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J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):542-547. Epub 2021 Jan 9.

Department of Oral Pathology and Microbiology, GITAM Dental College and Hospital, Andhra Pradesh, India.

Neurilemmoma has been defined as a benign, encapsulated neoplasm that arises in the nerve fiber. It originates from the proliferation of Schwann cells in the perineurium causing displacement and compression of the adjacent nerve. This neoplasm is composed primarily of Schwann cells in a poorly collagenized stroma. Read More

Ear Nose Throat J 2021 May 5:1455613211007947. Epub 2021 May 5.

Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objectives: Neurilemmoma in the nasal cavity and paranasal sinuses is very rare. The study aimed to improve the understanding of neurilemmoma in the nasal cavity and paranasal sinuses.

Materials And Methods: The clinical data of 10 patients with neurilemmoma in the nasal cavity and paranasal sinuses treated from January 2014 to June 2019 in our hospital were retrospectively studied. Read More

Vestn Otorinolaringol 2021 ;86(2):62-65

L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology of the Moscow Department of Healthcare, Russian Federation, Moscow, Russia.

The article presents a review of the literature on the vestibular schwannoma of childhood, the features of its clinical manifestations, diagnostic methods, methods of treating education and indications for their use. Read More

Pan Afr Med J 2021 4;38:128. Epub 2021 Feb 4.

Service de Neurochirurgie du Centre Hospitalier Universitaire Yalgado Ouédraogo de Ouagadougou, Ouagadougou, Burkina Faso.

Intraspinal tumors are uncommon. Positive diagnosis is based on medical imaging exams, in particular MRI. Anatomopathological examination allows for definitive diagnosis. Read More

Medicine (Baltimore) 2021 Apr;100(16):e25517

Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, China.

Rationale: Primary schwannoma of the thyroid gland is very rare, and its preoperative diagnosis is difficult.

Patient Concerns: We report the case of a thyroid nodule in an 18-year-old woman, who presented with a mass in her left neck with stiffness and normal thyroid function. However, the patient complained of numbness in her left upper extremity, and ultrasound (US) features were suspicious of malignancy. Read More

BMC Gastroenterol 2021 Apr 20;21(1):183. Epub 2021 Apr 20.

Department of Radiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan.

Background: Portal hepatic schwannoma is a rare benign tumor and difficult to diagnose preoperatively because of its rarity and imaging manifestations that mimic malignancy. We present a case of portal hepatic schwannoma that showed moderate contrast enhancement on computed tomography (CT), extension along the bile duct on T2-weighted imaging and magnetic resonance cholangiopancreatography (MRCP), and uptake of F-fluorodeoxyglucose (FDG) on positron emission tomography.

Case Presentation: Ultrasonography at an annual health checkup identified a hepatic mass in a 38-year-old woman. Read More

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):75-79

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation, Saint Petersburg, Russia.

The article presents a case of surgical treatment of primary multiple benign tumors of the cauda equine of different histological origin: spinal nerve root schwannoma and ependymoma of the filum terminale. Read More

N Engl J Med 2021 04;384(14):1335-1348

From the Departments of Otolaryngology-Head and Neck Surgery and Neurologic Surgery, Mayo Clinic, Rochester, MN.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Mar;35(3):256-259

Department of Otorhinolaryngology Head and Neck Surgery，the First Affiliated Hospital of Zhengzhou University，Zhengzhou，450052，China.

To improve the diagnosis and treatment of laryngeal schwannoma. The clinical data of 15 patients with laryngeal schwannoma were retrospectively analyzed, including 5 male patients and 10 female patients. The tumors were located in aryepiglottic fold in 4 cases, arytenoid region in 4 cases, interarytenoid in 2 cases, false vocal cord in 2 cases, epiglottis in 1 case, vocal cord in 1 case, and subglottic region in 1 case. Read More

Case Rep Dermatol 2021 Jan-Apr;13(1):164-170. Epub 2021 Mar 3.

Dermatology Department, College of Medicine and University Hospitals, King Saud University, Riyadh, Saudi Arabia.

Schwannoma is a benign neoplasm that originates from the neural sheath of Schwann cells. Although extracranial schwannomas are commonly observed in the head and neck region, only 1% are found in the intraoral cavity. This article describes the first case in the Eastern Mediterranean region of a lower lip schwannoma in a 17-year-old male patient. Read More

Am Fam Physician 2021 04;103(7):393-394

Brisbane, QLD, Australia.

Int J Hyperthermia 2021 ;38(1):552-560

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA.

Oral cancers are one of the commonly diagnosed tumors worldwide in human and veterinary patients. Most oral cancers are surgically resected; however, obtaining an adequate margin of safety in patients without compromising their quality of life is often challenging. Herein, we investigated the ability of non-invasive focused ultrasound (FUS) to thermally ablate a biopsy confirmed canine oral cancer. Read More

An Bras Dermatol 2021 Mar 16. Epub 2021 Mar 16.

Dermatology Department, Faculty of Medicine, Hospital Universitario "Dr. Jose E. Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico. Electronic address:

We report a 40-year-old man, with an unremarkable personal and family history, who presented for evaluation of an asymptomatic papule located on his right cheek. Histopathology revealed an encapsulated neoplasm within the dermis; composed by narrow, elongated, and wavy cells with an ill-defined cytoplasm, dense chromatin and tapered ends interspersed with collagen fibers. Pathologic findings were consistent with tissue of Antoni B pattern. Read More

J Int Med Res 2021 Mar;49(3):300060521999566

Department of Pathology, Inje University School of Medicine, Busan Paik Hospital, Busan, Republic of Korea.

Chordomas are rare, locally aggressive bone malignancies with poor prognoses. However, those with minimal or no bone involvement are more easily resectable because of their well-delineated margins and thus have better prognoses. Such extraosseous chordomas of the spine are localized both intradurally and extradurally. Read More

Ophthalmic Plast Reconstr Surg 2021 Mar 8. Epub 2021 Mar 8.

Adnexal Service, Moorfields Eye Hospital Department of Eye Pathology, UCL Institute of Ophthalmology, London, United Kingdom.

Solitary orbital neurilemmoma-a benign tumor of Schwann cells in a peripheral nerve-sheath-are typically very slow growing and present in middle age; in the absence of neurofibromatosis, they are almost never seen in childhood. We describe the clinical presentation, imaging, pathology, and management of this tumor in a 12 years old-the tumor growing extremely rapidly over 5 months and without any evidence of cystic degeneration, hemorrhage, or sarcomatous features. The possibility of tumor growth having been accelerated by prior biopsy is discussed. Read More

Acta Neurochir (Wien) 2021 Mar 10. Epub 2021 Mar 10.

Department of Surgery, Gaffrée e Guinle University Hospital, School of Medicine, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, RJ, Brazil.

Objective: Data concerning the surgical treatment of lumbosacral plexus tumors (LSPTs) is scarce. This study aims to present our experience with a series of 19 patients surgically treated for symptomatic LSPTs at our institution.

Methods: This is a retrospective study of 19 patients surgically treated for symptomatic LSPTs from 2011 to 2019. Read More

BMC Surg 2021 Mar 10;21(1):128. Epub 2021 Mar 10.

Department of Thoracic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, Jilin, China.

Background: Neurofibromatosis comprises neurofibromatosis type 1 (NF1) and type 2 (NF2). Major tumor type of NF1 are neurofibroma recognized as benign peripheral nerve tumor, malignant peripheral nerve sheath tumor (MPNST), and glioma.

Case Presentation: We report a woman with a special condition, whose tumors in body surfaces were benign neurofibroma and tumors in posterior mediastinum are MPNST. Read More

BMJ Case Rep 2021 Mar 9;14(3). Epub 2021 Mar 9.

Neurology, The London Clinic, London, UK.

Hypnic headache (HH) is a rare, primary headache syndrome that invariably occurs during sleep and wakes the patient. Acoustic neuroma (AN) is a benign tumour that uncommonly presents with isolated headache. Here, we describe a patient with AN that presented with an HH-like syndrome. Read More

Ann R Coll Surg Engl 2021 Apr 8;103(4):e124-e126. Epub 2021 Mar 8.

Royal National Orthopaedic Hospital, Stanmore, UK.

This case report discusses a cervical psammomatous melanotic schwannoma - a rare form of peripheral nerve sheath tumour - which may be highly vascular and is often associated with the Carney complex. Significant intraneural bleeding, which was encountered intraoperatively, was controlled successfully with a gelatine-based thrombin haemostatic agent (Floseal, Baxter International, Deerfield, IL, USA) without complication. Read More

Zhonghua Bing Li Xue Za Zhi 2021 Mar;50(3):288-292

Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Arch Craniofac Surg 2020 Dec 20;21(6):368-371. Epub 2020 Dec 20.

Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea.

Schwannoma, also known as neurilemmoma, is a tumor of the nerve sheath, which most often occurs in the peripheral nerves of the extremities. Schwannoma can be accompanied by symptoms such as pain, paresthesia, and Tinel sign; however, patients can also be asymptomatic. Here, we present the case of a 17-year-old woman who presented with a slowly growing, asymptomatic, postauricular mass that appeared 10 years prior. Read More

Medicine (Baltimore) 2021 Feb;100(8):e24803

PET/CT Center, Shaoxing People's Hospital, the First Affiliated Hospital of Shaoxing University, 568 Zhongxing North Rd, Shaoxing City.

Rationale: Melanotic schwannoma (MS) is an unusual variant of a nerve sheath neoplasm that accounts for less than 1% of all primary peripheral nerve sheath tumors. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has unique value in detecting malignant MS lesions. To date, only 4 cases of MS with hepatic metastasis have been reported. Read More

Gen Dent 2021 Mar-Apr;69(2):28-32

This case report describes an intraosseous neurilemoma, observed radiographically as a multilocular lesion, in a 12-year-old patient. Physical examination revealed facial asymmetry, swelling on the right side of the mandibular body, and bone expansion in the region of the base of the buccal sulcus. Panoramic radiography revealed a multilocular radiolucency on the right side of the mandibular body in the periapical region extending from the distal region of the first premolar root to the second molar and adjacent to the third molar. Read More

Am J Case Rep 2021 Feb 22;22:e929674. Epub 2021 Feb 22.

Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

BACKGROUND Neurofibromas are benign tumors of neurological origin caused by the proliferation of Schwann cells and fibroblasts; they often occur in the skin and nerves as a symptom of von Recklinghausen disease. Solitary neurofibromas are also known to occur on their own, but solitary development in the hard palate is extremely rare and difficult to distinguish from schwannomas. The neural origin of solitary neurofibromas is also difficult to determine intraoperatively, and there have been no reports that clearly identify the neural origin of neurofibromas in the hard palate. Read More

Medicina (B Aires) 2021 ;81(1):130

Sector Cirugía de Cabeza y Cuello, Servicio de Cirugía General, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Mil Med 2021 05;186(5-6):637-642

Department of Otolaryngology-Head and Neck Surgery, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX 78234, USA.

Military personnel are at increased risk of asymmetric hearing loss secondary to noise exposure. This report illustrates the importance of expeditiously evaluating for retrocochlear pathology even in young active duty service members with asymmetric or sudden hearing loss. A 36-year-old male presented with right-sided sudden hearing loss and dizziness. Read More

BMJ Case Rep 2021 Feb 19;14(2). Epub 2021 Feb 19.

Oral & Maxillofacial Department, St George's University Hospitals NHS Foundation Trust, London, UK.

Schwannomas or neurilemmomas are slow-growing, benign and often firm lumps that are typically painless. They are extremely rare in the oral cavity, with the tongue and the palate being the most common intraoral sites. This is a case report of this pathology in the floor of the mouth. Read More

Medicine (Baltimore) 2021 Feb;100(7):e24801

Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai, Hebei Province, China.

Rationale: Orbital schwannoma is a relatively rare orbital tumor, and calcification of the lesion is rarely found in the orbit. We report a case of orbital schwannoma which was characterized by calcification in the orbital muscle cone, and was cured by intracapsular excision.

Patient Concerns: A 54-year-old female with a complaint of a mass in the left orbit during a magnetic resonance imaging examination and symptom of dizziness 6 months before, presented with painless exophthalmos and vision decline in the left eye. Read More

Cancer Imaging 2021 Feb 15;21(1):23. Epub 2021 Feb 15.

Department of Radiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian, China.

Background: There is a paucity of existing literature centering on the magnetic resonance (MR) imaging features of pancreatic schwannomas, due to the neoplasm's nonspecific presentation and its rarity. We aimed to identify the characteristic imaging features of pancreatic schwannoma.

Methods: This retrospective search was conducted for histologically confirmed pancreatic schwannoma in multi-institutional database of pathology. Read More

Neurosurgery 2021 02;88(3):443-456

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Neoplasms of the peripheral nervous system represent a heterogenous group with a wide spectrum of morphological features and biological potential. They range from benign and curable by complete excision (schwannoma and soft tissue perineurioma) to benign but potentially aggressive at the local level (plexiform neurofibroma) to the highly malignant (malignant peripheral nerve sheath tumors [MPNST]). In this review, we discuss the diagnostic and pathologic features of common peripheral nerve sheath tumors, particularly those that may be encountered in the intracranial compartment or in the spine and paraspinal region. Read More