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BMC Surg 2022 May 10;22(1):159. Epub 2022 May 10.

General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China, 310014.

Background: This study aimed to investigate the clinical features, diagnostic criteria, treatment options, and prognosis of patients with gastric schwannoma (GS).

Methods: We collected the clinical data of all patients pathologically diagnosed with GS in Zhejiang Provincial People's Hospital from May 2012 to October 2021.

Results: A total of 26 cases of GS were analyzed clinicopathologically, where the sizes of the tumor were found to be in the range of 1-6 cm (mean: 3. Read More

Neurosurg Focus 2022 05;52(5):E5

1Department of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.

Objective: The objective of this paper was to describe the volumetric natural history of meningiomas in patients with neurofibromatosis type 2 (NF2).

Methods: The authors performed a retrospective descriptive study by reviewing NF2 patients with meningiomas at their institution between 2000 and 2019. Demographic data were collected from the electronic medical records. Read More

Neurol India 2022 Mar-Apr;70(2):784-787

Department of Otorhinolaryngology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Nasoethmoidal schwannomas are rare lesions and their presentation with intracranial extension is even rarer. Here, a patient presenting with rhinorrhea, epistaxis, and proptosis of left eye was diagnosed with giant nasoethmoidal schwannoma extending to frontal lobe and orbit, which was managed with bifrontal craniotomy with endoscopic transnasal gross total excision. This being predominantly a benign lesion has good prognosis if total excision is achieved. Read More

Neurol India 2022 Mar-Apr;70(2):563-573

Department of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: The challenges associated with surgeries of cavernous sinus (CS) lesions have shifted the management trend towards upfront gamma knife radiosurgery (GKRS). Although GKRS is effective in arresting the progression of certain small residual/recurrent lesions, its efficacy in alleviating neurological deficits is less evident. Furthermore, GKRS without establishing the histopathological diagnosis, at times can be detrimental. Read More

Biomed Res Int 2022 29;2022:8512374. Epub 2022 Apr 29.

Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

Background: The objective of this study was to evaluate the clinical effectiveness and safety of laminectomy combined with lateral mass screw fixation in treating cervical intradural extramedullary schwannoma.

Methods: We retrospectively collected and analyzed medical records of 38 patients who underwent resection of cervical intraspinal schwannoma between January 2012 and April 2019. Based on different surgical procedures, two groups were divided among all participants: laminectomy-only ( = 21) and laminectomy with instrumented fixation ( = 17); the minimum follow-up time was 1 year. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Apr;57(4):503-504

Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding hospital, Yantai 264000, China.

Radiat Oncol 2022 May 7;17(1):89. Epub 2022 May 7.

Department of Neurosurgery, Brain Research Institute, Yonsei Medical Gamma Knife Center, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Recently, stereotacitc radiosurgery (SRS) has been in the spotlight as an alternative therapeutic option for jugular foramen schwannomas (JFS). While most reported studies focus on the long-term efficacy and safety issues of SRS, none describe the early-onset adverse events (eAEs). We aimed to investigate the incidence, clinical characteristics, and mid-term outcomes of eAEs occurring within six months after SRS for JFS. Read More

PLoS One 2022 4;17(5):e0267931. Epub 2022 May 4.

Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia.

Background: Predicting reduced health-related quality of life (HRQoL) after resection of a benign or low-grade brain tumour provides the opportunity for early intervention, and targeted expenditure of scarce supportive care resources. We aimed to develop, and evaluate the performance of, machine learning (ML) algorithms to predict HRQoL outcomes in this patient group.

Methods: Using a large prospective dataset of HRQoL outcomes in patients surgically treated for low grade glioma, acoustic neuroma and meningioma, we investigated the capability of ML to predict a) HRQoL-impacting symptoms persisting between 12 and 60 months from tumour resection and b) a decline in global HRQoL by more than the minimum clinically important difference below a normative population mean within 12 and 60 months after resection. Read More

Ulus Travma Acil Cerrahi Derg 2022 Mar;28(3):399-401

Department of Thoracic Surgery, Afyonkarahisar State Hospital, Afyonkarahisar-Turkey.

A case of hemothorax caused by traumatic rupture of schwannoma is rarely reported. We present a case of thorax injury of an 18-year-old woman who had fallen from a high place with a Glasgow Coma Score 13. Chest X-ray showed a left-sided massive pleural effusion. Read More

Pol Przegl Chir 2021 Dec;94(2):49-53

Department of General and Hand Surgery, Pomeranian Medical University in Szczecin, Poland.

<b>Introduction:</b> Schwannoma is a nerve tumor originating from Schwann-cells of the nerve sheath. It is found in all body regions, the most frequent in the head, neck and in the extremities. </br></br> <b>Aim:</b> The objective of this study was analysis of outcomes of surgery for these lesions in the authors' institution. Read More

Malays J Pathol 2022 Apr;44(1):115-120

Universiti Sains Malaysia, School of Medical Sciences, Department of Pathology, Health Campus, Malaysia.

Introduction: Malignant peripheral nerve sheath tumour (MPNST) is an uncommon malignant neoplasm of childhood with unfavourable prognosis. Only a limited number of cases have been reported in children less than 12 years of age, and approximately one-half arise from a benign peripheral nerve sheath tumour, especially in the background of neurofibromatosis type 1 (NF1). Primary MPNST in children is even rarer. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 May;36(5):352-356

Department of Otolaryngology Head and Neck Surgery，Tianjin Huanhu Hospital，Tianjin，300350，China.

To investigate the surgical approach of transnasal endoscopic resection of benign lesions in the paramedian lateral skull base. Retrospectively analyze 40 cases of the clinical data of patients with benign lesions of the skull base from August 2018 to February 2021 with transnasal endoscopic surgery, including 9 cases of cholesteatoma, 6 cases of hemangioma, 1 case of hemangiopericytoma, 6 cases of schwannoma, 15 cases of sphenoid sinus lateral crypt meningocele and cerebrospinal fluid leak, 3 cases of nasopharyngeal carcinoma bone inflammation after radiotherapy. All patients underwent transnasal endoscopic surgery, and different surgical approaches were selected according to the lesion location. Read More

Pathologica 2022 Apr;114(2):159-163

Unit of Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Microcystic/reticular (MRV) schwannoma has been described since 2008, but remains a rarely encountered entity. MRV has a predilection for visceral locations and has variable histologic appareances. Given its rarity and anatomic variability, this entity could raise differential diagnostic issues with other tumours and malignancies. Read More

Medicine (Baltimore) 2022 Mar 11;101(10):e29006. Epub 2022 Mar 11.

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.

Rationale: Neurilemmoma is a benign tumor derived from the Schwann cells of the nerve sheath. The highest incidence of neurilemmoma occurs in the head and neck region; however, the nose and paranasal sinuses are rarely involved. Less than 4% of these tumors involve the nasal cavity and paranasal sinuses. Read More

J Hand Surg Asian Pac Vol 2022 Apr 19;27(2):366-369. Epub 2022 Apr 19.

Department of Plastic and Reconstructive Surgery, University Hospital Brussels (VUB), Brussels, Belgium.

Schwannomas of the ulnar nerve in the hand are uncommon and those arising from the deep motor branch of the ulnar nerve (DMBUN) are rare. We were able to find only five reports of a schwannoma of the DMBUN. We report a schwannoma arising from DMBUN beyond the Guyon canal and summarise the literature on schwannomas involving the DMBUN. Read More

Clin Case Rep 2022 Apr 15;10(4):e05726. Epub 2022 Apr 15.

Departement of general surgery Internal Security Forces Hospital Marsa Tunisia.

Schwannoma is a type of nerve tumor of the nerve sheath. They are preferentially localized on the head, neck, and flexor surfaces of the extremities. Retroperitoneal schwannoma is extremely rare. Read More

World J Clin Cases 2022 Mar;10(9):2883-2894

Department of Spine Surgery, The 940 Hospital of Joint Logistics Support force of Chinese People's Liberation, Lanzhou 730050, Gansu Province, China.

Background: Disc herniation refers to the displacement of disc material beyond its anatomical space. Disc sequestration is defined as migration of the herniated disc fragment into the epidural space, completely separating it from the parent disc. The fragment can move in upward, inferior, and lateral directions, which often causes low back pain and discomfort, abnormal sensation, and movement of lower limbs. Read More

BMJ Case Rep 2022 Apr 12;15(4). Epub 2022 Apr 12.

Orofacial Pain Clinic, Department of Oral Medicine and Oral Surgery, Hopital Bretonneau, AP-HP, Paris, France

A woman in her late 80s with severe bronchomalacia was referred to a tertiary orofacial pain clinic for unexplained right unilateral glossodynia of progressive and continuous evolution for the past 8 months, spreading to the ipsilateral labiomental region, associated with ipsilateral hypoacusia. Local and general clinical examinations were unremarkable and routine blood work could not reveal any underlying systemic disease explaining the glossodynia and burning/pricking labiomental pain. Suspecting a painful trigeminal neuropathy secondary to a space-occupying lesion, a cerebral MRI was prescribed, revealing an ipsilateral cerebellopontine angle lesion, compatible with either a schwannoma or meningioma. Read More

Zh Vopr Neirokhir Im N N Burdenko 2022 ;86(2):55-63

Burdenko Neurosurgical Center, Moscow, Russia.

Stereotactic radiosurgery of vestibular schwannoma is an effective and safe method of treatment. The phenomenon of schwannoma pseudo-progression (transient post-radiation enlargement) complicates assessment of the outcomes after radiosurgery.

Objective: To investigate the changes of vestibular schwannoma in different periods after radiosurgery. Read More

Zh Vopr Neirokhir Im N N Burdenko 2022 ;86(2):5-14

Burdenko Neurosurgical Center, Moscow, Russia.

Objective: To evaluate the efficacy and safety of minimally invasive «burr hole» microsurgery for vestibular schwannoma.

Material And Methods: A retrospective analysis of postoperative outcomes in 50 consecutive patients with vestibular schwannoma was performed. All patients underwent burr hole microsurgery between 2016 and 2020. Read More

BMJ Case Rep 2022 Apr 11;15(4). Epub 2022 Apr 11.

University of Virginia, Charlottesville, Virginia, USA

Hypoglossal schwannomas (HS) are extremely rare neoplasms. Surgical resection has historically been the treatment of choice but carries a significant risk of postoperative neurological deficits and mortality. Stereotactic radiosurgery (SRS) is a minimally invasive approach that may afford long-term tumour growth. Read More

Eur Arch Otorhinolaryngol 2022 Jun 7;279(6):3225-3226. Epub 2022 Apr 7.

Department of Otorhinolaryngology/Head and Neck Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Front Oncol 2022 15;12:768635. Epub 2022 Mar 15.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: To describe the outcome of intraocular tumor resection by partial transscleral sclerouvectomy (PTSU) combined with micro-invasive vitrectomy and reconstruction of the eyeball (MVRE) in Asian patients.

Design Methods And Participants: This retrospective, interventional cohort study included 366 patients who underwent PTSU combined with MVRE for intraocular tumors both in adult and pediatric age groups. The medical records of these patients were reviewed for clinical, operative, and histopathological features. Read More

Neurosurg Focus 2022 04;52(4):E8

1Department of Neurosurgery, Baylor College of Medicine.

Objective: Vestibular schwannomas (VSs) are the most common neoplasm of the cerebellopontine angle in adults. Though these lesions are generally slow growing, their growth patterns and associated symptoms can be unpredictable, which may complicate the decision to pursue conservative management versus active intervention. Additionally, surgical decision-making can be controversial because of limited high-quality evidence and multiple quality-of-life considerations. Read More

Medicina (Kaunas) 2022 Mar 1;58(3). Epub 2022 Mar 1.

Department of Neurosurgery and Spine Surgery, University Hospital Essen, 45122 Essen, Germany.

Spinal schwannomas are benign tumours that can present with various symptoms such as pain, radiculopathy and neurological deficit. Gross total resection (GTR) is of key importance for local recurrence. The aim of this study is to describe the clinical characteristics, resection rate, clinical outcome, as well as tumour recurrence, in patients with non-syndromic spinal schwannomas and to clarify which factors affect the resection rate. Read More

Hear Res 2022 May 7;418:108458. Epub 2022 Feb 7.

Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA; Eaton Peabody Laboratories and Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA; Department of Otolaryngology, Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Hearing loss in patients with vestibular schwannoma (VS) is commonly attributed to mechanical compression of the auditory nerve, though recent studies suggest that this retrocochlear pathology may be augmented by cochlear damage. Although VS-associated loss of inner hair cells, outer hair cells, and spiral ganglion cells has been reported, it is unclear to what extent auditory-nerve peripheral axons are damaged in VS patients. Understanding the degree of damage VSs cause to auditory nerve fibers (ANFs) is important for accurately modeling clinical outcomes of cochlear implantation, which is a therapeutic option to rehabilitate hearing in VS-affected ears. Read More

Curr Oncol 2022 03 3;29(3):1594-1604. Epub 2022 Mar 3.

Department of Neurosurgery, Saitama Medical Center, Saitama Medical University, Saitama 350-8550, Japan.

This study sought to explore the existence and clinical significance of intratumoral heterogeneity of proliferative potential in vestibular schwannoma (VS). Rapid intraoperative flow cytometry was utilized with raw samples to measure the proliferative ability of VS. The proliferation index (PI) was defined as the ratio of the number of cells with greater than normal DNA content to the total number of cells. Read More

JBJS Case Connect 2022 03 23;12(1). Epub 2022 Mar 23.

Division of Oncology, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois.

Case: A 41-year-old woman with a history of high-grade B-cell lymphoma status-post chemotherapy was evaluated for a painful left posterior thigh mass and significant weakness with sensory changes. Imaging revealed a benign-appearing mass consistent with schwannoma; however, intraoperative frozen section suggested high-grade B-cell lymphoma. Subsequent restaging studies revealed metastatic disease. Read More

Oper Neurosurg (Hagerstown) 2022 May;22(5):e229-e230

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Acta Biomed 2022 Mar 14;93(1):e2022085. Epub 2022 Mar 14.

Department of Orthopaedic and Trauma Surgery, University of Pisa, Pisa, Italy.

Background And Aim Of The Work: Schwannomas of the lower limb are uncommon benign tumors and those arising from Tibial Nerve are particularly rare. We report our experience on the topic, with particular attention to clinical presentation and lower limbs overall functionality before and after treatment. Our aim is to assess clinical impairment caused by the tumor and evaluate the effectiveness of surgical treatment. Read More