227 results match your criteria Neuro-Ophthalmic Examination


Neuro-Ophthalmology for Internists.

Med Clin North Am 2021 May;105(3):511-529

Department of Ophthalmology, University of Pennsylvania, 51 N 39th St, Philadelphia, PA 19104, USA.

Neuro-ophthalmology is the study of the neurologic underpinnings of vision and includes a fascinating variety of disorders that span the broad spectrum of ophthalmic and neurologic disease. This subspecialty relies heavily on accurate neuroanatomic localization and examination. This article discusses neuro-ophthalmic complaints that frequently present to the internist, including acute vision loss, double vision, and unequal pupils. Read More

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Internuclear ophthalmoplegia as a presenting feature in a COVID-19-positive patient.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Child Sight Institute, Jasti V Ramanamma Children's Eye Care Centre, LV Prasad Eye Institute, Hyderabad, India

A 58-year-old man presented with vertical diplopia for 10 days which was sudden in onset. Extraocular movement examination revealed findings suggestive of internuclear ophthalmoplegia. Investigations were suggestive of diabetes mellitus, and reverse transcription-PCR for SARS-CoV-2 was positive. Read More

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Binasal visual field defects caused by temporal posterior subcapsular cataracts.

Taiwan J Ophthalmol 2021 Jan-Mar;11(1):101-103. Epub 2021 Jan 28.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.

A 55-year-old female presented with binasal visual field defects and normal neuro-ophthalmic examination. Slit-lamp examination demonstrated posterior subcapsular cataracts that were located temporally in the visual axis. Due to the location of the nodal point in the eye, her visual field defect was contralateral to the opacity. Read More

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January 2021

Neuro-ophthalmic manifestations of mitochondrial disorders and their management.

Taiwan J Ophthalmol 2021 Jan-Mar;11(1):39-52. Epub 2020 Dec 4.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.

The visual system has high metabolic requirements and is therefore particularly vulnerable to mitochondrial dysfunction. The most commonly affected tissues include the extraocular muscles, photoreceptors, retinal pigment epithelium, optic nerve and visual cortex. Hence, the most common manifestations of mitochondrial disorders are progressive external ophthalmoplegia, macular pattern dystrophy, pigmentary retinopathy, optic neuropathy and retrochiasmal visual field loss. Read More

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December 2020

Case 292.

Radiology 2021 Apr;299(1):234-236

From the Departments of Ophthalmology (V.P.D., K.A.A.D., B.K.C.) and Radiology (K.L.R.), Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114; and Department of Neurology, Neuro-Ophthalmology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (B.K.C.).

History A 24-year-old right-handed woman presented to a neuro-ophthalmology clinic in Massachusetts in the summer with acute binocular diplopia when looking down and to the left, which started about 1 month earlier. Her medical history was notable for Raynaud syndrome, recurrent streptococcal pharyngitis, and an allergy to amoxicillin. Three days prior to developing diplopia, she presented to an outside emergency department due to fever, chills, and back pain. Read More

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Comparative evaluation of Octopus semi-automated kinetic perimeter with Humphrey and Goldmann perimeters in neuro-ophthalmic disorders.

Indian J Ophthalmol 2021 Apr;69(4):918-922

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: The aim of this study was to compare the performance of Octopus 900(OVF) kinetic module with Goldmann perimeter (GVF) and Humphrey 750i (HVF) perimeters in neuro-ophthalmic disorders.

Methods: During this prospective observational cross-sectional study, 17 patients (26 eyes) with neuro-ophthalmic disorders underwent visual field examination on the three perimeters. Field defects on OVF were matched with HVF and GVF for the number of quadrants involved. Read More

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Patient Harm Due to Diagnostic Error of Neuro-Ophthalmologic Conditions.

Ophthalmology 2021 Mar 11. Epub 2021 Mar 11.

Department of Ophthalmology, Emory University, Atlanta, Georgia; Department of Neurology, Emory University, Atlanta, Georgia. Electronic address:

Purpose: To prospectively examine diagnostic error of neuro-ophthalmic conditions and resultant harm at multiple sites.

Design: Prospective, cross-sectional study.

Participants: A total of 496 consecutive adult new patients seen at 3 university-based neuro-ophthalmology clinics in the United States in 2019 to 2020. Read More

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[Treatment outcomes in patients with central nervous system germinoma (neuro-ophthalmic aspects)].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(1):78-86

Burdenko Neurosurgery Center, Moscow, Russia.

Objective: The analyze the neuro-ophthalmic outcomes in patients with pineal and suprasellar germinoma after complex treatment.

Material And Methods: There were 125 patients (88 males, 37 females) with primary CNS germinoma for the period 2008-2017. All patients were divided into 3 groups depending on the tumor localization: pineal area - 62 patients, suprasellar neoplasm - 38 patients, bifocal germinoma - 25 patients. Read More

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February 2021

Unilateral Isolated Paucisymptomatic Optic Disc Edema.

J Neuroophthalmol 2020 Dec 22;Publish Ahead of Print. Epub 2020 Dec 22.

Departments of Ophthalmology (EH, RAS, JHP, MD, NJN, VB), Pediatrics (JHP), Neurology (NJN, VB), and Neurological Surgery (NJN), Emory University School of Medicine, Atlanta, Georgia.

Background: Unilateral isolated optic disc edema (UIODE) represents a challenging clinical presentation that frequently precipitates an extensive diagnostic work-up. Patients without an apparent diagnosis despite appropriate investigations are often categorized as having "papillophlebitis," an entity that is poorly defined in the existing literature. Our aim was to describe the characteristics of a series of patients with paucisymptomatic UIODE, determine the optimal diagnostic approach to such cases, and clarify the clinical features of presumed papillophlebitis. Read More

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December 2020

Umbilical cord-derived mesenchymal stem cell implantation in patients with optic atrophy.

Eur J Ophthalmol 2020 Dec 14:1120672120977824. Epub 2020 Dec 14.

Department of Ophthalmology, Acibadem Hospital, Kayseri, Turkey.

Background: Optic nerve cells can be irreversibly damaged by common various causes. Unfortunately optic nerve and retinal ganglion cells have no regenerative capacity and undergo apoptosis in case of damage. In this study, our aim is to investigate the safety and efficacy of suprachoroidal umbilical cord-derived MSCs (UC-MSCs) implantation in patients with optic atrophy. Read More

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December 2020

Methylphenidate-associated Alice in Wonderland syndrome.

Eur J Ophthalmol 2020 Dec 9:1120672120978882. Epub 2020 Dec 9.

Service d'Ophtalmologie, Hôpital Erasme, Brussels, Belgium.

Introduction: We describe the case of a child affected by typical symptoms of Alice in Wonderland syndrome (AIWS), related to the methylphenidate treatment he was taking for an attention deficit hyperactivity disorder (ADHD). To our knowledge, this is the first case of methylphenidate-associated AIWS.

Methods: Retrospective single center observational case report. Read More

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December 2020

Optic neuropathy and diplopia from thyroid eye disease: update on pathophysiology and treatment.

Curr Opin Neurol 2021 Feb;34(1):116-121

Department of Ophthalmology and Visual Sciences, Illinois Center for Thyroid Eye Disease, Illinois Eye and Ear Infirmary UIC, Chicago, Illinois, USA.

Purpose Of Review: Thyroid eye disease (TED) is a disfiguring disease that can lead to neuro-ophthalmic manifestations including diplopia and optic neuropathy. The aim of this review is to shed light on the diagnosis of TED based on clinical examination findings and diagnostic imaging. We will also discuss gold standard as well as newly emerging therapies for TED. Read More

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February 2021

Telemedicine for neuro-ophthalmology: challenges and opportunities.

Curr Opin Neurol 2021 02;34(1):61-66

Departments of Ophthalmology, Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.

Purpose Of Review: Telemedicine for neuro-ophthalmology (tele-neuro-ophthalmology) has the potential to increase access to neuro-ophthalmic care by improving efficiency and decreasing the need for long-distance travel for patients. Requirements for decreased person-to-person contacts during the COVID-19 pandemic accelerated adoption of tele-neuro-ophthalmology. This review highlights the challenges and opportunities with tele-neuro-ophthalmology. Read More

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February 2021

Outcomes of surgical resection of sphenoid-orbital meningiomas with Sonopet ultrasonic aspirator.

Orbit 2020 Sep 7:1-6. Epub 2020 Sep 7.

South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, Australia.

Purpose: Surgical resection is the mainstay of treatment for spheno-orbital meningiomas. The Sonopet® is an ultrasonic aspirator device that provides several advantages over the traditional standard suction techniques and bone drill, including decreased collateral soft tissue damage, more precise bone removal and a clearer operative field. The purpose of the study was to examine the treatment outcomes of Sonopet®-assisted resection of spheno-orbital meningiomas. Read More

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September 2020

Paracentral Acute Middle Maculopathy Mimicking Retrobulbar Optic Neuropathy.

J Neuroophthalmol 2020 Aug 28. Epub 2020 Aug 28.

Baylor College of Medicine (RAS, AGL), Houston, Texas; Department of Ophthalmology (NB, SHB, HKL, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Community Retina Group (HKL), Houston, Texas; The Houston Methodist Research Institute (HKL, AGL), Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; Texas A and M College of Medicine (AGL), Bryan, Texas; and Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa.

A 70-year-old woman presented with acute awareness of decreased color vision in her right eye. Fundus examination and a flash electroretinography (ERG) were both normal. A multifocal ERG (mfERG) however revealed foveal depression, and thinning of inner nuclear layer was noted on macular optical coherence tomography (OCT), and a diagnosis of resolved paracentral acute middle maculopathy was made. Read More

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Direct and transsynaptic retrograde degeneration and optic nerve head microvascular changes in patients with hemianopia.

Eur J Ophthalmol 2020 Aug 18:1120672120951731. Epub 2020 Aug 18.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.

Purpose: To investigate optic nerve head (ONH) microvascular changes secondary to transsynaptic retrograde degeneration (TRD), comperatively with direct retrograde degeneration and healthy controls.

Methods: Patients with hemianopia due to intracranial lesion included in the study. Intracranial lesion was categorized by location: postgeniculate (causing TRD), chiasmal (causing direct retrograde degeneration). Read More

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Estimation and interrater reliability of pupillography by digital mobile app: Digital movil pupillography app validity.

Eur J Ophthalmol 2020 Aug 18:1120672120949752. Epub 2020 Aug 18.

Facultad de medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico.

Objective: The examination of pupillary light reflexes is widely employed to evaluate the autonomic system's balance, ocular, and neurological conditions, typically evaluated by qualitative observation. To describe and evaluate the inter-rater reliability and agreement of pupillometric values obtained with a novel semi-automatic mobile pupillography app.

Methods: Two examiners and two graders perform the measurements with an android app which corrects the device-face distance, measure the maximum contraction of the pupil, and calculates its slope, in a hospital room setting with three levels of environmental light intensity: <100, 101 to 200, and 201 to 300 lux, at 200, 400, 600, 900, 1200, and 1500 milliseconds. Read More

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Subjective intermittent colour vision loss as the initial presentation of chronic myeloid leukemia.

Am J Ophthalmol Case Rep 2020 Sep 8;19:100817. Epub 2020 Jul 8.

Department of Ophthalmology, University of Ottawa, The Ottawa Hospital and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Purpose: To report a case of subjective intermittent loss of bilateral colour vision and episodic white-out vision in a patient with undiagnosed chronic myeloid leukemia (CML).

Observations: A patient initially diagnosed with diabetic retinopathy presented with a chief complaint of subjective intermittent loss of colour vision in both eyes, as well as intermittent bilateral white-out vision. These symptoms previously went uninvestigated until a thorough history revealed concurrent constitutional symptoms including recent night sweats and fevers. Read More

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September 2020

Survey of Telehealth Adoption by Neuro-ophthalmologists During the COVID-19 Pandemic: Benefits, Barriers, and Utility.

J Neuroophthalmol 2020 09;40(3):346-355

Departments of Ophthalmology (HEM) and Neurology & Neurological Sciences (HEM), Stanford University, Palo Alto, California; Department of Ophthalmology (KEL, MWK), Indiana University School of Medicine, Indianapolis, Indiana; Ophthalmology Service (KEL), Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Indiana; and Departments of Neurology and Neurosurgery (MWK), Indiana University School of Medicine, Indianapolis, Indiana.

Background: During the COVID-19 pandemic, telehealth modalities have come to prominence as a strategy for providing patient care when in-person care provision opportunities are limited. The degree of adoption by neuro-ophthalmologists has not been quantified.

Methods: Telehealth utilization pre-COVID-19 and peri-COVID-19 was surveyed among practicing neuro-ophthalmologists in and outside the United States using an online platform. Read More

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September 2020

Pediatric ophthalmology, strabismus and neuro-ophthalmology practice in the COVID-19 era: All India Ophthalmological Society guidelines.

Indian J Ophthalmol 2020 Jul;68(7):1300-1305

Centre For Sight, New Delhi, India.

The COVID-19 Pandemic has prompted substantial changes in the way ophthalmology is practiced globally. General guidelines on safe ophthalmic practice have been issued by various bodies across the globe including the All India Ophthalmological Society. While these are suitable to ophthalmology overall, they are not entirely suitable to a subspecialty practice, particularly pediatric ophthalmology, strabismus and neuro-ophthalmology, which entails dealing with children, surgery under general anesthesia and managing possible life threatening situations. Read More

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Surgical management of a case of contractile peripapillary staphyloma with retinal detachment and macular hole.

Eur J Ophthalmol 2020 Apr 30:1120672120920227. Epub 2020 Apr 30.

Clínica Unidad Láser del Atlántico/Grupo oftalmológico Abdala Figuerola, Portoazul Clinic, Barranquilla, Colombia.

A healthy 4-year-old male presented a fundus examination with a unilateral contractile peripapillary staphyloma surrounded by redundant retina and retinal pigment epithelium atrophy. Five years later, best-corrected visual acuity decreased to hand motion due to a retinal detachment with macular hole. One month after first vitrectomy, scleral buckle and intraocular gas, retina re-detached. Read More

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[Saccadic abnormalities and clinical significance in patients with neuromyelitis optica spectrum disorder].

Zhonghua Yi Xue Za Zhi 2020 Apr;100(13):1028-1032

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To characterize the ocular saccadic abnormality in neuromyelitis optica spectrum disorder (NMOSD) patients, and explore the relationship between ocular saccadic abnormality and the overall disability and visual function state. For the 110 consecutive NMOSD patients who visited the Department of Neurology of Beijing Tongren Hospital from July 2015 to July 2017, a 120 Hz spatial resolution infrared video nystagmus system was used to perform a quantitative horizontal saccade examination. All patients were assessed for overall disability status using the extended disability status scale (EDSS). Read More

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Coexistence of papilledema and pseudopapilledema after remission of idiopathic intracranial hypertension by bariatric surgery.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):157-159

Instituto de Olhos, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil.

A 37-year-old woman complained of headaches following bilateral visual loss in the past two years. She was obese and had undergone bariatric surgery three months earlier, followed by a considerable weight loss. Neuro-ophthalmic examination revealed a bilateral swollen optic disk. Read More

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Normative ocular data for juvenile and adult Japanese quail (Coturnix japonica).

Vet Ophthalmol 2020 May 26;23(3):526-533. Epub 2020 Feb 26.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

Objective: To obtain normative ocular data for Japanese quail as they mature from juveniles to adults.

Animals Studied: Twenty-six captive Japanese quail comprising thirteen males and thirteen females, free of ocular disease, were included in the study.

Procedures: Ophthalmic reference values were measured in both eyes at 1 and 5 months of age. Read More

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Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update.

NPJ Microgravity 2020 7;6. Epub 2020 Feb 7.

12Department of Emergency Medicine, Baylor College of Medicine, Houston, TX USA.

Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity associated findings collectively define the "Spaceflight Associated Neuro-ocular Syndrome" (SANS). We compare and contrast prior published work on SANS by the National Aeronautics and Space Administration's (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. Read More

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February 2020

Localizing Thalamomesencephalic Afferent and Efferent Pupillary Defects.

J Neuroophthalmol 2021 Mar;41(1):e136-e138

Department of Ophthalmology and Visual Sciences (AS, LJL, AGL), University of Texas Medical Branch, Galveston, Texas; Department of Ophthalmology (RRS, AGL), Baylor College of Medicine, Houston, Texas; Department of Ophthalmology (ATK, BAAO, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology (AGL), Neurology, and Neurosurgery, Weill Cornell Medicine, New York, New York; Section of Ophthalmology (AGL), University of Texas Maryland Anderson Cancer Center, Houston, Texas; and Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Abstract: A 42-year-old Algerian man presented for binocular oblique diplopia, hypersomnolence with drop attacks, bilateral hearing loss, and thoracic pain. He had a right thalamomesencephalic hemorrhage due to an underlying cavernous malformation treated with subtotal surgical resection. On neuro-ophthalmic examination, the patient had a left relative afferent pupillary defect and a right oculosympathetic efferent pupillary defect (i. Read More

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Effect of topical administration of 0.1% diclofenac sodium ophthalmic solution at four frequencies on intraocular pressure in healthy Beagles.

Am J Vet Res 2020 Jan;81(1):41-46

Objective: To evaluate effects of topical ophthalmic administration of diclofenac on intraocular pressure (IOP) when applied at 4 frequencies to eyes of Beagles.

Animals: 8 ophthalmologically normal Beagles.

Procedures: The study involved four 5-day experimental periods each separated by a 16-day washout period. Read More

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January 2020

Neuro-ophthalmic Disease in Pediatric Glaucoma Practice.

J Glaucoma 2020 Feb;29(2):117-123

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.

Precis: Pediatric glaucoma referral to neuro-ophthalmology has a high yield for diagnosing neurological disease and neuroimaging in this cohort often uncovers intracranial abnormalities.

Purpose: Multiple studies have examined the utility of neuro-ophthalmology referrals in an adult glaucoma patient population. No similar studies in the pediatric glaucoma population have been completed. Read More

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February 2020

Collapsin Response-Mediator Protein 5-Associated Retinitis, Vitritis, and Optic Disc Edema.

Ophthalmology 2020 02 20;127(2):221-229. Epub 2019 Sep 20.

Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota; Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota. Electronic address:

Purpose: Collapsin response-mediator protein 5 (CRMP5) immunoglobulin G (IgG) has been associated with paraneoplastic optic neuritis, vitritis, retinitis, or a combination thereof, but few reports of these findings exist in the literature. We reviewed the neuro-ophthalmic findings and visual outcomes in a large series of CRMP5 IgG-positive patients to characterize further its clinical phenotype and response to treatment.

Design: Retrospective case series. Read More

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February 2020

Study of prevalence of ocular manifestations in HIV positive patients.

Nepal J Ophthalmol 2019 Jan;11(21):11-18

Department of Ophthalmology, SHKM, GMC Nalhar, Nuh.

Introduction: HIV/AIDS is a disorder which affects multiple systems in our body but ophthalmic manifestations do occur in 70-80% of patients sometime during their lifetime. Eye is affected either directly by HIV virus or indirectly through various opportunistic infections. HIV related ophthalmic manifestations are wide and can affect any part of eye from a dnexal disorders to posterior segment diseases including the optic nerve and the optic tract. Read More

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January 2019