682 results match your criteria NeuroMolecular Medicine [Journal]


Optogenetic Stimulation of the Anterior Cingulate Cortex Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation, Caudate Putamen as a Site for Alteration.

Neuromolecular Med 2019 Feb 19. Epub 2019 Feb 19.

Institute for Cognitive and Brain Science, Shahid Beheshti University, Tehran, Iran.

Epigenetic agents, such as neonatal isolation during neurodevelopmental period of life, can change various regions of the brain. It may further induce psychological disorders such as autistic-like phenomena. This study indicated the role of chronic increased anterior cingulate cortex (ACC) output on alteration of caudate putamen (CPu) as a main behavior regulator region of the brain in adult maternal deprived (MD) rats. Read More

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http://dx.doi.org/10.1007/s12017-019-08526-wDOI Listing
February 2019

The Promises and Challenges of Erythropoietin for Treatment of Alzheimer's Disease.

Neuromolecular Med 2019 Mar 17;21(1):12-24. Epub 2019 Jan 17.

Department of Biopharmaceutical Sciences, School of Pharmacy and Health Sciences, Keck Graduate Institute, 535 Watson Dr, Claremont, CA, 91711, USA.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, and intracellular neurofibrillary tangles and extracellular amyloid-beta protein deposits represent the major pathological hallmarks of the disease. Currently available treatments provide some symptomatic relief but fail to modify primary pathological processes that underlie the disease. Erythropoietin (EPO), a hematopoietic growth factor, acts primarily to stimulate erythroid cell production, and is clinically used to treat anemia. Read More

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http://dx.doi.org/10.1007/s12017-019-08524-yDOI Listing
March 2019
2 Reads

ADGRL3 rs6551665 as a Common Vulnerability Factor Underlying Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.

Neuromolecular Med 2019 Mar 16;21(1):60-67. Epub 2019 Jan 16.

Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, UFRGS, Avenida Bento Gonçalves, 9500, Porto Alegre, RS, CEP: 91501-970, Brazil.

Neurodevelopmental disorders are prevalent, frequently occur in comorbidity and share substantial genetic correlation. Previous evidence has suggested a role for the ADGRL3 gene in Attention-Deficit/Hyperactivity Disorder (ADHD) susceptibility in several samples. Considering ADGRL3 functionality in central nervous system development and its previous association with neurodevelopmental disorders, we aimed to assess ADGRL3 influence in early-onset ADHD (before 7 years of age) and Autism Spectrum Disorder (ASD). Read More

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http://dx.doi.org/10.1007/s12017-019-08525-xDOI Listing
March 2019
3 Reads

Tinospora cordifolia Suppresses Neuroinflammation in Parkinsonian Mouse Model.

Neuromolecular Med 2019 Mar 14;21(1):42-53. Epub 2019 Jan 14.

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.

Parkinson's disease (PD), a neurodegenerative central nervous system disorder, is characterised by progressive loss of nigrostriatal neurons in basal ganglia. Previous studies regarding PD have suggested the role of oxidative stress along with neuroinflammation in neurodegeneration. Accordingly, our study explore the anti-inflammatory activity of Tinospora cordifolia aqueous extract (TCAE) in 1-methyl-4-phenyl-1,2,3,6-tetra hydropyridine (MPTP)-intoxicated Parkinsonian mouse model. Read More

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http://link.springer.com/10.1007/s12017-018-08521-7
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http://dx.doi.org/10.1007/s12017-018-08521-7DOI Listing
March 2019
4 Reads

Therapeutic Approaches to Alzheimer's Disease Through Modulation of NRF2.

Neuromolecular Med 2019 Mar 7;21(1):1-11. Epub 2019 Jan 7.

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/NRF2) is a master transcription factor that regulates oxidative stress-related genes containing the antioxidant response element (ARE) in their promoters. The damaged function and altered localization of NRF2 are found in most neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis. These neurodegenerative diseases developed from various risk factors such as accumulated oxidative stress and genetic and environmental elements. Read More

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http://dx.doi.org/10.1007/s12017-018-08523-5DOI Listing
March 2019
3 Reads

A Novel and Mosaic WDR45 Nonsense Variant Causes Beta-Propeller Protein-Associated Neurodegeneration Identified Through Whole Exome Sequencing and X chromosome Heterozygosity Analysis.

Neuromolecular Med 2019 Mar 5;21(1):54-59. Epub 2019 Jan 5.

Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Çapa/istanbul, 34093, Turkey.

Beta-propeller protein-associated neurodegeneration (BPAN) is an X-linked rare dominant disorder of autophagy. The role of WDR45 has been implicated in BPAN almost exclusively in females possibly due to male lethality. Characterization of distinctive clinical manifestations and potentially the complex genetic determinants in rare male patients remain crucial for deciphering BPAN and other X-linked dominant diseases. Read More

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http://link.springer.com/10.1007/s12017-018-08522-6
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http://dx.doi.org/10.1007/s12017-018-08522-6DOI Listing
March 2019
2 Reads

Hsc70 Interacts with β4GalT5 to Regulate the Growth of Gliomas.

Neuromolecular Med 2019 Mar 3;21(1):33-41. Epub 2019 Jan 3.

Department of Neurosurgery, Yancheng City No. 1 People's Hospital, The Fourth Affiliated Hospital of Nantong University, Yancheng, 224001, People's Republic of China.

Heat shock cognate protein 70 (Hsc70) is a key mediator for the maintenance of intracellular proteins and regulates cellular activities. And it is elevated in various tumor tissues including glioma, which is closely related to the malignancy and poor prognosis of the tumors. However, the effects of Hsc70 on gliomas and its regulatory mechanism have not yet been elucidated. Read More

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http://link.springer.com/10.1007/s12017-018-08520-8
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http://dx.doi.org/10.1007/s12017-018-08520-8DOI Listing
March 2019
5 Reads

The Emerging Roles of Ferroptosis in Huntington's Disease.

Neuromolecular Med 2019 Jan 2. Epub 2019 Jan 2.

Shaanxi Key Laboratory of Brain Disorders, and Department of Basic Medicine, Xi'an Medical University, Xi'an, 710021, China.

Huntington's disease (HD) is an autosomal dominant and fatal neurodegenerative disorder, which is caused by an abnormal CAG repeat in the huntingtin gene. Despite its well-defined genetic origin, the molecular mechanisms of neuronal death are unclear yet, thus there are no effective strategies to block or postpone the process of HD. Ferroptosis, a recently identified iron-dependent cell death, attracts considerable attention due to its putative involvement in neurodegenerative diseases. Read More

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http://dx.doi.org/10.1007/s12017-018-8518-6DOI Listing
January 2019
3.678 Impact Factor

BDNF rs6265 (Val66Met) Polymorphism as a Risk Factor for Blepharospasm.

Neuromolecular Med 2019 Mar 5;21(1):68-74. Epub 2018 Dec 5.

Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.

A few genetic variants are implicated in the development of blepharospasm (BSP). The precise role of the rs6265 on the brain-derived neurotrophic factor (BDNF) gene on BSP remains controversial. The effect of rs6265 on BSP was evaluated. Read More

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http://dx.doi.org/10.1007/s12017-018-8519-5DOI Listing
March 2019
52 Reads

AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression.

Neuromolecular Med 2019 Mar 8;21(1):25-32. Epub 2018 Nov 8.

National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

Parkinson's disease (PD) is a prevalent neurodegenerative movement disorder that is characterized pathologically by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, the etiology of PD remains poorly understood. Interestingly, recent studies have implicated neuronal energy dysregulation as one of the key perpetrators of the disease. Read More

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http://link.springer.com/10.1007/s12017-018-8517-7
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http://dx.doi.org/10.1007/s12017-018-8517-7DOI Listing
March 2019
10 Reads

CSF Aβ, but not p-Tau, Predicted Progression from Amnestic MCI to Alzheimer's Disease Dementia.

Neuromolecular Med 2018 12 10;20(4):491-497. Epub 2018 Oct 10.

Division of Geriatric Neurology, Neurology Service, Hospital de Clínicas de Porto Alegre (HCPA), Ramiro Barcelos Street, 2350, Porto Alegre, 90035-903, RS, Brazil.

The purpose of the study was to determine whether Aβ and p-Tau cerebral spinal fluid (CSF) levels can predict progression from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease dementia (ADD) in a 3-year follow-up study. All participants were evaluated blindly by a behavioral neurologist and a neuropsychologist, and classified according to the Petersen criteria for aMCI and according to the Clinical Dementia Rating (CDR) scale. Individuals were also submitted to lumbar puncture at baseline. Read More

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http://dx.doi.org/10.1007/s12017-018-8516-8DOI Listing
December 2018
2 Reads

The Toll Pathway in the Central Nervous System of Flies and Mammals.

Neuromolecular Med 2018 12 1;20(4):419-436. Epub 2018 Oct 1.

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

Toll receptors, first identified to regulate embryogenesis and immune responses in the adult fly and subsequently defined as the principal sensors of infection in mammals, are increasingly appreciated for their impact on the homeostasis of the central as well as the peripheral nervous systems. Whereas in the context of immunity, the fly Toll and the mammalian TLR pathways have been researched in parallel, the expression pattern and functionality have largely been researched disparately. Herein, we provide data on the expression pattern of the Toll homologues, signaling components, and downstream effectors in ten different cell populations of the adult fly central nervous system (CNS). Read More

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http://dx.doi.org/10.1007/s12017-018-8515-9DOI Listing
December 2018

Contribution of the Wnt Pathway to Defining Biology of Glioblastoma.

Neuromolecular Med 2018 12 26;20(4):437-451. Epub 2018 Sep 26.

Graduate School of Clinical Neurosciences, University of Pecs, Pecs, Hungary.

Glioblastoma (GBM), a highly lethal brain tumor, has been comprehensively characterized at the molecular level with the identification of several potential treatment targets. Data concerning the Wnt pathway are relatively sparse, but apparently very important in defining several aspects of tumor biology. The Wnt ligands are involved in numerous basic biological processes including regulation of embryogenic development, cell fate determination, and organogenesis, but growing amount of data also support the roles of Wnt pathways in the formation of many tumors, including gliomas. Read More

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http://link.springer.com/10.1007/s12017-018-8514-x
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http://dx.doi.org/10.1007/s12017-018-8514-xDOI Listing
December 2018
12 Reads

Plasma β-Amyloids and Tau Proteins in Patients with Vascular Cognitive Impairment.

Neuromolecular Med 2018 12 21;20(4):498-503. Epub 2018 Sep 21.

Department of Neurology, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei, 100, Taiwan.

Increases in plasma of β-amyloids (Aβ) and tau proteins have been noted in patients with Alzheimer's dementia (AD). Our study investigated the associations of plasma Aβ and tau proteins with dementia in stroke patients. This cross-sectional study recruited 24 controls (mean age: 67. Read More

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http://dx.doi.org/10.1007/s12017-018-8513-yDOI Listing
December 2018
2 Reads

Metabolism of Docosahexaenoic Acid (DHA) Induces Pyroptosis in BV-2 Microglial Cells.

Neuromolecular Med 2018 12 19;20(4):504-514. Epub 2018 Sep 19.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.

DHA is one of the most abundant fatty acids in the brain, largely present in stores of membrane phospholipids. It is readily released by the action of phospholipase A2 and is known to induce anti-inflammatory and neurotrophic effects. It is not thought to contribute to proinflammatory processes in the brain. Read More

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http://dx.doi.org/10.1007/s12017-018-8511-0DOI Listing
December 2018

The FOXP3 rs3761547 Gene Polymorphism in Multiple Sclerosis as a Male-Specific Risk Factor.

Neuromolecular Med 2018 12 18;20(4):537-543. Epub 2018 Sep 18.

Department of Neurology, Medical University of Bialystok, Białystok, Poland.

The FOXP3 gene encodes a transcription factor and is predominantly expressed in the CD4CD25 regulatory T cells which plays a pivotal role in the maintenance of immune homeostasis. The defect of FOXP3 gene may provide a critical link between autoimmunity and immune deficiency. The purpose of our study was to evaluate the association of chosen polymorphisms of FOXP3 gene (rs3761549, rs3761548, rs3761547) with different clinical multiple sclerosis (MS) data of our relapsing-remitting groups of patients and in control group. Read More

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http://dx.doi.org/10.1007/s12017-018-8512-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244921PMC
December 2018
2 Reads

Central Orexin A Affects Reproductive Axis by Modulation of Hypothalamic Kisspeptin/Neurokinin B/Dynorphin Secreting Neurons in the Male Wistar Rats.

Neuromolecular Med 2018 Dec 14;20(4):525-536. Epub 2018 Sep 14.

Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

It is an established fact that orexin plays an important role in regulating the reproductive axis and the secretions of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH). However, its precise cellular and molecular mechanisms are not fully recognized. Accordingly, the aim of the present study is to find out whether the central injection of orexin A (OXA) and its antagonists, SB-334867 (as orexin receptor antagonist 1; OX1RA) and JNJ-10397049 (as orexin receptor antagonist 2; OX2RA), either alone or in combination, can leave any impact on the reproductive axis (either hormonal or behavioral) in the male Wistar rats. Read More

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http://dx.doi.org/10.1007/s12017-018-8506-xDOI Listing
December 2018

Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and Form Aggregates in the Nucleus.

Neuromolecular Med 2019 Mar 10;21(1):85-96. Epub 2018 Sep 10.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, College of Life Sciences, Beijing Normal University, Beijing, China.

Human tetratricopeptide repeat domain 3 (TTC3) is a gene on 21q22.2 within the Down syndrome critical region (DSCR). Earlier studies suggest that TTC3 may be an important regulator in individual development, especially in neural development. Read More

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http://dx.doi.org/10.1007/s12017-018-8509-7DOI Listing
March 2019
1 Read
3.680 Impact Factor

Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma.

Neuromolecular Med 2018 12 4;20(4):452-474. Epub 2018 Sep 4.

Department of Radiation Oncology, Tianjin Hospital, Tianjin, 300211, China.

GBM is the highest incidence in primary intracranial malignancy, and it remains poor prognosis even though the patient is gave standard treatment. Despite decades of intense research, the complex biology of GBM remains elusive. In view of eight hallmarks of cancer which were proposed in 2011, studies related to the eight biological capabilities in GBM have made great progress. Read More

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http://dx.doi.org/10.1007/s12017-018-8507-9DOI Listing
December 2018
3 Reads

Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic-Ischemic Encephalopathy.

Neuromolecular Med 2019 Mar 3;21(1):75-84. Epub 2018 Sep 3.

Institute of Biomedical Science and Children's Hospital, Fudan University, Shanghai, 201102, China.

Cerebral palsy (CP) is a leading cause of neurological disability among young children. Congenial and adverse perinatal clinical conditions, such as genetic factors, perinatal infection, and asphyxia, are risk factors for CP. Oligodendrocyte transcription factor (OLIG2) is a protein that is expressed in brain oligodendrocyte cells and is involved in neuron repair after brain injury. Read More

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http://dx.doi.org/10.1007/s12017-018-8510-1DOI Listing
March 2019
11 Reads

Overexpression of Human Mutant PANK2 Proteins Affects Development and Motor Behavior of Zebrafish Embryos.

Neuromolecular Med 2018 Aug 23. Epub 2018 Aug 23.

Department of Molecular and Translational Medicine, University of Brescia, viale Europa 11, 25123, Brescia, Italy.

Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a genetic and early-onset neurodegenerative disorder characterized by iron accumulation in the basal ganglia. It is due to mutations in Pantothenate Kinase 2 (PANK2), an enzyme that catalyzes the phosphorylation of vitamin B5, first and essential step in coenzyme A (CoA) biosynthesis. Most likely, an unbalance of the neuronal levels of this important cofactor represents the initial trigger of the neurodegenerative process, yet a complete understanding of the connection between PANK2 malfunctioning and neuronal death is lacking. Read More

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http://link.springer.com/10.1007/s12017-018-8508-8
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http://dx.doi.org/10.1007/s12017-018-8508-8DOI Listing
August 2018
11 Reads

Neuroprotective Effect of Hydrogen Sulfide in Hyperhomocysteinemia Is Mediated Through Antioxidant Action Involving Nrf2.

Neuromolecular Med 2018 12 13;20(4):475-490. Epub 2018 Aug 13.

Department of Biochemistry, Basic Medical Science Block-II, Sector-25, Panjab University, Chandigarh, 160014, India.

Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism. Elevated plasma Hcy levels (> 15 µM) result in a condition called hyperhomocysteinemia (HHcy), which is an independent risk factor in the development of various neurodegenerative disorders. Reactive oxygen species (ROS) produced by auto-oxidation of Hcy have been implicated in HHcy-associated neurological conditions. Read More

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http://link.springer.com/10.1007/s12017-018-8505-y
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http://dx.doi.org/10.1007/s12017-018-8505-yDOI Listing
December 2018
16 Reads

DRD3 Gene and ADHD: A Pharmaco-Behavioural Genetic Study.

Neuromolecular Med 2018 12 26;20(4):515-524. Epub 2018 Jul 26.

Douglas Mental Health University Institute, Montreal, QC, Canada.

Results of candidate gene investigations in ADHD have been difficult to replicate. The complexity of the phenotypes and their underlying determinants, and the relatively small effect sizes of genetic variants may, in part, be contributing to these inconsistencies. The objective of this study is to conduct an exploratory analysis using a comprehensive approach to investigate the role of candidate genes. Read More

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http://dx.doi.org/10.1007/s12017-018-8504-zDOI Listing
December 2018

Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons.

Neuromolecular Med 2018 09 18;20(3):281-300. Epub 2018 Jul 18.

Technical University of Sofia, Klement Ohridksi 8, 1000, Sofia, Bulgaria.

The astrocyte-neuron lactate shunt (ANLS) hypothesis is the most widely accepted model of brain glucose metabolism. However, over the past decades, research has shown that neuronal and astrocyte plasma membrane receptors, in particular, GLUT2, Kir6.2 subunit of the potassium ATP-channel, SGLT-3 acting as glucosensors, play a pivotal role in brain glucose metabolism. Read More

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http://dx.doi.org/10.1007/s12017-018-8503-0DOI Listing
September 2018
1 Read

RNA Sequencing and Pathway Analysis Identify Important Pathways Involved in Hypertrichosis and Intellectual Disability in Patients with Wiedemann-Steiner Syndrome.

Neuromolecular Med 2018 09 16;20(3):409-417. Epub 2018 Jul 16.

Inserm, U1016, Institut Cochin, Paris, France.

A growing number of histone modifiers are involved in human neurodevelopmental disorders, suggesting that proper regulation of chromatin state is essential for the development of the central nervous system. Among them, heterozygous de novo variants in KMT2A, a gene coding for histone methyltransferase, have been associated with Wiedemann-Steiner syndrome (WSS), a rare developmental disorder mainly characterized by intellectual disability (ID) and hypertrichosis. As KMT2A is known to regulate the expression of multiple target genes through methylation of lysine 4 of histone 3 (H3K4me), we sought to investigate the transcriptomic consequences of KMT2A variants involved in WSS. Read More

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http://dx.doi.org/10.1007/s12017-018-8502-1DOI Listing
September 2018
13 Reads

Potential Role of Brain-Derived Neurotrophic Factor and Dopamine Receptor D2 Gene Variants as Modifiers for the Susceptibility and Clinical Course of Wilson's Disease.

Neuromolecular Med 2018 Sep 10;20(3):401-408. Epub 2018 Jul 10.

S. N. Pradhan Centre for Neurosciences, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.

Wilson's disease (WD), an inborn error of copper metabolism caused by mutations in the ATPase copper transporting beta (ATP7B) gene, manifests variable age of onset and different degrees of hepatic and neurological disturbances. This complex phenotypical outcome of a classical monogenic disease can possibly be explained by modifier loci regulating the clinical course of the disease. The brain-derived neurotropic factor (BDNF), critical for the survival, morphogenesis, and plasticity of the neurons, and the dopamine receptor D2 (DRD2), one of the most abundant dopamine receptors in the brain, have been highlighted in the pathophysiology of various neuropsychiatric diseases. Read More

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http://dx.doi.org/10.1007/s12017-018-8501-2DOI Listing
September 2018
5 Reads

Cerebrospinal Fluid C-Reactive Protein in Parkinson's Disease: Associations with Motor and Non-motor Symptoms.

Neuromolecular Med 2018 09 6;20(3):376-385. Epub 2018 Jul 6.

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Parkinson' disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non-motor symptoms of PD. One of the most notable inflammatory proteins is C-reactive protein (CRP), which is elevated in the conditions of systemic inflammation. Read More

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http://dx.doi.org/10.1007/s12017-018-8499-5DOI Listing
September 2018
6 Reads

Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway.

Neuromolecular Med 2018 09 3;20(3):386-400. Epub 2018 Jul 3.

Department of Physiology, School of Medicine, Selçuk University, Konya, 42131, Turkey.

This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. Read More

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http://dx.doi.org/10.1007/s12017-018-8500-3DOI Listing
September 2018
9 Reads

The Transcriptional Regulatory Properties of Amyloid Beta 1-42 may Include Regulation of Genes Related to Neurodegeneration.

Neuromolecular Med 2018 09 12;20(3):363-375. Epub 2018 Jun 12.

Brain and Neurodegenerative Disorders Research Laboratory, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, 34098, Istanbul, Turkey.

Our previous study demonstrated the translocation of Aβ1-42 to the nucleus in response to antibiotic treatment, and interpreted it as a possible transcriptional response of Aβ1-42 to antibiotics. The present study aims to investigate how amyloid acts on the key elements of neurodegeneration and the molecules involved in the induction of Aβ1-42 production. For this purpose, we investigated the acute effect of Aβ1-42 on the transcriptional levels of genes that have roles in the mechanisms that produce Aβ itself: alpha secretase (ADAM10), beta secretase (BACE1), the gamma secretase complex (PS-1, PS-2, Nicastrin), the substrate APP, APOE (the significant risk factor for sporadic form of the AD), TREM2 (recently indicated as a contributor to AD risk), NMDAR subunits and PKCzeta (contributors of memory and learning), and key elements of tau pathology such as tau, GSK3α, GSK3β, and Cdk5. Read More

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http://dx.doi.org/10.1007/s12017-018-8498-6DOI Listing
September 2018
5 Reads

Effects of Low Phytanic Acid-Concentrated DHA on Activated Microglial Cells: Comparison with a Standard Phytanic Acid-Concentrated DHA.

Neuromolecular Med 2018 09 30;20(3):328-342. Epub 2018 May 30.

Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain.

Docosahexaenoic acid (DHA, 22:6 n-3) is an essential omega-3 (ω-3) long chain polyunsaturated fatty acid of neuronal membranes involved in normal growth, development, and function. DHA has been proposed to reduce deleterious effects in neurodegenerative processes. Even though, some inconsistencies in findings from clinical and pre-clinical studies with DHA could be attributed to the presence of phytanic acid (PhA) in standard DHA treatments. Read More

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http://link.springer.com/10.1007/s12017-018-8496-8
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http://dx.doi.org/10.1007/s12017-018-8496-8DOI Listing
September 2018
7 Reads

Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation.

Neuromolecular Med 2018 09 30;20(3):343-362. Epub 2018 May 30.

Medical Biotechnology Laboratory, Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

Reactive gliosis, microgliosis, and subsequent secretion of various inflammatory mediators like cytokines, proteases, reactive oxygen, and nitrogen species are the suggested key players associated with systemic inflammation-driven neuroinflammation and cognitive impairments in various neurological disorders. Conventionally, non-steroidal anti-inflammatory drugs are prescribed to suppress inflammation but due to their adverse effects, their usage is not well accepted. Natural products are emerging better therapeutic agents due to their affordability and inherent pleiotropic biological activities. Read More

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http://dx.doi.org/10.1007/s12017-018-8497-7DOI Listing
September 2018
17 Reads

Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway.

Neuromolecular Med 2018 09 25;20(3):312-327. Epub 2018 May 25.

College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk, 28160, Republic of Korea.

Amyloidogenesis is known to cause Alzheimer's disease. Our previous studies have found that lipopolysaccharide (LPS) causes neuroinflammation and amyloidogenesis through activation of nuclear factor kappaB (NF-κB). Piperlongumine (PL) is an alkaloid amide found naturally in long pepper (Piper longum) isolates; it was reported to have inhibitory effects on NF-κB activity. Read More

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http://dx.doi.org/10.1007/s12017-018-8495-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097046PMC
September 2018
7 Reads
3.680 Impact Factor

CD271+, CXCR7+, CXCR4+, and CD133+ Stem/Progenitor Cells and Clinical Characteristics of Acute Ischemic Stroke Patients.

Neuromolecular Med 2018 Sep 9;20(3):301-311. Epub 2018 May 9.

Department of Adult Neurology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-211, Gdańsk, Poland.

Ischemic stroke causes mobilization of various groups of progenitor cells from bone marrow to bloodstream and this correlates with the neurological status of stroke patients. The goal of our study was to identify the activity of chosen progenitor/stem cells in the peripheral blood of acute ischemic stroke patients in the first 7 days after the incident, through associations between the levels of the cells and clinical features of the patients. Thirty-three acute ischemic stroke patients and 15 non-stroke control subjects had their venous blood collected repeatedly in order to assess the levels of the CD45-CD34 + CD271+, the CD45-CD34 + CXCR4+, the CD45-CD34 + CXCR7+, and the CD45-CD34 + CD133+ stem/progenitor cells by means of flow cytometry. Read More

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http://dx.doi.org/10.1007/s12017-018-8494-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097064PMC
September 2018
3 Reads

The Dynamics of Neurosteroids and Sex-Related Hormones in the Pathogenesis of Alzheimer's Disease.

Neuromolecular Med 2018 Jun 4;20(2):215-224. Epub 2018 May 4.

Stem Cell Research Center, Tabriz University of Medical Sciences, Imam Reza St., Golgasht St., Tabriz, Iran.

Alzheimer's disease (AD) is commonly diagnosed by vast extracellular amyloid deposits and existence of intracellular neurofibrillary tangles. In accordance with the literature, age-related loss of sex steroid hormones in either males or females was found in relation to AD subjects. The dynamics of these hormones have been previously described in both physiological and pathological conditions with the evidence of changes in various intracellular signalings regarding the neurodegenerative disease. Read More

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http://dx.doi.org/10.1007/s12017-018-8493-yDOI Listing
June 2018
3 Reads
3.680 Impact Factor

Association of CALM1 rs3179089 Polymorphism with Ischemic Stroke in Chinese Han Population.

Neuromolecular Med 2018 06 30;20(2):271-279. Epub 2018 Apr 30.

School of Public Health of Guangxi Medical University, Nanning, Guangxi, China.

A quantitative transcriptomics analysis has reported that Calmodulin 1 (CALM1) is highly expressed in human brain tissues. This study aims to evaluate the relationship between CALM1 rs3179089 polymorphism and ischemic stroke (IS) in Chinese Han population. A total of 550 patients with IS and 550 control subjects were recruited and genotyped using Sequenom MassArray technology. Read More

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http://link.springer.com/10.1007/s12017-018-8492-z
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http://dx.doi.org/10.1007/s12017-018-8492-zDOI Listing
June 2018
4 Reads

BDNF/TrkB Pathway Mediates the Antidepressant-Like Role of HS in CUMS-Exposed Rats by Inhibition of Hippocampal ER Stress.

Neuromolecular Med 2018 06 27;20(2):252-261. Epub 2018 Apr 27.

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, University of South China, 28 West Changsheng Road, Hengyang, 421001, Hunan, People's Republic of China.

Our previous works have shown that hydrogen sulfide (HS) significantly attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors and hippocampal endoplasmic reticulum (ER) stress. Brain-derived neurotrophic factor (BDNF) generates an antidepressant-like effect by its receptor tyrosine protein kinase B (TrkB). We have previously found that HS upregulates the expressions of BDNF and p-TrkB in the hippocampus of CUMS-exposed rats. Read More

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http://dx.doi.org/10.1007/s12017-018-8489-7DOI Listing
June 2018
8 Reads

Improved Bioavailability of Levodopa Using Floatable Spray-Coated Microcapsules for the Management of Parkinson's Disease.

Neuromolecular Med 2018 06 25;20(2):262-270. Epub 2018 Apr 25.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Oral administration of levodopa (LD) is the gold standard in managing Parkinson's disease (PD). Although LD is the most effective drug in treating PD, chronic administration of LD induces levodopa-induced dyskinesia. A continuous and sustained provision of LD to the brain could, therefore, reduce peak-dose dyskinesia. Read More

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http://dx.doi.org/10.1007/s12017-018-8491-0DOI Listing
June 2018
8 Reads

How to Spot Congenital Myasthenic Syndromes Resembling the Lambert-Eaton Myasthenic Syndrome? A Brief Review of Clinical, Electrophysiological, and Genetics Features.

Neuromolecular Med 2018 06 25;20(2):205-214. Epub 2018 Apr 25.

Department of Neuropediatrics and Muscle Disorders, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Congenital myasthenic syndromes (CMS) are heterogeneous genetic diseases in which neuromuscular transmission is compromised. CMS resembling the Lambert-Eaton myasthenic syndrome (CMS-LEMS) are emerging as a rare group of distinct presynaptic CMS that share the same electrophysiological features. They have low compound muscular action potential amplitude that increment after brief exercise (facilitation) or high-frequency repetitive nerve stimulation. Read More

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http://link.springer.com/10.1007/s12017-018-8490-1
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http://dx.doi.org/10.1007/s12017-018-8490-1DOI Listing
June 2018
20 Reads

Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation.

Neuromolecular Med 2018 06 24;20(2):161-173. Epub 2018 Apr 24.

Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA.

Autism spectrum disorders (ASD) are the most prevalent set of pediatric neurobiological disorders. The etiology of ASD has both genetic and environmental components including possible dysfunction of the immune system. The relationship of the immune system to aberrant neural circuitry output in the form of altered behaviors and communication characterized by ASD is unknown. Read More

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http://dx.doi.org/10.1007/s12017-018-8488-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942347PMC
June 2018
8 Reads

Secretome of Differentiated PC12 Cells Restores the Monocrotophos-Induced Damages in Human Mesenchymal Stem Cells and SHSY-5Y Cells: Role of Autophagy and Mitochondrial Dynamics.

Neuromolecular Med 2018 06 30;20(2):233-251. Epub 2018 Mar 30.

System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.

A perturbed cellular homeostasis is a key factor associated with xenobiotic exposure resulting in various ailments. The local cellular microenvironment enriched with secretory components aids in cell-cell communication that restores this homeostasis. Deciphering the underlying mechanism behind this restorative potential of secretome could serve as a possible solution to many health hazards. Read More

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http://dx.doi.org/10.1007/s12017-018-8487-9DOI Listing
June 2018
7 Reads

Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway-PPAR Gamma, Energy Metabolism and Circadian Rhythms.

Neuromolecular Med 2018 06 23;20(2):174-204. Epub 2018 Mar 23.

DRCI, Hôpital Foch, Suresnes, France.

Entropy production rate is increased by several metabolic and thermodynamics abnormalities in neurodegenerative diseases (NDs). Irreversible processes are quantified by changes in the entropy production rate. This review is focused on the opposing interactions observed in NDs between the canonical WNT/beta-catenin pathway and PPAR gamma and their metabolic and thermodynamic implications. Read More

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http://dx.doi.org/10.1007/s12017-018-8486-xDOI Listing
June 2018
4 Reads

GWAS-Supported CRP Gene Polymorphisms and Functional Outcome of Large Artery Atherosclerotic Stroke in Han Chinese.

Neuromolecular Med 2018 06 19;20(2):225-232. Epub 2018 Mar 19.

Department of Neurology, Jinling Hospital, Southern Medical University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China.

Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with first-ever LAA IS were prospectively enrolled in Nanjing Stroke Registry Program between August 2013 and October 2015. Read More

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http://dx.doi.org/10.1007/s12017-018-8485-yDOI Listing
June 2018
4 Reads

Vitamin D Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke.

Neuromolecular Med 2018 03 23;20(1):147-159. Epub 2018 Feb 23.

Vascular Biology Immunopharmacology Group, Department of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, 3083, Australia.

Acute inflammation can exacerbate brain injury after ischemic stroke. Beyond its well-characterized role in calcium metabolism, it is becoming increasingly appreciated that the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25-VitD), has potent immunomodulatory properties. Here, we aimed to determine whether 1,25-VitD supplementation could reduce subsequent brain injury and associated inflammation after ischemic stroke. Read More

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http://link.springer.com/10.1007/s12017-018-8484-z
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http://dx.doi.org/10.1007/s12017-018-8484-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834596PMC
March 2018
8 Reads

Resveratrol Improves Neuroimmune Dysregulation Through the Inhibition of Neuronal Toll-Like Receptors and COX-2 Signaling in BTBR T Itpr3/J Mice.

Neuromolecular Med 2018 03 21;20(1):133-146. Epub 2018 Feb 21.

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Autism is a neurodevelopmental disorder characterized by deficits in qualitative impairments in communication, repetitive and social interaction, restricted, and stereotyped patterns of behavior. Resveratrol has been extensively studied pharmacologically and biologically and has anti-inflammatory, antioxidant, and neuroprotective effects on neuronal damage in neurodegenerative disorders. The BTBR T Itpr3/J (BTBR) autistic mouse model has been explored for treatment of autism, which shows low reciprocal social interactions, impaired juvenile play, and decreased social approach. Read More

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http://dx.doi.org/10.1007/s12017-018-8483-0DOI Listing
March 2018
10 Reads

Differential Binding of Human ApoE Isoforms to Insulin Receptor is Associated with Aberrant Insulin Signaling in AD Brain Samples.

Neuromolecular Med 2018 03 15;20(1):124-132. Epub 2018 Feb 15.

Departments of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.

Apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD), where inheritance of this isoform predisposes development of AD in a gene dose-dependent manner. Although the mode of action of ApoE4 on AD onset and progression remains unknown, we have previously shown that ApoE4, and not ApoE3 expression, resulted in insulin signaling deficits in the presence of amyloid beta (Aβ). However, these reports were not conducted with clinical samples that more accurately reflect human disease. Read More

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http://dx.doi.org/10.1007/s12017-018-8480-3DOI Listing
March 2018
2 Reads

Correction of Huntington's Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model.

Neuromolecular Med 2018 03 12;20(1):112-123. Epub 2018 Feb 12.

Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.

Huntington's disease (HD) is a monogenic disorder, caused by mutations in the HTT gene which result in expansion of CAG triplets. The product of the mutated gene is misfolded huntingtin protein that forms aggregates leading to impairment of neuronal function, neurodegeneration, motor abnormalities and cognitive deficits. No effective cure is currently available for HD. Read More

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http://dx.doi.org/10.1007/s12017-018-8482-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834590PMC
March 2018
3 Reads

Cardiovascular Autonomic Dysfunction: Link Between Multiple Sclerosis Osteoporosis and Neurodegeneration.

Authors:
Zohara Sternberg

Neuromolecular Med 2018 03 10;20(1):37-53. Epub 2018 Feb 10.

Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 100 High Street, Buffalo, NY, 14203-1126, USA.

The high prevalence of osteoporosis, observed in multiple sclerosis (MS) patients, has been attributed to reduced mobility and or the use of disease-modifying drugs. However, MS-impaired cardiovascular autonomic nervous system (ANS) function has the potential of reducing bone mass density (BMD) by altering the expression and/or function of the neuronal, systemic, and local mediators of bone remodeling. This review describes the complex regulation of bone homeostasis with a focus on MS, providing evidence that ANS dysfunction and low BMD are intertwined with MS inflammatory and neurodegenerative processes, and with other MS-related morbidities, including depression, fatigue, and migraine. Read More

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http://dx.doi.org/10.1007/s12017-018-8481-2DOI Listing
March 2018
3 Reads

Molecular Insights into the Roles of Rab Proteins in Intracellular Dynamics and Neurodegenerative Diseases.

Neuromolecular Med 2018 03 8;20(1):18-36. Epub 2018 Feb 8.

Field Neurosciences Institute Laboratory for Restorative Neurology, Program in Neuroscience, Department of Psychology, Central Michigan University, Mt. Pleasant, MI, 48859, USA.

In eukaryotes, the cellular functions are segregated to membrane-bound organelles. This inherently requires sorting of metabolites to membrane-limited locations. Sorting the metabolites from ribosomes to various organelles along the intracellular trafficking pathways involves several integral cellular processes, including an energy-dependent step, in which the sorting of metabolites between organelles is catalyzed by membrane-anchoring protein Rab-GTPases (Rab). Read More

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http://dx.doi.org/10.1007/s12017-018-8479-9DOI Listing
March 2018
4 Reads

Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy.

Neuromolecular Med 2018 03 6;20(1):97-111. Epub 2018 Feb 6.

Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, 510632, China.

Our previous studies demonstrated that the multifunctional agent TBN, a derivative of tetramethylpyrazine armed with a nitrone moiety, displayed high therapeutic efficacy in experimental ischemic stroke models. However, its molecular mechanisms of action underlying the neuroprotective effect need further exploration. In the present study, we found that TBN had significant activities scavenging free radicals such as OH, O and ONOO, inhibiting Ca overload, maintaining mitochondrial function and preventing neuronal damage in primary cortical cultures. Read More

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http://dx.doi.org/10.1007/s12017-018-8478-xDOI Listing
March 2018
13 Reads

NMDA Receptor GluN2 Subtypes Control Epileptiform Events in the Hippocampus.

Neuromolecular Med 2018 03 15;20(1):90-96. Epub 2018 Jan 15.

Molecular Medicine, Applied Biology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, 695012, India.

NMDA receptors (NMDARs) play a key role in synaptic plasticity and excitotoxicity. Subtype-specific role of NMDAR in neural disorders is an emerging area. Recent studies have revealed that mutations in NMDARs are a cause for epilepsy. Read More

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http://dx.doi.org/10.1007/s12017-018-8477-yDOI Listing
March 2018
6 Reads