331 results match your criteria NeuroSignals[Journal]


Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis.

Neurosignals 2018 Nov 27;26(1):77-93. Epub 2018 Nov 27.

Neurology Department with Institute of Translational Neurology, University of Münster, Münster, Germany.

Background/aims: Multiple sclerosis (MS) is a prototypical autoimmune central nervous system (CNS) disease. Particularly progressive forms of MS (PMS) show significant neuroaxonal damage as consequence of demyelination and neuronal hyperexcitation. Immuno-modulatory treatment strategies are beneficial in relapsing MS (RMS), but mostly fail in PMS. Read More

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November 2018
4 Reads

The Critical Role of Intrinsic Membrane Oscillations.

Neurosignals 2018 Sep 27;26(1):66-76. Epub 2018 Sep 27.

Center for Translational Neuroscience, Little Rock, Arkansas, USA.

Intrinsic, rhythmic subthreshold oscillations have been described in neurons of regions throughout the brain and have been found to influence the timing of action potentials induced by synaptic inputs. Some oscillations are sodium channel-dependent while others are calcium channel-dependent. These oscillations allow neurons to fire coherently at preferred frequencies and represent the main mechanism for maintaining high frequency network activity, especially in the cortex. Read More

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September 2018
1 Read

Ethylenediaminetetraacetic Acid Inhibits Vibrio Vulnificus-Induced Dendritic Cell Apoptosis by Lowering [Ca2+]i.

Neurosignals 2018 May 22;26(1):58-65. Epub 2018 May 22.

Department of Immunopathology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing University, Jiaxing, China.

Background/aims: Vibrio vulnificus (V. vulnificus) is a Gram-negative marine bacterium that can cause life-threatening primary septicemia, especially in the innate immune system. But how V. Read More

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May 2018
1 Read

Endomorphin-2 Inhibits the Activity of the Spinoparabrachial Projection Neuron through Presynaptic Mechanisms in the Spinal Dorsal Horn in Rats.

Neurosignals 2018 Mar 15;26(1):43-57. Epub 2018 Mar 15.

Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, China.

Background/aims: Spinal dorsal horn (SDH) is one of the most important regions for analgesia produced by endomorphin-2 (EM2), which has a higher affinity and specificity for the µ-opioid receptor (MOR) than morphine. Many studies have focused on substantia gelatinosa (SG, lamina II) neurons to elucidate the cellular basis for its antinociceptive effects. However, the complicated types and local circuits of interneurons in the SG make it difficult to understand the real effects of EM2. Read More

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March 2018
6 Reads

Brain Beta-Catenin Signalling During Stress and Depression.

Neurosignals 2018 Feb 22;26(1):31-42. Epub 2018 Feb 22.

Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway. In the canonical Wnt signalling pathway, beta-catenin again plays multiple roles. In the embryonic stage, the regulation of beta-catenin levels activates genes that govern cell proliferation and differentiation. Read More

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February 2018
1 Read

The Myth of Blunted Gamers: No Evidence for Desensitization in Empathy for Pain after a Violent Video Game Intervention in a Longitudinal fMRI Study on Non-Gamers.

Neurosignals 2018 Jan 31;26(1):22-30. Epub 2018 Jan 31.

University Clinic Hamburg-Eppendorf, Clinic and Policlinic for Psychiatry and Psychotherapy, Hamburg, Germany.

Background/aims: It is a common concern in the research field and the community that habitual violent video gaming reduces empathy for pain in its players. However, previous fMRI studies have only compared habitual game players against control participants cross-sectionally. However the observed pattern of results may be due to a priori differences in people who become gamers and who not. Read More

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January 2018
2 Reads

Association between COMT Polymorphism Val158Met and Opioid Consumption in Patients with Postoperative Pain: A Meta-Analysis.

Neurosignals 2018 Jan 25;26(1):11-21. Epub 2018 Jan 25.

Department of Immunopathology and Diabetes Institute, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing University, Jiaxing, China.

Background/aims: Several factors influencing postoperative pain and the effect of opioid analgesics have been investigated on an individual level. The aim of this study was to clarify the impact of catecholamine-O-methyltransferase (COMT) gene Val158Met on opioid consumption in postoperative patients.

Methods: A systematic review and meta-analysis of the literature up to September 30, 2017, were performed by using PubMed, Cochrane Library, ISI Web of Science, and Chinese National Knowledge Infrastructure (CNKI) database. Read More

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January 2018
4 Reads

Introducing a Virtual Lesion Model of Dysphagia Resulting from Pharyngeal Sensory Impairment.

Neurosignals 2018 Jan 25;26(1):1-10. Epub 2018 Jan 25.

University Hospital Muenster, Department of Neurology, Muenster, Germany.

Background/aims: Performing neurophysiological and functional imaging studies in severely affected patients to investigate novel neurostimulation techniques for the treatment of neurogenic dysphagia is difficult. Therefore, basic research needs to be conducted in healthy subjects. Swallowing is a motor function highly dependent on sensory afferent input. Read More

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January 2018
4 Reads

Decreased Fronto-Parietal and Increased Default Mode Network Activation is Associated with Subtle Cognitive Deficits in Elderly Controls.

Neurosignals 2017 18;25(1):127-138. Epub 2017 Dec 18.

Affidea Carouge Radiologic Diagnostic Center, Geneva, Switzerland.

Background: Cognitive functions progressively deteriorate during aging and neurodegenerative diseases. The present study aims at investigating differences in working memory performance as well as functional brain changes during the earliest stages of cognitive decline in health elderly individuals.

Methods: 62 elderly individuals (41 females), including 41 controls (35 females) and 21 middle cognitive impairment subjects (6 females), underwent neuropsychological assessment at baseline and an fMRI examination in a N-back paradigm contrasting 2-back vs. Read More

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December 2017
14 Reads

Neurons, Erythrocytes and Beyond -The Diverse Functions of Chorein.

Neurosignals 2017 28;25(1):117-126. Epub 2017 Nov 28.

Department of Biochemistry, University of Crete Medical School, Heraklion, Greece.

Chorea-acanthocytosis (ChAc), a neurodegenerative disease, results from loss-of-function-mutations of the chorein-encoding gene VPS13A. Affected patients suffer from a progressive movement disorder including chorea, parkinsonism, dystonia, tongue protrusion, dysarthria, dysphagia, tongue and lip biting, gait impairment, progressive distal muscle wasting, weakness, epileptic seizures, cognitive impairment, and behavioral changes. Those pathologies may be paralleled by erythrocyte acanthocytosis. Read More

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November 2017
6 Reads

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics.

Neurosignals 2017 13;25(1):98-116. Epub 2017 Nov 13.

Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, China.

Endomorphin-1 (EM1) and endomorphin-2 (EM2) are two endogenous ligands that belong to the opioid peptide family and have the highest affinity and selectivity for the µ-opioid receptor (MOR). The neuroanatomical distribution, ultrastructural features and neural circuitry of EM-containing neuronal structures have been morphologically demonstrated. In addition, the modulation effects of the EMs in different areas reflect their potential endogenous roles in many major physiological processes, including their remarkable roles in the transmission and modulation of noxious information. Read More

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November 2017
6 Reads

Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System.

Neurosignals 2017 6;25(1):88-97. Epub 2017 Nov 6.

Dept. of Neurology, University Hospital of the Saarland, Homburg, Germany.

Background: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several novel treatment options, the disease is still poorly controlled, since the pathophysiological mechanisms are not fully understood.

Methods: We tested the role of the acid sphingomyelinase/ceramide system in a model of MS, i. Read More

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November 2017
13 Reads

Increase of Substance P Concentration in Saliva after Pharyngeal Electrical Stimulation in Severely Dysphagic Stroke Patients - an Indicator of Decannulation Success?

Neurosignals 2017 17;25(1):74-87. Epub 2017 Oct 17.

University Hospital Muenster, Department of Neurology, Albert-Schweitzer-Campus 1 A, Muenster, Germany.

Background/aims: Substance P (SP) is a neuropeptide, likely acting as a neurotransmitter in the pharyngeal mucosa enhancing the swallow and cough reflex. Pharyngeal Electrical Stimulation (PES) induces a temporary increase of salivary SP levels in healthy adults. Previous evidence suggests that post-stroke dysphagia is related to reduced SP levels. Read More

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October 2017
14 Reads

Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited.

Neurosignals 2017 17;25(1):54-73. Epub 2017 Oct 17.

The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i.e. Read More

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October 2017
10 Reads

Stimulation of Anxiety-Like Behavior via ERK Pathway by Competitive Serotonin Receptors 2A and 1A in Post-Traumatic Stress Disordered Mice.

Neurosignals 2017 6;25(1):39-53. Epub 2017 Oct 6.

Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.

Background/aims: Serotonin 5HT2A and 5HT1A receptors (5HT2AR, 5HT1AR) have the closest connection to anxiety-like behavior in post-traumatic stress disorder (PTSD). However, the underlying mechanism remains unclear. In this study, we explored the connection between 5HT2A and 5HT1A receptors and anxiety-like behavior. Read More

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October 2017
11 Reads

Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells.

Neurosignals 2017 1;25(1):26-38. Epub 2017 Sep 1.

Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.

Background/aims: Glioblastoma (GBM) is one of the most aggressive cancers, counting for a high number of the newly diagnosed patients with central nervous system (CNS) cancers in the United States and Europe. Major features of GBM include aggressive and invasive growth as well as a high resistance to treatment. Kv1. Read More

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September 2017
12 Reads

The Spatial Extent of Epiretinal Electrical Stimulation in the Healthy Mouse Retina.

Neurosignals 2017 26;25(1):15-25. Epub 2017 Jul 26.

Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University, Tuebingen, Germany.

Background/aims: Retinal prostheses use electrical stimulation to restore functional vision to patients blinded by retinitis pigmentosa. A key detail is the spatial pattern of ganglion cells activated by stimulation. Therefore, we characterized the spatial extent of network-mediated electrical activation of retinal ganglion cells (RGCs) in the epiretinal monopolar electrode configuration. Read More

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July 2017
4 Reads

Improved Neural Regeneration with Olfactory Ensheathing Cell Inoculated PLGA Scaffolds in Spinal Cord Injury Adult Rats.

Neurosignals 2017 30;25(1):1-14. Epub 2017 Mar 30.

Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.

Background/aims: Every year, around the world, between 250000 and 500000 people suffer from spinal cord injury (SCI). This study investigated the potential for poly (lactic-co-glycolic acid) (PLGA) complex inoculated with olfactory ensheathing cells (OECs) to treat spinal cord injury in a rat model.

Methods: OECs were identified by immunofluorescence based on the nerve growth factor receptor (NGFR) p75. Read More

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March 2017
12 Reads

SGK3 Sensitivity of Large-Conductance Ca2+-Activated K+ Channel.

Neurosignals 2016 30;24(1):113-124. Epub 2016 Nov 30.

Department of Cardiology, Vascular Medicine and Physiology, University of Tübingen, Tübingen, Germany.

Background/aims: Large conductance Ca2+-activated K+ channels (maxi K+ channels or BK channels) are rapidly activated by increase of cytosolic Ca2+ activity. The channels participate in the regulation of diverse functions including neuronal excitation and cell volume. The BK channels may be modified by kinases. Read More

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November 2016
18 Reads

Cortical Responses and Shape Complexity of Stereoscopic Image - A Simultaneous EEG/MEG Study.

Neurosignals 2016 24;24(1):102-112. Epub 2016 Oct 24.

School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju, Korea.

Background/aims: In exploring human factors, stereoscopic 3D images have been used to investigate the neural responses associated with excessive depth, texture complexity, and other factors. However, the cortical oscillation associated with the complexity of stereoscopic images has been studied rarely. Here, we demonstrated that the oscillatory responses to three differently shaped 3D images (circle, star, and bat) increase as the complexity of the image increases. Read More

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October 2016
4 Reads

Leptin Regulates Tau Phosphorylation through Wnt Signaling Pathway in PC12 Cells.

Neurosignals 2016 24;24(1):95-101. Epub 2016 Oct 24.

Experimental teaching center, Basic Medical College of Henan University of Chinese Medicine, Zhengzhou, China.

Background/aims: Leptin, an adipocytokine produced endogenously in the brain, is decreased in Alzheimer's disease(AD) and has also been shown to reduce Aβ levels in vitro and in vivo. Sets of evidence show that leptin reduces Aβ production and tau phosphorylation in neuronal cells and transgenic mice models of AD. Herein, we investigated the signaling pathway activated by leptin, to better understand its mechanism of action. Read More

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October 2016
5 Reads

Leptin-Sensitive JAK2 Activation in the Regulation of Tau Phosphorylation in PC12 Cells.

Neurosignals 2016 8;24(1):88-94. Epub 2016 Sep 8.

Department of Physiology, Sanquan Medical College, Xinxiang Medical University, Xinxiang, China.

Background/aims: Alzheimer's disease (AD) is characterized by two major hallmarks: the deposition and accumulation of β-amyloid (Aβ) peptide and hyperphosphorylated tau in intracellular neurofibrillary tangles. Sets of evidence show that leptin reduces Aβ production and tau phosphorylation. Herein, we investigated the signaling pathways activated by leptin, to extensively understand its mechanism. Read More

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September 2016
10 Reads

Curcumin Protects against Monosodium Glutamate Neurotoxicity and Decreasing NMDA2B and mGluR5 Expression in Rat Hippocampus.

Neurosignals 2016 17;24(1):81-87. Epub 2016 Aug 17.

Biochemistry Department, Faculty of Pharmacy, AL-Delta University, Gamasa,Egypt.

Background: Monosodium glutamate (MSG) is a flavor enhancer used in food industries. MSG is well documented to induce neurotoxicity. Curcumin (CUR) reportedly possesses beneficial effects against various neurotoxic insults. Read More

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August 2016
16 Reads

Gut Taste Stimulants Alter Brain Activity in Areas Related to Working Memory: a Pilot Study.

Neurosignals 2016 27;24(1):59-70. Epub 2016 Jul 27.

Department of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.

Background/aims: Taste perception is one of the most important primary oral reinforcers, driving nutrient and energy intake as well as toxin avoidance. Taste receptors in the gastrointestinal tract might as well impact appetitive or aversive behavior and thus influence learning tasks and a close relation of neural taste processing and working memory networks seems plausible.

Methods: In the present pilot study, we determined the effects of five taste qualities "bitter" (quinine), "sweet" (glucose), "sour" (citric acid), "salty" (NaCl) and "umami" (monosodium glutamate, MSG) on working memory processing using functional MRI and their effect on plasma insulin and glucose levels. Read More

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July 2016
5 Reads

Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System.

Neurosignals 2016 11;24(1):48-58. Epub 2016 Jul 11.

Dept. of Surgery, University of Cincinnati, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.

Background: Melatonin has been shown to have antidepressive effects. We tested whether melatonin inhibits the acid sphingomyelinase/ceramide system and mediates its antidepressive effects via inhibition of the acid sphingomyelinase and a reduction of ceramide in the hippocampus. Antidepressants such as amitriptyline and fluoxetine were previously shown to inhibit the acid sphingomyelinase/ceramide system, which mediates neurogenesis and behavioral changes induced by these drugs. Read More

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July 2016
5 Reads

Wnt / ß-Catenin Signaling Pathway Against Aβ Toxicity in PC12 Cells.

Neurosignals 2016 20;24(1):40-47. Epub 2016 Jun 20.

Department of Basic Medicine, Luohe medical College, Luohe, China.

Background/aims: Alzheimer's disease (AD) is characterized by accumulation of β-amyloid (Aβ), However, the mechanism of how Aβ affects neuronal cell death remains elusive. The balance of pro- and anti-apoptotic Bcl-2 family proteins (e.g. Read More

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June 2016
4 Reads

Nogo-p4 Suppresses TrkA Signaling Induced by Low Concentrations of Nerve Growth Factor Through NgR1 in Differentiated PC12 Cells.

Neurosignals 2016 13;24(1):25-39. Epub 2016 Jun 13.

Department of Pathophysiology and High Altitude Pathology, College of High Altitude Military Medicine ,Third Military Medical University, Chongqing, P. R. China.

Background: Regeneration of injured axons in adult mammalian central nervous system (CNS) is not spontaneous. Nogo is a major inhibitory molecule contributing to axon regeneration failure. The molecular mechanisms of Nogo inhibition of axon regeneration are not completely understood. Read More

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June 2016
4 Reads

Early Postoperative Nociceptive Threshold and Production of Brain-Derived Neurotrophic Factor Induced by Plantar Incision Are Not Influenced with Minocycline in a Rat: Role of Spinal Microglia.

Neurosignals 2016 4;24(1):15-24. Epub 2016 Mar 4.

Division of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Background: Brain-derived neurotrophic factor (BDNF) from spinal microglia is crucial for aberrant nociceptive signaling in several pathological pain conditions, including postoperative pain. We assess the contribution of spinal microglial activation and associated BDNF overexpression to the early post-incisional nociceptive threshold.

Methods: Male Sprague-Dawley rats were implanted with an intrathecal catheter. Read More

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March 2016
12 Reads

Role of Serum Brain Derived Neurotrophic Factor and Central N-Acetylaspartate for Clinical Response under Antidepressive Pharmacotherapy.

Neurosignals 2016 1;24(1):1-14. Epub 2016 Feb 1.

Department of Psychiatry and Psychotherapy, Charité, University Medicine Berlin, Campus Mitte, Berlin, Germany.

Background: The predictive therapeutic value of brain derived neurotrophic factor (BDNF) and its changes associated with the use of specific antidepressants are still unclear. In this study, we examined BDNF as a peripheral and NAA as a central biomarker over the time course of antidepressant treatment to specify both of their roles in the response to the medication and clinical outcome.

Methods: We examined serum BDNF (ELISA kit) in a sample of 76 (47 female and 29 male) depressed patients in a naturalistic setting. Read More

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February 2016
8 Reads

Up-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by ß-Klotho.

Neurosignals 2015 19;23(1):59-70. Epub 2015 Dec 19.

Department of Physiology I, University of Tx00FC;bingen, Tx00FC;bingen, Germany.

Background/aims: Klotho, a transmembrane protein expressed in chorioid plexus of the brain, kidney, and several other tissues, is required for inhibition of 1,25(OH)2D3 formation by FGF23. The extracellular domain of Klotho protein could be cleaved off, thus being released into blood or cerebrospinal fluid. At least in part by exerting β-glucuronidase activity, soluble klotho regulates several ion channels and carriers. Read More

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October 2016
3 Reads

Sphingolipids in Major Depression.

Neurosignals 2015 19;23(1):49-58. Epub 2015 Dec 19.

Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.

Major depression is one of the most common and severe diseases affecting the world's population. However, the pathogenesis of the disease remains inadequately defined. Previously, a lack of monoaminergic neurotransmitters was the focus of pathophysiological concepts; however, recent concepts focus on a alteration of neurogenesis in the hippocampus. Read More

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October 2016
1 Read

Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology.

Neurosignals 2015 19;23(1):71-83. Epub 2015 Dec 19.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience King's College London, London, UK.

Background/aims: Previous diffusion tensor imaging (DTI) studies have shown microstructural changes in the brain white matter of at-risk mental state (ARMS) subjects for psychosis and patients with first-episode psychosis (FEP). However, only a few studies have been conducted in clinical high-risk samples and findings in both groups are inconsistent, in particular along the superior longitudinal fasciculus (SLF).

Methods: This DTI study used tract-based spatial statistics (TBSS) to compare fractional anisotropy (FA) and mean diffusivity (MD) between ARMS subjects, untreated and antipsychotic-treated FEP patients and healthy controls (HC) across the whole brain and the SLF. Read More

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October 2016
9 Reads

Lithium-Sensitive Store-Operated Ca2+ Entry in the Regulation of FGF23 Release.

Neurosignals 2015 17;23(1):34-48. Epub 2015 Dec 17.

Department of Physiology, University of Tuebingen, Tuebingen, Germany.

Background/aims: Lithium, a widely used drug for the treatment of mood disorders, has previously been shown to stimulate the release of fibroblast growth factor FGF23, a powerful regulator of 1,25(OH)2D3 formation and mineral metabolism. The cellular mechanisms involved have remained elusive. Lithium has been shown to modify Ca2+ signaling. Read More

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October 2016
4 Reads

SPAK and OSR1 Sensitive Kir2.1 K+ Channels.

Neurosignals 2015 17;23(1):20-33. Epub 2015 Dec 17.

Department of Physiology I, University of Tuebingen, Tuebigen, Germany.

Background/aims: Kir2.1 (KCNJ2) channels are expressed in neurons, skeletal muscle and cardiac tissue and maintain the resting membrane potential. The activity of those channels is regulated by diverse signalling molecules. Read More

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October 2016
6 Reads

Regulation of the Na+,Cl- Coupled Creatine Transporter CreaT (SLC6A8) by the Janus Kinase JAK3.

Neurosignals 2015 14;23(1):11-9. Epub 2015 Dec 14.

Department of Physiology I, University of Tx00FC;bingen, Germany.

Background: The creatine transporter CreaT (SLC6A8), a Na+,Cl- coupled transporter is expressed in diverse tissues including the brain. Genetic defects of SLC6A8 result in mental retardation with seizures. The present study explored the regulation of CreaT by Janus kinase JAK3, which is expressed in a variety of tissues including the brain and participates in the regulation of cell survival and differentiation of neuronal precursor cells. Read More

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October 2016
4 Reads

Chorein Sensitive Dopamine Release from Pheochromocytoma (PC12) Cells.

Neurosignals 2015 10;23(1):1-10. Epub 2015 Dec 10.

Department of Physiology, University of Tx00FC;bingen, Tx00FC;bingen, Germany.

Background: Chorein, a protein supporting activation of phosphoinositide 3 kinase (PI3K), participates in the regulation of actin polymerization and cell survival. A loss of function mutation of the chorein encoding gene VPS13A (vacuolar protein sorting-associated protein 13A) leads to chorea-acanthocytosis (ChAc), a neurodegenerative disorder with simultaneous erythrocyte akanthocytosis. In blood platelets chorein deficiency has been shown to compromise expression of vesicle-associated membrane protein 8 (VAMP8) and thus degranulation. Read More

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October 2016
43 Reads

Electrophysiological Features of Neurons in the Mesencephalic Trigeminal Nuclei.

Neurosignals 2014 9;22(2):79-91. Epub 2015 Jan 9.

Institute of Neuroscience, The Fourth Military Medical University, Xi'an, PR China.

Mesencephalic trigeminal nucleus (Mes V) neurons represent an uncommon class of primary sensory neurons. Besides receiving somatosensory information, Mes V neurons are also involved in regulating multisensory information. The present review first describes the passive features as well as three important currents, followed by a distinct excitability classification and a description of the excitability transition of Mes V neurons. Read More

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December 2015
3 Reads

Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface.

Neurosignals 2014 8;22(2):65-78. Epub 2014 Oct 8.

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Va., USA.

The small- and intermediate-conductance Ca(2+)-activated potassium (SK/IK) channels play important roles in the regulation of excitable cells in both the central nervous and cardiovascular systems. Evidence from animal models has implicated SK/IK channels in neurological conditions such as ataxia and alcohol use disorders. Further, genome-wide association studies have suggested that cardiovascular abnormalities such as arrhythmias and hypertension are associated with single nucleotide polymorphisms that occur within the genes encoding the SK/IK channels. Read More

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December 2015
9 Reads

Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.

Neurosignals 2014 31;22(1):52-63. Epub 2014 Jul 31.

Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.

Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study demonstrates that CAG stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. Read More

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October 2015
25 Reads

Regulator of G protein signaling transcript expression in human neural progenitor differentiation: R7 subfamily regulation by DNA methylation.

Neurosignals 2014 4;22(1):43-51. Epub 2014 Jun 4.

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Ga., USA.

G protein-coupled receptors (GPCRs) and their ligands are critical regulators of neural progenitor differentiation, and GPCR signaling pathways are regulated by regulator of G protein signaling (RGS) proteins. RGS protein expression is dynamically regulated, and we have recently described the epigenetic regulation of RGS transcript expression. Given the potential of RGS proteins to regulate GPCR signaling and the established role of epigenetic regulation in progenitor differentiation, we explored the impact of epigenetic regulation of RGS transcripts during in vitro differentiation of human neural progenitors. Read More

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October 2015
7 Reads

AxonQuant: A Microfluidic Chamber Culture-Coupled Algorithm That Allows High-Throughput Quantification of Axonal Damage.

Neurosignals 2014 28;22(1):14-29. Epub 2014 Feb 28.

School of Electronic Science and Engineering, Nanjing University, Nanjing, China.

Published methods for imaging and quantitatively analyzing morphological changes in neuronal axons have serious limitations because of their small sample sizes, and their time-consuming and nonobjective nature. Here we present an improved microfluidic chamber design suitable for fast and high-throughput imaging of neuronal axons. We developed the AxonQuant algorithm, which is suitable for automatic processing of axonal imaging data. Read More

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October 2015
6 Reads

Hedgehog and Notch signaling in enteric nervous system development.

Neurosignals 2014 14;22(1):1-13. Epub 2013 Dec 14.

Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China.

The enteric nervous system (ENS) in mammals is derived from a small pool of progenitor cells, namely enteric neural crest cells (NCCs). These precursor cells proliferate extensively to expand, migrate over a long distance to fully colonize the developing gut and differentiate into millions of neurons and glia to form a functional ENS for regulating the complex behaviors of the gut. This developmental process relies on a precise regulation of the neuronal and glial differentiation and requires an appropriate balance between the migration, proliferation and differentiation of enteric NCCs and their progeny. Read More

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October 2015
3 Reads

Depressing interleukin-1β contributed to the synergistic effects of tramadol and minocycline on spinal nerve ligation-induced neuropathic pain.

Neurosignals 2014 23;22(1):30-42. Epub 2013 Oct 23.

Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, PR China.

Our previous study indicated that coadministration of tramadol and minocycline exerted synergistic effects on spinal nerve ligation (SNL)-induced neuropathic mechanical allodynia. However, the underlying mechanisms are still unclear. Recent reports indicated that spinal proinflammatory factor interleukin-1β (IL-1β) contributed to the development of neuropathic pain and the positive feedback communication between neuron and glia. Read More

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October 2015
4 Reads

The Golgi Apparatus: Panel Point of Cytosolic Ca(2+) Regulation.

Neurosignals 2013 ;21(3-4):272-84

Department of Neurology, Second Xiangya Hospital, Central-South University, Changsha; School of Medicine, Jishou University, Jishou , PR China.

The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca(2+) store because different Ca (2+) regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca(2+) -ATPase and secretory pathway Ca 2+ -ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca(2+) release and uptake in the GA have now been established. Read More

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March 2016
7 Reads

Brain-site-specific proteome changes induced by neuronal P60TRP expression.

Neurosignals 2013 6;21(3-4):129-49. Epub 2013 Feb 6.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

p60 transcription regulator protein (p60TRP) facilitates the processing of the amyloid precursor protein towards the non-amyloidogenic pathway by inhibiting the β-secretase action. This protein was initially identified to be downregulated in the temporal lobe of brains from Alzheimer's disease patients. p60TRP is one of the G-protein-coupled receptor (GPCR)-associated proteins which directly influences the signalling capacity of GPCRs. Read More

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December 2013
2 Reads
4 Citations
2.000 Impact Factor

Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury.

Neurosignals 2012 18;20(4):237-51. Epub 2012 Jan 18.

Department of Anatomy, Li Ka Shing Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, China.

Nuclear factor of activated T cells 5 (NFAT5) has been implicated in regulating several genes that are thought to be neuroprotective in ischemic injury. Because of the embryonic lethality of NFAT5 knockout (NFAT5(-/-)) mice, the heterozygous (NFAT5(+/-)) mice were used to study the in vivo role of NFAT5 in hypoxia/ischemia (H/I) condition. The NFAT5(+/-) mice exhibited more severe neurological deficits, larger infarct area and edema formation associated with increased aquaporin 4 expressions in the brain. Read More

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April 2013
7 Reads

Dopamine inhibits high-frequency stimulation-induced long-term potentiation of intrinsic excitability in CA1 hippocampal pyramidal neurons.

Neurosignals 2013 27;21(3-4):150-9. Epub 2012 Sep 27.

Key Laboratory of MOE for Modern Teaching Technology and College of Life Sciences, Shaanxi Normal University, Xi'an, China.

The efficiency of neural circuits is modified by changes not only in synaptic strength, but also in intrinsic excitability of neurons. In CA1 hippocampal pyramidal neurons, bidirectional changes in the intrinsic excitability are often presented after induction of synaptic long-term potentiation or depression. This plasticity of intrinsic excitability has been identified as a cellular correlate of learning. Read More

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December 2013
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Functional recovery of human cells harbouring the mitochondrial DNA mutation MERRF A8344G via peptide-mediated mitochondrial delivery.

Neurosignals 2013 21;21(3-4):160-73. Epub 2012 Sep 21.

Vascular and Genomic Center, Changhua Christian Hospital, Changhua, Taiwan, ROC.

We explored the feasibility of mitochondrial therapy using the cell-penetrating peptide Pep-1 to transfer mitochondrial DNA (mtDNA) between cells and rescue a cybrid cell model of the mitochondrial disease myoclonic epilepsy with ragged-red fibres (MERRF) syndrome. Pep-1-conjugated wild-type mitochondria isolated from parent cybrid cells incorporating a mitochondria-specific tag were used as donors for mitochondrial delivery into MERRF cybrid cells (MitoB2) and mtDNA-depleted Rho-zero cells (Mitoρ°). Forty-eight hours later, translocation of Pep-1-labelled mitochondria into the mitochondrial regions of MitoB2 and Mitoρ° host cells was observed (delivery efficiencies of 77. Read More

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December 2013
9 Reads