671 results match your criteria Neuro-ophthalmic Manifestations of Vascular Eye Diseases


Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography.

Korean J Ophthalmol 2018 Dec;32(6):506-516

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.

Purpose: We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye.

Methods: We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 μm, while group B had a size of ≥400 μm. Read More

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December 2018
3 Reads

Neuro-ophthalmologic disorders following concussion.

Handb Clin Neurol 2018 ;158:145-152

Department of Neurology, NYU School of Medicine, New York, NY, United States; Ophthalmology, NYU School of Medicine, New York, NY, United States. Electronic address:

Visual symptoms, such as photophobia and blurred vision, are common in patients with concussion. Such symptoms may be accompanied by abnormalities of specific eye movements, such as saccades and convergence, or accommodation deficits. The high frequency of visual involvement in concussion is not surprising, since more than half of the brain's pathways are dedicated to vision and eye movement control. Read More

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January 2018
1 Read

Neuro-Ophthalmic Disorders in Pregnancy.

Neurol Clin 2019 Feb;37(1):85-102

Department of Neurology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA; Department of Ophthalmology, Massachusetts Eye and Ear, 243 Charles Street, Boston, MA 02114, USA. Electronic address:

The physiologic changes that accompany pregnancy can have important implications for neuro-ophthalmic disease. This article discusses pregnancy-related considerations for meningioma, pituitary disorders, demyelinating disease, myasthenia gravis, thyroid eye disease, idiopathic intracranial hypertension, cerebral venous sinus thrombosis, stroke, migraine, and cranial neuropathies. The article also details the potential neuro-ophthalmic complications of preeclampsia and eclampsia and reviews the use of common diagnostic studies during pregnancy. Read More

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February 2019
3 Reads

Coagulative necrotic pituitary adenoma apoplexy: A retrospective study of 21 cases from a large pituitary center in China.

Pituitary 2018 Nov 2. Epub 2018 Nov 2.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, People's Republic of China.

Purpose: Coagulative necrotic pituitary apoplexy (CNPA) is a clinical entity with unique intraoperative and histopathological manifestations. We aimed to improve the knowledge of this rare disease through the largest case series published to date.

Methods: A retrospective review of 21 CNPA patients was performed from among 5095 patients who underwent surgery for pituitary adenomas at a single institution between January 2009 and June 2017. Read More

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November 2018
4 Reads

Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis.

BMC Ophthalmol 2018 Oct 26;18(1):278. Epub 2018 Oct 26.

Ocular Oftalmologia, Vitória, Brazil.

Background: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. Read More

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October 2018
7 Reads

Proceedings of the Neuro-Ophthalmology Program of the 33rd Asia-Pacific Academy of Ophthalmology Congress, Hong Kong, 8-11 February 2018.

Neuroophthalmology 2018 Oct 23;42(5):326-333. Epub 2018 May 23.

Department of Ophthalmology, Hong Kong Eye Hospital, Kowloon, Hong Kong.

The 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress was held on Feb 8-11, 2018 in Hong Kong. This report summarized the highlights of the neuro-ophthalmology program of the Congress, including the scientific symposia (invited and submitted) and the social activities. Read More

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October 2018
2 Reads

Study of Optimal Perimetric Testing in Children (OPTIC): evaluation of kinetic approaches in childhood neuro-ophthalmic disease.

Br J Ophthalmol 2018 Sep 19. Epub 2018 Sep 19.

Life Course Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK

Aims: We compared feasibility, quality and outcomes of visual field (VF) testing in children with neuro-ophthalmic disease between the discontinued 'gold-standard' Goldmann and Octopus perimeters.

Methods: Children with neuro-ophthalmic disease, attending Great Ormond Street Hospital, London, were assessed using standardised protocols by one examiner in a single sitting, using Goldmann and Octopus kinetic perimetry. Outputs were classified to compare severity of loss and defect type. Read More

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September 2018
6 Reads

Pupillary light reaction in preclinical Alzheimer's disease subjects compared with normal ageing controls.

Br J Ophthalmol 2018 Sep 11. Epub 2018 Sep 11.

Department of Ophthalmology and Visual Sciences, Washington University in St Louis School of Medicine, St. Louis, Missouri, USA.

Background/aims: We wished to determine whether the pupillary light reaction can differentiate preclinical Alzheimer's disease (AD) subjects from normal ageing controls. We performed a prospective study evaluating the pupillary light reaction in a cohort of well-characterised subjects with preclinical AD versus normal ageing controls.

Methods: We recruited 57 subjects from our institution's Memory and Aging Project, part of our Alzheimer's Disease Research Center. Read More

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September 2018

Neuro-ophthalmic complications of IgG4-related disease.

Curr Opin Ophthalmol 2018 Nov;29(6):485-494

Department of Neuro-Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, USA.

Purpose Of Review: IgG4-related disease (IgG4-RD) is increasingly recognized as a fibroinflammatory disease with a plethora of organ-specific manifestations but a particular predilection for head and neck tissues, including the nervous system. This review discusses general features and organ-specific presentations of IgG4-RD as well as treatment considerations, particularly emphasizing features of neuro-ophthalmic interest.

Recent Findings: IgG4-RD is emerging as a common cause of several fibroinflammatory disorders in the head and neck that were previously considered idiopathic, such as sclerosing orbital pseudotumor, orbital myositis, hypophysitis, and hypertrophic pachymeningitis. Read More

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November 2018
9 Reads

Neurological and Ophthalmological Manifestations of Varicella Zoster Virus.

J Neuroophthalmol 2018 Sep 1. Epub 2018 Sep 1.

Department of Neurological Sciences (SK, LNJ), University of Nebraska Medical Center, Omaha, Nebraska; Stanley M Truhlsen Eye Institute (SK), University of Nebraska Medical Center, Omaha, Nebraska; and Department of Neurology (JRB), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Approximately 1 million new cases of herpes zoster (HZ) occur in the United States annually, including 10%-20% with herpes zoster ophthalmicus (HZO). Postherpetic neuralgia, a debilitating pain syndrome occurs in 30% HZ, whereas 50% HZO develop ophthalmic complications. Diplopia from cranial nerve palsy occurs in less than 30% HZO, whereas optic neuropathy is seen in less than 1% HZO. Read More

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September 2018
7 Reads

Bilateral oculomotor ocular neuromyotonia: a case report.

BMC Neurol 2018 Sep 3;18(1):137. Epub 2018 Sep 3.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.

Background: Ocular neuromyotonia (ONM) is characterized by episodic diplopia, which is usually triggered by prolonged eccentric gaze of the affected extraocular muscles. The spell is characterized by involuntary, occasionally painful, sustained contraction of one or more extraocular muscles innervated by the oculomotor, trochlear, or abducens nerve. ONM usually occurs as a late consequence of radiotherapy around the parasellar area, although idiopathic cases have been reported. Read More

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September 2018
7 Reads

Meta-analysis of genotype-phenotype analysis of OPA1 mutations in autosomal dominant optic atrophy.

Mitochondrion 2018 Aug 27. Epub 2018 Aug 27.

Division of Genetics and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA, USA. Electronic address:

Autosomal Dominant Optic Atrophy (ADOA) is a neuro-ophthalmic disease characterized by progressive bilateral vision loss, pallor of the optic disc, central vision loss, and impairment of color vision. Additionally, a small percentage of patients experience hearing loss and ataxia, while recent studies suggest disruption of cardiac and neuromuscular functions. In order to obtain a better understanding of the genotype-phenotype correlation of the various mutations in the optic atrophy 1 (OPA1) gene, we obtained both clinical and genetic information of ADOA patients from published reports. Read More

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August 2018
14 Reads

Eye damage due to cosmetic ultrasound treatment: a case report.

BMC Ophthalmol 2018 Aug 29;18(1):214. Epub 2018 Aug 29.

Eye Center, Wuhan University Renmin Hospital, 238 Jie Fang Road, Wu Chang District, Wuhan, 430060, China.

Background: Rejuvenation of aging eyelids is one of cosmetic changes to the individual to create the appearance of youth. Tightening treatment of eyelid by ultrasonic heat could possibly develop acute eye injury, including acute increase of IOP, cataract and rarely myopia.

Case Presentation: A case report of rejuvenation tightening treatment caused eye injury with 6 months' follow-up. Read More

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August 2018
16 Reads

Imaging in neuro-ophthalmology in the context of value-based care.

Curr Opin Ophthalmol 2018 Nov;29(6):503-507

Massachusetts Eye and Ear Infirmary, Boston, USA.

Purpose Of Review: Neuro-ophthalmic imaging is an invaluable tool for clinical decision-making and has evolved rapidly. At the same time, both imaging utilization and healthcare costs have skyrocketed, and concern for imaging overuse has become a salient topic. This article gives an overview of the current state of neuro-ophthalmic imaging from a value-based medicine lens and discusses recent neuro-ophthalmic advancements in OCT with these considerations in mind. Read More

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November 2018
9 Reads

Initial Impairment and Recovery of Vision-Related Functioning in Participants With Acute Optic Neuritis From the RENEW Trial of Opicinumab.

J Neuroophthalmol 2018 Aug 7. Epub 2018 Aug 7.

Department of Value and Access (JP), Biostatistics (YC, LX), and Clinical Development (DC), Biogen, Cambridge, Massachusetts; and Departments of Neurology, Population Health, and Ophthalmology (LB and SG), New York University School of Medicine, New York, New York.

Background: Leucine-rich repeat and immunoglobulin domain-containing Nogo receptor-interacting protein 1(LINGO-1 is a key suppressor of oligodendrocyte differentiation and axonal remyelination and regeneration. This analysis evaluated the potential benefit of opicinumab, a human monoclonal antibody against LINGO-1, vs placebo on exploratory clinical endpoints of patient-reported vision-related functioning and high-contrast visual acuity (HCVA) in RENEW participants with acute optic neuritis (AON).

Methods: Participants were randomized to 100 mg/kg opicinumab intravenous or placebo every 4 weeks (6 infusions). Read More

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August 2018
1 Read

Gaze-Contingent Flicker Pupil Perimetry Detects Scotomas in Patients With Cerebral Visual Impairments or Glaucoma.

Front Neurol 2018 10;9:558. Epub 2018 Jul 10.

Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, Netherlands.

The pupillary light reflex is weaker for stimuli presented inside as compared to outside absolute scotomas. Pupillograph perimetry could thus be an objective measure of impaired visual processing. However, the diagnostic accuracy in detecting scotomas has remained unclear. Read More

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The Role of Optical Coherence Tomography in the Acute Management of Neuro-Ophthalmic Diseases.

Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):265-270. Epub 2018 Jun 25.

Hong Kong Eye Hospital, Hong Kong.

Optical coherence tomography (OCT) can provide high-speed and high-resolution images of the anatomical structures of the optic nerve head and macula. However, in neuro-ophthalmic conditions that present acutely, structural changes lag functional deficits, and the role of OCT in the acute setting has been challenged. This review aims to summarize the recent literature and evidence supporting the use of OCT in the acute management of some common neuro-ophthalmic scenarios, including the differential diagnosis of optic disc swelling, and in patients with suspected papilledema, optic neuritis, ischemic optic neuropathies, and Leber hereditary optic neuropathy. Read More

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[Preoperative and postoperative ophthalmic symptoms in patients with space-occupying lesions of the midbrain and pineal region].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(3):42-47

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047.

The most common clinical manifestations of space-occupying lesions of the midbrain and pineal region are oculomotor and pupil disorders and ophthalmoscopic signs of intracranial hypertension.

Purpose: To identify patterns of neuro-ophthalmic symptoms before and after surgical treatment in patients with space-occupying lesions of the midbrain and pineal region.

Material And Methods: We analyzed neurological symptoms in 231 patients with space-occupying lesions of the midbrain and pineal region before and after surgical treatment. Read More

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January 2018
7 Reads

Laquinimod protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model.

J Neuroinflammation 2018 Jun 14;15(1):183. Epub 2018 Jun 14.

Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892, Bochum, Germany.

Background: The oral immunomodulatory agent laquinimod is currently evaluated for multiple sclerosis (MS) treatment. Phase II and III studies demonstrated a reduction of degenerative processes. In addition to anti-inflammatory effects, laquinimod might have neuroprotective properties, but its impact on the visual system, which is often affected by MS, is unknown. Read More

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June 2018
2 Reads

Patients With Migraine Have Substantial Reductions in Measures of Visual Quality of Life.

Headache 2018 Jul 7;58(7):1007-1013. Epub 2018 Jun 7.

Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Salt Lake City, UT, USA.

Objective: Migraine is associated with several important visual symptoms, during both acute attacks and headache-free intervals. The purpose of this investigation was to use validated vision-related quality of life instruments to assess the effect of migraine on visual quality of life.

Background: Many migraineurs experience visual aura, increased photophobia during and between headache attacks, and increased symptoms of dry eye with structural changes in corneal nerve endings. Read More

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July 2018
11 Reads

[Current diagnosis and treatment of idiopathic intracranial hypertension].

Ideggyogy Sz 2017 Sep;70(9-10):321-332

Országos Klinikai Idegtudományi Intézet, Budapest.

Background And Purpose: Idiopathic intracranial hypertension is cha-racterized by raised intracranial pressure of unknown origin, leading to persisting visual loss if left untreated. Purpose - We assessed timing of surgery, and the efficacy and safety of ventriculo-peritoneal shunt.

Methods: Retrospective analysis of 65 patients treated at our Neuro-ophthalmology Clinic between 2009 and 2017. Read More

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September 2017
3 Reads

Necrotising scleritis, keratitis and uveitis in primary antiphospholipid syndrome.

BMJ Case Rep 2018 May 14;2018. Epub 2018 May 14.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Ocular manifestations of antiphospholipid syndrome typically include thromboembolic and neuro-ophthalmic complications. In this report we present a case of inflammation of the ocular coats in a patient diagnosed with antiphospholipid syndrome 16 years prior. We discuss management of the case and the possible aetiology of the rare association. Read More

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May 2018
4 Reads

The Outcomes of Pituitary Apoplexy with Conservative Treatment: Experiences at a Single Institution.

World Neurosurg 2018 Jul 27;115:e703-e710. Epub 2018 Apr 27.

Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objective: Pituitary apoplexy is an unpredictable complication caused by hemorrhage or infarction in a pituitary adenoma. We retrospectively analyzed the radiologic and clinical outcomes of patients with conservatively managed pituitary apoplexy.

Methods: A total of 32 patients who had undergone conservative treatment with high-dose corticosteroid replacement were enrolled in this study. Read More

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July 2018
2 Reads

Vertical diplopia and oscillopsia due to midbrain keyhole aqueduct syndrome associated with severe cough.

Am J Ophthalmol Case Rep 2018 Jun 15;10:128-131. Epub 2018 Feb 15.

Department of Ophthalmology, Stanford School of Medicine, 2452 Watson Court, Palo Alto, CA 94303-5353, USA.

Purpose: Midline structural defects in the neural axis can give rise to neuro-ophthalmic symptoms. We report a rare case of keyhole aqueduct syndrome presenting after two years of severe cough due to gastroesophageal reflux disease.

Observations: A 58-year-old woman with a 2-year history of daily, severe cough presented to the neuro-ophthalmology clinic with progressive diplopia and oscillopsia. Read More

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June 2018
4 Reads

An atypical case of neurosarcoidosis presenting with neovascular glaucoma.

J Ophthalmic Inflamm Infect 2018 Apr 18;8(1). Epub 2018 Apr 18.

Department of Ophthalmology, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium.

Background: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative.

Findings: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Read More

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April 2018
2 Reads

Automated achromatic perimetry.

Oman J Ophthalmol 2018 Jan-Apr;11(1):3-10

Department of Glaucoma and Anterior Segment, Regional Institute of Ophthalmology (RIO), Government Medical College, Amritsar, Punjab, India.

Visual field (VF) testing is an important diagnostic tool for Glaucoma. The current gold standard for VF testing is automated perimetry. This article is an attempt to familiarize the reader with components of an achromatic (white on white) automated perimetry printout. Read More

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Impact of the Elimination of Consultation Codes on Neuro-Ophthalmology in the United States.

J Neuroophthalmol 2018 Mar;38(1):4-6

Departments of Ophthalmology, Neurology, and Neurosurgery (PSS), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Departments of Ophthalmology and Neurosciences (LPF), Rutgers- New Jersey Medical School, Newark, New Jersey; and Department of Ophthalmology (VB), Emory University School of Medicine, Atlanta, Georgia.

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March 2018
1 Read

Correlations among multifocal electroretinography and optical coherence tomography findings in patients with Parkinson's disease.

Neurol Sci 2018 Mar 18;39(3):533-541. Epub 2018 Jan 18.

School of Medicine, Ophthalmology Department, Erciyes University, 38039, Kayseri, Turkey.

To assess the correlation between functional and anatomical evaluations with multifocal electroretinography (mfERG) and spectral-domain optical coherence tomography (SD-OCT) in patients with Parkinson's disease (PD). This cross-sectional study involved 116 eyes of 58 patients with PD and 30 age- and sex-matched control subjects. All study participants underwent a comprehensive neuro-ophthalmic examination, retinal single-layer thicknesses and volumes, and peripapillary retinal nerve fiber layer (pRNFL) measurements with SD-OCT, and the patients' mfERG recordings were evaluated. Read More

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March 2018
4 Reads

An unusual case of basilar artery aneurysm presenting with spastic quadriparesis.

BMJ Case Rep 2018 Jan 17;2018. Epub 2018 Jan 17.

Department of Neurology, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India.

Unruptured aneurysm usually presents with headache and neuro-ophthalmic features; when it ruptures, it presents with subarachnoid haemorrhage. Basilar artery aneurysm represents only 3-5% of cerebral aneurysms. Non-haemorrhagic symptoms and the signs of unruptured aneurysms are manifested as mass effect, thromboembolic phenomenon or epileptical attacks. Read More

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January 2018
2 Reads

Neuro-Ophthalmic Presentation of Neuro-Sweet Disease.

Neuroophthalmology 2017 Aug 15;41(4):202-206. Epub 2017 Mar 15.

Department of Neurological Sciences and Stanley Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Acute febrile neutrophilic dermatosis (Sweet syndrome) is a systemic inflammatory condition usually associated with autoimmune or neoplastic processes and characterised by inflammatory dermatologic lesions such as erythematous plaques and papules associated with fever and leukocytosis. Neurological and ophthalmological involvement is rare. The authors describe an unusual case of Sweet syndrome associated with microscopic polyangiitis presenting with papilloedema, anterior uveitis, and skin rash. Read More

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August 2017
5 Reads

Retinitis Pigmentosa Sine Pigmento Mimicking a Chiasm Disease.

Neuroophthalmology 2017 Aug 15;41(4):198-201. Epub 2017 Mar 15.

Neuro-Ophthalmology Service, Department of Ophthalmology, Conegliano Hospital, Conegliano (TV), Italy.

A 75-year-old woman presented to her ophthalmologist complaining of visual loss for several years. The ophthalmic examination was remarkable for a bitemporal visual field defect. Magnetic resonance imaging (MRI) scan of the brain was normal without evidence of chiasm compression. Read More

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August 2017
8 Reads

Changes in Central Macular Thickness and Retinal Nerve Fiber Layer Thickness in Eyes with Vogt-Koyanagi-Harada Disease: A 2-Year Follow-Up Study.

Ophthalmologica 2018 16;239(2-3):143-150. Epub 2018 Jan 16.

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.

Purpose: To investigate the central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness in eyes with Vogt-Koyanagi-Harada (VKH) disease associated with optic disc swelling and serous retinal detachment through a 24-month follow-up period.

Methods: We prospectively investigated 28 eyes of 14 treatment-naïve patients with acute VKH disease associated with optic disc swelling and serous retinal detachment and 30 eyes of 15 normal individuals to compare changes in the CMT and average RNFL thickness.

Results: The CMT was significantly lower in the eyes of the VKH group at 12 and 24 months. Read More

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April 2018
5 Reads

Neuro-Ophthalmic Manifestations of Pituitary Carcinoma.

J Neuroophthalmol 2018 Sep;38(3):339-341

Baylor College of Medicine (EC, RS, PCB, AGL), Houston, Texas; Department of Ophthalmology (SVS, AS, PCB, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Department of Pathology (JOG, PCB), Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (PCB, AGL), Weill Cornell Medicine, New York City, New York; Section of Ophthalmology (AGL), UT MD Anderson Cancer Center, Houston, Texas; Department of Ophthalmology (AGL), Baylor College of Medicine, Houston, Texas; Department of Ophthalmology (AGL), University of Iowa, Iowa City, Iowa; and Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas.

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September 2018
1 Read

A Profile of Neuro-Ophthalmic Practice Around the World.

Authors:
Larry P Frohman

J Neuroophthalmol 2018 Mar;38(1):47-51

Rutgers-New Jersey Medical School, Newark, New Jersey.

Background: To compare contrast neuro-ophthalmic practice in various countries, an 18-question survey was sent to the international North American Neuro-Ophthalmology Society (NANOS) members in the spring of 2016.

Methods: At least 1 NANOS member was contacted for each non-US nation in the NANOS membership roster. If there were multiple NANOS members from 1 country, multiple were contacted. Read More

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March 2018
1 Read

Reversal of carotid dissection-induced ocular and cerebral ischemia by stenting.

Am J Ophthalmol Case Rep 2017 Sep 18;7:50-54. Epub 2017 May 18.

Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, United States.

Purpose: To present an example of how close clinical monitoring of a patient with acute Horner syndrome from carotid artery dissection may be critical in reversing neurologic dysfunction.

Observations: A patient whose initial neuro-ophthalmic manifestation was Horner syndrome, but who evolved over 14 days to display transient monocular vision loss, ipsilateral ocular ischemic syndrome, and episodic contralateral hemiparesis. Digital subtraction angiography demonstrated progressive ipsilateral carotid occlusion with lack of collateral flow. Read More

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September 2017
3 Reads

Eye movement abnormalities in AQP4-IgG positive neuromyelitis optica spectrum disorder.

J Neurol Sci 2018 Jan 24;384:91-95. Epub 2017 Nov 24.

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

Background And Purpose: Neuromyelitis optica spectrum disorder (NMOSD) has been recognized as a disease characterized by severe visual afferent impairment. Abnormal eye movements, as the other important neuro-ophthalmic manifestation of NMOSD, were commonly overlooked. The aim of our study was to describe the ocular motor manifestations of AQP4-IgG positive NMOSD patients, and explore the value of eye movement abnormalities in the evaluation of the disabled disease. Read More

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January 2018
6 Reads

Advances in Neuro-Ophthalmic Imaging.

Semin Neurol 2017 10 5;37(5):566-579. Epub 2017 Dec 5.

Division of Neuro-Ophthalmology, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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October 2017

Neuro-Ophthalmology at a Tertiary Eye Care Centre in India.

J Neuroophthalmol 2018 Sep;38(3):308-311

Strabismus and Neuro-ophthalmology Services, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Background: Neuro-ophthalmology as a specialty is underdeveloped in India. The aim of our study was to determine the spectrum and profile of patients presenting to a tertiary eye care center with neuro-ophthalmic disorders.

Methods: A retrospective hospital-based study was conducted, and records of all patients seen at the neuro-ophthalmology clinic of Dr. Read More

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September 2018
8 Reads

Characterization of Charcot-Marie-Tooth optic neuropathy.

J Neurol 2017 12 23;264(12):2431-2435. Epub 2017 Oct 23.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Varying degrees of optic neuropathy can be seen in patients with Charcot-Marie-Tooth (CMT) disease. To define and characterize the extent of optic neuropathy in patients with CMT2A and CMT1A, two patients from both sub-classifications were evaluated. All patients underwent complete neuro-ophthalmic examinations, and optical coherence (OCT) measurements of the retinal nerve fiber layer (RNFL) and ganglion cell layer complex (GCC) were obtained, along with pattern visual evoked potential (VEP) and pattern electroretinogram (ERG) recordings. Read More

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December 2017
3 Reads

Neuro-ophthalmic side effects of molecularly targeted cancer drugs.

Eye (Lond) 2018 02 20;32(2):287-301. Epub 2017 Oct 20.

Department of Medicine, Division of Medical Oncology, Duke Cancer Center, Durham, NC, USA.

The past two decades has been an amazing time in the advancement of cancer treatment. Molecularly targeted therapy is a concept in which specific cellular molecules (overexpressed, mutationally activated, or selectively expressed proteins) are manipulated in an advantageous manner to decrease the transformation, proliferation, and/or survival of cancer cells. In addition, increased knowledge of the role of the immune system in carcinogenesis has led to the development of immune checkpoint inhibitors to restore and enhance cellular-mediated antitumor immunity. Read More

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February 2018
4 Reads

Optical Coherence Tomography in the Management of Skull Base Fibrous Dysplasia with Optic Nerve Involvement.

World Neurosurg 2018 Jan 13;109:e546-e553. Epub 2017 Oct 13.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Fibrous dysplasia (FD) of the skull base can manifest with optic nerve compression. As most patients initially do not experience vision loss, controversy exists whether to proceed with prophylactic surgical decompression or elect for conservative observation. Optical coherence tomography (OCT), a physiologic imaging modality widely used to assess the condition of the retinal nerve fiber layer (RNFL), has been useful in monitoring compressive tumors on the optic nerve. Read More

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January 2018
10 Reads

Neuro-ophthalmic manifestations of cerebrovascular accidents.

Curr Opin Ophthalmol 2017 Nov;28(6):564-572

aDepartment of Ophthalmology bDepartment of Neurology cDepartment of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado, USA.

Purpose Of Review: Ocular functions can be affected in almost any type of cerebrovascular accident (CVA) creating a burden on the patient and family and limiting functionality. The present review summarizes the different ocular outcomes after stroke, divided into three categories: vision, ocular motility, and visual perception. We also discuss interventions that have been proposed to help restore vision and perception after CVA. Read More

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November 2017
5 Reads

Discrepancies between vascular and systemic inflammation in large vessel vasculitis: an important problem revisited.

Rheumatology (Oxford) 2018 05;57(5):784-790

Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey.

A lack of absolute correlation between systemic inflammation parameters and ongoing vascular disease activity is an important problem in some patients with large vessel vasculitis, especially Takayasu arteritis (TAK). Systemic and vascular wall inflammation in TAK are obviously interrelated, but sometimes they may act independently. There are clear discrepancies between these two types of inflammation, including cytokine patterns and responses to treatment. Read More

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May 2018
48 Reads

Neuro-ophthalmology in the Horse.

Authors:
Kathern E Myrna

Vet Clin North Am Equine Pract 2017 Dec 27;33(3):541-549. Epub 2017 Sep 27.

Department of Small Animal Medicine and Surgery, Veterinary Medical Center, University of Georgia, 2200 College Station Road, Athens, GA 30602, USA. Electronic address:

This article provides a brief, clinically relevant review of neurologic disorders of the eye. A description of the neuro-ophthalmic examination is provided. Stepwise descriptions of the most common neuro-ophthalmic abnormalities are provided along with common rule outs. Read More

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December 2017
3 Reads

Neuro-Ophthalmic Manifestations of Pediatric Neurodegenerative Disease.

Authors:
Gena Heidary

J Neuroophthalmol 2017 09;37 Suppl 1:S4-S13

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

The topic of pediatric neurodegenerative disease is broad and ever expanding. Children who suffer from neurodegenerative disease often have concomitant visual dysfunction. Neuro-ophthalmologists may become involved in clinical care to identify corroborating eye findings when a specific condition is suspected, to monitor for disease progression, and in some cases, to assess treatment efficacy. Read More

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September 2017
4 Reads

Ophthalmic and neuro-ophthalmic manifestations of sarcoidosis.

Curr Opin Ophthalmol 2017 Nov;28(6):587-594

aDepartment of Ophthalmology bDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

Purpose Of Review: Sarcoidosis is a multisystemic inflammatory disease that commonly affects the eye and less often the neuro-ophthalmic pathways. The manifestations can be quite variable but can have characteristic signs and clinical features. This review provides a comprehensive overview of the various ocular and neuro-ophthalmic manifestations of sarcoidosis, emerging diagnostic measures and approach to treatment. Read More

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November 2017
11 Reads

Intracranial Aneurysms of Neuro-Ophthalmologic Relevance.

J Neuroophthalmol 2017 12;37(4):421-439

Department of Ophthalmology and Vision Science (JAM), University of Toronto, Toronto, Ontario, Canada Departments of Ophthalmology and Neurology (NJN, VB) and Neurological Surgery (DB, NJN), Emory University School of Medicine, Atlanta, Georgia.

Background: Intracranial saccular aneurysms are acquired lesions that often present with neuro-ophthalmologic symptoms and signs. Recent advances in neurosurgical techniques, endovascular treatments, and neurocritical care have improved the optimal management of symptomatic unruptured aneurysms, but whether the chosen treatment has an impact on neuro-ophthalmologic outcomes remains debated.

Evidence Acquisition: A review of the literature focused on neuro-ophthalmic manifestations and treatment of intracranial aneurysms with specific relevance to neuro-ophthalmologic outcomes was conducted using Ovid MEDLINE and EMBASE databases. Read More

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December 2017
7 Reads

MRI-derived diffusion parameters in the human optic nerve and its surrounding sheath during head-down tilt.

NPJ Microgravity 2017 21;3:18. Epub 2017 Jun 21.

Division of Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.

More than half of astronauts present with significant neuro-ophthalmic findings during 6-month missions onboard the International Space Station. Although the underlying cause of this Microgravity Ocular Syndrome is currently unknown, alterations in cerebrospinal fluid dynamics within the optic nerve sheath may play a role. In the presented study, diffusion tensor imaging was used to assess changes in diffusivity of the optic nerve and its surrounding sheath during head-down tilt, a ground-based model of microgravity. Read More

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June 2017
12 Reads

Gene Therapy for Leber Hereditary Optic Neuropathy: Low- and Medium-Dose Visual Results.

Ophthalmology 2017 11 21;124(11):1621-1634. Epub 2017 Jun 21.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Purpose: To determine the effects of AAV2(Y444,500,730F)-P1ND4v2 in patients with Leber hereditary optic neuropathy (LHON).

Design: Prospective open-label, unilateral single-dose, intravitreal injection of AAV2(Y444,500,730F)-P1ND4v2 per participant.

Participants: Fourteen patients with visual loss and mutated G11778A mitochondrial DNA. Read More

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November 2017
10 Reads