3,605 results match your criteria Neuro-Ophthalmology [Journal]
Korean J Ophthalmol 2018 Dec;32(6):506-516
Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.
Purpose: We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye.
Methods: We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 μm, while group B had a size of ≥400 μm. Read More
Curr Opin Neurol 2018 Dec 12. Epub 2018 Dec 12.
Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston.
Purpose Of Review: To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH).
Recent Findings: The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified as having migraine. A larger proportion of those with IIH have a past medical history of migraine, compared with the general population, highlighting the importance of re-examining those who have a change or escalation in their headache. Read More
BMC Ophthalmol 2018 Dec 12;18(1):317. Epub 2018 Dec 12.
Neurology division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Background: This report highlights a rare case of simultaneous bilateral blindness due to posterior ischemic optic neuropathy. Typically, ophthalmic involvement in giant cell arteritis is monocular or sequential ischemia of the anterior portion of the optic nerve, and less frequently simultaneous.
Case Presentation: An 80-year-old Saudi male came with a history of simultaneous bilateral vision loss 5 days prior to presentation. Read More
Neuroophthalmology 2018 Dec 14;42(6):418-419. Epub 2018 Nov 14.
Neuroophthalmology 2018 Dec 25;42(6):414-417. Epub 2018 Apr 25.
Birmingham Neuro-ophthalmology Unit, University Hospital Birmingham, Edgbaston, Birmingham, UK.
The management of patients with cerebrospinal fluid disorders requires a multi-specialty approach involving specialists in neurosurgery, neurology, neuroradiology and neuro-ophthalmology. A symposium on CSF disorders was organised by the clinical and academic teams at University Hospitals Birmingham, United Kingdom. The meeting featured a synopsis of the latest scientific research on CSF disorders. Read More
Neuroophthalmology 2018 Dec 26;42(6):404-405. Epub 2018 Mar 26.
Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Bilateral intracavernous internal carotid artery aneurysms are rare. They are more common in elderly females and are associated with hypertension. We present the computed tomography angiography findings of an 81-year-old female with history of hypertension who came complaining of diplopia and headache. Read More
Neuroophthalmology 2018 Dec 5;42(6):402-403. Epub 2018 Feb 5.
Department of Haematology, Royal Free London Hospitals NHS Foundation Trust, London, UK.
Ocular features of Gaucher disease include gaze abnormalities, corneal clouding, ocular deposits and pigmentary changes in the macula. We report the presence of bilateral fovea sparing macular deposits in a 21-year-old woman with type 3 Gaucher disease. Macular deposits occur due to glucocerebroside accumulation within histiocytes and retinal deposits might correlate with the degree of systemic infiltration. Read More
Neuroophthalmology 2018 Dec 26;42(6):399-401. Epub 2018 Mar 26.
Department of Neurology, Ege University Medical School, İzmir, Turkey.
Oculogyric crisis (OGC) describes the clinical phenomenon of sustained dystonic, conjugate and typically upward deviation of the eyes. A few cases with downward or lateral deviations have been described.. Read More
Neuroophthalmology 2018 Dec 19;42(6):391-398. Epub 2018 Jun 19.
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
A 62-year-old male with a history of metastatic clear cell renal cell carcinoma (ccRCC) presented with decreased vision to 20/50 in the left eye. Fundus examination revealed an elevated, amelanotic mass lesion in the superotemporal macula, without involvement of the central macula by subretinal fluid or tumour. Given incongruity between the fundus findings and the degree of visual impairment, visual field testing was obtained, revealing a bitemporal hemianopia. Read More
Neuroophthalmology 2018 Dec 23;42(6):385-390. Epub 2018 May 23.
Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas, USA.
An 84-year-old woman presented with 3 months of vertical binocular diplopia and difficulty reading at near. She had a history of bilateral ophthalmic artery aneurysm repair involving use of muslin in the 1990s. The patient then developed bitemporal hemianopsia secondary to muslin-induced inflammation ("muslinoma") extending to the optic chiasm, which required surgical decompression. Read More
Neuroophthalmology 2018 Dec 25;42(6):367-384. Epub 2018 Apr 25.
Surgery & Anaesthesia, University of Otago Wellington, Wellington, New Zealand.
Optic nerve head drusen are benign acellular calcium concretions that usually form early in life, just anterior to the lamina cribrosa. Improving imaging using optical coherence tomography suggests they are common and may be present in many clinically normal discs. These drusen may change in appearance in early life, but are generally stable in adulthood, and may be associated with visual field defects, anterior ischaemic optic neuropathy, or rarer complications. Read More
Neuroophthalmology 2018 Dec 22;42(6):356-366. Epub 2018 May 22.
Department of Ophthalmology, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
The purpose of this study was to evaluate retinal thickness in different Xeroderma Pigmentosum (XP) complementation groups using spectral-domain optical coherence tomography (SD-OCT). This was a cross-sectional pilot study of 40 patients with XP. All patients had healthy-looking retinae and optic nerves on slit lamp biomicroscopy, and subtle or no neurological deficits. Read More
Neuroophthalmology 2018 Dec 25;42(6):349-355. Epub 2018 Apr 25.
Department of Neuro-ophthalmology, Moorfields Eye Hospital, London, United Kingdom.
The Pulfrich phenomenon, originally described in normal observers, is a treatable disorder of the perception of movement in depth in cases of unilateral or asymmetric optic neuropathy. Treatment is highly bespoke and factors influencing treatment response and failure remain unclear. We assessed 25 adults with suspected Pulfrich phenomenon due to a range of conditions in two tertiary referral centres. Read More
Neuroophthalmology 2018 Dec 11;42(6):343-348. Epub 2018 Sep 11.
Department of Ophthalmology, School of Medicine, Kitasato University, Sagamihara, Japan.
We investigated the diagnostic ability of a new criterion (simple temporal depression) for compressive lesions of the optic chiasm. The subjects were 124 eyes with compressive lesions of the optic chiasm. The controls were 84 eyes. Read More
Neuroophthalmology 2018 Dec 15;42(6):339-342. Epub 2018 Aug 15.
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.
We describe here a case series of six patients referred to the Neuro-ophthalmology service in Sheffield, UK with possible acute unilateral optic neuritis. Each patient had a triad of unilateral photophobia, ipsilateral retro-ocular pain, and ipsilateral loss of vision. All patients had normal ocular examinations and investigation findings with no objective structural or functional abnormalities identified. Read More
J Neuroophthalmol 2017 Sep;37(3):e6-e8
Departments of Ophthalmology and Neurology, Weill Medical College, New York, New York Weill Cornell Medicine Ophthalmology (MJD), New York, New York; and Department of Ohthalmology (JGO), Columbia University Medical Center, New York, New York.
Ann Indian Acad Neurol 2018 Oct-Dec;21(4):330-331
Department of Cornea and IOL, AG Eye Hospital, Trichy, Tamil Nadu, India.
Neuro Endocrinol Lett 2018 Oct 12;39(4):321-324. Epub 2018 Oct 12.
Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland.
Objectives: Myopia is associated with increased frequency of retinal degenerative changes which are the risk factors of intra- and postpartal ophthalmological complications. Aim of this study was to analyze the degenerative lesions detected in opthalmological examination (including peripheral retinal lesions) as a potential risk factors for eyes' status in terms of delivery in myopic women.
Material And Methods: 254 pregnant women affected with myopia underwent opthalmological examination as a screening method to examine retina. Read More
Anesthesiology 2019 Jan;130(1):12-30
Neuron 2018 Dec;100(5):1241-1251.e7
Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland; Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:
Large numbers of brain regions are active during behaviors. A high-resolution, brain-wide activity map could identify brain regions involved in specific behaviors. We have developed functional ultrasound imaging to record whole-brain activity in behaving mice at a resolution of ∼100 μm. Read More
Photodermatol Photoimmunol Photomed 2018 Dec 6. Epub 2018 Dec 6.
Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy.
Graves' orbitopathy (GO) and pre-tibial mixedema (PTM) are autoimmune manifestation sharing the same etiology and histopathology, a chronic course and a frustrating treatment. Current management include topical and systemic corticosteroid as first line therapy, whereas cyclosporine, surgery and orbital radiotherapy are indicated for severe GO with variable results and mostly temporary remissions. In particular, keratopath and photophobia, due to exophthalmos and eyelid retraction, impaired eye mobility and diplopia due to the compression of optic nerve and extra-ocular muscles are usually minimally modified, as well as leg plaques/nodules and lymphoedema. Read More
BMJ Open Ophthalmol 2018 31;3(1):e000165. Epub 2018 Oct 31.
Glaucoma and Neuro-Ophthalmology Department, FISABIO Oftalmologia, Valencia, Spain.
Objective: To compare prospectively intraocular pressure (IOP) results after deep sclerectomy (DS) using a topical short-term corticosteroid treatment (STCT, 1 month) versus a topical long-term and intense corticosteroid treatment (LTCT, 6 months) in a two2 year-follow-up.
Methods: Patients with medically uncontrolled open angle glaucoma were prospectively recruited and underwent a DS.
Results: We operated 45 eyes of 45 patients, 22 in STCT group and 23 in LTCT group. Read More
Pediatr Neurol 2018 Oct 16;87:9-10. Epub 2018 Aug 16.
Departments of Neurology and Ophthalmology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Division of Ophthalmology, Neuro-ophthalmology Service, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
Curr Opin Neurol 2018 Dec 3. Epub 2018 Dec 3.
Neuro-Ophthalmology, Emory Eye Center, Atlanta, Georgia, USA.
Curr Opin Neurol 2018 Dec 3. Epub 2018 Dec 3.
Department of Ophthalmology.
Purpose Of Review: This review summarizes the recent literature on diagnostic error relevant to the practice of neuro-ophthalmology, and evaluates the potential of increased access to neuro-ophthalmology as a means to decrease rates of diagnostic error, thereby reducing medical harm and spending on unnecessary tests and treatments.
Recent Findings: Despite medical advances, current research continues to show alarmingly high rates of diagnostic error. Research into diagnostic error shows that many of these errors can be traced to cognitive errors. Read More
Br J Ophthalmol 2018 Dec 4. Epub 2018 Dec 4.
Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China
Background/aims: To evaluate the status of myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in chronic relapsing inflammatory optic neuropathy (CRION) and investigate its different clinical characteristics and prognosis.
Methods: Patients diagnosed with CRION were recruited by the Neuro-ophthalmology Department of the Chinese People's Liberation Army General Hospital from December 2015 to April 2017. Based on antibody status, they were assigned to either the MOG-CRION or seronegative-CRION groups. Read More
Neuroophthalmology 2018 Oct 9;42(5):316-317. Epub 2018 Jan 9.
Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Lesions of the central nucleus of the third cranial nerve in midbrain leads to bilateral ptosis. We present a case of a 14 year old boy, who was found to have B/L non-correctable ptosis and medial rectus palsy. There was a ring enhancing lesion in the midbrain in contrast MRI which resolved with treatment. Read More
Neurourol Urodyn 2018 Nov 29. Epub 2018 Nov 29.
Neuro- and Spine Center, Hirslanden Klinik St. Anna, Lucerne, Switzerland.
Aims: Anterior lumbar interbody fusion procedures (ALIF) and total disc replacement (TDR) with anterior exposure of the lumbar spine entail a risk of a vascular injury and dysfunction of the sympathetic and parasympathetic nerves due to disturbance of the inferior and superior hypogastric plexus. While retrograde ejaculation is a known complication of the anterior spinal approach in males, post-operative sexual as well as urinary function in females has not yet been thoroughly investigated and was hence the aim of this study.
Methods: Fifteen female patients documented their sexual and urinary function preoperatively, 3 months and 6 months postoperatively, using the validated questionnaires FSFI (Female Sexual Function Index) and ICIQ (International Consultation of Incontinence Questionnaire). Read More
PLoS One 2018 29;13(11):e0208145. Epub 2018 Nov 29.
Doheny Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States of America.
Purpose: To assess the usefulness of spectral-domain optical coherence tomography (SD-OCT) peripapillary retinal nerve fiber layer (RNFL) thickness measurement in discriminating early phase optic disc edema (ODE) from pseudoedema (PODE).
Methods: Hospital-based, multicenter, cross-sectional study involving external patients referred for recent identification of "presumed ODE". Patients underwent SD-OCT optic nerve head (ONH) RNFL thickness measurement at their first evaluation. Read More
J R Coll Physicians Edinb 2018 Dec;48(4):323-327
Solihull Hospital, Lode Lane, Solihull B91 2JL, UK,
Behçet's disease is a chronic, relapsing, systemic inflammatory disease affecting the orogenital mucosa, eyes, joints, blood vessels, nervous system and intestines. The prevalence of neurological involvement varies geographically and can include psychiatric manifestations. Current evidence for a causal association between Behçet's disease and bipolar disorder is limited to a small number of case reports. Read More
J Med Genet 2018 Nov 28. Epub 2018 Nov 28.
NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Background: Very long-chain fatty acids (VLCFAs) are essential for functioning of biological membranes. ELOVL fatty acid elongase 1 catalyses elongation of saturated and monounsaturated C22-C26-VLCFAs. We studied two patients with a dominant mutation. Read More
PLoS One 2018 28;13(11):e0207525. Epub 2018 Nov 28.
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Purpose: The coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a commercially available technique for measuring blood flow, is capable to assess flicker-induced haemodynamic changes in the retinal and optic nerve head (ONH) circulation.
Methods: Twenty healthy subjects were included in this cross sectional study. Read More
Handb Clin Neurol 2018 ;158:145-152
Department of Neurology, NYU School of Medicine, New York, NY, United States; Ophthalmology, NYU School of Medicine, New York, NY, United States. Electronic address:
Visual symptoms, such as photophobia and blurred vision, are common in patients with concussion. Such symptoms may be accompanied by abnormalities of specific eye movements, such as saccades and convergence, or accommodation deficits. The high frequency of visual involvement in concussion is not surprising, since more than half of the brain's pathways are dedicated to vision and eye movement control. Read More
J Ophthalmic Vis Res 2018 Oct-Dec;13(4):518-519
Division of Neuro-Ophthalmology, Baylor College of Medicine, Houston, TX, USA.
Neurology 2018 Nov;91(22):e2104-e2105
From the Departments of Neurology (O.L., A.F.) and Neurology (Neuro-ophthalmology) (A.F.), Yale School of Medicine, New Haven, CT.
Med Sci (Basel) 2018 Nov 23;6(4). Epub 2018 Nov 23.
Department of Periodontology, K.L.E Society's Institute of Dental Sciences, Bangalore 560 022, Karnataka, India.
Periodontal disease (PD), a chronic inflammatory condition characterized by destruction of the supporting tissues of the teeth, increases the risk of complications in diabetics. Diabetic retinopathy (DR) is a microvascular complication of prolonged hyperglycaemia. There appears to be a similarity in the pathogenesis of DR and PD. Read More
Neurol Clin 2019 Feb;37(1):85-102
Department of Neurology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA; Department of Ophthalmology, Massachusetts Eye and Ear, 243 Charles Street, Boston, MA 02114, USA. Electronic address:
The physiologic changes that accompany pregnancy can have important implications for neuro-ophthalmic disease. This article discusses pregnancy-related considerations for meningioma, pituitary disorders, demyelinating disease, myasthenia gravis, thyroid eye disease, idiopathic intracranial hypertension, cerebral venous sinus thrombosis, stroke, migraine, and cranial neuropathies. The article also details the potential neuro-ophthalmic complications of preeclampsia and eclampsia and reviews the use of common diagnostic studies during pregnancy. Read More
Mol Brain 2018 11 21;11(1):69. Epub 2018 Nov 21.
School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, CF24 4HQ, UK.
Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma. Retinal ganglion cell neurites are surrounded by a specialised glycosaminoglycan extracellular matrix which inhibits dendritic plasticity. Since digestion of the extracellular matrix by chondroitinase ABC has been reported to have neuro-regenerative and neuro-plastic effects within the central nervous system, we explored its potential for dendritic recovery in a rat model of ocular hypertension. Read More
Klin Monbl Augenheilkd 2018 Nov 20;235(11):1212-1217. Epub 2018 Nov 20.
Klinik für Augenheilkunde, Universität Magdeburg, Magdeburg.
Despite many technical advances, psychophysical testing of perceptual performance continues to play an important role in ophthalmic diagnostics, including neuro-ophthalmology. The present article considers methodological and clinical aspects of examining visual acuity, contrast sensitivity, and colour vision. In contrast to acuity, contrast sensitivity is at present rarely tested, despite often being a more sensitive marker of disease. Read More
Radiol Case Rep 2019 Feb 13;14(2):226-229. Epub 2018 Nov 13.
Division of Neuroradiology, Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Room S-047, Stanford, CA 94305-5105, USA.
Malignant optic glioma presents a clinical and diagnostic challenge, as early imaging findings overlap with other more common causes of optic nerve enhancement and enlargement, potentially leading to delay in diagnosis. This rare diagnosis carries an extremely poor prognosis, with death usually occurring within 1 year. We present a case of malignant optic glioma that was initially diagnosed as optic neuritis and central retinal vein occlusion, and we emphasize the importance of serial imaging and definitive biopsy to promote early diagnosis and treatment of this entity. Read More
Am J Hum Genet 2018 Dec 15;103(6):976-983. Epub 2018 Nov 15.
Department of Ophthalmology, Haukeland University Hospital, N-5021 Bergen, Norway; Department of Medical Genetics, Haukeland University Hospital, N-5021 Bergen, Norway; Department of Clinical Medicine, University of Bergen, N-5021 Bergen, Norway.
We have investigated a distinct disorder with progressive corneal neovascularization, keloid formation, chronic skin ulcers, wasting of subcutaneous tissue, flexion contractures of the fingers, and acro-osteolysis. In six affected individuals from four families, we found one of two recurrent variants in discoidin domain receptor tyrosine kinase 2 (DDR2): c.1829T>C (p. Read More
JAMA Ophthalmol 2018 Oct 25. Epub 2018 Oct 25.
Department of Neuro-ophthalmology, Aravind Eye Care, Pondicherry, India.
J Neuroophthalmol 2018 Dec;38(4):538-550
Department of Ophthalmology (JCH, DLA), Program in Neuroscience, University of California San Francisco, San Francisco, California; and Center for Mind/Brain Sciences (DLA), The University of Trento, Trento, Italy.
The cerebral cortex is supplied by vascular microlobules, each comprised of a half dozen penetrating arterioles that surround a central draining venule. The surface arterioles that feed the penetrating arterioles are interconnected via an extensively anastomotic plexus. Embolic occlusion of a small surface arteriole rarely produces a local infarct, because collateral blood flow is available through the vascular reticulum. Read More
J Neuroophthalmol 2018 Nov 7. Epub 2018 Nov 7.
Department of Neuro Ophthalmology, Postgraduate Institute of Ophthalmology, Aravind Eye Hospital, Coimbatore, India.
J Neuroophthalmol 2018 Nov 7. Epub 2018 Nov 7.
Lysholm Department of Neuroradiology (OYW, ID), National Hospital for Neurology and Neurosurgery, London, United Kingdom; Department of Neuro-Ophthalmology (Y-HT, ML, FB), National Hospital for Neurology and Neurosurgery, London, United Kingdom; and Department of Brain Repair and Rehabilitation (ID), UCL Institute of Neurology, London, United Kingdom.
Curr Opin Neurol 2018 Nov 9. Epub 2018 Nov 9.
Save Sight Institute, The University of Sydney.
Purpose Of Review: Obstructive sleep apnea (OSA) is increasing in prevalence. The intermittent hypoxia of OSA has wide-ranging effects on a patient's general health outcomes. However, gold-standard investigations and treatment are expensive and a significant burden on patients. Read More
Clin Exp Ophthalmol 2018 Oct 30. Epub 2018 Oct 30.
LVF Ophthalmology Research Centre, Translational Research Institute, Woolloongabba, Queensland, Australia.
The retina is the tissue responsible for light detection, in which retinal neurons convert light energy into electrical signals to be transported towards the visual cortex. Damage of retinal neurons leads to neuronal cell death and retinal pathologies, compromising visual acuity and eventually leading to irreversible blindness. Models of retinal neurodegeneration include 2D systems like cell lines, disassociated cultures and co-cultures, and 3D models like organoids, organotypic retinal cultures and animal models. Read More
North Clin Istanb 2018 17;5(2):153-156. Epub 2018 Apr 17.
Department of Ophthalmology, Kartal Lütfü Kırdar Training and Research Hospital, Istanbul, Turkey.
A 27-year-old female presented to the Clinic of Ophthalmology with the complaints of photophobia, headache, and diplopia. An ophthalmological examination indicated that her best-corrected visual acuity was 20/20 in both eyes with decreased contrast sensitivity. Fundoscopic examination revealed bilateral papilledema. Read More
BMC Ophthalmol 2018 Oct 26;18(1):278. Epub 2018 Oct 26.
Ocular Oftalmologia, Vitória, Brazil.
Background: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. Read More
J Clin Neurosci 2018 Oct 23. Epub 2018 Oct 23.
Alfred Hospital, Department of Neurology, Melbourne, Australia. Electronic address:
A previously well man presented with several months' history of neurological symptoms including diplopia and balance difficulties. Examination revealed fluctuating neurological deficits, fatigable weakness and slowed saccades. Extensive testing revealed mildly elevated cerebrospinal fluid protein, strongly positive single fiber electromyography and a dorsal pontine lesion at the floor of the 4th ventricle. Read More