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Kyobu Geka 2020 Feb;73(2):157-159

Department of Thoracic Surgery, Shizuoka General Hospital, Shizuoka, Japan.

A 18-year-old man was referred to our hospital complaining of chest abnormal shadow of the left upper lung field in mass screening chest X-ray. Although his left anterior chest wall swelled, he did not recognize that. Computed tomography and magnetic resonance imaging demonstrated a dumbbell shaped tumor of the left 1st intercostal space which had grown both inside and outside the thoracic cavity. Read More

Spec Care Dentist 2020 May 8;40(3):303-307. Epub 2020 May 8.

Department of Restorative Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Aim: The present study aimed to report a case of orofacial pain secondary to acoustic neuroma (AN).

Methods And Results: A 66-year-old female presented with unilateral facial pain and odontalgia. The pain was described as throbbing, dull, and constant. Read More

Acta Otolaryngol 2020 Apr 29:1-5. Epub 2020 Apr 29.

Department of Neurosurgery, Universidade de Sao Paulo, São Paulo, Brazil.

Acoustic neuroma (AN) is a well-recognized cause of neurological morbidity, peripheral facial paralysis being one of the most prevalent. Phonatory dysfunction in the late post-operative term has not been properly addressed so far. The objective of this study is to describe the outcomes of phonatory function on the long-term follow-up of AN surgery and identify its prognostic factors. Read More

Rev Bras Ortop (Sao Paulo) 2020 Apr 19;55(2):258-262. Epub 2019 Dec 19.

Hospital AC Camargo Câncer Center de São Paulo, São Paulo, SP, Brasil.

Schwannoma is a benign neural sheath tumor of the soft tissue, and its intraosseous presentation is very rare. It is estimated that intraosseous schwannomas represent 0.2% of all bone tumors. Read More

Eur J Ophthalmol 2020 Apr 28:1120672120920211. Epub 2020 Apr 28.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To report a rare case of intraocular schwannoma with extrascleral extension in a patient with juvenile idiopathic arthritis and to review the literature for this topic.

Methods: Case report.

Results: A 19-year-old male with a history of juvenile idiopathic arthritis was referred for diagnosis and management of an episcleral mass, initially thought to be focal nodular scleritis. Read More

World J Clin Cases 2020 Apr;8(7):1271-1277

Department of Orthopedics, The Third Affiliated Hospital of Guangzhou Medical University, Guanzhou 510000, Guandong Province, China.

Background: Spinal intraosseous schwannomas (SIS) are rare, and as yet have not been fully described in the literature. The first case of SIS was reported in 1971, and 24 cases of SIS have been reported so far. However, including the present case, there are only seven cases without spinal canal and neuroforamina involvement. Read More

Head Neck Pathol 2020 Apr 8. Epub 2020 Apr 8.

Department of Diagnostic Sciences, Texas A&M University College of Dentistry, Dallas, USA.

Plexiform schwannoma represents an unusual schwannoma variant, characterized by multinodular growth grossly and/or microscopically. A review of the English-language literature reveals only 28 previously reported cases involving the oral cavity, and herein we present 8 additional cases. Among these 36 patients, the average age at diagnosis was 28 years (range 5 to 62 years), with a female-to-male ratio of 1. Read More

Clin Exp Otorhinolaryngol 2020 May 4;13(2):203-208. Epub 2020 Apr 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Objectives: To evaluate the feasibility of brachial plexus schwannoma enucleation under intraoperative neuromonitoring.

Methods: Five patients who were treated for brachial plexus schwannoma under intraoperative neuromonitoring from 2008 to 2018 were included in this retrospective review. Neuromonitoring was performed with a 100-μV event threshold of the neuromonitoring system (NIM-2 or 3) at the deltoid, biceps brachii, triceps brachii, and brachioradialis muscles. Read More

Medicine (Baltimore) 2020 Mar;99(13):e19651

Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Sichuan Province, China.

Rationale: Intracranial solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) are rare spindle cell tumors of mesenchymal origin that include benign and malignant neoplasms.

Patient Concerns: We present a 66-year-old male with a 5-year history of headache and dizziness, with left progressive sensorineural hearing loss over 1 month.

Diagnoses: WHO grade II SFT/HPC originating from the internal auditory canal in the left cerebellopontine angle. Read More

World Neurosurg 2020 04;136:430

Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.

World Neurosurg 2020 04;136:428-429

Department of Neurosurgery, Bezmialem Vakif University, Istanbul, Turkey. Electronic address:

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

Zhonghua Yi Xue Za Zhi 2020 Mar;100(8):619-623

Department of Surgery, the first affiliated hospital of Soochow University, Suzhou 215001, China.

To investigate the neuroprotective effect of facial nerve monitoring on acoustic schwannoma resection and its impact on prognosis. Eighty patients with acoustic schwannomas were enrolled in our study in the past 2 years and randomly divided into a monitoring group and a non-monitoring group. Tumor size was measured by MRI, and the general condition of the patients were analyzed. Read More

World Neurosurg 2020 03;135:401

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, People's Republic of China; China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China; Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, People's Republic of China; Beijing Key Laboratory of Brain Tumor, Beijing, People's Republic of China. Electronic address:

World Neurosurg 2020 03;135:399-400

Department of Pathology, SGPGIMS, Lucknow, India.

World Neurosurg 2020 03;135:392

Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea; Department of Neurosurgery, Kyung Hee University College of Medicine, Seoul, Korea.

World Neurosurg 2020 03;135:390-391

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Breast Dis 2020 Feb 17. Epub 2020 Feb 17.

Departamento de Patologia, Hospital de Câncer de Barretos, São Paulo, Brazil.

Background: Schwannoma is an extremely rare benign tumour of the peripheral nervous system; its association with breast cancer is sporadic, and its association with the brachial plexus is extremely rare.

Case Description: The authors report a case of a patient with breast cancer associated with nodulation in the left supraclavicular fossa, and due to the clinical and radiological features, it was considered metastatic lymph node disease. The patient underwent neoadjuvant chemotherapy, with partial response of the breast. Read More

Zhonghua Yi Xue Za Zhi 2020 Feb;100(4):274-278

Department of Neurosurgery, Tian Tan Hospital of Capital Medical University, Beijing 100071, China.

To explore the application, advantages and disadvantages of minimally invasive surgery for lumbar schwannoma. this study was a prospective, non-randomized controlled study with a trial group (minimally invasive surgery group) and a control group (traditional laminectomy group).For the patients with lumbar schwannoma hospitalized in the neurosurgical spinal ward of Beijing Tian Tan hospital, the surgeon communicated with them one-on-one to inform the patients of the advantages and disadvantages of minimally invasive surgery through channels and traditional laminectomy. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;55(2):87-93

Department of Otorhinolaryngology Head and Neck Surgery, the Affiliated Hospital of Qingdao University, Otorhinolaryngology Head and Neck Surgery Key Laboratory of Shandong Province, Qingdao 266003, China; Department of Skull Base Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China; Department of Allergy, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

To explore the application of endoscopy and clinical effect of endoscopic resection of benign tumor in infratemporal fossa. The clinical data of 11 patients with benign tumors in infratemporal fossa admitted to the Department of Otorhinolaryngology Head and Neck Surgery and Skull Base Surgery of the Affiliated Hospital of Qingdao University from January 2016 to September 2018 were retrospectively analyzed. There were 6 males and 5 females, with the age ranging from 11 to 63 years old. Read More

Can Assoc Radiol J 2020 May 22;71(2):161-173. Epub 2020 Jan 22.

Department of Radiology, University of Chicago, Chicago, IL, USA.

Imaging studies of the hands and fingers are common, and radiologists are generally comfortable with traumatic and degenerative conditions which arise frequently in daily practice. However, a variety of common and uncommon soft-tissue tumors also occur in the hand, the appropriate diagnosis of which can be a source of confusion for both clinicians and radiologists. These lesions often have overlapping imaging characteristics; however, a structured approach can help provide a focused differential diagnosis and impact further workup and management. Read More

World Neurosurg 2020 02;134:683

Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. Electronic address:

World Neurosurg 2020 02;134:682

Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.

J Laryngol Otol 2020 03 10;134(3):275-276. Epub 2020 Feb 10.

Department of Skull Base Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, UK.

Medicine (Baltimore) 2020 Jan;99(3):e18797

Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, P.R. China.

Rationale: Schwannomas are neoplasms that originate from Schwann cells of the peripheral nerve sheath with a low malignant potential. Considering that Schwannomas often occur in the upper extremities, trunk, head, and neck, but in the hepatoduodenal ligament has seldom been reported.

Patient Concerns: A 70-year-old man was referred to our hospital for further evaluation of distension in upper abdomen. Read More

World Neurosurg 2020 Apr 27;136:295-300. Epub 2020 Jan 27.

Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA. Electronic address:

Background: Symptomatic peritumoral edema (PTE) is a known complication after radiosurgical treatment of meningiomas. Although the edema in most patients can be successfully managed conservatively with corticosteroid therapy or bevacizumab, some medically refractory cases may require surgical resection of the underlying lesion when feasible. Laser interstitial thermotherapy (LITT) continues to gain traction as an effective therapeutic modality for the treatment of radiation necrosis where its biggest impact is through the control of peritumoral edema. Read More

Medicine (Baltimore) 2020 Jan;99(5):e18814

College of Medicine and Medical Research Institute.

Rationale: Schwannomas involving the thyroid gland are very rare and only a few cases have been reported in the literature. However, previous reports did not distinguish between thyroid bed schwannomas and intrathyroidal schwannomas. Here, we report a thyroid bed schwannoma mimicking a malignant thyroid nodule and review the literature on thyroid bed schwannomas. Read More

No Shinkei Geka 2020 Jan;48(1):71-77

Department of Neurosurgery, Kitasato University School of Medicine.

A 67-year-old male presenting with left exophthalmos and progressive visual disturbance was referred to our department. Tumors at the supraclavicular fossa and dorsal femoral region were resected at ages 27 and 45 years. His father and son had both been diagnosed with spinal tumors, and his son's tumor was pathologically diagnosed as a schwannoma. Read More

Ann Ital Chir 2020 Jan 20;9. Epub 2020 Jan 20.

Ancient Schwannoma is a type of peripheral neurogenic tumor formed by the Schwann cells presenting mainly as a benign and asymptomatic lesion. The neurilemmoma tumor appears in different sites and, in cases of cervical location, can mimic a carotid body tumor. Herein we describe a clinical case of a 51-year-old woman with latero-cervical swelling. Read More

Neurol Neurochir Pol 2020 20;54(1):73-82. Epub 2020 Jan 20.

Medical University of Gdańsk, Neurosurgery Department, Debinki 7, 81-952 Gdańsk, Poland.

Aim Of The Study: This study aimed to verify the accuracy of preoperative visualisation of the facial nerve (FN) by magnetic resonance-based (MR) diffusion tensor imaging-fibre tracking (DTI-FT) with neuronavigation system integration in patients with cerebello-pontine angle (CPA) tumours.

Clinical Rationale For The Study: Complete excision with preservation of the FN remains the critical goal of today's vestibular schwannoma (VS) surgery. DTI-FT of the FN with neuronavigation is yet to be fully evaluated, and could make surgery safer. Read More

Kyobu Geka 2020 Jan;73(1):76-79

Department of Thoracic Surgery, Nakatsu General Hospital, Osaka, Japan.

A 73-year-old man visited his family doctor with complaints of cough and breathlessness. Right pleural effusion was detected by chest X-ray. Computed tomography(CT) showed a huge mass 13×11 cm in the right mediastinum along with right pleural effusion and atelectasis of the right middle and lower lobes. Read More

World Neurosurg 2020 Apr 10;136:e440-e446. Epub 2020 Jan 10.

Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

Objective: To explore patient demographics as to predicting vestibular schwannoma (VS) size and treatment plan within a single institution.

Methods: Using a large tertiary referral skull base center database, all patients with sporadic VS who presented to the center between 2009 and 2018 were reviewed.

Results: A total of 816 patients with VS over 18 years of age were included. Read More

Isr Med Assoc J 2020 Jan;22(1):53-59

Department of General Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Primary retroperitoneal neoplasms (PRN) arise from diverse retroperitoneal tissues. Soft tissue sarcomas (STS) comprise the majority and are well studied. Other non-sarcomatous PRN are very rare and less familiar. Read More

PLoS One 2020 10;15(1):e0225638. Epub 2020 Jan 10.

Instituto de Radioproteção e Dosimetria / Comissão Nacional de Energia Nuclear-IRD / CNEN, Rio de Janeiro, Brazil.

Introduction: This study explores the possibility of a relationship between the sphericity degree of a target volume with the dose distribution. This relationship is evaluated based on the ratio isodose volume / target volume (IV/TV) and the metrics coverage, i.e. Read More

Arch Craniofac Surg 2019 Dec 20;20(6):388-391. Epub 2019 Dec 20.

Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea.

Schwannoma is a slow-growing, well-demarcated, benign soft tissue tumor of the peripheral nerve sheath. It commonly develops in the head and neck region, usually in the parapharyngeal space. In this case, a 42-year-old woman visited the outpatient department to manage a painless mass on her left cheek. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Nov;33(11):1053-1056

Department of Otorhinolaryngology Head and Neck Surgery，General Hospital of Chinese People's Liberation Army，Beijing，100853，China.

We aimed to provide a basis for the clinical study of acoustic neuroma through investigating the ability of temporal gap detection in acoustic neuroma patients and comparing the abilities with those in people with normal and impaired hearing. Twenty-two patients with confirmed acoustic neuroma, 30 normal hearing patients and 16 patients with sensorineural hearing loss were enrolled in this study, and the interval threshold for awareness of each group was tested. The mean temporal gap detection test（TGDT） threshold of the normal hearing group was （3. Read More

World Neurosurg 2020 Apr 2;136:e262-e269. Epub 2020 Jan 2.

Department of Neurosurgery, Hospital Clínico Universitario de Valencia, Valencia, Spain; Microneurosurgery Laboratory, Department of Anatomy and Human Embriology, University Valencia, Valencia, Spain; Mayo Clinic College of Medicine and Science, Jacksonville, Florida, USA.

Background: Facial paralysis secondary to a complete and irreversible anatomic or functional lesion of the facial nerve (FN) causes severe functional and psychological disorders for the patient. A large number of surgical techniques have therefore been developed for FN repair. Our objective was to propose a surgical FN reanimation protocol for patients with irreversible anatomic or functional postsurgical injury of the FN in the cerebellopontine angle after vestibular schwannoma resection. Read More

Cureus 2019 Nov 25;11(11):e6231. Epub 2019 Nov 25.

Pathology, Bahçeşehir University, Faculty of Medicine, İstanbul, TUR.

Schwannomas are common, well-encapsulated benign tumors of the peripheral nerves. They rarely emerge from the median nerve in the forearm. Here we report a case of an unusual schwannoma measuring 3 × 4 × 3 cm originating from the median nerve in the proximal forearm of a 49-year-old man. Read More

World Neurosurg 2020 Mar 27;135:e686-e694. Epub 2019 Dec 27.

Department of Neurotomy, Beijing Neurosurgical Institute, Beijing, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: To describe the morphology and anatomical relationship of the jugular process (JP) and to elucidate its utility as a surgical landmark in the lateraland posterior lateral approaches to the jugular foramen.

Materials And Methods: Eight dry adult skulls and 10 silicon-injected cadaver heads were used for this study. The distances to selected structures and the thickness of the JP at 3 selected sites were measured. Read More

World Neurosurg 2020 Mar 25;135:267-272. Epub 2019 Dec 25.

Spinal Disorders Center, Fujieda Heisei Memorial Hospital, Fujieda City, Shizuoka, Japan.

Background: Sacral schwannomas are rare tumors arising from nerve sheath Schwann cells. They are classified into 3 types: first type schwannoma arising from the sacrum, second type schwannoma eroding the sacrum, and third type schwannoma extending extensively, involving anterior, posterior, and retroperitoneal space. Among these type 2 sacral tumors, according to Klimo's classification, an eroding sacrum extending all over posteriorly, anteriorly, and laterally is still rarer. Read More

J Exp Ther Oncol 2019 Dec;13(2):155-158

Department of Neurosurgery, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Objective: Schwannomas are benign slow growing tumors that arise from myelin producing Schwann cells. Schwannomas developing in cervical-dorsal region are rare benign neoplasms which are emerges leisurely remains asymptomatic some times and functionally inactive tumours. Giant Schwannomas extending over two or more vertebral levels have been documented and attempts have been made to classify these in available literature, however inadequate. Read More

Kyobu Geka 2019 Dec;72(13):1123-1125

Department of Thoracic Surgery, Iizuka Hospital, Iizuka, Japan.

Schwannomatosis with mediastinal vagal schwannoma is rare. A 71-year-old man presented with multiple mediastinal tumors by a regular check-up. A chest computed tomography showed well-defined round tumors along with the 3rd intercostal nerve and in the left upper mediastinal area. Read More

No Shinkei Geka 2019 Dec;47(12):1223-1229

Spine and Spinal Cord Center, Aichi Medical University.

World Neurosurg 2020 Mar 21;135:171-172. Epub 2019 Dec 21.

Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Benign peripheral nerve sheath tumors are well known to neurosurgeons and a relatively commonly seen pathology. Intraneural ganglion cysts, once thought to be rare and poorly understood, are increasingly recognized in clinical practice and better understood based on the advent of high-resolution imaging. There are few reports of different nerve lesions in the same anatomic location appearing concurrently. Read More

PLoS One 2019 23;14(12):e0226607. Epub 2019 Dec 23.

Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.

Purpose: The aim of this study was to analyze the utility of various preoperative electrophysiological tests of the facial nerve CNVII in predicting CNVII function after vestibular schwannoma surgery.

Methods: This retrospective study included 176 patients who had preoperative facial nerve electroneurography and electrically evoked blink reflex testing. We defined the following variables: axonal degeneration of CNVII (AD-CNVII), trigeminal nerve damage (D-CNV), disturbances in the short-latency pathway of the blink reflex (D-BR), and any changes in electrophysiological test results (A-EMG). Read More

Medicine (Baltimore) 2019 Dec;98(51):e18180

Department of Cardiothoracic Surgery, the Third Affiliated Hospital, Sun Yat-sen University.

Rationale: Primary schwannoma is extremely rare in the trachea, and its optimal treatment has not yet been established. Previous literature have indicated that traditional resection by thoracotomy is an effective surgical procedure but with huge trauma, and endoscopic excision is a minimally invasive surgical method but with possibility of recurrence. Window resection was usually utilized for selected patients with trachea invasion by thyroid carcinoma, but video-assisted thoracoscopic window resection for trachea schwannoma has not been reported previously. Read More

Medicine (Baltimore) 2019 Dec;98(51):e18149

Department of Vascular Surgery, Azienda Ospedaliera Brotzu, Cagliari, Italy.

Rationale: Retroperitoneal schwannomas are very rare and may grow very close to major abdominal vessels. Since the surgical approach to the retroperitoneal space may be complex due to surrounding vital organs, including major vessels, laparoscopic surgery is challenging and has only been recently adopted. Here, we report a case of laparoscopic resection of a large retroperitoneal schwannoma attached to large vital vessels. Read More

Nagoya J Med Sci 2019 Nov;81(4):701-705

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

A 58-year-old woman presented with acute pain in her back and her left leg. Magnetic resonance imaging (MRI) revealed an intradural schwannoma with an intratumoral hemorrhage between the lower L4 vertebra and L5/S1 disk level. A follow-up MRI after one month revealed that the tumor had regressed from the middle of L5 to the L5/S1 disk level. Read More

Nat Commun 2019 12 17;10(1):5758. Epub 2019 Dec 17.

Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

The anti-VEGF antibody bevacizumab has shown efficacy for the treatment of neurofibromatosis type 2 (NF2). Theoretically, vascular endothelial growth factor receptors (VEGFRs)-specific cytotoxic T lymphocytes (CTLs) can kill both tumor vessel cells and tumor cells expressing VEGFRs. Here we show an exploratory clinical study of VEGFRs peptide vaccine in seven patients with progressive NF2-derived schwannomas. Read More

J Int Adv Otol 2019 Dec;15(3):415-419

Department of Otorhinolaryngology-Head - Neck Surgery, Asan Medical Center, Seoul, Korea, Republic Of.

Objectives: The aim of this study was to evaluate the preoperative and postoperative facial nerve (FN) function in patients with FN schwannoma (FNS) and analyze the duration of preoperative facial palsy according to the preoperative and postoperative facial function.

Materials And Methods: We retrospectively reviewed the medical records of 29 patients with FNS who underwent surgery. We evaluated the FN function according to the type of FN manipulation and location of the anastomoses in the cable nerve graft, and we also analyzed the duration of facial palsy according to the facial function before and after surgery. Read More