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    20207 results match your criteria Neurilemmoma

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    Low CT Attenuation Values of Sinonasal Benign Tumours Relative to the Brainstem Identify Schwannomas.
    ORL J Otorhinolaryngol Relat Spec 2018 Apr 17;80(1):41-50. Epub 2018 Apr 17.
    Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
    Objectives: On computed tomography (CT), sinonasal schwannoma displays as a soft-tissue mass without any distinctive features. Our aim was to define the radiological criteria for distinguishing schwannoma from other sinonasal benign tumours.

    Methods: We retrospectively identified consecutive patients who were pathologically diagnosed with benign sinonasal tumours between 2007 and 2016. Read More

    A novel technique to identify the nerve of origin in head and neck schwannomas.
    J Laryngol Otol 2018 Apr 18:1-5. Epub 2018 Apr 18.
    Department of Otolaryngology - Head and Neck Surgery,University of Nevada Las Vegas School of Medicine,USA.
    Objective: Identifying the nerve of origin in head and neck schwannomas is a diagnostic challenge. Surgical management leads to a risk of permanent deficit. Accurate identification of the nerve would improve operative planning and patient counselling. Read More

    Intraspinal schwannoma and neurogenic bladder.
    Ann R Coll Surg Engl 2018 Apr 15;100(4):e69-e72. Epub 2018 Mar 15.
    Department of Surgery, Taipei Tzu Chi Hospital and Buddhist Tzu Chi University , Taiwan.
    Most lumbar intradural schwannomas present initially as radiculopathies with sensory disturbances. However, neurogenic bladder dysfunction may be one of the earliest manifestations and can cause long-term disability. We present the case of a patient with a L3-4 schwannoma (newly diagnosed owing to recurrent urinary retention and urinary tract infection) who finally underwent surgical resection. Read More

    [Entrapment neuropathy in the foot revealing schwannoma of the superficial peroneal nerve: outcome of conservative surgical treatment].
    Pan Afr Med J 2017 19;28:161. Epub 2017 Oct 19.
    Service de Chirurgie Orthopédique et de Traumatologie, CHU Ibn Sina, Université Mohammed V, Souissi, Rabat, Maroc.
    We report the case of a 61-year old patient with no particular previous history who complained of pain with paraesthesias at the level of the anterolateral compartment of the left leg irradiating to the dorsal side of the ankle and the foot which lasted over six months. These pains were made worse by effort. Clinical examination showed partial sensitivity deficit and positive Tinel's sign in the territory of the superficial peroneal nerve (A). Read More

    Middle mediastinal schwannoma concealed by asthma and GORD.
    BMJ Case Rep 2018 Mar 13;2018. Epub 2018 Mar 13.
    Department of Surgery, University of Santo Tomas Hospital, Manila, Philippines.
    Neurogenic tumours of the mediastinum in adults occur most often at the posterior mediastinum, majority of which are benign of nerve sheath in origin. A 72-year-old woman, known asthmatic, presented with chronic symptoms of hoarseness, dysphagia, chest heaviness, easy fatigability, cough, epigastric pain, feeling of abdominal fullness and choking with food intake and at a supine position. Treated for other disorders, routine chest X-ray incidentally found a homogenous convex radiodensity at the right paratracheal area; mass which was also observed with CT and 18F-fludeoxyglucose-positron emission tomography/CT scan studies. Read More

    A standardised pathway for the surveillance of stable vestibular schwannoma.
    Ann R Coll Surg Engl 2018 Mar;100(3):216-220
    King's College Hospital NHS Foundation Trust, UK , UK.
    Introduction Conservative management of patients with a stable vestibular schwannoma (VS) places a significant burden on National Health Service (NHS) resources and yet patients' surveillance management is often inconsistent. Our unit has developed a standardised pathway to guide surveillance imaging of patients with stable VS. In this article, we provide the basis for our imaging protocol by reviewing the measurement, natural history and growth patterns of VS, and we present a cost analysis of implementing the pathway both regionally and nationally. Read More

    Benign diaphragmatic neurilemmoma mimicking a left adrenal cyst.
    Turk J Urol 2018 Jan 19;44(1):87-90. Epub 2017 Dec 19.
    Department of Urology, Sawai Man Singh Medical College, Jaipur, Rajasthan.
    Neurilemmomas are benign, slow growing, encapsulated nerve sheath tumor. These tumors arise from the schwann cells of neural crest. Neurilemmomas can manifest in various form according to site, extent and severity of involvement of organ. Read More

    A case report of rectal schwannoma treated with laparoscopic proctectomy.
    Medicine (Baltimore) 2018 Feb;97(7):e9866
    Department of General Surgery.
    Rationale: Schwannomas of gastrointestinal tracts are rare and difficult to detect preoperatively because of negative results of endoscopic and imaging examinations. Here, we reported a case of rectal schwannoma, which was diagnosed by immunohistochemical staining after laparoscopic protectomy.

    Patient Concerns: A 61-year-old woman complained of a 1-month history of difficulty in defecation and irregularly abdominal discomfort during her physical checkup in our hospital. Read More

    A Rare Case of Primary Intrapulmonary Neurilemmoma Diagnosed in a 43-Year-Old Asymptomatic Man with a Well-defined Intrapulmonary Mass.
    Front Oncol 2018 30;8:11. Epub 2018 Jan 30.
    5th Pulmonology Department, Athens Chest Hospital "Sotiria", Athens, Greece.
    Neurilemmoma (NL), also termed schwannoma, presents as a well-circumscribed and encapsulated mass in the human body and is almost always solitary. CT scan of a patient with NL shows a round, ovoid, or lobulated well-demarcated solid mass of soft tissue density. Primary intrathoracic neurogenic tumors location varies. Read More

    Vestibular schwannomas: Accuracy of tumor volume estimated by ice cream cone formula using thin-sliced MR images.
    PLoS One 2018 13;13(2):e0192411. Epub 2018 Feb 13.
    Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan.
    Purpose: We estimated the volume of vestibular schwannomas by an ice cream cone formula using thin-sliced magnetic resonance images (MRI) and compared the estimation accuracy among different estimating formulas and between different models.

    Methods: The study was approved by a local institutional review board. A total of 100 patients with vestibular schwannomas examined by MRI between January 2011 and November 2015 were enrolled retrospectively. Read More

    Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome.
    Br J Neurosurg 2018 Feb 12:1-10. Epub 2018 Feb 12.
    b Radiological Sciences, Division of Clinical Neuroscience , University of Nottingham , Nottingham , UK.
    Background: Despite previous identification of pre-operative clinical and radiological predictors of post-operative paediatric cerebellar mutism syndrome (CMS), a unifying pre-operative risk stratification model for use during surgical consent is currently lacking. The aim of the project is to develop a simple imaging-based pre-operative risk scoring scheme to stratify patients in terms of post-operative CMS risk.

    Methods: Pre-operative radiological features were recorded for a retrospectively assembled cohort of 89 posterior fossa tumour patients from two major UK treatment centers (age 2-23yrs; gender 28 M, 61 F; diagnosis: 38 pilocytic astrocytoma, 32 medulloblastoma, 12 ependymoma, 1 high grade glioma, 1 pilomyxoid astrocytoma, 1 atypical teratoid rhabdoid tumour, 1 hemangioma, 1 neurilemmoma, 2 oligodendroglioma). Read More

    High-Throughput Tabular Data Processor - Platform independent graphical tool for processing large data sets.
    PLoS One 2018 12;13(2):e0192858. Epub 2018 Feb 12.
    Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland.
    High-throughput technologies generate considerable amount of data which often requires bioinformatic expertise to analyze. Here we present High-Throughput Tabular Data Processor (HTDP), a platform independent Java program. HTDP works on any character-delimited column data (e. Read More

    "Ancient" schwannoma of the submandibular gland: A case report and literature review.
    Medicine (Baltimore) 2017 Dec;96(51):e9134
    Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University.
    Rationale: Schwannomas are solitary neurogenic tumors that arise from cells of the neural sheath. Ancient schwannoma is a relatively rare variant of schwannoma, characterized by increased cellularity and atypia. These cellular changes could be confusing and make the accurate pathologic diagnosis difficult. Read More

    Pain correlates with germline mutation in schwannomatosis.
    Medicine (Baltimore) 2018 Feb;97(5):e9717
    Department of Neurology.
    Schwannomatosis has been linked to germline mutations in the SMARCB1 and LZTR1 genes, and is frequently associated with pain.In a cohort study, we assessed the mutation status of 37 patients with clinically diagnosed schwannomatosis and compared to clinical data, whole body MRI (WBMRI), visual analog pain scale, and Short Form 36 (SF-36) bodily pain subscale.We identified a germline mutation in LZTR1 in 5 patients (13. Read More

    Targeted next-generation sequencing of malignant peripheral nerve sheath tumor of the pterygopalatine fossa with intracranial metastatic recurrence.
    Medicine (Baltimore) 2018 Jan;97(4):e9636
    Department of Neurosurgery.
    Malignant peripheral nerve sheath tumor (MPNST) is an uncommon neoplasm that rarely involves the head and neck region. Intracranial MPNSTs unrelated to cranial nerves are highly malignant tumors with poor overall survival, probably because of infiltrating growth into surrounding brain tissue. The pathogenesis of MPNST remains unclear. Read More

    Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor.
    J Cancer Res Clin Oncol 2018 Mar 13;144(3):519-529. Epub 2018 Jan 13.
    Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, 7 Debinki Street, 80-211, Gdansk, Poland.
    Purpose: Selected cell-cycle regulators and extracellular matrix proteins were found to play roles in malignant peripheral nerve sheath tumor (MPNST) biology. We aimed to analyze whether initial tumor tissue expressions of survivin, p53, cyclin D1, osteopontin (OPN) and fibronectin (FN) correlate with the response to neo-adjuvant CHT (naCHT) in children with advanced inoperable MPNST.

    Methods: The study included 26 children with MPNST (M/F 14/12, median age 130 months) treated in Polish centers of pediatric oncology between 1992 and 2013. Read More

    Renal hybrid oncocytic/chromophobe tumor associated with multiple schwannomas: Case report and literature review.
    Medicine (Baltimore) 2017 Dec;96(48):e8939
    Department of Urology.
    Rationale: Renal hybrid oncocytic/chromophobe tumors (HOCTs) are benign tumors containing a mixture of cells with features of chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO). Sporadic HOCT, which means HOCT occurs in patients without Birt-Hogg-Dubé syndrome (BHDS) or renal oncocytosis, is extremely rare. In this article, we would report a new case of a patient with both sporadic HOCT and multiple Schwannomas, which is even rarer than simplex sporadic HOCT. Read More

    Giant schwannoma of the hard palate: a literature review and report of an uncommon case.
    Gen Dent 2018 Jan-Feb;66(1):62-65
    Schwannomas (also known as neurilemomas) are benign tumors that arise from the Schwann cells of the nerve sheath. While they seldom occur in the oral cavity, the tongue is the most common site. Palatal schwannomas are extremely rare. Read More

    Neurilemmoma of Maxillary Alveolus: A Rare Case Report and Review of Literature.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S285-S288
    Department of Oral and Maxillofacial Surgery, Vinayaka Missions Sankarachariyar Dental College and Hospital, Salem, Tamil Nadu, India.
    Schwannomas or neurilemmomas are benign, slow growing, usually solitary and encapsulated tumor, originating from Schwann cells of the nerve sheath. Intraoral schwannomas account for 1% of head and neck region and are commonly seen at the base of the tongue. Most of the literature, reports of schwannomas in the tongue region are common. Read More

    Chronic Calf Pain Caused by Fibroma-Induced Chronic Inflammation Around the Tibial and Peroneal Nerves that Was Misdiagnosed as Centralized Neuropathic Pain: A Case Report.
    Pain Pract 2017 Dec 28. Epub 2017 Dec 28.
    Department of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea.
    Introduction: The etiology of calf pain varies widely; therefore, it is difficult to diagnose and requires careful history taking and physical examination by primary care unit physicians. Because ultrasonography is easy to perform, cheap, and readily available to physicians during a routine consultation, it is the first choice of modality for the evaluation of calf pain. However, simple inflammation around the nerve should also be considered as a possible etiology. Read More

    Primary tracheal schwannoma a review of a rare entity: current understanding of management and followup.
    J Cardiothorac Surg 2017 Nov 28;12(1):105. Epub 2017 Nov 28.
    Department of General Surgery and Urology, Jordan University of Science and Technology, Faculty of Medicine, King Abdullah University Hospital, Irbid, 22110, Jordan.
    Background: Neurogenic tumors of the tracheobronchial tree are extremely rare and include neurofibroma and schwannoma. We report a case of primary recurrent tracheal schwannoma causing obstructive airway symptoms.

    Case Presentation: A 60-year-old man presented with obstructive airway symptoms due to recurrent tracheal schwannoma. Read More

    Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.
    Int J Surg Pathol 2018 May 26;26(3):221-228. Epub 2017 Nov 26.
    1 Seoul National University, Seoul, Korea.
    Background: Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis is very important because the clinical course of each disease, even within the same diseases, is quite variable. Read More

    Expression of the BRAF mutation in sporadic neurofibromas of the upper extremity.
    Exp Mol Pathol 2017 12 21;103(3):276-278. Epub 2017 Nov 21.
    Department of Plastic Surgery, University of California, Irvine, United States.
    The pathogenesis of neurofibromas is poorly understood outside of neurofibromatosis (NF). The BRAF proto-oncogene has been implicated in malignant peripheral nerve sheath tumors (PNSTs), however its role in neurofibromas has not been described. In this study, we identify a BRAF mutation in a 61-year old non-NF patient with a history of sporadic and recurrent neurofibromas localized to the right upper extremity. Read More

    Distinguishing Benign from Malignant Circumscribed Orbital Tumors in Children.
    Semin Ophthalmol 2018 16;33(1):116-125. Epub 2017 Nov 16.
    b Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School , Boston , MA , USA.
    An orbital neoplasm in children is an uncommon clinical finding. Clinical suspicion should be based on many factors, including its location, the nature of onset, associated systemic signs and symptoms, family and social histories, examination findings, and radiographic characteristics. We present two cases of young children of similar age with a rapid-onset orbital mass. Read More

    Harlequin syndrome and Horner syndrome after neck schwannoma excision in a pediatric patient: A case report.
    Medicine (Baltimore) 2017 Nov;96(45):e8548
    Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea.
    Rationale: Harlequin syndrome is an extremely rare benign condition characterized by unilateral facial flushing and sweating.

    Patient Concern: An 11-year-old boy presented with complaint of a right neck mass of 1-month duration.

    Diagnosis: The preoperative diagnosis was neurogenic tumor of vagus nerve or sympathetic nerve. Read More

    MEK inhibitors enhance therapeutic response towards ATRA in NF1 associated malignant peripheral nerve sheath tumors (MPNST) in-vitro.
    PLoS One 2017 13;12(11):e0187700. Epub 2017 Nov 13.
    Institute of Neuropathology, University Hospital Münster, Münster, Germany.
    Objective: Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome characterized by an increased risk of malignant peripheral nerve sheath tumors (MPNST). Chemotherapy of MPNST is still insufficient. In this study, we investigated whether human tumor Schwann cells derived from NF1 associated MPNST respond to all-trans retinoic acid (ATRA). Read More

    Intraparotid Schwannoma Masquerading as Primary Spindle Cell Tumour of Parotid: A Diagnostic Pitfall.
    J Cytol 2017 Oct-Dec;34(4):221-223
    Department of Pathology, Maulana Azad Medical College, New Delhi, India.
    A middle-aged female presented with a painless, slowly growing mass in the left parotid region; fine needle aspiration cytology from the mass showed uniform spindle cells in a fibrillary background with some cells showing palisading. A cytodiagnosis of schwannoma was given, which was further confirmed on biopsy. Read More

    Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.
    J Natl Cancer Inst 2017 Aug;109(8)
    Rare Tumor Initiative, Laboratory of Pathology, and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC; Department of Neurology, Johns Hopkins Hospital, Baltimore, MD; Neurofibromatosis Center, Department of Neurology Guy's Hospital London, London, UK; Department of Neurology, Washington University School of Medicine, St. Louis, MO; Department of Human Genetics, University of Leuven, Leuven, Belgium; Hunstman Cancer Institute, University of Utah, Salt Lake City, UT; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH; Bill and Melinda Gates Foundation, Seattle, WA; Children's Tumor Foundation, New York, NY; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
    Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft tissue sarcoma for which the only effective therapy is surgery. In 2016, an international meeting entitled "MPNST State of the Science: Outlining a Research Agenda for the Future" was convened to establish short- and long-term research priorities. Key recommendations included the: 1) development of standardized, cost-efficient fluorodeoxyglucose positron emission tomography and whole-body magnetic resonance imaging guidelines to evaluate masses concerning for MPNST; 2) development of better understanding and histologic criteria for the transformation of a plexiform neurofibroma to MPNST; 3) establishment of a centralized database to collect genetic, genomic, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from MPNST subspecialty centers in a standardized manner; 4) creation of accurate mouse models to study the plexiform neurofibroma-to-MPNST transition, MPNST metastasis, and drug resistance; 5) use of trial designs that minimize regulatory requirements, maximize availability to patients, consider novel secondary end points, and study patients with newly diagnosed disease. Read More

    Experience of operative treatment in 27 patients with intraspinal neurilemmoma.
    Oncol Lett 2017 Oct 23;14(4):4817-4821. Epub 2017 Aug 23.
    Department of Orthopaedics, The Second People's Hospital of Changzhou, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China.
    To investigate the clinical outcomes of posterior laminectomy on intraspinal neurilemmoma. Twenty-seven patients with intraspinal neurilemmoma admitted to the Second People's Hospital of Changzhou Affiliated to Nanjing Medical University from January 2010 to October 2015 were selected, and they received posterior laminectomy, and there were 5 patients whose nerve root and tumor were removed together because they could not be separated; 17 patients receiving total laminectomy or semi-laminectomy combined with facetectomy on the affected side were treated with spinal dynamic pedicle screw fixation or replantation of lamina or bone graft fusion and internal fixation. The patients were followed up regularly to observe the clinical outcomes after operation. Read More

    Endoscopic endonasal approach for mass resection of the pterygopalatine fossa.
    Clinics (Sao Paulo) 2017 Oct;72(9):554-561
    Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University, University Hospital Motol, V Úvalu 84, 150 06, Prague 5, Czech Republic.
    Objectives: Access to the pterygopalatine fossa is very difficult due to its complex anatomy. Therefore, an open approach is traditionally used, but morbidity is unavoidable. To overcome this problem, an endoscopic endonasal approach was developed as a minimally invasive procedure. Read More

    [Surgical Treatment of a Giant Olfactory Groove Schwannoma:A Case Report].
    No Shinkei Geka 2017 Oct;45(10):919-928
    Department of Neurosurgery, National Defense Medical College.
    Schwannomas originating from the olfactory nerve are extremely rare because the olfactory nerve does not normally contain Schwann cells. We describe a case of a giant schwannoma of the olfactory groove. A 73-year-old woman presented with anosmia persisting for 10 months. Read More

    Diagnosis and Treatment of Laryngeal Schwannoma: A Systematic Review.
    Otolaryngol Head Neck Surg 2018 Feb 17;158(2):222-231. Epub 2017 Oct 17.
    1 Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS San Raffaele Hospital, Vita-Salute University, Milan, Italy.
    Objective This review summarizes the clinical features, diagnostic workup, and surgical treatment of laryngeal schwannoma with the aim of providing guidance for the management of this rare disease. The collated data allowed the statistical testing of several hypotheses, including the efficacy of endoscopic vs open surgical intervention and the usefulness of preoperative biopsy. Data Sources PubMed, Google Scholar, Cochrane, and SCOPUS. Read More

    Internal Auditory Canal Tumor as an Incidental Finding on a Choline PET/CT Scan in a Prostate Cancer Patient.
    Clin Nucl Med 2017 Dec;42(12):e513-e515
    From the *Department of Medical Physics, Faculty of Medicine, National and Kapodistrian University of Athens; and †Department of PET/CT, Hygeia Hospital, Athens, Greece.
    An 84-year-old man with a history of prostate cancer, treated with radiotherapy, presented with an increase in PSA levels. F-choline PET/CT showed foci of increased choline uptake in L4 and L5 vertebrae, suggestive of bone metastases and another focus in the right cerebellopontine angle. A brain MRI revealed a focus of intense contrast enhancement in the same region, consistent with an acoustic neuroma. Read More

    Clinical Features and Surgical Treatment of Schwannoma Affecting the Base of the Tongue: A Systematic Review.
    Int Arch Otorhinolaryngol 2017 Oct 13;21(4):408-413. Epub 2017 Feb 13.
    Department of Clinical and Translational Science, Creighton University School of Medicine Ringgold Standard Institution, Omaha, Nebraska, United States.
     Schwannomas of the head and neck account for 25-40% of all cases, with presentation at the base of the tongue as the most frequent site for intraoral tumors.  Here, a systematic review was conducted to include 15 cases of patients with schwannoma of the base of the tongue.  Most patients presented with a single, painless, well-encapsulated nodule at the base of the tongue. Read More

    Novel enriched pathways in superficial malignant peripheral nerve sheath tumours and spindle/desmoplastic melanomas.
    J Pathol 2018 Jan;244(1):97-106
    Department of Pathology, Section of Dermatopathology, the University of Texas - MD Anderson Cancer Center, Houston, TX, USA.
    Superficial malignant peripheral nerve sheath tumour (MPNST) is a rare, soft tissue neoplasm that shares morphological features and some molecular events with spindle/desmoplastic melanoma (SDM). Herein, we sought to identify molecular targets for therapy by using targeted RNA/DNA sequencing and gene expression of key immunological players. DNA and RNA from formalin-fixed paraffin-embedded tissue were extracted and processed. Read More

    Cerebellopontine angle astrocytoma producing Bruns nystagmus mimicking vestibular schwannoma.
    Can J Ophthalmol 2017 10 16;52(5):e181-e182. Epub 2017 May 16.
    Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Tex; Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, N.Y.; Department of Ophthalmology, The University of Iowa, Iowa City, Ia; Department of Ophthalmology, Baylor College of Medicine, Houston, Tex; Department of Ophthalmology, University of Texas Medical Branch, Galveston, Tex; Section of Ophthalmology, UT MD Anderson Cancer Center, Houston, Tex; Department of Ophthalmology, University at Buffalo (SUNY), Buffalo, N.Y. Electronic address:

    [Analysis of NF2 gene mutations in intraspinal Schwannomas].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Oct;34(5):637-641
    Department of Neurosurgery, Fuzhou Second Hospital, Xiamen University, Fuzhou, Fujian 350007, China.
    Objective: To explore the correlation between intraspinal Schwannomas and mutations of the NF2 gene.

    Methods: Samples from 20 patients with sporadic intraspinal Schwannomas were collected and subjected NF2 gene mutation detection by PCR amplification and Sanger sequencing.

    Results: Four de novo frameshifting mutations of the NF2 gene were discovered in the tumor tissues, which included c. Read More

    Palatal ancient schwannoma: optical, immunohistochemical and ultrastructural study with literature review.
    Eur Arch Otorhinolaryngol 2017 Dec 3;274(12):4195-4202. Epub 2017 Oct 3.
    Department of Pathology, Valencia University and La Fe University Hospital, Avda. Fernando Abril Martorell 106, Torre A, 2ª Planta, 46026, Valencia, Spain.
    Schwannoma or neurilemmoma is a benign encapsulated slow-growing tumor that originates from a Schwann cell of a nerve, and is rare at intraoral locations. Different histological variants of schwannomas have been described, of these degenerative or ancient schwannoma is probably one of the least common in the oral cavity with only 16 previously reported cases, of which only one has been described in palatal location. Although ancient schwannoma shows particular characteristics, it is difficult to diagnose based on clinical and imaging appearance alone; as a result, morphological examination assisted by ancillary techniques is necessary to establish a definite diagnosis. Read More

    Intradural Spinal Tumors-Review of Postoperative Outcomes Comparing Intramedullary and Extramedullary Tumors from a Single Institution's Experience.
    World Neurosurg 2018 Jan 30;109:e229-e232. Epub 2017 Sep 30.
    Division of Neurosurgery, Department of General Surgery, National University Hospital, National University Health Systems, Singapore.
    Background: Intradural spinal tumors are rare and can be classified into extramedullary or intramedullary. They commonly present with symptoms such as intractable back pain or neurologic deficits. We retrospectively reviewed 91 cases of intradural spinal tumors that underwent surgery in our institution from 2011 to 2016 and assessed their clinical outcomes. Read More

    The value of intraoperative EABRs in auditory brainstem implantation.
    Int J Pediatr Otorhinolaryngol 2017 Oct 9;101:158-163. Epub 2017 Aug 9.
    New York University School of Medicine, NYU Langone Medical Center, United States.
    Objective: To compare the intraoperative electrically evoked auditory brainstem response (EABR) morphologies between neurofibromatosis II (NF2) adult auditory brainstem implant (ABI) recipients who had auditory percepts post-operatively and those who did not and between NF2 adult ABI recipients and non-NF2 pediatric ABI recipients.

    Methods: This was a retrospective case series at a single tertiary academic referral center examining all ABI recipients from 1994 to 2016, which included 34 NF2 adults and 11 non-NF2 children. The morphologies of intraoperative EABRs were evaluated for the number of waveforms showing a response, the number of positive peaks in those responses, and the latencies of each of these peaks. Read More

    Salvage rates and prognostic factors after relapse in children and adolescents with malignant peripheral nerve sheath tumors.
    Pediatr Blood Cancer 2018 Feb 19;65(2). Epub 2017 Sep 19.
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy.
    Background: Malignant peripheral nerve sheath tumor (MPNST) is one of the most common nonrhabdomyosarcoma soft tissue sarcomas encountered in pediatric age, and it is generally characterized by poor outcome, particularly for relapsing patients.

    Materials And Methods: This study considered 73 patients <21 years of age with relapsing MPNST observed among 120 patients enrolled in Italian pediatric protocols from 1979 to 2004. With the aim of possibly establishing a risk-adapted stratification, patients' outcome was examined using univariate and multivariate analysis based on clinical features at onset, first-line treatments, clinical findings at the time of first relapse, and second-line treatments. Read More

    [A malignant peripheral nerve sheath tumor developed from the auditory nerve: a case report and a literature review].
    Zh Vopr Neirokhir Im N N Burdenko 2017;81(4):95-100
    Burdenko Neurosurgical Institute, Moscow, Russia.
    We present a rare clinical case of a patient with a malignant peripheral nerve sheath tumor developed from the auditory nerve as well as a literature review, including 30 reported cases of this disease. Read More

    Anti-VEGF treatment improves neurological function in tumors of the nervous system.
    Exp Neurol 2018 Jan 11;299(Pt B):326-333. Epub 2017 Sep 11.
    Edwin Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:
    Research of various diseases of the nervous system has shown that VEGF has direct neuroprotective effects in the central and peripheral nervous systems, and indirect effects on improving neuronal vessel perfusion which leads to nerve protection. In the tumors of the nervous system, VEGF plays a critical role in tumor angiogenesis and tumor progression. The effect of anti-VEGF treatment on nerve protection and function has been recently reported - by normalizing the tumor vasculature, anti-VEGF treatment is able to relieve nerve edema and deliver oxygen more efficiently into the nerve, thus reducing nerve damage and improving nerve function. Read More

    High-resolution ultrasonography and shear-wave sonoelastography of a cystic radial nerve Schwannoma.
    J Ultrasound 2017 Sep 6;20(3):261-266. Epub 2017 Jun 6.
    Department of Radiology, Logan University, 1851 Schoettler Road, Chesterfield, MO 63017 USA.
    Peripheral nerve tumors are often evaluated with magnetic resonance imaging (MRI), although there are many advantages offered with high-resolution ultrasonography (HRUS). This case report emphasizes the value of HRUS in the diagnosis and management of a patient with a cystic radial nerve Schwannoma. In addition, information on tumor stiffness, obtained with shear-wave sonoelastography (SWE), is presented. Read More

    Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens.
    Am J Clin Pathol 2017 Aug;148(2):179-189
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
    Objectives: Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3). We evaluated the utility of H3K27me3 immunohistochemistry for distinguishing MPNST from its cytomorphologic mimics. Read More

    [A Case of Primary Schwannoma of the Urinary Bladder].
    Hinyokika Kiyo 2017 Aug;63(8):323-328
    The Department of Urology and Andrology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba.
    A 68-year-old woman presented with a bladder tumor. She was asymptomatic, and the tumor was incidentally detected with radiological imaging performed during treatment of cervical cancer. Magnetic resonance imaging and computed tomography revealed a solitary submucosal tumor located in the anterior wall of the urinary bladder, with homogeneous contrast enhancement. Read More

    A Systematic Review of Radiosurgery Versus Surgery for Neurofibromatosis Type 2 Vestibular Schwannomas.
    World Neurosurg 2018 Jan 4;109:47-58. Epub 2017 Sep 4.
    Department of Neurosurgery, University of California, Los Angeles, Los Angeles, California, USA; Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, California, USA; Department of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA. Electronic address:
    Objective: Neurofibromatosis type 2 (NF2) is an autosomal dominant disease characterized by bilateral vestibular schwannomas (VSs). NF2-associated VSs (NF2-VSs) are routinely treated with microsurgery; however, stereotactic radiosurgery (SRS) has emerged as an effective alternative in recent decades. To elucidate the role of SRS in NF2-VSs, a systematic review of the literature was conducted to compare outcomes of SRS versus surgery. Read More

    Successful treatment with doxorubicin and ifosfamide for mediastinal malignant peripheral nerve sheath tumor with loss of H3K27me3 expression.
    Thorac Cancer 2017 11 6;8(6):720-723. Epub 2017 Sep 6.
    Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
    Malignant peripheral nerve sheath tumor (MPNST) in the thorax is an extremely rare disease, and half of all cases of MPNST are associated with neurofibromatosis type I. Sporadic intrathoracic MPNST is difficult to diagnose and treat. Because of the rarity of intrathoracic MPNST, the optimal method of diagnosis and the efficacy of chemotherapy are unknown. Read More

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