibit insulin amyloid aggregation and this property seems to be ascribed to the stabilization of the insulin monomeric state. Read More

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http://dx.doi.org/10.3390/ijms21134636DOI Listing

Dermatan sulfate obtained from the Phallusia nigra marine organism is responsible for antioxidant activity and neuroprotection in the neuroblastoma-2A cell lineage.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

Laboratório Integrado de Biociências Translacionais, Instituto de Biodiversidade e Sustentabilidade, NUPEM, Av. São José do Barreto, 764, Universidade Federal do Rio de Janeiro, Macaé 27910-970, RJ, Brazil; Pós-Graduação em Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, UENF, Av. Alberto Lamego, 2000, Campos dos Goytacazes 28013-602, RJ, Brazil. Electronic address:

Neurodegenerative diseases are characterized by progressive loss of neurons in the central nervous system (CNS). Several molecules play a role in mammalian CNS regeneration, including glycosaminoglycans (GAGs). GAGs are found in abundance in many marine invertebrates, such as ascidians that belong to the phylum Chordata, which show a high CNS regeneration capacity even in adulthood. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.285DOI Listing

Comparison of Open and Endoscopic Approaches in the Resection of Esthesioneuroblastoma.

Ann Otol Rhinol Laryngol 2020 Jul 4:3489420939582. Epub 2020 Jul 4.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.

Background: Olfactory neuroblastoma, or esthesioneuroblastoma (ENB), is an uncommon sinonasal malignancy arising from olfactory neuroepithelium that is optimally treated with surgical resection. The objective of this study is to determine preoperative predictors of undergoing open versus endoscopic approach for ENB and to investigate significant postoperative survival outcomes between the two surgical approaches.

Methods: The National Cancer Database (NCDB) was queried for cases of ENB histology that were treated surgically from 2010 to 2015. Read More

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http://dx.doi.org/10.1177/0003489420939582DOI Listing

Substrate stiffness effects on SH-SY5Y: The dichotomy of morphology and neuronal behavior.

J Biomed Mater Res B Appl Biomater 2020 Jul 5. Epub 2020 Jul 5.

Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.

Like many other cell types, neuroblastoma cells are also known to respond to mechanical cues in their microenvironment in vitro. They were shown to have mechanotransduction pathways, which result in enhanced neuronal morphology on stiff substrates. However, in previous studies, the differentiation process was monitored only by morphological parameters. Read More

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http://dx.doi.org/10.1002/jbm.b.34684DOI Listing

Anti-aging Klotho Protects SH-SY5Y Cells Against Amyloid β1-42 Neurotoxicity: Involvement of Wnt1/pCREB/Nrf2/HO-1 Signaling.

J Mol Neurosci 2020 Jul 5. Epub 2020 Jul 5.

Neurophysiology Research Center, Shahed University, Tehran, Iran.

Alzheimer's disease (AD) is considered a prevalent neurological disorder with a neurodegenerative nature in elderly people. Oxidative stress and neuroinflammation due to amyloid β (Aβ) peptides are strongly involved in AD pathogenesis. Klotho is an anti-aging protein with multiple protective effects that its deficiency is involved in development of age-related disorders. Read More

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http://dx.doi.org/10.1007/s12031-020-01621-9DOI Listing

An elongated tract of polyQ in the carboxyl‑terminus of human α1A calcium channel induces cell apoptosis by nuclear translocation.

Oncol Rep 2020 Jul 22;44(1):156-164. Epub 2020 Apr 22.

Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

An aberrant elongated tract of glutamine residues (polyQ) in proteins induces multiple diseases treated in the clinic. In our previous study of progressive myoclonic epilepsy (PME), using whole‑exome sequencing, a mutant Cav2.1 protein with an aberrant elongated polyQ tract was identified in PME patients. Read More

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http://dx.doi.org/10.3892/or.2020.7592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251683PMC

Schizophrenia‑associated microRNA‑148b‑3p regulates COMT and PRSS16 expression by targeting the ZNF804A gene in human neuroblastoma cells.

Mol Med Rep 2020 Aug 15;22(2):1429-1439. Epub 2020 Jun 15.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

Zinc finger protein 804A (ZNF804A) has been identified by genome‑wide association studies as a robust risk gene in schizophrenia, but how ZNF804A contributes to schizophrenia and its upstream regulation remains unknown. Previous studies have indicated that microRNAs (miRs) are key factors that regulate the expression levels of their target genes. The present study revealed significantly increased expression of miR‑148b‑3p in the peripheral blood of patients with first‑onset schizophrenia compared with healthy controls, and bioinformatics analysis predicted that the ZNF804A gene is a target of miR‑148b‑3p. Read More

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http://dx.doi.org/10.3892/mmr.2020.11230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339789PMC

Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy.

Front Pharmacol 2020 17;11:897. Epub 2020 Jun 17.

Clinical and Experimental Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery is the standard of care for patients with Locally Advanced Rectal Cancer (LARC). Current selection for nCRT is based on clinical criteria regardless of any molecular marker. Pharmacogenomics may be a useful strategy to personalize and optimize nCRT in LARC. Read More

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http://dx.doi.org/10.3389/fphar.2020.00897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311751PMC

Nutraceutical profiling of surimi gel containing β-glucan stabilized virgin coconut oil with and without antioxidants after simulated gastro-intestinal digestion.

J Food Sci Technol 2020 Aug 19;57(8):3132-3141. Epub 2020 Mar 19.

Department of Food Science and Technology, University of Kashmir, Srinagar, 190006 India.

Surimi gels containing β-glucan stabilized virgin coconut oil (VCO) were subjected to simulated gastrointestinal digestion and the resulting digest was analyzed for nutraceutical properties. β-glucan stabilized VCO nanoemulsion (βG-V-N) remarkably improved antioxidant activities of the surimi digest. When epigallocatechin gallate (EGCG) was added in nanoemulsion, the surimi digest showed the highest antioxidant activities. Read More

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http://dx.doi.org/10.1007/s13197-020-04347-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316897PMC

Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells.

Exp Neurobiol 2020 Jun;29(3):207-218

Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.

The formation of Lewy bodies (LBs), intracellular filamentous inclusions, is one of the hallmarks of Parkinson's disease (PD). α-Synuclein is the main component of LBs and its abnormal accumulation contributes to the pathogenesis of PD. Direct phosphorylation of α-synuclein at multiple Ser/Tyr residues is known to induce its aggregation, consequently promoting LB formation. Read More

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http://dx.doi.org/10.5607/en20014DOI Listing

GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative Activity in human neuroblastoma cells.

Free Radic Res 2020 Jul 6:1-39. Epub 2020 Jul 6.

Department of Biological Sciences, University of Ulsan, Ulsan, 44610, Republic of Korea.

The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining cellular homeostasis during environmental stress. Furthermore, oxidative stress is a critical cause for the progression of neurodegenerative diseases. Read More

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http://dx.doi.org/10.1080/10715762.2020.1791843DOI Listing

Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting.

FASEB J 2020 Jul 5. Epub 2020 Jul 5.

Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

The majority of anti-cancer therapies target the proliferating tumor cells, while the tumor stroma, principally unaffected, survives, and provide a niche for surviving tumor cells. Combining tumor cell and stroma-targeting therapies thus have a potential to improve patient outcome. The neuroblastoma stroma contains cancer-associated fibroblasts expressing microsomal prostaglandin E synthase-1 (mPGES-1). Read More

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http://dx.doi.org/10.1096/fj.202000684RDOI Listing

NBPF1 independently determine the risk stratification and prognosis of patients with neuroblastoma.

Genomics 2020 Jun 30. Epub 2020 Jun 30.

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address:

Neuroblastoma is the most frequent extracranial malignant solid tumor in children, and the 5 year OS of high risk neuroblastoma patients was less than 15%. This study aimed to identify biomarkers for risk stratification and prognosis prediction in neuroblastoma.149 low risk samples, 108 intermediate risk samples and 619 high risk samples were included in our study, and NBPF1 gene was found to be significantly correlated with risk levels and OS. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.06.038DOI Listing

Association between METTL3 gene polymorphisms and neuroblastoma susceptibility: A nine-centre case-control study.

J Cell Mol Med 2020 Jul 2. Epub 2020 Jul 2.

Department of General Surgery, Xi'an Children's Hospital, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, China.

Neuroblastoma ranks as the most commonly seen and deadly solid tumour in infancy. The aberrant activity of m A-RNA methyltransferase METTL3 is involved in human cancers. Therefore, functional genetic variants in the METTL3 gene may contribute to neuroblastoma risk. Read More

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http://dx.doi.org/10.1111/jcmm.15576DOI Listing

The role of GLP-1/GIP receptor agonists in Alzheimer's disease.

Adv Clin Exp Med 2020 Jun;29(6):661-668

Department of Geriatrics, Second Affiliated Hospital of the Harbin Medical University, China.

Background: New glucagon-like peptide-1 (GLP-1) analogues developed in recent years have a long half-life and offer further prospects for clinical application. At present, the neuroprotection of GLP-1 analogues in Alzheimer's disease (AD) has just begun to be explored.

Objectives: To investigate how glucagon-like peptide-1 (liraglutide) plays a protective role in AD by regulating tau activation and BACE1 expression. Read More

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http://dx.doi.org/10.17219/acem/121007DOI Listing

LncRNA SNHG4 promotes neuroblastoma proliferation, migration, and invasion by sponging miR-377-3p.

Neoplasma 2020 Jul 2. Epub 2020 Jul 2.

Department of Pediatrics, Jingzhou Central Hospital of Hubei Province, Jingzhou, China.

Long non-coding RNAs (lncRNAs) have been demonstrated to act as essential regulators in the growth and progression of neuroblastoma. In the present research, the high expression of lncRNA small nucleolar RNA host gene 4 (SNHG4) in neuroblastoma was tested via quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and then the function of SNHG4 was explored and verified by CCK-8 assay, EdU assay, cell cycle assay, cell apoptosis test, wound healing test and invasion test in neuroblastoma cell lines. It was discovered that lncRNA SNHG4 exhibited high expression in neuroblastoma tissues and cell lines, and the expression of SNHG4 was associated with the survival of neuroblastoma patients. Read More

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http://dx.doi.org/10.4149/neo_2020_191023N1081DOI Listing

Disparities in the use of antineoplastic immunotherapy in pediatric malignant adrenal tumors.

Pediatr Blood Cancer 2020 Jul 2:e28522. Epub 2020 Jul 2.

Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida.

Dinutuximab is a costly life-prolonging immunotherapy for high-risk neuroblastoma. We used a large pediatric inpatient database to analyze the use of antineoplastic immunotherapy in patients with malignant adrenal tumors 1 year after Food and Drug Administration approval of dinutuximab for high-risk neuroblastoma. On multivariate modeling, children of Black race (odds ratio [OR] 0. Read More

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http://dx.doi.org/10.1002/pbc.28522DOI Listing

Upconversion nanoparticles as intracellular pH messengers.

Anal Bioanal Chem 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Dr., Cambridge, CB3 0AS, UK.

Upconversion nanoparticles (UCNPs) should be particularly well suited for measurement inside cells because they can be imaged down to submicrometer dimensions in near real time using fluorescence microscopy, and they overcome problems, such as photobleaching, autofluorescence, and deep tissue penetration, that are commonly encountered in cellular imaging applications. In this study, the performance of an UCNP modified with a pH-sensitive dye (pHAb) is studied. The dye (emission wavelength 580 nm) was attached in a polyethylene imine (PEI) coating on the UCNP and excited via the 540-nm UCNP emission under 980-nm excitation. Read More

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http://dx.doi.org/10.1007/s00216-020-02768-5DOI Listing

Global analysis of protein degradation in prion infected cells.

Sci Rep 2020 Jul 1;10(1):10800. Epub 2020 Jul 1.

Department of Biology, University of Rochester, New York, 14627, USA.

Prion diseases are rare, neurological disorders caused by the misfolding of the cellular prion protein (PrP) into cytotoxic fibrils (PrP). Intracellular PrP aggregates primarily accumulate within late endosomes and lysosomes, organelles that participate in the degradation and turnover of a large subset of the proteome. Thus, intracellular accumulation of PrP aggregates has the potential to globally influence protein degradation kinetics within an infected cell. Read More

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http://dx.doi.org/10.1038/s41598-020-67505-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329860PMC

Late mortality in survivors of childhood cancer in Hungary.

Sci Rep 2020 Jul 1;10(1):10761. Epub 2020 Jul 1.

2nd Department of Pediatrics, Semmelweis University, 7-9. Tűzoltó Str., 1094, Budapest, Hungary.

The Hungarian Pediatric Oncology Network provides centralized treatment and population-based registration for cases of childhood cancer since 1973. We collected and analized data on late mortality, secondary malignancies and cardiac diseases in survivors (> 5 years) of childhood cancer to evaluate long-term risks. We extracted all solid tumour cases (3,650 followed up for 5-39. Read More

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http://dx.doi.org/10.1038/s41598-020-67444-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329824PMC

Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation.

Sci Rep 2020 Jul 1;10(1):10748. Epub 2020 Jul 1.

Department of Biological Sciences, Columbia University, New York City, NY, 10027, USA.

The identification of targeted agents with high therapeutic index is a major challenge for cancer drug discovery. We found that screening chemical libraries across neuroblastoma (NBL) tumor subtypes for selectively-lethal compounds revealed metabolic dependencies that defined each subtype. Bioactive compounds were screened across cell models of mesenchymal (MESN) and MYCN-amplified (MYCNA) NBL subtypes, which revealed the mevalonate and folate biosynthetic pathways as MESN-selective dependencies. Read More

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http://dx.doi.org/10.1038/s41598-020-67310-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329873PMC

Low Levels of Brain-Derived Neurotrophic Factor Trigger Self-aggregated Amyloid β-Induced Neuronal Cell Death in an Alzheimer's Cell Model.

Biol Pharm Bull 2020 ;43(7):1073-1080

Department of Genomic Medicinal Science, Research Institute for Science and Technology, Organization for Research Advancement, Tokyo University of Science.

Alzheimer's disease (AD) is pathologically characterized by accumulation of amyloid β (Aβ) and hyperphosphorylated tau, and thereby induction of neuronal cell death. The Aβ-induced neuronal cell death has been shown to occur by several modes, such as apoptosis, necrosis, and necroptosis. Interestingly, in AD patients, the brain and serum levels of brain-derived neurotrophic factor (BDNF) have been reported to be significantly decreased. Read More

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http://dx.doi.org/10.1248/bpb.b20-00082DOI Listing
January 2020

Reduced-dose craniospinal irradiation for central nervous system relapsed neuroblastoma.

Pediatr Blood Cancer 2020 Jul 1:e28364. Epub 2020 Jul 1.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

Purpose: In patients with high-risk neuroblastoma, there is an increased recognition of relapse in the central nervous system (CNS). Craniospinal irradiation (CSI) has been an effective treatment but carries significant long-term complications. It is unclear whether reducing the CSI dose from 21 to 18 Gy can achieve similar CNS tumor control. Read More

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http://dx.doi.org/10.1002/pbc.28364DOI Listing

ERK Regulates NeuroD1-mediated Neurite Outgrowth via Proteasomal Degradation.

Exp Neurobiol 2020 Jun;29(3):189-206

Department of Anatomy, Ajou University School of Medicine, Suwon 16499, Korea.

Neurogenic differentiation 1 (NeuroD1) is a class B basic helix-loop-helix (bHLH) transcription factor and regulates differentiation and survival of neuronal and endocrine cells by means of several protein kinases, including extracellular signal-regulated kinase (ERK). However, the effect of phosphorylation on the functions of NeuroD1 by ERK has sparked controversy based on context-dependent differences across diverse species and cell types. Here, we evidenced that ERK-dependent phosphorylation controlled the stability of NeuroD1 and consequently, regulated proneural activity in neuronal cells. Read More

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http://dx.doi.org/10.5607/en20021DOI Listing

Dendrimer Nanodevices and Gallic Acid as Novel Strategies to Fight Chemoresistance in Neuroblastoma Cells.

Nanomaterials (Basel) 2020 Jun 26;10(6). Epub 2020 Jun 26.

Department of Experimental Medicine-DIMES, University of Genoa, Via Alberti L.B., 16132 Genoa, Italy.

Human neuroblastoma (NB), a pediatric tumor inclined to relapse, after an initial response to therapy, usually develops resistance. Since several chemotherapeutics exert anticancer effect by increasing reactive oxygen species (ROS), NB cells overproduce antioxidant compounds becoming drugs-resistant. A strategy to sensitize NB cells to chemotherapy involves reducing their antioxidant defenses and inducing ROS overproduction. Read More

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http://dx.doi.org/10.3390/nano10061243DOI Listing