452,799 results match your criteria Netherlands Journal of Medicine[Journal]
Leuk Res 2018 Nov 27;76:39-47. Epub 2018 Nov 27.
Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands.
Flow-cytometric detection of now termed measurable residual disease (MRD) in acute myeloid leukemia (AML) has proven to have an independent prognostic impact. In a previous multicenter study we developed protocols to accurately define leukemia-associated immunophenotypes (LAIPs) at diagnosis. It has, however, not been demonstrated whether the use of the defined LAIPs in the same multicenter setting results in a high concordance between centers in MRD assessment. Read More
Arch Gerontol Geriatr 2018 Dec 6;81:111-118. Epub 2018 Dec 6.
National School of Public Health/Oswaldo Cruz Foundation, Department of Epidemiology and Quantitative Methods, Rua Leopoldo Bulhões, 1480/room 817b, Manguinhos, 21041-210 Rio de Janeiro, RJ, Brazil. Electronic address:
Purpose: To estimate the prevalence of frailty, according to Tilburg Frailty Indicator (TFI) and CHS index, to investigate the correlation between both instruments and to identify the factors associated with this condition in older users of primary health care.
Methods: This is a sectional study with 302 individuals aged 60 years or more of Rio de Janeiro/Brazil. Sociodemographic, health, functional dependence and lifestyle variables were collected. Read More
Res Dev Disabil 2018 Dec 12;85:143-153. Epub 2018 Dec 12.
Radboud University Nijmegen, Behavioural Science Institute, Nijmegen, the Netherlands; Tranzo, Tilburg University, Tilburg, the Netherlands; Praktikon, Nijmegen, the Netherlands. Electronic address:
Background: Several studies show that language problems, child behavior problems, and parental stress can co-occur in children. Still, little is known about how these domains are related in toddlers with a language disorder (LD).
Aims: This study examined relations between language problems, child behaviour problems, and parental stress in toddlers with LD and if these relations differ for children with different types of LD. Read More
Mult Scler Relat Disord 2018 Nov 30;28:44-49. Epub 2018 Nov 30.
Department of Molecular Cell biology and Immunology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC - location VUmc, Amsterdam, The Netherlands.
Background: Multiple sclerosis (MS) lacks reliable biomarkers that reflect disease activity. Recent evidence suggests that an altered sphingolipid metabolism is associated with MS pathogenesis.
Objective: To explore acid sphingomyelinase (ASM) activity and altered sphingolipid metabolism as potential biomarkers in serum of MS patients, to predict active and progressive disease, and response to disease modifying therapy (DMT). Read More
J Colloid Interface Sci 2018 Dec 5;538:605-610. Epub 2018 Dec 5.
MESA+ Institute for Nanotechnology & Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, the Netherlands. Electronic address:
Hypothesis: The stability of colloidal suspensions can be influenced by supersaturation of the supporting electrolyte with gas. It has been proposed that this effect can be attributed to the formation of nanobubbles on the surface of the colloidal particles, in turn influencing DLVO forces. While previous interpretations have focused primarily on van der Waals interactions, probing positively charged particles can provide complementary insight into electrostatic interactions. Read More
Bioresour Technol 2018 Dec 7;274:425-429. Epub 2018 Dec 7.
Section of Sanitary Engineering, Department of Water Management, Delft University of Technology, Delft 2628CN, The Netherlands; Veolia Water Technologies Techno Center Netherlands B.V., Tanthofdreef 21, 2623 EW Delft, The Netherlands.
Deep treatment is a common approach to enhance pollutant removal for biological wastewater treatment technologies (BWTTs), and life cycle assessment (LCA) holds substantial advantages to support process optimization. However, there lacks of LCA-based benchmarks that cover human-nature nexuses and stakeholder involvement, which limits the guidance and eco-design of BWTTs. This study proposed a decision-support system (DSS) by linking LCA with Water Quality Model and Conjoint Analysis. Read More
Child Abuse Negl 2018 Dec 12;88:307-316. Epub 2018 Dec 12.
Beijing Key Laboratory of Learning and Cognition, Research Center for Child Development, School of Psychology, Capital Normal University, China.
The current study examined the mediating effect of maternal negative expressiveness as well as the moderating effects of infant inhibitory control (IC) in the association between maternal childhood emotional abuse (CEA) and infant behavior problems. Drawing from 207 families from mainland China, 2-wave data were reported in this study when the infants were 6 months (T1) and 14 (T2) months. Mothers (Mean age = 32. Read More
Clin Microbiol Infect 2018 Dec 12. Epub 2018 Dec 12.
Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Objectives: This study aimed to (i) determine risk factors for enteropathogen co-infections, (ii) determine whether enteropathogen co-infections influence gastroenteritis risk, and (iii) determine whether enteropathogen co-infection occurred randomly in preschool children.
Methods: A monthly-repeated cross-sectional survey in Dutch children aged 0-48 months was conducted during October 2012-October 2014. 981 stool samples were collected along with questionnaires collecting data on gastrointestinal symptoms and potential risk factors. Read More
Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.
The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address:
Quizartinib, a second-generation FLT3 inhibitor, is in clinical development for the treatment of acute myeloid leukemia. We studied its pharmacokinetic interactions with the multidrug efflux transporters ABCB1 and ABCG2 and the multidrug metabolizing enzyme CYP3A, using in vitro transport assays and knockout and transgenic mouse models. Quizartinib was transported by human ABCB1 in vitro, and by mouse (m)Abcb1 and mAbcg2 in vivo. Read More
Osteoarthritis Cartilage 2018 Dec 12. Epub 2018 Dec 12.
Biomarker and research, Nordic Bioscience, Herlev, Denmark. Electronic address:
Objective: The aim of this narrative review is to summarize important findings from biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries and clinical and scientific need.
Design: We conducted a systematic search of electronic medical databases (Embase, Medline, Web of Science, Cochrane central) between 01-03-2017 and 31-03-2018. The search was restricted to human studies, English language and full text available publications while reviews were excluded. Read More
Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.
University Eye Clinic Maastricht, University Medical Center, Maastricht, the Netherlands.
Purpose: To determine the prevalence and factors associated with the presence of choroidal microvascular dropout (CMvD) in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes.
Design: Cross-sectional study METHODS: Thirty-six POAG eyes (36 patients) and 28 PACG eyes (28 patients) underwent optical coherence tomography angiography (OCTA). Presence of CMvD was evaluated on choroidal OCTA slabs. Read More
Head Neck 2018 Dec 15. Epub 2018 Dec 15.
Department of Oral and Maxillofacial Surgery and Special Dental Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: Chewing ability is often compromised in patients with oral cancer. The aim of this study was to identify which factors affect masticatory performance in these patients.
Methods: Patients with primary oral cancer were assessed for up to 5 years after primary treatment. Read More
Mol Oncol 2018 Dec 15. Epub 2018 Dec 15.
Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Cancer survivorship has traditionally received little prioritisation and attention. For a long time, the treatment of cancer has been the main focus of healthcare providers' efforts. It is time to increase the amount of attention given to patients' long-term well-being and their ability to return to a productive and good life. Read More
Contact Dermatitis 2018 Dec 15. Epub 2018 Dec 15.
Department of Dermatology, University of Groningen, University Medical Center Groningen, The Netherlands.
Chloramine-T (CAS no. 7080-50-4, syn. sodium p-toluenesulfonchloramide) is a crystalline powder on a chlorine basis, commonly used as a sterilizer, antiseptic, disinfectant and chemical reagent. Read More
Br J Clin Pharmacol 2018 Dec 14. Epub 2018 Dec 14.
Department of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Aims: The aims of this study were to describe the pharmacokinetics of tacrolimus immediately after kidney transplantation, and to develop a clinical tool for selecting the best starting dose for each patient.
Methods: Data on tacrolimus exposure were collected for the first three months following renal transplantation. A population pharmacokinetic analysis was conducted using nonlinear mixed-effects modeling (NONMEM). Read More
Eur Child Adolesc Psychiatry 2018 Dec 14. Epub 2018 Dec 14.
Department of Child and Adolescent Psychiatry, Amsterdam UMC, University of Amsterdam, Meibergdreef 5, 1105 AZ, Amsterdam, The Netherlands.
Adverse childhood experiences (ACEs) are associated with severe problems later in life. This study examines how eleven types of ACEs and mental health care use history are related to current psychological dysfunction among multi-problem young adults. A sample of 643 multi-problem young adult men (age 18-27) gave informed consent for us to collect retrospective regional psychiatric case register data and filled out questionnaires. Read More
Neth Heart J 2018 Dec 14. Epub 2018 Dec 14.
Department of Cardiology, Academic Medical Centre, Location Meibergdreef, University of Amsterdam, Amsterdam, The Netherlands.
Neth Heart J 2018 Dec 14. Epub 2018 Dec 14.
Department of Cardiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Neth Heart J 2018 Dec 14. Epub 2018 Dec 14.
Department of Cardiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Neuropsychol Rev 2018 Dec 14. Epub 2018 Dec 14.
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
The members of MTAC were removed from the author group and full list are shown in the Acknowledgements section. Also, members "Roee, A" and "Van Amselvoort, T" should be "Admon, R" and "Van Amelsvoort, T", respectively. The original article has been corrected. Read More
Int J Cardiovasc Imaging 2018 Dec 14. Epub 2018 Dec 14.
LKEB, LUMC, Leiden, The Netherlands.
A dedicated software package that could semi-automatically assess differences in aortic maximal cross-sectional diameters from consecutive CT scans would most likely reduce the post-processing time and effort by the physicians. The aim of this study was to present and assess the quality of a new tool for the semi-automatic quantification of thoracic aorta dilation dimensions. Twenty-nine patients with two CTA scans of the thoracic aorta for which the official clinical report indicated an increase in aortic diameters were included in the study. Read More
Psychol Res 2018 Dec 14. Epub 2018 Dec 14.
Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, 3000 DR, Rotterdam, The Netherlands.
Co-speech gestures have been proposed to strengthen sensorimotor knowledge related to objects' weight and manipulability. This pre-registered study ( https://www.osf. Read More
Intensive Care Med 2018 Dec 14. Epub 2018 Dec 14.
Department of Intensive Care Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Eur J Hum Genet 2018 Dec 14. Epub 2018 Dec 14.
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
X-inactivation is a well-established dosage compensation mechanism ensuring that X-chromosomal genes are expressed at comparable levels in males and females. Skewed X-inactivation is often explained by negative selection of one of the alleles. We demonstrate that imbalanced expression of the paternal and maternal X-chromosomes is common in the general population and that the random nature of the X-inactivation mechanism can be sufficient to explain the imbalance. Read More
Hypertens Res 2018 Dec 14. Epub 2018 Dec 14.
Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.
Excessive left ventricular (LV) mass (LVM) increase results in inefficient LV work with high energy waste and a negative prognostic effect. We aimed to investigate the presence of inappropriate LVM and to calculate the myocardial mechanoenergetic efficiency index (MEEi) in asymptomatic women with a history of early-onset (EO) or late-onset (LO) pre-eclampsia (PE). Among all women diagnosed with PE in the years 2009-2013, after applying inclusion/exclusion criteria and cost-effectiveness analysis, we randomly selected thirty women who experienced EO-PE, thirty with a previous LO-PE and thirty healthy controls to undergo echocardiography from 6 months to 4 years after delivery. Read More
Sci Rep 2018 Dec 14;8(1):17848. Epub 2018 Dec 14.
Faculty of Geo-Information Science and Earth Observation (ITC), University of Twente, Enschede, Netherlands.
Knowledge of the temporal trends and spatial patterns will have significant implications for effective preparedness in future epidemics. Our objective was to investigate the temporal trends and the nature of the spatial interaction of cholera incidences, dwelling on an outbreak in the Kumasi Metropolis, Ghana. We developed generalized nonparametric and segmented regression models to describe the epidemic curve. Read More
Sci Rep 2018 Dec 14;8(1):17845. Epub 2018 Dec 14.
Laboratory for Neutron Scattering and Imaging, Paul Scherrer Institut, Zurich, Switzerland.
Structural properties of cohesive powders are dominated by their microstructural composition. Powders with a fractal microstructure show particularly interesting properties during compaction where a microstructural transition and a fractal breakdown happen before compaction and force transport. The study of this phenomenon has been challenging due to its long-range effect and the subsequent necessity to characterize these microstructural changes on a macroscopic scale. Read More
Sci Rep 2018 Dec 14;8(1):17963. Epub 2018 Dec 14.
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More
Sci Rep 2018 Dec 14;8(1):17861. Epub 2018 Dec 14.
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Sleep and emotion are both powerful modulators of the long-term stability of episodic memories, but precisely how these factors interact remains unresolved. We assessed changes in item recognition, contextual memory, and affective tone for negative and neutral memories across a 12 h interval containing sleep or wakefulness in 71 human volunteers. Our data indicate a sleep-dependent stabilization of negative contextual memories, in a way not seen for neutral memories, item recognition, or across wakefulness. Read More
Sci Rep 2018 Dec 14;8(1):17853. Epub 2018 Dec 14.
University of Leiden, Leiden Institute of Chemistry, Einsteinweg 55, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
The solid-state photo-CIDNP (photochemically induced dynamic nuclear polarization) effect allows for increase of signal and sensitivity in magic-angle spinning (MAS) NMR experiments. The effect occurs in photosynthetic reaction centers (RC) proteins upon illumination and induction of cyclic electron transfer. Here we show that the strength of the effect allows for observation of the cofactors forming the spin-correlated radical pair (SCRP) in isolated proteins, in natural photosynthetic membranes as well as in entire plants. Read More
Nat Commun 2018 Dec 14;9(1):5324. Epub 2018 Dec 14.
Department of Marine Biology, The Leon H. Charney School of Marine Sciences, University of Haifa, Mt. Carmel, 3498838, Haifa, Israel.
Aging (Albany NY) 2018 Dec 13. Epub 2018 Dec 13.
Department of Cardiology, University Hospital of Antwerp, Antwerp, Belgium.
J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.
Dept of Internal Medicine & Radboud Center for Infectious Diseases, Radboud university medical ctr.
Current guidelines recommend intravenous antibiotic therapy for at least 4 weeks in patients with high-risk Staphylococcus aureus bacteremia (SAB), because of the risk for metastatic infection. We evaluated the safety of shorter duration of treatment in patients with high-risk SAB without signs of metastatic infection at presentation, using standard F-FDG PET/CT and echocardiography. Retrospective analyses were performed of patients with SAB admitted between 2013 and 2017 in two medical centers. Read More
Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.
Immunology Development, AbbVie, North Chicago, Illinois, USA.
Objective: To assess the efficacy, safety, pharmacokinetics and pharmacodynamics of the anti-interleukin (IL)-1α/β dual variable domain immunoglobulin lutikizumab (ABT-981) in erosive hand osteoarthritis (HOA).
Methods: Patients with ≥1 erosive and ≥3 tender and/or swollen hand joints were randomised to placebo or lutikizumab 200 mg subcutaneously every 2 weeks for 24 weeks. The primary endpoint was change in Australian/Canadian Osteoarthritis Hand Index (AUSCAN) pain subdomain score from baseline to 16 weeks. Read More
J Immunol 2018 Dec 14. Epub 2018 Dec 14.
The Bateson Centre, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom;
Drug-resistant mycobacteria are a rising problem worldwide. There is an urgent need to understand the immune response to tuberculosis to identify host targets that, if targeted therapeutically, could be used to tackle these currently untreatable infections. In this study we use an Il-1β fluorescent transgenic line to show that there is an early innate immune proinflammatory response to well-established zebrafish models of inflammation and infection. Read More
Blood Adv 2018 Dec;2(24):3566-3571
Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
Early data on venetoclax-containing regimens for the treatment of chronic lymphocytic leukemia (CLL) show promising results with deep remissions, but are hampered by potential risk for tumor lysis syndrome (TLS). Whether optimal duration of venetoclax treatment can be guided by minimal residual disease (MRD) is currently unknown. To study whether TLS risk can be mitigated in an unfit population by introducing preinduction, and whether MRD-guided duration of venetoclax treatment is a feasible and efficacious approach, we performed the Dutch-Belgian Cooperative Trial Group for Hemato-oncology (HOVON) 139/GIVE trial. Read More
Diabetes Care 2018 Dec 14. Epub 2018 Dec 14.
Department of Medical Psychology, VU University Medical Center, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
Objective: Successful self-management of type 1 diabetes requires cognitive skills such as executive functioning (EF). In the transition to adolescence, youth take over responsibility for diabetes management. We set out to test: ) the association between EF and glycemic control over time and ) whether this association was moderated: ) by youth, shared, or parent responsibility for diabetes management and ) youth's age. Read More
Sci Immunol 2018 Dec;3(30)
Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Tissue-resident memory T cells (T) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes T to tissue damage. This history of danger-signal exposure is an important aspect of T-mediated immunity that has been overlooked so far. Read More
Lancet Respir Med 2018 Dec 11. Epub 2018 Dec 11.
Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. Electronic address:
Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma.
Methods: In this genome-wide association study, we used a two-stage case-control design. Read More
Immunity 2018 Nov 29. Epub 2018 Nov 29.
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address:
Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge. However, conditions for nAb-mediated protection after vaccination have not been established. Here, we selected groups of 6 rhesus macaques with either high or low serum nAb titers from a total of 78 animals immunized with recombinant native-like (SOSIP) Env trimers. Read More
Immunity 2018 Dec 5. Epub 2018 Dec 5.
Duke Human Vaccine Institute, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA; Department of Immunology, Duke University, Durham, NC, USA. Electronic address:
Elicitation of VRC01-class broadly neutralizing antibodies (bnAbs) is an appealing approach for a preventative HIV-1 vaccine. Despite extensive investigations, strategies to induce VRC01-class bnAbs and overcome the barrier posed by the envelope N276 glycan have not been successful. Here, we inferred a high-probability unmutated common ancestor (UCA) of the VRC01 lineage and reconstructed the stages of lineage maturation. Read More
Mol Ther 2018 Dec 11. Epub 2018 Dec 11.
Hubrecht Institute, KNAW and University Medical Center Utrecht, the Netherlands; Department of Cardiology, University Medical Center Utrecht, the Netherlands. Electronic address:
Syst Appl Microbiol 2018 Dec 11. Epub 2018 Dec 11.
Winogradsky Institute of Microbiology, Research Centre of Biotechnology, Russian Academy of Sciences, Moscow, Russia; Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Radiother Oncol 2018 Dec 11. Epub 2018 Dec 11.
Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
Background And Purpose: In a separate article (PART 1), a rationale and explanation of the physiology-and-anatomy-based concept of Functional Swallowing Units (FSUs) was presented. FSUs are swallowing muscles not included in the set of commonly defined swallowing organs at risk (SWOARs). They are involved in three crucial swallowing components: hyolaryngeal elevation (HLE), tongue base retraction (TBR) and tongue motion. Read More
Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:97-103. Epub 2018 Nov 22.
Department of Gastroenterology & Hepatology, Erasmus MC University Medical Centre, Rotterdam, the Netherlands. Electronic address:
Palliation of dysphagia is the cornerstone of palliative treatment in patients with incurable oesophageal cancer. Available palliative options for dysphagia are oesophageal stent placement and radiotherapy. In general, oesophageal stent placement is the preferred therapeutic option in patients with a relatively poor prognosis because of its rapid relief of dysphagia. Read More
Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:91-96. Epub 2018 Nov 24.
Department of Surgery, Erasmus MC - University Medical Center Rotterdam, PO BOX 2040, 3000, CA, Rotterdam, the Netherlands. Electronic address:
The incidence of esophageal and junctional cancer has been increasing in western industrialized nations in the past 30 years. At the time of diagnosis, approximately 50% of patients with esophageal and junctional cancers have distant metastases and are considered incurable. In the recent ESMO guidelines and the German S3 guidelines, surgical therapy for metastatic disease is not recommended. Read More
Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:81-83. Epub 2018 Nov 29.
Department of Surgery, G04.228, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.
Worldwide, the standard treatment for locally advanced esophageal cancer with curative intent is perioperative chemotherapy or preoperative chemoradiotherapy followed by open transthoracic esophagectomy (OTE) with gastric conduit reconstruction. Minimally invasive esophagectomy (MIE) was developed to improve the postoperative outcome by reducing the surgical trauma, with comparable short-term oncologic results. However, MIE is a highly complex procedure associated with a long learning curve. Read More
Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:53-59. Epub 2018 Nov 21.
Amsterdam University Medical Centers, Cancer Center Amsterdam, Location Academic Medical Center, Department of Radiation Oncology, Meibergdreef 9; B0-107, 1105 AZ, Amsterdam, Netherlands. Electronic address:
Definitive chemoradiation (dCRT) is a curative treatment option for patients with oesophageal cancer. It is effective in both adenocarcinoma and squamous cell carcinoma. However, locoregional control is less after dCRT compared to preoperative CRT (pCRT) followed by surgery. Read More
Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:45-52. Epub 2018 Nov 22.
Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Centers (UMC) Location AMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:
During the past decades, several treatment strategies such as neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy and perioperative chemotherapy have been shown to improve the prognosis of resectable esophageal cancer. Patients with squamous cell tumors respond better to neoadjuvant chemoradiotherapy compared to adenocarcinoma. Therefore, in squamous tumors neoadjuvant chemoradiotherapy is the preferred strategy. Read More
Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:37-44. Epub 2018 Nov 22.
Department of Surgery, Erasmus MC - University Medical Centre Rotterdam, Dr. Molenwaterplein 40, 3000 CA, Rotterdam, the Netherlands.
At present, treatment of potentially curable oesophageal cancer includes neoadjuvant chemoradiotherapy followed by oesophagectomy. Alternatively, neoadjuvant chemotherapy is used. To date, strong evidence on the superiority of one modality over the other has not been provided. Read More