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    Oddities Sporadic Neurofibroma of the Urinary Bladder. A Case Report.
    Urol Case Rep 2017 Sep 12;14:42-44. Epub 2017 Jul 12.
    Department of Urology, Bicêtre Hospital, Le Kremlin Bicêtre, France.
    Neurofibromas of the urinary bladder are an exceedingly rare entity and are considered mostly in conjunction with the disease of neurofibromatosis type 1. The fortuitous discovery of vesical plexiform neurofibromas without other stigmata of the disease is presented in a 57-year-old male patient. The course of his condition, modalities of investigation and a non-precedent treatment plan are demonstrated. Read More

    Schwannoma of the tongue: a case report with review of literature.
    Maxillofac Plast Reconstr Surg 2017 Dec 5;39(1):17. Epub 2017 Jul 5.
    Department of Oral and Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University, SeoWon-gu Chungdae-ro 1, Cheong-ju, 28644 South Korea.
    Background: Schwannomas (or neurilemmomas) of the tongue are benign, usually solitary, encapsulated masses derived from Schwann cells. Clinical evidence indicates that schwannoma is painless and slow growing. In general, schwannoma is treated by surgical excision. Read More

    [Evaluation of a new closure technique of large defects after endoscopic full-thickness resection].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Jul;20(7):775-781
    Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
    Objective: To investigate the security and efficacy of a new endoscopic closure method of large defects after endoscopic full-thickness resection (EFTR) double purse-string suture using two endoloops and metallic clips via single-channel endoscopy.

    Methods: Clinical data of 23 cases with submucosal tumors (SMT) who received endoscopic resection from June 2015 to July 2016 in our National Cancer Center were collected. For gastric and esophageal SMTs or the mucosa layer injured during submucosal tunneling endoscopic resection (STER), double purse-string suture was conducted after EFTR. Read More

    Giant Solitary Schwannoma of Submandibular Salivary Gland-A Rare Entity.
    J Maxillofac Oral Surg 2017 Sep 10;16(3):382-386. Epub 2016 Dec 10.
    Subharti Dental College, Swami Vivekanand Subharti University, NH - 58, Meerut, Uttar Pradesh 250005 India.
    Submandibular gland tumours, especially mesenchymal tumours, are extremely rare. Schwannoma of the salivary gland is a particularly rare form of an extracranial neurogenic tumor, of which ancient schwannoma is one of five variants. Since the first description, only a few ancient schwannomas have been reported in different locations in the head and neck region. Read More

    A Rare Report of Two Cases: Ancient Schwannoma of Infratemporal Fossa and Verocay Schwannoma of Buccal Mucosa.
    Ann Maxillofac Surg 2017 Jan-Jun;7(1):140-142
    Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Schwannoma is a benign tumor that originates from Schwann cells of the peripheral nerve. Occurring as a common tumor in the head and neck region, its intraoral presentation is rare which accounts for only 1%. They are solitary, slow-growing, smooth-surfaced, usually asymptomatic, and encapsulated tumor. Read More

    Surgical management of a large neurilemmoma-like leiomyoma of the uterine cervix mimicking a retroperitoneal tumor.
    Gynecol Oncol Rep 2017 Aug 24;21:53-56. Epub 2017 Jun 24.
    Department of Pathologic Oncology, National Cancer Institute of Colombia (INC), Street 1 # 9-85, Bogotá, Colombia.
    •A large cervical neurilemmoma-like leiomyoma can simulate a retroperitoneal tumor.•They are extremely rare tumors that require adequate bleeding control.•Comprehensive anatomo-pathological study should be done to rule out malignancy. Read More

    Ancient schwannoma of the cervical sympathetic chain.
    Clin Case Rep 2017 Jul 16;5(7):1077-1080. Epub 2017 May 16.
    Brighton & Sussex University Hospitals NHS Trust177 Preston RdBrightonBN1 6AGUK.
    Ancient schwannomas exhibit characteristic histological features. Fine-needle aspiration cytology (FNAC) is of limited use. Radiological evidence demonstrating displacement of blood vessels may aid diagnosis of schwannoma. Read More

    [Anterior skull-base schwannoma].
    Neurocirugia (Astur) 2017 Jun 24. Epub 2017 Jun 24.
    Departamento de Anatomía Patológica, Hospital México, Costa Rica; Programa de Investigación Neurocirugía y Órganos de los Sentidos (PINECOS), Universidad de Costa Rica, San José, Costa Rica.
    Schwannomas are nerve sheath tumours that originate in Schwann cells. They are usually solitary and sporadic and manifest on peripheral, spinal or cranial nerves. Intracranial schwannomas tend to manifest on the eighth cranial nerve, particularly in patients with neurofibromatosis type2. Read More

    [Application value of whole brain 3D artery spin labeling in diagnosis of intracranial tumors].
    Zhonghua Yi Xue Za Zhi 2017 Jun;97(23):1801-1804
    State Key Laboratory of Oncology in Southern China, Minimally Invasive and Interventional Department, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
    Objective: To investigate the perfusion characteristics of arterial spin labeling (ASL) in intracranial tumor and its application value in classification. Methods: The clinical, pathological and imaging data of 44 patients with gliomas confirmed by pathology were analyzed retrospectively, including 9 low grade gliomas, 15 high grade gliomas, 11 cases of meningiomas, 6 cases of neurilemmoma, 3 cases of metastatic tumors.Conventional plain scan, 3D- ASL and MRI dynamic enhanced imaging (DSC-MRI) were performed. Read More

    Role of endoscopic ultrasound and endoscopic resection for the treatment of gastric schwannoma.
    Medicine (Baltimore) 2017 Jun;96(25):e7175
    Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang, China.
    Endoscopic ultrasound (EUS) and endoscopic resection play an important role in gastric submucosal tumor. However, there were few articles regarding EUS and endoscopic resection of gastric schwannomas. Our aim was to evaluate the role of EUS and endoscopic resection in treating gastric schwannomas. Read More

    An Unusual Differential Diagnosis of Orbital Cavernous Hemangioma: Ancient Schwannoma.
    Case Rep Ophthalmol 2017 May-Aug;8(2):294-300. Epub 2017 May 8.
    Orbit and Oculoplastic Surgery Unit, Ophthalmology Department, Hospital Universitario Rámon y Cajal, IRYCIS, Oculoplastic Surgery Unit, Novovision, Madrid, Spain.
    Schwannomas are rare lesions of the orbit that can be confused with cavernous hemangioma on imaging studies. We report the case of an 84-year-old woman with a 9-year history of a tumoral lesion in the inferolateral left orbit. The imaging studies did not reveal specific characteristics, only bone remodeling due to the long evolution of the tumor. Read More

    Intraoral ancient schwannoma: A systematic review of the case reports.
    Dent Res J (Isfahan) 2017 Mar-Apr;14(2):87-96
    Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
    Intraoral ancient schwannoma is a rare type of oral schwannoma, which is encapsulated and well demarcated from the surrounding tissues. Ancient schwannomas are associated with conventional features of neurilemmoma; however, they are distinguished from other types of schwannoma due to factors such as the long history, cellular architecture showing hypocellularity, and hyalinized matrices. This systematic review was performed through searching in databases such as PubMed and Google Scholar using related keywords (intraoral, oral, ancient, schwannoma, and neurilemmoma). Read More

    Large schwannoma of the femur - a common tumor at an unusual site: a case report and review of the literature.
    J Med Case Rep 2017 May 31;11(1):147. Epub 2017 May 31.
    Nawaloka Hospitals PLC, Colombo, Sri Lanka.
    Background: Schwannomas are benign nerve sheath tumors and are most frequently encountered as soft tissue tumors of peripheral nerves of the head and neck or the extensor extremities. Osseous involvement is very uncommon with fewer than 200 cases described in the world literature, the majority of which arise in the skull (including mandible), vertebrae, and sacrum. Long bone involvement is highly unusual and of the approximately 20 cases described thus far, only five have been documented to arise in the femur. Read More

    Voluminous laryngeal schwannoma excision with a mini-invasive external approach: a case report.
    Acta Otorhinolaryngol Ital 2017 Jun;37(3):242-244
    Department of Otolaryngology Head and Neck Surgery, San Raffaele Scientific Institute, Milan, Italy.
    Laryngeal schwannomas are extremely uncommon. We present a case of bulky supraglottic schwannoma with involvement of the preepiglottic and superior paraglottic spaces. Clinical findings, computed tomography and magnetic resonance images are presented. Read More

    Spectral Computed Tomography Imaging of Gastric Schwannoma and Gastric Stromal Tumor.
    J Comput Assist Tomogr 2017 May/Jun;41(3):417-421
    From the *The School of Nuclear Science and Technology, Lanzhou University; Departments of †Radiology and ‡Pathology, Lanzhou University Second Hospital; and §School of Stomatology, Lanzhou University, Lanzhou, China.
    Gastric schwannomas (GSs) and gastrointestinal stromal tumors (GSTs) are grossly similar submucosal neoplasms with different prognoses. We explored the value of spectral computed tomography (CT) to distinguish between them.

    Methods: Patients diagnosed with GS or GST at Lanzhou University Second Hospital, China, between May 2013 and June 2015 were included retrospectively. Read More

    Intraoral neurilemmoma of mental nerve mimicking as traumatic fibroma: An unusual presentation - A case report and literature review.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):124-128
    Department of Oral and Maxillofacial Pathology, Faculty of Dental Sciences, Sri Ramachandra Medical Centre, Chennai, Tamil Nadu, India.
    Neurilemmoma, neurinoma or schwannoma is a benign tumor of neurogenic origin, arising from the myelin sheath of a neuron. Head and neck region accounts for 25%-48% of these tumors reported till date. On the contrary, intraoral sites form only 1% of the cases accounted. Read More

    Small palatal swelling: an uncommon presentation of intraoral schwannoma.
    Gen Dent 2017 May-Jun;65(3):58-61
    Schwannomas are uncommon benign tumors arising in the nerve-supporting Schwann cells. Intraoral lesions usually present in the tongue or floor of the mouth as a submucosal nodule, while the palate is rarely affected. A 26-year-old white man presented with an asymptomatic submucosal fibroelastic nodule in the hard palate. Read More

    TIM-3 plays a more important role than PD-1 in the functional impairments of cytotoxic T cells of malignant Schwannomas.
    Tumour Biol 2017 May;39(5):1010428317698352
    Department of Neurosurgery, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, china.
    Cancer immunotherapy using cytotoxic T cells demonstrates dramatic survival benefits in lymphomas, but its efficacy in solid tumors is limited. Here, we investigated the possibility of using cytotoxic T cells to treat malignant Schwannoma, a rare but aggressive nerve sheath tumor, by examining the native T-cell immunity in the host. We found that compared to CD8(+) T cells from healthy controls or benign Schwannoma patients, the CD8(+) T cells from malignant Schwannoma patients were present at normal frequencies but were substantially enriched with PD-1(-)TIM-3(+) and PD-1(+)TIM-3(+) cells. Read More

    Hypoxia-induced miR-210 promoter demethylation enhances proliferation, autophagy and angiogenesis of schwannoma cells.
    Oncol Rep 2017 May 16;37(5):3010-3018. Epub 2017 Mar 16.
    Department of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
    Hypoxia, a dominant feature in cancer occurrence and evolution, exists throughout the progression of most malignant tumors. This study focused on the mechanism of hypoxia-induced miR-210 upregulation, and the miR-210 functions in schwannoma. We detected microvascular density, vascular endothelial growth factor (VEGF) and miR-210 expression levels using schwannoma tissue mciroarray. Read More

    Generation of a human induced pluripotent stem cell (iPSC) line from a 64year old male patient with multiple schwannoma.
    Stem Cell Res 2017 Mar 21;19:49-51. Epub 2016 Dec 21.
    Department of Ophthalmology, The 2nd Hospital of Jilin University, Changchun 130041, China.
    Peripheral blood was collected from a clinically diagnosed 64-year old male multiple schwannoma patient. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pluripotency markers, and the iPSC line was able to differentiate into the 3 germ layers in vivo. Read More

    Development of human induced pluripotent stem cell (iPSC) line from a 60year old female patient with multiple schwannoma.
    Stem Cell Res 2017 Mar 23;19:31-33. Epub 2016 Dec 23.
    Department of Ophthalmology, The 2nd Hospital of Jilin University, Changchun 130041, China.
    Peripheral blood was collected from a clinically diagnosed 60-year old female patient with multiple schwannoma. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pluripotency markers, and the iPSC line was able to differentiate into the 3 germ layers in vivo. Read More

    Giant Schwannoma of ulnar nerve: case report.
    Rev Bras Ortop 2017 Mar-Apr;52(2):224-227. Epub 2016 Sep 20.
    Centro Hospitalar São João, Porto, Portugal.
    Schwannomas are the most common benign neoplasms of the peripheral nerves in the upper limbs. Although many are asymptomatic, they can produce a mass effect, thus impinging against soft tissues or interfering with joint function. The authors present a case report and a review of a giant Schwannoma in the ulnar nerve. Read More

    Acta Clin Croat 2016 Jun;55(2):331-3
    Schwannomas are benign encapsulated tumors arising from the sheaths of peripheral nerves. They present as slowly enlarging solitary lumps, which may cause neurological defects. Multiple schwannomas in non-neurofi bromatosis type 2 patients are extremely rare. Read More

    The radiosurgery fractionation quandary: single fraction or hypofractionation?
    Neuro Oncol 2017 04;19(suppl_2):ii38-ii49
    Mayo Clinic, Rochester, Minnesota, MN, USA.
    Stereotactic radiosurgery (SRS), typically administered in a single session, is widely employed to safely, efficiently, and effectively treat small intracranial lesions. However, for large lesions or those in close proximity to critical structures, it can be difficult to obtain an acceptable balance of tumor control while avoiding damage to normal tissue when single-fraction SRS is utilized. Treating a lesion in 2 to 5 fractions of SRS (termed "hypofractionated SRS" [HF-SRS]) potentially provides the ability to treat a lesion with a total dose of radiation that provides both adequate tumor control and acceptable toxicity. Read More

    Immunohistochemical Approach to the Differential Diagnosis of Meningiomas and Their Mimics.
    J Neuropathol Exp Neurol 2017 04;76(4):289-298
    Pathology Department, Academic Hospital and Medicine University, INSERM U954, Université de Lorraine, Nancy, France
    The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA), progesterone receptor, somatostatin receptor 2A (SSTR2A), CD34, STAT6, S100, SOX10, HMB45, MelanA, GFAP, inhibin, and BCL2 antibodies. Read More

    Approaches to paraspinal tumours - a technical note.
    Neurol Res 2017 Apr 23;39(4):315-322. Epub 2017 Mar 23.
    a Lilavati Hospital and Research Centre , Mumbai , India.
    Neurogenic tumours of the paraspinal space can occur in all age groups. It is common in adult population and relatively rare in elderly group. Usually they are benign, but in children, arising from the autonomic system, tends to be malignant in nature. Read More

    Ultrasound assessment of peripheral nerve pathology in neurofibromatosis type 1 and 2.
    Clin Neurophysiol 2017 May 20;128(5):702-706. Epub 2017 Feb 20.
    Center of Neurology, Tübingen University Hospital and Hertie Institute for Clinical Brain Research, Eberhard-Karl University Tübingen, Tübingen, Germany. Electronic address:
    Objective: The neurofibromatoses (NF) type 1 and 2 are hereditary tumor predisposition syndromes caused by germline mutations in the NF1 and NF2 tumor suppressor genes. In NF1 and 2, peripheral nerve tumors occur regularly. For further characterizing nerve ultrasound was performed in patients with NF1 and 2. Read More

    A rare thoracic intraspinal schwannoma in twin pregnancy with aggravated clinical presence: A case report following CARE.
    Medicine (Baltimore) 2017 Mar;96(11):e6327
    aDepartment of Neurosurgery, West China Hospital bDepartment of Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
    Introduction: This is the first case report about a thoracic intraspinal schwannoma in twin pregnancy with aggressive clinical presentation.

    Clinical Presence And Diagnoses: A 21-year-old woman presented with a 2-month history of back pain and slight lower extremity numbness and weakness, and her symptoms were misdiagnosed as normal reactions to pregnancy until she progressed to complete paralysis and incontinence within 2 weeks. She was then confirmed to have thoracic intraspinal schwannoma through MRI. Read More

    [Intramedullary spinal cord tumors and neurofibromatosis].
    Zh Vopr Neirokhir Im N N Burdenko 2017;81(1):70-73
    Burdenko Neurosurgical Institute, Moscow, Russia.
    The article addresses the issue of a combination and relationship between intramedullary spinal cord tumors (IMSCTs) and neurofibromatosis (NF).

    Aim: To study, based on large clinical material, features of the prevalence and biological nature of intramedullary spinal cord tumors in neurofibromatosis patients in different age groups.

    Material And Methods: We analyzed the data of the largest series of patients from all age groups who underwent surgery for spinal cord intramedullary tumors (541 patients; 586 surgeries; age, 2 months to 72 years). Read More

    Laparoscopic resection of retroperitoneal benign neurilemmoma.
    Ann Surg Treat Res 2017 Mar 24;92(3):149-155. Epub 2017 Feb 24.
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.; Pancreaticobiliary Cancer Clinic, Yonsei Cancer Center, Institute of Gastroenterology Severance Hospital, Seoul, Korea.
    Purpose: The aim of this study was to verify that laparoscopic resection for treating retroperitoneal benign neurilemmoma (NL) is expected to be favorable for complete resection of tumor with technical feasibility and safety.

    Methods: We retrospectively analyzed 47 operations for retroperitoneal neurogenic tumor at Yonsei University College of Medicine, Severance Hospital and Gangnam Severance Hospital between January 2005 and September 2015. After excluding 21 patients, the remaining 26 were divided into 2 groups: those who underwent open surgery (OS) and those who underwent laparoscopic surgery (LS). Read More

    Intraconal optic sheath schwannoma: report of two cases.
    Br J Neurosurg 2017 Mar 10:1-3. Epub 2017 Mar 10.
    c Department of Pathology , Bombay Hospital Institute of Medical Sciences & Research Centre , Mumbai , India.
    Optic sheath schwannoma is extremely rare. We discuss two cases of intraorbital intraconal optic sheath schwannoma. Vision significantly improved in both patients following the surgery. Read More

    Acoustic schwannoma with intracochlear extension and primary intracochlear schwannoma: removal through translabyrinthine approach with facial bridge cochleostomy and transcanal approach.
    Eur Arch Otorhinolaryngol 2017 May 27;274(5):2149-2154. Epub 2017 Feb 27.
    Department of Neuroscience, Otolaryngology Unit, Padova University, via Giustiniani 2, 35128, Padova, Italy.
    Intracochlear schwannomas can occur either as an extension of a larger tumor from the internal auditory canal, or as a solitary labyrinthine tumor. They are currently removed via a translabyrinthine approach extended to the basal turn, adding a transotic approach for tumors lying beyond the basal turn. Facial bridge cochleostomy may be associated with the translabyrinthine approach to enable the whole cochlea to be approached without sacrificing the external auditory canal and tympanum. Read More

    Peripheral Nerve Schwannoma: A Review of Varying Clinical Presentations and Imaging Findings.
    J Foot Ankle Surg 2017 May - Jun;56(3):632-637. Epub 2017 Feb 22.
    Physician, Medical Arts Radiology, Commack, NY.
    A schwannoma or neurilemmoma is a benign, isolated, noninvasive, and encapsulated tumor originating from Schwann cells of the peripheral nerve sheath. The incidence of a schwannoma occurring in the foot and ankle is rare, with prevalence rate of 1% to 10%. Schwannomas have no sex predilection, and they commonly occur in patients in their fourth decade. Read More

    Colonic Schwannoma: A Case Study and Literature Review of a Rare Entity and Diagnostic Dilemma.
    Am Surg 2016 Dec;82(12):1183-1186
    Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
    An asymptomatic 73-year-old woman was found to have a submucosal mass in the descending colon on routine colonoscopy. A CT scan revealed a 31 × 28 × 31 mm lesion in the same location. Previous biopsy proved to be nondiagnostic, and the patient underwent a laparoscopic descending colon resection. Read More

    Solid-Cystic Hypoglossal Nerve Schwannoma with Fluid-Fluid Level: A Rare Case Report.
    J Clin Diagn Res 2016 Dec 1;10(12):TD06-TD08. Epub 2016 Dec 1.
    Resident, Department of Radiology, Krishna Hospital and Medical Research Center , Karad, Maharashtra, India .
    Schwannomas (neurinoma, neurilemmoma) are benign slow-growing encapsulated tumours originating from well-differentiated myelin-producing Schwann cells or nerve fiber sheet cells at the glial-Schwann cell junction. Hypoglossal nerve schwannoma mostly develops in the intracranial and extra-cranial segment or in both intracranial and extra-cranial segment forming a dumbbell shape tumour. The peripheral hypoglossal schwannomas are very rare. Read More

    Schwannoma of the tongue-A common tumour in a rare location: A case report.
    Eur J Radiol Open 2017 1;4:1-3. Epub 2017 Feb 1.
    Serviço de Imagem Médica - Centro Hospitalar Universitário de Coimbra, Praceta Mota Pinto, 3000-075 Coimbra, Portugal.
    Schwannoma is a benign tumour that arises from Schwann cells of the peripheral nerve sheath, and is a common tumour of the head and neck. However, intraoral location is very uncommon (only 1% of all head and neck schwannomas). We report a rare case of lingual schwannoma in a 20-year-old male patient who presented with a small, slow-growing mass over the right lateral border of the tongue with 1 year of evolution and that became recently ulcerated. Read More

    A non-surgical approach to the management of exposure keratitis due to facial palsy by using mini-scleral lenses.
    Medicine (Baltimore) 2017 Feb;96(6):e6020
    Lexington Eye Associates, Westford, MA.
    Rationale: This is a retrospective study aimed to determine the efficacy of mini-scleral contact lens in protecting the cornea and improving vision in cases of facial palsy.

    Patient Concerns: Patients with facial palsy get exposure keratitis because the cornea is dry. They feel pain, discomfort and excessive watering. Read More

    Lateral skull base surgery in a pediatric population: A 25-year experience in a referral skull base center.
    Int J Pediatr Otorhinolaryngol 2017 Mar 14;94:70-75. Epub 2017 Jan 14.
    Department of Otology & Skull Base Surgery, Gruppo Otologico, Piacenza, Rome, Italy.
    Objective: To analyze the pathology and surgical outcomes of lateral skull base (LSB) procedures in a pediatric population.

    Study Design: Retrospective case review in a referral skull base center.

    Methods: Charts of pediatric patients who underwent defined LSB procedures from 1983 to 2015 for various pathologies were evaluated at our center. Read More

    Inter-observer variability between radiologists reporting on cerebellopontine angle tumours on magnetic resonance imaging.
    J Laryngol Otol 2017 Jan;131(S1):S47-S49
    Department of Otolaryngology,St Vincent's Private Hospital,Sydney,Australia.
    Background: Studies demonstrate the significance of intra- and inter-observer variability when measuring cerebellopontine angle tumours on magnetic resonance imaging, with measured differences as high as 2 mm.

    Objective: To determine intra- and inter-observer measurement variability of cerebellopontine angle tumours in a specialised institution.

    Methods: The magnetic resonance imaging maximal diameter of 12 randomly selected cerebellopontine angle tumours were independently measured by 4 neuroradiologists at a tertiary referral centre using a standard definition for maximal tumour diameter. Read More

    Patients with benign hand tumors are indicated for surgery according to patient-rated outcome measures.
    J Plast Reconstr Aesthet Surg 2017 Apr 9;70(4):487-494. Epub 2017 Jan 9.
    Department of Hand Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
    Introduction: This study assessed the treatment outcomes of upper extremity benign tumors using the patient-rated outcome measures of Hand20 questionnaire.

    Methods: In total, 304 patients who underwent surgery for benign bone and soft tissue tumors of the upper limb were included. Tumors were classified into three size groups: <1 cm, 1-3 cm, and >3 cm. Read More

    Peripheral Nerve Sheath Tumor.
    J Orthop Sports Phys Ther 2017 Feb;47(2):124
    A 26-year-old female military officer directly accessed physical therapy, relating a 4-month history of deep, intermittent left medial knee pain with running. Following physical therapy treatment, she was referred to her primary care manager. Magnetic resonance imaging of the knee was ordered, revealing a peripheral nerve sheath tumor with benign features within the distal gracilis attached to the saphenous nerve. Read More

    Benign Peripheral Nerve Sheath Tumor in a Distance Runner.
    J Orthop Sports Phys Ther 2017 Feb;47(2):125
    A 31-year-old female runner presented to physical therapy via direct access with an 8-month history of atraumatic left lateral calf pain. Following 1 month of physical therapy, the patient was referred to an orthopaedic sports medicine physician. Ultrasound imaging revealed a 2-cm hypoechoic mass with well-defined margins in the left proximal lateral soleus, while Doppler ultrasound demonstrated increased color flow surrounding the mass. Read More

    [A giant hyperostotic parasagittal meningioma in a child with neurofibromatosis type II (a case report and literature review)].
    Zh Vopr Neirokhir Im N N Burdenko 2016;80(6):66-73
    Burdenko Neurosurgical Institute, Moscow, Russia.
    Large parasagittal meningiomas, in particular hyperostotic ones, in children are rare and problematic in the differential diagnosis. The literature reports only single clinical cases related to this issue; opinions about the indications, surgical treatment options, and prognosis are contradictory. This paper presents a clinical case of a hyperostotic parasagittal meningioma with intra-extracranial growth in a 10-year-old boy with neurofibromatosis type II significantly worsening the prognosis. Read More

    Functional outcome and complications after the microsurgical removal of giant vestibular schwannomas via the retrosigmoid approach: a retrospective review of 16-year experience in a single hospital.
    BMC Neurol 2017 Jan 31;17(1):18. Epub 2017 Jan 31.
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.
    Background: Intracranial vestibular schwannoma still remain to be difficulty for its unique microsurgical technique and preservation of neuro-function, as well as reducing common complications that may arise in surgery.

    Methods: We consecutively enrolled 657 unilateral giant (>4 cm diameter) vestibular schwannoma patients treated in Huashan Hospital via the suboccipital retrosigmoid approach in the past 16 years. The extension of tumor removal, surgical mortality, facial nerve function, hearing, and the other main short and long-term complications were the studied parameters. Read More

    Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target.
    EBioMedicine 2017 Feb 18;16:76-86. Epub 2017 Jan 18.
    Institute of Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, John Bull Building, Plymouth Science Park, Research Way, Derriford, Plymouth PL6 8BU, UK. Electronic address:
    Loss or mutation of the tumour suppressor Merlin predisposes individuals to develop multiple nervous system tumours, including schwannomas and meningiomas, sporadically or as part of the autosomal dominant inherited condition Neurofibromatosis 2 (NF2). These tumours display largely low grade features but their presence can lead to significant morbidity. Surgery and radiotherapy remain the only treatment options despite years of research, therefore an effective therapeutic is required. Read More

    Comparison between MR imaging findings of intracranial and extracranial schwannomas.
    Clin Imaging 2017 Mar - Apr;42:218-223. Epub 2017 Jan 16.
    Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
    Purpose: To evaluate the differences of MR imaging findings between intracranial and extracranial schwannomas.

    Methods: We retrospectively reviewed the MR images of 98 schwannomas and compared the imaging findings between intracranial and extracranial schwannomas.

    Results: The number of intratumoral cysts was greater in intracranial than in extracranial schwannomas (4. Read More

    Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review.
    Diagn Pathol 2017 Jan 19;12(1):11. Epub 2017 Jan 19.
    Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
    Background: Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicopathological characteristics of epithelioid schwannoma.

    Case Presentation: A 65-year-old female presented with a history of a flat and slightly elevated firm and tan plaque accompanied by occasional tenderness, measuring 10 × 8 mm, in the right joint of her hand 1 year before resection. Read More

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