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    Intraparotid Schwannoma Masquerading as Primary Spindle Cell Tumour of Parotid: A Diagnostic Pitfall.
    J Cytol 2017 Oct-Dec;34(4):221-223
    Department of Pathology, Maulana Azad Medical College, New Delhi, India.
    A middle-aged female presented with a painless, slowly growing mass in the left parotid region; fine needle aspiration cytology from the mass showed uniform spindle cells in a fibrillary background with some cells showing palisading. A cytodiagnosis of schwannoma was given, which was further confirmed on biopsy. Read More

    Experience of operative treatment in 27 patients with intraspinal neurilemmoma.
    Oncol Lett 2017 Oct 23;14(4):4817-4821. Epub 2017 Aug 23.
    Department of Orthopaedics, The Second People's Hospital of Changzhou, Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China.
    To investigate the clinical outcomes of posterior laminectomy on intraspinal neurilemmoma. Twenty-seven patients with intraspinal neurilemmoma admitted to the Second People's Hospital of Changzhou Affiliated to Nanjing Medical University from January 2010 to October 2015 were selected, and they received posterior laminectomy, and there were 5 patients whose nerve root and tumor were removed together because they could not be separated; 17 patients receiving total laminectomy or semi-laminectomy combined with facetectomy on the affected side were treated with spinal dynamic pedicle screw fixation or replantation of lamina or bone graft fusion and internal fixation. The patients were followed up regularly to observe the clinical outcomes after operation. Read More

    Diagnosis and Treatment of Laryngeal Schwannoma: A Systematic Review.
    Otolaryngol Head Neck Surg 2017 Oct 1:194599817735508. Epub 2017 Oct 1.
    1 Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS San Raffaele Hospital, Vita-Salute University, Milan, Italy.
    Objective This review summarizes the clinical features, diagnostic workup, and surgical treatment of laryngeal schwannoma with the aim of providing guidance for the management of this rare disease. The collated data allowed the statistical testing of several hypotheses, including the efficacy of endoscopic vs open surgical intervention and the usefulness of preoperative biopsy. Data Sources PubMed, Google Scholar, Cochrane, and SCOPUS. Read More

    Clinical Features and Surgical Treatment of Schwannoma Affecting the Base of the Tongue: A Systematic Review.
    Int Arch Otorhinolaryngol 2017 Oct 13;21(4):408-413. Epub 2017 Feb 13.
    Department of Clinical and Translational Science, Creighton University School of Medicine Ringgold Standard Institution, Omaha, Nebraska, United States.
    Introduction  Schwannomas of the head and neck account for 25-40% of all cases, with presentation at the base of the tongue as the most frequent site for intraoral tumors. Objectives  Here, a systematic review was conducted to include 15 cases of patients with schwannoma of the base of the tongue. Data Synthesis  Most patients presented with a single, painless, well-encapsulated nodule at the base of the tongue. Read More

    Palatal ancient schwannoma: optical, immunohistochemical and ultrastructural study with literature review.
    Eur Arch Otorhinolaryngol 2017 Dec 3;274(12):4195-4202. Epub 2017 Oct 3.
    Department of Pathology, Valencia University and La Fe University Hospital, Avda. Fernando Abril Martorell 106, Torre A, 2ª Planta, 46026, Valencia, Spain.
    Schwannoma or neurilemmoma is a benign encapsulated slow-growing tumor that originates from a Schwann cell of a nerve, and is rare at intraoral locations. Different histological variants of schwannomas have been described, of these degenerative or ancient schwannoma is probably one of the least common in the oral cavity with only 16 previously reported cases, of which only one has been described in palatal location. Although ancient schwannoma shows particular characteristics, it is difficult to diagnose based on clinical and imaging appearance alone; as a result, morphological examination assisted by ancillary techniques is necessary to establish a definite diagnosis. Read More

    The value of intraoperative EABRs in auditory brainstem implantation.
    Int J Pediatr Otorhinolaryngol 2017 Oct 9;101:158-163. Epub 2017 Aug 9.
    New York University School of Medicine, NYU Langone Medical Center, United States.
    Objective: To compare the intraoperative electrically evoked auditory brainstem response (EABR) morphologies between neurofibromatosis II (NF2) adult auditory brainstem implant (ABI) recipients who had auditory percepts post-operatively and those who did not and between NF2 adult ABI recipients and non-NF2 pediatric ABI recipients.

    Methods: This was a retrospective case series at a single tertiary academic referral center examining all ABI recipients from 1994 to 2016, which included 34 NF2 adults and 11 non-NF2 children. The morphologies of intraoperative EABRs were evaluated for the number of waveforms showing a response, the number of positive peaks in those responses, and the latencies of each of these peaks. Read More

    High-resolution ultrasonography and shear-wave sonoelastography of a cystic radial nerve Schwannoma.
    J Ultrasound 2017 Sep 6;20(3):261-266. Epub 2017 Jun 6.
    Department of Radiology, Logan University, 1851 Schoettler Road, Chesterfield, MO 63017 USA.
    Peripheral nerve tumors are often evaluated with magnetic resonance imaging (MRI), although there are many advantages offered with high-resolution ultrasonography (HRUS). This case report emphasizes the value of HRUS in the diagnosis and management of a patient with a cystic radial nerve Schwannoma. In addition, information on tumor stiffness, obtained with shear-wave sonoelastography (SWE), is presented. Read More

    Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens.
    Am J Clin Pathol 2017 Aug;148(2):179-189
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
    Objectives: Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3). We evaluated the utility of H3K27me3 immunohistochemistry for distinguishing MPNST from its cytomorphologic mimics. Read More

    Characterization of Head-Trunk Coordination Deficits After Unilateral Vestibular Hypofunction Using Wearable Sensors.
    JAMA Otolaryngol Head Neck Surg 2017 Oct;143(10):1008-1014
    Doctoral Program in Physical Therapy, US Army-Baylor University, Ft Sam Houston, Texas.
    Importance: Individuals with vestibular hypofunction acutely restrict head motion to reduce symptoms of dizziness and nausea. This restriction results in abnormal decoupling of head motion from trunk motion, but the character, magnitude, and persistence of these deficits are unclear.

    Objective: To use wearable inertial sensors to quantify the extent of head and trunk kinematic abnormalities in the subacute stage after resection of vestibular schwannoma (VS) and the particular areas of deficit in head-trunk motion. Read More

    Schwannoma of the hypoglossal nerve: Review of the literature based on an illustrative case.
    Mol Clin Oncol 2017 Aug 21;7(2):288-294. Epub 2017 Jun 21.
    Department of Surgery, IRCCS-Azienda Ospedaliera Universitaria San Martino-IST, University of Genoa, I-16132 Genoa, Italy.
    Schwannomas are benign tumours that originate from the myelin sheath of peripheral nerves. They are characterised by a slow growth tendency. Benign schwannomas represent 35% of the head and neck district tumours. Read More

    Association of Genetic Predisposition With Solitary Schwannoma or Meningioma in Children and Young Adults.
    JAMA Neurol 2017 Sep;74(9):1123-1129
    Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England.
    Importance: Meningiomas and schwannomas are usually sporadic, isolated tumors occurring in adults older than 60 years and are rare in children and young adults. Multiple schwannomas and/or meningiomas are more frequently associated with a tumor suppressor syndrome and, accordingly, trigger genetic testing, whereas solitary tumors do not. Nevertheless, apparently sporadic tumors in young patients may herald a genetic syndrome. Read More

    Oddities Sporadic Neurofibroma of the Urinary Bladder. A Case Report.
    Urol Case Rep 2017 Sep 12;14:42-44. Epub 2017 Jul 12.
    Department of Urology, Bicêtre Hospital, Le Kremlin Bicêtre, France.
    Neurofibromas of the urinary bladder are an exceedingly rare entity and are considered mostly in conjunction with the disease of neurofibromatosis type 1. The fortuitous discovery of vesical plexiform neurofibromas without other stigmata of the disease is presented in a 57-year-old male patient. The course of his condition, modalities of investigation and a non-precedent treatment plan are demonstrated. Read More

    Schwannoma of the tongue: a case report with review of literature.
    Maxillofac Plast Reconstr Surg 2017 Dec 5;39(1):17. Epub 2017 Jul 5.
    Department of Oral and Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University, SeoWon-gu Chungdae-ro 1, Cheong-ju, 28644 South Korea.
    Background: Schwannomas (or neurilemmomas) of the tongue are benign, usually solitary, encapsulated masses derived from Schwann cells. Clinical evidence indicates that schwannoma is painless and slow growing. In general, schwannoma is treated by surgical excision. Read More

    An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis.
    Cancer Res 2017 Sep 20;77(18):5026-5038. Epub 2017 Jul 20.
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
    Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the development of multiple tumors in the central nervous system, most notably schwannomas, and meningiomas. Mutational inactivation of the NF2 gene encoding the protein Merlin is found in most sporadic and inherited schwannomas, but the molecular mechanisms underlying neoplastic changes in schwannoma cells remain unclear. We report here that Nf2-deficient cells display elevated expression levels of key enzymes involved in lipogenesis and that this upregulation is caused by increased activity of Torc1. Read More

    [Evaluation of a new closure technique of large defects after endoscopic full-thickness resection].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Jul;20(7):775-781
    Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Objective: To investigate the security and efficacy of a new endoscopic closure method of large defects after endoscopic full-thickness resection (EFTR) double purse-string suture using two endoloops and metallic clips via single-channel endoscopy.

    Methods: Clinical data of 23 cases with submucosal tumors (SMT) who received endoscopic resection from June 2015 to July 2016 in our National Cancer Center were collected. For gastric and esophageal SMTs or the mucosa layer injured during submucosal tunneling endoscopic resection (STER), double purse-string suture was conducted after EFTR. Read More

    Giant Solitary Schwannoma of Submandibular Salivary Gland-A Rare Entity.
    J Maxillofac Oral Surg 2017 Sep 10;16(3):382-386. Epub 2016 Dec 10.
    Subharti Dental College, Swami Vivekanand Subharti University, NH - 58, Meerut, Uttar Pradesh 250005 India.
    Submandibular gland tumours, especially mesenchymal tumours, are extremely rare. Schwannoma of the salivary gland is a particularly rare form of an extracranial neurogenic tumor, of which ancient schwannoma is one of five variants. Since the first description, only a few ancient schwannomas have been reported in different locations in the head and neck region. Read More

    A Rare Report of Two Cases: Ancient Schwannoma of Infratemporal Fossa and Verocay Schwannoma of Buccal Mucosa.
    Ann Maxillofac Surg 2017 Jan-Jun;7(1):140-142
    Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Schwannoma is a benign tumor that originates from Schwann cells of the peripheral nerve. Occurring as a common tumor in the head and neck region, its intraoral presentation is rare which accounts for only 1%. They are solitary, slow-growing, smooth-surfaced, usually asymptomatic, and encapsulated tumor. Read More

    Surgical management of a large neurilemmoma-like leiomyoma of the uterine cervix mimicking a retroperitoneal tumor.
    Gynecol Oncol Rep 2017 Aug 24;21:53-56. Epub 2017 Jun 24.
    Department of Pathologic Oncology, National Cancer Institute of Colombia (INC), Street 1 # 9-85, Bogotá, Colombia.
    •A large cervical neurilemmoma-like leiomyoma can simulate a retroperitoneal tumor.•They are extremely rare tumors that require adequate bleeding control.•Comprehensive anatomo-pathological study should be done to rule out malignancy. Read More

    Ancient schwannoma of the cervical sympathetic chain.
    Clin Case Rep 2017 Jul 16;5(7):1077-1080. Epub 2017 May 16.
    Brighton & Sussex University Hospitals NHS Trust177 Preston RdBrightonBN1 6AGUK.
    Ancient schwannomas exhibit characteristic histological features. Fine-needle aspiration cytology (FNAC) is of limited use. Radiological evidence demonstrating displacement of blood vessels may aid diagnosis of schwannoma. Read More

    [Anterior skull-base schwannoma].
    Neurocirugia (Astur) 2017 Nov - Dec;28(6):298-305. Epub 2017 Jun 24.
    Departamento de Anatomía Patológica, Hospital México, Costa Rica; Programa de Investigación Neurocirugía y Órganos de los Sentidos (PINECOS), Universidad de Costa Rica, San José, Costa Rica.
    Schwannomas are nerve sheath tumours that originate in Schwann cells. They are usually solitary and sporadic and manifest on peripheral, spinal or cranial nerves. Intracranial schwannomas tend to manifest on the eighth cranial nerve, particularly in patients with neurofibromatosis type2. Read More

    [Application value of whole brain 3D artery spin labeling in diagnosis of intracranial tumors].
    Zhonghua Yi Xue Za Zhi 2017 Jun;97(23):1801-1804
    State Key Laboratory of Oncology in Southern China, Minimally Invasive and Interventional Department, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
    Objective: To investigate the perfusion characteristics of arterial spin labeling (ASL) in intracranial tumor and its application value in classification. Methods: The clinical, pathological and imaging data of 44 patients with gliomas confirmed by pathology were analyzed retrospectively, including 9 low grade gliomas, 15 high grade gliomas, 11 cases of meningiomas, 6 cases of neurilemmoma, 3 cases of metastatic tumors.Conventional plain scan, 3D- ASL and MRI dynamic enhanced imaging (DSC-MRI) were performed. Read More

    Management of Residual Tumor After Limited Subtotal Resection of Large Vestibular Schwannomas: Lessons Learned and Rationale for Specialized Care.
    World Neurosurg 2017 Sep 21;105:737-744. Epub 2017 Jun 21.
    Department of Neurologic Surgery, Mayo Clinic School of Medicine, Rochester, Minnesota, USA; Department of Otorhinolaryngology, Mayo Clinic School of Medicine, Rochester, Minnesota, USA. Electronic address:
    Background: In an era where subtotal resection (STR) is increasingly used, we have encountered a growing number of patients referred to our institution with limited resection of large vestibular schwannomas (VSs), sometimes associated with grave complications. Our aim was to highlight lessons learned in the management of large VSs and provide a rationale for specialized care.

    Methods: A prospectively maintained database of >2000 patients with VSs evaluated at our institution between 2000 and 2016 was reviewed. Read More

    Peripheral nerve sheath tumors of the breast.
    Semin Diagn Pathol 2017 Sep 27;34(5):420-426. Epub 2017 May 27.
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA; Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA. Electronic address:
    Benign and malignant peripheral nerve sheath tumors can involve the breast, presenting as masses in the dermis, deep breast parenchyma or axillary soft tissue. Although the histologic features are frequently characteristic, diagnosis can be challenging on core needle biopsy, and the differential diagnosis includes a variety of other benign and malignant spindle cell lesions of the breast. Here, we review the key clinical and pathological features of breast schwannoma, neurofibroma, granular cell tumor, and malignant peripheral nerve sheath tumor. Read More

    Giant Bicompartmental Cystic Tentorial Schwannoma Mimicking a Meningioma.
    World Neurosurg 2017 Sep 20;105:1038.e17-1038.e22. Epub 2017 Jun 20.
    Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
    Background: Intracranial schwannomas most commonly arise from the vestibulocochlear nerve and less frequently from trigeminal, facial, and hypoglossal nerves. Intracranial schwannomas unrelated to cranial nerves are very rare; only approximately 50 cases have been reported in the literature. Tentorial schwannoma (TS) is even rarer, with only 13 cases reported to date. Read More

    Role of endoscopic ultrasound and endoscopic resection for the treatment of gastric schwannoma.
    Medicine (Baltimore) 2017 Jun;96(25):e7175
    Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang, China.
    Endoscopic ultrasound (EUS) and endoscopic resection play an important role in gastric submucosal tumor. However, there were few articles regarding EUS and endoscopic resection of gastric schwannomas. Our aim was to evaluate the role of EUS and endoscopic resection in treating gastric schwannomas. Read More

    An Unusual Differential Diagnosis of Orbital Cavernous Hemangioma: Ancient Schwannoma.
    Case Rep Ophthalmol 2017 May-Aug;8(2):294-300. Epub 2017 May 8.
    Orbit and Oculoplastic Surgery Unit, Ophthalmology Department, Hospital Universitario Rámon y Cajal, IRYCIS, Oculoplastic Surgery Unit, Novovision, Madrid, Spain.
    Schwannomas are rare lesions of the orbit that can be confused with cavernous hemangioma on imaging studies. We report the case of an 84-year-old woman with a 9-year history of a tumoral lesion in the inferolateral left orbit. The imaging studies did not reveal specific characteristics, only bone remodeling due to the long evolution of the tumor. Read More

    Association of posterior semicircular canal hypofunction on video-head-impulse testing with other vestibulo-cochlear deficits.
    Clin Neurophysiol 2017 Aug 17;128(8):1532-1541. Epub 2017 May 17.
    Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland; Department of Ophthalmology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
    Objectives: The video-head-impulse test (vHIT) provides a functional assessment of all six semicircular canals (SCC). Occasionally isolated loss of the posterior canal(s) (ILPC) is diagnosed, though this finding is poorly characterized. Here we assessed how accurate that diagnosis is by measuring the co-occurrence of abnormalities on caloric irrigation, vestibular-evoked myogenic-potentials and audiometry. Read More

    Radiation-Induced Malignant Peripheral Nerve Sheath Tumors: A Systematic Review.
    World Neurosurg 2017 Sep 8;105:961-970.e8. Epub 2017 Jun 8.
    Laboratory of Molecular Target Therapy for Cancer, Graduate School for Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
    Objective: Radiation-induced malignant peripheral nerve sheath tumors (MPNSTs) are an uncommon late risk of irradiation. We conducted the largest systematic review to date of individual patient data for patients with these tumors.

    Methods: We conducted a systematic search using the PubMed database, and compiled a systematic literature review. Read More

    Spontaneous Regression of a Hypoglossal Neurinoma: Case Report and Review of the Literature.
    World Neurosurg 2017 Sep 8;105:1033.e7-1033.e9. Epub 2017 Jun 8.
    Department of Neurosurgery, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain.
    Background: Hypoglossal neurinomas are very rare intracranial tumors. The management choices include surgery, as the gold standard, and radiosurgery or a combination of both. Little is known about this condition and the behavior of this tumor. Read More

    Intraoral ancient schwannoma: A systematic review of the case reports.
    Dent Res J (Isfahan) 2017 Mar-Apr;14(2):87-96
    Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
    Intraoral ancient schwannoma is a rare type of oral schwannoma, which is encapsulated and well demarcated from the surrounding tissues. Ancient schwannomas are associated with conventional features of neurilemmoma; however, they are distinguished from other types of schwannoma due to factors such as the long history, cellular architecture showing hypocellularity, and hyalinized matrices. This systematic review was performed through searching in databases such as PubMed and Google Scholar using related keywords (intraoral, oral, ancient, schwannoma, and neurilemmoma). Read More

    The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals.
    Lab Invest 2017 Jul 5;97(7):843-853. Epub 2017 Jun 5.
    Department of Medicine, Texas A&M Health Science Center, College of Medicine, Temple, TX, USA.
    The Hippo signaling pathway and the Notch signaling pathway are evolutionary conserved signaling cascades that have important roles in embryonic development of many organs. In murine liver, disruption of either pathway impairs intrahepatic bile duct development. Recent studies suggested that the Notch signaling receptor Notch2 is a direct transcriptional target of the Hippo signaling pathway effector YAP, and the Notch signaling is a major mediator of the Hippo signaling in maintaining biliary cell characteristics in adult mice. Read More

    Large schwannoma of the femur - a common tumor at an unusual site: a case report and review of the literature.
    J Med Case Rep 2017 May 31;11(1):147. Epub 2017 May 31.
    Nawaloka Hospitals PLC, Colombo, Sri Lanka.
    Background: Schwannomas are benign nerve sheath tumors and are most frequently encountered as soft tissue tumors of peripheral nerves of the head and neck or the extensor extremities. Osseous involvement is very uncommon with fewer than 200 cases described in the world literature, the majority of which arise in the skull (including mandible), vertebrae, and sacrum. Long bone involvement is highly unusual and of the approximately 20 cases described thus far, only five have been documented to arise in the femur. Read More

    Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor.
    PLoS One 2017 30;12(5):e0178064. Epub 2017 May 30.
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Background: Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. Hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the cellular response to hypoxia and regulates the expression of multiple genes involved in tumor progression in various cancers. However, the importance of the expression of HIF-1α in MPNSTs is unclear. Read More

    Doxycycline potentiates antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy in malignant peripheral nerve sheath tumor cells.
    PLoS One 2017 30;12(5):e0178493. Epub 2017 May 30.
    Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.
    Neurofibromatosis type 1 (NF1) is one of the most common neurocutaneous disorders. Some NF1 patients develop benign large plexiform neurofibroma(s) at birth, which can then transform into a malignant peripheral nerve sheath tumor (MPNST). There is no curative treatment for this rapidly progressive and easily metastatic neurofibrosarcoma. Read More

    Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1-a consensus overview.
    Hum Pathol 2017 Sep 24;67:1-10. Epub 2017 May 24.
    Department of Pathology, Division of Neuropathology, University of California, San Francisco, CA 94143, USA.
    Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime. Prediction of transformation, typically from plexiform neurofibroma, is clinically and histologically challenging. In this overview, after a consensus meeting in October 2016, we outline the histopathologic features and molecular mechanisms involved in the malignant transformation of neurofibromas. Read More

    Elective Venovenous Extracorporeal Membrane Oxygenation for Resection of Endotracheal Tumor: A Case Report.
    A A Case Rep 2017 Aug;9(4):97-100
    From the *Department of Anesthesiology, †Department of Surgery, ‡Department of Internal Medicine, and ∥Perfusion Services, Duke University Medical Center, Durham, North Carolina; §Staten Island University Hospital / Northwell Health, Staten Island, New York; and ¶Vanderbilt University Medical Center, Nashville, Tennessee.
    We present a case in which we electively used venovenous extracorporeal membrane oxygenation (VV-ECMO) to facilitate safe resection of a nearly obstructing airway tumor near the carina in a 37-year-old male. The patient was brought to the operating room and underwent bifemoral cannulation for VV-ECMO under light sedation while maintaining spontaneous ventilation. After VV-ECMO was initiated, general anesthesia was induced, and the tumor was resected via rigid bronchoscopy. Read More

    Probabilistic Multiple-Bias Modeling Applied to the Canadian Data From the Interphone Study of Mobile Phone Use and Risk of Glioma, Meningioma, Acoustic Neuroma, and Parotid Gland Tumors.
    Am J Epidemiol 2017 Oct;186(7):885-893
    We undertook a re-analysis of the Canadian data from the 13-country case-control Interphone Study (2001-2004), in which researchers evaluated the associations of mobile phone use with the risks of brain, acoustic neuroma, and parotid gland tumors. In the main publication of the multinational Interphone Study, investigators concluded that biases and errors prevented a causal interpretation. We applied a probabilistic multiple-bias model to address possible biases simultaneously, using validation data from billing records and nonparticipant questionnaires as information on recall error and selective participation. Read More

    Radiation-Induced Schwannomas and Neurofibromas: A Systematic Review.
    World Neurosurg 2017 Aug 19;104:713-722. Epub 2017 May 19.
    Laboratory of Molecular Target Therapy for Cancer, Graduate School for Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Objective: Radiation-induced benign peripheral nerve sheath tumors are uncommon late complications of irradiation. We conducted the largest systematic review of individual patient data.

    Methods: We performed a systematic search of PubMed databases and compiled a comprehensive literature review. Read More

    Gamma Knife Radiosurgery for Vestibular Schwannomas and Quality of Life Evaluation.
    Stereotact Funct Neurosurg 2017 23;95(3):166-173. Epub 2017 May 23.
    Leksell Center for Radiosurgery and Brain Mapping, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
    Background: Further investigation is needed to look at the impact of vestibular schwannoma (VS) on the health-related quality of life (QOL) of participants who undergo Gamma Knife® radiosurgery (GKRS).

    Objectives: Investigators compared the QOL for VS participants to reported US population norms in order to evaluate disease burden and long-term QOL several years after GKRS.

    Methods: This cross-sectional study surveyed participants to assess hearing status, tinnitus, imbalance, vertigo, as well as the Short-Form 36-item Health Questionnaire (SF-36). Read More

    Voluminous laryngeal schwannoma excision with a mini-invasive external approach: a case report.
    Acta Otorhinolaryngol Ital 2017 Jun;37(3):242-244
    Department of Otolaryngology Head and Neck Surgery, San Raffaele Scientific Institute, Milan, Italy.
    Laryngeal schwannomas are extremely uncommon. We present a case of bulky supraglottic schwannoma with involvement of the preepiglottic and superior paraglottic spaces. Clinical findings, computed tomography and magnetic resonance images are presented. Read More

    Spectral Computed Tomography Imaging of Gastric Schwannoma and Gastric Stromal Tumor.
    J Comput Assist Tomogr 2017 May/Jun;41(3):417-421
    From the *The School of Nuclear Science and Technology, Lanzhou University; Departments of †Radiology and ‡Pathology, Lanzhou University Second Hospital; and §School of Stomatology, Lanzhou University, Lanzhou, China.
    Gastric schwannomas (GSs) and gastrointestinal stromal tumors (GSTs) are grossly similar submucosal neoplasms with different prognoses. We explored the value of spectral computed tomography (CT) to distinguish between them.

    Methods: Patients diagnosed with GS or GST at Lanzhou University Second Hospital, China, between May 2013 and June 2015 were included retrospectively. Read More

    The Cellular Retinoic Acid Binding Protein 2 Promotes Survival of Malignant Peripheral Nerve Sheath Tumor Cells.
    Am J Pathol 2017 Jul 11;187(7):1623-1632. Epub 2017 May 11.
    Institute of Neuropathology, University Hospital Münster, Münster, Germany; Institute of Pathology, Brandenburg Medical School, Brandenburg, Germany. Electronic address:
    Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive neoplasms that commonly occur in patients with neurofibromatosis type 1 (NF1). Effective chemotherapy is not available. To characterize a therapeutic target for treatment, we investigated the role of cellular retinoic acid binding protein 2 (CRABP2) in MPNST in vitro. Read More

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