692 results match your criteria NeuroMolecular Medicine [Journal]


Hydrogen Sulfide Inhibits Formaldehyde-Induced Senescence in HT-22 Cells via Upregulation of Leptin Signaling.

Neuromolecular Med 2019 Apr 12. Epub 2019 Apr 12.

Institute of Neuroscience, Hengyang Medical College, University of South China, 28 W Changsheng Road, Hengyang, 42100, Hunan, People's Republic of China.

It has been previously demonstrated that hydrogen sulfide (HS) prevents formaldehyde (FA)-induced neurotoxicity. However, the exact mechanisms underlying this protection remain to be fully elucidated. Neuronal senescence is involved in FA-induced neurotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08536-8DOI Listing
April 2019
4 Reads

MiR-34 and MiR-200: Regulator of Cell Fate Plasticity and Neural Development.

Neuromolecular Med 2019 Apr 8. Epub 2019 Apr 8.

Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, UP, 226001, India.

Studies from last two decades have established microRNAs (miRNAs) as the most influential regulator of gene expression, especially at the post-transcriptional stage. The family of small RNA molecules including miRNAs is highly conserved and expressed throughout the multicellular organism. MiRNAs regulate gene expression by binding to 3' UTR of protein-coding mRNAs and initiating either decay or movement of mRNAs to stress granules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08535-9DOI Listing

A Novel Variant (Asn177Asp) in SPTLC2 Causing Hereditary Sensory Autonomic Neuropathy Type 1C.

Neuromolecular Med 2019 Apr 6. Epub 2019 Apr 6.

Institute for Clinical Chemistry, University Hospital Zurich, University of Zurich, Wagistrasse 14 Schlieren, 8952, Zurich, Switzerland.

Hereditary sensory and autonomic neuropathy type 1 (HSAN1) is a rare, autosomal dominantly inherited, slowly progressive and length-dependent axonal peripheral neuropathy. HSAN1 is associated with several mutations in serine-palmitoyltransferase (SPT), the first enzyme in the de novo sphingolipid biosynthetic pathway. HSAN1 mutations alter the substrate specificity of SPT, which leads to the formation of 1-deoxysphingolipids, an atypical and neurotoxic subclass of sphingolipids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08534-wDOI Listing

A Short Bout of Exercise Prior to Stroke Improves Functional Outcomes by Enhancing Angiogenesis.

Neuromolecular Med 2019 Apr 2. Epub 2019 Apr 2.

Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.

Stroke remains a significant unmet clinical need with limited therapeutic options. The peculiar feature of ischemic stroke is the interruption in brain circulation, resulting in a cascade of detrimental cerebrovasculature alterations. Treatment strategies designed to maintain potency of the cerebrovasculature may protect against stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08533-xDOI Listing
April 2019
4 Reads

The Neuronal Ceroid Lipofuscinoses-Linked Loss of Function CLN5 and CLN8 Variants Disrupt Normal Lysosomal Function.

Neuromolecular Med 2019 Mar 27. Epub 2019 Mar 27.

Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Neuronal ceroid lipofuscinoses (NCLs) are a group of neurodegenerative disorders caused by mutations in fourteen distinct ceroid lipofuscinoses, neuronal (CLN) genes described with various severe symptoms such as seizures, visual failure, motor decline, and progressive cognitive deterioration. The current research represents novel CLN5 (c.741G > A) and CLN8 (c. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08529-7DOI Listing
March 2019
3.678 Impact Factor

Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood-Brain Barrier is Partially Mediated Through the HIF-1 Pathway.

Neuromolecular Med 2019 Mar 26. Epub 2019 Mar 26.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 South Coulter Street, Amarillo, TX, 79106, USA.

The blood-brain barrier (BBB) plays an important role in brain homeostasis. Hypoxia/ischemia constitutes an important stress factor involved in several neurological disorders by inducing the disruption of the BBB, ultimately leading to cerebral edema formation. Yet, our current understanding of the cellular and molecular mechanisms underlying the BBB disruption following cerebral hypoxia/ischemia remains limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08531-zDOI Listing

Pre-treatment with microRNA-181a Antagomir Prevents Loss of Parvalbumin Expression and Preserves Novel Object Recognition Following Mild Traumatic Brain Injury.

Neuromolecular Med 2019 Mar 21. Epub 2019 Mar 21.

Dept of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305-5117, USA.

Mild traumatic brain injury (mTBI) can result in permanent impairment in memory and learning and may be a precursor to other neurological sequelae. Clinical treatments to ameliorate the effects of mTBI are lacking. Inhibition of microRNA-181a (miR-181a) is protective in several models of cerebral injury, but its role in mTBI has not been investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08532-yDOI Listing
March 2019
2 Reads

C9orf72 Intermediate Alleles in Patients with Amyotrophic Lateral Sclerosis, Systemic Lupus Erythematosus, and Rheumatoid Arthritis.

Neuromolecular Med 2019 Mar 11. Epub 2019 Mar 11.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

The commonest genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a large hexanucleotide expansion within the non-coding region of the C9orf72 gene. The pathogenic mechanisms of the mutation seem toxic gain of functions, while haploinsufficiency alone appears insufficient to cause neurodegeneration. C9orf72 mice rather develop features of autoimmunity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08528-8DOI Listing
March 2019
1 Read
3.678 Impact Factor

Blood Biomarkers for Stroke Diagnosis and Management.

Neuromolecular Med 2019 Mar 4. Epub 2019 Mar 4.

Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, 4-120 Katz Building, 114 Street & 87 Avenue, Edmonton, AB, T6G 2E1, Canada.

Biomarkers are objective indicators used to assess normal or pathological processes, evaluate responses to treatment and predict outcomes. Many blood biomarkers already guide decision-making in clinical practice. In stroke, the number of candidate biomarkers is constantly increasing. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-019-08530-0
Publisher Site
http://dx.doi.org/10.1007/s12017-019-08530-0DOI Listing
March 2019
9 Reads

Network Analysis of Depression-Related Transcriptomic Profiles.

Neuromolecular Med 2019 Mar 1. Epub 2019 Mar 1.

Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, B-616, Boston, MA, 02118, USA.

Major depressive disorder is a common debilitating disorder that is associated with increased morbidity and mortality. However, the molecular mechanism underlying depression remains largely unknown. The current study investigated the association of depression with blood gene expression using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08527-9DOI Listing
March 2019
1 Read

Optogenetic Stimulation of the Anterior Cingulate Cortex Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation, Caudate Putamen as a Site for Alteration.

Neuromolecular Med 2019 Feb 19. Epub 2019 Feb 19.

Institute for Cognitive and Brain Science, Shahid Beheshti University, Tehran, Iran.

Epigenetic agents, such as neonatal isolation during neurodevelopmental period of life, can change various regions of the brain. It may further induce psychological disorders such as autistic-like phenomena. This study indicated the role of chronic increased anterior cingulate cortex (ACC) output on alteration of caudate putamen (CPu) as a main behavior regulator region of the brain in adult maternal deprived (MD) rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08526-wDOI Listing
February 2019
1 Read
3.678 Impact Factor

The Promises and Challenges of Erythropoietin for Treatment of Alzheimer's Disease.

Neuromolecular Med 2019 Mar 17;21(1):12-24. Epub 2019 Jan 17.

Department of Biopharmaceutical Sciences, School of Pharmacy and Health Sciences, Keck Graduate Institute, 535 Watson Dr, Claremont, CA, 91711, USA.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, and intracellular neurofibrillary tangles and extracellular amyloid-beta protein deposits represent the major pathological hallmarks of the disease. Currently available treatments provide some symptomatic relief but fail to modify primary pathological processes that underlie the disease. Erythropoietin (EPO), a hematopoietic growth factor, acts primarily to stimulate erythroid cell production, and is clinically used to treat anemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08524-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407698PMC
March 2019
3 Reads

ADGRL3 rs6551665 as a Common Vulnerability Factor Underlying Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.

Neuromolecular Med 2019 Mar 16;21(1):60-67. Epub 2019 Jan 16.

Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, UFRGS, Avenida Bento Gonçalves, 9500, Porto Alegre, RS, CEP: 91501-970, Brazil.

Neurodevelopmental disorders are prevalent, frequently occur in comorbidity and share substantial genetic correlation. Previous evidence has suggested a role for the ADGRL3 gene in Attention-Deficit/Hyperactivity Disorder (ADHD) susceptibility in several samples. Considering ADGRL3 functionality in central nervous system development and its previous association with neurodevelopmental disorders, we aimed to assess ADGRL3 influence in early-onset ADHD (before 7 years of age) and Autism Spectrum Disorder (ASD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-019-08525-xDOI Listing
March 2019
4 Reads

Tinospora cordifolia Suppresses Neuroinflammation in Parkinsonian Mouse Model.

Neuromolecular Med 2019 Mar 14;21(1):42-53. Epub 2019 Jan 14.

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.

Parkinson's disease (PD), a neurodegenerative central nervous system disorder, is characterised by progressive loss of nigrostriatal neurons in basal ganglia. Previous studies regarding PD have suggested the role of oxidative stress along with neuroinflammation in neurodegeneration. Accordingly, our study explore the anti-inflammatory activity of Tinospora cordifolia aqueous extract (TCAE) in 1-methyl-4-phenyl-1,2,3,6-tetra hydropyridine (MPTP)-intoxicated Parkinsonian mouse model. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-08521-7
Publisher Site
http://dx.doi.org/10.1007/s12017-018-08521-7DOI Listing
March 2019
17 Reads

Therapeutic Approaches to Alzheimer's Disease Through Modulation of NRF2.

Neuromolecular Med 2019 Mar 7;21(1):1-11. Epub 2019 Jan 7.

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/NRF2) is a master transcription factor that regulates oxidative stress-related genes containing the antioxidant response element (ARE) in their promoters. The damaged function and altered localization of NRF2 are found in most neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis. These neurodegenerative diseases developed from various risk factors such as accumulated oxidative stress and genetic and environmental elements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-08523-5DOI Listing
March 2019
10 Reads

A Novel and Mosaic WDR45 Nonsense Variant Causes Beta-Propeller Protein-Associated Neurodegeneration Identified Through Whole Exome Sequencing and X chromosome Heterozygosity Analysis.

Neuromolecular Med 2019 Mar 5;21(1):54-59. Epub 2019 Jan 5.

Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Çapa/istanbul, 34093, Turkey.

Beta-propeller protein-associated neurodegeneration (BPAN) is an X-linked rare dominant disorder of autophagy. The role of WDR45 has been implicated in BPAN almost exclusively in females possibly due to male lethality. Characterization of distinctive clinical manifestations and potentially the complex genetic determinants in rare male patients remain crucial for deciphering BPAN and other X-linked dominant diseases. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-08522-6
Publisher Site
http://dx.doi.org/10.1007/s12017-018-08522-6DOI Listing
March 2019
4 Reads

Hsc70 Interacts with β4GalT5 to Regulate the Growth of Gliomas.

Neuromolecular Med 2019 Mar 3;21(1):33-41. Epub 2019 Jan 3.

Department of Neurosurgery, Yancheng City No. 1 People's Hospital, The Fourth Affiliated Hospital of Nantong University, Yancheng, 224001, People's Republic of China.

Heat shock cognate protein 70 (Hsc70) is a key mediator for the maintenance of intracellular proteins and regulates cellular activities. And it is elevated in various tumor tissues including glioma, which is closely related to the malignancy and poor prognosis of the tumors. However, the effects of Hsc70 on gliomas and its regulatory mechanism have not yet been elucidated. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-08520-8
Publisher Site
http://dx.doi.org/10.1007/s12017-018-08520-8DOI Listing
March 2019
7 Reads

The Emerging Roles of Ferroptosis in Huntington's Disease.

Neuromolecular Med 2019 Jan 2. Epub 2019 Jan 2.

Shaanxi Key Laboratory of Brain Disorders, and Department of Basic Medicine, Xi'an Medical University, Xi'an, 710021, China.

Huntington's disease (HD) is an autosomal dominant and fatal neurodegenerative disorder, which is caused by an abnormal CAG repeat in the huntingtin gene. Despite its well-defined genetic origin, the molecular mechanisms of neuronal death are unclear yet, thus there are no effective strategies to block or postpone the process of HD. Ferroptosis, a recently identified iron-dependent cell death, attracts considerable attention due to its putative involvement in neurodegenerative diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8518-6DOI Listing
January 2019
2 Reads
3.678 Impact Factor

BDNF rs6265 (Val66Met) Polymorphism as a Risk Factor for Blepharospasm.

Neuromolecular Med 2019 Mar 5;21(1):68-74. Epub 2018 Dec 5.

Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.

A few genetic variants are implicated in the development of blepharospasm (BSP). The precise role of the rs6265 on the brain-derived neurotrophic factor (BDNF) gene on BSP remains controversial. The effect of rs6265 on BSP was evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8519-5DOI Listing
March 2019
73 Reads

AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression.

Neuromolecular Med 2019 Mar 8;21(1):25-32. Epub 2018 Nov 8.

National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

Parkinson's disease (PD) is a prevalent neurodegenerative movement disorder that is characterized pathologically by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, the etiology of PD remains poorly understood. Interestingly, recent studies have implicated neuronal energy dysregulation as one of the key perpetrators of the disease. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-8517-7
Publisher Site
http://dx.doi.org/10.1007/s12017-018-8517-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394446PMC
March 2019
16 Reads

CSF Aβ, but not p-Tau, Predicted Progression from Amnestic MCI to Alzheimer's Disease Dementia.

Neuromolecular Med 2018 12 10;20(4):491-497. Epub 2018 Oct 10.

Division of Geriatric Neurology, Neurology Service, Hospital de Clínicas de Porto Alegre (HCPA), Ramiro Barcelos Street, 2350, Porto Alegre, 90035-903, RS, Brazil.

The purpose of the study was to determine whether Aβ and p-Tau cerebral spinal fluid (CSF) levels can predict progression from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease dementia (ADD) in a 3-year follow-up study. All participants were evaluated blindly by a behavioral neurologist and a neuropsychologist, and classified according to the Petersen criteria for aMCI and according to the Clinical Dementia Rating (CDR) scale. Individuals were also submitted to lumbar puncture at baseline. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8516-8DOI Listing
December 2018
3 Reads

The Toll Pathway in the Central Nervous System of Flies and Mammals.

Neuromolecular Med 2018 12 1;20(4):419-436. Epub 2018 Oct 1.

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

Toll receptors, first identified to regulate embryogenesis and immune responses in the adult fly and subsequently defined as the principal sensors of infection in mammals, are increasingly appreciated for their impact on the homeostasis of the central as well as the peripheral nervous systems. Whereas in the context of immunity, the fly Toll and the mammalian TLR pathways have been researched in parallel, the expression pattern and functionality have largely been researched disparately. Herein, we provide data on the expression pattern of the Toll homologues, signaling components, and downstream effectors in ten different cell populations of the adult fly central nervous system (CNS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8515-9DOI Listing
December 2018
2 Reads

Contribution of the Wnt Pathway to Defining Biology of Glioblastoma.

Neuromolecular Med 2018 12 26;20(4):437-451. Epub 2018 Sep 26.

Graduate School of Clinical Neurosciences, University of Pecs, Pecs, Hungary.

Glioblastoma (GBM), a highly lethal brain tumor, has been comprehensively characterized at the molecular level with the identification of several potential treatment targets. Data concerning the Wnt pathway are relatively sparse, but apparently very important in defining several aspects of tumor biology. The Wnt ligands are involved in numerous basic biological processes including regulation of embryogenic development, cell fate determination, and organogenesis, but growing amount of data also support the roles of Wnt pathways in the formation of many tumors, including gliomas. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-8514-x
Publisher Site
http://dx.doi.org/10.1007/s12017-018-8514-xDOI Listing
December 2018
17 Reads

Plasma β-Amyloids and Tau Proteins in Patients with Vascular Cognitive Impairment.

Neuromolecular Med 2018 12 21;20(4):498-503. Epub 2018 Sep 21.

Department of Neurology, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei, 100, Taiwan.

Increases in plasma of β-amyloids (Aβ) and tau proteins have been noted in patients with Alzheimer's dementia (AD). Our study investigated the associations of plasma Aβ and tau proteins with dementia in stroke patients. This cross-sectional study recruited 24 controls (mean age: 67. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8513-yDOI Listing
December 2018
3 Reads

Metabolism of Docosahexaenoic Acid (DHA) Induces Pyroptosis in BV-2 Microglial Cells.

Neuromolecular Med 2018 12 19;20(4):504-514. Epub 2018 Sep 19.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.

DHA is one of the most abundant fatty acids in the brain, largely present in stores of membrane phospholipids. It is readily released by the action of phospholipase A2 and is known to induce anti-inflammatory and neurotrophic effects. It is not thought to contribute to proinflammatory processes in the brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8511-0DOI Listing
December 2018
1 Read

The FOXP3 rs3761547 Gene Polymorphism in Multiple Sclerosis as a Male-Specific Risk Factor.

Neuromolecular Med 2018 12 18;20(4):537-543. Epub 2018 Sep 18.

Department of Neurology, Medical University of Bialystok, Białystok, Poland.

The FOXP3 gene encodes a transcription factor and is predominantly expressed in the CD4CD25 regulatory T cells which plays a pivotal role in the maintenance of immune homeostasis. The defect of FOXP3 gene may provide a critical link between autoimmunity and immune deficiency. The purpose of our study was to evaluate the association of chosen polymorphisms of FOXP3 gene (rs3761549, rs3761548, rs3761547) with different clinical multiple sclerosis (MS) data of our relapsing-remitting groups of patients and in control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8512-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244921PMC
December 2018
3 Reads

Central Orexin A Affects Reproductive Axis by Modulation of Hypothalamic Kisspeptin/Neurokinin B/Dynorphin Secreting Neurons in the Male Wistar Rats.

Neuromolecular Med 2018 Dec 14;20(4):525-536. Epub 2018 Sep 14.

Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

It is an established fact that orexin plays an important role in regulating the reproductive axis and the secretions of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH). However, its precise cellular and molecular mechanisms are not fully recognized. Accordingly, the aim of the present study is to find out whether the central injection of orexin A (OXA) and its antagonists, SB-334867 (as orexin receptor antagonist 1; OX1RA) and JNJ-10397049 (as orexin receptor antagonist 2; OX2RA), either alone or in combination, can leave any impact on the reproductive axis (either hormonal or behavioral) in the male Wistar rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8506-xDOI Listing
December 2018
1 Read

Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and Form Aggregates in the Nucleus.

Neuromolecular Med 2019 Mar 10;21(1):85-96. Epub 2018 Sep 10.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, College of Life Sciences, Beijing Normal University, Beijing, China.

Human tetratricopeptide repeat domain 3 (TTC3) is a gene on 21q22.2 within the Down syndrome critical region (DSCR). Earlier studies suggest that TTC3 may be an important regulator in individual development, especially in neural development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8509-7DOI Listing
March 2019
2 Reads
3.680 Impact Factor

Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma.

Neuromolecular Med 2018 12 4;20(4):452-474. Epub 2018 Sep 4.

Department of Radiation Oncology, Tianjin Hospital, Tianjin, 300211, China.

GBM is the highest incidence in primary intracranial malignancy, and it remains poor prognosis even though the patient is gave standard treatment. Despite decades of intense research, the complex biology of GBM remains elusive. In view of eight hallmarks of cancer which were proposed in 2011, studies related to the eight biological capabilities in GBM have made great progress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8507-9DOI Listing
December 2018
4 Reads

Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic-Ischemic Encephalopathy.

Neuromolecular Med 2019 Mar 3;21(1):75-84. Epub 2018 Sep 3.

Institute of Biomedical Science and Children's Hospital, Fudan University, Shanghai, 201102, China.

Cerebral palsy (CP) is a leading cause of neurological disability among young children. Congenial and adverse perinatal clinical conditions, such as genetic factors, perinatal infection, and asphyxia, are risk factors for CP. Oligodendrocyte transcription factor (OLIG2) is a protein that is expressed in brain oligodendrocyte cells and is involved in neuron repair after brain injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8510-1DOI Listing
March 2019
14 Reads

Overexpression of Human Mutant PANK2 Proteins Affects Development and Motor Behavior of Zebrafish Embryos.

Neuromolecular Med 2018 Aug 23. Epub 2018 Aug 23.

Department of Molecular and Translational Medicine, University of Brescia, viale Europa 11, 25123, Brescia, Italy.

Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a genetic and early-onset neurodegenerative disorder characterized by iron accumulation in the basal ganglia. It is due to mutations in Pantothenate Kinase 2 (PANK2), an enzyme that catalyzes the phosphorylation of vitamin B5, first and essential step in coenzyme A (CoA) biosynthesis. Most likely, an unbalance of the neuronal levels of this important cofactor represents the initial trigger of the neurodegenerative process, yet a complete understanding of the connection between PANK2 malfunctioning and neuronal death is lacking. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-8508-8
Publisher Site
http://dx.doi.org/10.1007/s12017-018-8508-8DOI Listing
August 2018
12 Reads

Neuroprotective Effect of Hydrogen Sulfide in Hyperhomocysteinemia Is Mediated Through Antioxidant Action Involving Nrf2.

Neuromolecular Med 2018 12 13;20(4):475-490. Epub 2018 Aug 13.

Department of Biochemistry, Basic Medical Science Block-II, Sector-25, Panjab University, Chandigarh, 160014, India.

Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism. Elevated plasma Hcy levels (> 15 µM) result in a condition called hyperhomocysteinemia (HHcy), which is an independent risk factor in the development of various neurodegenerative disorders. Reactive oxygen species (ROS) produced by auto-oxidation of Hcy have been implicated in HHcy-associated neurological conditions. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-8505-y
Publisher Site
http://dx.doi.org/10.1007/s12017-018-8505-yDOI Listing
December 2018
21 Reads

DRD3 Gene and ADHD: A Pharmaco-Behavioural Genetic Study.

Neuromolecular Med 2018 12 26;20(4):515-524. Epub 2018 Jul 26.

Douglas Mental Health University Institute, Montreal, QC, Canada.

Results of candidate gene investigations in ADHD have been difficult to replicate. The complexity of the phenotypes and their underlying determinants, and the relatively small effect sizes of genetic variants may, in part, be contributing to these inconsistencies. The objective of this study is to conduct an exploratory analysis using a comprehensive approach to investigate the role of candidate genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8504-zDOI Listing
December 2018
1 Read

Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons.

Neuromolecular Med 2018 09 18;20(3):281-300. Epub 2018 Jul 18.

Technical University of Sofia, Klement Ohridksi 8, 1000, Sofia, Bulgaria.

The astrocyte-neuron lactate shunt (ANLS) hypothesis is the most widely accepted model of brain glucose metabolism. However, over the past decades, research has shown that neuronal and astrocyte plasma membrane receptors, in particular, GLUT2, Kir6.2 subunit of the potassium ATP-channel, SGLT-3 acting as glucosensors, play a pivotal role in brain glucose metabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8503-0DOI Listing
September 2018
2 Reads

RNA Sequencing and Pathway Analysis Identify Important Pathways Involved in Hypertrichosis and Intellectual Disability in Patients with Wiedemann-Steiner Syndrome.

Neuromolecular Med 2018 09 16;20(3):409-417. Epub 2018 Jul 16.

Inserm, U1016, Institut Cochin, Paris, France.

A growing number of histone modifiers are involved in human neurodevelopmental disorders, suggesting that proper regulation of chromatin state is essential for the development of the central nervous system. Among them, heterozygous de novo variants in KMT2A, a gene coding for histone methyltransferase, have been associated with Wiedemann-Steiner syndrome (WSS), a rare developmental disorder mainly characterized by intellectual disability (ID) and hypertrichosis. As KMT2A is known to regulate the expression of multiple target genes through methylation of lysine 4 of histone 3 (H3K4me), we sought to investigate the transcriptomic consequences of KMT2A variants involved in WSS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8502-1DOI Listing
September 2018
18 Reads

Potential Role of Brain-Derived Neurotrophic Factor and Dopamine Receptor D2 Gene Variants as Modifiers for the Susceptibility and Clinical Course of Wilson's Disease.

Neuromolecular Med 2018 Sep 10;20(3):401-408. Epub 2018 Jul 10.

S. N. Pradhan Centre for Neurosciences, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.

Wilson's disease (WD), an inborn error of copper metabolism caused by mutations in the ATPase copper transporting beta (ATP7B) gene, manifests variable age of onset and different degrees of hepatic and neurological disturbances. This complex phenotypical outcome of a classical monogenic disease can possibly be explained by modifier loci regulating the clinical course of the disease. The brain-derived neurotropic factor (BDNF), critical for the survival, morphogenesis, and plasticity of the neurons, and the dopamine receptor D2 (DRD2), one of the most abundant dopamine receptors in the brain, have been highlighted in the pathophysiology of various neuropsychiatric diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8501-2DOI Listing
September 2018
7 Reads

Cerebrospinal Fluid C-Reactive Protein in Parkinson's Disease: Associations with Motor and Non-motor Symptoms.

Neuromolecular Med 2018 09 6;20(3):376-385. Epub 2018 Jul 6.

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Parkinson' disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non-motor symptoms of PD. One of the most notable inflammatory proteins is C-reactive protein (CRP), which is elevated in the conditions of systemic inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8499-5DOI Listing
September 2018
7 Reads

Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway.

Neuromolecular Med 2018 09 3;20(3):386-400. Epub 2018 Jul 3.

Department of Physiology, School of Medicine, Selçuk University, Konya, 42131, Turkey.

This study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1α, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8500-3DOI Listing
September 2018
14 Reads

The Transcriptional Regulatory Properties of Amyloid Beta 1-42 may Include Regulation of Genes Related to Neurodegeneration.

Neuromolecular Med 2018 09 12;20(3):363-375. Epub 2018 Jun 12.

Brain and Neurodegenerative Disorders Research Laboratory, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, 34098, Istanbul, Turkey.

Our previous study demonstrated the translocation of Aβ1-42 to the nucleus in response to antibiotic treatment, and interpreted it as a possible transcriptional response of Aβ1-42 to antibiotics. The present study aims to investigate how amyloid acts on the key elements of neurodegeneration and the molecules involved in the induction of Aβ1-42 production. For this purpose, we investigated the acute effect of Aβ1-42 on the transcriptional levels of genes that have roles in the mechanisms that produce Aβ itself: alpha secretase (ADAM10), beta secretase (BACE1), the gamma secretase complex (PS-1, PS-2, Nicastrin), the substrate APP, APOE (the significant risk factor for sporadic form of the AD), TREM2 (recently indicated as a contributor to AD risk), NMDAR subunits and PKCzeta (contributors of memory and learning), and key elements of tau pathology such as tau, GSK3α, GSK3β, and Cdk5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8498-6DOI Listing
September 2018
6 Reads

Effects of Low Phytanic Acid-Concentrated DHA on Activated Microglial Cells: Comparison with a Standard Phytanic Acid-Concentrated DHA.

Neuromolecular Med 2018 09 30;20(3):328-342. Epub 2018 May 30.

Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain.

Docosahexaenoic acid (DHA, 22:6 n-3) is an essential omega-3 (ω-3) long chain polyunsaturated fatty acid of neuronal membranes involved in normal growth, development, and function. DHA has been proposed to reduce deleterious effects in neurodegenerative processes. Even though, some inconsistencies in findings from clinical and pre-clinical studies with DHA could be attributed to the presence of phytanic acid (PhA) in standard DHA treatments. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-8496-8
Publisher Site
http://dx.doi.org/10.1007/s12017-018-8496-8DOI Listing
September 2018
12 Reads

Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation.

Neuromolecular Med 2018 09 30;20(3):343-362. Epub 2018 May 30.

Medical Biotechnology Laboratory, Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

Reactive gliosis, microgliosis, and subsequent secretion of various inflammatory mediators like cytokines, proteases, reactive oxygen, and nitrogen species are the suggested key players associated with systemic inflammation-driven neuroinflammation and cognitive impairments in various neurological disorders. Conventionally, non-steroidal anti-inflammatory drugs are prescribed to suppress inflammation but due to their adverse effects, their usage is not well accepted. Natural products are emerging better therapeutic agents due to their affordability and inherent pleiotropic biological activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8497-7DOI Listing
September 2018
23 Reads

Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway.

Neuromolecular Med 2018 09 25;20(3):312-327. Epub 2018 May 25.

College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk, 28160, Republic of Korea.

Amyloidogenesis is known to cause Alzheimer's disease. Our previous studies have found that lipopolysaccharide (LPS) causes neuroinflammation and amyloidogenesis through activation of nuclear factor kappaB (NF-κB). Piperlongumine (PL) is an alkaloid amide found naturally in long pepper (Piper longum) isolates; it was reported to have inhibitory effects on NF-κB activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8495-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097046PMC
September 2018
9 Reads
3.680 Impact Factor

CD271+, CXCR7+, CXCR4+, and CD133+ Stem/Progenitor Cells and Clinical Characteristics of Acute Ischemic Stroke Patients.

Neuromolecular Med 2018 Sep 9;20(3):301-311. Epub 2018 May 9.

Department of Adult Neurology, Medical University of Gdańsk, University Clinical Center, Dębinki 7, 80-211, Gdańsk, Poland.

Ischemic stroke causes mobilization of various groups of progenitor cells from bone marrow to bloodstream and this correlates with the neurological status of stroke patients. The goal of our study was to identify the activity of chosen progenitor/stem cells in the peripheral blood of acute ischemic stroke patients in the first 7 days after the incident, through associations between the levels of the cells and clinical features of the patients. Thirty-three acute ischemic stroke patients and 15 non-stroke control subjects had their venous blood collected repeatedly in order to assess the levels of the CD45-CD34 + CD271+, the CD45-CD34 + CXCR4+, the CD45-CD34 + CXCR7+, and the CD45-CD34 + CD133+ stem/progenitor cells by means of flow cytometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8494-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097064PMC
September 2018
4 Reads

The Dynamics of Neurosteroids and Sex-Related Hormones in the Pathogenesis of Alzheimer's Disease.

Neuromolecular Med 2018 Jun 4;20(2):215-224. Epub 2018 May 4.

Stem Cell Research Center, Tabriz University of Medical Sciences, Imam Reza St., Golgasht St., Tabriz, Iran.

Alzheimer's disease (AD) is commonly diagnosed by vast extracellular amyloid deposits and existence of intracellular neurofibrillary tangles. In accordance with the literature, age-related loss of sex steroid hormones in either males or females was found in relation to AD subjects. The dynamics of these hormones have been previously described in both physiological and pathological conditions with the evidence of changes in various intracellular signalings regarding the neurodegenerative disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8493-yDOI Listing
June 2018
4 Reads
3.680 Impact Factor

Association of CALM1 rs3179089 Polymorphism with Ischemic Stroke in Chinese Han Population.

Neuromolecular Med 2018 06 30;20(2):271-279. Epub 2018 Apr 30.

School of Public Health of Guangxi Medical University, Nanning, Guangxi, China.

A quantitative transcriptomics analysis has reported that Calmodulin 1 (CALM1) is highly expressed in human brain tissues. This study aims to evaluate the relationship between CALM1 rs3179089 polymorphism and ischemic stroke (IS) in Chinese Han population. A total of 550 patients with IS and 550 control subjects were recruited and genotyped using Sequenom MassArray technology. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-8492-z
Publisher Site
http://dx.doi.org/10.1007/s12017-018-8492-zDOI Listing
June 2018
8 Reads

BDNF/TrkB Pathway Mediates the Antidepressant-Like Role of HS in CUMS-Exposed Rats by Inhibition of Hippocampal ER Stress.

Neuromolecular Med 2018 06 27;20(2):252-261. Epub 2018 Apr 27.

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, University of South China, 28 West Changsheng Road, Hengyang, 421001, Hunan, People's Republic of China.

Our previous works have shown that hydrogen sulfide (HS) significantly attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors and hippocampal endoplasmic reticulum (ER) stress. Brain-derived neurotrophic factor (BDNF) generates an antidepressant-like effect by its receptor tyrosine protein kinase B (TrkB). We have previously found that HS upregulates the expressions of BDNF and p-TrkB in the hippocampus of CUMS-exposed rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8489-7DOI Listing
June 2018
13 Reads

Improved Bioavailability of Levodopa Using Floatable Spray-Coated Microcapsules for the Management of Parkinson's Disease.

Neuromolecular Med 2018 06 25;20(2):262-270. Epub 2018 Apr 25.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Oral administration of levodopa (LD) is the gold standard in managing Parkinson's disease (PD). Although LD is the most effective drug in treating PD, chronic administration of LD induces levodopa-induced dyskinesia. A continuous and sustained provision of LD to the brain could, therefore, reduce peak-dose dyskinesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8491-0DOI Listing
June 2018
12 Reads

How to Spot Congenital Myasthenic Syndromes Resembling the Lambert-Eaton Myasthenic Syndrome? A Brief Review of Clinical, Electrophysiological, and Genetics Features.

Neuromolecular Med 2018 06 25;20(2):205-214. Epub 2018 Apr 25.

Department of Neuropediatrics and Muscle Disorders, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Congenital myasthenic syndromes (CMS) are heterogeneous genetic diseases in which neuromuscular transmission is compromised. CMS resembling the Lambert-Eaton myasthenic syndrome (CMS-LEMS) are emerging as a rare group of distinct presynaptic CMS that share the same electrophysiological features. They have low compound muscular action potential amplitude that increment after brief exercise (facilitation) or high-frequency repetitive nerve stimulation. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12017-018-8490-1
Publisher Site
http://dx.doi.org/10.1007/s12017-018-8490-1DOI Listing
June 2018
23 Reads

Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation.

Neuromolecular Med 2018 06 24;20(2):161-173. Epub 2018 Apr 24.

Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA.

Autism spectrum disorders (ASD) are the most prevalent set of pediatric neurobiological disorders. The etiology of ASD has both genetic and environmental components including possible dysfunction of the immune system. The relationship of the immune system to aberrant neural circuitry output in the form of altered behaviors and communication characterized by ASD is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8488-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942347PMC
June 2018
11 Reads

Secretome of Differentiated PC12 Cells Restores the Monocrotophos-Induced Damages in Human Mesenchymal Stem Cells and SHSY-5Y Cells: Role of Autophagy and Mitochondrial Dynamics.

Neuromolecular Med 2018 06 30;20(2):233-251. Epub 2018 Mar 30.

System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India.

A perturbed cellular homeostasis is a key factor associated with xenobiotic exposure resulting in various ailments. The local cellular microenvironment enriched with secretory components aids in cell-cell communication that restores this homeostasis. Deciphering the underlying mechanism behind this restorative potential of secretome could serve as a possible solution to many health hazards. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12017-018-8487-9DOI Listing
June 2018
9 Reads