40,490 results match your criteria Neuroblastoma


Hesperidin-CAMKIV interaction and its impact on cell proliferation and apoptosis in the human hepatic carcinoma and neuroblastoma cells.

J Cell Biochem 2019 Apr 25. Epub 2019 Apr 25.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.

Calcium/calmodulin-dependent protein kinase IV (CAMKIV) is a key regulatory molecule of cell signaling, and thereby controls its growth and proliferation, including expression of certain genes. The overexpression of CAMKIV is directly associated with the development of different types of cancers. Hesperidin is abundantly found in citrus fruits and exhibits wide range of pharmacological activities including anti-inflammatory, antibacterial and anticancerous effects. Read More

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http://dx.doi.org/10.1002/jcb.28774DOI Listing

Genetic Profile and Clinical Implications of Hepatoblastoma and Neuroblastoma Coexistence in a Child.

Front Oncol 2019 4;9:230. Epub 2019 Apr 4.

Department of Oncology and Hematology, University Children's Hospital, Krakow, Poland.

The aim of the following case report is to provide a description of the coexistence of two independent tumors in a child. A 9-month-old male was referred to Department of Pediatric Oncology and Hematology with hepatic tumor present on ultrasound imaging and symptoms of enlarged abdominal circumference. Physical examination revealed a palpable epigastric mass and the imaging techniques showed a tumor of the left hepatic lobe measuring 11 × 6. Read More

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http://dx.doi.org/10.3389/fonc.2019.00230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458242PMC

Radiological staging in neuroblastoma: computed tomography or magnetic resonance imaging?

Pol J Radiol 2019 18;84:e46-e53. Epub 2019 Jan 18.

Dokuz Eylul University School of Medicine, Department of Paediatric Oncology, Izmir, Turkey.

Purpose: To compare the effectiveness of computed tomography (CT) and magnetic resonance imaging (MRI) in the staging of neuroblastomas according to the International Neuroblastoma Risk Group Staging System (INRGSS).

Material And Methods: In this single-centre retrospective study we identified a total of 20 patients under the age of 18 years, who were admitted to our hospital with neuroblastoma between January 2005 and May 2018, and who had both CT and MRI examination. The INRGSS stages of tumours were evaluated by CT scan and MRI. Read More

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http://dx.doi.org/10.5114/pjr.2019.82736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479053PMC
January 2019

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.

In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. Read More

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http://dx.doi.org/10.1002/ijc.32361DOI Listing

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

PLoS One 2019 24;14(4):e0215905. Epub 2019 Apr 24.

Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America.

The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines. HERG channels are also expressed in a variety of cancer cells and control cell proliferation and apoptosis. Hypoxia, a common feature of tumors, alters gating properties of hERG currents in SH-SY5Y neuroblastoma cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215905PLOS
April 2019
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Growth-promoting effects of low-level butyl benzyl phthalate exposure on human neuroblastoma SH-SY5Y cells.

J Appl Toxicol 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Toxicology, MOE Key Laboratory of Environmental and Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.

The purpose of present study was to investigate the impact of butyl benzyl phthalate (BBP) on SH-SY5Y neuroblastoma cells in vitro. The cell counting kit-8 was used to measure cell proliferation and flow cytometry was utilized to study cell cycle phases and apoptosis. Western blotting and quantitative real-time polymerase chain reaction were used to detect levels of aromatase, estrogen receptors (ERs) and some apoptosis and cell cycle-related genes. Read More

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http://dx.doi.org/10.1002/jat.3803DOI Listing

Anti-GD2 antibody-containing immunotherapy postconsolidation therapy for people with high-risk neuroblastoma treated with autologous haematopoietic stem cell transplantation.

Cochrane Database Syst Rev 2019 Apr 24;4:CD012442. Epub 2019 Apr 24.

Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Kerpener Str. 62, Cologne, Germany, 50937.

Background: Neuroblastoma is a rare malignant disease that primarily affects children. The tumours mainly develop in the adrenal medullary tissue, and an abdominal mass is the most common presentation. High-risk disease is characterised by metastasis and other primary tumour characteristics resulting in increased risk for an adverse outcome. Read More

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http://dx.doi.org/10.1002/14651858.CD012442.pub2DOI Listing

Carnosic Acid Pretreatment Attenuates Mitochondrial Dysfunction in SH-SY5Y Cells in an Experimental Model of Glutamate-Induced Excitotoxicity.

Neurotox Res 2019 Apr 23. Epub 2019 Apr 23.

Grupo de Estudos em Neuroquímica e Neurobiologia de Moléculas Bioativas, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Cuiaba, MT, 78060-900, Brazil.

Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases. Read More

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http://dx.doi.org/10.1007/s12640-019-00044-8DOI Listing

Positron Emission Tomography Detects In Vivo Expression of Disialoganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma.

Cancer Res 2019 Apr 23. Epub 2019 Apr 23.

Diagnostic Imaging, St. Jude Children's Research Hospital

The cell membrane glycolipid GD2 is expressed by multiple solid tumors, including 88% of osteosarcomas and 98% of neuroblastomas. However, osteosarcomas are highly heterogeneous with many tumors exhibiting GD2 expression on <50% of the individual cells while some tumors are essentially GD2-negative. Anti-GD2 immunotherapy is the current standard of care for high-risk neuroblastoma, but its application to recurrent osteosarcomas, for which no effective therapies exist, has been extremely limited. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3340DOI Listing

An Attempt to Characterize the Ciguatoxin Profile in Causing Ciguatera Fish Poisoning in Macaronesia.

Toxins (Basel) 2019 Apr 13;11(4). Epub 2019 Apr 13.

University of Vigo, Department of Analytical and Food Chemistry, Campus Universitario de Vigo, 36310 Vigo, Spain.

Ciguatera Fish Poisoning is a worldwide concern caused by the consumption of fish contaminated with ciguatoxins not only in endemic regions in the Pacific Ocean or the Caribbean Sea but also in emerging areas of Macaronesia on the eastern Atlantic. The recent emergence of these toxins in other coastal areas worldwide, prompted the need for the characterization of the risk in these areas. This Ciguatera Fish Poisoning risk has been recently identified as a potential threat in subtropical areas of the Atlantic coast and scientific efforts are being focused in the identification and confirmation of the toxins involved in this potential risk. Read More

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https://www.mdpi.com/2072-6651/11/4/221
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http://dx.doi.org/10.3390/toxins11040221DOI Listing
April 2019
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Treatment of human neuroblastoma cell line SH-SY5Y with HSP27 siRNA tagged-exosomes decreased differentiation rate into mature neurons.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Heat shock proteins (HSPs) participate in the regulation of different cell activities in response to stimuli. By applying different strategies, the modulation of heat shock proteins is at the center of attention. Conventional delivery approaches are not fully encouraged due to cytotoxicity and immunogenicity issues. Read More

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http://dx.doi.org/10.1002/jcp.28704DOI Listing
April 2019
3.839 Impact Factor

Engineering the TGFβ receptor to Enhance the Therapeutic Potential of Natural Killer Cells as an Immunotherapy for Neuroblastoma.

Clin Cancer Res 2019 Apr 22. Epub 2019 Apr 22.

CRI, Children's National Health System

Purpose: The ability of natural killer (NK) cells to lyse allogeneic targets, without the need for explicit matching or priming, makes them an attractive platform for cell-based immunotherapy. Umbilical cord blood is a practical source for generating banks of such third party NK cells for "off the shelf" cell therapy applications. NK cells are highly cytolytic, and their potent antitumor effects can be rapidly triggered by a lack of HLA expression on interacting target cells, as is the case for a majority of solid tumors, including neuroblastoma. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3183DOI Listing

Moringin from Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors.

Int J Mol Sci 2019 Apr 19;20(8). Epub 2019 Apr 19.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy.

In the last decades, glucosinolates (GLs), precursors of isothiocyanates (ITCs), have been studied mostly for their chemopreventive and chemotherapeutic properties. The aim of our research was to study the antiproliferative effect of 4-(α-L-rhamnopyranosyloxy) benzyl glucosinolate (glucomoringin; GMG) bioactivated by myrosinase enzyme to form the corresponding isothiocyanate 4-(α-L-rhamnopyranosyloxy) benzyl C (moringin) in SH-SY5Y human neuroblastoma cells. We found that moringin significantly reduced SH-SY5Y cell growth in a time and concentration-dependent ( < 0. Read More

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http://dx.doi.org/10.3390/ijms20081930DOI Listing

Majority of -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High.

JCO Precis Oncol 2019 4;3. Epub 2019 Mar 4.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Microsatellite instability-high (MSI-H) colorectal carcinomas (CRCs) show high rates of response to immune checkpoint inhibitors (IOs). mutations and protein loss have been proposed as causes of resistance to IOs, yet they are enriched in MSI-H CRC. We aimed to characterize -mutant, IO-naive CRC. Read More

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http://dx.doi.org/10.1200/PO.18.00321DOI Listing

Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity.

J Extracell Vesicles 2019 11;8(1):1597614. Epub 2019 Apr 11.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.

Neuroblastoma accounts for 15% of childhood cancer mortality. Amplification of the oncogene N-Myc is a well-established poor prognostic marker for neuroblastoma. Whilst N-Myc amplification status strongly correlates with higher tumour aggression and resistance to treatment, the role of N-Myc in the aggressiveness of the disease is poorly understood. Read More

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http://dx.doi.org/10.1080/20013078.2019.1597614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461098PMC

Regulation of Neprilysin Activity and Cognitive Functions in Rats After Prenatal Hypoxia.

Neurochem Res 2019 Apr 20. Epub 2019 Apr 20.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44 Thorez av, St. Petersburg, Russia, 194223.

The amyloid-degrading enzyme neprilysin (NEP) is one of the therapeutic targets in prevention and treatment of Alzheimer's disease (AD). As we have shown previously NEP expression in rat parietal cortex (Cx) and hippocampus (Hip) decreases with age and is also significantly reduced after prenatal hypoxia. Following the paradigms for enhancement of NEP expression and activity developed in cell culture, we analysed the efficacy of various compounds able to upregulate NEP using our model of prenatal hypoxia in rats. Read More

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http://link.springer.com/10.1007/s11064-019-02796-3
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http://dx.doi.org/10.1007/s11064-019-02796-3DOI Listing
April 2019
1 Read

Additional data support the role of rs11655237 C>T in the development of neuroblastoma.

Aging (Albany NY) 2019 Apr 20. Epub 2019 Apr 20.

, Department of Pediatric Surgery, Hunan Children's Hospital, Changsha, China.

Neuroblastoma is the most frequently diagnosed neural tumor of childhood. Abnormal function of the long intergenic non-coding RNA (lincRNA) has been implicated in various human malignancies. Genome-wide association studies revealed the rs11655237 C>T polymorphism to be associated with the risk of neuroblastoma, though the effect was not well defined, in part due to the small sample size in our earlier study. Read More

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http://www.aging-us.com/article/101920/text
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http://dx.doi.org/10.18632/aging.101920DOI Listing
April 2019
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A case report of a thymic neuroblastoma associated with syndrome of inappropriate secretion of antidiuretic hormone: Ten-year follow-up results after surgical treatment.

Authors:
Yukitoshi Satoh

Int J Surg Case Rep 2019 Apr 5;58:45-47. Epub 2019 Apr 5.

Department of Thoracic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara-shi, Kanagawa 252-0374, Japan. Electronic address:

Introduction: Thymic neuroblastoma with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in adults is an extremely rare and malignant neoplasm. Although the tumor is known to grow rapidly and have a poor prognosis, its etiology is still uncertain. In 2009, we described a case of thymic neuroblastoma with SIADH. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.056DOI Listing

Long non-coding RNA-p21 regulates MPP-induced neuronal injury by targeting miR-625 and derepressing TRPM2 in SH-SY5Y cells.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Blood Transfusion, Central Hospital of Linyi, No. 17, Health Road, Yishui County, 276400, Linyi City, Shandong Province, China. Electronic address:

Parkinson's disease (PD), the second most prevalent age-related neurodegenerative disease, occurs as a result of the loss of dopaminergic neurons in the substantia nigra. Long non-coding RNA-p21 (lnc-p21) has been demonstrated to be upregulated in PD. However, its role in PD is unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.017DOI Listing

Cytotoxicity screening of supercritical fluid extracted seaweeds and phenylpropanoids.

Mol Biol Rep 2019 Apr 19. Epub 2019 Apr 19.

Department of Bioengineering, Faculty of Engineering, Ege University, 35100, Bornova, Izmir, Turkey.

Detached leaves of Posidonia oceanica and Zostera marina creating nuisance at the shores were extracted by means of supercritical CO enriched with a co-solvent, compared with that of soxhlet extraction. The extracts and their active compounds which are phenylpropanoids (chicoric, p-coumaric, rosmarinic, benzoic, ferulic and caffeic acids) were screened for cytotoxicity in cancer cell lines including human breast adenocarcinoma (MCF-7, MDA-MB-231, SK-BR-3), human colon adenocarcinoma (HT-29), human cervix adenocarcinoma (HeLa), human prostate adenocarcinoma (PC-3), Mus musculus neuroblastoma (Neuro 2A) cell lines and African green monkey kidney (VERO) as healthy cell line. Supercritical CO extracts proved to be more active than soxhlet counterparts. Read More

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http://link.springer.com/10.1007/s11033-019-04812-9
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http://dx.doi.org/10.1007/s11033-019-04812-9DOI Listing
April 2019
1 Read

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Department of Molecular Engineering, University of Washington, Seattle, WA 98195;

Alzheimer's disease (AD) is characterized by the deposition of β-sheet-rich, insoluble amyloid β-peptide (Aβ) plaques; however, plaque burden is not correlated with cognitive impairment in AD patients; instead, it is correlated with the presence of toxic soluble oligomers. Here, we show, by a variety of different techniques, that these Aβ oligomers adopt a nonstandard secondary structure, termed "α-sheet." These oligomers form in the lag phase of aggregation, when Aβ-associated cytotoxicity peaks, en route to forming nontoxic β-sheet fibrils. Read More

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http://dx.doi.org/10.1073/pnas.1820585116DOI Listing

Tetrandrine induces apoptosis in human neuroblastoma through regulating the Hippo/YAP signaling pathway.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China. Electronic address:

Tetrandrine (TET), a bis-benzylisoquinoline alkaloid, shows cytotoxicity against several different types of tumors. However, the mechanism by which TET exerts its anti-cancer capabilities remains unclear. In this study, we confirmed that TET inhibits proliferation and induces apoptosis in neuroblastoma (NB) in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.075DOI Listing

Neuroprotective effect of Dictyopteris divaricata extract-capped gold nanoparticles against oxygen and glucose deprivation/reoxygenation.

Colloids Surf B Biointerfaces 2019 Mar 29;179:421-428. Epub 2019 Mar 29.

Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea; Department of Laboratory Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.

Combination therapy remains a promising approach to ameliorate cerebral ischemia injury. Nevertheless, the primary mechanism of the neuroprotective properties of Dictyopteris divaricata extract-capped gold nanoparticles (DD-GNPs) is not completely understood. DD-GNPs displayed maximum absorption at 525 nm and a diameter of 62. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.066DOI Listing

Could Hepatitis B Vaccine Act as An Adjuvant to Lower Risk and Relapses of Cancer?

Clin Exp Pharmacol Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Acibadem University, İstanbul, Turkey.

In this review article, we hypothesize that Hepatitis B Virus Vaccine (HBV-V) and certain antigens of Hepatitis B Virus (HBV)-could act as anticancer immunoadjuvants in addition to their role of preventing HBV-associated liver cancer. Evidence suggests that in animal breast cancer and melanoma models, combining hepatitis B-surface antigen (HBsAg) with other cancer antigens resulted in enhanced antitumor activity. HBsAg shares antigenic mimicry with healthy and malignant cells including squamous epithelia, thymic epithelia, bladder- and colon cancer cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13096DOI Listing
April 2019
1 Read

Benign differentiation of treated neuroblastoma as a cause of false positive by I-MIBG SPECT/CT. Usefulness of F-FDG PET/CT.

Rev Esp Med Nucl Imagen Mol 2019 Apr 15. Epub 2019 Apr 15.

ASCIRES CETIR Esplugues, Esplugues de Llobregat, Barcelona, España.

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https://linkinghub.elsevier.com/retrieve/pii/S2253654X183032
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http://dx.doi.org/10.1016/j.remn.2019.03.001DOI Listing
April 2019
1 Read

Diminished cytolytic activity of γδ T cells with reduced DNAM-1 expression in neuroblastoma patients.

Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China; Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China; Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. Electronic address:

Neuroblastoma is one of the children's malignant tumors with poor prognosis, as well as high recurrence and metastasis rates after surgical removal and chemotherapy. γδ T-cell based immunotherapy receives increasing attention thanks to their strong cytolytic activity to tumor cells. Our previous data revealed a significant increase in circulating γδ T-cell frequency in NB patients. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.006DOI Listing

Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.

JCI Insight 2019 Apr 18;5. Epub 2019 Apr 18.

Gain of the long arm of chromosome 17 (17q) is a cytogenetic hallmark of high-risk neuroblastoma, yet its contribution to neuroblastoma pathogenesis remains incompletely understood. Combining whole-genome and RNA sequencing of neuroblastomas, we identified the prohibitin (PHB) gene as highly expressed in tumors with 17q gain. High PHB expression correlated with poor prognosis and was associated with loss of gene expression programs promoting neuronal development and differentiation. Read More

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http://dx.doi.org/10.1172/jci.insight.127130DOI Listing
April 2019
1 Read

Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways.

Chem Sci 2019 Mar 10;10(9):2732-2742. Epub 2019 Jan 10.

Consiglio Nazionale delle Ricerche , Istituto di Biostrutture e Bioimmagini , Via P. Gaifami 18 , 95126 Catania , Italy . Email:

Several lines of evidence point to a compromised proteostasis associated with a reduction of the Ubiquitin Proteasome System (UPS) activity in patients affected by Alzheimer's Disease (AD) and suggest that the amyloid β peptide (Aβ) is an important player in the game. Inspired also by many reports, underlining the presence of ubiquitin (Ub) in the amyloid plaques of AD brains, here we set out to test whether Ub may bind the Aβ peptide and have any effect on its clearance pathways. By using an integrated array of MALDI-TOF/UPLC-HRMS, fluorescence, NMR, SPR, Microscale Thermophoresis (MST) and molecular dynamics studies, we consistently demonstrated that Aβ40 binds Ub with a 1 : 1 stoichiometry and in the high micromolar range. Read More

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http://xlink.rsc.org/?DOI=C8SC03394C
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http://dx.doi.org/10.1039/c8sc03394cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419943PMC
March 2019
1 Read

Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic.

J Biol Chem 2019 Apr 17. Epub 2019 Apr 17.

University of Auckland, New Zealand.

Amyloid β1-42 (Aβ1-42) peptide is involved in Alzheimer's disease (AD) pathogenesis and is prone to glycation, an irreversible process resulting in proteins with accumulated advanced glycated end products (AGEs). Nε-(carboxyethyl)lysine (CEL) is a common AD-associated AGE, occurring at either Lys-16 or Lys-28 of Aβ1-42. Methylglyoxal is commonly used for the unspecific glycation of Aβ1-42, which results in a complex mixture of AGE-modified peptides and makes interpretation of a causative AGE at a specific amino acid residue difficult. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.006846
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http://dx.doi.org/10.1074/jbc.RA118.006846DOI Listing
April 2019
2 Reads

MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease.

FASEB J 2019 Apr 17:fj201900363R. Epub 2019 Apr 17.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms due to the selective loss of midbrain dopaminergic neurons. The evidence for a chronic inflammatory reaction mediated by microglial cells in the brain is particularly strong in PD. In our previous study, we have shown that brain-specific microRNA-124 (miR-124) is significantly down-regulated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD and that it can also inhibit neuroinflammation during the development of PD. Read More

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http://dx.doi.org/10.1096/fj.201900363RDOI Listing

Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ aggregation.

Food Chem Toxicol 2019 Apr 14;129:1-12. Epub 2019 Apr 14.

Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50 - 50134, Florence, Italy; Interuniversity Center for the Study of Neurodegenerative Diseases (CIMN), Florence, Italy. Electronic address:

Oleuropein aglycone (OleA), the most abundant polyphenol in extra virgin olive oil (EVOO), and Hydroxythyrosol (HT), the OleA main metabolite, have attracted our interest due to their multitarget effects, including the interference with amyloid aggregation path. However, the mechanistic details of their anti-amyloid effect are not known yet. We report here a broad biophysical approach and cell biology techniques that enabled us to characterize the different molecular mechanisms by which OleA and HT modulate the Aβ fibrillation, a main histopathological feature of Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.015DOI Listing
April 2019
1 Read

Transmission of chromosomally integrated human herpes virus-6A via haploidentical stem cell transplantation poses a risk for virus reactivation and associated complications.

Bone Marrow Transplant 2019 Apr 15. Epub 2019 Apr 15.

Department of Pediatric Hematology and Oncology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1038/s41409-019-0530-4DOI Listing

ZC3H12B, a new active member of the ZC3H12 family.

RNA 2019 Apr 15. Epub 2019 Apr 15.

Department of Cell Biochemistry, Faculty of Biotechnology, Biochemistry and Biophysics, Jagiellonian University, Krakow, Poland.

ZC3H12B is the most enigmatic member of the ZC3H12 protein family. The founding member of this family, Regnase-1/MCPIP1/ZC3H12A, is a well-known modulator of inflammation and is involved in the degradation of inflammatory mRNAs. In this study, for the first time, we characterized the properties of the ZC3H12B protein. Read More

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http://rnajournal.cshlp.org/lookup/doi/10.1261/rna.071381.11
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http://dx.doi.org/10.1261/rna.071381.119DOI Listing
April 2019
1 Read

Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease.

J Food Drug Anal 2019 Apr 12;27(2):551-564. Epub 2019 Jan 12.

Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. Electronic address:

Alzheimer's disease (AD) is the most common cause of dementia in late life. It is difficult to precisely diagnose AD at early stages, making biomarker search essential for further developments. The objective of this study was to identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ). Read More

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http://dx.doi.org/10.1016/j.jfda.2018.11.009DOI Listing
April 2019
3 Reads
0.395 Impact Factor

Estimating transfection efficiency in differentiated and undifferentiated neural cells.

BMC Res Notes 2019 Apr 15;12(1):225. Epub 2019 Apr 15.

Behavioral Genetics Unit, Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia.

Objective: Delivery of constructs for silencing or over-expressing genes or their modified versions is a crucial step for studying neuronal cell biology. Therefore, efficient transfection is important for the success of these experimental techniques especially in post-mitotic cells like neurons. In this study, we have assessed the transfection rate, using a previously established protocol, in both primary cortical cultures and neuroblastoma cell lines. Read More

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http://dx.doi.org/10.1186/s13104-019-4249-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466792PMC

Second reported case of pediatric bladder alveolar soft part sarcoma as secondary malignancy after prior cytotoxic chemotherapy.

Urology 2019 Apr 12. Epub 2019 Apr 12.

Department of Pediatric Urology, Children's Mercy Hospital, Kansas City, MO, USA.

Alveolar soft part sarcoma (ASPS) is a rare malignancy with high rates of metastasis at presentation, defined by an unclear cellular origin and a unique unbalanced ASPSCR1-TFE3 translocation (der(17)t(X:17)(p11:q25)). ASPS is insensitive to chemotherapy and has been reported to involve the bladder only twice in the pediatric literature; once as a primary malignancy, and once as a secondary malignancy after cytotoxic chemotherapy. Herein, we report the third case of pediatric bladder ASPS in a female patient who received cytotoxic chemotherapy for low-risk neuroblastoma. Read More

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http://dx.doi.org/10.1016/j.urology.2019.04.002DOI Listing

Nuclear estrogen receptor activation by insulin-like growth factor-1 in Neuro-2A neuroblastoma cells requires endogenous estrogen synthesis and is mediated by mutually repressive MAPK and PI3K cascades.

Mol Cell Endocrinol 2019 Apr 13. Epub 2019 Apr 13.

Tulane Brain Institute, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA; Neuroscience Program, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA; Department of Psychology, Tulane University, 2007 Percival Stern Hall, New Orleans, LA, 70118, USA.

Non-canonical mechanisms of estrogen receptor activation may continue to support women's cognitive health long after cessation of ovarian function. These mechanisms of estrogen receptor activation may include ligand-dependent actions via locally synthesized neuroestrogens and ligand-independent actions via growth factor-dependent activation of intracellular kinase cascades. We tested the hypothesis that ligand-dependent and ligand-independent mechanisms interact to activate nuclear estrogen receptors in the Neuro-2A neuroblastoma cell line in the absence of exogenous estrogens. Read More

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http://dx.doi.org/10.1016/j.mce.2019.04.007DOI Listing

Nodal increases the malignancy of childhood neuroblastoma cells via regulation of Zeb1.

Biofactors 2019 Apr 15. Epub 2019 Apr 15.

Department of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou City, Guangdong Province, China.

Neuroblastoma (NB) is one of the most common malignant tumors derived from pluripotent cells of the neural crest. Nodal is an important embryonic morphogen which can re-express in cancer cells. The roles of Nodal in the progression of NB are not illustrated. Read More

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http://dx.doi.org/10.1002/biof.1505DOI Listing
April 2019
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Trends in International Incidence of Pediatric Cancers in Children Under 5 Years of Age: 1988-2012.

JNCI Cancer Spectr 2019 Mar 9;3(1):pkz007. Epub 2019 Apr 9.

Background: Pediatric cancer incidence has been steadily increasing over the last several decades with the largest increases reported in infants. Few evaluations have looked at international pediatric cancer incidence trends in the youngest children. The aim of this analysis was to evaluate trends in cancer incidence in children under 5 years of age, overall and by type, using data from () from 1988 to 2012 (CI5 volumes VII-XI). Read More

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http://dx.doi.org/10.1093/jncics/pkz007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455426PMC
March 2019
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Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of .

Avicenna J Phytomed 2019 Mar-Apr;9(2):143-152

Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.

Objective: In this study, our aim was to extract, and identify and quantify the chemical composition of essential oils of grown in Kerman, Iran. Moreover, cytotoxic, antioxidant and antimicrobial activity of the essential oil and methanol extract of aerial parts of were reported.

Materials And Methods: GC and GC/MS analysis were used for identifying and quantifying the essential oil components. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448547PMC
April 2019
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The neuroprotective effect of BSA-based nanocurcumin against 6-OHDA-induced cell death in SH-SY5Y cells.

Avicenna J Phytomed 2019 Mar-Apr;9(2):92-100

Nanobiology and Nanomedicine Research Centre, Shiraz University of Medical sciences, Shiraz, Iran.

Objective: Parkinson's disease (PD) is regarded as the second most common neurodegenerative disease affecting elderly population. There is a tendency toward finding natural cures to suppress the initiation and progression of this disease. Some epidemiological studies indicated lower incidence of PD in populations that consume curry. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448549PMC

Computational algorithms for in silico profiling of activating mutations in cancer.

Cell Mol Life Sci 2019 Apr 13. Epub 2019 Apr 13.

Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, USA.

Methods to catalog and computationally assess the mutational landscape of proteins in human cancers are desirable. One approach is to adapt evolutionary or data-driven methods developed for predicting whether a single-nucleotide polymorphism (SNP) is deleterious to protein structure and function. In cases where understanding the mechanism of protein activation and regulation is desired, an alternative approach is to employ structure-based computational approaches to predict the effects of point mutations. Read More

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http://dx.doi.org/10.1007/s00018-019-03097-2DOI Listing
April 2019
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Immune expression in children with Wilms tumor: a pilot study.

J Pediatr Urol 2019 Mar 20. Epub 2019 Mar 20.

Division of Surgical Sciences, Dept of Surgery, Duke University School of Medicine, Durham, NC, USA.

Background: Given improvements in multimodality therapy, survival among children with Wilms tumor (WT) exceeds 90%. However, 15% of children with favorable histology and 50% of children with anaplastic WT experience recurrence or progression. Of patients with advanced disease, only 50% survive to adulthood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14775131193006
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http://dx.doi.org/10.1016/j.jpurol.2019.03.011DOI Listing
March 2019
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Myristic acid specifically stabilizes diacylglycerol kinase δ protein in C2C12 skeletal muscle cells.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Jul 11;1864(7):1031-1038. Epub 2019 Apr 11.

Department of Chemistry, Graduate School of Science, Chiba University, Chiba 263-8522, Japan. Electronic address:

Decreased levels of the δ isozyme of diacylglycerol kinase (DGK) in skeletal muscle attenuate glucose uptake and, consequently, are critical for the pathogenesis of type 2 diabetes. We recently found that free myristic acid (14:0), but not free palmitic acid (16:0), increased the DGKδ protein levels and enhanced glucose uptake in C2C12 myotube cells. However, it has been unclear how myristic acid regulates the level of DGKδ2 protein. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.003DOI Listing
July 2019
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Glucocorticoid Receptor-Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses.

Endocrinology 2019 May;160(5):1044-1056

Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Mineralocorticoid and glucocorticoid receptors (MRs and GRs) constitute a functionally important dual receptor system detecting and transmitting circulating corticosteroid signals. High expression of MRs and GRs occurs in the same cells in the limbic system, the primary site of glucocorticoid action on cognition, behavior, and mood; however, modes of interaction between the receptors are poorly characterized. We used chromatin immunoprecipitation with nucleotide resolution using exonuclease digestion, unique barcode, and single ligation (ChIP-nexus) for high-resolution genome-wide characterization of MR and GR DNA binding profiles in neuroblastoma cells and demonstrate recruitment to highly similar DNA binding sites. Read More

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http://dx.doi.org/10.1210/en.2018-00819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462215PMC

Hospital admission for neurologic disorders among five-year survivors of non-central nervous system tumors in childhood: a cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study.

Int J Cancer 2019 Apr 13. Epub 2019 Apr 13.

Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.

Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of non-central nervous system (CNS) childhood cancers are lacking. Thus, the aim of this study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identified 15,967 five-year survivors of non-CNS childhood cancer diagnosed in Denmark, Iceland, Finland, and Sweden in 1943-2008, and 151,118 matched population comparison subjects. Read More

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http://dx.doi.org/10.1002/ijc.32341DOI Listing

Modulation of Endocannabinoid-Binding Receptors in Human Neuroblastoma Cells by Tunicamycin.

Molecules 2019 Apr 11;24(7). Epub 2019 Apr 11.

Department of Medicine, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Endocannabinoid (eCB)-binding receptors can be modulated by several ligands and membrane environment, yet the effect of glycosylation remains to be assessed. In this study, we used human neuroblastoma SH-SY5Y cells to interrogate whether expression, cellular localization, and activity of eCB-binding receptors may depend on -linked glycosylation. Following treatment with tunicamycin (a specific inhibitor of -linked glycosylation) at the non-cytotoxic dose of 1 µg/mL, mRNA, protein levels and localization of eCB-binding receptors, as well as -acetylglucosamine (GlcNAc) residues, were evaluated in SH-SY5Y cells by means of quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR), fluorescence-activated cell sorting (FACS), and confocal microscopy, respectively. Read More

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http://dx.doi.org/10.3390/molecules24071432DOI Listing
April 2019
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Chitosan Nanoparticles Rescue Rotenone-Mediated Cell Death.

Materials (Basel) 2019 Apr 11;12(7). Epub 2019 Apr 11.

Department of Chemistry & Biochemistry, The University of Texas at El Paso, El Paso, TX 79968, USA.

The aim of the present investigation was to study the anti-oxidant effect of chitosan nanoparticles on a human SH-SY5Y neuroblastoma cell line using a rotenone model to generate reactive oxygen species. Chitosan nanoparticles were synthesized using an ionotropic gelation method. The obtained nanoparticles were characterized using various analytical techniques such as Dynamic Light Scattering, Scanning Electron Microscopy, Transmission Electron Microscopy, Fourier Transmission Infrared spectroscopy and Atomic Force Microscopy. Read More

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https://www.mdpi.com/1996-1944/12/7/1176
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http://dx.doi.org/10.3390/ma12071176DOI Listing
April 2019
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Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells.

Prostaglandins Other Lipid Mediat 2019 Apr 9;142:59-67. Epub 2019 Apr 9.

Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden. Electronic address:

Relatively little is known about the endocannabinoid system in human neuroblastoma cell lines. In the present study, we have investigated the expression of the genes coding for the enzymes involved in the synthesis and catabolism of endocannabinoids in the SH-SY5Y cell line. The expression of MGLL, the gene coding for the 2-arachidonoylglycerol hydrolytic enzyme monoacylglycerol lipase (MAGL), was found to be 85 and 340 fold lower than the expression levels for the genes coding for alpha/beta-hydrolase domain containing 6 and 12 (ABHD6, ABHD12), which are alternative hydrolytic enzymes for this endocannabinoid. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.04.003DOI Listing
April 2019
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Melatonin ameliorates endoplasmic reticulum stress in N2a neuroblastoma cell hypoxia-reoxygenation injury by activating the AMPK-Pak2 pathway.

Cell Stress Chaperones 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery, Shanghai Pudong Hospital, Shanghai Fu Dan University School of Medicine, Shanghai, 201399, China.

Endoplasmic reticulum (ER) stress has been identified as a primary factor involved in brain ischemia-reperfusion injury progression. p21-activated kinase 2 (Pak2) is a novel ER function regulator. The aim of our study is to explore the influence of Pak2 on ER stress and determine whether melatonin attenuates ER stress-mediated cell death by modulating Pak2 expression in vitro using N2a cells. Read More

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http://link.springer.com/10.1007/s12192-019-00994-0
Publisher Site
http://dx.doi.org/10.1007/s12192-019-00994-0DOI Listing
April 2019
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3.163 Impact Factor