378,709 results match your criteria Network: Computation in Neural Systems [Journal]


Disordered APC/C-mediated cell cycle progression and IGF1/PI3K/AKT signalling are the potential basis of Sertoli cell-only syndrome.

Andrologia 2019 Apr 17:e13288. Epub 2019 Apr 17.

Institute of Reproductive & Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.

The cause of Sertoli cell-only syndrome (SCOS), a condition in which only Sertoli cells line the seminiferous tubules in the testis, is unknown. Three microarray data sets were downloaded from public databases and were used to compare SCOS and control group. A total of 291 genes differentially expressed (Log |FC| ≥ 1 and adjusted p value < 0. Read More

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http://dx.doi.org/10.1111/and.13288DOI Listing

Self-supervised learning of the biologically-inspired obstacle avoidance of hexapod walking robot.

Bioinspir Biomim 2019 Apr 17. Epub 2019 Apr 17.

dept. of Computer Science, Ceske Vysoke Uceni Technicke Fakulta elektrotechnicka, Prague, CZECH REPUBLIC.

In this paper, we propose an integrated biologically inspired visual collision avoidance approach that is deployed on a real hexapod walking robot. The proposed approach is based on the Lobula Giant Movement Detector (LGMD) that is a neural network for looming stimuli detection that can be found in visual pathways of insects, such as locusts. Although a superior performance of the LGMD in the detection of intercepting objects has been shown in many collision avoiding scenarios, its direct integration with motion control is an unexplored topic. Read More

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http://dx.doi.org/10.1088/1748-3190/ab1a9cDOI Listing

Quantitation of vitamin K1 in serum using online SPE-LC-MS/MS and the challenges of working with vitamin K.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 7;1117:41-48. Epub 2019 Apr 7.

Department of Clinical Biochemistry and Immunology, Lillebaelt Hospital, Vejle, Denmark.

Vitamin K1 (phylloquinone) is one of the vitamin Ks. Several studies have previously investigated the role of vitamin K1 status in respect to disease, but without consistent results. Since vitamin K deficiency has been associated with different disease states it is important to develop a biochemical analysis with sufficient sensitivity and a low limit of quantitation (LOQ). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183176
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http://dx.doi.org/10.1016/j.jchromb.2019.04.010DOI Listing
April 2019
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A Comprehensive Drosophila melanogaster Transcription Factor Interactome.

Cell Rep 2019 Apr;27(3):955-970.e7

Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Systems Biology Graduate Program, Harvard University, Cambridge, MA 02138, USA; Bioinformatics and Integrative Genomics Ph.D. Program, Harvard University, Cambridge, MA 02138, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Combinatorial interactions among transcription factors (TFs) play essential roles in generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) assays on nearly all sequence-specific Drosophila TFs, we identified 1,983 protein-protein interactions (PPIs), more than doubling the number of currently known PPIs among Drosophila TFs. For quality assessment, we validated a subset of our interactions using MITOMI and bimolecular fluorescence complementation assays. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.071DOI Listing

Parallel Processing of Sound Dynamics across Mouse Auditory Cortex via Spatially Patterned Thalamic Inputs and Distinct Areal Intracortical Circuits.

Cell Rep 2019 Apr;27(3):872-885.e7

Department of Biology, University of Maryland, College Park, MD 20742, USA; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, USA. Electronic address:

Natural sounds have rich spectrotemporal dynamics. Spectral information is spatially represented in the auditory cortex (ACX) via large-scale maps. However, the representation of temporal information, e. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.069DOI Listing

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK.

Cell Rep 2019 Apr;27(3):847-859.e6

Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain. Electronic address:

Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps of mRNA biogenesis. Here, we show that osmostress has an impact on the regulation of alternative splicing (AS), which is partly mediated through the action of p38 SAPK. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.060DOI Listing

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.

Cell Rep 2019 Apr;27(3):820-834.e9

Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Equipe 11 labellisée par la Ligue contre le Cancer, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France. Electronic address:

Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor, fails to kill human cancer cells in vitro. Driven by this consideration, we attempted to identify agents that engage in synthetically lethal interactions with B87. Here, we report that dimethyl α-ketoglutarate (DMKG), a cell-permeable precursor of α-ketoglutarate that lacks toxicity on its own, kills cancer cells when combined with B87 or other inhibitors of OXPHOS. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.058DOI Listing

Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function.

Cell Rep 2019 Apr;27(3):685-689.e4

The Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, 25 Howland Street, London W1T 4JG, UK. Electronic address:

This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input. Following visual deprivation, intrinsic properties are significantly altered, although orientation selectivity across the population remains unchanged. We, therefore, suggest that cortical cells adjust their intrinsic excitability in an activity-dependent manner to compensate for changes in synaptic drive and maintain sensory network function. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.073DOI Listing

Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.

Cell Rep 2019 Apr;27(3):666-675.e5

Department of Biology, Science for Life, Utrecht University, 3584CH Utrecht, the Netherlands. Electronic address:

Dendritic inhibitory synapses are most efficient in modulating excitatory inputs localized on the same dendrite, but it is unknown whether their location is random or regulated. Here, we show that the formation of inhibitory synapses can be directed by excitatory synaptic activity on the same dendrite. We stimulated dendritic spines close to a GABAergic axon crossing by pairing two-photon glutamate uncaging with postsynaptic depolarization in CA1 pyramidal cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.078DOI Listing

Exploring the fatigue affecting electroencephalography based functional brain networks during real driving in young males.

Neuropsychologia 2019 Apr 14. Epub 2019 Apr 14.

Department of Mechanical Engineering and Automation, Northeastern University, 110819 Shenyang, Liaoning, China.

In recent years, a large proportion of traffic accidents are caused by driver fatigue. The brain has been conceived as a complex network, whose function can be assessed with EEG. Hence, in this research, fourteen subjects participated in the real driving experiments, and a comprehensive EEG-based expert system was designed for detecting driver fatigue. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.04.004DOI Listing

Oral Ketamine for Depression: A Systematic Review.

J Clin Psychiatry 2019 Apr 16;80(3). Epub 2019 Apr 16.

Mood Disorder Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: Intravenous (IV) ketamine has rapid and robust antidepressant effects; however, poor accessibility of the IV route often limits its use. Numerous alternative routes of administration are being investigated. Oral ketamine is particularly appealing for its ease of use with the potential for high accessibility. Read More

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http://dx.doi.org/10.4088/JCP.18r12475DOI Listing
April 2019
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Borders Without Enough Doctors: El Paso Physicians Volunteer Care for Asylum-Seekers.

Authors:
Sean Price

Tex Med 2019 Apr 1;115(4):30-37. Epub 2019 Apr 1.

Dr. Gutierrez is part of a small group of El Paso physicians who provide volunteer medical care at the city's 18 shelters for asylum-seekers entering the United States through the Texas border. What started in October 2018 as a local, ad hoc way to address health care needs among the steady stream of immigrants is gradually turning into a statewide - even national - network of volunteer physicians. Read More

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Infectivity enhances prediction of viral cascades in Twitter.

PLoS One 2019 17;14(4):e0214453. Epub 2019 Apr 17.

Department of Mathematics, The University of North Carolina, Chapel Hill, NC, United States of America.

Models of contagion dynamics, originally developed for infectious diseases, have proven relevant to the study of information, news, and political opinions in online social systems. Modelling diffusion processes and predicting viral information cascades are important problems in network science. Yet, many studies of information cascades neglect the variation in infectivity across different pieces of information. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214453PLOS
April 2019
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Predicting synthetic lethal interactions using conserved patterns in protein interaction networks.

PLoS Comput Biol 2019 Apr 17;15(4):e1006888. Epub 2019 Apr 17.

Bioinformatics Lab, School of Life Sciences, University of Sussex, Falmer, Brighton, United Kingdom.

In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personalised medicine strategies in cancers where specific tumour suppressors have become inactivated. Mainly due to the constraints of the experimental procedures, relatively few human synthetic lethal interactions have been identified. Read More

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http://dx.plos.org/10.1371/journal.pcbi.1006888
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http://dx.doi.org/10.1371/journal.pcbi.1006888DOI Listing
April 2019
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Preparation for and Management of "Failed" Laryngoscopy and/or Intubation.

Authors:
Richard M Cooper

Anesthesiology 2019 May;130(5):833-849

From the Department of Anesthesia, Faculty of Medicine, University of Toronto and University Health Network, Toronto General Hospital, Toronto, Ontario, Canada.

An airway manager's primary objective is to provide a path to oxygenation. This can be achieved by means of a facemask, a supraglottic airway, or a tracheal tube. If one method fails, an alternative approach may avert hypoxia. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002555DOI Listing

Cognitive fatigue and cortical-striatal network in old age.

Aging (Albany NY) 2019 Apr 17. Epub 2019 Apr 17.

School of Nursing, University of Rochester Medical Center, Rochester, NY 14623, USA.

Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort. Here we examined the relationship between the cortical-striatal network and CF (assessed by the 18-item visual analogue scale) when a group of cognitively and physically healthy older adults participated in a 30-minute cognitively fatiguing task-related fMRI experiment. We also explored whether CF would interfere with the "Posterior-Anterior Shifting in Aging" (PASA) phenomenon, an aging-associated neural reliance on frontal regions to support cognitive capacity. Read More

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http://dx.doi.org/10.18632/aging.101915DOI Listing

A Study to Explore the Parental Impact and Challenges of Self-Management in Children and Adolescents Suffering with Lymphedema.

Lymphat Res Biol 2019 Apr;17(2):245-252

2 Department of Vascular medicine, CHU Saint Eloi, University of Montpellier, Montpellier, France.

Limited research has shown the impact lymphedema has on children and families. The aim of this study was to explore the parental experience of caring for a child or adolescent with lymphedema and the daily challenges of self-management and self-efficacy. Participants were recruited during an educational camp for children with lymphedema ( = 26). Read More

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https://www.liebertpub.com/doi/10.1089/lrb.2018.0077
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http://dx.doi.org/10.1089/lrb.2018.0077DOI Listing
April 2019
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A Study to Explore the Professional Conceptualization and Challenges of Self-Management in Children and Adolescents with Lymphedema.

Lymphat Res Biol 2019 Apr;17(2):221-230

5 Lymph Clinic, Cork, Ireland.

The aim of this study was to explore the professional experience of caring for children and adolescents with lymphedema and to explore the way in which they understand and implement self-management strategies and the influence of their own self-efficacy beliefs on this process. Participants were recruited during an educational camp for children with lymphedema. Three individual semistructured focus groups were undertaken in English, French, and Italian with simultaneous translation. Read More

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http://dx.doi.org/10.1089/lrb.2018.0076DOI Listing

A Study Using Visual Art Methods to Explore the Perceptions and Barriers of Self-Management in Children and Adolescents with Lymphedema.

Lymphat Res Biol 2019 Apr;17(2):231-244

2 Department of Vascular Medicine, EA2992, CHU Saint Eloi, University of Montpellier, Montpellier, France.

The aims of this study were to explore, using visual art methodology, how children and adolescents perceive their lymphedema and conceptualize the barriers and enablers in self-management and to explore the role of an educational camp in promoting self-efficacy. Participants (speaking English, French, and Italian) were recruited during an educational camp for children with lymphedema. Children and adolescents used different methodologies to depict living and self-managing their condition. Read More

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http://dx.doi.org/10.1089/lrb.2018.0075DOI Listing

Non-muscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.

Mol Biol Cell 2019 Apr 17:mbcE18120790. Epub 2019 Apr 17.

School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.

Though many cancers are known to show upregulation of Nonmuscle myosin (NM) IIA and -IIB, the mechanism by which NMIIs aid in cancer development remains unexplored. Here we demonstrate that tumor-generating, fibroblast-like cells isolated from 3-methylcholanthrene (3MC)-induced murine tumor exhibit distinct phospho-dependent localization of NMIIA and NMIIB at the perinuclear area and tip of the filopodia and affect cell migration differentially. While NMIIA-KD affects protrusion dynamics and increases cell directionality, NMIIB-KD lowers migration speed and increases filopodial branching. Read More

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http://dx.doi.org/10.1091/mbc.E18-12-0790DOI Listing

Control of Excitatory Hierarchical Circuits by Parvalbumin-FS Basket Cells in Layer 5 of the Frontal Cortex: Insights for Cortical Oscillations.

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Division of Cerebral Circuitry, National Institute for Physiological Sciences, Japan.

The cortex contains multiple neuron types with specific connectivity and functions. Recent progress has provided a better understanding of the interactions of these neuron types as well as their output organization particularly for the frontal cortex, with implications for the circuit mechanisms underlying cortical oscillations that have cognitive functions. Layer 5 (L5) pyramidal cells (PCs) in the frontal cortex comprise two major subtypes: crossed-corticostriatal (CCS) and corticopontine (CPn) cells. Read More

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http://dx.doi.org/10.1152/jn.00778.2018DOI Listing

A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic.

JCO Clin Cancer Inform 2019 Apr(3):1-17

1 Royal College of Surgeons in Ireland, Dublin, Ireland.

Purpose: Dynamic network models predict clinical prognosis and inform therapeutic intervention by elucidating disease-driven aberrations at the systems level. However, the personalization of model predictions requires the profiling of multiple model inputs, which hampers clinical translation.

Patients And Methods: We applied APOPTO-CELL, a prognostic model of apoptosis signaling, to showcase the establishment of computational platforms that require a reduced set of inputs. Read More

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http://dx.doi.org/10.1200/CCI.18.00056DOI Listing

Hospitalization Risk During Chemotherapy for Advanced Cancer: Development and Validation of Risk Stratification Models Using Real-World Data.

JCO Clin Cancer Inform 2019 Apr(3):1-10

2 Dana-Farber Cancer Institute, Boston, MA.

Purpose: Hospitalizations are a common occurrence during chemotherapy for advanced cancer. Validated risk stratification tools could facilitate proactive approaches for reducing hospitalizations by identifying at-risk patients.

Patients And Methods: We assembled two retrospective cohorts of patients receiving chemotherapy for advanced nonhematologic cancer; cohorts were drawn from three integrated health plans of the Cancer Research Network. Read More

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https://ascopubs.org/doi/10.1200/CCI.18.00147
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http://dx.doi.org/10.1200/CCI.18.00147DOI Listing
April 2019
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The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants: An Evidence-Based Approach.

Am J Respir Crit Care Med 2019 Apr 17. Epub 2019 Apr 17.

Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Division of Neonatology, Philadelphia, Pennsylvania, United States.

Rationale: Current diagnostic criteria for bronchopulmonary dysplasia rely heavily on the level and duration of oxygen therapy, do not reflect contemporary neonatal care, nor adequately predict childhood morbidity.

Objective: To determine which of 18 pre-specified, revised definitions of bronchopulmonary dysplasia, that variably define disease presence and severity according to the level of respiratory support and supplemental oxygen administered at 36 weeks postmenstrual age, best predicts death or serious respiratory morbidity through 18-26 months corrected age.

Methods: We assessed infants born <32 weeks' gestation between 2011-2015 at 18 centers of the National Institute of Child Health and Human Development Neonatal Research Network. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201812-2348OC
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http://dx.doi.org/10.1164/rccm.201812-2348OCDOI Listing
April 2019
1 Read

Parallel multi-stream training of high-dimensional neural network potentials.

J Chem Theory Comput 2019 Apr 17. Epub 2019 Apr 17.

Over the past years high-dimensional neural network potentials (HDNNPs), fitted to accurately reproduce ab initio potential energy surfaces, have become a powerful tool in chemistry, physics and materials science. Here, we focus on the training of the neural networks that lies at the heart of the HDNNP method. We present an efficient approach for optimizing the weight parameters of the neural network via multi-stream Kalman filtering, using potential energies and forces as reference data. Read More

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http://dx.doi.org/10.1021/acs.jctc.8b01092DOI Listing

Graph-Based data integration from bioactive peptide databases of pharmaceutical interest: towards an organized collection enabling visual network analysis.

Bioinformatics 2019 Apr 17. Epub 2019 Apr 17.

Departamento de Ciencias de la Computación, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Baja California, Mexico.

Motivation: Bioactive peptides have gained great attention in the academy and pharmaceutical industry since they play an important role in human health. However, the increasing number of bioactive peptide databases is causing the problem of data redundancy and duplicated efforts. Even worse is the fact that the available data is non-standardized and often dirty with data entry errors. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz260DOI Listing

Combining Pharmacological and Nonpharmacological Interventions in Network Meta-analysis in Psychiatry.

JAMA Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England.

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0574DOI Listing

Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression: A Network Meta-analysis.

JAMA Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine, School of Public Health, Kyoto, Japan.

Importance: Cognitive behavior therapy (CBT) has been shown to be effective in the treatment of acute depression. However, whether CBT can be effectively delivered in individual, group, telephone-administered, guided self-help, and unguided self-help formats remains unclear.

Objective: To examine the most effective delivery format for CBT via a network meta-analysis. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0268DOI Listing

Can Network Meta-analysis Substitute for Direct Comparisons in Psychotherapy Trials?

JAMA Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0243DOI Listing

Reality of premature ovarian failure in Argentina.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):419-423. Epub 2019 Apr 11.

Argentinian Society of Gynecological and Reproductive Endocrinology, Buenos Aires, Argentina.

Premature Ovarian Insufficiency is defined as a decline in ovarian function that is accompanied by two biochemical determinations of Follicle Stimulating Hormone in hypergonadotropic values, in addition to low levels of circulating estrogens in women under 40 years old. Although some of its possible etiologies are recognized and diagnosed, most of the time, its cause remains unknown. It is a pathology with medical, psychological, and reproductive implications. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.419DOI Listing

Scientific collaboration in Zika: identification of the leading research groups and researchers via social network analysis.

Cad Saude Publica 2019 Apr 8;35(3):e00220217. Epub 2019 Apr 8.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

The association between Zika and microcephaly drew international attention to Brazil. The emergency situation demanded speed and collective effort by researchers worldwide, and Science was quick to investigate the disease and publish the results. Scientific knowledge was created and disseminated through collaboration in this process. Read More

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http://dx.doi.org/10.1590/0102-311X00220217DOI Listing

The network effects on conscripts' height in the central provinces of Russian empire in the middle of XIX century - at the beginning of XX century.

Anthropol Anz 2019 Apr 17. Epub 2019 Apr 17.

Moscow State University, Institute and Museum of Anthropology, Moscow, Russia.

We investigated average body height in the central provinces of the Russian empire in the middle of XIX century in view of the concept of "community effects on height". We analyzed body height correlations between neighboring districts at this time. We added information about secular changes in body height during the 19 century of this territory. Read More

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http://dx.doi.org/10.1127/anthranz/2019/0984DOI Listing

Ca-, Sr-, and Ba-Coordination polymers based on anthranilic acid via mechanochemistry.

Dalton Trans 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, D-12489 Berlin, Germany.

Ca-, Sr-, and Ba-Based coordination polymers (CPs) were prepared mechanochemically by milling metal-hydroxide samples with anthranilic acid (oABAH). {[Ca(oABA)2(H2O)3]}n (1) consists of one-dimensional polymeric chains that are further connected by a hydrogen-bonding network. {[Sr(oABA)2(H2O)2]·H2O}n (2) is a one-dimensional CP in which water molecules bridge Sr2+ ions and increase the dimensionality by building an extended network. Read More

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http://dx.doi.org/10.1039/c9dt00991dDOI Listing

Lightweight and flexible hybrid film based on delicate design of electrospun nanofibers for high-performance electromagnetic interference shielding.

Nanoscale 2019 Apr 17. Epub 2019 Apr 17.

School of Materials Science and Technology, Research Institute for Energy Equipment Materials, Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, Hebei University of Technology, Tianjin, 300401, People's Republic of China. and National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin 150080, People's Republic of China.

High-performance electromagnetic interference (EMI) shielding materials possess features of light weight, flexibility and excellent EMI shielding effectiveness. However, continuous efforts are still needed to satisfy the urgent demand for electromagnetic pollution shielding. In this study, a lightweight and flexible hybrid film with a multi-scale double-continuous conductive network (TiO2/SiO2@PPy) and sandwich structure (TiO2/SiO2@PPy@rGO) was prepared via a delicate structure design of electrospun TiO2/SiO2 nanofibers. Read More

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http://dx.doi.org/10.1039/c9nr02102gDOI Listing

Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.

Food Funct 2019 Apr 17. Epub 2019 Apr 17.

Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, China. and National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China and College of Light Industry and Food Science, Zhongkai University of Agricultural Engineering, Guangzhou 510225, China and Department of Flavor Chemistry, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart 70599, Germany and College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.

The purpose of this study was to assess the potential effects of polysaccharides from edible mushroom Grifola frondosa (GFP) on lipid metabolic disorders and gut microbiota dysbiosis, and elucidate their possible regulatory mechanisms on lipid and cholesterol metabolism in high-fat diet (HFD)-exacerbated hyperlipidemic and hypercholesterolemic rats. Results showed that oral administration of GFP markedly alleviated dyslipidaemia through decreasing the serum levels of total triglycerides, total cholesterol, and free fatty acids, and significantly suppressing hepatic lipid accumulation and steatosis. Besides, the excretion of fecal bile acids was also promoted by oral administration of GFP. Read More

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http://dx.doi.org/10.1039/c9fo00075eDOI Listing

Chlorine-assisted fabrication of hybrid supramolecular structures via electrostatic interactions.

Phys Chem Chem Phys 2019 Apr 17. Epub 2019 Apr 17.

Interdisciplinary Materials Research Center, College of Materials Science and Engineering, Tongji University, Shanghai 201804, P. R. China.

Supramolecular self-assembly is a spontaneous process relying on non-covalent intermolecular interactions. Among them, electrostatic interactions generated by organic molecules interacting with alkali metals and/or halogens play an important role in structural formation. Herein, we choose cytosine and NaCl as a model system and, from the interplay of STM imaging and DFT calculations, a hybrid network composed of both metal-organic and pure organic motifs interlinked by Cl ions via electrostatic interactions is observed on the Au(111) surface. Read More

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http://xlink.rsc.org/?DOI=C9CP01046G
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http://dx.doi.org/10.1039/c9cp01046gDOI Listing
April 2019
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Heavy-atom-free amorphous materials with facile preparation and efficient room-temperature phosphorescence emission.

Chem Commun (Camb) 2019 Apr 17. Epub 2019 Apr 17.

Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & Technology, 130 Meilong Road, Shanghai, 200237, China.

Amorphous pure organic room-temperature phosphorescent small molecules without heavy atoms, based on the intermolecular hydrogen bonding network for the immobilization of luminophores, were designed and facilely prepared via modification of heavy-atom-free luminophores onto β-cyclodextrin. Read More

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http://dx.doi.org/10.1039/c9cc01594aDOI Listing

Visible-light-mediated guest trapping in a photosensitizing porous coordination network: metal-free C-C bond-forming modification of metal-organic frameworks for aqueous-phase herbicide adsorption.

Chem Commun (Camb) 2019 Apr 17. Epub 2019 Apr 17.

Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, 310058, P. R. China.

A series of furan/thiophene-derived Cr-MIL-101s were obtained via visible-light-mediated C-C bond-forming catalysis within photosensitizing porous materials. The guest trapping process was achieved under very mild and metal-free conditions, affording newly functionalized MOFs with more π-π stacking, hydrogen bonding properties and excellent adsorption capacity in removing herbicides from aquatic environments. Read More

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http://dx.doi.org/10.1039/c9cc01371gDOI Listing

[Comprehensive treatment of a patient with Buerger's disease using genetically engineered complexes VEGF-165].

Angiol Sosud Khir 2019 ;25(1):177-180

First Moscow State Medical University named after I.M. Sechenov under the RF Ministry of Public Health, Moscow, Russia; Scientific Clinical Centre of the Open Joint-Stock Company 'Russian Railways', Moscow, Russia.

Buerger's disease, also known as thromboangiitis obliterans, is a severe invalidating systemic vascular disease. To one of the modern methods, which is distinguished by its radically new principles of action, as well as holding much promise for further study and application in treatment of patients with lower limb chronic ischaemia induced by thromboangiitis obliterans belongs the use of genetically engineered complexes based on vascular endothelial growth factor VEGF-165 ('Neovasculgen'). 'Neovasculgen' is a genetically engineered complex being a circular DNA (native plasmid on the CELO vector and Ad5), carrying the human VEGF-165 gene, encoding VEGF synthesis. Read More

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http://dx.doi.org/10.33529/angio2019124DOI Listing
January 2019
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[Predictors of early occlusion of coronary bypass grafts in patients with extremely low ejection fraction].

Angiol Sosud Khir 2019 ;25(1):153-157

Federal Centre of Cardiovascular Surgery under the RF Ministry of Public Health, Penza, Russia.

The authors carried out a retrospective study aimed at revealing predictors of early incompetence of coronary bypass grafts in patients with the ejection fraction below 30%. The study included a total of 104 patients presenting with coronary artery disease and the ejection fraction below 30%, who over the period from 2009 to 2016 underwent coronary artery bypass grafting with the use of autovenous and autoarterial conduits. 77 patients endured plasty of an aneurysm of the left ventricle (LV), 89 patients sustained plasty of the valvular apparatus. Read More

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http://dx.doi.org/10.33529/angio2019120DOI Listing
January 2019

Confirmatory factor analysis of the Insomnia Severity Index (ISI) and invariance across race: a pooled analysis of MsFLASH data.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

School of Nursing, Indiana University, Indianapolis, IN.

Objective: Women's sleep at menopause is widely reported to be problematic. The Insomnia Severity Index (ISI) is a commonly used tool for quantifying sleep problems in clinical and research settings, but psychometric properties in postmenopausal women have not been reported. Our study aim was to examine the factor structure of the ISI in a large and diverse sample of midlife women with hot flashes. Read More

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http://dx.doi.org/10.1097/GME.0000000000001343DOI Listing

Analyzing Empowerment Processes Among Cancer Patients in an Online Community: A Text Mining Approach.

JMIR Cancer 2019 Apr 17;5(1):e9887. Epub 2019 Apr 17.

Department of Health Services Research and Health Economics, National Institute of Public Health and the Environment, Bilthoven, Netherlands.

Background: Peer-to-peer online support groups and the discussion forums in these groups can help patients by providing opportunities for increasing their empowerment. Most previous research on online empowerment and online social support uses qualitative methods or questionnaires to gain insight into the dynamics of online empowerment processes.

Objective: The overall goal of this study was to analyze the presence of the empowerment processes in the online peer-to-peer communication of people affected by cancer, using text mining techniques. Read More

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http://dx.doi.org/10.2196/cancer.9887DOI Listing

Dignity Therapy Led by Nurses or Chaplains for Elderly Cancer Palliative Care Outpatients: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2019 Apr 17;8(4):e12213. Epub 2019 Apr 17.

Center for Palliative Care Research and Education, College of Nursing, University of Florida, Gainesville, FL, United States.

Background: Our goal is to improve psychosocial and spiritual care outcomes for elderly patients with cancer by optimizing an intervention focused on dignity conservation tasks such as settling relationships, sharing words of love, and preparing a legacy document. These tasks are central needs for elderly patients with cancer. Dignity therapy (DT) has clear feasibility but inconsistent efficacy. Read More

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https://www.researchprotocols.org/2019/4/e12213/
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http://dx.doi.org/10.2196/12213DOI Listing
April 2019
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Comparison of Smartphone Ownership, Social Media Use, and Willingness to Use Digital Interventions Between Generation Z and Millennials in the Treatment of Substance Use: Cross-Sectional Questionnaire Study.

J Med Internet Res 2019 Apr 17;21(4):e13050. Epub 2019 Apr 17.

Department of Psychology and Neuroscience, Baylor University, Waco, TX, United States.

Background: Problematic substance use in adolescence and emerging adulthood is a significant public health concern in the United States due to high recurrence of use rates and unmet treatment needs coupled with increased use. Consequently, there is a need for both improved service utilization and availability of recovery supports. Given the ubiquitous use of the internet and social media via smartphones, a viable option is to design digital treatments and recovery support services to include internet and social media platforms. Read More

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http://dx.doi.org/10.2196/13050DOI Listing

Adiposity, Hepatic Triglyceride, and Carotid Intima Media Thickness During Behavioral Weight Loss Treatment in Antipsychotic-Treated Youth: A Randomized Pilot Study.

J Child Adolesc Psychopharmacol 2019 Apr 17. Epub 2019 Apr 17.

1 Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.

The purpose of this pilot study was to evaluate changes in adiposity, carotid intima media thickness (CIMT), and hepatic fat content measured via magnetic resonance imaging-estimated hepatic proton density fat fraction (PDFF) in antipsychotic (AP)-treated youth versus nonpsychiatric (NP) participants during participation in a 16-week behavioral weight loss (BWL) intervention. Overweight/obese AP-treated youth ( = 26) were randomized 2:1 to weekly treatment versus recommended care (RC) over 16 weeks. NP controls ( = 21) were assigned to weekly treatment. Read More

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http://dx.doi.org/10.1089/cap.2018.0120DOI Listing

A CYP76 oxidation network of abietane diterpenes in Lamiaceae reconstituted in yeast.

J Agric Food Chem 2019 Apr 17. Epub 2019 Apr 17.

Rosemary and sage species from the Lamiaceae contain high amounts of structurally related but diverse abietane diterpenes. A number of substances from this compound family have potential pharmacological activities, and are used in the food and cosmetic industry. This has raised interest in their biosynthesis. Read More

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http://pubs.acs.org/doi/10.1021/acs.jafc.9b00714
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http://dx.doi.org/10.1021/acs.jafc.9b00714DOI Listing
April 2019
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High-flow nasal cannula oxygenation reduces postoperative hypoxemia in morbidly obese patients: a randomized controlled trial.

Minerva Anestesiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology & Critical Care, Hospital Clínico Universitario, Valencia, Spain.

Background: Postoperative pulmonary complications (PPCs) are common in high-risk surgical patients. Postoperative ventilatory management may improve their outcomes. Supplemental oxygen through a high-flow nasal cannula (HFNC) has become an alternative to classical oxygenation techniques, although the results published for postoperative patients are contradictory. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13364-0DOI Listing

Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: ‎possible cohort effect following the 2009 influenza pandemic.

Euro Surveill 2019 Apr;24(15)

University of Toronto, Toronto, Canada.

IntroductionFindings from the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) suggest children were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic.AimTo compare the age distribution of A(H1N1)pdm09 cases in 2018/19 to prior seasonal influenza epidemics in Canada.MethodsThe age distribution of unvaccinated influenza A(H1N1)pdm09 cases and test-negative controls were compared across A(H1N1)pdm09-dominant epidemics in 2018/19, 2015/16 and 2013/14 and with the general population of SPSN provinces. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1900104DOI Listing
April 2019
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Changing epidemiology of meticillin-resistant in 42 hospitals in the Dutch-German border region, 2012 to 2016: results of the search-and-follow-policy.

Euro Surveill 2019 Apr;24(15)

University of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, Netherlands.

IntroductionMeticillin-resistant (MRSA) is a major cause of healthcare-associated infections.AimWe describe MRSA colonisation/infection and bacteraemia rate trends in Dutch-German border region hospitals (NL-DE-BRH) in 2012-16.MethodsAll 42 NL-DE BRH (8 NL-BRH, 34 DE-BRH) within the cross-border network EurSafety Health-net provided surveillance data (on average ca 620,000 annual hospital admissions, of these 68. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1800244DOI Listing

Rural South African Community Perceptions of Antibiotic Access and Use: Qualitative Evidence from a Health and Demographic Surveillance System Site.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Public Health Sciences, Global Health (IHCAR), Karolinska Institutet, Stockholm, Sweden.

Knowledge and practices of rural South African populations with regard to antibiotic access and use (ABACUS) remain understudied. By using the case of four villages in the north east of the country, our aim was to investigate popular notions and social practices related to antibiotic use to inform patient-level social interventions for appropriate antibiotic use. To achieve this, we investigated where community members (village residents) were accessing and sourcing medication, and what they understood antibiotics and antibiotic resistance (ABR) to be. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0171DOI Listing