88 results match your criteria Neuro-Ophthalmic History


Glaucomatous optic disc changes despite normal baseline intraocular pressure in a child.

Am J Ophthalmol Case Rep 2019 Mar 14;13:104-109. Epub 2018 Dec 14.

Bascom Palmer Eye Institute, The University of Miami Miller School of Medicine, 900 NW 17th Street 450N, Miami, FL, 33136, USA.

Purpose: We describe a case of normal tension glaucoma in the setting of sickle cell disease in a 9-year-old patient with a five-year follow up.

Observations: A 9-year-old male patient with a history of sickle cell disease presented initially at the age of 4 years for evaluation of a brief episode of nonspecific eye pain that had spontaneously resolved prior to the clinic visit. Over the course of several years, the patient was noted to have progressive optic disc cupping bilaterally, retinal nerve fiber layer thinning bilaterally, and has developed a corresponding inferior arcuate defect on automated visual field testing in the right eye, all without elevated intraocular pressures (IOP). Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307040PMC

Value of medical history in ophthalmology: A study of diagnostic accuracy.

J Curr Ophthalmol 2018 Dec 27;30(4):359-364. Epub 2018 Sep 27.

Doheny Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Purpose: This study aimed to demonstrate the value of the chief compliant and patient history to accurately diagnose patient pathology without requiring ocular examination or imaging in an outpatient neuro-ophthalmology clinic.

Methods: We prospectively evaluated 115 consecutive patients at our institution from January to April 2009. The attending neuro-ophthalmologist committed to a single most likely diagnosis while solely being exposed to patient demographic information (age, gender, race) and chief complaint, but was otherwise blinded to ocular examination or imaging. Read More

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http://dx.doi.org/10.1016/j.joco.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277212PMC
December 2018

Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis.

BMC Ophthalmol 2018 Oct 26;18(1):278. Epub 2018 Oct 26.

Ocular Oftalmologia, Vitória, Brazil.

Background: Sudden visual loss and optic disc edema caused by optic neuritis (ON) is usually followed by significant visual recovery. However, little or no recovery occurs when the loss is caused by atypical ON, especially in patients with neuromyelitis optica (NMO). Optic disc drusen (ODD) is a cause of pseudo optic disc edema and may be a predisposing factor for non-arteritic anterior ischemic optic neuropathy (NAION), thereby mimicking atypical ON. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0949-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203970PMC
October 2018
7 Reads

Bilateral oculomotor ocular neuromyotonia: a case report.

BMC Neurol 2018 Sep 3;18(1):137. Epub 2018 Sep 3.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.

Background: Ocular neuromyotonia (ONM) is characterized by episodic diplopia, which is usually triggered by prolonged eccentric gaze of the affected extraocular muscles. The spell is characterized by involuntary, occasionally painful, sustained contraction of one or more extraocular muscles innervated by the oculomotor, trochlear, or abducens nerve. ONM usually occurs as a late consequence of radiotherapy around the parasellar area, although idiopathic cases have been reported. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1142-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120096PMC
September 2018
9 Reads

The Outcomes of Pituitary Apoplexy with Conservative Treatment: Experiences at a Single Institution.

World Neurosurg 2018 Jul 27;115:e703-e710. Epub 2018 Apr 27.

Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objective: Pituitary apoplexy is an unpredictable complication caused by hemorrhage or infarction in a pituitary adenoma. We retrospectively analyzed the radiologic and clinical outcomes of patients with conservatively managed pituitary apoplexy.

Methods: A total of 32 patients who had undergone conservative treatment with high-dose corticosteroid replacement were enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.139DOI Listing
July 2018
2 Reads

Vertical diplopia and oscillopsia due to midbrain keyhole aqueduct syndrome associated with severe cough.

Am J Ophthalmol Case Rep 2018 Jun 15;10:128-131. Epub 2018 Feb 15.

Department of Ophthalmology, Stanford School of Medicine, 2452 Watson Court, Palo Alto, CA 94303-5353, USA.

Purpose: Midline structural defects in the neural axis can give rise to neuro-ophthalmic symptoms. We report a rare case of keyhole aqueduct syndrome presenting after two years of severe cough due to gastroesophageal reflux disease.

Observations: A 58-year-old woman with a 2-year history of daily, severe cough presented to the neuro-ophthalmology clinic with progressive diplopia and oscillopsia. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910451PMC
June 2018
4 Reads

An atypical case of neurosarcoidosis presenting with neovascular glaucoma.

J Ophthalmic Inflamm Infect 2018 Apr 18;8(1). Epub 2018 Apr 18.

Department of Ophthalmology, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium.

Background: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative.

Findings: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Read More

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http://dx.doi.org/10.1186/s12348-018-0149-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906415PMC
April 2018
2 Reads

Gene Therapy for Leber Hereditary Optic Neuropathy: Low- and Medium-Dose Visual Results.

Ophthalmology 2017 11 21;124(11):1621-1634. Epub 2017 Jun 21.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Purpose: To determine the effects of AAV2(Y444,500,730F)-P1ND4v2 in patients with Leber hereditary optic neuropathy (LHON).

Design: Prospective open-label, unilateral single-dose, intravitreal injection of AAV2(Y444,500,730F)-P1ND4v2 per participant.

Participants: Fourteen patients with visual loss and mutated G11778A mitochondrial DNA. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831379PMC
November 2017
13 Reads

Syringomyelia presenting with unilateral optic neuropathy: a case report.

Int Med Case Rep J 2017 14;10:87-91. Epub 2017 Mar 14.

Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Purpose: In this case report, we present two cases of syringomyelia with optic neuropathy.

Findings: In Case 1, a 36-year-old Malay lady presented to our clinic with acute onset of blurring of vision in her left eye that she experienced since past 1 month. She was diagnosed with syringomyelia 12 years ago and was on conservative management. Read More

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http://dx.doi.org/10.2147/IMCRJ.S129239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359140PMC
March 2017
1 Read

Recurrent Squamous Cell Carcinoma of the Eyelid Presenting as Trigeminal Neuralgia.

Cureus 2016 Dec 16;8(12):e932. Epub 2016 Dec 16.

Ophthalmology, Orlando VA Medical Center ; Ophthalmology, University of Central Florida College of Medicine.

This paper describes two patients with squamous cell carcinoma (SCC) of the periocular and periorbital skin who presented with trigeminal neuralgia. Both patients had previous cutaneous SCC of the scalp treated successfully with surgical resection but later presented with neuro-ophthalmic findings suggesting perineural invasion (PNI) of SCC. PNI of SCC in the periocular skin or orbit can lead to devastating effects if malignant cells seed into the orbit and adjacent cranial nerves as our two patients developed an orbital apex syndrome. Read More

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http://dx.doi.org/10.7759/cureus.932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235655PMC
December 2016
1 Read

Abnormal eye movement behavior during reading in Parkinson's disease.

Parkinsonism Relat Disord 2016 11 12;32:130-132. Epub 2016 Aug 12.

Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Introduction: Reading difficulties are common in Parkinson's disease (PD) but not well studied. We report a case of reading difficulties in a 40-year-old man with 6-year history of PD on dopamine replacement therapy.

Methods: We performed detailed neuro-ophthalmic examination and assessment of reading with and without infrared oculography. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2016.08.008DOI Listing
November 2016
2 Reads

20/40 or Better Visual Acuity After Optic Neuritis: Not as Good as We Once Thought?

J Neuroophthalmol 2016 12;36(4):369-376

Departments of Neurology (SBS, RCN, KN, SLG, LJB), Population Health (LJB) and Ophthalmology (SLG, LJB), New York University School of Medicine, New York, New York; Department of Neurology (KMG, JAW), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Department of Neurology (PAC), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Department of Neurology (EMF), University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Although patients with acute optic neuritis (ON) recover high-contrast visual acuity (HCVA) to 20/40 or better in 95% of affected eyes, patients with a history of ON continue to note subjective abnormalities of vision. Furthermore, substantial and permanent thinning of the retinal nerve fiber layer (RNFL) and the ganglion cell layer (GCL) is now known to occur early in the course of ON. We measured vision-specific quality of life (QOL) in patients with a history of acute ON and recovery of VA to 20/40 or better in their affected eyes to determine how these QOL scores relate to RNFL and GCL thickness and low-contrast letter acuity (LCLA) across the spectrum of visual recovery. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000421DOI Listing
December 2016
6 Reads

Plasma exchange response in 34 patients with severe optic neuritis.

J Neurol 2016 May 10;263(5):883-887. Epub 2016 Mar 10.

Service de Neurologie, Fondation Ophtalmologique Adolphe de Rothschild, 25 Rue Manin, 75019, Paris, France.

Optic neuritis could lead to severe visual impairment despite corticosteroids. Our aim was to evaluate the rate of visual improvement in patients treated with plasma exchange (PLEX) for severe steroid unresponsive optic neuritis and to identify predictive factors of outcome. Thirty-four patients (41 optic nerves damaged) with remaining visual acuity of 0. Read More

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http://dx.doi.org/10.1007/s00415-016-8073-8DOI Listing
May 2016
13 Reads
1 Citation
3.380 Impact Factor

Neuro-Ophthalmology of Space Flight.

J Neuroophthalmol 2016 Mar;36(1):85-91

Department of Ophthalmology (AGL, CRB), Houston Methodist Hospital, Houston, Texas; Department of Ophthalmology (AGL), Baylor College of Medicine, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medical College, New York, New York; Department of Ophthalmology (AGL), The University of Texas Medical Branch, Galveston, Texas; Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa; Section of Ophthalmology (AGL), The University of Texas MD Anderson Cancer Center, Houston, Texas; Space Medicine Division (WJT, SFH), National Aeronautics and Space Administration, Washington, DC; US Army (THM), Cooper Landing, Alaska; Coastal Eye Associates (CRG), Webster, Texas; and Universities Space Research Association (CO), National Aeronautics and Space Administration, Washington, DC.

Background: To describe the history, clinical findings, and possible pathogenic etiologies of the constellation of neuro-ophthalmic findings discovered in astronauts after long-duration space flight and to discuss the terrestrial implications of such findings.

Evidence Acquisition: Retrospective review of published observational, longitudinal examination of neuro-ophthalmic findings in astronauts after long-duration space flight; analysis of postflight questionnaires regarding in-flight vision changes in approximately 300 additional astronauts; and hypothesis generating for developing possible future countermeasures and potential implications for neuro-ophthalmic disorders on Earth. Astronauts with neuro-ophthalmic findings, which were not present at the start of a space flight mission and only seen on return from long-duration space missions to the International Space Station, will be discussed. Read More

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http://pdfs.journals.lww.com/jneuro-ophthalmology/2016/03000
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/WNO.0000000000000334DOI Listing
March 2016
22 Reads

Ocular motor assessment in concussion: Current status and future directions.

J Neurol Sci 2016 Feb 9;361:79-86. Epub 2015 Dec 9.

New York University School of Medicine, Department of Neurology, United States.

Mild head injury such as concussions and subconcussive repetitive impact may lead to subtle changes in brain function and it is imperative to find sensitive and reliable tests to detect such changes. Tests involving the visual system, in particular eye movements, can incorporate higher cortical functioning and involve diffuse pathways in the brain, including many areas susceptible to head impact. With concussions, the clinical neuro-ophthalmic exam is important for detecting abnormalities in vergence, saccades, pursuit, and visual fixation. Read More

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http://dx.doi.org/10.1016/j.jns.2015.12.010DOI Listing
February 2016
9 Reads

A rare manifestation of neuro-ophthalmic sarcoidosis: A case report.

Taiwan J Ophthalmol 2016 Jan-Mar;6(1):45-51. Epub 2015 Apr 3.

Department of Ophthalmology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.

Purpose: Anterior uveitis is the most common ocular manifestation of sarcoidosis. Ocular involvement affects approximately 30-60% of patients with systemic sarcoidosis; however, optic disc edema is a rare event. We report a patient who presented with a rare case of sarcoidosis with neuro-ophthalmic manifestations. Read More

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http://dx.doi.org/10.1016/j.tjo.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602126PMC
April 2015
5 Reads

[Neuro-ophthalmic adverse effects of metronidazole treatment in children: Two case studies].

Arch Pediatr 2016 Feb 14;23(2):167-70. Epub 2015 Dec 14.

Service d'ophtalmologie B, institut Hédi-Rais, boulevard 9-avril, 1006 Tunis, Tunisie.

Purpose: To report the onset of neuro-ophthalmological adverse effects in two children treated with metronidazole for amoebic dysentery.

Observations: A 6-year-old child and his 8-year-old sister presented with sudden bilateral vision loss and diplopia associated with intense headache and vomiting. The medical history revealed amoebic dysentery 3 weeks before treated orally with metronidazole for 2 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0929693X150042
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http://dx.doi.org/10.1016/j.arcped.2015.11.003DOI Listing
February 2016
5 Reads

Clinical and allelic heterogeneity in a pediatric cohort of 11 patients carrying MFN2 mutation.

Brain Dev 2016 May 10;38(5):498-506. Epub 2015 Dec 10.

Department of Neuropaediatrics, Timone Hospital, Marseille Teaching Hospital, France.

Introduction: The Mitofusin 2 gene (MFN2), which encodes a mitochondrial membrane protein, is known to be the first cause of autosomal dominant Charcot-Marie-Tooth disease type 2 (CMT2) with early onset. This gene is involved in typical CMT2A and in more atypical phenotypes as optic atrophy or spastic paraplegia. CMT2 refers to inherited axonal polyneuropathy, which associates progressive peripheral motor and sensory neuropathy, a family history consistent mainly with autosomal dominant inheritance, and normal nerve conduction velocities. Read More

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http://dx.doi.org/10.1016/j.braindev.2015.11.006DOI Listing
May 2016
17 Reads

Wernicke Encephalopathy.

Am Orthopt J 2015 ;65:104-8

From the Neuro-Ophthalmology of Texas Medical Clinic, Houston, Texas.

Introduction And Purpose: This paper reviews the complaints and associated symptoms/consequences of lacking essential nutrients and vitamins in our central and peripheral nervous systems. This has become important as there has been a rise in malnutrition following the increasing incidence of bariatric surgery for obesity.

Methods: A case report example involving review of the clinical presentation and treatment. Read More

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http://dx.doi.org/10.3368/aoj.65.1.104DOI Listing
April 2016
5 Reads

Neuro-Ophthalmic Syndromes and Processing Speed in Multiple Sclerosis.

J Neuroophthalmol 2016 Mar;36(1):23-8

Neuropsychophysiology Lab-CIPsi (SLC, OFG), University of Minho, Braga, Portugal; Neuropsychology and Neuroscience Research (SLC, NDC, JDL), Kessler Foundation, West Orange, New Jersey; Department of Physical Medicine and Rehabilitation (SLC, OFG, NDC), Rutgers New Jersey Medical School, Newark, New Jersey; Department of Counseling and Applied Educational Psychology(OFG), Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts; Spaulding Neuromodulation Center (OFG), Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts; Department of Neurology (OFG), Rutgers New Jersey Medical School, Newark, New Jersey; Faculty of Psychology and Educational Sciences (JA), University of Coimbra, Coimbra, Portugal; Proaction Laboratory (JA), Faculty of Phycology and Educational Sciences, University of Coimbra, Portugal.

The impact of prior neuro-ophthalmic syndromes on the performance on vision-based neuropsychological tasks in patients with multiple sclerosis (MS) is unknown. Two groups of MS participants, one with (Msos+) and the other without (Msos-), a history of neuro-ophthalmic syndromes, underwent neuropsychological assessment and were compared with healthy age- and education-matched controls (HC). Participants with Msos+ performed significantly worse on the symbol digit modalities test than the Msos- (P < 0. Read More

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http://pdfs.journals.lww.com/jneuro-ophthalmology/9000/00000
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/WNO.0000000000000272DOI Listing
March 2016
3 Reads

Quality of life in idiopathic intracranial hypertension at diagnosis: IIH Treatment Trial results.

Neurology 2015 Jun 20;84(24):2449-56. Epub 2015 May 20.

From the Moran Eye Center (K.B.D.), University of Utah, Salt Lake City; Departments of Ophthalmology, Neurology, and Epidemiology (B.B.B.), Emory University, Atlanta, GA; Departments of Biostatistics and Computational Biology and Neurology (M.P.M.), and Center for Human Experimental Therapeutics, University of Rochester Medical Center, NY; Department of Neurology (K.M.G.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (L.J.B.), New York University; and Department of Ophthalmology and Visual Sciences (M.W.), University of Iowa Carver College of Medicine, Iowa City.

Objective: The study purpose was to examine vision-specific and overall health-related quality of life (QOL) at baseline in Idiopathic Intracranial Hypertension Treatment Trial patients who were newly diagnosed and had mild visual loss. We also sought to determine the associations between vision-specific QOL scores and visual symptoms, visual function, pain, headache-related disability, and obesity.

Methods: We assessed QOL using the 36-Item Short Form Health Survey, National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25), and 10-Item NEI-VFQ-25 Neuro-Ophthalmic Supplement. Read More

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http://www.neurology.org/content/84/24/2449.full.pdf
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http://www.thejournalofheadacheandpain.com/content/pdf/s1019
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000168
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http://dx.doi.org/10.1212/WNL.0000000000001687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478032PMC
June 2015
8 Reads

Convergence insufficiency associated with migraine: a case series.

Am Orthopt J 2014 ;64:112-6

Family Eye Group, Lancaster, Pennsylvania.

Background And Purpose: The appearance of convergence insufficiency in migraineurs suggests a possible link between migraine and convergence insufficiency.

Patients And Method: Relevant patients reporting to our neuro-ophthalmology clinic complained of symptoms consistent with convergence insufficiency and had a history of migraine. Patients underwent thorough neuro-ophthalmic evaluations including history, physical exam, and cranial imaging. Read More

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http://aoj.uwpress.org/content/64/1/112.full.pdf
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http://aoj.uwpress.org/cgi/doi/10.3368/aoj.64.1.112
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http://dx.doi.org/10.3368/aoj.64.1.112DOI Listing
March 2015
4 Reads
2 Citations

The King-Devick (K-D) test of rapid eye movements: a bedside correlate of disability and quality of life in MS.

J Neurol Sci 2014 Aug 2;343(1-2):105-9. Epub 2014 Jun 2.

Department of Neurology, New York University School of Medicine, New York, NY, United States; Department of Population Health, New York University School of Medicine, New York, NY, United States. Electronic address:

Objective: We investigated the King-Devick (K-D) test of rapid number naming as a visual performance measure in a cohort of patients with multiple sclerosis (MS).

Methods: In this cross-sectional study, 81 patients with MS and 20 disease-free controls from an ongoing study of visual outcomes underwent K-D testing. A test of rapid number naming, K-D requires saccadic eye movements as well as intact vision, attention and concentration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X140035
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http://dx.doi.org/10.1016/j.jns.2014.05.047DOI Listing
August 2014
15 Reads

Trial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : preparation for gene therapy clinical trial.

JAMA Ophthalmol 2014 Apr;132(4):428-36

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

IMPORTANCE Establishing the natural history of G11778A Leber hereditary optic neuropathy (LHON) is important to determine the optimal end points to assess the safety and efficacy of a planned gene therapy trial. OBJECTIVE To use the results of the present natural history study of patients with G11778A LHON to plan a gene therapy clinical trial that will use allotopic expression by delivering a normal nuclear-encoded ND4 gene into the nuclei of retinal ganglion cells via an adeno-associated virus vector injected into the vitreous. DESIGN, SETTING, AND PARTICIPANTS A prospective observational study initiated in 2008 was conducted in primary and referral institutional practice settings. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2013.7971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266137PMC
April 2014
11 Reads

Accommodation Paralysis after Pheniramine Maleate Injection: A Case Report.

Neuroophthalmology 2013 19;37(6):257-259. Epub 2013 Nov 19.

Department of Ophthalmology, Faculty of Medicine, Ankara University Dikimevi, Ankara Turkey.

We present a case in which Gilbert syndrome was diagnosed following a neuro-ophthalmic complaint. Adverse effects of drugs as well as various systemic, neurological, and local ocular pathologies can cause accommodative insufficiency and loss of accommodation. A 29-year-old man was admitted to an ophthalmology department with blurred vision and diagnosed as suffering from acute accommodation paralysis. Read More

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http://dx.doi.org/10.3109/01658107.2013.830227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291063PMC
November 2013
1 Read

Visual quality of life in veterans with blast-induced traumatic brain injury.

JAMA Ophthalmol 2013 Dec;131(12):1602-9

Ophthalmology Service, VA Palo Alto Health Care System, Palo Alto, California4Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California.

Importance: Traumatic brain injury (TBI) is an important cause of morbidity worldwide, with increasing awareness of the role of blast exposure in military and civilian casualties. Visual problems have been reported in TBI and may affect functioning and quality of life.

Objective: To evaluate the 25-item National Eye Institute Visual Functioning Questionnaire and Neuro-Ophthalmic Supplement for utility in assessing the effect of blast exposure on perceived visual functioning among veterans with TBI. Read More

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http://mldc.whs.mil/public/docs/library/131021_BVA_Visual_Qu
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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2013.5028DOI Listing
December 2013
2 Reads

[Clinical practice guideline for the diagnosis and treatment of pituitary apoplexy].

Endocrinol Nutr 2013 Dec 14;60(10):582.e1-582.e12. Epub 2013 Sep 14.

Servicio de Endocrinología y Nutrición, Hospital Virgen de la Salud, Complejo Hospitalario de Toledo, Toledo, España. Electronic address:

Unlabelled: Classic pituitary apoplexy (PA) is an acute, life-threatening clinical syndrome caused by acute hemorrhage and/or infarction of the pituitary gland. PA is considered a neuroendocrinological emergency. However, there is no consensus about the best options for PA diagnosis and management. Read More

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http://dx.doi.org/10.1016/j.endonu.2013.04.013DOI Listing
December 2013
18 Reads

[Ocular and neuro-ophthalmic manifestations of sarcoidosis: retrospective study of 30 cases].

J Fr Ophtalmol 2013 Jun 29;36(6):473-80. Epub 2013 Mar 29.

Service d'ophtalmologie, CHRU de Tours, boulevard Tonnellé, 37000 Tours, France.

Introduction: The purpose of this study was to describe the diagnostic strategy and therapeutic approach when sarcoidosis of the visual pathways is suspected, by way of a descriptive study of sarcoidosis patients in the ophthalmology services in Tours, Rennes and Angers.

Patients And Methods: A multicenter, retrospective chart review was performed for 30 patients diagnosed with sarcoidosis and followed at the university hospitals of Tours, Rennes and Angers between January 1997 and August 2011. The diagnosis of sarcoidosis was based on a combination of clinical and ancillary tests, including pathologic confirmation and/or hyperlymphocytosis with a CD4/CD8 ratio greater than 5 on bronchoalveolar lavage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01815512130005
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http://dx.doi.org/10.1016/j.jfo.2012.06.029DOI Listing
June 2013
3 Reads

Intravitreal bevacizumab for the treatment of nonarteritic anterior ischemic optic neuropathy: a prospective trial.

Eye (Lond) 2013 Apr 1;27(4):538-44. Epub 2013 Feb 1.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Purpose: There is currently no accepted treatment for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION). One new therapeutic approach involves decreasing optic nerve edema with intravitreal bevacizumab in order to resolve a proposed compartment syndrome.

Methods: In this non-randomized controlled clinical trial, 1. Read More

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http://www.nature.com/articles/eye2012296
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http://dx.doi.org/10.1038/eye.2012.296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626001PMC
April 2013
2 Reads

Chiari I malformation presenting as downbeat nystagmus: clinical presentation, diagnosis, and management.

Optometry 2012 Feb 15;83(2):80-6. Epub 2012 Feb 15.

Pacific University College of Optometry, 2043 College Way, Forest Grove, OR 97116, USA.

Introduction: Chiari I malformation is a congenital, neurological condition that is characterized by defects of the skull base resulting in herniation of the cerebellum through the foramen magnum into the cervical spinal canal. Because the condition can result in visual symptoms, patients will often search for answers from their eye care providers;

Case Report: A 28-year-old Hispanic diabetic male with a 10-year history of nystagmus was referred to the neuro-ophthalmic disease clinic following the initiation of oscillopsia 1 year previous. Downbeat nystagmus, which worsened in right and down gaze, was evident. Read More

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February 2012
10 Reads

Miller Fisher syndrome mimicking ocular myasthenia gravis.

Optom Vis Sci 2012 Dec;89(12):e118-23

Optometry Clinic Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA.

PURPOSE.: Miller Fisher syndrome (MFS) is a rare immune-mediated neuropathy that commonly presents with diplopia after the acute onset of complete bilateral external ophthalmoplegia. Ophthalmoplegia is often accompanied by other neurological deficits such as ataxia and areflexia that characterize MFS. Read More

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http://dx.doi.org/10.1097/OPX.0b013e31827717c1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516407PMC
December 2012
30 Reads

Progressive visual and hearing loss secondary to neurosyphilis.

Optom Vis Sci 2012 Nov;89(11):e65-71

Neuro-Ophthalmic Disease Service, Pennsylvania College of Optometry at Salus University, 1200 West Godfrey Ave Philadelphia, Pennsylvania 19141, USA.

Purpose: There is a rising incidence of syphilis in economically advanced countries. Early diagnosis can spare the patient devastating vision and hearing loss, as well as other significant morbidity. Ocular presentations of neurosyphilis are varied and numerous, requiring syphilis to be considered in many clinical situations, even if a negative medical history is reported. Read More

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http://pdfs.journals.lww.com/optvissci/2012/11000/Progressiv
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http://dx.doi.org/10.1097/OPX.0b013e31826ae123DOI Listing
November 2012
3 Reads

Dominant optic atrophy.

Orphanet J Rare Dis 2012 Jul 9;7:46. Epub 2012 Jul 9.

Institut des Neurosciences de Montpellier, U1051 de l'INSERM, Université de Montpellier I et II, BP 74103, F-34091 Montpellier cedex 05, France.

Unlabelled: DEFINITION OF THE DISEASE: Dominant Optic Atrophy (DOA) is a neuro-ophthalmic condition characterized by a bilateral degeneration of the optic nerves, causing insidious visual loss, typically starting during the first decade of life. The disease affects primary the retinal ganglion cells (RGC) and their axons forming the optic nerve, which transfer the visual information from the photoreceptors to the lateral geniculus in the brain.

Epidemiology: The prevalence of the disease varies from 1/10000 in Denmark due to a founder effect, to 1/30000 in the rest of the world. Read More

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http://dx.doi.org/10.1186/1750-1172-7-46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526509PMC
July 2012
13 Reads

Neuroimaging in patients referred to a neuro-ophthalmology service: the rates of appropriateness and concordance in interpretation.

Ophthalmology 2012 Aug 6;119(8):1701-4. Epub 2012 Apr 6.

Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, Missouri, USA.

Objective: Neuroimaging studies frequently are ordered to investigate neuro-ophthalmic symptoms. When misused, these studies are expensive and time consuming. This study describes the type and frequency of neuroimaging errors in patients referred to an academic neuro-ophthalmology service and measures how frequently these neuroimaging studies were reinterpreted. Read More

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http://dx.doi.org/10.1016/j.ophtha.2012.01.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394876PMC
August 2012
3 Reads

Ganglion cell loss in relation to visual disability in multiple sclerosis.

Ophthalmology 2012 Jun 23;119(6):1250-7. Epub 2012 Feb 23.

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Purpose: We used high-resolution spectral-domain optical coherence tomography (SD-OCT) with retinal segmentation to determine how ganglion cell loss relates to history of acute optic neuritis (ON), retinal nerve fiber layer (RNFL) thinning, visual function, and vision-related quality of life (QOL) in multiple sclerosis (MS).

Design: Cross-sectional study.

Participants: A convenience sample of patients with MS (n = 122; 239 eyes) and disease-free controls (n = 31; 61 eyes). Read More

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http://dx.doi.org/10.1016/j.ophtha.2011.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631566PMC
June 2012
12 Reads

One eye or two: a comparison of binocular and monocular low-contrast acuity testing in multiple sclerosis.

Am J Ophthalmol 2011 Jul 12;152(1):133-40. Epub 2011 May 12.

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA.

Purpose: To determine the magnitudes of binocular summation for low- and high-contrast letter acuity in a multiple sclerosis (MS) cohort, and to characterize the roles that MS disease, age, interocular difference in acuity, and a history of optic neuritis have on binocular summation. The relation between binocular summation and monocular acuities and vision-specific quality of life (QoL) was also examined.

Design: Cross-sectional observational study. Read More

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http://dx.doi.org/10.1016/j.ajo.2011.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637955PMC
July 2011
2 Reads

Recurrent nasal polyp and pansinus mucopyocele associated with bilateral blindness: a case report.

Ghana Med J 2010 Dec;44(4):165-8

Department of Otorhinolaryngology, University College Hospital, Queen Elizabeth Road, PMB 5116, Ibadan, Oyo State, Nigeria.

A 39 year old female with 24-month history of recurrent mucoid rhinorhea associated with progressive bilateral nasal blockage, headache, anosmia and bilateral impaired vision is reported. There was a past history of sinus surgery. The neuro-ophthalmic examination revealed left non-axial proptosis and visual acuity of nil light perception in both eyes at 3 meters. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052832PMC
December 2010
6 Reads

Isolated sixth cranial nerve palsy as the presenting symptom of a rapidly expanding ACTH positive pituitary adenoma: a case report.

BMC Ophthalmol 2011 Jan 27;11. Epub 2011 Jan 27.

Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA.

Background: Pituitary adenoma may present with neuro-ophthalmic manifestations and, typically, rapid tumor expansion is the result of apoplexy. Herein, we present the first case of an isolated sixth cranial nerve palsy as initial feature of a rapidly expanding ACTH positive silent tumor without apoplexy.

Case Presentation: A 44 year old female with a history of sarcoidosis presented with an isolated sixth cranial nerve palsy as the initial clinical feature of a rapidly expanding ACTH positive silent pituitary adenoma. Read More

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http://dx.doi.org/10.1186/1471-2415-11-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041999PMC
January 2011
1 Read

Orbital involvement in Bing-Neel syndrome.

J Neuroophthalmol 2010 Sep;30(3):255-9

Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

Bing-Neel syndrome (BNS) is defined as intracranial involvement of Waldenström macroglobulinemia (WM). Few cases of orbital involvement have been reported. A 51-year-old man with a history of WM developed bilateral orbitopathy and optic neuropathy. Read More

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http://pdfs.journals.lww.com/jneuro-ophthalmology/2010/09000
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http://dx.doi.org/10.1097/WNO.0b013e3181dee96cDOI Listing
September 2010
3 Reads

Friederich Nietzsche and the seduction of Occam's razor.

J Clin Neurosci 2010 Aug 12;17(8):966-9. Epub 2010 Jun 12.

Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

Friedrich Nietzsche developed dementia at the age of 44 years. It is generally assumed that the cause of his dementia was neurosyphilis or general pareisis of the insane (GPI). Others have proposed frontal-based meningioma as the underlying cause. Read More

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http://dx.doi.org/10.1016/j.jocn.2010.04.004DOI Listing
August 2010
3 Reads

Ocular features in neurosarcoidosis.

Ocul Immunol Inflamm 2009 May-Jun;17(3):170-8

Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, London, UK.

Background/aims: To determine the type of ocular involvement in patients with neurosarcoidosis, and evaluate whether the type of eye involvement may help in the diagnosis of neurosarcoidosis.

Methods: Retrospective, case history study. We reviewed the medical records of 46 patients who attended the sarcoidosis clinics at the Royal Brompton and Moorfields Eye Hospital over a 4-year period with a diagnosis of definite and probable neurosarcoidosis supported by laboratory investigations and exclusion of other causes for the neurological symptoms. Read More

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http://dx.doi.org/10.1080/09273940802687812DOI Listing
September 2009
5 Reads

A possible early description of nystagmus and photophobia in albinism.

Vesalius 2008 Dec;14(2):49-52

Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel.

It is recognized today that albinism is accompanied by a cohort of ophthalmic and neuro-ophthalmic problems. These may not always be as obvious to the casual observer as the lack of pigment in the eyebrows, hair, or skin, and thus early descriptions of this rare genetic condition may have initially focused on the unusual colour of the hair, skin, or eyebrows and not the eye-related problems. While it is not easy to find an accurate ancient description of albinism, we here propose that a Talmudic account from over 1500 years ago may possibly be describing nystagmus and photophobia in albinism in a population which resided along the River Tigris. Read More

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December 2008
2 Reads

[Idiopathic hypertrophic pachymeningitis: a case report].

Rev Neurol 2009 Mar 16-31;48(6):300-3

Departamento de Enfermedades Infecciosas del Sistema Nervioso y Neuropediatría, Instituto Nacional de Ciencias Neurológicas Oscar Trelles Montes, Lima, Peru.

Introduction: Hypertrophic pachymeningitis is a clinical condition that is caused by a diffuse or localised thickening of the dura mater. It predominantly affects males and manifests as chronic headache, with or without association to neurological manifestations, such as paralysis of the cranial nerves, cerebellar ataxia and neuro-ophthalmic complications.

Case Report: A 61-year-old male, with no relevant past history, who, one month before admission, had begun to suffer from right frontotemporal headache that irradiated to the ipsilateral orbital region and was more pronounced at night. Read More

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May 2009
3 Reads

Vision related quality of life in multiple sclerosis: correlation with new measures of low and high contrast letter acuity.

J Neurol Neurosurg Psychiatry 2009 Jul 23;80(7):767-72. Epub 2009 Feb 23.

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Objective: To examine the relation between low contrast letter acuity, a new visual function test for multiple sclerosis (MS) trials, and vision targeted health related quality of life (HRQOL).

Methods: Patients in this cross sectional study were part of an ongoing investigation of visual function in MS. Patients were tested binocularly using low contrast letter acuity and Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity (VA) charts. Read More

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http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.2008.165449
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http://dx.doi.org/10.1136/jnnp.2008.165449DOI Listing
July 2009
4 Reads

Traumatic brain injury associated with combat ocular trauma.

J Head Trauma Rehabil 2009 Jan-Feb;24(1):41-50

Ophthalmology Service, Walter Reed Army Medical Center, 6900 Georgia Ave, Washington, DC 20307, USA.

Purpose: To determine the impact of traumatic brain injury (TBI) on visual outcomes in combat ocular trauma (COT) and determine the association between TBI severity and types of ocular injuries.

Participants: One hundred fifty-two US casualties sustained 207 globe/oculoplastic combat injuries.

Methods: Retrospective, hospital-based cross-sectional study of US service members injured during Operations Iraqi Freedom and Enduring Freedom were treated by the Ophthalmology Service at Walter Reed Army Medical Center and screened for TBI by the Defense and Veterans Brain Injury Center from August 2004 to October 2006. Read More

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http://dx.doi.org/10.1097/HTR.0b013e3181956ffdDOI Listing
June 2009
5 Reads

Combat ocular trauma visual outcomes during operations iraqi and enduring freedom.

Ophthalmology 2008 Dec;115(12):2235-45

Walter Reed Army Medical Center, Washington, District of Columbia 20307, USA.

Objective: To report the visual and anatomic outcomes as well as to predict the visual prognosis of combat ocular trauma (COT) during Operations Iraqi and Enduring Freedom.

Design: Retrospective, noncomparative, interventional, consecutive case series.

Participants: Five hundred twenty-three consecutive globe or adnexal combat injuries, or both, sustained by 387 United States soldiers treated at Walter Reed Army Medical Center between March 2003 and October 2006. Read More

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http://dx.doi.org/10.1016/j.ophtha.2008.08.033DOI Listing
December 2008
7 Reads

Optic neuritis and multiple sclerosis.

Authors:
Gordon T Plant

Curr Opin Neurol 2008 Feb;21(1):16-21

The National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital and St Thomas' Hospital, London, UK.

Purpose Of Review: To discuss recent neuro-ophthalmic advances relevant to the management of optic neuritis and multiple sclerosis.

Recent Findings: Major advances have occurred in the fields of autoimmunity in optic neuritis, and in imaging the retinal nerve fibre layer in both optic neuritis and multiple sclerosis.

Summary: A proportion of cases of optic neuritis occur in patients who do not develop multiple sclerosis; the optic neuritis may be monophasic illness or recurrent. Read More

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https://insights.ovid.com/crossref?an=00019052-200802000-000
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http://dx.doi.org/10.1097/WCO.0b013e3282f419caDOI Listing
February 2008
4 Reads

Presumed levothyroxine-induced pseudotumor cerebri in a pediatric patient being treated for congenital hypothyroidism.

Clin Ophthalmol 2007 Dec;1(4):545-9

Illinois College of Optometry, Chicago, IL, USA.

Papilledema is considered a neuro-ophthalmic emergency because of its capacity to induce irreversible end-organ damage and the often grave nature of its precipitating factor. Even more concern is warranted when papilledema presents in a pediatric setting. After excluded the contributions of intracranial masses, congenital malformations, ischemic insults and acute infections, the investigation must focus on determining the contributions of other uncharacteristic causes of pediatric pseudotumor cerebri. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704528PMC
December 2007
2 Reads

Optic neuritis and the neuro-ophthalmology of multiple sclerosis.

Int Rev Neurobiol 2007 ;79:633-63

Department of Neurology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA.

Multiple sclerosis (MS) is the most common cause of neurological disability in young adults. Since approximately 40% of the brain is devoted to vision, demyelination commonly affects visual function, resulting in a myriad of neuro-ophthalmic symptoms. In this chapter, we examine the seminal afferent and efferent neuro-ophthalmological manifestations of MS, highlighting those history and examination findings critical for the diagnosis and treatment of various visual and ocular motor disorders. Read More

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http://dx.doi.org/10.1016/S0074-7742(07)79028-1DOI Listing
August 2007
4 Reads
4 Citations
1.920 Impact Factor

Bilateral sequential optic neuropathy as the initial manifestation of Sjögren syndrome.

Klin Monbl Augenheilkd 2007 Apr;224(4):337-9

Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.

Background: Neuro-ophthalmic findings are uncommon in the setting of Sjögren syndrome. We report the case of a patient with bilateral, sequential optic neuropathy as the initial manifestation of Sjögren syndrome.

History And Signs: A 38-year-old male presented with sudden painless visual loss in his left eye in May 2005. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-962950
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http://dx.doi.org/10.1055/s-2007-962950DOI Listing
April 2007
2 Reads