370 results match your criteria Neural Development [Journal]


Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors.

Neural Dev 2019 Feb 14;14(1). Epub 2019 Feb 14.

Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, Box 511, New York, NY, 10065, USA.

Background: The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependent proliferation of ATOH1+ granule cell precursors (GCPs) in the external granule cell layer (EGL), a key step for generating cerebellar foliation and the correct number of granule cells. Due to its late development, the cerebellum is particularly vulnerable to injury from preterm birth and stress around birth. Read More

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http://dx.doi.org/10.1186/s13064-019-0128-yDOI Listing
February 2019

TrkB expression and dependence divides gustatory neurons into three subpopulations.

Neural Dev 2019 01 28;14(1). Epub 2019 Jan 28.

Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 511 S. Floyd St., MDR Building Room 111, Louisville, KY, 40202, USA.

Background: During development, gustatory (taste) neurons likely undergo numerous changes in morphology and expression prior to differentiation into maturity, but little is known this process or the factors that regulate it. Neuron differentiation is likely regulated by a combination of transcription and growth factors. Embryonically, most geniculate neuron development is regulated by the growth factor brain derived neurotrophic factor (BDNF). Read More

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http://dx.doi.org/10.1186/s13064-019-0127-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350382PMC
January 2019
3.453 Impact Factor

An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.

Neural Dev 2019 01 18;14(1). Epub 2019 Jan 18.

Department of Neurobiology, University of Chicago, Chicago, IL, USA.

Background: Mammalian motor circuits display remarkable cellular diversity with hundreds of motor neuron (MN) subtypes innervating hundreds of different muscles. Extensive research on limb muscle-innervating MNs has begun to elucidate the genetic programs that control animal locomotion. In striking contrast, the molecular mechanisms underlying the development of axial muscle-innervating MNs, which control breathing and spinal alignment, are poorly studied. Read More

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https://neuraldevelopment.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s13064-018-0125-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339399PMC
January 2019
5 Reads

Degeneration of saccular hair cells caused by MITF gene mutation.

Neural Dev 2019 01 11;14(1). Epub 2019 Jan 11.

Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Key Laboratory of Hearing Impairment Science, Chinese PLA Medical School, Beijng, China.

Background: Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. Patients with WS may also experience primary vestibular symptoms. Most of the current WS studies did not discuss the relationship between WS and abnormal vestibular function. Read More

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https://neuraldevelopment.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s13064-019-0126-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330439PMC
January 2019
4 Reads

The absence of retinal input disrupts the development of cholinergic brainstem projections in the mouse dorsal lateral geniculate nucleus.

Neural Dev 2018 12 12;13(1):27. Epub 2018 Dec 12.

Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 511 S. Floyd St, Louisville, KY, 40292, USA.

Background: The dorsal lateral geniculate nucleus (dLGN) of the mouse has become a model system for understanding thalamic circuit assembly. While the development of retinal projections to dLGN has been a topic of extensive inquiry, how and when nonretinal projections innervate this nucleus remains largely unexplored. In this study, we examined the development of a major nonretinal projection to dLGN, the ascending input arising from cholinergic neurons of the brainstem. Read More

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http://dx.doi.org/10.1186/s13064-018-0124-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291928PMC
December 2018
1 Read

Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1.

Neural Dev 2018 11 22;13(1):26. Epub 2018 Nov 22.

Department of Biology, The City College of New York, City University of New York, New York, NY, 10031, USA.

Background: Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors or to generate new functional photoreceptors to replace those lost in the diseased retina. Cis-regulatory elements specific to cones, rods, or both types of photoreceptors are critical components of successful implementation of these two strategies. Read More

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http://dx.doi.org/10.1186/s13064-018-0121-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251108PMC
November 2018
13 Reads

Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe.

Neural Dev 2018 11 22;13(1):25. Epub 2018 Nov 22.

The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.

Background: Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells progress through two transient progenitor states, PI and PII, before transforming into neuroblasts. Here we analyse the role of Notch signalling in the transition from neuroepithelial cells to neuroblasts. Read More

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http://dx.doi.org/10.1186/s13064-018-0123-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251220PMC
November 2018
1 Read
3.453 Impact Factor

Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish.

Neural Dev 2018 11 17;13(1):24. Epub 2018 Nov 17.

Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.

Background: Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal cord injury. The mammalian spinal cord shows very limited regeneration and neurogenesis, resulting in permanent life-long functional impairment. Therefore, there is an urgent need to identify the cellular and molecular mechanisms that can drive efficient vertebrate neurogenesis following injury. Read More

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http://dx.doi.org/10.1186/s13064-018-0122-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240426PMC
November 2018
2 Reads

Live imaging of developing mouse retinal slices.

Neural Dev 2018 09 15;13(1):23. Epub 2018 Sep 15.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.

Background: Ex vivo, whole-mount explant culture of the rodent retina has proved to be a valuable approach for studying retinal development. In a limited number of recent studies, this method has been coupled to live fluorescent microscopy with the goal of directly observing dynamic cellular events. However, retinal tissue thickness imposes significant technical limitations. Read More

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https://neuraldevelopment.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s13064-018-0120-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139133PMC
September 2018
6 Reads

DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring.

Neural Dev 2018 09 15;13(1):22. Epub 2018 Sep 15.

Department of Neurobiology and Behavior, University of California, Irvine, 2205 McGaugh Hall, Irvine, CA, 92697-4550, USA.

Background: Proper patterning of dendritic and axonal arbors is a critical step in the formation of functional neuronal circuits. Developing circuits rely on an array of molecular cues to shape arbor morphology, but the underlying mechanisms guiding the structural formation and interconnectivity of pre- and postsynaptic arbors in real time remain unclear. Here we explore how Down syndrome cell adhesion molecule (DSCAM) differentially shapes the dendritic morphology of central neurons and their presynaptic retinal ganglion cell (RGC) axons in the developing vertebrate visual system. Read More

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http://dx.doi.org/10.1186/s13064-018-0118-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138929PMC
September 2018
1 Read

Genomic analysis of transcriptional networks directing progression of cell states during MGE development.

Neural Dev 2018 09 14;13(1):21. Epub 2018 Sep 14.

Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, 94143, USA.

Background: Homeodomain (HD) transcription factor (TF) NKX2-1 critical for the regional specification of the medial ganglionic eminence (MGE) as well as promoting the GABAergic and cholinergic neuron fates via the induction of TFs such as LHX6 and LHX8. NKX2-1 defines MGE regional identity in large part through transcriptional repression, while specification and maturation of GABAergic and cholinergic fates is mediated in part by transcriptional activation via TFs such as LHX6 and LHX8. Here we analyze the signaling and TF pathways, downstream of NKX2-1, required for GABAergic and cholinergic neuron fate maturation. Read More

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http://dx.doi.org/10.1186/s13064-018-0119-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138899PMC
September 2018
1 Read

Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies.

Neural Dev 2018 09 13;13(1):20. Epub 2018 Sep 13.

Institute for Clinical Neuroanatomy, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany.

Remarkable progress in a range of biomedical disciplines has promoted the understanding of the cellular components of the autonomic nervous system and their differentiation during development to a critical level. Characterization of the gene expression fingerprints of individual neurons and identification of the key regulators of autonomic neuron differentiation enables us to comprehend the development of different sets of autonomic neurons. Their individual functional properties emerge as a consequence of differential gene expression initiated by the action of specific developmental regulators. Read More

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http://dx.doi.org/10.1186/s13064-018-0117-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137933PMC
September 2018
2 Reads

Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.

Neural Dev 2018 08 18;13(1):19. Epub 2018 Aug 18.

Department of Biological Sciences, University of Notre Dame, 015 Galvin Life Sciences Building, Notre Dame, IN, 46556, USA.

Background: Glial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathment of neuronal cell somas, especially during early development when neurons are extending processes and progenitor populations are expanding, is still largely unknown.

Methods: To address this, we used time-lapse imaging in zebrafish during the initial formation of the dorsal root ganglia (DRG). Read More

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http://dx.doi.org/10.1186/s13064-018-0115-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098834PMC
August 2018
3 Reads

Identification and characterization of mushroom body neurons that regulate fat storage in Drosophila.

Neural Dev 2018 08 13;13(1):18. Epub 2018 Aug 13.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

Background: In an earlier study, we identified two neuronal populations, c673a and Fru-GAL4, that regulate fat storage in fruit flies. Both populations partially overlap with a structure in the insect brain known as the mushroom body (MB), which plays a critical role in memory formation. This overlap prompted us to examine whether the MB is also involved in fat storage homeostasis. Read More

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https://neuraldevelopment.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s13064-018-0116-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090720PMC
August 2018
11 Reads

Mutations in dock1 disrupt early Schwann cell development.

Neural Dev 2018 08 8;13(1):17. Epub 2018 Aug 8.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Background: In the peripheral nervous system (PNS), specialized glial cells called Schwann cells produce myelin, a lipid-rich insulating sheath that surrounds axons and promotes rapid action potential propagation. During development, Schwann cells must undergo extensive cytoskeletal rearrangements in order to become mature, myelinating Schwann cells. The intracellular mechanisms that drive Schwann cell development, myelination, and accompanying cell shape changes are poorly understood. Read More

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http://dx.doi.org/10.1186/s13064-018-0114-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083577PMC
August 2018
2 Reads

Does experience provide a permissive or instructive influence on the development of direction selectivity in visual cortex?

Neural Dev 2018 07 12;13(1):16. Epub 2018 Jul 12.

Department of Biology, Brandeis University, 415 South St. MS008, Waltham, MA, 02454, USA.

In principle, the development of sensory receptive fields in cortex could arise from experience-independent mechanisms that have been acquired through evolution, or through an online analysis of the sensory experience of the individual animal. Here we review recent experiments that suggest that the development of direction selectivity in carnivore visual cortex requires experience, but also suggest that the experience of an individual animal cannot greatly influence the parameters of the direction tuning that emerges, including direction angle preference and speed tuning. The direction angle preference that a neuron will acquire can be predicted from small initial biases that are present in the naïve cortex prior to the onset of visual experience. Read More

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http://dx.doi.org/10.1186/s13064-018-0113-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044012PMC
July 2018
7 Reads

Structural aspects of plasticity in the nervous system of Drosophila.

Neural Dev 2018 07 1;13(1):14. Epub 2018 Jul 1.

Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany.

Neurons extend and retract dynamically their neurites during development to form complex morphologies and to reach out to their appropriate synaptic partners. Their capacity to undergo structural rearrangements is in part maintained during adult life when it supports the animal's ability to adapt to a changing environment or to form lasting memories. Nonetheless, the signals triggering structural plasticity and the mechanisms that support it are not yet fully understood at the molecular level. Read More

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http://dx.doi.org/10.1186/s13064-018-0111-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026517PMC
July 2018
6 Reads

Postnatal developmental dynamics of cell type specification genes in Brn3a/Pou4f1 Retinal Ganglion Cells.

Neural Dev 2018 06 29;13(1):15. Epub 2018 Jun 29.

Retinal Circuit Development & Genetics Unit, Building 6, Room 331B Center Drive, Bethesda, MD, 20892-0610, USA.

Background: About 20-30 distinct Retinal Ganglion Cell (RGC) types transmit visual information from the retina to the brain. The developmental mechanisms by which RGCs are specified are still largely unknown. Brn3a is a member of the Brn3/Pou4f transcription factor family, which contains key regulators of RGC postmitotic specification. Read More

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http://dx.doi.org/10.1186/s13064-018-0110-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025728PMC
June 2018
17 Reads

Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish.

Neural Dev 2018 06 26;13(1):13. Epub 2018 Jun 26.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St/LRB815, Worcester, MA, USA.

Background: Previous work aimed at understanding the gene regulatory networks (GRNs) governing caudal hindbrain formation identified morphogens such as Retinoic Acid (RA) and Fibroblast growth factors (FGFs), as well as transcription factors like hoxb1b, hoxb1a, hnf1ba, and valentino as being required for rhombomere (r) r4-r6 formation in zebrafish. Considering that the caudal hindbrain is relatively complex - for instance, unique sets of neurons are formed in each rhombomere segment - it is likely that additional essential genes remain to be identified and integrated into the caudal hindbrain GRN.

Methods: By taking advantage of gene expression data available in the Zebrafish Information Network (ZFIN), we identified 84 uncharacterized genes that are expressed in r4-r6. Read More

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http://dx.doi.org/10.1186/s13064-018-0112-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020313PMC
June 2018
9 Reads

Strategies for assembling columns and layers in the Drosophila visual system.

Neural Dev 2018 06 7;13(1):11. Epub 2018 Jun 7.

School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

A striking feature of neural circuit structure is the arrangement of neurons into regularly spaced ensembles (i.e. columns) and neural connections into parallel layers. Read More

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http://dx.doi.org/10.1186/s13064-018-0106-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991427PMC
June 2018
1 Read

Assembly and maintenance of GABAergic and Glycinergic circuits in the mammalian nervous system.

Neural Dev 2018 06 7;13(1):12. Epub 2018 Jun 7.

Department of Biological Structure, University of Washington, Seattle, WA, USA.

Inhibition in the central nervous systems (CNS) is mediated by two neurotransmitters: gamma-aminobutyric acid (GABA) and glycine. Inhibitory synapses are generally GABAergic or glycinergic, although there are synapses that co-release both neurotransmitter types. Compared to excitatory circuits, much less is known about the cellular and molecular mechanisms that regulate synaptic partner selection and wiring patterns of inhibitory circuits. Read More

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http://dx.doi.org/10.1186/s13064-018-0109-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991458PMC
June 2018
6 Reads

Development, functional organization, and evolution of vertebrate axial motor circuits.

Neural Dev 2018 06 1;13(1):10. Epub 2018 Jun 1.

Neuroscience Institute, Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY, 10016, USA.

Neuronal control of muscles associated with the central body axis is an ancient and essential function of the nervous systems of most animal species. Throughout the course of vertebrate evolution, motor circuits dedicated to control of axial muscle have undergone significant changes in their roles within the motor system. In most fish species, axial circuits are critical for coordinating muscle activation sequences essential for locomotion and play important roles in postural correction. Read More

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http://dx.doi.org/10.1186/s13064-018-0108-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984435PMC
June 2018
2 Reads

Homeostatic plasticity in neural development.

Neural Dev 2018 06 1;13(1). Epub 2018 Jun 1.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, USA.

Throughout life, neural circuits change their connectivity, especially during development, when neurons frequently extend and retract dendrites and axons, and form and eliminate synapses. In spite of their changing connectivity, neural circuits maintain relatively constant activity levels. Neural circuits achieve functional stability by homeostatic plasticity, which equipoises intrinsic excitability and synaptic strength, balances network excitation and inhibition, and coordinates changes in circuit connectivity. Read More

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http://dx.doi.org/10.1186/s13064-018-0105-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984303PMC
June 2018
1 Read

Tcf7L2 is essential for neurogenesis in the developing mouse neocortex.

Neural Dev 2018 05 11;13(1). Epub 2018 May 11.

Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1084, 14200, Prague, Czech Republic.

Generation of neurons in the embryonic neocortex is a balanced process of proliferation and differentiation of neuronal progenitor cells. Canonical Wnt signalling is crucial for expansion of radial glial cells in the ventricular zone and for differentiation of intermediate progenitors in the subventricular zone. We detected abundant expression of two transcrtiption factors mediating canonical Wnt signalling, Tcf7L1 and Tcf7L2, in the ventricular zone of the embryonic neocortex. Read More

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http://dx.doi.org/10.1186/s13064-018-0107-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946422PMC
May 2018
16 Reads

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development.

Neural Dev 2018 05 1;13(1). Epub 2018 May 1.

Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA, 92037, USA.

In the mammalian cerebral cortex neurons are arranged in specific layers and form connections both within the cortex and with other brain regions, thus forming a complex mesh of specialized synaptic connections comprising distinct circuits. The correct establishment of these connections during development is crucial for the proper function of the brain. Astrocytes, a major type of glial cell, are important regulators of synapse formation and function during development. Read More

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http://dx.doi.org/10.1186/s13064-018-0104-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928581PMC
May 2018
2 Reads

Neural circuits driving larval locomotion in Drosophila.

Neural Dev 2018 04 19;13(1). Epub 2018 Apr 19.

Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR, 97403, USA.

More than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions. What is less understood is how a group of neurons from disparate anterior-posterior axial positions, lineages and developmental periods of neurogenesis coalesce to form a functional circuit. Using neurogenetic techniques developed in Drosophila it is now possible to study the neural substrates of behavior at single cell resolution. Read More

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http://dx.doi.org/10.1186/s13064-018-0103-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907184PMC
April 2018
32 Reads
1 Citation
3.453 Impact Factor

Linking neuronal lineage and wiring specificity.

Neural Dev 2018 04 13;13(1). Epub 2018 Apr 13.

Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching between pre- and post-synaptic partners. How neuronal lineage and birth timing influence wiring specificity remains an open question. Read More

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http://dx.doi.org/10.1186/s13064-018-0102-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899351PMC
April 2018
3 Reads

Monocular enucleation alters retinal waves in the surviving eye.

Neural Dev 2018 03 24;13(1). Epub 2018 Mar 24.

Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA, 95618, USA.

Background: Activity in neurons drives afferent competition that is critical for the refinement of nascent neural circuits. In ferrets, when an eye is lost in early development, surviving retinogeniculate afferents from the spared eye spread across the thalamus in a manner that is dependent on spontaneous retinal activity. However, how this spontaneous activity, also known as retinal waves, might dynamically regulate afferent terminal targeting remains unknown. Read More

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http://dx.doi.org/10.1186/s13064-018-0101-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866508PMC
March 2018
3 Reads

FGF signaling controls Shh-dependent oligodendroglial fate specification in the ventral spinal cord.

Neural Dev 2018 03 8;13(1). Epub 2018 Mar 8.

Centre de Biologie du Développement (CBD) CNRS/UPS, Centre de Biologie Intégrative (CBI), Université de Toulouse, F-31062, Toulouse, France.

Background: Most oligodendrocytes of the spinal cord originate from ventral progenitor cells of the pMN domain, characterized by expression of the transcription factor Olig2. A minority of oligodendrocytes is also recognized to emerge from dorsal progenitors during fetal development. The prevailing view is that generation of ventral oligodendrocytes depends on Sonic hedgehog (Shh) while dorsal oligodendrocytes develop under the influence of Fibroblast Growth Factors (FGFs). Read More

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http://dx.doi.org/10.1186/s13064-018-0100-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842613PMC
March 2018
6 Reads
2 Citations
3.453 Impact Factor

Transcriptional regulation of ependymal cell maturation within the postnatal brain.

Neural Dev 2018 02 16;13(1). Epub 2018 Feb 16.

The School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Background: Radial glial stem cells within the developing nervous system generate a variety of post-mitotic cells, including neurons and glial cells, as well as the specialised multi-ciliated cells that line the walls of the ventricular system, the ependymal cells. Ependymal cells separate the brain parenchyma from the cerebrospinal fluid and mediate osmotic regulation, the flow of cerebrospinal fluid, and the subsequent dispersion of signalling molecules via the co-ordinated beating of their cilia. Deficits to ependymal cell development and function have been implicated in the formation of hydrocephalus, but the transcriptional mechanisms underpinning ependymal development remain poorly characterised. Read More

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http://dx.doi.org/10.1186/s13064-018-0099-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816376PMC
February 2018
5 Reads

Correction to: Rp58 and p27 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.

Neural Dev 2018 01 11;13(1). Epub 2018 Jan 11.

The Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.

Correction: After publication of the original article [1] it was realised that there were errors in figures 2a,b,f,g, which arose as a result of preparing figures from data collected and analysed at the same time as the work reported in [2] (Supplementary Figure 1 of [2]). An updated Fig. 2 is included with this Correction. Read More

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http://dx.doi.org/10.1186/s13064-017-0098-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764026PMC
January 2018
18 Reads

Anisotropic Müller glial scaffolding supports a multiplex lattice mosaic of photoreceptors in zebrafish retina.

Neural Dev 2017 Nov 15;12(1):20. Epub 2017 Nov 15.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI, 48109-1048, USA.

Background: The multiplex, lattice mosaic of cone photoreceptors in the adult fish retina is a compelling example of a highly ordered epithelial cell pattern, with single cell width rows and columns of cones and precisely defined neighbor relationships among different cone types. Cellular mechanisms patterning this multiplex mosaic are not understood. Physical models can provide new insights into fundamental mechanisms of biological patterning. Read More

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http://dx.doi.org/10.1186/s13064-017-0096-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688757PMC
November 2017
5 Reads

Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes.

Neural Dev 2017 Nov 15;12(1):19. Epub 2017 Nov 15.

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.

Patterning of the telencephalic neuroepithelium is a tightly regulated process controlled by transcription factors and signalling molecules. The cortical primordium is flanked by two signalling centres, the hem medially, and the antihem laterally. The hem induces the formation of the hippocampus in adjacent neuroepithelium. Read More

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http://dx.doi.org/10.1186/s13064-017-0097-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688701PMC
November 2017
5 Reads

Olfactory sensory axons target specific protoglomeruli in the olfactory bulb of zebrafish.

Neural Dev 2017 Oct 11;12(1):18. Epub 2017 Oct 11.

Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

Background: The axons of Olfactory Sensory Neurons (OSNs) project to reproducible target locations within the Olfactory Bulb (OB), converting odorant experience into a spatial map of neural activity. We characterized the initial targeting of OSN axons in the zebrafish, a model system suitable for studying axonal targeting early in development. In this system the initial targets of OSN axons are a small number of distinct, individually identifiable neuropilar regions called protoglomeruli. Read More

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http://neuraldevelopment.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s13064-017-0095-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637265PMC
October 2017
7 Reads

Cell type-specific effects of p27 loss on retinal development.

Neural Dev 2017 Sep 20;12(1):17. Epub 2017 Sep 20.

Department of Anatomy, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: Cyclin-dependent kinase (CDK) inhibitors play an important role in regulating cell cycle progression, cell cycle exit and cell differentiation. p27 (p27), one of the major CDK inhibitors in the retina, has been shown to control the timing of cell cycle exit of retinal progenitors. However, the precise role of this protein in retinal development remains largely unexplored. Read More

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http://dx.doi.org/10.1186/s13064-017-0094-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607500PMC
September 2017
13 Reads

Prdm13 forms a feedback loop with Ptf1a and is required for glycinergic amacrine cell genesis in the Xenopus Retina.

Neural Dev 2017 Sep 1;12(1):16. Epub 2017 Sep 1.

Paris-Saclay Institute of Neuroscience, CNRS, Univ Paris Sud, Université Paris-Saclay, UMR 9197- Neuro-PSI, Bat. 445, 91405, ORSAY Cedex, France.

Background: Amacrine interneurons that modulate synaptic plasticity between bipolar and ganglion cells constitute the most diverse cell type in the retina. Most are inhibitory neurons using either GABA or glycine as neurotransmitters. Although several transcription factors involved in amacrine cell fate determination have been identified, mechanisms underlying amacrine cell subtype specification remain to be further understood. Read More

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http://dx.doi.org/10.1186/s13064-017-0093-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580440PMC
September 2017
10 Reads

Two Drosophila model neurons can regenerate axons from the stump or from a converted dendrite, with feedback between the two sites.

Neural Dev 2017 Aug 17;12(1):15. Epub 2017 Aug 17.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.

Background: After axon severing, neurons recover function by reinitiating axon outgrowth. New outgrowth often originates from the remaining axon stump. However, in many mammalian neurons, new axons initiate from a dendritic site when the axon is injured close to the cell body. Read More

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http://neuraldevelopment.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s13064-017-0092-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561650PMC
August 2017
5 Reads

Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2.

Neural Dev 2017 Aug 16;12(1):13. Epub 2017 Aug 16.

Divisions of Developmental Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.

Background: Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminence (dLGE) and septum. These cells migrate rostrally toward the OB, where they then radially migrate to populate different OB layers including the granule cell layer (GCL) and the outer glomerular layer (GL). Although previous studies have attempted to investigate regional contributions to OB interneuron diversity, few genetic tools have been used to address this question at embryonic time points when the earliest populations are specified. Read More

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http://neuraldevelopment.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s13064-017-0090-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559835PMC
August 2017
29 Reads

Neocortical Sox9+ radial glia generate glutamatergic neurons for all layers, but lack discernible evidence of early laminar fate restriction.

Neural Dev 2017 Aug 16;12(1):14. Epub 2017 Aug 16.

Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, 98101, USA.

Glutamatergic neurons in the cerebral cortex are derived from embryonic neural stem cells known as radial glial progenitors (RGPs). Early RGPs, present at the onset of cortical neurogenesis, are classically thought to produce columnar clones of glutamatergic neurons spanning the cortical layers. Recently, however, it has been reported that a subset of early RGPs may undergo early commitment to upper layer neuron fates, thus bypassing genesis of deep layer neurons. Read More

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http://dx.doi.org/10.1186/s13064-017-0091-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559824PMC
August 2017
4 Reads

Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression.

Neural Dev 2017 Jul 13;12(1):12. Epub 2017 Jul 13.

Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.

Background: Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does occur efficiently and involves reactivation of developmental processes. Within the neural retina of zebrafish, Müller glia are the main stem cell source and are capable of generating progenitors to replace lost neurons after injury. Read More

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http://dx.doi.org/10.1186/s13064-017-0089-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508679PMC
July 2017
5 Reads

The emergence of mesencephalic trigeminal neurons.

Neural Dev 2017 Jun 21;12(1):11. Epub 2017 Jun 21.

Centre for Developmental Neurobiology, Kings College London, London, SE1 1UL, UK.

Background: The cells of the mesencephalic trigeminal nucleus (MTN) are the proprioceptive sensory neurons that innervate the jaw closing muscles. These cells differentiate close to the two key signalling centres that influence the dorsal midbrain, the isthmus, which mediates its effects via FGF and WNT signalling and the roof plate, which is a major source of BMP signalling as well as WNT signalling.

Methods: In this study, we have set out to analyse the importance of FGF, WNT and BMP signalling for the development of the MTN. Read More

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http://dx.doi.org/10.1186/s13064-017-0088-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480199PMC
June 2017
5 Reads

Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord.

Neural Dev 2017 Jun 8;12(1):10. Epub 2017 Jun 8.

Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 Route de Narbonne, 31062, Toulouse, France.

Background: In the vertebrate spinal cord, motor neurons (MN) are generated in stereotypical numbers from a pool of dedicated progenitors (pMN) whose number depends on signals that control their specification but also their proliferation and differentiation rates. Although the initial steps of pMN specification have been extensively studied, how pMN numbers are regulated over time is less well characterized.

Results: Here, we show that ephrinB2 and ephrinB3 are differentially expressed in progenitor domains in the ventral spinal cord with several Eph receptors more broadly expressed. Read More

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http://dx.doi.org/10.1186/s13064-017-0087-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463316PMC
June 2017
12 Reads

Astroglial-mediated remodeling of the interhemispheric midline during telencephalic development is exclusive to eutherian mammals.

Neural Dev 2017 May 30;12(1). Epub 2017 May 30.

Queensland Brain Institute, The University of Queensland, St Lucia, Brisbane, 4072, Australia.

The corpus callosum forms the major interhemispheric connection in the human brain and is unique to eutherian (or placental) mammals. The developmental events associated with the evolutionary emergence of this structure, however, remain poorly understood. A key step in callosal formation is the prior remodeling of the interhemispheric fissure by embryonic astroglial cells, which then subsequently act as a permissive substrate for callosal axons, enabling them to cross the interhemispheric midline. Read More

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http://dx.doi.org/10.1186/s13064-017-0086-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450091PMC
May 2017
5 Reads

Rp58 and p27 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.

Neural Dev 2017 May 15;12(1). Epub 2017 May 15.

The Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia.

Background: During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriately to form functional neural circuits. The zinc finger transcriptional repressor Rp58 (also known as Znf238 or Zbtb18) is critical for coordinating corticogenesis, but its underlying molecular mechanism remains to be better characterised.

Findings: Here, we demonstrate that the co-expression of Rp58 and the cyclin dependent kinase inhibitor (CDKI) p27 is important for E14. Read More

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http://dx.doi.org/10.1186/s13064-017-0084-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433244PMC
May 2017
61 Reads

Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.

Neural Dev 2017 May 8;12(1). Epub 2017 May 8.

Department of Pathology, University of Illinois at Chicago, 909 S Wolcott Avenue, Chicago, IL, 60612, USA.

Background: In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly polarized radial glial cells in a neurogenic niche that controls their behavior. How adherens junctions regulate radial glial cell polarity and/or differentiation in mammalian cortical development is poorly understood. Read More

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http://dx.doi.org/10.1186/s13064-017-0085-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422985PMC
May 2017
24 Reads

Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.

Neural Dev 2017 Apr 24;12(1). Epub 2017 Apr 24.

Smurfit Institute of Genetics, School of Genetics and Microbiology, Trinity College Dublin, Dublin 2, Ireland.

Background: Sensory processing relies on projections from the thalamus to the neocortex being established during development. Information from different sensory modalities reaching the thalamus is segregated into specialized nuclei, whose neurons then send inputs to cognate cortical areas through topographically defined axonal connections. Developing thalamocortical axons (TCAs) normally approach the cortex by extending through the subpallium; here, axonal navigation is aided by distributed guidance cues and discrete cell populations, such as the corridor neurons and the internal capsule (IC) guidepost cells. Read More

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http://dx.doi.org/10.1186/s13064-017-0083-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402653PMC
April 2017
10 Reads

Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis.

Neural Dev 2017 Mar 31;12(1). Epub 2017 Mar 31.

Department of Cell Biology, University of Virginia, Charlottesville, VA, 22908, USA.

Background: How neurons change their cytoskeleton to adopt their complex polarized morphology is still not understood. Growing evidence suggests that proteins that help build microtubule structures during cell division are also involved in building and remodeling the complex cytoskeletons of neurons. Kif20b (previously called MPP1 or Mphosph1) is the most divergent member of the Kinesin-6 family of "mitotic" kinesins that also includes Kif23/MKLP1 and Kif20a/MKLP2. Read More

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http://dx.doi.org/10.1186/s13064-017-0082-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374676PMC
March 2017
10 Reads

Lacking of palladin leads to multiple cellular events changes which contribute to NTD.

Neural Dev 2017 Mar 24;12(1). Epub 2017 Mar 24.

State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Building 17, No. 197, Ruijin 2nd Rd, Shanghai, 200025, China.

Background: The actin cytoskeleton-associated protein palladin plays an important role in cell motility, morphogenesis and adhesion. In mice, Palladin deficient embryos are lethal before embryonic day (E) 15.5, and exhibit severe cranial neural tube and body wall closure defects. Read More

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http://dx.doi.org/10.1186/s13064-017-0081-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366166PMC
March 2017
10 Reads

The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development.

Neural Dev 2017 Feb 15;12(1). Epub 2017 Feb 15.

Department of Biology, Boston College, Chestnut Hill, MA, 02467, USA.

Background: Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and their plus-end tracking proteins (+TIPs) are thought to play integrative roles during this navigation. Read More

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http://dx.doi.org/10.1186/s13064-017-0080-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312526PMC
February 2017
9 Reads

Differential timing of neurogenesis underlies dorsal-ventral topographic projection of olfactory sensory neurons.

Neural Dev 2017 Feb 13;12(1). Epub 2017 Feb 13.

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, 113-0033, Japan.

Background: The mammalian primary olfactory system has a spatially-ordered projection in which olfactory sensory neurons (OSNs) located in the dorsomedial (DM) and ventrolateral (VL) region of the olfactory epithelium (OE) send their axons to the dorsal and ventral region of the olfactory bulb (OB), respectively. We previously found that OSN axonal projections occur sequentially, from the DM to the VL region of the OE. The differential timing of axonal projections is important for olfactory map formation because early-arriving OSN axons secrete guidance cues at the OB to help navigate late-arriving OSN axons. Read More

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http://dx.doi.org/10.1186/s13064-017-0079-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307877PMC
February 2017
6 Reads