16,604 results match your criteria NeuroImage[Journal]


Age differences in specific neural connections within the Default Mode Network underlie theory of mind.

Neuroimage 2019 Feb 19. Epub 2019 Feb 19.

Indiana University, Bloomington, USA.

Theory of mind (i.e., the ability to infer others' mental states) - a fundamental social cognitive ability - declines with increasing age. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.024DOI Listing
February 2019

Contributions of non-primary cortical sources to auditory temporal processing.

Neuroimage 2019 Feb 19. Epub 2019 Feb 19.

Research Group Experimental ORL, Department of Neurosciences, KU Leuven - University of Leuven, Belgium.

Temporal processing is essential for speech perception and directional hearing. However, the number and locations of cortical sources involved in auditory temporal processing are still a matter of debate. Using source reconstruction of human EEG responses, we show that, in addition to primary sources in the auditory cortices, sources outside the auditory cortex, designated as non-primary sources, are involved in auditory temporal processing. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.037DOI Listing
February 2019

The association of health-related quality of life and cerebral gray matter volume in the context of aging: A voxel-based morphometry study with a general population sample.

Neuroimage 2019 Feb 18. Epub 2019 Feb 18.

Department Health and Prevention, Institute of Psychology, University of Greifswald, Germany.

Health-related quality of life is likely associated with the brain via processes relating to physiology, behavior, cognition, emotion and stress. Previous studies with small student or clinical samples have identified associations with gray matter volume in the anterior cingulate cortex, prefrontal cortex, insular cortex, (para)hippocampal area, amygdala, and precuneus. The present study investigated the association of gray matter volume of these brain areas with mental and physical components of health, as well as general health perception, measured with the 12-item Short Form Health Survey, in a large sample of 3027 participants from the Study of Health in Pomerania, using voxel-based morphometry for T1-weighted magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.035DOI Listing
February 2019

Amygdala-prefrontal cortex white matter tracts are widespread, variable and implicated in amygdala modulation in adolescents.

Neuroimage 2019 Feb 18. Epub 2019 Feb 18.

Department of Psychology, University of Michigan, Ann Arbor, MI, USA; Population Studies Center of the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address:

The amygdala is critically involved in processing emotion. Through bidirectional connections, the prefrontal cortex (PFC) is hypothesized to influence amygdala reactivity. However, research that elucidates the nature of amygdala-PFC interactions - through mapping amygdala-prefrontal tracts, quantifying variability among tracts, and linking this variability to amygdala activation - is lacking. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.009DOI Listing
February 2019

Age-related alterations in axonal microstructure in the corpus callosum measured by high-gradient diffusion MRI.

Neuroimage 2019 Feb 18. Epub 2019 Feb 18.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Harvard Medical School, Boston, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Cerebral white matter exhibits age-related degenerative changes during the course of normal aging, including decreases in axon density and alterations in axonal structure. Noninvasive approaches to measure these microstructural alterations throughout the lifespan would be invaluable for understanding the substrate and regional variability of age-related white matter degeneration. Recent advances in diffusion magnetic resonance imaging (MRI) have leveraged high gradient strengths to increase sensitivity toward axonal size and density in the living human brain. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.036DOI Listing
February 2019

Cerebellar resting-state functional connectivity in Parkinson's disease and multiple system atrophy: Characterization of abnormalities and potential for differential diagnosis at the single-patient level.

Neuroimage Clin 2019 Feb 13;22:101720. Epub 2019 Feb 13.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain; Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institute of Neuroscience, University of Barcelona, Barcelona, Catalonia, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain. Electronic address:

Background: Recent studies using resting-state functional connectivity and machine-learning to distinguish patients with neurodegenerative diseases from other groups of subjects show promising results. This approach has not been tested to discriminate between Parkinson's disease (PD) and multiple system atrophy (MSA) patients.

Objectives: Our first aim is to characterize possible abnormalities in resting-state functional connectivity between the cerebellum and a set of intrinsic-connectivity brain networks and between the cerebellum and different regions of the striatum in PD and MSA. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101720DOI Listing
February 2019

Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping.

Neuroimage Clin 2019 Feb 13;22:101721. Epub 2019 Feb 13.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.

One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101721DOI Listing
February 2019

Segregation of salience network predicts treatment response of depression to repetitive transcranial magnetic stimulation.

Neuroimage Clin 2019 Feb 13;22:101719. Epub 2019 Feb 13.

Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Background: The present study tested the hypothesis that network segregation, a graph theoretic measure of functional organization of the brain, is correlated with treatment response in patients with major depressive disorder (MDD) undergoing repetitive transcranial magnetic stimulation (rTMS).

Methods: Network segregation, calculated from resting state functional magnetic resonance imaging scans, was measured in 32 patients with MDD who entered a sham-controlled, double-blinded, randomized trial of rTMS to the left dorsolateral prefrontal cortex, and a cohort of 20 healthy controls (HCs). Half of the MDD patients received sham treatment in the blinded phase, followed by active rTMS in the open-label phase. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101719DOI Listing
February 2019

Reliability of supraspinal correlates to lower urinary tract stimulation in healthy participants - A fMRI study.

Neuroimage 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland. Electronic address:

Previous functional neuroimaging studies provided evidence for a specific supraspinal network involved in lower urinary tract (LUT) control. However, data on the reliability of blood oxygenation level-dependent (BOLD) signal changes during LUT task-related functional magnetic resonance imaging (fMRI) across separate measurements are lacking. Proof of the latter is crucial to evaluate whether fMRI can be used to assess supraspinal responses to LUT treatments. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.031DOI Listing
February 2019

Distinct visuo-motor brain dynamics for real-world objects versus planar images.

Neuroimage 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychology, University of Nevada, 1664 N Virginia St, Reno, NV, 89557-0296, USA. Electronic address:

Ultimately, we aim to generalize and translate scientific knowledge to the real world, yet current understanding of human visual perception is based predominantly on studies of two-dimensional (2-D) images. Recent cognitive-behavioral evidence shows that real objects are processed differently to images, although the neural processes that underlie these differences are unknown. Because real objects (unlike images) afford actions, they may trigger stronger or more prolonged activation in neural populations for visuo-motor action planning. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.026DOI Listing
February 2019

I feel what I do: Relating interoceptive processes and reward-related behavior.

Neuroimage 2019 Feb 16. Epub 2019 Feb 16.

Department of Psychology, General and Experimental Psychology Unit, Ludwig-Maximilians University, D-80802, Munich, Germany.

Interoceptive signalling has been shown to contribute to action regulation and action experience. Here, we assess whether motor behaviour can be influenced by anticipated homeostatic feeling states induced through different predictable contexts. Participants performed a reward incentive paradigm in which accurate responses increased (gain) or avoided the depletion (averted loss) of a credit score. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.032DOI Listing
February 2019

Structural brain network measures are superior to vascular burden scores in predicting early cognitive impairment in post stroke patients with small vessel disease.

Neuroimage Clin 2019 Feb 5;22:101712. Epub 2019 Feb 5.

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.

Objectives: In this cross-sectional study, we aimed to explore the mechanisms of early cognitive impairment in a post stroke non-dementia cerebral small vessel disease (SVD) cohort by comparing the SVD score with the structural brain network measures.

Method: 127 SVD patients were recruited consecutively from a stroke clinic, comprising 76 individuals with mild cognitive impairment (MCI) and 51 with no cognitive impairment (NCI). Detailed neuropsychological assessments and multimodal MRI were performed. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101712DOI Listing
February 2019

Desynchronizing to be faster? Perceptual- and attentional-modulation of brain rhythms at the sub-millisecond scale.

Neuroimage 2019 Feb 14. Epub 2019 Feb 14.

Department of Integrative Physiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, 444-8585, Japan.

Neural oscillatory signals has been associated with many high-level functions (e.g. attention and working memory), because they reflect correlated behaviors of neural population that would facilitate the information transfer in the brain. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.027DOI Listing
February 2019

Hierarchical complexity of the adult human structural connectome.

Neuroimage 2019 Feb 14;191:205-215. Epub 2019 Feb 14.

Usher Institute for Population Health Science and Informatics, Medical School, University of Edinburgh, Edinburgh, EH16 4UX, UK.

The structural network of the human brain has a rich topology which many have sought to characterise using standard network science measures and concepts. However, this characterisation remains incomplete and the non-obvious features of this topology have largely confounded attempts towards comprehensive constructive modelling. This calls for new perspectives. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.028DOI Listing
February 2019

High-resolution metabolic mapping of gliomas via patch-based super-resolution magnetic resonance spectroscopic imaging at 7T.

Neuroimage 2019 Feb 14. Epub 2019 Feb 14.

High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Clinical Molecular MR Imaging, Austria. Electronic address:

Objectives: To demonstrate the feasibility of 7 T magnetic resonance spectroscopic imaging (MRSI), combined with patch-based super-resolution (PBSR) reconstruction, for high-resolution multi-metabolite mapping of gliomas.

Materials And Methods: Ten patients with WHO grade II, III and IV gliomas (6/4, male/female; 45 ± 9 years old) were prospectively measured between 2014 and 2018 on a 7 T whole-body MR imager after routine 3 T magnetic resonance imaging (MRI) and positron emission tomography (PET). Free induction decay MRSI with a 64 × 64-matrix and a nominal voxel size of 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193010
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http://dx.doi.org/10.1016/j.neuroimage.2019.02.023DOI Listing
February 2019
2 Reads

The representation of symmetry in multi-voxel response patterns and functional connectivity throughout the ventral visual stream.

Neuroimage 2019 Feb 13. Epub 2019 Feb 13.

Brain and Cognition, KU Leuven, Leuven, Belgium; Leuven Brain Institute, KU Leuven, Leuven, Belgium. Electronic address:

Several computational models explain how symmetry might be detected and represented in the human brain. However, while there is an abundance of psychophysical studies on symmetry detection and several neural studies showing where and when symmetry is detected in the brain, important questions remain about how this detection happens and how symmetric patterns are represented. We studied the representation of (vertical) symmetry in regions of the ventral visual stream, using multi-voxel pattern analyses (MVPA) and functional connectivity analyses. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.030DOI Listing
February 2019

Directional tuning for eye and arm movements in overlapping regions in human posterior parietal cortex.

Neuroimage 2019 Feb 12. Epub 2019 Feb 12.

Center for Mind/Brain Sciences (CIMeC), University of Trento, Italy; Department of Cognitive Science, University of Trento, Italy; Department of Psychology, Royal Holloway University of London, UK. Electronic address:

A network of frontal and parietal regions is known to be recruited during the planning and execution of arm and eye movements. While movements of the two effectors are typically coupled with each other, it remains unresolved how information is shared between them. Here we aimed to identify regions containing neuronal populations that show directional tuning for both arm and eye movements. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.029DOI Listing
February 2019

Volume alterations of brainstem subregions in migraine with aura.

Neuroimage Clin 2019 Feb 4;22:101714. Epub 2019 Feb 4.

Faculty of Medicine, University of Belgrade, Serbia; Center for Headaches, Neurology Clinic, Clinical Center of Serbia, Serbia.

Background: The brainstem plays a significant role in migraine pathogenesis, but a relationship between volume alterations of brainstem subregions and migraine aura characteristics has not been sufficiently investigated. The aim of this study is to compare the volume of the brainstem, and its subregions, between patients with a migraine with aura (MwA) and healthy controls (HC), and also to correlate characteristics of MwA and the volume of the brainstem subregions.

Methods: Forty-two MwA and 42 HCs, balanced by sex and age, were selected for this study. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101714DOI Listing
February 2019

The organization of the basal ganglia functional connectivity network is non-linear in Parkinson's disease.

Neuroimage Clin 2019 Feb 3;22:101708. Epub 2019 Feb 3.

Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Spain. Electronic address:

The motor symptoms in Parkinson's disease (PD) have been linked to changes in the excitatory/inhibitory interactions of centers involved in the cortical-subcortical closed-loop circuits which connect basal ganglia (BG) and the brain cortex. This approach may explain some motor symptoms of PD but not others, which has driven the study of BG from new perspectives. Besides their cortical-subcortical linear circuits, BG have a number of subcortical circuits which directly or indirectly connect each BG with all the others. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101708DOI Listing
February 2019
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Prolonged functional development of the parahippocampal place area and occipital place area.

Neuroimage 2019 Feb 11;191:104-115. Epub 2019 Feb 11.

TU Dortmund University, Faculty of Rehabilitation Sciences, Department of Vision, Visual Impairments & Blindness, Emil-Figge-Str. 50, 44227, Dortmund, Germany. Electronic address:

Successful navigation of our surroundings is of high environmental relevance and involves processing of the visual scenery. Scene-processing undergoes a major behavioral improvement during childhood. However, possible neural changes that underlie this cognitive development in scene perception are understudied in comparison to other stimulus categories. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.025DOI Listing
February 2019

White matter microstructure correlates of general and specific second-order factors of psychopathology.

Neuroimage Clin 2019 Feb 1;22:101705. Epub 2019 Feb 1.

Department of Psychological Sciences, Vanderbilt University, Nashville, TN, United States.

Increasing data indicate that prevalent forms of psychopathology can be organized into second-order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Nevertheless, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories, ignoring the highly correlated nature of psychopathology. Thus, for instance, although perturbations in white matter microstructure have been identified across a range of mental disorders, nearly all such studies used case-control designs, leaving it unclear whether observed relations reflect disorder-specific characteristics or transdiagnostic associations. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369105PMC
February 2019

Quasi-periodic patterns contribute to functional connectivity in the brain.

Neuroimage 2019 Feb 10;191:193-204. Epub 2019 Feb 10.

Neuroscience, Emory University, 1760 Haygood Dr NE Suite W-200, Atlanta, GA, 30322, USA; Biomedical Engineering, Emory University and Georgia Institute of Technology, 1760, Haygood Dr NE Suite, W-200, Atlanta, GA, 30322, USA. Electronic address:

Functional connectivity is widely used to study the coordination of activity between brain regions over time. Functional connectivity in the default mode and task positive networks is particularly important for normal brain function. However, the processes that give rise to functional connectivity in the brain are not fully understood. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.01.076DOI Listing
February 2019

Improved state change estimation in dynamic functional connectivity using hidden semi-Markov models.

Neuroimage 2019 Feb 9. Epub 2019 Feb 9.

Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

The study of functional brain networks has grown rapidly over the past decade. While most functional connectivity (FC) analyses estimate one static network structure for the entire length of the functional magnetic resonance imaging (fMRI) time series, recently there has been increased interest in studying time-varying changes in FC. Hidden Markov models (HMMs) have proven to be a useful modeling approach for discovering repeating graphs of interacting brain regions (brain states). Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.013DOI Listing
February 2019

Mapping tissue pH in an experimental model of acute stroke - Determination of graded regional tissue pH changes with non-invasive quantitative amide proton transfer MRI.

Neuroimage 2019 Feb 10. Epub 2019 Feb 10.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. Electronic address:

pH-weighted amide proton transfer (APT) MRI is sensitive to tissue pH change during acute ischemia, complementing conventional perfusion and diffusion stroke imaging. However, the currently used pH-weighted magnetization transfer (MT) ratio asymmetry (MTR) analysis is of limited pH specificity. To overcome this, MT and relaxation normalized APT (MRAPT) analysis has been developed that to homogenize the background signal, thus providing highly pH conspicuous measurement. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.022DOI Listing
February 2019
1 Read
6.357 Impact Factor

Left perirhinal cortex codes for semantic similarity between written words defined from cued word association.

Neuroimage 2019 Feb 10;191:127-139. Epub 2019 Feb 10.

Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium; Neurology Department, University Hospitals Leuven, 3000, Leuven, Belgium. Electronic address:

Knowledge of visual and nonvisual attributes of concrete entities is distributed over neocortical uni- and polymodal association cortex. Here we investigated the role of left perirhinal cortex in explicit knowledge retrieval from written words. We examined whether it extended across visual and nonvisual properties, animate and inanimate entities, how this differed from picture input and how specific it was for perirhinal cortex compared to surrounding structures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193009
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http://dx.doi.org/10.1016/j.neuroimage.2019.02.011DOI Listing
February 2019
4 Reads
6.357 Impact Factor

An increase in sleep slow waves predicts better working memory performance in healthy individuals.

Neuroimage 2019 Feb 10;191:1-9. Epub 2019 Feb 10.

University of Pittsburgh School of Medicine, Department of Psychiatry, USA. Electronic address:

Sleep is imperative for brain health and well-being, and restorative sleep is associated with better cognitive functioning. Increasing evidence indicates that electrophysiological measures of sleep, especially slow wave activity (SWA), regulate the consolidation of motor and perceptual procedural memory. In contrast, the role of sleep EEG and SWA in modulating executive functions, including working memory (WM), has been far less characterized. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.020DOI Listing
February 2019
5 Reads

White-matter pathways and semantic processing: intrasurgical and lesion-symptom mapping evidence.

Neuroimage Clin 2019 Jan 31;22:101704. Epub 2019 Jan 31.

Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute- IDIBELL, 08097, L'Hospitalet de Llobregat, Barcelona, Spain; Dept. of Cognition, Development and Education Psychology, University of Barcelona, Campus Bellvitge, 08097, L'Hospitalet de Llobregat, Barcelona, Spain; Catalan Institution for Research and Advanced Studies, ICREA, 08010 Barcelona, Spain. Electronic address:

In the present study, we aimed to test the association between the correct function of the left ventral white matter pathways and semantic processing (dual stream models for language processing, Hickok & Poeppel, 2004), using a new set of language tasks during intraoperative electrical stimulation at white matter level. Additionally, we evaluated brain regions needed for correct performance on the different semantic tasks using lesion-symptom analyses (voxel lesion-symptom mapping and track-wise lesion analysis) in a sample of 62 candidates for the awake brain surgery. We found that electrical stimulation in the vicinity of the inferior longitudinal and inferior fronto-occipital fasciculi disturbed performance on semantic processing tasks. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370559PMC
January 2019

Hypercapnic BOLD MRI compared to HO PET/CT for the hemodynamic evaluation of patients with Moyamoya Disease.

Neuroimage Clin 2019 Feb 4;22:101713. Epub 2019 Feb 4.

Department of Neurosurgery, Eberhard Karls University Tübingen, Germany.

Background And Purpose: Patients with Moyamoya Disease (MMD) need hemodynamic evaluation of vascular territories at risk of stroke. Today's investigative standards include HO PET/CT with pharmacological challenges with acetazolamide (ACZ). Recent developments suggest that CO-triggered blood‑oxygen-level-dependent (BOLD) functional MRI might provide comparable results to current standard methods for evaluation of territorial hemodynamics, while being a more widely available and easily implementable method. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370561PMC
February 2019

Detecting frontotemporal dementia syndromes using MRI biomarkers.

Neuroimage Clin 2019 Feb 4;22:101711. Epub 2019 Feb 4.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.

Background: Diagnosing frontotemporal dementia may be challenging. New methods for analysis of regional brain atrophy patterns on magnetic resonance imaging (MRI) could add to the diagnostic assessment. Therefore, we aimed to develop automated imaging biomarkers for differentiating frontotemporal dementia subtypes from other diagnostic groups, and from one another. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369219PMC
February 2019
1 Read

Involvement of hippocampal subfields and anterior-posterior subregions in encoding and retrieval of item, spatial, and associative memories: Longitudinal versus transverse axis.

Neuroimage 2019 Feb 8. Epub 2019 Feb 8.

Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada; Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

The functional role of the hippocampal formation in episodic memory has been studied using functional magnetic resonance imaging (fMRI) for many years. The hippocampus can be segmented into three major anteroposterior sections, called head, body and tail, and into the Cornu Ammonis (CA), dentate gyrus (DG), and subiculum (Sub) subfields based on its transverse axis. However, the exact role of these subregions and subfields in memory processes is less understood. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.01.061DOI Listing
February 2019

Investigating the variability of cardiac pulse artifacts across heartbeats in simultaneous EEG-fMRI recordings: A 7T study.

Neuroimage 2019 Feb 8;191:21-35. Epub 2019 Feb 8.

Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Department of Radiology, University of Lausanne, Lausanne, Switzerland; Department of Radiology, University of Geneva, Geneva, Switzerland.

Electroencephalography (EEG) recordings performed in magnetic resonance imaging (MRI) scanners are affected by complex artifacts caused by heart function, often termed pulse artifacts (PAs). PAs can strongly compromise EEG data quality, and remain an open problem for EEG-fMRI. This study investigated the properties and mechanisms of PA variability across heartbeats, which has remained largely unaddressed to date, and evaluated its impact on PA correction approaches. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.021DOI Listing
February 2019

Identifying brain changes related to cognitive aging using VBM and visual rating scales.

Neuroimage Clin 2019 Feb 5;22:101697. Epub 2019 Feb 5.

KU Leuven -University of Leuven, Department of Neurosciences, Laboratory for Neuro-& Psychophysiology, Leuven, Belgium.

Aging is often associated with changes in brain structures as well as in cognitive functions. Structural changes can be visualized with Magnetic Resonance Imaging (MRI) using voxel-based grey matter morphometry (VBM) and visual rating scales to assess atrophy level. Several MRI studies have shown that possible neural correlates of cognitive changes can be seen in normal aging. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370556PMC
February 2019

Increased heartbeat-evoked potential during REM sleep in nightmare disorder.

Neuroimage Clin 2019 Jan 29;22:101701. Epub 2019 Jan 29.

Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland.

Nightmares are characterized by the experience of strong negative emotions occurring mainly during REM sleep. Some people suffer from nightmare disorder, which is defined by the repeated occurrence of nightmares and by significant distress in wakefulness. Yet, whether frequent nightmares relate to a general increase in emotional reactivity or arousal during sleep remains unclear. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370851PMC
January 2019

Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI.

Neuroimage Clin 2019 Jan 30;22:101699. Epub 2019 Jan 30.

Athinoula A. Martinos Center for Biomedical Imaging and Harvard Medical School, Boston, MA, USA.; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. Electronic address:

Irreversible white matter (WM) damage, including severe demyelination and axonal loss, is a main determinant of long-term disability in multiple sclerosis (MS). Non-invasive detection of changes in microstructural WM integrity in the disease is challenging since commonly used imaging metrics lack the necessary sensitivity, especially in the early phase of the disease. This study aims at assessing microstructural WM abnormalities in early-stage MS by using ultra-high gradient strength multi-shell diffusion MRI and the restricted signal fraction (FR) from the Composite Hindered and Restricted Model of Diffusion (CHARMED), a metric sensitive to the volume fraction of axons. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370560PMC
January 2019
1 Read

Prenatal lead exposure impacts cross-hemispheric and long-range connectivity in the human fetal brain.

Neuroimage 2019 Feb 7;191:186-192. Epub 2019 Feb 7.

Department of Psychology, Michigan State University, East Lansing, MI, USA.

Lead represents a highly prevalent metal toxicant with potential to alter human biology in lasting ways. A population segment that is particularly vulnerable to the negative consequences of lead exposure is the human fetus, as exposure events occurring before birth are linked to varied and long-ranging negative health and behavioral outcomes. An area that has yet to be addressed is the potential that lead exposure during pregnancy alters brain development even before an individual is born. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193010
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http://dx.doi.org/10.1016/j.neuroimage.2019.02.017DOI Listing
February 2019
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Neural correlates of online cooperation during joint force production.

Neuroimage 2019 Feb 7;191:150-161. Epub 2019 Feb 7.

Division of Cerebral Integration, National Institute for Physiological Science, Okazaki, Japan. Electronic address:

During joint action, two or more persons depend on each other to accomplish a goal. This mutual recursion, or circular dependency, is one of the characteristics of cooperation. To evaluate the neural substrates of cooperation, we conducted a hyperscanning functional MRI study in which 19 dyads performed a joint force-production task. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.003DOI Listing
February 2019

Imaging beta amyloid aggregation and iron accumulation in Alzheimer's disease using quantitative susceptibility mapping MRI.

Neuroimage 2019 Feb 7;191:176-185. Epub 2019 Feb 7.

Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA. Electronic address:

Beta amyloid is a protein fragment snipped from the amyloid precursor protein (APP). Aggregation of these peptides into amyloid plaques is one of the hallmarks of Alzheimer's disease. MR imaging of beta amyloid plaques has been attempted using various techniques, notably with T2* contrast. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.019DOI Listing
February 2019
5 Reads

Exploring the limits of network topology estimation using diffusion-based tractography and tracer studies in the macaque cortex.

Neuroimage 2019 Feb 7;191:81-92. Epub 2019 Feb 7.

The Centre for Functional and Metabolic Mapping, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.

Reconstructing the anatomical pathways of the brain to study the human connectome has become an important endeavour for understanding brain function and dynamics. Reconstruction of the cortico-cortical connectivity matrix in vivo often relies on noninvasive diffusion-weighted imaging (DWI) techniques but the extent to which they can accurately represent the topological characteristics of structural connectomes remains unknown. We addressed this question by constructing connectomes using DWI data collected from macaque monkeys in vivo and with data from published invasive tracer studies. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.018DOI Listing
February 2019

Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives.

Neuroimage Clin 2019 Jan 29;22:101695. Epub 2019 Jan 29.

Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Objectives: So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy controls (HC).

Methods: 3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected FR and 29 HC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582193004
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http://dx.doi.org/10.1016/j.nicl.2019.101695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370861PMC
January 2019
1 Read

The structural brain correlates of callous-unemotional traits in incarcerated male adolescents.

Neuroimage Clin 2019 Jan 30;22:101703. Epub 2019 Jan 30.

The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA; Department of Psychology, University of New Mexico, Albuquerque, NM, USA.

Youth with severe conduct problems impose a significant cost on society by engaging in high levels of antisocial and aggressive behavior. Within this group, adolescents with high levels of callous- unemotional traits have been found to exhibit more severe and persistent patterns of antisocial behavior than youth with severe conduct problems but normative levels of callous-unemotional traits. Existing neuroimaging studies, along with theoretical accounts of psychopathology, suggest that dysfunction within the paralimbic cortex and limbic system may underlie elevated levels of callous-unemotional traits. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370859PMC
January 2019

Neurophysiological markers of network dysfunction in neurodegenerative diseases.

Neuroimage Clin 2019 Feb 2;22:101706. Epub 2019 Feb 2.

Academic Unit of Neurology, Trinity Biomedical Sciences Institute, 152-160 Pearse St., Trinity College Dublin, The University of Dublin, Ireland. Electronic address:

There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, its use is limited by poor temporal resolution, cost and confounding vascular parameters. By contrast, electrophysiological (e. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370863PMC
February 2019

Attention modulates event-related spectral power in multisensory self-motion perception.

Neuroimage 2019 Feb 7;191:68-80. Epub 2019 Feb 7.

Psychology, Neuroscience & Behaviour, Science, McMaster University, Hamilton, Ontario, Canada. Electronic address:

Humans integrate visual and physical (vestibular and proprioceptive) cues to motion during self-motion perception. Theta and alpha-band oscillations have been associated with the processing of visual motion (e.g. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.015DOI Listing
February 2019

Multi-atlas tool for automated segmentation of brain gray matter nuclei and quantification of their magnetic susceptibility.

Neuroimage 2019 Feb 6. Epub 2019 Feb 6.

Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Quantification of tissue magnetic susceptibility using MRI offers a non-invasive measure of important tissue components in the brain, such as iron and myelin, potentially providing valuable information about normal and pathological conditions during aging. Despite many advances made in recent years on imaging techniques of quantitative susceptibility mapping (QSM), accurate and robust automated segmentation tools for QSM images that can help generate universal and sharable susceptibility measures in a biologically meaningful set of structures are still not widely available. In the present study, we developed an automated process to segment brain nuclei and quantify tissue susceptibility in these regions based on a susceptibility multi-atlas library, consisting of 10 atlases with T1-weighted images, gradient echo (GRE) magnitude images and QSM images of brains with different anatomic patterns. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.016DOI Listing
February 2019
2 Reads

The emergence of long-range language network structural covariance and language abilities.

Neuroimage 2019 Feb 7;191:36-48. Epub 2019 Feb 7.

Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Language skills increase as the brain matures. Language processing, especially the comprehension of syntactically complex sentences, is supported by a brain network involving functional interactions between left inferior frontal and left temporal regions in the adult brain, with reduced functional interactions in children. Here, we examined the gray matter covariance of the cortical thickness network relevant for syntactic processing in relation to language abilities in preschool children (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193010
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http://dx.doi.org/10.1016/j.neuroimage.2019.02.014DOI Listing
February 2019
3 Reads

Neural responses to heartbeats distinguish self from other during imagination.

Neuroimage 2019 Feb 7;191:10-20. Epub 2019 Feb 7.

Laboratoire de Neurosciences Cognitives et Computationnelles, Inserm, Ecole Normale Supérieure, PSL University, Paris, France.

Imagination is an internally-generated process, where one can make oneself or other people appear as protagonists of a scene. How does the brain tag the protagonist of an imagined scene as being oneself or someone else? Crucially, during imagination, neither external stimuli nor motor feedback are available to disentangle imagining oneself from imagining someone else. Here, we test the hypothesis that an internal mechanism based on the neural monitoring of heartbeats could distinguish between self and other. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.012DOI Listing
February 2019

Dysfunction of attention switching networks in amyotrophic lateral sclerosis.

Neuroimage Clin 2019 Feb 2;22:101707. Epub 2019 Feb 2.

Academic Unit of Neurology, Trinity College Dublin, The University of Dublin, Ireland. Electronic address:

Objective: To localise and characterise changes in cognitive networks in Amyotrophic Lateral Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms.

Rationale: The MMN waveform has an increased average delay in ALS. MMN has been attributed to change detection and involuntary attention switching. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582193005
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http://dx.doi.org/10.1016/j.nicl.2019.101707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365983PMC
February 2019
5 Reads

Arterial spin labelling and diffusion-weighted imaging in paediatric brain tumours.

Neuroimage Clin 2019 Jan 29;22:101696. Epub 2019 Jan 29.

Developmental Imaging & Biophysics Section, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom.

Background: Diffusion- and perfusion-weighted MRI are valuable tools for measuring the cellular and vascular properties of brain tumours. This has been well studied in adult patients, however, the biological features of childhood brain tumours are unique, and paediatric-focused studies are less common. We aimed to assess the diagnostic utility of apparent diffusion coefficient (ADC) values derived from diffusion-weighted imaging (DWI) and cerebral blood flow (CBF) values derived from arterial spin labelling (ASL) in paediatric brain tumours. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365981PMC
January 2019

On the analysis of rapidly sampled fMRI data.

Neuroimage 2019 Feb 5. Epub 2019 Feb 5.

Department of Radiology, Stanford University, Stanford, CA, USA.

Recent advances in parallel imaging and simultaneous multi-slice techniques have permitted whole-brain fMRI acquisitions at sub-second sampling intervals, without significantly sacrificing the spatial coverage and resolution. Apart from probing brain function at finer temporal scales, faster sampling rates may potentially lead to enhanced functional sensitivity, owing possibly to both cleaner neural representations (due to less aliased physiological noise) and additional statistical benefits (due to more degrees of freedom for a fixed scan duration). Accompanying these intriguing aspects of fast acquisitions, however, confusion has also arisen regarding (1) how to preprocess/analyze these fast fMRI data, and (2) what exactly is the extent of benefits with fast acquisitions, i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193009
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http://dx.doi.org/10.1016/j.neuroimage.2019.02.008DOI Listing
February 2019
4 Reads
6.357 Impact Factor

Context-dependent modulation of cognitive control involves different temporal profiles of fronto-parietal activity.

Neuroimage 2019 Feb 5;189:755-762. Epub 2019 Feb 5.

Department of Experimental Psychology, Ghent University, 9000, Ghent, Belgium.

To efficiently deal with quickly changing task demands, we often need to organize our behaviour on different time scales. For example, to ignore irrelevant and select relevant information, cognitive control might be applied in reactive (short time scale) or proactive (long time scale) mode. These two control modes play a pivotal role in cognitive-neuroscientific theorizing but the temporal dissociation of the underlying neural mechanisms is not well established empirically. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.004DOI Listing
February 2019

Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure.

Neuroimage 2019 Feb 5;189:793-803. Epub 2019 Feb 5.

Experimental Psychology, University of Bristol, 12a Priory Road, BS8 1TU, UK.

Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated the hypothesis that systemic inflammation would mediate central obesity related effects on limbic tissue microstructure in 166 asymptomatic individuals (38-71 years old). Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.007DOI Listing
February 2019