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    A Rare Case of Primary Intrapulmonary Neurilemmoma Diagnosed in a 43-Year-Old Asymptomatic Man with a Well-defined Intrapulmonary Mass.
    Front Oncol 2018 30;8:11. Epub 2018 Jan 30.
    5th Pulmonology Department, Athens Chest Hospital "Sotiria", Athens, Greece.
    Neurilemmoma (NL), also termed schwannoma, presents as a well-circumscribed and encapsulated mass in the human body and is almost always solitary. CT scan of a patient with NL shows a round, ovoid, or lobulated well-demarcated solid mass of soft tissue density. Primary intrathoracic neurogenic tumors location varies. Read More

    Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome.
    Br J Neurosurg 2018 Feb 12:1-10. Epub 2018 Feb 12.
    b Radiological Sciences, Division of Clinical Neuroscience , University of Nottingham , Nottingham , UK.
    Background: Despite previous identification of pre-operative clinical and radiological predictors of post-operative paediatric cerebellar mutism syndrome (CMS), a unifying pre-operative risk stratification model for use during surgical consent is currently lacking. The aim of the project is to develop a simple imaging-based pre-operative risk scoring scheme to stratify patients in terms of post-operative CMS risk.

    Methods: Pre-operative radiological features were recorded for a retrospectively assembled cohort of 89 posterior fossa tumour patients from two major UK treatment centers (age 2-23yrs; gender 28 M, 61 F; diagnosis: 38 pilocytic astrocytoma, 32 medulloblastoma, 12 ependymoma, 1 high grade glioma, 1 pilomyxoid astrocytoma, 1 atypical teratoid rhabdoid tumour, 1 hemangioma, 1 neurilemmoma, 2 oligodendroglioma). Read More

    "Ancient" schwannoma of the submandibular gland: A case report and literature review.
    Medicine (Baltimore) 2017 Dec;96(51):e9134
    Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University.
    Rationale: Schwannomas are solitary neurogenic tumors that arise from cells of the neural sheath. Ancient schwannoma is a relatively rare variant of schwannoma, characterized by increased cellularity and atypia. These cellular changes could be confusing and make the accurate pathologic diagnosis difficult. Read More

    Pain correlates with germline mutation in schwannomatosis.
    Medicine (Baltimore) 2018 Feb;97(5):e9717
    Department of Neurology.
    Schwannomatosis has been linked to germline mutations in the SMARCB1 and LZTR1 genes, and is frequently associated with pain.In a cohort study, we assessed the mutation status of 37 patients with clinically diagnosed schwannomatosis and compared to clinical data, whole body MRI (WBMRI), visual analog pain scale, and Short Form 36 (SF-36) bodily pain subscale.We identified a germline mutation in LZTR1 in 5 patients (13. Read More

    Targeted next-generation sequencing of malignant peripheral nerve sheath tumor of the pterygopalatine fossa with intracranial metastatic recurrence.
    Medicine (Baltimore) 2018 Jan;97(4):e9636
    Department of Neurosurgery.
    Malignant peripheral nerve sheath tumor (MPNST) is an uncommon neoplasm that rarely involves the head and neck region. Intracranial MPNSTs unrelated to cranial nerves are highly malignant tumors with poor overall survival, probably because of infiltrating growth into surrounding brain tissue. The pathogenesis of MPNST remains unclear. Read More

    Renal hybrid oncocytic/chromophobe tumor associated with multiple schwannomas: Case report and literature review.
    Medicine (Baltimore) 2017 Dec;96(48):e8939
    Department of Urology.
    Rationale: Renal hybrid oncocytic/chromophobe tumors (HOCTs) are benign tumors containing a mixture of cells with features of chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO). Sporadic HOCT, which means HOCT occurs in patients without Birt-Hogg-Dubé syndrome (BHDS) or renal oncocytosis, is extremely rare. In this article, we would report a new case of a patient with both sporadic HOCT and multiple Schwannomas, which is even rarer than simplex sporadic HOCT. Read More

    Giant schwannoma of the hard palate: a literature review and report of an uncommon case.
    Gen Dent 2018 Jan-Feb;66(1):62-65
    Schwannomas (also known as neurilemomas) are benign tumors that arise from the Schwann cells of the nerve sheath. While they seldom occur in the oral cavity, the tongue is the most common site. Palatal schwannomas are extremely rare. Read More

    Neurilemmoma of Maxillary Alveolus: A Rare Case Report and Review of Literature.
    J Pharm Bioallied Sci 2017 Nov;9(Suppl 1):S285-S288
    Department of Oral and Maxillofacial Surgery, Vinayaka Missions Sankarachariyar Dental College and Hospital, Salem, Tamil Nadu, India.
    Schwannomas or neurilemmomas are benign, slow growing, usually solitary and encapsulated tumor, originating from Schwann cells of the nerve sheath. Intraoral schwannomas account for 1% of head and neck region and are commonly seen at the base of the tongue. Most of the literature, reports of schwannomas in the tongue region are common. Read More

    Chronic Calf Pain Caused by Fibroma-Induced Chronic Inflammation Around the Tibial and Peroneal Nerves that Was Misdiagnosed as Centralized Neuropathic Pain: A Case Report.
    Pain Pract 2017 Dec 28. Epub 2017 Dec 28.
    Department of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea.
    Introduction: The etiology of calf pain varies widely; therefore, it is difficult to diagnose and requires careful history taking and physical examination by primary care unit physicians. Because ultrasonography is easy to perform, cheap, and readily available to physicians during a routine consultation, it is the first choice of modality for the evaluation of calf pain. However, simple inflammation around the nerve should also be considered as a possible etiology. Read More

    Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.
    Int J Surg Pathol 2017 Nov 1:1066896917742722. Epub 2017 Nov 1.
    1 Seoul National University, Seoul, Korea.
    Background: Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis is very important because the clinical course of each disease, even within the same diseases, is quite variable. Read More

    Expression of the BRAFmutation in sporadic neurofibromas of the upper extremity.
    Exp Mol Pathol 2017 12 21;103(3):276-278. Epub 2017 Nov 21.
    Department of Plastic Surgery, University of California, Irvine, United States.
    The pathogenesis of neurofibromas is poorly understood outside of neurofibromatosis (NF). The BRAF proto-oncogene has been implicated in malignant peripheral nerve sheath tumors (PNSTs), however its role in neurofibromas has not been described. In this study, we identify a BRAF mutation in a 61-year old non-NF patient with a history of sporadic and recurrent neurofibromas localized to the right upper extremity. Read More

    Distinguishing Benign from Malignant Circumscribed Orbital Tumors in Children.
    Semin Ophthalmol 2018 16;33(1):116-125. Epub 2017 Nov 16.
    b Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School , Boston , MA , USA.
    An orbital neoplasm in children is an uncommon clinical finding. Clinical suspicion should be based on many factors, including its location, the nature of onset, associated systemic signs and symptoms, family and social histories, examination findings, and radiographic characteristics. We present two cases of young children of similar age with a rapid-onset orbital mass. Read More

    Harlequin syndrome and Horner syndrome after neck schwannoma excision in a pediatric patient: A case report.
    Medicine (Baltimore) 2017 Nov;96(45):e8548
    Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea.
    Rationale: Harlequin syndrome is an extremely rare benign condition characterized by unilateral facial flushing and sweating.

    Patient Concern: An 11-year-old boy presented with complaint of a right neck mass of 1-month duration.

    Diagnosis: The preoperative diagnosis was neurogenic tumor of vagus nerve or sympathetic nerve. Read More

    MEK inhibitors enhance therapeutic response towards ATRA in NF1 associated malignant peripheral nerve sheath tumors (MPNST) in-vitro.
    PLoS One 2017 13;12(11):e0187700. Epub 2017 Nov 13.
    Institute of Neuropathology, University Hospital Münster, Münster, Germany.
    Objective: Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome characterized by an increased risk of malignant peripheral nerve sheath tumors (MPNST). Chemotherapy of MPNST is still insufficient. In this study, we investigated whether human tumor Schwann cells derived from NF1 associated MPNST respond to all-trans retinoic acid (ATRA). Read More

    Intraparotid Schwannoma Masquerading as Primary Spindle Cell Tumour of Parotid: A Diagnostic Pitfall.
    J Cytol 2017 Oct-Dec;34(4):221-223
    Department of Pathology, Maulana Azad Medical College, New Delhi, India.
    A middle-aged female presented with a painless, slowly growing mass in the left parotid region; fine needle aspiration cytology from the mass showed uniform spindle cells in a fibrillary background with some cells showing palisading. A cytodiagnosis of schwannoma was given, which was further confirmed on biopsy. Read More

    Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.
    J Natl Cancer Inst 2017 Aug;109(8)
    Rare Tumor Initiative, Laboratory of Pathology, and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC; Department of Neurology, Johns Hopkins Hospital, Baltimore, MD; Neurofibromatosis Center, Department of Neurology Guy's Hospital London, London, UK; Department of Neurology, Washington University School of Medicine, St. Louis, MO; Department of Human Genetics, University of Leuven, Leuven, Belgium; Hunstman Cancer Institute, University of Utah, Salt Lake City, UT; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH; Bill and Melinda Gates Foundation, Seattle, WA; Children's Tumor Foundation, New York, NY; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
    Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft tissue sarcoma for which the only effective therapy is surgery. In 2016, an international meeting entitled "MPNST State of the Science: Outlining a Research Agenda for the Future" was convened to establish short- and long-term research priorities. Key recommendations included the: 1) development of standardized, cost-efficient fluorodeoxyglucose positron emission tomography and whole-body magnetic resonance imaging guidelines to evaluate masses concerning for MPNST; 2) development of better understanding and histologic criteria for the transformation of a plexiform neurofibroma to MPNST; 3) establishment of a centralized database to collect genetic, genomic, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from MPNST subspecialty centers in a standardized manner; 4) creation of accurate mouse models to study the plexiform neurofibroma-to-MPNST transition, MPNST metastasis, and drug resistance; 5) use of trial designs that minimize regulatory requirements, maximize availability to patients, consider novel secondary end points, and study patients with newly diagnosed disease. Read More

    Experience of operative treatment in 27 patients with intraspinal neurilemmoma.
    Oncol Lett 2017 Oct 23;14(4):4817-4821. Epub 2017 Aug 23.
    Department of Orthopaedics, The Second People's Hospital of Changzhou, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China.
    To investigate the clinical outcomes of posterior laminectomy on intraspinal neurilemmoma. Twenty-seven patients with intraspinal neurilemmoma admitted to the Second People's Hospital of Changzhou Affiliated to Nanjing Medical University from January 2010 to October 2015 were selected, and they received posterior laminectomy, and there were 5 patients whose nerve root and tumor were removed together because they could not be separated; 17 patients receiving total laminectomy or semi-laminectomy combined with facetectomy on the affected side were treated with spinal dynamic pedicle screw fixation or replantation of lamina or bone graft fusion and internal fixation. The patients were followed up regularly to observe the clinical outcomes after operation. Read More

    Endoscopic endonasal approach for mass resection of the pterygopalatine fossa.
    Clinics (Sao Paulo) 2017 Oct;72(9):554-561
    Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University, University Hospital Motol, V Úvalu 84, 150 06, Prague 5, Czech Republic.
    Objectives: Access to the pterygopalatine fossa is very difficult due to its complex anatomy. Therefore, an open approach is traditionally used, but morbidity is unavoidable. To overcome this problem, an endoscopic endonasal approach was developed as a minimally invasive procedure. Read More

    Diagnosis and Treatment of Laryngeal Schwannoma: A Systematic Review.
    Otolaryngol Head Neck Surg 2018 Feb 17;158(2):222-231. Epub 2017 Oct 17.
    1 Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS San Raffaele Hospital, Vita-Salute University, Milan, Italy.
    Objective This review summarizes the clinical features, diagnostic workup, and surgical treatment of laryngeal schwannoma with the aim of providing guidance for the management of this rare disease. The collated data allowed the statistical testing of several hypotheses, including the efficacy of endoscopic vs open surgical intervention and the usefulness of preoperative biopsy. Data Sources PubMed, Google Scholar, Cochrane, and SCOPUS. Read More

    Clinical Features and Surgical Treatment of Schwannoma Affecting the Base of the Tongue: A Systematic Review.
    Int Arch Otorhinolaryngol 2017 Oct 13;21(4):408-413. Epub 2017 Feb 13.
    Department of Clinical and Translational Science, Creighton University School of Medicine Ringgold Standard Institution, Omaha, Nebraska, United States.
     Schwannomas of the head and neck account for 25-40% of all cases, with presentation at the base of the tongue as the most frequent site for intraoral tumors. Here, a systematic review was conducted to include 15 cases of patients with schwannoma of the base of the tongue. Most patients presented with a single, painless, well-encapsulated nodule at the base of the tongue. Read More

    Novel enriched pathways in superficial malignant peripheral nerve sheath tumours and spindle/desmoplastic melanomas.
    J Pathol 2018 Jan;244(1):97-106
    Department of Pathology, Section of Dermatopathology, the University of Texas - MD Anderson Cancer Center, Houston, TX, USA.
    Superficial malignant peripheral nerve sheath tumour (MPNST) is a rare, soft tissue neoplasm that shares morphological features and some molecular events with spindle/desmoplastic melanoma (SDM). Herein, we sought to identify molecular targets for therapy by using targeted RNA/DNA sequencing and gene expression of key immunological players. DNA and RNA from formalin-fixed paraffin-embedded tissue were extracted and processed. Read More

    Cerebellopontine angle astrocytoma producing Bruns nystagmus mimicking vestibular schwannoma.
    Can J Ophthalmol 2017 10 16;52(5):e181-e182. Epub 2017 May 16.
    Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Tex; Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, N.Y.; Department of Ophthalmology, The University of Iowa, Iowa City, Ia; Department of Ophthalmology, Baylor College of Medicine, Houston, Tex; Department of Ophthalmology, University of Texas Medical Branch, Galveston, Tex; Section of Ophthalmology, UT MD Anderson Cancer Center, Houston, Tex; Department of Ophthalmology, University at Buffalo (SUNY), Buffalo, N.Y. Electronic address:

    Palatal ancient schwannoma: optical, immunohistochemical and ultrastructural study with literature review.
    Eur Arch Otorhinolaryngol 2017 Dec 3;274(12):4195-4202. Epub 2017 Oct 3.
    Department of Pathology, Valencia University and La Fe University Hospital, Avda. Fernando Abril Martorell 106, Torre A, 2ª Planta, 46026, Valencia, Spain.
    Schwannoma or neurilemmoma is a benign encapsulated slow-growing tumor that originates from a Schwann cell of a nerve, and is rare at intraoral locations. Different histological variants of schwannomas have been described, of these degenerative or ancient schwannoma is probably one of the least common in the oral cavity with only 16 previously reported cases, of which only one has been described in palatal location. Although ancient schwannoma shows particular characteristics, it is difficult to diagnose based on clinical and imaging appearance alone; as a result, morphological examination assisted by ancillary techniques is necessary to establish a definite diagnosis. Read More

    Intradural Spinal Tumors-Review of Postoperative Outcomes Comparing Intramedullary and Extramedullary Tumors from a Single Institution's Experience.
    World Neurosurg 2018 Jan 30;109:e229-e232. Epub 2017 Sep 30.
    Division of Neurosurgery, Department of General Surgery, National University Hospital, National University Health Systems, Singapore.
    Background: Intradural spinal tumors are rare and can be classified into extramedullary or intramedullary. They commonly present with symptoms such as intractable back pain or neurologic deficits. We retrospectively reviewed 91 cases of intradural spinal tumors that underwent surgery in our institution from 2011 to 2016 and assessed their clinical outcomes. Read More

    The value of intraoperative EABRs in auditory brainstem implantation.
    Int J Pediatr Otorhinolaryngol 2017 Oct 9;101:158-163. Epub 2017 Aug 9.
    New York University School of Medicine, NYU Langone Medical Center, United States.
    Objective: To compare the intraoperative electrically evoked auditory brainstem response (EABR) morphologies between neurofibromatosis II (NF2) adult auditory brainstem implant (ABI) recipients who had auditory percepts post-operatively and those who did not and between NF2 adult ABI recipients and non-NF2 pediatric ABI recipients.

    Methods: This was a retrospective case series at a single tertiary academic referral center examining all ABI recipients from 1994 to 2016, which included 34 NF2 adults and 11 non-NF2 children. The morphologies of intraoperative EABRs were evaluated for the number of waveforms showing a response, the number of positive peaks in those responses, and the latencies of each of these peaks. Read More

    Salvage rates and prognostic factors after relapse in children and adolescents with malignant peripheral nerve sheath tumors.
    Pediatr Blood Cancer 2018 Feb 19;65(2). Epub 2017 Sep 19.
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy.
    Background: Malignant peripheral nerve sheath tumor (MPNST) is one of the most common nonrhabdomyosarcoma soft tissue sarcomas encountered in pediatric age, and it is generally characterized by poor outcome, particularly for relapsing patients.

    Materials And Methods: This study considered 73 patients <21 years of age with relapsing MPNST observed among 120 patients enrolled in Italian pediatric protocols from 1979 to 2004. With the aim of possibly establishing a risk-adapted stratification, patients' outcome was examined using univariate and multivariate analysis based on clinical features at onset, first-line treatments, clinical findings at the time of first relapse, and second-line treatments. Read More

    Anti-VEGF treatment improves neurological function in tumors of the nervous system.
    Exp Neurol 2018 Jan 11;299(Pt B):326-333. Epub 2017 Sep 11.
    Edwin Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:
    Research of various diseases of the nervous system has shown that VEGF has direct neuroprotective effects in the central and peripheral nervous systems, and indirect effects on improving neuronal vessel perfusion which leads to nerve protection. In the tumors of the nervous system, VEGF plays a critical role in tumor angiogenesis and tumor progression. The effect of anti-VEGF treatment on nerve protection and function has been recently reported - by normalizing the tumor vasculature, anti-VEGF treatment is able to relieve nerve edema and deliver oxygen more efficiently into the nerve, thus reducing nerve damage and improving nerve function. Read More

    High-resolution ultrasonography and shear-wave sonoelastography of a cystic radial nerve Schwannoma.
    J Ultrasound 2017 Sep 6;20(3):261-266. Epub 2017 Jun 6.
    Department of Radiology, Logan University, 1851 Schoettler Road, Chesterfield, MO 63017 USA.
    Peripheral nerve tumors are often evaluated with magnetic resonance imaging (MRI), although there are many advantages offered with high-resolution ultrasonography (HRUS). This case report emphasizes the value of HRUS in the diagnosis and management of a patient with a cystic radial nerve Schwannoma. In addition, information on tumor stiffness, obtained with shear-wave sonoelastography (SWE), is presented. Read More

    Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens.
    Am J Clin Pathol 2017 Aug;148(2):179-189
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
    Objectives: Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3). We evaluated the utility of H3K27me3 immunohistochemistry for distinguishing MPNST from its cytomorphologic mimics. Read More

    [A Case of Primary Schwannoma of the Urinary Bladder].
    Hinyokika Kiyo 2017 Aug;63(8):323-328
    The Department of Urology and Andrology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba.
    A 68-year-old woman presented with a bladder tumor. She was asymptomatic, and the tumor was incidentally detected with radiological imaging performed during treatment of cervical cancer. Magnetic resonance imaging and computed tomography revealed a solitary submucosal tumor located in the anterior wall of the urinary bladder, with homogeneous contrast enhancement. Read More

    A Systematic Review of Radiosurgery Versus Surgery for Neurofibromatosis Type 2 Vestibular Schwannomas.
    World Neurosurg 2018 Jan 4;109:47-58. Epub 2017 Sep 4.
    Department of Neurosurgery, University of California, Los Angeles, Los Angeles, California, USA; Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, California, USA; Department of Head and Neck Surgery, University of California, Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA. Electronic address:
    Objective: Neurofibromatosis type 2 (NF2) is an autosomal dominant disease characterized by bilateral vestibular schwannomas (VSs). NF2-associated VSs (NF2-VSs) are routinely treated with microsurgery; however, stereotactic radiosurgery (SRS) has emerged as an effective alternative in recent decades. To elucidate the role of SRS in NF2-VSs, a systematic review of the literature was conducted to compare outcomes of SRS versus surgery. Read More

    The promise of signal transduction in genetically driven sarcomas of the nerve.
    Exp Neurol 2018 Jan 30;299(Pt B):317-325. Epub 2017 Aug 30.
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United States. Electronic address:
    Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome. Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas arising from peripheral nerve sheaths, and the most commonly lethal feature associated with NF1. The hallmark of NF1 and NF1-related MPNST is the loss of neurofibromin expression. Read More

    Characterization of Head-Trunk Coordination Deficits After Unilateral Vestibular Hypofunction Using Wearable Sensors.
    JAMA Otolaryngol Head Neck Surg 2017 Oct;143(10):1008-1014
    Doctoral Program in Physical Therapy, US Army-Baylor University, Ft Sam Houston, Texas.
    Importance: Individuals with vestibular hypofunction acutely restrict head motion to reduce symptoms of dizziness and nausea. This restriction results in abnormal decoupling of head motion from trunk motion, but the character, magnitude, and persistence of these deficits are unclear.

    Objective: To use wearable inertial sensors to quantify the extent of head and trunk kinematic abnormalities in the subacute stage after resection of vestibular schwannoma (VS) and the particular areas of deficit in head-trunk motion. Read More

    Identification of the Facial Nerve in Relation to Vestibular Schwannoma Using Preoperative Diffusion Tensor Tractography and Intraoperative Tractography-Integrated Neuronavigation System.
    World Neurosurg 2017 Nov 18;107:669-677. Epub 2017 Aug 18.
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address:
    Background: Preoperative visualization of the facial nerve could help neurosurgeons to prevent facial nerve injury during vestibular schwannoma surgery. Some studies have addressed diffusion tensor tractography (DTT) for preoperative identification of the facial nerve. However, few studies have focused on tractography-integrated neuronavigation for DTT verification. Read More

    Predictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma.
    World Neurosurg 2017 Nov 5;107:175-184. Epub 2017 Aug 5.
    Division of Stereotactic and Functional Neurosurgery, Department of Neurosurgery, Yonsei Gamma Knife Center, Yonsei University College of Medicine, Seoul, Korea. Electronic address:
    Objective: Gamma Knife radiosurgery (GKS) for the treatment of vestibular schwannoma (VS) introduces risks to the facial nerve and auditory perception and may involve post-treatment complications such as pseudoprogression, hydrocephalus, and other cranial neuropathies. This study of patients with VS who underwent GKS investigated radiosurgical results, focusing on post-treatment complications and identifying the factors that predict such complications.

    Methods: We undertook a retrospective review of all VS patients treated with the Perfexion Leksell Gamma Knife between November 2007 and October 2010 at our institution. Read More

    Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development.
    Nat Commun 2017 08 21;8(1):300. Epub 2017 Aug 21.
    Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California Los Angeles, Los Angeles, CA, 90095, USA.
    Germline mutations of the SMARCB1 gene predispose to two distinct tumor syndromes: rhabdoid tumor predisposition syndrome, with malignant pediatric tumors mostly developing in brain and kidney, and familial schwannomatosis, with adulthood benign tumors involving cranial and peripheral nerves. The mechanisms by which SMARCB1 germline mutations predispose to rhabdoid tumors versus schwannomas are still unknown. Here, to understand the origin of these two types of SMARCB1-associated tumors, we generated different tissue- and developmental stage-specific conditional knockout mice carrying Smarcb1 and/or Nf2 deletion. Read More

    A Rare Case of Vagus Nerve Schwannoma Presenting as a Neck Mass.
    Am J Case Rep 2017 Aug 21;18:908-911. Epub 2017 Aug 21.
    Department of Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Jamaica, NY, USA.
    BACKGROUND Vagus nerve schwannoma is a benign neoplasm that usually presents as an asymptomatic slow growing mass, and its presentation as a neck mass is rare. The diagnosis can be difficult to make and complete surgical excision is challenging due to the proximity of the vagus nerve fibers from which it originates. The most common symptom associated with vagus nerve schwannoma arising in the neck is hoarseness due to vocal cord palsy. Read More

    Recovery of Tinnitus and Sensorineural Hearing Loss Due to Lysis of Arachnoid Adhesions in the Posterior Cranial Fossa: Is There a Novel Etiology in Neurotological Disorders?
    J Int Adv Otol 2017 Aug;13(2):295-297
    Clinic of Ear Nose Throat and Head Neck Surgery, İstanbul Medipol University, İstanbul, Turkey.
    We reported the recovery of sensorineural hearing loss and tinnitus in a 22-year-old man after complete removal of intracranial portion of jugular foramen schwannoma via the retrosigmoid approach. The aim of this case report was to present the excision of a large jugular foramen schwannoma via the retrosigmoid approach and to describe the improvement of sensorineural hearing loss related to arachnoid inflammations due to chronic arachnoiditis after suboccipital craniectomy. The recovery of sensorineural hearing loss and tinnitus after release of arachnoid adhesions may indicate the clinical significance of these adhesions or arachnoiditis, which should also be considered and investigated in the etiology of other neurotological diseases. Read More

    Intralabyrinthine Vestibular Schwannoma Responsive to Intratympanic Gentamicin Treatment.
    J Int Adv Otol 2017 Aug;13(2):285-288
    Department Neuroscience Mental Health and Sensory Organs (NESMOS), Sapienza University, Rome, Italy.
    Intralabyrinthine schwannoma (ILS) is a rare benign tumor that affects the ends of cochlear and vestibular nerves. In a majority of the cases, it occurs with unilateral progressive sensorineural hearing loss. Less frequent symptoms include tinnitus, imbalance, vertigo, or fullness. Read More

    Eustachian Tube Obliteration and its Effect on Rhinoliquorrhea in Translabyrinthine Vestibular Schwannoma Excision.
    J Int Adv Otol 2017 Aug;13(2):191-194
    Department of Otolaryngology, Head and Neck Surgery, University of Montreal, Montreal, Qc, Canada.
    Objective: Rhinoliquorrhea is defined as a cerebrospinal fluid leakage from the nose. Our objective in this study is to determine the reduction of rhinoliquorrhea rates by Eustachian tube (ET) obliteration in the context of a translabyrinthine approach performed following vestibular schwannoma (VS) excision.

    Materials And Methods: This is a prospective study achieved in a tertiary-care center where the chart review revealed 94 VS operated by the translabyrinthine approach between 2009 and 2015. Read More

    Complications of the Middle Cranial Fossa Approach for Acoustic Neuroma Removal.
    J Int Adv Otol 2017 Aug;13(2):186-190
    Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Wuerzburg, Germany.
    Objective: To analyze postoperative complications after microsurgery for acoustic neuroma (AN) via the middle fossa approach (MFA).

    Materials And Methods: In total, 203 consecutive patients of a tertiary skull base referral center at a university hospital were included in this retrospective chart and database analysis. All patients had undergone primary microsurgery at the Otorhinolaryngology department via MFA between December 2005 and October 2014. Read More

    Hypoglossal Canal Lesions: Distinctive Imaging Features and Simple Diagnostic Algorithm.
    AJR Am J Roentgenol 2017 Nov 16;209(5):1119-1127. Epub 2017 Aug 16.
    3 Department of Diagnostic Radiology, Mayo Clinic, Phoenix, AZ.
    Objective: The objective of this study is to compare the prevalence of hypoglossal canal lesions and identify differentiating imaging features.

    Materials And Methods: A 15-year retrospective review of lesions of the hypoglossal nerve and hypoglossal canal, excluding those in patients with metastasis or prior head and neck cancer and those treated with radiation or surgery, was performed. Clinical findings and lesion imaging features were documented. Read More

    Ascending Colon Schwannoma an Unusual Cause of Acute Lower Gastrointestinal Bleeding.
    S D Med 2017 Jan;70(1):33-37
    Department of Surgery, University of South Dakota Sanford School of Medicine.
    This is a case report of a 61-year-old female who presented with acute lower gastrointestinal bleeding resulting from a schwannoma involving the ascending colon. The patient was successfully treated with laparoscopic hemicolectomy. Schwannoma involving the large bowel is a rare entity; only around 90 cases of colonic schwannomas are reported in world literature. Read More

    Schwannoma of the hypoglossal nerve: Review of the literature based on an illustrative case.
    Mol Clin Oncol 2017 Aug 21;7(2):288-294. Epub 2017 Jun 21.
    Department of Surgery, IRCCS-Azienda Ospedaliera Universitaria San Martino-IST, University of Genoa, I-16132 Genoa, Italy.
    Schwannomas are benign tumours that originate from the myelin sheath of peripheral nerves. They are characterised by a slow growth tendency. Benign schwannomas represent 35% of the head and neck district tumours. Read More

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