40,214 results match your criteria Neuroblastoma


Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones.

Bioorg Chem 2019 Feb 1;86:445-451. Epub 2019 Feb 1.

Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

In this work six PBN-related indanonitrones 1-6 have been designed, synthesized, and their neuroprotection capacity tested in vitro, under OGD conditions, in SH-SY5Y human neuroblastoma cell cultures. As a result, we have identified indanonitrones 1, 3 and 4 (EC = 6.64 ± 0. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.01.071DOI Listing
February 2019

Dual Effect of Doxazosin: Anticancer Activity on SH-SY5Y Neuroblastoma Cells and Neuroprotection on an In Vitro Model of Alzheimer's Disease.

Neuroscience 2019 Feb 13. Epub 2019 Feb 13.

Programa de Pós-Graduação em Ciências Biológicas-Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Several studies have demonstrated the antitumor effect of doxazosin, an α1-adrenergic blocker, against glioma and breast, bladder and prostate cancers. Doxazosin is also being evaluated as a treatment for posttraumatic stress disorder and alcoholism, and α1-adrenergic blockers have been linked to neuroprotection in neurodegenerative disorders, such as Alzheimer's Disease (AD). Cancer and AD have an inverse relationship in many aspects, with several factors that contribute to apoptosis inhibition and proliferation being increased in cancers but decreased in AD. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.005DOI Listing
February 2019

Methamphetamine regulates βAPP PROCESSING in human neuroblastoma cells.

Neurosci Lett 2019 Feb 13. Epub 2019 Feb 13.

Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand; Centre National de la Recherche Scientifique, 2 rue Michel Ange, 75016, Paris, France. Electronic address:

Methamphetamine is a potent and highly addictive psychostimulant whose abuse has turned out to be a global health hazard. The multitudinous effects it exerts at the cellular level induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Strikingly, brain changes, tissue damage and neuropsychological symptoms due to Meth exposure compels and necessitates to link the probability of risk of developing premature Alzheimer's disease, a progressive neurodegenerative disorder characterized by amyloid plaques composed of amyloid-β peptides and clinical dementia. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.023DOI Listing
February 2019

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.

Cell Mol Life Sci 2019 Feb 15. Epub 2019 Feb 15.

Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Passeig Vall d'Hebron 119-129, Collserola Building. Lab 207, 08035, Barcelona, Spain.

Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the genome, remains largely unexplored. RNA therapeutics is an emerging field that widens the range of druggable targets and includes elements such as microRNA. Read More

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http://dx.doi.org/10.1007/s00018-019-03041-4DOI Listing
February 2019

Synthesis and evaluation of Tc-analogues of [I]mIBG prepared via [Tc][Tc(CO)(HO)] synthon for targeting norepinephrine transporter.

Nucl Med Biol 2019 Jan 18. Epub 2019 Jan 18.

Homi Bhabha National Institute (HBNI), Anushaktinagar, Mumbai 400094, India; Radiopharmaceutical Division, Bhabha Atomic Research Centre (BARC), Trombay, Mumbai 400085, India.

Introduction: meta-[I]Iodobenzylguanidine (mIBG) is a clinical agent used for imaging neuroendocrine tumors, where uptake in tumor is via active transport mechanism through norepinephrine transporters (NET). Our group in past have evaluated a Tc-analogue of the above tracer, based on Tc-4 + 1 labeling approach, which exhibited significant affinity for NET but suffered from reduced specific uptake in comparison to reference standard no-carrier-added (n.c. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2019.01.001DOI Listing
January 2019

Dynamic effect of beta-amyloid 42 on cell mechanics.

J Biomech 2019 Jan 31. Epub 2019 Jan 31.

Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong; Centre for Robotics and Automation, City University of Hong Kong, Kowloon, Hong Kong. Electronic address:

Aβ, which is highly toxic to neural cells, is commonly present in the brains of people with Alzheimer's disease. In this study, dynamic changes in cell mechanics were monitored under Aβ-induced toxicity. To investigate the changes in cellular mechanical properties, we used Aβ oligomer at different concentrations to treat human neuroblastoma SH-SY5H cells. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2019.01.046DOI Listing
January 2019

Platinum(II) , Complexes Inhibit the Aggregation of Amyloid Model Systems.

Int J Mol Sci 2019 Feb 14;20(4). Epub 2019 Feb 14.

Department of Pharmacy, University of Naples Federico II, Napoli 80134, Italy.

Platinum(II) complexes with different cinnamic acid derivatives as ligands were investigated for their ability to inhibit the aggregation process of amyloid systems derived from Aβ, Yeast Prion Protein Sup35p and the C-terminal domain of nucleophosmin 1. Thioflavin T binding assays and circular dichroism data indicate that these compounds strongly inhibit the aggregation of investigated peptides exhibiting IC values in the micromolar range. MS analysis confirms the formation of adducts between peptides and Pt(II) complexes that are also able to reduce amyloid cytotoxicity in human SH-SY5Y neuroblastoma cells. Read More

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http://dx.doi.org/10.3390/ijms20040829DOI Listing
February 2019

Edaravone reduces Aβ-induced oxidative damage in SH-SY5Y cells by activating the Nrf2/ARE signaling pathway.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China. Electronic address:

Aims: Edaravone potentially alleviates cognitive deficits in a mouse model of Alzheimer's disease (AD). However, the mechanism of edaravone in suppressing AD progression remains unclear. We aim to investigate the mechanism of edaravone in suppressing oxidative stress-mediated AD progression in vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193011
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http://dx.doi.org/10.1016/j.lfs.2019.02.025DOI Listing
February 2019
2 Reads

Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells.

Toxicol Res 2019 Jan 15;35(1):83-91. Epub 2018 Jan 15.

Department of Veterinary Toxicology, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Korea.

Nanoparticles (NPs) have been recognized as both useful tools and potentially toxic materials in various industrial and medicinal fields. Previously, we found that zinc oxide (ZnO) NPs that are neurotoxic to human dopaminergic neuroblastoma SH-SY5Y cells are mediated by lipoxygenase (LOX), not cyclooxygenase-2 (COX-2). Here, we examined whether human bone marrow-derived mesenchymal stem cells (MSCs), which are different from neuroblastoma cells, might exhibit COX-2- and/or LOX-dependent cytotoxicity of ZnO NPs. Read More

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http://dx.doi.org/10.5487/TR.2019.35.1.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354944PMC
January 2019

Correction: Thrombospondin-targeting TAX2 peptide impairs tumor growth in preclinical mouse models of childhood neuroblastoma.

Pediatr Res 2019 Feb 14. Epub 2019 Feb 14.

Universite de Reims Champagne-Ardenne, UFR Sciences Exactes et Naturelles, Reims, France.

The authors "Revital Rattenbach", "ltschak Lamensdorf", and "Celine Martin" were not included in the author list of this published article however should be considered to be authors since they contributed substantially to the work. The updated author list of this article can be found in the associated correction. Read More

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http://dx.doi.org/10.1038/s41390-019-0329-4DOI Listing
February 2019

Maintaining a methods database to optimize solid tumor tissue culture: Review of a 15-year database from a single institution.

Cancer Genet 2019 Feb 2. Epub 2019 Feb 2.

Department of Pathology and Laboratory Medicine, Clinical Genetics and Genomics Laboratories, Children's Mercy Hospital, 2401 Gillham Rd, Kansas City, MO 64108, USA; Medical School, University of Missouri Kansas City, Kansas City, MO, USA. Electronic address:

Chromosome analysis of solid tumors provides valuable information for diagnosis and patient management, yet successfully culturing solid tumors can be challenging. The Children's Mercy (CM) Cytogenetics laboratory has compiled a database of 1371 non-lymphoma solid tumors cultured since 2002. Analysis of the tumor culture data found a culture success rate of 91. Read More

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http://dx.doi.org/10.1016/j.cancergen.2019.01.006DOI Listing
February 2019

MYCN-induced E2F5 promotes neuroblastoma cell proliferation through regulating cell cycle progression.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatrics, The Second Xiangya Hospital, Central South University, PR China.

The MYCN oncoprotein induces the proliferation of neuroblastoma cells through regulating gene transcription. The E2F transcription factor 5 (E2F5) plays an oncogenic role in several types of cancer, however, its role in neuroblastoma cells remains poorly characterized. We report here that MYCN positively regulates E2F5 expression in neuroblastoma cells. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.087DOI Listing
February 2019

The Pediatric Surgical Team: a Model for Increased Surgeon Index Case Exposure.

J Pediatr Surg 2019 Jan 21. Epub 2019 Jan 21.

Kapi'olani Medical Center for Children, 1319 Punahou St., Honolulu, HI, USA 96826.

Background/purpose: High surgical volume for both surgeons and hospital systems has been linked to improved outcomes for many surgical problems, yet case volumes per pediatric surgeon are diminishing nationally in complex pediatric surgery. We therefore sought to review our experience in a geographically isolated setting where a surgical team approach has been used to improve per-surgeon exposure to index pediatric surgical cases.

Methods: As a surgical group, we incorporated a surgical team approach to complex pediatric surgical cases in 2010. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.12.018DOI Listing
January 2019

Exploring Cancer Cell Behavior In Vitro in Three-Dimensional Multicellular Bioprintable Collagen-Based Hydrogels.

Cancers (Basel) 2019 Feb 5;11(2). Epub 2019 Feb 5.

Fondazione Instituto di Ricerca Pediatrica Citta' della Speranza, Neuroblastoma Laboratory, 35127 Padua, Italy.

In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor growth, invasion, and drug delivery. The 3D spheroid model of solid tumors has been the most popular cancer model in use until now. However, previous studies have shown that these spheroid models lack sufficient morphological parameters, which may affect their response to chemicals. Read More

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http://dx.doi.org/10.3390/cancers11020180DOI Listing
February 2019

Reduced-dose Radiation Therapy to the Primary Site is Effective for High-risk Neuroblastoma: Results from a Prospective Trial.

Int J Radiat Oncol Biol Phys 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York New York. Electronic address:

Purpose: For patients with high-risk neuroblastoma (HR-NB), a dose of 21 Gy to the primary tumor site after gross total resection (GTR) provides excellent local control. However, no clinical trial has specifically evaluated the optimal dose of radiation therapy (RT), and RT-related long-term toxicities are of increasing concern. We sought to assess local control, survival outcomes, and toxicity after a reduction in dose to the primary site from 21 Gy to 18 Gy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193019
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http://dx.doi.org/10.1016/j.ijrobp.2019.02.004DOI Listing
February 2019
5 Reads

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells.

PLoS One 2019 14;14(2):e0212089. Epub 2019 Feb 14.

Programa de Pós-Graduação em Ciências Farmacêuticas, Department of Pharmacy, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.

Alzheimer's disease (AD) is the most common form of dementia and has no cure. Therapeutic strategies focusing on the reduction of oxidative stress, modulation of amyloid-beta (Aβ) toxicity and inhibition of tau protein hyperphosphorylation are warranted to avoid the development and progression of AD. The aim of this study was to screen the crude extracts (CEs) and ethyl-acetate fractions (EAFs) of Guazuma ulmifolia, Limonium brasiliense, Paullinia cupana, Poincianella pluviosa, Stryphnodendron adstringens and Trichilia catigua using preliminary in vitro bioassays (acetylcholinesterase inhibition, antioxidant activity and total polyphenol content) to select extracts/fractions and assess their protective effects against Aβ25-35 toxicity in SH-SY5Y cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212089PLOS
February 2019

99mTc-LLEC Renal Dynamic Scan in a Patient With Pelvic Neuroblastoma.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Nuclear Medicine, JIPMER, Puducherry, Pondicherry, India.

A 5-month-old boy with ultrasonography showing bilateral hydronephrosis, referred for renal scan. On Tc-L,L,ethylenedicysteine (Tc-LLEC) renal scan, tracer blush in flow images in the region of urinary bladder was seen and tumor mass was suspected. Contrast-enhanced CT showed a soft tissue mass in sacrococcygeal region. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002491DOI Listing
February 2019

Technical Note: Simplified and practical pretherapy tumor dosimetry - A feasibility study for I-MIBG therapy of neuroblastoma using I-MIBG PET/CT.

Med Phys 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatrics, University of California, San Francisco, CA, USA.

Purpose: Radiation dose calculated on tumors for radiopharmaceutical therapy varies significantly from tumor to tumor and from patient to patient. Accurate estimation of radiation dose requires multiple time-point measurements using radionuclide imaging modalities such as SPECT or PET. In this report, we show our technical development of reducing the number of scans needed for reasonable estimation of tumor and normal organ dose in our pretherapy imaging and dosimetry platform of I-metaiodobenzylguanidine (MIBG) PET/CT for I-MIBG therapy of neuroblastoma. Read More

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http://dx.doi.org/10.1002/mp.13446DOI Listing
February 2019

Quantitative ubiquitylome analysis and crosstalk with proteome/acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma.

Transl Cancer Res 2018 Dec;7(6):1548-1560

Medical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Background: Perifosine, is a third generation alkylphospholipid analog which has promising anti-tumor efficacy in clinical trials of refractory/recurrent neuroblastoma (NB). However, perifosine's mechanism of action remains unclear. Previously, we have shown that perifosine changes global proteome and acetylome profiles in NB. Read More

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http://dx.doi.org/10.21037/tcr.2018.11.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370305PMC
December 2018

Association of Two Polymorphisms in CCL2 With Parkinson's Disease: A Case-Control Study.

Front Neurol 2019 29;10:35. Epub 2019 Jan 29.

Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Parkinson's disease (PD) is the most common neurodegenerative movement disorder that is known to be related to neuro-inflammation. Chemokines participate in this process usually through upregulation of expression levels, which are closely related to the polymorphisms in their genes. Recent studies have further revealed the association between these polymorphisms and the risk of PD in multiple populations, but not the Chinese Han population. Read More

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http://dx.doi.org/10.3389/fneur.2019.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362632PMC
January 2019
1 Read

Neuroblastoma-A Neural Crest Derived Embryonal Malignancy.

Front Mol Neurosci 2019 29;12. Epub 2019 Jan 29.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet (KI), Stockholm, Sweden.

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity with a disease spectrum ranging from spontaneous regression without any medical intervention to treatment resistant tumors with metastatic spread and poor patient survival. The events that lead to the development of neuroblastoma from the neural crest have not been fully elucidated. Read More

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http://dx.doi.org/10.3389/fnmol.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361784PMC
January 2019

Oxidative Stress Regulated Iron Regulatory Protein IRP2 Through FBXL5-Mediated Ubiquitination-Proteasome Way in SH-SY5Y Cells.

Front Neurosci 2019 29;13:20. Epub 2019 Jan 29.

Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, School of Basic Medicine, Qingdao University, Qingdao, China.

Iron regulatory protein 2 (IRP2) plays a key role in the cellular iron homeostasis and could be regulated by a variety of factors, such as oxidative stress, hypoxia and iron, etc. IRP2 depletion results in neurodegenerative movement disorder with the loss of neurons and accumulations of iron. Since oxidative stress extensively exists in several neurodegenerative diseases where iron accumulation also exists, it is important to clarify the mechanisms underlying the effects of oxidative stress on IRP2 expression and its consequence. Read More

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http://dx.doi.org/10.3389/fnins.2019.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361836PMC
January 2019

Integrative analysis based on survival associated co-expression gene modules for predicting Neuroblastoma patients' survival time.

Biol Direct 2019 Feb 13;14(1). Epub 2019 Feb 13.

Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.

Background: More than 90% of neuroblastoma patients are cured in the low-risk group while only less than 50% for those with high-risk disease can be cured. Since the high-risk patients still have poor outcomes, we need more accurate stratification to establish an individualized precise treatment plan for the patients to improve the long-term survival rate.

Results: We focus on extracting features and providing a workflow to improve survival prediction for neuroblastoma patients. Read More

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http://dx.doi.org/10.1186/s13062-018-0229-2DOI Listing
February 2019
1 Read

Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure-activity relationship with a strong BBB permeability.

Exp Mol Med 2019 Feb 12;51(2):12. Epub 2019 Feb 12.

Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea.

We extracted 15 pterosin derivatives from Pteridium aquilinum that inhibited β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and cholinesterases involved in the pathogenesis of Alzheimer's disease (AD). (2R)-Pterosin B inhibited BACE1, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with an IC of 29.6, 16. Read More

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http://www.nature.com/articles/s12276-019-0205-7
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http://dx.doi.org/10.1038/s12276-019-0205-7DOI Listing
February 2019
1 Read

5'-Iodotubercidin represses expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth.

J Biol Chem 2019 Feb 12. Epub 2019 Feb 12.

Departments of Pediatrics and Genetics, LSU Health Sciences Center, United States.

Insulinoma associated-1 (INSM1) is a key protein functioning as a transcriptional repressor in neuroendocrine differentiation and is activated by N-Myc in human neuroblastoma (NB). INSM1 modulates the phosphoinositide 3-kinase (PI3K)-AKT Ser/Thr kinase (AKT)-glycogen synthase kinase 3β (GSK3β) signaling pathway through a positive-feedback loop, resulting in N-Myc stabilization. Accordingly, INSM1 has emerged as a critical player closely associated with N-Myc in facilitating NB cell growth. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006761DOI Listing
February 2019

PRIMA-1-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level.

J Exp Clin Cancer Res 2019 Feb 12;38(1):69. Epub 2019 Feb 12.

CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Background: Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 activator, PRIMA-1, in inducing neuroblastoma cell death. Read More

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-
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http://dx.doi.org/10.1186/s13046-019-1066-6DOI Listing
February 2019
1 Read

The Evolution of Risk Classification for Neuroblastoma.

Children (Basel) 2019 Feb 11;6(2). Epub 2019 Feb 11.

Department of Pediatrics, Section of Hematology, Oncology and Stem Cell Transplantation, The University of Chicago, Chicago, IL 60637, USA.

Neuroblastoma is a tumor with great clinical heterogeneity. Patients in North America are risk-stratified using a number of features including age at diagnosis, disease stage, tumor histology, status (amplified versus nonamplified), and tumor cell ploidy. In this paper, we review the evidence for utilizing these features in the risk classification of neuroblastic tumors. Read More

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http://dx.doi.org/10.3390/children6020027DOI Listing
February 2019

Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells.

Int J Mol Sci 2019 Feb 11;20(3). Epub 2019 Feb 11.

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100 Bolzano, Italy.

Mutations in the gene (encoding parkin) have been linked to the most frequent known cause of recessive Parkinson's disease (PD), and parkin dysfunction represents a risk factor for sporadic PD. Parkin is widely neuroprotective through different cellular pathways, as it protects dopaminergic neurons from apoptosis in a series of cellular and animal models of PD. The mitochondrial protein apoptosis-inducing factor (AIF) is an important cell death effector, which, upon cellular stress in many paradigms, is redistributed from the mitochondria to the nucleus to function as a proapoptotic factor, mostly independent of caspase activity, while in normal mitochondria it functions as an antiapoptotic factor. Read More

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http://dx.doi.org/10.3390/ijms20030748DOI Listing
February 2019
2.862 Impact Factor

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells.

Cancer Cell 2019 Feb;35(2):221-237.e8

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

The high expression across multiple tumor types and restricted expression in normal tissues make B7-H3 an attractive target for immunotherapy. We generated chimeric antigen receptor (CAR) T cells targeting B7-H3 (B7-H3.CAR-Ts) and found that B7-H3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193000
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http://dx.doi.org/10.1016/j.ccell.2019.01.002DOI Listing
February 2019
7 Reads

Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes.

FASEB J 2019 Feb 12:fj201800972R. Epub 2019 Feb 12.

Surgical Bioengineering Laboratory, Department of Surgery, University of California-Davis, Sacramento, California, USA.

We have established early-gestation chorionic villus-derived placenta mesenchymal stromal cells (PMSCs) as a potential treatment for spina bifida (SB), a neural tube defect. Our preclinical studies demonstrated that PMSCs have the potential to cure hind limb paralysis in the fetal lamb model of SB via a paracrine mechanism. PMSCs exhibit neuroprotective function by increasing cell number and neurites, as shown by indirect coculture and direct addition of PMSC-conditioned media to the staurosporine-induced apoptotic human neuroblastoma cell line, SH-SY5Y. Read More

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http://dx.doi.org/10.1096/fj.201800972RDOI Listing
February 2019

Neuroblastoma of the Iris in Children.

J Pediatr Ophthalmol Strabismus 2019 Feb 8;56:e12-e16. Epub 2019 Feb 8.

Neuroblastoma of the iris is an extremely rare clinical entity. An otherwise healthy 2-month-old male infant presented to the oncology clinic with a nodular whitish iris lesion in his right eye. The excisional tumor biopsy was consistent with a pathological diagnosis of neuroblastoma with differentiation and negative MYCN gene mutation. Read More

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http://dx.doi.org/10.3928/01913913-20190125-01DOI Listing
February 2019

Grape seed proanthocyanidins protect N2a cells against ischemic injury via endoplasmic reticulum stress and mitochondrial associated pathways.

CNS Neurol Disord Drug Targets 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurosurgery, Yidu Central Hospital of Weifang, Qingzhou 262500, Shandong. China.

Background/objective: Grape seed proanthocyanidins (GSPs) are a group of polyphenolic bioflavonoids, which possess a variety of biological functions and pharmacological properties. We studied the neuroprotective effects of GSP against oxygen-glucose deprivation/reoxygenation (OGD/R) injury and the potential mechanisms in mouse neuroblastoma N2a cells.

Methods: OGD/R was conducted in N2a cells. Read More

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http://dx.doi.org/10.2174/1871527318666190212111650DOI Listing
February 2019
1 Read
2.628 Impact Factor

Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols.

J Enzyme Inhib Med Chem 2019 Dec;34(1):665-671

a Saint Petersburg State University , Saint Petersburg , Russian Federation.

Human thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing enzyme which plays a crucial role in regulating numerous redox signalling pathways within the cell. While its functioning is important in all cells, levels of TrxR1 expression are higher in cancer cells, possibly as an adaptation to much higher levels of reactive oxygen species and the need for more extensive DNA synthesis. This makes TrxR1 an attractive target for cancer therapy development. Read More

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http://dx.doi.org/10.1080/14756366.2019.1575372DOI Listing
December 2019

SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro.

Cancers (Basel) 2019 Feb 10;11(2). Epub 2019 Feb 10.

Molecular Inflammation Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Hansine Hansens veg 18, 9019 Tromsø, Norway.

Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not been extensively studied as a potential therapeutic target in neuroblastoma. Read More

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http://dx.doi.org/10.3390/cancers11020202DOI Listing
February 2019

Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells.

Sci Rep 2019 Feb 11;9(1):1771. Epub 2019 Feb 11.

Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan, Republic of China.

Protein arginine methyltransferase 1 (PRMT1) catalyzing the formation of asymmetric dimethylarginines has been implicated in cancer development, metastasis, and prognosis. In this study, we investigated the effects of low PRMT1 levels on a non-MYCN amplified neuroblastoma SK-N-SH cell line. Stable PRMT1-knockdown (PRMT1-KD) cells showed reduced growth rates and cell cycle arrest at G/M. Read More

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http://dx.doi.org/10.1038/s41598-018-38394-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370813PMC
February 2019

Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia.

Front Mol Neurosci 2019 25;12. Epub 2019 Jan 25.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

In humans, neurosecretory chromaffin cells control a number of important bodily functions, including those related to stress response. Chromaffin cells appear as a distinct cell type at the beginning of midgestation and are the main cellular source of adrenalin and noradrenalin released into the blood stream. In mammals, two different chromaffin organs emerge at a close distance to each other, the adrenal gland and Zuckerkandl organ (ZO). Read More

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http://dx.doi.org/10.3389/fnmol.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355685PMC
January 2019
1 Read

Phospho-substrate profiling of Epac-dependent protein kinase C activity.

Mol Cell Biochem 2019 Feb 9. Epub 2019 Feb 9.

Department of Biomedical Sciences, University of New England, 11 Hills Beach Rd, Biddeford, ME, 04005, USA.

Exchange protein directly activated by cAMP (Epac) and protein kinase A are effectors for cAMP with distinct actions and regulatory mechanisms. Epac is a Rap guanine nucleotide exchange factor that activates Rap1; protein kinase C (PKC) is a major downstream target of Epac-Rap1 signaling that has been implicated in a variety of pathophysiological processes, including cardiac hypertrophy, cancer, and nociceptor sensitization leading to chronic pain. Despite the implication of both Epac and PKC in these processes, few downstream targets of Epac-PKC signaling have been identified. Read More

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http://dx.doi.org/10.1007/s11010-019-03502-1DOI Listing
February 2019
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Outcomes after Proton Therapy for Treatment of Pediatric High-Risk Neuroblastoma.

Int J Radiat Oncol Biol Phys 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: Patients with high-risk neuroblastoma (HR-NBL) require radiation to the primary tumor site and sites of persistent metastatic disease. Proton radiotherapy (PRT) may promote organ sparing, but long-term outcomes have not been studied.

Methods: Sequential patients with HR-NBL received PRT: 2160 cGy(RBE) to primary tumor bed and persistent metastatic sites, with 3600 cGy(RBE) to gross residual disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193019
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http://dx.doi.org/10.1016/j.ijrobp.2019.01.095DOI Listing
February 2019
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Elucidating the inhibitory potential of Vitamin A against fibrillation and amyloid associated cytotoxicity.

Int J Biol Macromol 2019 Feb 7;129:333-338. Epub 2019 Feb 7.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. Electronic address:

Protein aggregation and amyloid fibrillation are associated with many serious human pathophysiologies like Alzheimer's, Parkinson's diseases, type II diabetes etc. A powerful strategy for controlling and understanding amyloid protein aggregation is the modulation of protein self-assembly. In this study, anti-fibrillation activity of vitamin A (VA) and its effect on the kinetics of amyloid formation of Aβ-42 peptide was investigated by employing various spectroscopic, imaging and computational approaches. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.134DOI Listing
February 2019

Increased myocardial F-FDG uptake as a marker of Doxorubicin-induced oxidative stress.

J Nucl Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Nuclear Medicine, Department of Health Sciences (DISSAL), University of Genoa, Largo R. Benzi 10, 16132, Genoa, Italy.

Background: Oxidative stress and its interference on myocardial metabolism play a major role in Doxorubicin (DXR) cardiotoxic cascade.

Methods: Mice models of neuroblastoma (NB) were treated with 5 mg DXR/kg, either free (Free-DXR) or encapsulated in untargeted (SL[DXR]) or in NB-targeting Stealth Liposomes (pep-SL[DXR] and TP-pep-SL[DXR]). Control mice received saline. Read More

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http://dx.doi.org/10.1007/s12350-019-01618-xDOI Listing
February 2019

Optimization and evaluation of an in vitro model of PEG-mediated fusion of nerve cell bodies.

J Clin Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. Electronic address:

Polyethylene glycol (PEG) is a cell membrane fusogen (de StGroth et al., 1980; Hoehn et al., 1978 [2]; Pontecorvo et al. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.037DOI Listing
February 2019
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Expression of cyclin D1 in clear cell sarcoma of kidney. Is it useful in differentiating it from its histological mimics?

Diagn Pathol 2019 Feb 8;14(1):13. Epub 2019 Feb 8.

Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Background: Clear cell sarcoma of the kidney (CCSK) is a rare malignant pediatric renal neoplasm with a heterogeneous histological appearance which often results in misdiagnosis. There are no specific immunohistochemical markers which can help in differentiating CCSK from other pediatric renal neoplasms. Recently Cyclin D1 has been investigated as a possible marker in this regard. Read More

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http://dx.doi.org/10.1186/s13000-019-0790-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368701PMC
February 2019
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New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease.

Molecules 2019 Feb 7;24(3). Epub 2019 Feb 7.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

Research on neurodegenerative brain disorders, namely the age-dependent Alzheimer's disease (AD), has been intensified in the last decade due to the absence of a cure and the recognized increasing of life expectancy for populations. To address the multifactorial nature and complexity of AD, a multi-target-directed ligand approach was herein employed, by designing a set of six selected hybrids (⁻) that combine in the same entity two pharmacophores: tacrine (TAC) and 2-phenylbenzothiazole (PhBTA). The compounds contain a methoxy substituent at the PhBTA moiety and have a variable length linker between that and the TAC moiety. Read More

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http://dx.doi.org/10.3390/molecules24030587DOI Listing
February 2019
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Myosin Va interacts with the exosomal protein spermine synthase.

Biosci Rep 2019 Feb 7. Epub 2019 Feb 7.

LNBIO/CNPEM, Campinas, Brazil

Myosin Va (MyoVa) is an actin-based molecular motor that plays key roles in the final stages of secretory pathways, including neurotransmitter release. Several studies have addressed how MyoVa coordinates the trafficking of secretory vesicles, but why this molecular motor is found in exosomes is still unclear. In this work, using a yeast two-hybrid screening system, we identified the direct interaction between the globular tail domain of MyoVa and four protein components of exosomes: the WD repeat-containing protein 48 (WDR48), the cold shock domain-containing protein E1 (CSDE1), the Tandem C2 Domain-Containing Protein 1 (TC2N) and the enzyme spermine synthase (SMS). Read More

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http://dx.doi.org/10.1042/BSR20182189DOI Listing
February 2019

Adrenocorticotropic Hormone-Dependent Cushing Syndrome Caused by an Olfactory Neuroblastoma.

Clin Med Insights Endocrinol Diabetes 2019 31;12:1179551419825832. Epub 2019 Jan 31.

Department of Endocrinology, Hospital Clinico San Carlos, Madrid, Spain.

Olfactory neuroblastoma (ONB) is an unusual malignant neoplasm originating from the olfactory neuroepithelium. Secretion of adrenocorticotropic hormone (ACTH) from this tumor has been exceptionally reported. We describe a young man with resistant hypertension and a cushingoid phenotype. Read More

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http://dx.doi.org/10.1177/1179551419825832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357293PMC
January 2019
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In Vitro Characterization of a Potent p53-MDM2 Inhibitor, RG7112 in Neuroblastoma Cancer Cell Lines.

Cancer Biother Radiopharm 2019 Feb 6. Epub 2019 Feb 6.

Department of Biochemistry and Molecular Biology, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Neuroblastoma (NB) is one of the most aggressive and common solid tumors in pediatrics. Development of effective new therapeutics for NB is in progress to help reduce mortality and morbidity of the disease, particularly in relapsed patients. The tumor suppressor protein p53 plays a critical role in multiple signaling pathways to maintain cellular hemostasis. Read More

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http://dx.doi.org/10.1089/cbr.2018.2732DOI Listing
February 2019
1.381 Impact Factor

Inhibition of N-myc expression sensitizes human neuroblastoma IMR-32 cells expressing caspase-8 to TRAIL.

Cell Prolif 2019 Feb 6:e12577. Epub 2019 Feb 6.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objectives: This study aims to explore the roles of N-myc and caspase-8 in TRAIL-resistant IMR-32 cells which exhibit MYCN oncogene amplification and lack caspase-8 expression.

Materials And Methods: We established N-myc-downregulated IMR-32 cells using shRNA lentiviral particles targeting N-myc and examined the effect the N-myc inhibition on TRAIL susceptibility in human neuroblastoma IMR-32 cells expressing caspase-8.

Results: Cisplatin treatment in IMR-32 cells increased the expression of death receptor 5 (DR5; TRAIL-R2), but not other receptors, via downregulation of NF-κB activity. Read More

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http://dx.doi.org/10.1111/cpr.12577DOI Listing
February 2019

The lzheimer's disease rapy with uroaid () study protocol: Assessing the safety and efficacy of Neuroaid II (MLC901) in patients with mild-to-moderate Alzheimer's disease stable on cholinesterase inhibitors or memantine-A randomized, double-blind, placebo-controlled trial.

Alzheimers Dement (N Y) 2019 23;5:38-45. Epub 2019 Jan 23.

Raffles Neuroscience Centre, 585 North Bridge Road, #02-00 Raffles Hospital, Singapore.

Background: Dementia is a large and growing health care burden globally, and its major cause is Alzheimer's disease (AD). MLC901 (Neuroaid II) is a simplified form of MLC601 (Neuroaid), a Traditional Chinese Medicine with neuroprotective and neuroproliferative properties in cellular and animal models of brain injury. MLC601 has been shown to modulate amyloid precursor protein (APP) processing in human neuroblastoma cell cultures and increase the levels of soluble APPα. Read More

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http://dx.doi.org/10.1016/j.trci.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352850PMC
January 2019
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Esthesioneuroblastoma: An Unusual Presentation with Intractable Headache.

Cureus 2018 Nov 28;10(11):e3653. Epub 2018 Nov 28.

Radiology, Osceola Regional Medical Center, Kissimmee, USA.

Esthesioneuroblastoma, also known as olfactory neuroblastoma, is a malignant tumor of the upper nasal cavity. This report illustrates the case of a 63-year-old woman who presented with intractable headaches. Subsequent radiologic evaluation and correlation with histopathologic analysis confirmed esthesioneuroblastoma. Read More

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http://dx.doi.org/10.7759/cureus.3653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351115PMC
November 2018
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SCAPER localizes to primary cilia and its mutation affects cilia length, causing Bardet-Biedl syndrome.

Eur J Hum Genet 2019 Feb 5. Epub 2019 Feb 5.

The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Beer Sheva, Israel.

Studies of ciliopathies have served in elucidating much of our knowledge of structure and function of primary cilia. We report humans with Bardet-Biedl syndrome who display intellectual disability, retinitis pigmentosa, obesity, short stature and brachydactyly, stemming from a homozyogous truncation mutation in SCAPER, a gene previously associated with mitotic progression. Our findings, based on linkage analysis and exome sequencing studies of two remotely related large consanguineous families, are in line with recent reports of SCAPER variants associated with intellectual disability and retinitis pigmentosa. Read More

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http://www.nature.com/articles/s41431-019-0347-z
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http://dx.doi.org/10.1038/s41431-019-0347-zDOI Listing
February 2019
9 Reads