2,631 results match your criteria Neurobiology of Learning and Memory [Journal]


Arc reactivity in accumbens nucleus, amygdala and hippocampus differentiates cue over context responses during reactivation of opiate withdrawal memory.

Neurobiol Learn Mem 2019 Feb 13. Epub 2019 Feb 13.

Univ. Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, F-33000 Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, F-33000 Bordeaux, France. Electronic address:

Opiate withdrawal induces an early aversive state which can be associated to contexts and/or cues, and re-exposure to either these contexts or cues may participate in craving and relapse. Nucleus accumbens (NAC), hippocampus (HPC) and basolateral amygdala (BLA) are crucial substrates for acute opiate withdrawal, and for withdrawal memory retrieval. Also HPC and BLA interacting with the NAC are suggested to respectively mediate the processing of context and cue representations of drug-related memories. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.02.007DOI Listing
February 2019

Cerebellum and Cognition: Does the Rodent Cerebellum Participate in Cognitive Functions?

Neurobiol Learn Mem 2019 Feb 13. Epub 2019 Feb 13.

Department of Psychological Science, University of Vermont, 2 Colchester Avenue, Burlington, VT 05405, USA. Electronic address:

There is a widespread, nearly complete consensus that the human and non-human primate cerebellum is engaged in non-motor, cognitive functions. This body of research has implicated the lateral portions of lobule VII (Crus I and Crus II) and the ventrolateral dentate nucleus. With rodents, however, it is not so clear. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193002
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.02.006DOI Listing
February 2019
1 Read

After-effects of repetitive anodal transcranial direct current stimulation on learning and memory in a rat model of Alzheimer's disease.

Neurobiol Learn Mem 2019 Feb 5. Epub 2019 Feb 5.

Bioengineering College of Chongqing University, Chongqing Engineering Research Center for Medical Electronics Technology, Chongqing 400030, China. Electronic address:

Repetitive anodal transcranial direct current stimulation (tDCS) in a rat model of Alzheimer's disease (AD) has been shown to have distinct neuroprotective effects. Moreover, the effects of anodal tDCS not only occur during the stimulation but also persist after the stimulation has ended (after-effects). Here, the duration of the after-effects induced by repetitive anodal tDCS was investigated based on our previous studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.02.002DOI Listing
February 2019

Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice.

Neurobiol Learn Mem 2019 Feb 5. Epub 2019 Feb 5.

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, United States. Electronic address:

Calpain-1 and calpain-2 are involved in the regulation of several signaling pathways and neuronal functions in the brain. Our recent studies indicate that calpain-1 is required for hippocampal synaptic plasticity, including long-term depression (LTD) and long-term potentiation (LTP) in field CA1. However, little is known regarding the contributions of calpain-1 to cerebellar synaptic plasticity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.02.005DOI Listing
February 2019
1 Read

Effects of DNA methyltransferase inhibition on pattern separation performance in mice.

Neurobiol Learn Mem 2019 Feb 4;159:6-15. Epub 2019 Feb 4.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht 6200 MD, the Netherlands. Electronic address:

Enhancement of synaptic plasticity through changes in neuronal gene expression is a prerequisite for improved cognitive performance. Moreover, several studies have shown that DNA methylation is able to affect the expression of (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.02.003DOI Listing
February 2019

Performance of the trial-unique, delayed non-matching-to-location (TUNL) task depends on AMPA/Kainate, but not NMDA, ionotropic glutamate receptors in the rat posterior parietal cortex.

Neurobiol Learn Mem 2019 Feb 4;159:16-23. Epub 2019 Feb 4.

Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada. Electronic address:

Working memory (WM), the capacity for short-term storage and manipulation of small quantities of information, depends on fronto-parietal circuits. However, the function of the posterior parietal cortex (PPC) in WM has gone relatively understudied in rodents. Recent evidence calls into question whether the PPC is necessary for all forms of WM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.02.001DOI Listing
February 2019

Epigenetics and memory: Emerging role of histone lysine methyltransferase G9a/GLP complex as bidirectional regulator of synaptic plasticity.

Neurobiol Learn Mem 2019 Jan 28;159:1-5. Epub 2019 Jan 28.

Department of Physiology, 2 Medical Drive, MD9, National University of Singapore, Singapore 117593, Singapore; Neurobiology/Aging Programme, Life Sciences Institute, Centre for Life Sciences, 28 Medical Drive, Singapore 117456, Singapore. Electronic address:

Various epigenetic modifications, including histone lysine methylation, play an integral role in learning and memory. The importance of the histone lysine methyltransferase complex G9a/GLP and its associated histone H3 lysine K9 dimethylation in memory formation and cognition, has garnered the attention of researchers in the past decade. Recent studies feature G9a/GLP as the 'bidirectional regulator of synaptic plasticity', the neural correlate of memory. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.01.013DOI Listing
January 2019

Mechanisms of sleep and circadian ontogeny through the lens of neurodevelopmental disorders.

Neurobiol Learn Mem 2019 Jan 19. Epub 2019 Jan 19.

Department of Neurology and F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, United States; Division of Sleep Medicine, Harvard Medical School, United States. Electronic address:

Sleep is a mysterious, developmentally regulated behavior fundamental for cognition in both adults and developing animals. A large number of studies offer a substantive body of evidence that demonstrates that the ontogeny of sleep architecture parallels brain development. Sleep deprivation impairs the consolidation of learned tasks into long-term memories and likely links sleep to the neural mechanisms underlying memory and its physiological roots in brain plasticity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193001
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.011DOI Listing
January 2019
3 Reads

Stress-induced impairment in goal-directed instrumental behaviour is moderated by baseline working memory.

Neurobiol Learn Mem 2019 Jan 18;158:42-49. Epub 2019 Jan 18.

Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Department of Medical and Clinical Psychology, Tilburg University, the Netherlands.

Acute stress has been found to impair goal-directed instrumental behaviour, a cognitively flexible behaviour that requires cognitive control. The current study aimed to investigate the role of individual differences in baseline and stress-induced changes in working memory (WM) on the shift to less goal-directed responding under stress. To this end, 112 healthy participants performed an instrumental learning task. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.01.010DOI Listing
January 2019
1 Read

Transient inactivation of the visual-associative nidopallium frontolaterale (NFL) impairs extinction learning and context encoding in pigeons.

Neurobiol Learn Mem 2019 Jan 18;158:50-59. Epub 2019 Jan 18.

Faculty for Psychology, Biopsychology, Institute for Cognitive Neuroscience, Ruhr University Bochum, Bochum, Germany.

Extinction learning is a fundamental learning process that enables organisms to continuously update knowledge about their ever-changing environment. When using visual cues as conditioned stimuli (CS), visual cortical areas of mammals are known to participate in extinction learning. The aim of the present study was to test whether similar processes can also be observed in birds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.01.012DOI Listing
January 2019

Glucocorticoid response to stress induction prior to learning is negatively related to subsequent motor memory consolidation.

Neurobiol Learn Mem 2019 Jan 10;158:32-41. Epub 2019 Jan 10.

KU Leuven, Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, Leuven, Belgium; KU Leuven, Leuven Brain Institute, Leuven, Belgium. Electronic address:

Hippocampal activity during early motor sequence learning is critical to trigger subsequent sleep-related consolidation processes. Based on previous evidence that stress-induced cortisol release modulates hippocampal activity, the current study investigates whether exposure to stress prior to motor sequence learning influences the ensuing learning and overnight consolidation process. Seventy-four healthy young adults were exposed to a stressor (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.01.009DOI Listing
January 2019

Okadaic acid attenuates short-term and long-term synaptic plasticity of hippocampal dentate gyrus neurons in rats.

Neurobiol Learn Mem 2019 Jan 8;158:24-31. Epub 2019 Jan 8.

Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran; Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA. Electronic address:

Protein phosphorylation states have a pivotal role in regulation of synaptic plasticity and long-term modulation of synaptic transmission. Serine/threonine protein phosphatase 1 (PP1) and 2A (PP2A) have a critical effect on various regulatory mechanisms involved in synaptic plasticity, learning and memory. Okadaic acid (OKA), a potent inhibitor of PP1 and PP2A, reportedly leads to cognitive decline and Alzheimer's disease (AD)-like pathology. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193000
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.007DOI Listing
January 2019
4 Reads

Resistance, vulnerability and resilience: A review of the cognitive cerebellum in aging and neurodegenerative diseases.

Neurobiol Learn Mem 2019 Jan 7. Epub 2019 Jan 7.

University of Washington School of Medicine, Seattle, WA, United States. Electronic address:

In the context of neurodegeneration and aging, the cerebellum is an enigma. Genetic markers of cellular aging in cerebellum accumulate more slowly than in the rest of the brain, and it generates unknown factors that may slow or even reverse neurodegenerative pathology in animal models of Alzheimer's Disease (AD). Cerebellum shows increased activity in early AD and Parkinson's disease (PD), suggesting a compensatory function that may mitigate early symptoms of neurodegenerative pathophysiology. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193000
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.004DOI Listing
January 2019
9 Reads

A role for N-acetylaspartylglutamate (NAAG) and mGluR3 in cognition.

Neurobiol Learn Mem 2019 Jan 7;158:9-13. Epub 2019 Jan 7.

Department of Biology, Georgetown University, Washington, DC, USA. Electronic address:

The peptide transmitter N-acetylaspartylglutamate (NAAG) and its receptor, the type 3 metabotropic glutamate receptor (mGluR3, GRM3), are prevalent and widely distributed in the mammalian nervous system. Drugs that inhibit the inactivation of synaptically released NAAG have procognitive activity in object recognition and other behavioral models. These inhibitors also reverse cognitive deficits in animal models of clinical disorders. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193000
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.006DOI Listing
January 2019
4 Reads

Post-encoding frontal theta activity predicts incidental memory in the reward context.

Authors:
Min Pu Rongjun Yu

Neurobiol Learn Mem 2019 Jan 7;158:14-23. Epub 2019 Jan 7.

School of Psychology, Center for Studies of Psychological Application and Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou, China; Department of Psychology, National University of Singapore, Singapore. Electronic address:

Memories for daily events require that individuals integrate initial fragile traces of events over time. Recent evidence suggests that reward anticipation enhances memory performance and amplifies frontal theta activity for remembered items vs. forgotten items. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193000
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.008DOI Listing
January 2019
7 Reads

No neuron is an island: Homeostatic plasticity and over-constraint in a neural circuit.

Neurobiol Learn Mem 2019 Jan 4. Epub 2019 Jan 4.

Center for Learning and Memory, and Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States. Electronic address:

To support computation the activity of neurons must vary within a useful range, which highlights one potential value of homeostatic plasticity. The interconnectedness of the brain, however, introduces the possibility that combinations of homeostatic mechanisms can produce over-constraint in which not all set points can be satisfied. We use a simulation of the cerebellum to investigate the potential for such conflict and its consequences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2019.01.005DOI Listing
January 2019

Memory deficits in males and females long after subchronic immune challenge.

Neurobiol Learn Mem 2019 Jan 3;158:60-72. Epub 2019 Jan 3.

Department of Psychology, University of Michigan, Ann Arbor, United States. Electronic address:

Memory impairments and cognitive decline persist long after recovery from major illness or injury, and correlate with increased risk of later dementia. Here we developed a subchronic peripheral immune challenge model to examine delayed and persistent memory impairments in females and in males. We show that intermittent injections of either lipopolysaccharides or Poly I:C cause memory decline in both sexes that are evident eight weeks after the immune challenge. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193000
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.003DOI Listing
January 2019
6 Reads

Misaligned core body temperature rhythms impact cognitive performance of hospital shift work nurses.

Neurobiol Learn Mem 2019 Jan 3. Epub 2019 Jan 3.

UAB School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Circadian rhythms greatly influence 24-h variation in cognition in nearly all organisms, including humans. Circadian clock impairment and sleep disruption are detrimental to hippocampus-dependent memory and negatively influence the acquisition and recall of learned behaviors. The circadian clock can become out of sync with the environment during circadian misalignment. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193000
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.002DOI Listing
January 2019
6 Reads

Using acute stress to improve episodic memory: The critical role of contextual binding.

Neurobiol Learn Mem 2019 Jan 2;158:1-8. Epub 2019 Jan 2.

Department of Psychology, University of California, Davis, CA 95618, USA; Center for Mind and Brain, University of California, Davis, CA 95618, USA.

Previous research has shown that encountering a brief stressor shortly after learning can be beneficial for memory. Recent studies, however, have shown that post-encoding stress does not benefit all recently encoded memories, and an adequate theoretical account of these effects remains elusive. The current study tested a contextual binding account of post encoding stress by examining the effect of varying the context in which the stressor was experienced. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427193000
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.001DOI Listing
January 2019
12 Reads

Dorsal hippocampal damage disrupts the auditory context-dependent attenuation of taste neophobia in mice.

Neurobiol Learn Mem 2018 Dec 15;157:121-127. Epub 2018 Dec 15.

Department of Psychobiology, Institute of Neurosciences, Center for Biomedical Research (CIBM), University of Granada, Spain.

Rodents exhibit neophobia for novel tastes, demonstrated by an initial reluctance to drink novel-tasting, potentially-aversive solutions. Taste neophobia attenuates across days if the solution is not aversive, demonstrated by increased consumption as the solution becomes familiar. This attenuation of taste neophobia is context dependent, which has been demonstrated by maintained reluctance to drink the novel tasting solution if the subject has to drink it after being brought to a novel environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.12.009DOI Listing
December 2018

Coupling of autonomic and central events during sleep benefits declarative memory consolidation.

Neurobiol Learn Mem 2018 Dec 16;157:139-150. Epub 2018 Dec 16.

Department of Cognitive Sciences, University of California Irvine, Irvine, CA, USA. Electronic address:

While anatomical pathways between forebrain cognitive and brainstem autonomic nervous centers are well-defined, autonomic-central interactions during sleep and their contribution to waking performance are not understood. Here, we analyzed simultaneous central activity via electroencephalography (EEG) and autonomic heart beat-to-beat intervals (RR intervals) from electrocardiography (ECG) during wake and daytime sleep. We identified bursts of ECG activity that lasted 4-5 s and predominated in non-rapid-eye-movement sleep (NREM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.12.008DOI Listing
December 2018

Effects of acute psychosocial stress on the neural correlates of episodic encoding: Item versus associative memory.

Neurobiol Learn Mem 2018 Dec 12;157:128-138. Epub 2018 Dec 12.

Saarland University, Germany.

Acute stress is known to modulate episodic memory, but little is known about the extent to, and the circumstances under, which stress affects encoding of item vs. inter-item associative information for words of different valences. Furthermore, the precise neuro-cognitive mechanisms underlying stress effects on episodic encoding in humans are largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.12.006DOI Listing
December 2018
3 Reads

Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory.

Neurobiol Learn Mem 2018 Dec 13;157:114-120. Epub 2018 Dec 13.

Department of Neuroscience, Institute for Medical Research, University of Belgrade, Serbia.

Associative memory plays a key role in everyday functioning, but it declines with normal ageing as well as due to various pathological states and conditions, thus impairing quality of life. Associative memory enhancement via neurostimulation over frontal areas resulted in limited success, while posterior stimulation sites seemed to be more promising. We hypothesized that anodal transcranial direct current stimulation (tDCS) of parietal areas would lead to higher performance in associative memory due to high connectivity between posterior parietal cortex (PPC) and hippocampus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.12.007DOI Listing
December 2018
1 Read

ADHD symptoms are associated with decreased activity of fast sleep spindles and poorer procedural overnight learning during adolescence.

Neurobiol Learn Mem 2018 Dec 12;157:106-113. Epub 2018 Dec 12.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

ADHD and its subclinical symptoms have been associated with both disturbed sleep and weakened overnight memory consolidation. As sleep spindle activity during NREM sleep plays a key role in both sleep maintenance and memory consolidation, we examined the association between subclinical ADHD symptoms and sleep spindle activity. Furthermore, we hypothesized that sleep spindle activity mediates the effect of ADHD symptoms on overnight learning outcome in a procedural memory task. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.12.004DOI Listing
December 2018
5 Reads

Higher sleep spindle activity is associated with fewer false memories in adolescent girls.

Neurobiol Learn Mem 2018 Dec 13;157:96-105. Epub 2018 Dec 13.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Background: Sleep facilitates the extraction of semantic regularities amongst newly encoded memories, which may also lead to increased false memories. We investigated sleep stage proportions and sleep spindles in the recollection of adolescents' false memories, and their potential sex-specific differences.

Methods: 196 adolescents (mean age 16. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183028
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.12.005DOI Listing
December 2018
1 Read

Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning.

Neurobiol Learn Mem 2018 Dec 7;157:86-95. Epub 2018 Dec 7.

Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan; Brain and Body System Science Institute, Saitama University, Saitama 338-8570, Japan; School of Life Science, South China Normal University, Guangzhou 510631, China. Electronic address:

CaMKII is a pivotal kinase that plays essential roles in synaptic plasticity. Apart from its signaling function, the structural function of CaMKII is becoming clear. CaMKII - F-actin interaction stabilizes actin cytoskeleton in a dendritic spine. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183027
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.12.003DOI Listing
December 2018
4 Reads

Genetic inactivation of hypoxia inducible factor 1-alpha (HIF-1α) in adult hippocampal progenitors impairs neurogenesis and pattern discrimination learning.

Neurobiol Learn Mem 2018 Dec 3;157:79-85. Epub 2018 Dec 3.

Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, United States. Electronic address:

HIF-1α is a hypoxia-inducible protein that regulates many cellular processes, including neural stem cell maintenance. Previous work demonstrated constitutive stabilization of HIF-1α in neural stem cells (NSCs) of the adult mouse subventricular zone (SVZ) and hippocampal subgranular zone (SGZ). Genetic inactivation of NSC-encoded HIF-1α in the adult SVZ results in gradual loss of NSCs, but whether HIF-1α is required for the maintenance of SGZ hippocampal progenitors and adult hippocampal neurogenesis has not been determined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.12.002DOI Listing
December 2018
3 Reads

Enhancing effects of acute exposure to cannabis smoke on working memory performance.

Neurobiol Learn Mem 2018 Dec 3;157:151-162. Epub 2018 Dec 3.

Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA; Department of Psychology, University of Florida, Gainesville, FL, USA. Electronic address:

Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how acute exposure to cannabis smoke affects working memory performance in a rat model. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183027
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.12.001DOI Listing
December 2018
20 Reads

Acute psychosocial stress effects on memory performance: Relevance of age and sex.

Neurobiol Learn Mem 2018 Nov 29;157:48-60. Epub 2018 Nov 29.

Laboratory of Cognitive Social Neuroscience, Department of Psychobiology and IDOCAL, University of Valencia, Valencia, Spain.

In recent decades, there has been a growing interest in investigating the effects of chronic and acute stress on cognitive processes, especially memory performance. However, research focusing on acute stress effects has reported contradictory findings, probably due to the many factors that can moderate this relationship. In addition to factors related to the individual, such as sex and age, other factors, such as the type of memory assessed, can play a critical role in the direction of these effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.013DOI Listing
November 2018

Altered trajectories of neurodevelopment and behavior in mouse models of Rett syndrome.

Neurobiol Learn Mem 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Hugo W. Moser Research Institute at Kennedy Krieger, Inc., Baltimore, MD 21205, USA. Electronic address:

Rett Syndrome (RTT) is a genetic disorder that is caused by mutations in the x-linked gene coding for methyl-CpG-biding-protein 2 (MECP2) and that mainly affects females. Male and female transgenic mouse models of RTT have been studied extensively, and we have learned a great deal regarding RTT neuropathology and how MeCP2 deficiency may be influencing brain function and maturation. In this manuscript we review what is known concerning structural and coinciding functional and behavioral deficits in RTT and in mouse models of MeCP2 deficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.007DOI Listing
November 2018
1 Read

High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss.

Neurobiol Learn Mem 2018 Nov 22;157:41-47. Epub 2018 Nov 22.

Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, United States; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, United States; Minneapolis Center for Veterans Research and Education, Minneapolis, MN, United States. Electronic address:

Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of Alzheimer's disease (AD). Diets high in saturated fat potentiate the onset of obesity, microglial activation, and neuroinflammation. Signaling deficiencies in the hypothalamic peptide orexin and/or orexin fiber loss are linked to neurodegeneration, cognitive impairment, and neuroinflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.008DOI Listing
November 2018
18 Reads

Distinct subcellular changes in proteasome activity and linkage-specific protein polyubiquitination in the amygdala during the consolidation and reconsolidation of a fear memory.

Neurobiol Learn Mem 2018 Nov 17;157:1-11. Epub 2018 Nov 17.

Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. Electronic address:

Numerous studies have supported a critical role for the ubiquitin-proteasome system (UPS) in the memory consolidation and reconsolidation processes. The protein targets and functional role of ubiquitin-proteasome activity can vary widely across cellular compartments, however, it is unknown how UPS activity changes within the nuclear, cytoplasmic, and synaptic regions in response to learning or memory retrieval. Additionally, while previous studies have focused on degradation-specific protein polyubiquitination, it is unknown how learning alters other polyubiquitin tags that are not targeted by the proteasome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.012DOI Listing
November 2018

Chronic administration of gonadotropin releasing-hormone improves learning in old gonadectomized rats.

Neurobiol Learn Mem 2018 Nov 17;157:35-40. Epub 2018 Nov 17.

Physiology and Pharmacology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940 C.P. 20131, Aguascalientes, Mexico. Electronic address:

The aim of this study was to determine whether chronic administration of GnRH improves performance of learning tasks and expression of spinophilin in the hippocampus of gonadectomized old rats. Eighteen-month-old male Wistar rats were used and divided into three groups: control (intact rats); gonadectomized; and gonadectomized + GnRH. The latter group was injected intramuscularly with GnRH (100 nM) twice a day for five weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.010DOI Listing
November 2018
1 Read

Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits.

Neurobiol Learn Mem 2018 Nov 17;157:12-23. Epub 2018 Nov 17.

School of Biology, Damghan University, Damghan, Iran.

Stress as a homeostatic challenge leads to the malfunction of learning and memory processes, namely social learning and memory. The orexin system is involved in stress responses through connections to the hypothalamic-pituitary axis (HPA). In addition, the hippocampus, a structure vulnerable to stress-induced changes, expresses orexin receptors 1 and 2 (OXr1 and OXr2) in various sub-regions. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183026
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.11.009DOI Listing
November 2018
8 Reads

PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats.

Neurobiol Learn Mem 2018 Nov 17;157:24-34. Epub 2018 Nov 17.

Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, United States.

The stress-related neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is implicated in neuromodulation of learning and memory. PACAP can alter synaptic plasticity and has direct actions on neurons in the amygdala and hippocampus that could contribute to its acute and persistent effects on the consolidation and expression of conditioned fear. We recently demonstrated that intracerebroventricular (ICV) infusion of PACAP prior to fear conditioning (FC) results in initial amnestic-like effects followed by hyper-expression of conditioned freezing with repeated testing, and analyses of immediate-early gene c-Fos expression suggested that the central nucleus of the amygdala (CeA), but not the lateral/basolateral amygdala (LA/BLA) or hippocampus, are involved in these PACAP effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.011DOI Listing
November 2018
8 Reads

Leveraging the genetic basis of Rett syndrome to ascertain pathophysiology.

Neurobiol Learn Mem 2018 Nov 14. Epub 2018 Nov 14.

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

Mutations in the methyl-CpG binding protein 2 (MECP2) gene cause Rett syndrome (RTT), a progressive X-linked neurological disorder characterized by loss of developmental milestones, intellectual disability and breathing abnormality. Despite being a monogenic disorder, the pathogenic mechanisms by which mutations in MeCP2 impair neuronal function and underlie the RTT symptoms have been challenging to elucidate. The seemingly simple genetic root and the availability of genetic data from RTT patients have led to the generation and characterization of a series of mouse models recapitulating RTT-associated genetic mutations. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183026
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.11.006DOI Listing
November 2018
17 Reads

Memory systems 2018 - Towards a new paradigm.

Authors:
J Ferbinteanu

Neurobiol Learn Mem 2018 Nov 13;157:61-78. Epub 2018 Nov 13.

Dept. of Physiology and Pharmacology, Dept. of Neurology, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 31, Brooklyn, NY 11203, USA. Electronic address:

The multiple memory systems theory (MMS) postulates that the brain stores information based on the independent and parallel activity of a number of modules, each with distinct properties, dynamics, and neural basis. Much of the evidence for this theory comes from dissociation studies indicating that damage to restricted brain areas cause selective types of memory deficits. MMS has been the prevalent paradigm in memory research for more than thirty years, even as it has been adjusted several times to accommodate new data. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183026
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.11.005DOI Listing
November 2018
16 Reads

ADRB2 gene polymorphism modulates the retention of fear extinction memory.

Neurobiol Learn Mem 2018 Dec 10;156:96-102. Epub 2018 Nov 10.

Peking University Sixth Hospital, Peking University Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China. Electronic address:

Individual differences in regulation of fear and extinction memory play significant roles in the aetiology development of post-traumatic stress disorder (PTSD). Previous animal based studies showed that the activity of β-adrenergic receptors (β-ARs) are involved in memory modulation. However in humans it is not clear that whether genetic variability in β-ARs contributes to individual differences of fear and extinction memory. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.004DOI Listing
December 2018
2 Reads

Visuospatial word search task only effective at disrupting declarative memory when prediction error is present during retrieval.

Neurobiol Learn Mem 2018 Dec 8;156:80-85. Epub 2018 Nov 8.

Department of Neuroscience, Muhlenberg College, Allentown, PA, USA.

Prediction error is recognized as a necessary boundary condition for memory reactivation and reconsolidation. Furthermore, behavioral manipulations (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.003DOI Listing
December 2018

Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice.

Neurobiol Learn Mem 2018 Dec 5;156:103-116. Epub 2018 Nov 5.

Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States. Electronic address:

The dorsal hippocampus (DH) and medial prefrontal cortex (mPFC) are brain regions essential for processing and storing episodic memory. In rodents, the DH has a well-established role in supporting the consolidation of episodic-like memory in tasks such as object recognition and object placement. However, the role of the mPFC in the consolidation of episodic-like memory tasks remains controversial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.11.002DOI Listing
December 2018
12 Reads

Involvement of classical neurotransmitter systems in memory reconsolidation: Focus on destabilization.

Neurobiol Learn Mem 2018 Dec 2;156:68-79. Epub 2018 Nov 2.

Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Ontario, Canada. Electronic address:

When consolidated long-term memories are reactivated they can destabilize, rendering the memory labile and vulnerable to modification. This period of lability is followed by reconsolidation, a process that restabilizes the memory trace. Reactivation-induced memory destabilization is the gateway process to reconsolidation, but research in this area has focused primarily on the mechanisms underlying post-reactivation restabilization. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183025
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.11.001DOI Listing
December 2018
12 Reads

Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm.

Neurobiol Learn Mem 2018 Dec 27;156:60-67. Epub 2018 Oct 27.

Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA. Electronic address:

Discrimination of similar spatial locations, an important feature of episodic memory, has traditionally been measured via delayed nonmatching-to-location tasks. Recently, we and others have demonstrated that touchscreen-based Trial Unique Nonmatching-to-Location (TUNL) tasks are sensitive to lesions of the dorsal hippocampus in the mouse. Previously we have shown that loss of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor in the dorsal CA1 and throughout the cortex impairs hippocampal-dependent water maze and fear conditioning paradigms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300131PMC
December 2018
2 Reads

The conditions that regulate formation of a false fear memory in rats.

Neurobiol Learn Mem 2018 Dec 22;156:53-59. Epub 2018 Oct 22.

School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

People and animals sometimes associate events that never occurred together. These false memories can have disastrous consequences, yet little is known about the conditions under which they form. In four experiments, we investigated how rats learn to fear a context in which they have never experienced danger (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.10.009DOI Listing
December 2018

The effect of energy-matched exercise intensity on brain-derived neurotrophic factor and motor learning.

Neurobiol Learn Mem 2018 Dec 22;156:33-44. Epub 2018 Oct 22.

Department of Exercise Science, University of South Carolina, 921 Assembly St, Columbia, SC 29208, United States. Electronic address:

Background: Pairing a bout of high-intensity exercise with motor task practice can enhance motor learning beyond task practice alone, which is thought, in part, to be facilitated by an exercise-related increase in brain-derived neurotrophic factor (BDNF). The purpose of the current study was to examine the effect of different exercise intensities on BDNF levels and motor learning while controlling for exercise-related energy expenditure.

Methods: Forty-eight young, healthy participants were assigned to one of three groups: high-intensity exercise [High], low-intensity exercise [Low], or quiet rest [Rest]. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183024
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.10.008DOI Listing
December 2018
21 Reads

Impact of stress response systems on forced choice recognition in an experimental trauma film paradigm.

Neurobiol Learn Mem 2018 Dec 21;156:45-52. Epub 2018 Oct 21.

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Germany.

Introduction: Traumatic events are often followed by memory impairments of key features of the trauma. Stress hormones are involved in emotional memory formation. However, little is known about their influence during trauma on subsequent recognition memory. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183024
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.10.010DOI Listing
December 2018
8 Reads

Poor between-session recall of extinction learning and hippocampal activation and connectivity in children.

Neurobiol Learn Mem 2018 Dec 19;156:86-95. Epub 2018 Oct 19.

Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, United States; Department of Pharmaceutical Sciences, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, United States; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States.

Background: In healthy adults, successful between-session recall of extinction learning depends on the hippocampus and ventromedial prefrontal cortex (vmPFC), especially when tested in the extinction context. Poor extinction recall and dysfunction within hippocampal-vmPFC circuitry are associated with fear-based disorders (e.g. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183024
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286149PMC
December 2018
14 Reads

Bridging the species gap in translational research for neurodevelopmental disorders.

Neurobiol Learn Mem 2018 Oct 19. Epub 2018 Oct 19.

The UC Davis MIND Institute, University of California, Davis, United States; Department of Psychiatry and Behavioral Sciences, University of California, Davis, United States; California National Primate Research Center, University of California, Davis, United States. Electronic address:

The prevalence and societal impact of neurodevelopmental disorders (NDDs) continue to increase despite years of research in both patient populations and animal models. There remains an urgent need for translational efforts between clinical and preclinical research to (i) identify and evaluate putative causes of NDD, (ii) determine their underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches, and (iv) translate basic research into safe and effective clinical practices. Given the complexity behind potential causes and behaviors affected by NDDs, modeling these uniquely human brain disorders in animals will require that we capitalize on unique advantages of a diverse array of species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.10.006DOI Listing
October 2018

Inhibiting gustatory thalamus or medial amygdala has opposing effects on taste neophobia.

Neurobiol Learn Mem 2018 Dec 15;156:24-32. Epub 2018 Oct 15.

University of Illinois at Chicago, Department of Psychology, United States. Electronic address:

Taste neophobia is a feeding system defense mechanism that limits consumption of an unknown, and therefore potentially dangerous, edible until the post-ingestive consequences are experienced. We found that transient pharmacological inhibition (induced with the GABA agonists baclofen and muscimol) of the gustatory thalamus (GT; Experiment 1), but not medial amygdala (MeA; Experiment 2), during exposure to a novel saccharin solution attenuated taste neophobia. In Experiment 3 we found that inhibition of MeA neurons (induced with the chemogenetic receptor hM4DGi) enhanced the expression of taste neophobia whereas excitation of MeA neurons (with hM3DGq) had no influence of taste neophobia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309437PMC
December 2018

Hippocampal Homer1b/c is necessary for contextual fear conditioning and group I metabotropic glutamate receptor mediated long-term depression.

Neurobiol Learn Mem 2018 Dec 15;156:17-23. Epub 2018 Oct 15.

Cellular and Molecular Pathology Graduate Program, University of Wisconsin-Madison, Medical Sciences Center, 1300 University Ave, Room 73 Bardeen, Madison, WI 53706, USA; Department of Neurology, University of Wisconsin, Madison, WI, USA. Electronic address:

Coiled-coil forms of Homer1, including Homer1b and c (Homer1b/c) have been shown to play a role in hippocampal learning and memory and synaptic plasticity. We have previously found that overexpression of hippocampal Homer1c is sufficient to rescue learning and memory ability in aged learning impaired rats and in Homer1 knockout (KO) mice, and to rescue group I metabotropic glutamate receptor (mGluR1/5) mediated long-term potentiation in KO mice. Here, to determine if Homer1b/c is necessary for successful learning and memory we have utilized a rAAV5 vector expressing a Homer1b/c-targeting short hairpin RNA to knock down the expression of hippocampal Homer1b/c in adult 4-6-month old male Sprague Dawley rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nlm.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226007PMC
December 2018

Computational models of memory consolidation and long-term synaptic plasticity during sleep.

Neurobiol Learn Mem 2018 Oct 12. Epub 2018 Oct 12.

Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address:

The brain stores memories by persistently changing the connectivity between neurons. Sleep is known to be critical for these changes to endure. Research on the neurobiology of sleep and the mechanisms of long-term synaptic plasticity has provided data in support of various theories of how brain activity during sleep affects long-term synaptic plasticity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10747427183023
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2018.10.003DOI Listing
October 2018
9 Reads